Rapid growth of retinoblastoma in a premature twinDavid H Abramson
Arch Ophthalmol 120:1232-3. 2002
Systemic carboplatin for retinoblastoma: change in tumour size over timeD H Abramson
70 East 66th Street, New York, NY 10021, USA
Br J Ophthalmol 89:1616-9. 2005
..Quantitative data regarding retinal tumour response following treatment with primary systemic carboplatin are reported...
- Screening for retinoblastoma: presenting signs as prognosticators of patient and ocular survival
David H Abramson
Robert M Ellsworth Ophthalmic Oncology Center, Department of Ophthalmology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, USA
Pediatrics 112:1248-55. 2003
..To correlate 3 common presenting signs of retinoblastoma with patient and ocular survival and to assess the efficacy of current pediatric screening practices for retinoblastoma...
- Update on retinoblastoma
David H Abramson
Ophthalmic Oncology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Retina 24:828-48. 2004
- Optic nerve tissue shrinkage during pathologic processing after enucleation for retinoblastoma
David H Abramson
Department of Ophthalmology, New York Presyterian Hospital Weill Medical College of Cornell University, New York, NY, USA
Arch Ophthalmol 121:73-5. 2003
..To quantify and analyze the differences between the length of the optic nerve as measured by the ophthalmologist in the operating room after enucleation and the length as measured by the pathologist after fixation...
- Successful treatment of metastatic retinoblastoma
I J Dunkel
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer 89:2117-21. 2000
..In the current study, the authors evaluated the use of combined intensive conventional chemotherapy, high dose chemotherapy with autologous stem cell rescue (ASCR), and radiation therapy...
Orbital recurrence of retinoblastoma following enucleationJ W Kim
Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
Br J Ophthalmol 93:463-7. 2009
..To determine the incidence, clinical presentation and histopathological profile of patients developing orbital recurrence following enucleation for retinoblastoma...
- Third (fourth and fifth) nonocular tumors in survivors of retinoblastoma
D H Abramson
Department of Ophthalmology, New York-Presbyterian Hospital, New York Weill Cornell Medical Center, New York, New York, USA
Ophthalmology 108:1868-76. 2001
..The locations and expected ages at which additional tumors develop are consistent with the patterns we have seen in second tumors...
- Engraftment and growth of patient-derived retinoblastoma tumour in severe combined immunodeficiency mice
Y Yan
Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Eur J Cancer 36:221-8. 2000
..c. inoculation and suggest the possibility of using the SCID mouse model to study the intrinsic biological behaviour of human retinoblastoma and to develop novel therapeutic strategies in the treatment of this disease...
- Intra-arterial chemotherapy as a treatment for intraocular retinoblastoma: alternatives to direct ophthalmic artery catheterization
M A Klufas
Department of Ophthalmology, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA
AJNR Am J Neuroradiol 33:1608-14. 2012
..The purpose of this work was to report our initial results with intra-arterial chemotherapy for intraocular retinoblastoma when delivery of the drug was not via direct catheterization of the OA...
- Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: an extended follow-up
Ruth A Kleinerman
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852 7362, USA
J Clin Oncol 23:2272-9. 2005
..We have extended the follow-up of a large cohort of Rb patients for 7 more years to provide new information on the risk of additional cancers after radiotherapy in long-term survivors...
- Topotecan vitreous levels after periocular or intravenous delivery in rabbits: an alternative for retinoblastoma chemotherapy
Angel M Carcaboso
Departments of Pharmacology, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
Invest Ophthalmol Vis Sci 48:3761-7. 2007
..To determine the extent and the mechanism by which topotecan, a candidate agent for the treatment of retinoblastoma, gains access to the vitreous when administered by periocular injection or intravenous infusion...
- An aggressive bone marrow evaluation including immunocytology with GD2 for advanced retinoblastoma
Guillermo L Chantada
Department of Hemato Oncology, Hospital JP Garrahan, Buenos Aires, Argentina
J Pediatr Hematol Oncol 28:369-73. 2006
..GD2 was intensively expressed and it may also be used to monitor disease response and the presence of minimal residual disease...
- Tobacco use in adult long-term survivors of retinoblastoma
Meredith C Foster
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7044, 6120 Executive Boulevard, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 15:1464-8. 2006
..Smoking did not account for the increased risk of lung cancer among hereditary Rb patients, and this may point to an enhanced sensitivity to the carcinogenic effects of tobacco. Adult survivors of Rb should be encouraged to stop smoking...
- Growing melanocytic tumor is not always cancer
David H Abramson
Arch Ophthalmol 123:1457-8. 2005
- Risk of soft tissue sarcomas by individual subtype in survivors of hereditary retinoblastoma
Ruth A Kleinerman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS 7044, 6120 Executive Blvd, Rockville, MD 20852, USA
J Natl Cancer Inst 99:24-31. 2007
..Survivors of hereditary retinoblastoma have an increased risk for second malignancies, especially soft tissue sarcomas. However, the risks of individual histologic subtypes of soft tissue sarcomas have not been evaluated...
- The adverse events of chemotherapy for retinoblastoma: what are they? Do we know?
Allison E Rizzuti
Arch Ophthalmol 126:862-5. 2008
- A phase II trial of carboplatin for intraocular retinoblastoma
Ira J Dunkel
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Pediatr Blood Cancer 49:643-8. 2007
....
- Risk factors for extraocular relapse following enucleation after failure of chemoreduction in retinoblastoma
Guillermo L Chantada
Department of Hemato Oncology, Hospital JP Garrahan, Buenos Aires, Argentina, and Department of Pathology, University of Sao Paulo, Brazil
Pediatr Blood Cancer 49:256-60. 2007
..To assess the outcome and determine risk factors for extraocular relapse in patients with retinoblastoma who had been enucleated after failure of chemoreduction...
- Secondary acute myelogenous leukemia in patients with retinoblastoma: is chemotherapy a factor?
Dan S Gombos
Section of Ophthalmology, Department of Head and Neck Surgery, MD Anderson Cancer Center, Houston, Texas 77030, USA
Ophthalmology 114:1378-83. 2007
..To describe a series of patients with secondary acute myelogenous leukemia (sAML) and retinoblastoma (RB)...
- Current management strategies for intraocular retinoblastoma
Jonathan W Kim
Department of Ophthalmic Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Drugs 67:2173-85. 2007
..Therefore, modern centres treating retinoblastoma continue to manage patients with a variety of modalities, individualising the therapy according to the patient's presentation and clinical course...
- A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma initial results
David H Abramson
Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Ophthalmology 115:1398-404, 1404.e1. 2008
....
- Cancer screening practices of adult survivors of retinoblastoma at risk of second cancers
Victoria Sheen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
Cancer 113:434-41. 2008
..The aim of the current study was to investigate the pattern of cancer screening behavior in adult retinoblastoma survivors, who are at high risk of developing second cancers...
- Impairments in antifolate transport are common in retinoblastoma tumor samples
Richard G Gorlick
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Pediatr Blood Cancer 50:573-6. 2008
..Identification of effective chemotherapy agents for retinoblastoma that are not associated with an elevated risk of secondary malignancy would be beneficial...
- Periocular chemotherapy for retinoblastoma: success with problems?
David H Abramson
Arch Ophthalmol 123:128-9; author reply 129. 2005
- Brain necrosis after enucleation, external beam cobalt radiotherapy, and systemic chemotherapy for retinoblastoma
Gilbert D A Padula
Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
Arch Ophthalmol 120:98-9. 2002
- Delayed diagnosis of retinoblastoma: analysis of degree, cause, and potential consequences
Linda J Butros
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Pediatrics 109:E45. 2002
....
- (Neonatal) retinoblastoma in the first month of life
David H Abramson
Robert M Ellsworth Ophthalmic Oncology Center, New York Presbyterian Hospital Weill Cornell Medical College, NY, USA
Arch Ophthalmol 120:738-42. 2002
..To identify patients with retinoblastoma whose conditions were diagnosed at the age of 1 month or younger and to describe their clinical features (including ocular and patient survival) and the development of second nonocular tumors...
- Osteogenic sarcoma in a survivor of metastatic germline retinoblastoma: the possible influence of human growth hormone
David H Abramson
New York Presbyterian Hospital, Weill Medical College, Cornell University, New York, USA
J Pediatr Ophthalmol Strabismus 39:347-8. 2002
- Impact on survivors of retinoblastoma when informed of study results on risk of second cancers
Charlene J Schulz
Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Med Pediatr Oncol 41:36-43. 2003
..Additional studies are needed to identify individuals who experience greater levels of distress following feedback in an attempt to provide improved methods of feedback and support...
- Bilateral retinoblastoma, microphthalmia, and colobomas in the 13q deletion syndrome
Lisa S Schocket
Scheie Eye Institute, University of Pennsylvania, Philadelphia 19104, USA
Arch Ophthalmol 121:916-7. 2003
- New retinoblastoma tumor formation in children initially treated with systemic carboplatin
Thomas C Lee
Department of Ophthalmology, New York-Presbyterian Hospital-Weill Medical College of Cornell University, 70 East 66th Street, New York, NY 10021, USA
Ophthalmology 110:1989-94; discussion 1994-5. 2003
..0182). CONCLUSIONS: New intraocular tumors continue to develop after systemic carboplatin; most new tumors appeared within 4 months of treatment...
- Metastatic ocular melanoma
David H Abramson
Arch Ophthalmol 122:658-9. 2004
- Transpupillary thermotherapy as initial treatment for small intraocular retinoblastoma: technique and predictors of success
David H Abramson
Department of Ophthalmology, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York, USA
Ophthalmology 111:984-91. 2004
..CONCLUSIONS: Retinoblastoma tumors <1.5 DD in base diameter can be successfully treated with TTT alone. Treatment can be implemented only when recurrences occur and can be used at low power settings for a short duration...
- Chorioretinal scar growth after 810-nanometer laser treatment for retinoblastoma
Thomas C Lee
Ophthalmic Oncology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
Ophthalmology 111:992-6. 2004
..CONCLUSIONS: Scars from TTT for retinoblastoma may increase in size after treatment. This expansion must be considered when applying TTT to tumors near vital macular structures, such as the fovea and optic nerve...
- Visual fields in retinoblastoma survivors
David H Abramson
Ophthalmology Oncology Service, Departments of Surgery, Radiation Oncology, and Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
Arch Ophthalmol 122:1324-30. 2004
..To describe the visual field defects in retinoblastoma survivors and relate those defects to characteristics such as tumor size, tumor location, and treatment modality...
- Variates of survival in metastatic uveal melanoma
Petra Rietschel
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
J Clin Oncol 23:8076-80. 2005
..Data on variates of survival and site of first metastasis may guide strategies for screening patients, although our data failed to show a survival advantage in discovering asymptomatic metastatic disease...
- Outcome following initial external beam radiotherapy in patients with Reese-Ellsworth group Vb retinoblastoma
David H Abramson
Department of Ophthalmology, New York Presbyterian Hospital-Weill Medical College of Cornell University, 70 E. 66th Street, New York, NY 10021, USA
Arch Ophthalmol 122:1316-23. 2004
..Outcome data provided herein are clinically relevant when choosing treatment options for advanced intraocular retinoblastoma...
- Tadalafil-induced subretinal and choroidal hemorrhage in a patient with an unsuspected uveal (choroidal and ciliary body) melanoma
David H Abramson
Arch Ophthalmol 124:1058-60. 2006
- Fruit and vegetable intake during pregnancy and risk for development of sporadic retinoblastoma
Manuela A Orjuela
Department of Pediatrics, Mailman School of Public Health at Columbia University, Room B106, 60 Haven Avenue, New York, New York 10032, USA
Cancer Epidemiol Biomarkers Prev 14:1433-40. 2005
..Fruits and vegetables are important sources of carotenoids and folate. We examined whether decreased gestational maternal intake of fruits and vegetables may contribute to development of sporadic retinoblastoma...
- High-dose supplements for age-related macular degeneration: did you leave out centrum?
David H Abramson
Arch Ophthalmol 120:1602. 2002
- Retinoblastoma in the 20th century: past success and future challenges the Weisenfeld lecture
David H Abramson
Ophthalmic Oncology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10023, USA
Invest Ophthalmol Vis Sci 46:2683-91. 2005
- More aggressive bone marrow screening in retinoblastoma patients is not indicated: the memorial Sloan-Kettering cancer center experience
Stergios Zacharoulis
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Pediatr Blood Cancer 46:56-61. 2006
....
- Clinical implications of promoter hypermethylation in RASSF1A and MGMT in retinoblastoma
Kwong Wai Choy
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, Hong Kong, China
Neoplasia 7:200-6. 2005
..Epigenetic mechanism plays an important role in the progression of retinoblastoma...
- Treatment of choroidal melanoma using photodynamic therapy
Irene A Barbazetto
E S Harkness Eye Institute, New York Presbyterian Hospital, Columbia University, New York, New York 10032, USA
Am J Ophthalmol 135:898-9. 2003
..To InternetAdvance publication at ajo.com Feb 26, 2002. investigate the effect of photodynamic therapy using verteporfin on choroidal melanoma...
- Lack of activity of oral etoposide for relapsed intraocular retinoblastoma
Ira J Dunkel
Department of Pediatrics, Memorial-Sloan Kettering Cancer Center, New York, NY, USA
Ophthalmic Genet 25:25-9. 2004
..CONCLUSIONS: Oral etoposide was not an effective agent in this population. The role of etoposide in the treatment of higher risk intraocular retinoblastoma deserves further study...
- Preimplantation genetic diagnosis for retinoblastoma: the first reported liveborn
Kangpu Xu
Institute for Reproductive Medicine, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
Am J Ophthalmol 137:18-23. 2004
....
Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cellsDavid Cobrinik
Margaret M, Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
Mol Cancer 5:72. 2006
..Retinoblastoma is caused by loss of the Rb protein in early retinal cells. Although numerous Rb functions have been identified, Rb effects that specifically relate to the suppression of retinoblastoma have not been defined...
- Small molecule inhibition of HDM2 leads to p53-mediated cell death in retinoblastoma cells
Jasmine R Elison
Department of Ophthalmology, Weill Medical College of Cornell University, New York Presbyterian Hospital, 520 E. 70th Street, New York, NY 10021, USA
Arch Ophthalmol 124:1269-75. 2006
..Because the mutagenic effects of radiation and chemotherapy may increase risks of secondary tumor formation, targeted p53 activation may be a safer alternative treatment for retinoblastoma in the future...
- Microsatellite instability and MLH1 promoter methylation in human retinoblastoma
Kwong Wai Choy
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon
Invest Ophthalmol Vis Sci 45:3404-9. 2004
..The results showed that somatic genetic changes involving MSI occur in a subset of retinoblastoma and implicated the presence of a defective DNA mismatch repair pathway resulting in MSI in retinoblastoma...
