Brett S Abrahams

Summary

Publications

  1. pmc Advances in autism genetics: on the threshold of a new neurobiology
    Brett S Abrahams
    Neurology Department, and Semel Institute for Neuroscience and Behaviour, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1769 USA
    Nat Rev Genet 9:341-55. 2008
  2. pmc Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
    Olga Penagarikano
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 147:235-46. 2011
  3. pmc Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2
    Ashley A Scott-Van Zeeland
    Center for Cognitive Neuroscience, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Sci Transl Med 2:56ra80. 2010
  4. pmc Connecting genes to brain in the autism spectrum disorders
    Brett S Abrahams
    Neurogenetics Program, Neurology Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1769, USA
    Arch Neurol 67:395-9. 2010
  5. ncbi request reprint Unexpected embryonic stem (ES) cell mutations represent a concern in gene targeting: lessons from "fierce" mice
    Ravinesh A Kumar
    Doctorate Program in Medical Genetics, University of British Columbia, Vancouver, British Columbia, V5Z 4H4 Canada
    Genesis 38:51-7. 2004
  6. ncbi request reprint Pathological aggression in "fierce" mice corrected by human nuclear receptor 2E1
    Brett S Abrahams
    Graduate Program in Neuroscience, British Columbia Research Institute for Children s and Women s Health, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada
    J Neurosci 25:6263-70. 2005
  7. pmc Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene
    Maricela Alarcon
    UCLA Center for Autism Research and Treatment, Semel Institute of Neuroscience, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Hum Genet 82:150-9. 2008
  8. pmc Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders
    Betul Bakkaloglu
    Program on Neurogenetics, Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Hum Genet 82:165-73. 2008

Collaborators

  • Jonathan Sebat
  • Daniel H Geschwind
  • Olga Penagarikano
  • Mirella Dapretto
  • Anatol Bragin
  • M W State
  • Katarzyna Chawarska
  • A Klin
  • Rita M Cantor
  • Ashley A Scott-Van Zeeland
  • Maricela Alarcon
  • Betul Bakkaloglu
  • Ravinesh A Kumar
  • Dara Ghahremani
  • Susan Y Bookheimer
  • Ana I Alvarez-Retuerto
  • Jeffrey D Rudie
  • Russell A Poldrack
  • Lisa I Sonnenblick
  • Jeanette A Mumford
  • David H Ledbetter
  • Abha R Gupta
  • Richard P Lifton
  • Christa L Martin
  • Gamze Tanriover
  • Jackie A Duvall
  • Stanley F Nelson
  • Brian J O'Roak
  • Elissa M Robbins
  • Jennifer L Stone
  • Julia V Perederiy
  • Jesse F Abelson
  • Michael Wigler
  • Jamee M Bomar
  • A Gulhan Ercan-Sencicek
  • Angeliki Louvi
  • Jacqueline A Duvall
  • Althea A Stillman
  • Murat Gunel
  • Thomas Biederer
  • Thomas M Morgan
  • Ambrose H W Wong
  • Elizabeth M Simpson
  • Ka Ling Chan
  • Evica Rajcan-Separovic
  • Ken Q Little

Detail Information

Publications8

  1. pmc Advances in autism genetics: on the threshold of a new neurobiology
    Brett S Abrahams
    Neurology Department, and Semel Institute for Neuroscience and Behaviour, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1769 USA
    Nat Rev Genet 9:341-55. 2008
    ..Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme...
  2. pmc Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
    Olga Penagarikano
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 147:235-46. 2011
    ..These data demonstrate a functional role for CNTNAP2 in brain development and provide a new tool for mechanistic and therapeutic research in ASD...
  3. pmc Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2
    Ashley A Scott-Van Zeeland
    Center for Cognitive Neuroscience, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Sci Transl Med 2:56ra80. 2010
    ..The convergence between genetic findings and cognitive-behavioral models of autism provides evidence that genetic variation at CNTNAP2 predisposes to diseases such as autism in part through modulation of frontal lobe connectivity...
  4. pmc Connecting genes to brain in the autism spectrum disorders
    Brett S Abrahams
    Neurogenetics Program, Neurology Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1769, USA
    Arch Neurol 67:395-9. 2010
    ..Understanding genetic data within an anatomical context will be critical to explain how individual risk factors operate to shape phenotypic presentation in patients...
  5. ncbi request reprint Unexpected embryonic stem (ES) cell mutations represent a concern in gene targeting: lessons from "fierce" mice
    Ravinesh A Kumar
    Doctorate Program in Medical Genetics, University of British Columbia, Vancouver, British Columbia, V5Z 4H4 Canada
    Genesis 38:51-7. 2004
    ....
  6. ncbi request reprint Pathological aggression in "fierce" mice corrected by human nuclear receptor 2E1
    Brett S Abrahams
    Graduate Program in Neuroscience, British Columbia Research Institute for Children s and Women s Health, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada
    J Neurosci 25:6263-70. 2005
    ..Use of this rescue paradigm with other genes will permit the direct evaluation of human genes hypothesized to play a causal role in psychiatric disease but for which evidence is lacking or equivocal...
  7. pmc Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene
    Maricela Alarcon
    UCLA Center for Autism Research and Treatment, Semel Institute of Neuroscience, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Hum Genet 82:150-9. 2008
    ..Together, these results provide convergent evidence for involvement of CNTNAP2, a Neurexin family member, in autism, and demonstrate a connection between genetic risk for autism and specific brain structures...
  8. pmc Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders
    Betul Bakkaloglu
    Program on Neurogenetics, Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Hum Genet 82:165-73. 2008
    ....