Mohamed Abdel-Aziz

Summary

Publications

  1. doi request reprint Synthesis, cytotoxic properties and tubulin polymerization inhibitory activity of novel 2-pyrazoline derivatives
    Mohamed Abdel-Aziz
    Faculty of Pharmacy, Medicinal Chemistry Department, Minia University, Minia, Egypt
    Arch Pharm (Weinheim) 345:535-48. 2012
  2. doi request reprint Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Eur J Med Chem 44:3480-7. 2009
  3. ncbi request reprint N-malonyl-1,2-dihydroisoquinoline as a novel carrier for specific delivery of drugs to the brain
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Arch Pharm (Weinheim) 343:54-60. 2010
  4. ncbi request reprint Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Eur J Med Chem 45:3384-8. 2010
  5. doi request reprint 1-Malonyl-1,4-dihydropyridine as a novel carrier for specific delivery of drugs to the brain
    Heba A Hassan
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Bioorg Med Chem 17:1681-92. 2009
  6. doi request reprint Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide
    el Shimaa M N Abdel-Hafez
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Bioorg Med Chem 17:3829-37. 2009
  7. doi request reprint Design, synthesis and anticancer activity of nitric oxide donating/chalcone hybrids
    Mai A E Mourad
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Eur J Med Chem 54:907-13. 2012
  8. doi request reprint New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities
    Mohamed Abdel-Aziz
    Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Bioorg Med Chem 21:3839-49. 2013
  9. ncbi request reprint Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Eur J Med Chem 69:427-38. 2013
  10. doi request reprint Synthesis, anti-inflammatory activity and ulcerogenic liability of novel nitric oxide donating/chalcone hybrids
    Gamal El Din A A Abuo-Rahma
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Bioorg Med Chem 20:195-206. 2012

Collaborators

  • Alaa A Hassan
  • Mohamed A Morsy
  • Gamal El Din A A Abuo-Rahma
  • Hassan H Farag
  • Mai A E Mourad
  • Mai E Shoman
  • el Shimaa M N Abdel-Hafez
  • Heba A Hassan
  • Tamer S Kaoud
  • Nahla A Farag
  • Eman A M Beshr
  • Taha F S Ali
  • Omar M Aly
  • Mohamed F Radwan

Detail Information

Publications15

  1. doi request reprint Synthesis, cytotoxic properties and tubulin polymerization inhibitory activity of novel 2-pyrazoline derivatives
    Mohamed Abdel-Aziz
    Faculty of Pharmacy, Medicinal Chemistry Department, Minia University, Minia, Egypt
    Arch Pharm (Weinheim) 345:535-48. 2012
    ..Molecular modeling studies involving compound 6e with the colchicine binding site of α,β-tubulin revealed hydrogen-bonding and hydrophobic interactions with several amino acids in the colchicine binding site of β-tubulin...
  2. doi request reprint Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Eur J Med Chem 44:3480-7. 2009
    ..p. injection of PTZ at a dose level of 20 mg kg(-1). The results of anticonvulsant activity are nearly close to phenobarbital sodium at a dose level of 30 mg kg(-1) and more potent than phenytoin sodium at a dose level of 30 mg kg(-1)...
  3. ncbi request reprint N-malonyl-1,2-dihydroisoquinoline as a novel carrier for specific delivery of drugs to the brain
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Arch Pharm (Weinheim) 343:54-60. 2010
    ..The in-vivo distribution studies showed that these N-malonyl-1,2-dihydroisoquinoline chemical delivery systems were able to cross the blood-brain barrier at detectable concentrations...
  4. ncbi request reprint Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Eur J Med Chem 45:3384-8. 2010
    ..tuberculosis H(37)Rv (IC(90) = 16.87 microg/mL). Details of the structure-activity and structure-cytotoxicity relationships are discussed...
  5. doi request reprint 1-Malonyl-1,4-dihydropyridine as a novel carrier for specific delivery of drugs to the brain
    Heba A Hassan
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Bioorg Med Chem 17:1681-92. 2009
    ..8%, 86.7% and 90.20% of the activity of imipramine, respectively. The other derivatives 9a and 9c exhibited moderate antidepressant activity compared with imipramine...
  6. doi request reprint Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide
    el Shimaa M N Abdel-Hafez
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Bioorg Med Chem 17:3829-37. 2009
    ..In general, structural modification of compound 2 either to nitrate ester or oxime hybrids showed better anti-inflammatory with less ulcerogenic liability than their corresponding starting intermediates...
  7. doi request reprint Design, synthesis and anticancer activity of nitric oxide donating/chalcone hybrids
    Mai A E Mourad
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Eur J Med Chem 54:907-13. 2012
    ..The nitrate ester 3a exhibited moderate selectivity toward colon cancer subpanel with selectivity ratio of 5.87 at TGI level...
  8. doi request reprint New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities
    Mohamed Abdel-Aziz
    Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Bioorg Med Chem 21:3839-49. 2013
    ..The NO-donating oxime 6i revealed significant activity against renal cancer A498 cell lines with 50.52 cell growth inhibition...
  9. ncbi request reprint Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity
    Mohamed Abdel-Aziz
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Eur J Med Chem 69:427-38. 2013
    ..Studying of the solubility and partition coefficient revealed higher lipophilicity of the hybrids 3a-j compared to the parent ciprofloxacin...
  10. doi request reprint Synthesis, anti-inflammatory activity and ulcerogenic liability of novel nitric oxide donating/chalcone hybrids
    Gamal El Din A A Abuo-Rahma
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
    Bioorg Med Chem 20:195-206. 2012
    ..The incorporation of the NO-donating group into the parent chalcone derivatives caused a moderate increase in the anti-inflammatory activity with a marked decrease in gastric ulcerations compared to their parent chalcone derivatives...
  11. doi request reprint 1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities
    Gamal El Din A A Abuo-Rahma
    Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Eur J Med Chem 71:185-98. 2014
    ..Compound 7k was found to be with high selectivity against CNS subpanel with selectivity ratio of 11.99 at GI₅₀ level...
  12. doi request reprint Synthesis and antibacterial activity of 4-aryl-2-(1-substituted ethylidene)thiazoles
    Alaa A Hassan
    Chemistry Department, Faculty of Science, Minia University, El Minia, Egypt
    Arch Pharm (Weinheim) 346:562-70. 2013
    ..05 to 0.4 µg/mL. The rest of the tested compounds gave significant antibacterial activities against different Gram-negative bacterial strains. ..
  13. doi request reprint Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives
    Mai E Shoman
    Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
    Eur J Med Chem 44:3068-76. 2009
    ....
  14. ncbi request reprint Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: Design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies
    Gamal El Din A A Abuo-Rahma
    Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Eur J Med Chem 83:398-408. 2014
    ..The additional H-bonds with the oxygen of the amide and/or H of NH of the amide with the amino acid residues may be responsible for the higher binding affinity of this group of compounds towards COX-2. ..
  15. ncbi request reprint 1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: Synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity
    Mohamed Abdel-Aziz
    Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
    Eur J Med Chem 77:155-65. 2014
    ..2 μM) and 6 (COX-1 IC50 = 39.8 μM; COX-2 IC50 = 46.3 μM) are the most potent COX inhibitors in the tested compounds. The binding mode for some of the tested compounds to the enzymes was predicted using docking studies. ..