Zaigham Abbas

Summary

Publications

  1. doi request reprint Varied presentation of celiac disease in Pakistani adults
    Zaigham Abbas
    Department of Medicine, The Aga Khan University Hospital, Karachi
    J Coll Physicians Surg Pak 23:522-4. 2013
  2. pmc Hepatitis D: Scenario in the Asia-Pacific region
    Zaigham Abbas
    Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan
    World J Gastroenterol 16:554-62. 2010
  3. doi request reprint Terlipressin vs. octreotide in bleeding esophageal varices as an adjuvant therapy with endoscopic band ligation: a randomized double-blind placebo-controlled trial
    Shahab Abid
    Department of Medicine, Aga Khan University, Karachi, Pakistan
    Am J Gastroenterol 104:617-23. 2009
  4. pmc Prevalence of non Helicobacter pylori species in patients presenting with dyspepsia
    Javed Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    BMC Gastroenterol 12:3. 2012
  5. doi request reprint Blastocystis hominis and Dientamoeba fragilis in patients fulfilling irritable bowel syndrome criteria
    Javed Yakoob
    Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
    Parasitol Res 107:679-84. 2010
  6. pmc Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in Pakistan
    Javed Yakoob
    Department of Medicine, Aga Khan University, Karachi, Pakistan
    BMC Gastroenterol 9:87. 2009
  7. pmc Low rate of recurrence of Helicobacter pylori infection in spite of high clarithromycin resistance in Pakistan
    Javed Yakoob
    Department of Medicine, Aga Khan University, Stadium Road, Karachi, 74800, Pakistan
    BMC Gastroenterol 13:33. 2013
  8. pmc Gastric juice for the diagnosis of H pylori infection in patients on proton pump inhibitors
    Javed Yakoob
    Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan
    World J Gastroenterol 14:1539-43. 2008
  9. doi request reprint Short course adjuvant terlipressin in acute variceal bleeding: a randomized double blind dummy controlled trial
    Zahid Azam
    Section of Gastroenterology, Department of Medicine, The Aga Khan University, Karachi, Pakistan
    J Hepatol 56:819-24. 2012
  10. ncbi request reprint Factors predicting in-hospital mortality in patients with cirrhosis hospitalized with gastro-esophageal variceal hemorrhage
    Faisal W Ismail
    Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan
    Indian J Gastroenterol 25:240-3. 2006

Collaborators

Detail Information

Publications47

  1. doi request reprint Varied presentation of celiac disease in Pakistani adults
    Zaigham Abbas
    Department of Medicine, The Aga Khan University Hospital, Karachi
    J Coll Physicians Surg Pak 23:522-4. 2013
    ..In conclusion, celiac disease in adults should be looked for in patients with chronic diarrhea or irritable bowel syndrome like symptoms, underweight, anaemic, or having nutritional deficiencies...
  2. pmc Hepatitis D: Scenario in the Asia-Pacific region
    Zaigham Abbas
    Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan
    World J Gastroenterol 16:554-62. 2010
    ..Intravenous drug abusers, homosexual men and women, prostitutes, and people on hemodialysis are the groups with very high HDV prevalence...
  3. doi request reprint Terlipressin vs. octreotide in bleeding esophageal varices as an adjuvant therapy with endoscopic band ligation: a randomized double-blind placebo-controlled trial
    Shahab Abid
    Department of Medicine, Aga Khan University, Karachi, Pakistan
    Am J Gastroenterol 104:617-23. 2009
    ..The aim of this study was to compare the efficacy and safety of terlipressin with octreotide as an adjuvant therapy to endoscopic variceal band ligation in patients with esophageal variceal bleeding...
  4. pmc Prevalence of non Helicobacter pylori species in patients presenting with dyspepsia
    Javed Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    BMC Gastroenterol 12:3. 2012
    ..pylori phosphoglucosamine mutase (glmM) and urease B (ureB) gene of H. heilmannii and H. felis. Sequencing of PCR products of H. heilmannii and H. felis was done...
  5. doi request reprint Blastocystis hominis and Dientamoeba fragilis in patients fulfilling irritable bowel syndrome criteria
    Javed Yakoob
    Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
    Parasitol Res 107:679-84. 2010
    ..030). B. hominis is common, while D. fragilis was less prevalent in our patients with IBS-D. B. hominis and D. fragilis culture had a better yield compared to stool microscopy and PCR...
  6. pmc Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in Pakistan
    Javed Yakoob
    Department of Medicine, Aga Khan University, Karachi, Pakistan
    BMC Gastroenterol 9:87. 2009
    ..pylori virulence markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA) alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma (GC) and duodenal ulcer (DU)...
  7. pmc Low rate of recurrence of Helicobacter pylori infection in spite of high clarithromycin resistance in Pakistan
    Javed Yakoob
    Department of Medicine, Aga Khan University, Stadium Road, Karachi, 74800, Pakistan
    BMC Gastroenterol 13:33. 2013
    ..The aim was to investigate the reinfection rate of H. pylori during a follow-up period of 12 months in adults who had undergone eradication therapy...
  8. pmc Gastric juice for the diagnosis of H pylori infection in patients on proton pump inhibitors
    Javed Yakoob
    Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan
    World J Gastroenterol 14:1539-43. 2008
    ..To determine the efficacy of gastric juice polymerase chain reaction (PCR) for the detection of H pylori infection in comparison with histology and gastric antral biopsy PCR in patients on a proton pump inhibitor (PPI)...
  9. doi request reprint Short course adjuvant terlipressin in acute variceal bleeding: a randomized double blind dummy controlled trial
    Zahid Azam
    Section of Gastroenterology, Department of Medicine, The Aga Khan University, Karachi, Pakistan
    J Hepatol 56:819-24. 2012
    ..Terlipressin is recommended for 3-5 days as adjuvant to endoscopic variceal band ligation (EVBL) in esophageal variceal bleeding (EVB). We assessed whether terlipressin can be administered for a shorter period of time to patients with EVB...
  10. ncbi request reprint Factors predicting in-hospital mortality in patients with cirrhosis hospitalized with gastro-esophageal variceal hemorrhage
    Faisal W Ismail
    Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan
    Indian J Gastroenterol 25:240-3. 2006
    ..To identify factors at the time of admission that predict in-hospital mortality in patients with gastro-esophageal variceal hemorrhage...
  11. doi request reprint Efficacy of L-ornithine-L-aspartate as an adjuvant therapy in cirrhotic patients with hepatic encephalopathy
    Shahab Abid
    Department of Medicine, The Aga Khan University Hospital, Karachi
    J Coll Physicians Surg Pak 21:666-71. 2011
    ..To evaluate the efficacy of L-ornithine-L-aspartate (LOLA) as an adjuvant therapy in cirrhotic patients with hepatic encephalopathy (HE)...
  12. ncbi request reprint An office-based serological test for detection of current Helicobacter pylori infection: is it useful?
    Khalid Mumtaz
    Section of Gastroenterology, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
    Eur J Gastroenterol Hepatol 18:85-8. 2006
    ..To compare the accuracy of a new office-based serological test for the detection of current Helicobacter pylori infection with gastric histopathology...
  13. ncbi request reprint The diagnostic yield of various tests for Helicobacter pylori infection in patients on acid-reducing drugs
    Javed Yakoob
    Department of Gastroenterology and Pathology, Aga Khan University Hospital, Karachi, Pakistan
    Dig Dis Sci 53:95-100. 2008
    ..8; 95% CI: 0.4-7.8; P = 0.342). For those patients on PPIs, the diagnostic yield of both RUT and histology was reduced from both the antrum and corpus. In these patients, PCR for H. pylori is more sensitive than RUT and histology...
  14. doi request reprint Furazolidone, co-amoxiclav, colloidal bismuth subcitrate, and esomeprazole for patients who failed to eradicate Helicobacter pylori with triple therapy
    Zaigham Abbas
    Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan
    Dig Dis Sci 54:1953-7. 2009
    ..On an intention-to-treat analysis, the eradication rate was 81% (42 out of 52) whereas on per-protocol basis, the eradication rate was 82.4% (42 out of 51). In conclusion, this new regimen represents a suitable second-line therapy...
  15. ncbi request reprint Clinical presentation and genotype of hepatitis delta in Karachi
    Tariq Moatter
    Department of Pathology, The Aga Khan University Hospital, Karachi, Pakistan
    World J Gastroenterol 13:2604-7. 2007
    ..To assess the clinical presentation and genotypes of delta hepatitis in local population...
  16. pmc Hepatocellular carcinoma in hepatitis D: does it differ from hepatitis B monoinfection?
    Zaigham Abbas
    Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
    Saudi J Gastroenterol 18:18-22. 2012
    ..The aim of this study was to compare clinical aspects of hepatocellular carcinoma in patients of hepatitis D with HBV monoinfection...
  17. doi request reprint In vitro sensitivity of Blastocystis hominis to garlic, ginger, white cumin, and black pepper used in diet
    Javed Yakoob
    Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan
    Parasitol Res 109:379-85. 2011
    ..01 mg/ml of MTZ. However, this sensitivity did not increase as garlic concentration was increased to 0.1 mg/ml, for B. hominis cell count was 6,000 compared to 1,428 as MTZ was increased to 0.1 mg/ml...
  18. pmc Small intestinal bacterial overgrowth and lactose intolerance contribute to irritable bowel syndrome symptomatology in Pakistan
    Javed Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Saudi J Gastroenterol 17:371-5. 2011
    ..The aim of this study was to determine the frequency of SIBO and lactose intolerance (LI) occurrence in patients with diarrhea-predominant irritable bowel syndrome (IBS-D) according to Rome III criteria...
  19. doi request reprint Irritable bowel syndrome: is it associated with genotypes of Blastocystis hominis
    Javed Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Parasitol Res 106:1033-8. 2010
    ..30), respectively. Majority of our patients had typeable B. hominis infection. The genotype of B. hominis in IBS-D was type 1 while in control genotype 3 was predominant...
  20. ncbi request reprint Randomized controlled trial of interferon gamma versus amantadine in combination with interferon alpha and ribavirin for hepatitis C genotype 3 non-responders and relapsers
    Zaigham Abbas
    Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
    J Pak Med Assoc 62:338-43. 2012
    ....
  21. pmc Cost saving by reloading the multiband ligator in endoscopic esophageal variceal ligation: a proposal for developing countries
    Zaigham Abbas
    Department of Medicine, The Aga Khan University Hospital Stadium Road, Karachi 74800, Pakistan
    World J Gastroenterol 14:2222-5. 2008
    ..To assess the cost savings of reloading the multiband ligator in endoscopic esophageal variceal ligation (EVL) used on the same patient for subsequent sessions...
  22. pmc Acceptability and outcomes of the Percutaneous Endoscopic Gastrostomy (PEG) tube placement--patients' and care givers' perspectives
    Muhammad K Anis
    Department of Medicine, Section Gastroenterology, Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan
    BMC Gastroenterol 6:37. 2006
    ..Our aim of the study was to assess the outcome and perspectives of patients/care givers, about the acceptability of percutaneous endoscopic gastrostomy tube placement...
  23. ncbi request reprint Coeliac disease and multiple immunodeficiencies: case report of a diagnostic dilemma
    Sabiha Anis
    Department of Molecular Biology and Immunology, Dewan Farooq Medical Centre, Sindh Institute of Urology and Transplantation, Karachi, Pakistan
    J Pak Med Assoc 62:730-2. 2012
    ..The patient eventually succumbed to recurrent infections. The co-existence of PID is unusual in a patient with CD. This case report highlights the importance of investigating PID in patients with autoimmunity...
  24. pmc Role of rapid urease test and histopathology in the diagnosis of Helicobacter pylori infection in a developing country
    Javed Yakoob
    Department of Gastroenterology and Pathology, Aga Khan University Hospital, Karachi, Pakistan
    BMC Gastroenterol 5:38. 2005
    ..The aim of this study was to determine the effect of commonly self-prescribed proton pump inhibitors (PPI) on the results of rapid urease test and histology for the diagnosis of H. pylori infection...
  25. pmc Noninvasive predictors of large varices in patients hospitalized with gastroesophageal variceal hemorrhage
    Faisal Wasim Ismail
    Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Karachi, 74800, Pakistan
    Hepatol Int 2:124-8. 2008
    ..To identify noninvasive factors predicting the presence of large varices (LV) in patients hospitalized with gastroesophageal variceal hemorrhage (GEVH)...
  26. ncbi request reprint Outcome of endoscopic therapeutic interventions: are they different among various non-malignant esophageal diseases
    Rustam Khan
    Section of Gastroenterology Department of Medicine The Aga Khan University Hospital, Karachi, Pakistan
    J Ayub Med Coll Abbottabad 17:22-5. 2005
    ..This study was carried out to evaluate and compare the outcome of various causes of non-malignant lesions of the esophagus after endoscopic therapeutic intervention...
  27. doi request reprint Management of hepatitis B: Pakistan Society for the Study of Liver Diseases (PSSLD) practice guidelines
    Zaigham Abbas
    Department of Medicine, Sindh Institute of Urology and Transplantation, Karachi
    J Coll Physicians Surg Pak 20:198-201. 2010
    ..In HBeAg negative patients, discontinuation may be considered if undetectable HBV-DNA has been documented on three separate occasions 6 months apart although current evidence seems to support long term therapy in this group...
  28. ncbi request reprint Esophageal polypoidal mass: presentation of an uncommon pleomorphic carcinoma
    Javed Yakoob
    Department of Medicine and Pathology, The Aga Khan University, Karachi, Pakistan
    J Pak Med Assoc 59:639-41. 2009
    ..To our knowledge this is the first local report of spindle cell carcinoma occurring in the esophagus and describes its endoscopic and histopathological features with distinctive biphasic morphology...
  29. ncbi request reprint Endoscopic management of biliary leaks after open and laparoscopic cholecystectomy
    Mohammad Salih
    Department of Medicine, The Aga Khan University Hospital, Karachi
    J Pak Med Assoc 57:117-9. 2007
    ..To evaluate the diagnostic and therapeutic efficacy of ERCP in the management of biliary leaks...
  30. pmc Predictive factors for early aspiration in liver abscess
    Rustam Khan
    Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan
    World J Gastroenterol 14:2089-93. 2008
    ..To determine the predictive factors for early aspiration in liver abscess...
  31. pmc Associations between the Plasticity Region Genes of Helicobacter pylori and Gastroduodenal Diseases in a High-Prevalence Area
    Javed Yakoob
    Department of Medicine, The Aga Khan University, Karachi, Pakistan
    Gut Liver 4:345-50. 2010
    ..pylori) plasticity region may play a role in the pathogenesis of H. pylori. We compared the genes jhp0940, jhp0947, and jhp0986 in H. pylori isolates from patients with different gastroduodenal diseases and in different age groups...
  32. doi request reprint Gastric corpus polyps associated with Proton Pump Inhibitors therapy
    Javed Yakoob
    Department of Medicine, The Aga Khan University Hospital, Karachi
    J Coll Physicians Surg Pak 18:172-3. 2008
    ..pylori was also negative. This is the first report originating from an Asian country describing Fundal Gland Polyps (FGPs) in the corpus of stomach rather than fundus in a patient on long-term PPI therapy...
  33. ncbi request reprint Is Crohn's disease in Pakistan less severe than in the West?
    Zaigham Abbas
    Department of Medicine, The Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan
    Trop Doct 34:39-41. 2004
  34. ncbi request reprint Sclerotherapy plus octreotide versus sclerotherapy alone in the management of gastro-oesophageal variceal hemorrhage
    Hasnain A Shah
    Section of Gastroenterology, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
    J Ayub Med Coll Abbottabad 17:10-4. 2005
    ..In this study we compare efficacy of octreotide (50 g/hr for 48 hours) combined with sclerotherapy versus sclerotherapy alone in patients with acute bleeding from gastro-oesophageal varices (GOV)...
  35. ncbi request reprint Three years old child with juvenile hyaline fibromatosis presenting with rectal bleeding
    Kapeel Raja
    Department of Hepatogastroenterlogy, Sindh Institute of Urology and Transplantation, Karachi, Pakistan
    J Pak Med Assoc 63:396-8. 2013
    ..Excision of the anal lesion revealed histopathological features of Juvenile Hyaline Fibromatosis...
  36. ncbi request reprint Diagnostic dilemma of abdominal tuberculosis in non-HIV patients: an ongoing challenge for physicians
    Rustam Khan
    Department of Medicine, Aga Khan University Hospital, National Stadium Road, Karachi 74800, Pakistan
    World J Gastroenterol 12:6371-5. 2006
    ..To assess the clinical features, yield of the diagnostic tests and outcome of abdominal tuberculosis in non-HIV patients...
  37. ncbi request reprint Interferon alpha for chronic hepatitis D
    Zaigham Abbas
    Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Diwan Complex, Chand Bibi Road, Karachi, Sindh, Pakistan
    Cochrane Database Syst Rev 12:CD006002. 2011
    ..However, there are few randomised trials evaluating the effects of interferon alpha, and it is difficult to judge any benefit of this intervention from the individual trials...
  38. ncbi request reprint Prognostic factors of survival in patients with non-resectable hepatocellular carcinoma: hepatitis C versus miscellaneous etiology
    Zaigham Abbas
    Department of Hepatogastroenterology, Sindh Institute of Urolgy and Transplantation SIUT, Karachi, Pakistan
    J Pak Med Assoc 58:602-7. 2008
    ....
  39. ncbi request reprint HELICOBACTER PYLORI, HEPATITIS VIRUSES A, C, E, ANTIBODIES AND HBsAg - PREVALENCE AND ASSOCIATED RISK FACTORS IN PEDIATRIC COMMUNITIES OF KARACHI
    Sina Aziz
    Department of Pediatrics, Dow University of Health Sciences, Karachi, Pakistan
    J Coll Physicians Surg Pak 17:195-8. 2007
    ..Conclusion: With age, increasing number of children acquired antibodies against hepatotropic viruses and H. pylori. Occurrence of HBsAg and anti-HEV at a later age suggests horizontal, rather than vertical transmission...
  40. ncbi request reprint Adverse events following transarterial chemoembolization for hepatocellular carcinoma and factors predicting such events
    Abbas Ali Tasneem
    Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation SLUT, Karachi, Pakistan
    J Pak Med Assoc 63:239-44. 2013
    ..To document the adverse events after transarterial chemoembolisation and factors predicting such events...
  41. ncbi request reprint Carcinoma of the esophagus: are we different?
    Mohammad Salih
    Department of Medicine, Section of Gastroenterology, The Aga Khan University Hospital, Karachi
    J Coll Physicians Surg Pak 15:313-4. 2005
  42. ncbi request reprint Is there any association of extra hepatic biliary atresia with cytomegalovirus or other infections?
    Ghous Bukhsh Soomro
    Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi
    J Pak Med Assoc 61:281-3. 2011
    ..Eleven of these also had positive CMV IgM antibodies. No other above mentioned infections could be detected in our patients of EHBA. Our data suggests that CMV infection may play a role in the pathogenesis and progression of EHBA...
  43. pmc Genetic variability in the precore and core promoter regions of hepatitis B virus strains in Karachi
    Zaigham Abbas
    Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan
    BMC Gastroenterol 6:20. 2006
    ..The local prevalence of HBV genotypes and mutations has not been well studied. The aim of the present study is to determine the prevalence of HBV genotypes and mutations in the PC and BCP region in HBV strains in Karachi...
  44. ncbi request reprint Systematic reviews and their role in evidence-informed health care
    Zaigham Abbas
    SIUT, Karachi, Pakistan
    J Pak Med Assoc 58:561-7. 2008
    ..A reader should first be able to evaluate the quality of a systematic review before practicing the evidence provided by it as it helps to practice the provided evidence more effectively...
  45. ncbi request reprint Thalamic and midbrain infarct during transarterial chemoembolization of hepatocellular carcinoma
    Rajesh Kumar
    Department of Hepatogastroentrology, Sindh Institute of Urology and Transplantation SIUT, Karachi, Pakistan
    J Pak Med Assoc 62:295-7. 2012
    ..The possible explanation could be an aberrant connection between the hepatic and pulmonary vessels which might have developed due to the involvement of the diaphragm, pleura and pulmonary vessels after the first session of TACE...
  46. ncbi request reprint Effect of cytokine gene polymorphism on histological activity index, viral load and response to treatment in patients with chronic hepatitis C genotype 3
    Zaigham Abbas
    Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
    World J Gastroenterol 11:6656-61. 2005
    ..To investigate the association between cytokine gene polymorphism and disease status in chronic hepatitis C genotype 3 by liver biopsy, ALT, HCV RNA levels and response to treatment...
  47. pmc Hepatocellular carcinoma in pakistan: where do we stand?
    Amna Subhan Butt
    Section of Gastroenterology, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
    Hepat Mon 12:e6023. 2012
    ..There was an increase in the proportion of non-B non-C (NBNC) HCC cases as well, which might be attributed to an increase in non-alcoholic fatty liver disease...