D Aarsland

Summary

Publications

  1. doi request reprint Clinical trials of dementia with Lewy bodies and Parkinson's disease dementia
    D Aarsland
    Alzheimer s Disease Research Centre, Novum, Karolinska Institutet, 141 86 Stockholm, Sweden
    Curr Neurol Neurosci Rep 12:492-501. 2012
  2. doi request reprint Depression in Parkinson disease--epidemiology, mechanisms and management
    Dag Aarsland
    Karolinska Institute, Alzheimer s Disease Research Center, Novum, 141 86 Stockholm, Sweden
    Nat Rev Neurol 8:35-47. 2012
  3. doi request reprint The epidemiology of dementia associated with Parkinson disease
    Dag Aarsland
    The Norwegian Centre for Movement Disorders Psychiatric Clinic, Stavanger University Hospital, Stavanger, Norway
    J Neurol Sci 289:18-22. 2010
  4. doi request reprint Mild cognitive impairment in Parkinson's disease
    Dag Aarsland
    Centre for Age Related Diseases, Division of Psychiatry, Stavanger University Hospital, Stavanger, Norway
    Curr Neurol Neurosci Rep 11:371-8. 2011
  5. doi request reprint Nonlinear decline of mini-mental state examination in Parkinson's disease
    Dag Aarsland
    Centre for Age Related Medicine, Division of Psychiatry, Stavanger University Hospital, Stavanger, Norway
    Mov Disord 26:334-7. 2011
  6. pmc Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis
    D Aarsland
    Stavanger University Hospital, Psychiatric Division, PO Box 8100, 4068 Stavanger, Norway
    Neurology 75:1062-9. 2010
  7. doi request reprint Early discriminatory diagnosis of dementia with Lewy bodies. The emerging role of CSF and imaging biomarkers
    Dag Aarsland
    Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    Dement Geriatr Cogn Disord 25:195-205. 2008
  8. doi request reprint The epidemiology of dementia associated with Parkinson's disease
    Dag Aarsland
    Department of Psychiatry, Stavanger University Hospital, Postboks 8100, 4068 Stavanger, Norway
    Brain Pathol 20:633-9. 2010
  9. doi request reprint Is physical activity a potential preventive factor for vascular dementia? A systematic review
    Dag Aarsland
    King s College London, Wolfson Centre for Age Related Diseases, Guy s Campus, London, UK
    Aging Ment Health 14:386-95. 2010
  10. pmc Neuropsychiatric symptoms in Parkinson's disease
    Dag Aarsland
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    Mov Disord 24:2175-86. 2009

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. doi request reprint Clinical trials of dementia with Lewy bodies and Parkinson's disease dementia
    D Aarsland
    Alzheimer s Disease Research Centre, Novum, Karolinska Institutet, 141 86 Stockholm, Sweden
    Curr Neurol Neurosci Rep 12:492-501. 2012
    ..In addition, there is a need for studies of whether potentially disease-modifying agents can prevent or delay the progression to dementia in PD...
  2. doi request reprint Depression in Parkinson disease--epidemiology, mechanisms and management
    Dag Aarsland
    Karolinska Institute, Alzheimer s Disease Research Center, Novum, 141 86 Stockholm, Sweden
    Nat Rev Neurol 8:35-47. 2012
    ..This Review describes the frequency and course of depression in patients with PD. The mechanisms that underlie depression in this disease are also discussed, and the management strategies for these patients are highlighted...
  3. doi request reprint The epidemiology of dementia associated with Parkinson disease
    Dag Aarsland
    The Norwegian Centre for Movement Disorders Psychiatric Clinic, Stavanger University Hospital, Stavanger, Norway
    J Neurol Sci 289:18-22. 2010
    ..The genetic contributions to dementia are currently not clear and need to be explored in future studies...
  4. doi request reprint Mild cognitive impairment in Parkinson's disease
    Dag Aarsland
    Centre for Age Related Diseases, Division of Psychiatry, Stavanger University Hospital, Stavanger, Norway
    Curr Neurol Neurosci Rep 11:371-8. 2011
    ..PD-MCI predicts a shorter time to dementia, and preliminary evidence suggests that this is particularly true for posterior cognitive deficits. There are currently no systematic clinical trials in PD-MCI...
  5. doi request reprint Nonlinear decline of mini-mental state examination in Parkinson's disease
    Dag Aarsland
    Centre for Age Related Medicine, Division of Psychiatry, Stavanger University Hospital, Stavanger, Norway
    Mov Disord 26:334-7. 2011
    ..This inflection point was estimated to occur 13.3 years (95% credible interval 11.8, 13.6) after the diagnosis of PD; however, there were wide interindividual variations in the time from onset of PD to the inflection point...
  6. pmc Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis
    D Aarsland
    Stavanger University Hospital, Psychiatric Division, PO Box 8100, 4068 Stavanger, Norway
    Neurology 75:1062-9. 2010
    ..In studies of mild cognitive impairment (MCI) in Parkinson disease (PD), patients without dementia have reported variable prevalences and profiles of MCI, likely to be due to methodologic differences between the studies...
  7. doi request reprint Early discriminatory diagnosis of dementia with Lewy bodies. The emerging role of CSF and imaging biomarkers
    Dag Aarsland
    Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    Dement Geriatr Cogn Disord 25:195-205. 2008
    ..Our aim was to identify biomarkers that may differentiate DLB from Alzheimer's disease (AD)...
  8. doi request reprint The epidemiology of dementia associated with Parkinson's disease
    Dag Aarsland
    Department of Psychiatry, Stavanger University Hospital, Postboks 8100, 4068 Stavanger, Norway
    Brain Pathol 20:633-9. 2010
    ..The purpose of this review is to present recent findings on clinical aspects of dementia in PD and to elucidate underlying clinical and neurobiological risk factors...
  9. doi request reprint Is physical activity a potential preventive factor for vascular dementia? A systematic review
    Dag Aarsland
    King s College London, Wolfson Centre for Age Related Diseases, Guy s Campus, London, UK
    Aging Ment Health 14:386-95. 2010
    ..Although several studies of potential risk factors for vascular dementia (VaD) exist, including physical activity, the studies have usually included few participants and there are no meta-analyses addressing this key topic...
  10. pmc Neuropsychiatric symptoms in Parkinson's disease
    Dag Aarsland
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    Mov Disord 24:2175-86. 2009
    ..There is thus an urgent need for systematic studies for the pharmacological and non-pharmacological management of these symptoms...
  11. doi request reprint The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson's disease
    D Aarsland
    Stavanger University Hospital, The Norwegian Centre for Movement Disorders, PO Box 8100, 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 80:928-30. 2009
    ..Neuropsychiatric symptoms are common in Parkinson's disease (PD) and have important clinical consequences for patients, caregivers and society. Few studies of neuropsychiatric symptoms in early untreated PD exist...
  12. ncbi request reprint Occurrence and clinical correlates of REM sleep behaviour disorder in patients with Parkinson's disease over time
    M D Gjerstad
    The Norwegian Centre for Movement Disorders, Stavanger, Norway, PB 8100, N 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 79:387-91. 2008
    ..To examine the occurrence and clinical and demographic correlates of REM sleep behaviour disorder (RBD) in patients with Parkinson's disease (PD) in a community-based cohort over 8 years...
  13. doi request reprint Neuropsychiatric symptoms in mild dementia with lewy bodies and Alzheimer's disease
    J Bjoerke-Bertheussen
    Department of Psychiatry, Centre for Age Related Medicine, Stavanger University Hospital, Stavanger, Norway
    Dement Geriatr Cogn Disord 34:1-6. 2012
    ..To compare neuropsychiatric symptoms in patients with Alzheimer's disease (AD) and dementia with Lewy bodies(DLB)...
  14. pmc Neuropsychiatric symptoms in patients with Parkinson's disease and dementia: frequency, profile and associated care giver stress
    D Aarsland
    Centre for Clinical Neuroscience Research, Stavanger University Hospital, Stavanger, Norway
    J Neurol Neurosurg Psychiatry 78:36-42. 2007
    ..To explore the profile of neuropsychiatric symptoms in patients with dementia associated with Parkinson's disease (PDD)...
  15. doi request reprint Cognitive impairment in incident, untreated Parkinson disease: the Norwegian ParkWest study
    D Aarsland
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, PO 8100, N 4068 Stavanger, Norway
    Neurology 72:1121-6. 2009
    ..The aim of this study was to explore the proportion with mild cognitive impairment (MCI) and subtypes in an incidence cohort of untreated PD in Southern and Western Norway...
  16. doi request reprint Dementia and survival in Parkinson disease: a 12-year population study
    T C Buter
    Section of Geriatric Psychiatry, Stavanger University Hospital, Arm Hansen v 20, N 4095 Stavanger, Norway
    Neurology 70:1017-22. 2008
    ..However, the absolute risk of dementia and how it affects survival in PD are not known. Such questions are important for patients, their families, and service providers but require long-term studies...
  17. pmc Range of neuropsychiatric disturbances in patients with Parkinson's disease
    D Aarsland
    Section of Geriatric Psychiatry, Rogaland Psychiatric Hospital, Stavanger, Norway
    J Neurol Neurosurg Psychiatry 67:492-6. 1999
    ..The objective of this study was to describe the range of neuropsychiatric symptoms in a representative sample of patients with Parkinson's disease...
  18. doi request reprint Incidence of Parkinson's disease in Norway: the Norwegian ParkWest study
    G Alves
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, PO Box 8100, N 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 80:851-7. 2009
    ....
  19. ncbi request reprint Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease?
    M D Gjerstad
    Norwegian Centre for Movement Disorders, Department of Neurology, Stavanger University Hospital, Stavanger, Norway
    Neurology 67:853-8. 2006
    ..To examine associated demographic and clinical correlates and the development of excessive daytime sleepiness (EDS) over 8 years in a community-based cohort of patients with Parkinson disease (PD)...
  20. pmc Performance on the dementia rating scale in Parkinson's disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer's disease
    D Aarsland
    Section of Geriatric Psychiatry, Psychiatric Clinic, Central Hospital of Rogaland, Stavanger, and School of Medicine, University of Bergen, Norway
    J Neurol Neurosurg Psychiatry 74:1215-20. 2003
    ..The relation between dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) is unknown...
  21. ncbi request reprint Neuropsychiatric disturbances in Parkinson's disease clusters in five groups with different prevalence of dementia
    K Bronnick
    Section of Geriatric Psychiatry, Stavanger University Hospital, Helse Stavanger, Norway
    Acta Psychiatr Scand 112:201-7. 2005
    ..To investigate the inter-relationship of neuropsychiatric disturbances in Parkinson's disease (PD) by cluster analysis and describe the properties of the clusters...
  22. ncbi request reprint The influence of cerebrovascular risk factors on incident dementia in patients with Parkinson's disease
    K Haugarvoll
    The Norwegian Centre for Movement Disorders, Rogaland Central Hospital, Stavanger, Norway
    Acta Neurol Scand 112:386-90. 2005
    ..To examine if risk factors for cerebrovascular disease would increase the risk for dementia in patients with Parkinson's disease (PD)...
  23. doi request reprint Nursing home structure and association with agitation and use of psychotropic drugs in nursing home residents in three countries: Norway, Austria and England
    I Testad
    Psychiatric Clinic, Stavanger University Hospital, Stavanger, Norway
    Int J Geriatr Psychiatry 25:725-31. 2010
    ..International comparative studies offer special advantages in elucidating environmental risk factors by providing a wider diversity of environmental exposures such as nursing home structures, health care systems and genetic diversity...
  24. doi request reprint Caregiver distress associated with neuropsychiatric problems in patients with early Parkinson's disease: the Norwegian ParkWest study
    Ingrid Leiknes
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    Acta Neurol Scand 122:418-24. 2010
    ..We investigated caregiver distress associated with neuropsychiatric problems in patients with newly diagnosed Parkinson's disease (PD)...
  25. ncbi request reprint A comparative study of psychiatric symptoms in dementia with Lewy bodies and Parkinson's disease with and without dementia
    D Aarsland
    Section of Geriatric Psychiatry, Rogaland Psychiatric Hospital, Stavanger, Norway
    Int J Geriatr Psychiatry 16:528-36. 2001
    ..To compare the frequency and clinical correlates of neuropsychiatric symptoms in patients with Parkinson's disease (PD) with and without dementia and in those with dementia with Lewy bodies (DLB)...
  26. ncbi request reprint Risk of dementia in Parkinson's disease: a community-based, prospective study
    D Aarsland
    Section of Geriatric Psychiatry, Rogaland Psychiatric Hospital, Stavanger, Norway
    Neurology 56:730-6. 2001
    ..To calculate the incidence of and determine possible risk factors for dementia in PD...
  27. ncbi request reprint Prevalence and clinical correlates of psychotic symptoms in Parkinson disease: a community-based study
    D Aarsland
    Section of Geriatric Psychiatry, Rogaland Psychiatric Hospital, Stavanger, Norway
    Arch Neurol 56:595-601. 1999
    ..However, the prevalence and clinical features of these symptoms have not been studied in a representative sample...
  28. ncbi request reprint Olanzapine for psychosis in patients with Parkinson's disease with and without dementia
    D Aarsland
    Section of Geriatric Psychiatry, Rogaland Psychiatric Hospital, Stavanger, Norway
    J Neuropsychiatry Clin Neurosci 11:392-4. 1999
    ..Six subjects (29%) discontinued treatment prematurely because of drowsiness. Delusions and hallucinations improved significantly, and 80% were rated as much or very much improved. There was no worsening of parkinsonism or cognition...
  29. doi request reprint Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study
    K F Pedersen
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, PO Box 8100, N 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 80:1279-82. 2009
    ..Apathy is a common but under-recognised behavioural disorder associated with depression and cognitive impairment in patients with Parkinson disease (PD). However, the longitudinal course of apathy in PD has not been studied...
  30. doi request reprint Relationship of cognitive impairment to psychiatric symptoms in multiple sclerosis
    N Figved
    Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway
    Mult Scler 14:1084-90. 2008
    ..The association between apathy and intrusions supports the hypothesis that lesions in frontal areas or frontal connections contribute to a specific neuropsychiatric syndrome in patients with MS...
  31. pmc Attentional deficits affect activities of daily living in dementia-associated with Parkinson's disease
    K Bronnick
    Psychiatric Clinic, Stavanger University Hospital, Helse Stavanger, Post Box 8100, 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 77:1136-42. 2006
    ..To investigate the effects of attentional deficits on activities of daily living (ADL) in patients with dementia associated with Parkinson's disease (PDD)...
  32. doi request reprint Health and well-being in care staff and their relations to organizational and psychosocial factors, care staff and resident factors in nursing homes
    I Testad
    Stavanger University Hospital, Psychiatric Clinic, Stavanger, Norway
    Int J Geriatr Psychiatry 25:789-97. 2010
    ..The aim of this study is to investigate the association of psychosocial factors and patient factors with stress in care staff in nursing homes...
  33. ncbi request reprint The effect of age of onset of PD on risk of dementia
    D Aarsland
    Norwegian Centre for Movement Disorders, Stavanger University Hospital, Arm Hansen v 20, N 4005, Stavanger, Norway
    J Neurol 254:38-45. 2007
    ..However, age at onset (AAO) and age at baseline assessment are often correlated. The aim of this study was to explore whether AAO of PD symptoms is a risk factor for dementia independent of the general effect of age...
  34. pmc Insomnia in Parkinson's disease: frequency and progression over time
    M D Gjerstad
    Department of Neurology, Stavanger University Hospital, Stavanger, Norway
    J Neurol Neurosurg Psychiatry 78:476-9. 2007
    ..To examine the development of nocturnal sleeping problems in patients with Parkinson's disease (PD) over an 8-year period and to study the clinical and demographic correlates of insomnia...
  35. ncbi request reprint Comparison of extrapyramidal signs in dementia with Lewy bodies and Parkinson's disease
    D Aarsland
    Section of Geriatric Psychiatry, Rogaland Psychiatric Hospital, Stavanger, Norway
    J Neuropsychiatry Clin Neurosci 13:374-9. 2001
    ..Severity of EPS correlated with age, duration of disease, and cognitive impairment in PD patients but not in DLB patients. Studies of the clinical significance and management of EPS in DLB patients are needed...
  36. ncbi request reprint Cognitive, psychiatric and motor response to galantamine in Parkinson's disease with dementia
    D Aarsland
    Section of Geriatric Psychiatry, Rogaland Central Hospital, Stavanger, Norway
    Int J Geriatr Psychiatry 18:937-41. 2003
    ....
  37. ncbi request reprint Mental symptoms in Parkinson's disease are important contributors to caregiver distress
    D Aarsland
    Rogaland Psychiatric Hospital, Stavanger, Norway
    Int J Geriatr Psychiatry 14:866-74. 1999
    ..To determine the emotional and social distress of caring for a patient with Parkinson's disease and to explore the impact of motor and mental symptoms in subjects with Parkinson's disease on their caregivers' situation...
  38. pmc Caregiver burden in multiple sclerosis: the impact of neuropsychiatric symptoms
    Nanna Figved
    Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway
    J Neurol Neurosurg Psychiatry 78:1097-102. 2007
    ..We studied the level of distress in caregivers of patients with recently diagnosed multiple sclerosis (MS), and their relation to clinical characteristics...
  39. ncbi request reprint Neuroleptic sensitivity in Parkinson's disease and parkinsonian dementias
    Dag Aarsland
    Section of Geriatric Psychiatry, Central Hospital, Rogaland, Stavanger, Norway
    J Clin Psychiatry 66:633-7. 2005
    ..Severe sensitivity to neuroleptic agents is a major clinical problem in dementia with Lewy bodies (DLB), but has not been determined in Parkinson's disease (PD) and PD with dementia (PDD)...
  40. doi request reprint Apathy in drug-naïve patients with incident Parkinson's disease: the Norwegian ParkWest study
    Kenn Freddy Pedersen
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, PO Box 8100, 4068, Stavanger, Norway
    J Neurol 257:217-23. 2010
    ..Future studies should explore the longitudinal effect of dopamine replacement therapy on apathetic behaviour in early PD. The relationship between apathy and male gender needs further study to be fully evaluated...
  41. ncbi request reprint Progression of motor impairment and disability in Parkinson disease: a population-based study
    Guido Alves
    Norwegian Centre for Movement Disorders, Stavanger, Norway
    Neurology 65:1436-41. 2005
    ..To investigate risk factors and the rate of progression of motor symptoms and disability in a population-based cohort of patients with Parkinson disease (PD)...
  42. ncbi request reprint Cognitive profiles of individual patients with Parkinson's disease and dementia: comparison with dementia with lewy bodies and Alzheimer's disease
    Carmen Cristea Janvin
    Stavanger University Hospital, Section of Geriatric Psychiatry, Stavanger, Norway
    Mov Disord 21:337-42. 2006
    ..These findings suggest that in some patients with PDD, frontosubcortical changes are the main contributing factor to dementia, whereas in other patients, cortical and hippocampal changes are more important...
  43. ncbi request reprint Development of daytime somnolence over time in Parkinson's disease
    M D Gjerstad
    Department of Neurology, Central Hospital of Rogaland, Stavanger, Norway
    Neurology 58:1544-6. 2002
    ..During follow-up, 30 new patients had EDS (6% new patients per year). In 1997, 29% of the patients with PD had EDS. The development of EDS correlated with more advanced disease and dementia...
  44. ncbi request reprint Familial Parkinson's disease: a community-based study
    M Kurz
    Department of Neurology, Central Hospital of Rogaland, Stavanger, Norway
    Eur J Neurol 10:159-63. 2003
    ..Our results indicate that the familial aggregation of the disease is independent of the age of the proband...
  45. doi request reprint Use of drugs with anticholinergic effect and impact on cognition in Parkinson's disease: a cohort study
    Uwe Ehrt
    Stavanger University Hospital, Psychiatric Clinic, PO Box 1163, Hillevag, 4095 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 81:160-5. 2010
    ..Such knowledge would provide opportunities to prevent acceleration of cognitive decline in PD...
  46. doi request reprint Frequency and case identification of dementia with Lewy bodies using the revised consensus criteria
    Dag Aarsland
    Department of Old Age Psychiatry, Stavanger University Hospital, Bergen, Norway
    Dement Geriatr Cogn Disord 26:445-52. 2008
    ..To find the proportion of dementia with Lewy bodies (DLB) in a referral cohort of patients with a first-time diagnosis of mild dementia...
  47. ncbi request reprint Neuropsychological profile of patients with Parkinson's disease without dementia
    Carmen Janvin
    Section of Geriatric Psychiatry, Rogaland Psychiatric Hospital, Stavanger, Norway
    Dement Geriatr Cogn Disord 15:126-31. 2003
    ..Identification of mild cognitive impairment is important, since these symptoms are important for patient management and may also facilitate to determine prognosis...
  48. ncbi request reprint Subtypes of mild cognitive impairment in Parkinson's disease: progression to dementia
    Carmen Cristea Janvin
    Stavanger University Hospital, Section of Geriatric Psychiatry, Stavanger, Norway
    Mov Disord 21:1343-9. 2006
    ..However, these findings should be interpreted with caution due to the relatively small number of subjects included in this study...
  49. doi request reprint Prevalence and clinical correlates of apathy in Parkinson's disease: a community-based study
    Kenn Freddy Pedersen
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    Parkinsonism Relat Disord 15:295-9. 2009
    ....
  50. ncbi request reprint Differences in neuropathologic characteristics across the Lewy body dementia spectrum
    C Ballard
    Wolfson Centre for Age Related Diseases, Wolfson Building, Guy s Campus, King s College London, London, SE1 1UL, UK
    Neurology 67:1931-4. 2006
    ....
  51. ncbi request reprint Prevalence and correlates of disruptive behavior in patients in Norwegian nursing homes
    I Testad
    Stavanger University Hospital, Psychiatric Clinic, Stavanger, Norway
    Int J Geriatr Psychiatry 22:916-21. 2007
    ....
  52. ncbi request reprint Cognitive predictors of dementia in Parkinson's disease: a community-based, 4-year longitudinal study
    Carmen Cristea Janvin
    Department for Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway
    J Geriatr Psychiatry Neurol 18:149-54. 2005
    ..This finding may have important clinical implications as a marker of subsequent development of dementia...
  53. doi request reprint CSF amyloid-beta and tau proteins, and cognitive performance, in early and untreated Parkinson's disease: the Norwegian ParkWest study
    Guido Alves
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    J Neurol Neurosurg Psychiatry 81:1080-6. 2010
    ..The authors investigated whether AD-related CSF protein levels are altered and relate to neuropsychological performance in early, untreated PD...
  54. doi request reprint Cognitive correlates of visual hallucinations in dementia associated with Parkinson's disease
    Kolbjorn Bronnick
    Norwegian Centre for Movement Disorders, Stavanger University Hospital, Helse Stavanger, Norway
    Mov Disord 26:824-9. 2011
    ..The objective of this study was to compare the cognitive profile of hallucinating vs. nonhallucinating patients with Parkinson's disease dementia (PDD)...
  55. doi request reprint Frequency and correlates of caregiver-reported sleep disturbances in a sample of persons with early dementia
    Arvid Rongve
    Research Department, Psychiatric Clinic, Helse Fonna HF Haugesund Hospital, Haugesund, Norway
    J Am Geriatr Soc 58:480-6. 2010
    ..To identify sleep disturbances in participants with subtypes of dementia and explore clinical correlates...
  56. ncbi request reprint Are Parkinson's disease with dementia and dementia with Lewy bodies the same entity?
    Dag Aarsland
    Psychiatric Clinic, Rogaland Central Hospital, PO Box 1163, Hillevaag, 4095 Stavanger, Norway
    J Geriatr Psychiatry Neurol 17:137-45. 2004
    ....
  57. doi request reprint Disturbance of automatic auditory change detection in dementia associated with Parkinson's disease: A mismatch negativity study
    Kolbjørn S Brønnick
    Norwegian Centre for Movement Disorders, Stavanger University Hospital, P Box 8100, 4068 Helse Stavanger, Norway
    Neurobiol Aging 31:104-13. 2010
    ....
  58. doi request reprint The effect of staff training on agitation and use of restraint in nursing home residents with dementia: a single-blind, randomized controlled trial
    Ingelin Testad
    Psychiatric Clinic, Stavanger University Hospital, PO Box 8100, 4068 Stavanger, Norway
    J Clin Psychiatry 71:80-6. 2010
    ..The aim of this study was to determine whether an education and supervision intervention could reduce agitation and the use of restraints and antipsychotic drugs in nursing homes...
  59. ncbi request reprint The rate of cognitive decline in Parkinson disease
    Dag Aarsland
    Section of Geriatric Psychiatry, Central Hospital of Rogaland, Stavanger, N 4095 Hillevåg, Norway
    Arch Neurol 61:1906-11. 2004
    ....
  60. ncbi request reprint Neuropathology of dementia in Parkinson's disease: a prospective, community-based study
    Dag Aarsland
    Stavanger University Hospital, Stavanger, Norway
    Ann Neurol 58:773-6. 2005
    ..This study strongly suggests that Lewy body disease is the main substrate driving the progression of cognitive impairment in Parkinson's disease...
  61. doi request reprint APOE alleles in Parkinson disease and their relationship to cognitive decline: a population-based, longitudinal study
    Martin Wilhelm Kurz
    Department of Neurology, Stavanger University Hospital, Stavanger, Norway
    J Geriatr Psychiatry Neurol 22:166-70. 2009
    ..4%; P = .03). No significant associations between the Apolipoprotein E genotype and development and progression of dementia or time to dementia were found. More studies with larger Parkinson disease samples are warranted...
  62. doi request reprint A 12-year population-based study of psychosis in Parkinson disease
    Elin B Forsaa
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Box 8100, N 4068 Stavanger, Norway
    Arch Neurol 67:996-1001. 2010
    ..To investigate the prevalence, incidence, risk factors, and concomitants of Parkinson disease (PD)-associated psychosis (PDP) in a population-based prevalent cohort...
  63. ncbi request reprint Gray matter atrophy in Parkinson disease with dementia and dementia with Lewy bodies
    Mona K Beyer
    Department of Radiology, Stavanger University Hospital, Stavanger, Norway
    Neurology 69:747-54. 2007
    ..We conducted a study using voxel-based morphometry (VBM) to explore the pattern of cortical atrophy in DLB and PDD...
  64. ncbi request reprint The psychosocial burden on spouses of the elderly with stroke, dementia and Parkinson's disease
    Bente Thommessen
    Department of Geriatric Medicine, Ullevaal Hospital, Oslo, Norway
    Int J Geriatr Psychiatry 17:78-84. 2002
    ..66-0.69). Covariates of this factor were identified using structural equation modeling (SEM) by regression on patient's age, gender, cognitive function (MMSE), activities of daily living (ADL) and depressive symptoms (MADRS)...
  65. pmc Profile of cognitive impairment in dementia associated with Parkinson's disease compared with Alzheimer's disease
    Kolbjorn Bronnick
    Norwegian Centre for Movement Disorders, Stavanger University Hospital, Helse Stavanger, Norway
    J Neurol Neurosurg Psychiatry 78:1064-8. 2007
    ..To compare the profile of cognitive impairment in Alzheimer's disease (AD) with dementia associated with Parkinson's disease (PDD)...
  66. ncbi request reprint A systematic review of prevalence studies of dementia in Parkinson's disease
    Dag Aarsland
    Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway
    Mov Disord 20:1255-63. 2005
    ..The estimated prevalence of PDD in the general population aged 65 years and over is 0.2 to 0.5%...
  67. doi request reprint Verbal memory in drug-naive, newly diagnosed Parkinson's disease. The retrieval deficit hypothesis revisited
    Kolbjørn Brønnick
    Norwegian Centre for Movement Disorders, Stavanger University Hospital
    Neuropsychology 25:114-24. 2011
    ..This hypothesis has been challenged by new data. We have therefore investigated verbal memory and learning in a large sample of newly diagnosed, drug naïve, non-demented patients with PD...
  68. pmc Donepezil for cognitive impairment in Parkinson's disease: a randomised controlled study
    D Aarsland
    Section of Geriatric Psychiatry, Psychiatric Hospital of Rogaland, Stavanger, Norway
    J Neurol Neurosurg Psychiatry 72:708-12. 2002
    ..To study the safety and efficacy of the cholinesterase inhibitor donepezil in patients with Parkinson's disease (PD) and cognitive impairment...
  69. doi request reprint Grey matter atrophy in early versus late dementia in Parkinson's disease
    M K Beyer
    Department of Radiology, Stavanger University Hospital, Postbox 8100, 4068 Stavanger, Norway
    Parkinsonism Relat Disord 14:620-5. 2008
    ..Our results indicate that the early development of dementia in PD is associated with more severe degeneration of cortical and sub-cortical structures...
  70. ncbi request reprint Neuropsychiatric symptoms in patients with multiple sclerosis
    N Figved
    Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway
    Acta Psychiatr Scand 112:463-8. 2005
    ..To explore the range of psychiatric symptoms in patients with multiple sclerosis (MS) and their association with neurological disability...
  71. doi request reprint High prevalence of orthostatic hypotension in mild dementia
    Hogne Sonnesyn
    Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway
    Dement Geriatr Cogn Disord 28:307-13. 2009
    ..Orthostatic hypotension (OH) and QTc prolongation have potentially important prognostic and therapeutic consequences but have rarely been studied in patients with mild dementia...
  72. ncbi request reprint Visual rating of white matter hyperintensities in Parkinson's disease
    Mona K Beyer
    Department of Radiology, Stavanger University Hospital, Stavanger, Norway
    Mov Disord 21:223-9. 2006
    ..Our findings suggest that WMH in the deep white matter may contribute to dementia in PD...
  73. ncbi request reprint Disorders of motivation, sexual conduct, and sleep in Parkinson's disease
    Dag Aarsland
    Stavanger University Hospital, Psychiatric Clinic and School of Medicine, University of Bergen, Norway
    Adv Neurol 96:56-64. 2005
    ..Although some placebo-controlled trials have been published recently, no established treatments are currently available for these symptoms (85) (see Table 5-2), and thus future clinical trials are needed...
  74. doi request reprint Cortical serotonin 1A receptor levels are associated with depression in patients with dementia with Lewy bodies and Parkinson's disease dementia
    Sally I Sharp
    King s College London, Wolfson Centre for Age Related Diseases, London, UK
    Dement Geriatr Cogn Disord 26:330-8. 2008
    ..Serotonin 1A receptors (5-HT(1A)) have not been studied in dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD) patients with depression...
  75. ncbi request reprint Psychiatric and behavioral symptoms in Alzheimer's disease and other dementias: etiology and management
    Dag Aarsland
    Centre for Clinical Neuroscience Research, Stavanger University Hospital, PO Box 1163, 4095 Stavanger, Norway
    Curr Neurol Neurosci Rep 5:345-54. 2005
    ..More studies are needed to clarify the role of cholinergic and other psychotropic agents as well as nonpharmacologic interventions for psychiatric and behavioral symptoms in patients with dementia...
  76. ncbi request reprint Depressive symptom profile in Parkinson's disease: a comparison with depression in elderly patients without Parkinson's disease
    Uwe Ehrt
    Section of Geriatric Psychiatry, Stavanger University Hospital, Norway
    Int J Geriatr Psychiatry 21:252-8. 2006
    ..It is still unclear whether the disturbances of neurotransmitter activities lead to a specific profile of depressive symptoms, that is characteristic for PD and differs from that in depressed patients without PD...
  77. ncbi request reprint Pain and its relationship to depression in Parkinson disease
    Uwe Ehrt
    Research Centre for Clinical Neuroscience, Stavanger University Hospital, Psychiatric Clinic, Stavanger, Norway
    Am J Geriatr Psychiatry 17:269-75. 2009
    ..The authors examined the relationship between pain and depression in a community-based sample of patients with PD...
  78. pmc A magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel-based morphometry
    Mona K Beyer
    Department of Radiology, Stavanger University Hospital, PO Box 8100, N 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 78:254-9. 2007
    ..Dementia is common in Parkinson's disease, but the underlying brain pathology is not yet fully understood...
  79. ncbi request reprint Subthreshold depression in patients with Parkinson's disease and dementia--clinical and demographic correlates
    Uwe Ehrt
    Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway
    Int J Geriatr Psychiatry 22:980-5. 2007
    ....
  80. doi request reprint Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial
    Dag Aarsland
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, 4068 Stavanger, Norway
    Lancet Neurol 8:613-8. 2009
    ..We aimed to test the safety and efficacy of the N-methyl D-aspartate (NMDA) receptor antagonist memantine in patients with PDD or DLB...
  81. ncbi request reprint Cerebrovascular diseases and depression: epidemiology, mechanisms and treatment
    F Göthe
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Panminerva Med 54:161-70. 2012
    ..There is emerging evidence that treatment of cardiovascular disease and risk-factors can reduce the risk for late-life depression, but more studies are needed to test this hypothesis...
  82. pmc White matter hyperintensities in mild lewy body dementia
    K Oppedal
    Centre for Age Related Medicine, Stavanger University Hospital, Stavanger, Norway Department of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway
    Dement Geriatr Cogn Dis Extra 2:481-95. 2012
    ..The objective of this study was to explore the load of white matter hyperintensities (WMH) in patients with Lewy body dementia (LBD) and compare to Alzheimer's disease (AD) and normal controls (NC)...
  83. ncbi request reprint Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study
    Dag Aarsland
    Section of Geriatric Psychiatry, Psychiatric Clinic, Central Hospital of Rogaland, PO 1163, Hillevag, N 4095 Stavanger, Norway
    Arch Neurol 60:387-92. 2003
    ..Few longitudinal studies of dementia in Parkinson disease (PD) have been reported, and the proportion of patients with PD who eventually develop dementia is unknown...
  84. ncbi request reprint Changes in motor subtype and risk for incident dementia in Parkinson's disease
    Guido Alves
    The Norwegian Center for Movement Disorders, Stavanger, Norway
    Mov Disord 21:1123-30. 2006
    ..These findings raise the question whether PIGD and dementia share common or parallel neuropathology...
  85. doi request reprint Multivariate classification of patients with Alzheimer's and dementia with Lewy bodies using high-dimensional cortical thickness measurements: an MRI surface-based morphometric study
    Alexander V Lebedev
    Centre for Age Related Medicine, Stavanger University Hospital, PO Box 8100, 4068 Stavanger, Norway
    J Neurol 260:1104-15. 2013
    ..Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the most common neurodegenerative dementia types. It is important to differentiate between them because of the differences in prognosis and treatment approaches...
  86. ncbi request reprint The effect of staff training on the use of restraint in dementia: a single-blind randomised controlled trial
    I Testad
    Stavanger University Hospital, Psychiatric Clinic, Stavanger Norway
    Int J Geriatr Psychiatry 20:587-90. 2005
    ..Use of restraint amongst institutionalised elderly with dementia and problem behaviour not only remains widespread, but also appears to be accepted as inevitable...
  87. ncbi request reprint Validation of the Unified Parkinson's Disease Rating Scale (UPDRS) section I as a screening and diagnostic instrument for apathy in patients with Parkinson's disease
    Kenn Freddy Pedersen
    The Norwegian Centre for Movement Disorders, Stavanger, Norway
    Parkinsonism Relat Disord 14:183-6. 2008
    ..A score of 2 or more on the motivation/initiative item was adequate to screen for apathy, whereas a score of 4 had high diagnostic accuracy at the cost of unacceptable low sensitivity...
  88. ncbi request reprint Role of cholinesterase inhibitors in Parkinson's disease and dementia with Lewy bodies
    Dag Aarsland
    Rogaland Central Hospital, Psychiatric Clinic, PO Box 1163, Hillevaag, 4095 Stavanger, Norway
    J Geriatr Psychiatry Neurol 17:164-71. 2004
    ....
  89. doi request reprint CSF amyloid β38 as a novel diagnostic marker for dementia with Lewy bodies
    Ezra Mulugeta
    Department of Old Age Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Stavanger, Norway
    J Neurol Neurosurg Psychiatry 82:160-4. 2011
    ..Although CSF markers such as amyloid β42 (Aβ42) and P-tau can distinguish between AD and normal controls, their ability to distinguish between AD and DLB is not adequate...
  90. ncbi request reprint Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, England
    Arch Neurol 61:919-25. 2004
    ..Dementia with Lewy bodies (DLB) is a common form of late-life dementia that can be difficult to differentiate from other disorders, especially Alzheimer disease (AD), during life. At autopsy the striatal dopaminergic transporter is reduced...
  91. ncbi request reprint Pentagon drawing and neuropsychological performance in Dementia with Lewy Bodies, Alzheimer's disease, Parkinson's disease and Parkinson's disease with dementia
    Francesca Cormack
    Psychology Department, The Henry Wellcome Building For Neuroecology, Framlington Place, Newcastle University, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 19:371-7. 2004
    ..There have been suggestions that constructional apraxia is prevalent in DLB, and may provide a sensitive marker of the disease...
  92. ncbi request reprint Dementia with Lewy bodies
    Ian McKeith
    Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK
    Lancet Neurol 3:19-28. 2004
    ..Clear guidance on the management of DLB is urgently needed. Virtually unrecognised 20 years ago, DLB could within this decade be one of the most treatable neurodegenerative disorders of late life...
  93. ncbi request reprint FMR1 alleles in Parkinson's disease: relation to cognitive decline and hallucinations, a longitudinal study
    Martin Wilhelm Kurz
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    J Geriatr Psychiatry Neurol 20:89-92. 2007
    ..However, the marked cognitive decline in 2 patients carrying intermediate-size alleles points to a possible association. More studies with larger PD samples are warranted...
  94. ncbi request reprint Diagnostic criteria for psychosis in Parkinson's disease: report of an NINDS, NIMH work group
    Bernard Ravina
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14620, USA
    Mov Disord 22:1061-8. 2007
    ..These criteria require validation and may be refined, but form a starting point for studies of the epidemiology and pathophysiology of PDPsy, and are a potential indication for therapy development...
  95. doi request reprint Neuropsychiatric correlates of cerebrospinal fluid biomarkers in Alzheimer's disease
    Ragnhild Skogseth
    Institute of Clinical Medicine, School of Medicine, University of Bergen, Bergen, Norway
    Dement Geriatr Cogn Disord 25:559-63. 2008
    ..Psychosis, agitation, apathy and depression were assessed using standardised measures in 32 patients with mild Alzheimer's disease...
  96. ncbi request reprint Clinical diagnostic criteria for dementia associated with Parkinson's disease
    Murat Emre
    Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Mov Disord 22:1689-707; quiz 1837. 2007
    ..Based on the characteristic features associated with this condition, clinical diagnostic criteria for probable and possible PD-D are proposed...
  97. ncbi request reprint Effects of rivastigmine in patients with and without visual hallucinations in dementia associated with Parkinson's disease
    David Burn
    Regional Neuroscience Center, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Mov Disord 21:1899-907. 2006
    ..Visual hallucinations appear to predict more rapid decline and possibly greater therapeutic benefit from rivastigmine treatment in PDD...
  98. ncbi request reprint Management of Parkinson's disease dementia : practical considerations
    Arvid Rongve
    Haugesund County Hospital, Haugesund, Norway University of Bergen, Bergen, Norway
    Drugs Aging 23:807-22. 2006
    ..Non-pharmacological interventions can also be effective but require further study...
  99. ncbi request reprint Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community-based, longitudinal study
    Martin Wilhelm Kurz
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Mov Disord 21:2170-4. 2006
    ..Further studies with larger samples are needed to explore a possible relationship between a family history of PD and development of dementia in PD and its potential pathogenetic mechanisms...
  100. ncbi request reprint A multinational, randomised, 12-week study comparing the effects of donepezil and galantamine in patients with mild to moderate Alzheimer's disease
    Roy W Jones
    Research Institute for the Care of the Elderly, St Martin s Hospital, Bath, UK
    Int J Geriatr Psychiatry 19:58-67. 2004
    ....
  101. ncbi request reprint Familial occurrence of dementia and parkinsonism: a systematic review
    Martin Wilhelm Kurz
    Department of Neurology, Heinrich Heine University Dusseldorf, Germany
    Dement Geriatr Cogn Disord 22:288-95. 2006
    ..There is a convincing genetic overlap between both syndromes, suggesting that they share a common etiological factor...