proglumide

Summary

Summary: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.

Top Publications

  1. ncbi Proglumide attenuates experimental colitis in rats
    Ahmed Al Moutaery
    Department of Pathology, Armed Forces Hospital, Riyadh 11159, Saudi Arabia
    Exp Toxicol Pathol 56:327-32. 2005
  2. ncbi Cholecystokinin octapeptide increases spontaneous glutamatergic synaptic transmission to neurons of the nucleus tractus solitarius centralis
    V Baptista
    Department of Neuroscience, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    J Neurophysiol 94:2763-71. 2005
  3. ncbi Circulating ethanol does not stimulate pancreatic secretion in conscious rats
    Wei Jin
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
    Pancreas 27:e90-5. 2003
  4. ncbi Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake
    Chun Min Lo
    Dept of Pathology and Laboratory Medicine, Univ of Cincinnati, 2120 E Galbraith Rd, Cincinnati, OH 45237 0507, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1490-4. 2007
  5. ncbi The inhibitory effect of proglumide on meal-induced insulin sensitization in rats
    Barna Peitl
    Department of Pharmacology and Pharmacotherapy, University of Debrecen, H 4032, Debrecen, Hungary
    Metabolism 56:863-4. 2007
  6. ncbi Enterostatin inhibition of dietary fat intake is dependent on CCK-A receptors
    Ling Lin
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Physiol Regul Integr Comp Physiol 285:R321-8. 2003
  7. ncbi Vagally mediated, nonparacrine effects of cholecystokinin-8s on rat pancreatic exocrine secretion
    Eddy Viard
    Department of Neuroscience, Pennington Biomedical Research Center Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Gastrointest Liver Physiol 293:G493-500. 2007
  8. ncbi Inhibitory effect of loxiglumide (CR 1505), a cholecystokinin receptor antagonist, on N-nitrosobis(2-oxopropyl) amine-induced biliary carcinogenesis in Syrian hamsters
    Yoshifumi Ogura
    Department of Surgery, Matsusaka City Hospital, 2158 5 Myojin, Hisai City 514 1101, Japan
    World J Surg 26:359-65. 2002
  9. ncbi CCK1 antagonists: are they ready for clinical use?
    Shajan A S Peter
    Department of Gastroenterology, University Hospital, Basel, Switzerland
    Dig Dis 24:70-82. 2006
  10. ncbi The effect of luminal ghrelin on pancreatic enzyme secretion in the rat
    Katarzyna Nawrot Porabka
    Department of Medical Physiology, Faculty of Health Care, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31 531 Cracow, Poland
    Regul Pept 143:56-63. 2007

Research Grants

  1. MINIMAL ENTERAL NUTRIENT REQUIREMENTS IN NEONATES
    Douglas Burrin; Fiscal Year: 1999
  2. 5-HT3 receptor mediation of 5-HT & CCK-induced satiation
    Matthew Hayes; Fiscal Year: 2005
  3. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2007
  4. Distributed neural control of energy expenditure
    Matthew Hayes; Fiscal Year: 2007
  5. BOLD Prediction of Success in a Weight Loss Program
    James Cox; Fiscal Year: 2007
  6. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
  7. OPIOID-BENZODIAZEPINE INTERACTIONS
    Igor Kissin; Fiscal Year: 1993
  8. Role of NTS POMC neurons in energy homeostasis
    SUZANNE APPLEYARD; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications108 found, 100 shown here

  1. ncbi Proglumide attenuates experimental colitis in rats
    Ahmed Al Moutaery
    Department of Pathology, Armed Forces Hospital, Riyadh 11159, Saudi Arabia
    Exp Toxicol Pathol 56:327-32. 2005
    ..In the present study, an attempt was made to study the effect of proglumide, a CCK receptor antagonist on experimental colitis in rats...
  2. ncbi Cholecystokinin octapeptide increases spontaneous glutamatergic synaptic transmission to neurons of the nucleus tractus solitarius centralis
    V Baptista
    Department of Neuroscience, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    J Neurophysiol 94:2763-71. 2005
    ....
  3. ncbi Circulating ethanol does not stimulate pancreatic secretion in conscious rats
    Wei Jin
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
    Pancreas 27:e90-5. 2003
    ..We conclude that circulating ethanol does not stimulate pancreatic secretion in awake, recovered rats and that intraduodenal ethanol-stimulated pancreatic secretion is mediated by CCK...
  4. ncbi Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake
    Chun Min Lo
    Dept of Pathology and Laboratory Medicine, Univ of Cincinnati, 2120 E Galbraith Rd, Cincinnati, OH 45237 0507, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1490-4. 2007
    ....
  5. ncbi The inhibitory effect of proglumide on meal-induced insulin sensitization in rats
    Barna Peitl
    Department of Pharmacology and Pharmacotherapy, University of Debrecen, H 4032, Debrecen, Hungary
    Metabolism 56:863-4. 2007
    ..Single intravenous doses of proglumide, a cholecystokinin-1 receptor antagonist, decreased insulin sensitivity in fed animals in a dose-dependent ..
  6. ncbi Enterostatin inhibition of dietary fat intake is dependent on CCK-A receptors
    Ling Lin
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Physiol Regul Integr Comp Physiol 285:R321-8. 2003
    ..The data suggest that both the peripheral and central responses to enterostatin are mediated through or dependent on peripheral and central CCK-A receptors...
  7. ncbi Vagally mediated, nonparacrine effects of cholecystokinin-8s on rat pancreatic exocrine secretion
    Eddy Viard
    Department of Neuroscience, Pennington Biomedical Research Center Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Gastrointest Liver Physiol 293:G493-500. 2007
    ..Our data suggest that the CCK-8s-induced increases in PES are due mainly to a paracrine effect of CCK; however, a relevant portion of the effects of CCK is due also to an effect of the peptide on brain stem vagal circuits...
  8. ncbi Inhibitory effect of loxiglumide (CR 1505), a cholecystokinin receptor antagonist, on N-nitrosobis(2-oxopropyl) amine-induced biliary carcinogenesis in Syrian hamsters
    Yoshifumi Ogura
    Department of Surgery, Matsusaka City Hospital, 2158 5 Myojin, Hisai City 514 1101, Japan
    World J Surg 26:359-65. 2002
    ..A difference between carcinogenesis in the intrahepatic bile ducts and extrahepatic biliary tract may be another reason...
  9. ncbi CCK1 antagonists: are they ready for clinical use?
    Shajan A S Peter
    Department of Gastroenterology, University Hospital, Basel, Switzerland
    Dig Dis 24:70-82. 2006
    ....
  10. ncbi The effect of luminal ghrelin on pancreatic enzyme secretion in the rat
    Katarzyna Nawrot Porabka
    Department of Medical Physiology, Faculty of Health Care, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31 531 Cracow, Poland
    Regul Pept 143:56-63. 2007
    ..Activation of vagal reflexes and CCK release as well as central mechanisms could be implicated in the stimulatory effect of luminal ghrelin on the pancreatic exocrine functions...
  11. ncbi Cholecystokinin reduces ethanol consumption in golden hamsters
    David Dibattista
    Brock University, Department of Psychology, St Catharines, Ontario, Canada L2S 3A1
    Alcohol 29:173-81. 2003
    ..Findings are consistent with the notion that endogenous CCK plays a key role in the short-term control of ethanol intake in hamsters...
  12. ncbi Role of leptin in the control of feeding of goldfish Carassius auratus: interactions with cholecystokinin, neuropeptide Y and orexin A, and modulation by fasting
    Helene Volkoff
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Brain Res 972:90-109. 2003
    ..The CCK receptor antagonist proglumide blocked both central and peripheral CCK satiety effects...
  13. ncbi Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan
    Keiko Shiratori
    Department of Gastroenterology, Tokyo Women s Medical University, Tokyo, Japan
    Pancreas 25:e1-5. 2002
    ..CCK appears to play an important role in the development and progression of acute pancreatitis, and the recent development of CCK antagonists has provided a new approach to the treatment of acute pancreatitis in humans...
  14. ncbi Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats
    Chiu Lung Wu
    Department of Physiology, School of Medicine, National Yang Ming University, Shih Pai, Taipei 11221, Taiwan, Republic of China
    Naunyn Schmiedebergs Arch Pharmacol 367:406-13. 2003
    ..These results suggest that OT inhibits gastric emptying and gastrointestinal transit in female rats via a mechanism involving CCK stimulation and CCK(1) receptor activation...
  15. ncbi Effect of cholecystokinin-A receptor blockade on postprandial insulinaemia and gastric emptying in humans
    L Hidalgo
    Department of Surgery, Hospital de Mataro, Mataro, Spain
    Neurogastroenterol Motil 14:519-25. 2002
    ..Inhibition of pancreatic polypeptide release may reflect an independent effect of loxiglumide on vagal control involved in pancreatic polypeptide release...
  16. ncbi Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by estradiol in ovariectomized rats
    C L Wu
    Dept of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC
    Scand J Gastroenterol 37:1133-9. 2002
    ..CONCLUSIONS: The results suggest that EB inhibits gastric emptying and gastrointestinal transit in ovariectomized rats via a mechanism involving CCK stimulation and CCK(A) receptor activation...
  17. ncbi Anxiogenic effect of cholecystokinin in the dorsal periaqueductal gray
    Cristina Ferreira Netto
    Laboratory of Psychobiology, FFCLRP, , SP, Brazil
    Neuropsychopharmacology 29:101-7. 2004
    ..This effect was also prevented by pretreatment with PD 135,158. These results suggest that CCK-8s, acting on CCK-2 receptors, may modulate anxiety reactions in the dPAG...
  18. ncbi Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans
    C Beglinger
    Department of Research, Division of Gastroenterology, University Hospital, CH-4031 Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 280:R1149-54. 2001
    ..Repeated-dose studies comparing hunger and satiety responses after CCK-A receptor blockade in healthy subjects and patients with eating disorders may help clarify the possible involvement of endogenous CCK in these conditions...
  19. ncbi Involvement of capsaicin-sensitive afferent nerves and cholecystokinin 2/gastrin receptors in gastroprotection and adaptation of gastric mucosa to Helicobacter pylori-lipopolysaccharide
    Tomasz Brzozowski
    Department of Physiology, Jagiellonian University School of Medicine, Cracow, Poland
    J Pharmacol Exp Ther 310:116-25. 2004
    ....
  20. ncbi Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity
    Karine Proulx
    Genome Research Institute, ML 0506, University of Cincinnati, 2170 E Galbraith Road, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 289:R729-37. 2005
    ..Despite that OEA-induced anorexia is unlikely to be due to impaired motor activity, our data raise a cautionary note in how specific behavioral and metabolic effects of OEA should be interpreted...
  21. ncbi Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioids
    Suzanne M Appleyard
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 25:3578-85. 2005
    ..These findings identify a potential satiety pathway in which visceral afferents directly activate NTS POMC-EGFP neurons with excitatory inputs that are appropriately modulated by appetite regulators...
  22. ncbi Effects of juice from Morinda citrifolia (Noni) on gastric emptying in male rats
    Hsiao-Fung Pu
    Department of Physiology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan, Republic of China
    Chin J Physiol 47:169-74. 2004
    ..These results suggest that oral noni inhibits gastric emptying in male rats via a mechanism involving stimulation of CCK secretion and CCK1 receptor activation...
  23. ncbi Role of cholecystokinin in appetite control and body weight regulation
    T J Little
    University of Adelaide Department of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Obes Rev 6:297-306. 2005
    ..Hence, it appears unlikely that manipulating the pathways by which CCK modulates energy intake will prove to be an effective strategy in the long term management of obesity...
  24. ncbi Estrogen and CCK1 receptor modification of mu-opioid receptor binding in the cortex of female rats
    Arnulfo Quesada
    Department of Neurobiology, Laboratory of Neuroendocrinology of the Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    Brain Res 1073:316-20. 2006
    ..These results demonstrate an estrogen regulation of the MOP receptor and a protein-protein interaction between CCK1 receptor and MOP receptor...
  25. ncbi Pharmacological study of IQM-97,423, a potent and selective CCK1 receptor antagonist with protective effect in experimental acute pancreatitis
    M Latorre
    Department of Pharmacology, University of Navarra, Pamplona, Spain
    Pharmacology 72:68-76. 2004
    ..Consequently, the pyridopyrimidine derivative IQM-97,423 is a potent and highly selective CCK1 receptor antagonist with preventive effects in two experimental models of acute pancreatitis and a potential therapeutic interest...
  26. ncbi Peripheral participation of cholecystokinin in the morphine-induced peripheral antinociceptive effect in non-diabetic and diabetic rats
    Jorge E Torres-López
    Laboratorio Mecanismos del Dolor, Centro de Investigación y Posgrado, División Académica de Ciencias de la Salud, Universidad Juarez Autonoma de Tabasco, Villahermosa, Tabasco, Mexico
    Neuropharmacology 52:788-95. 2007
    The effects of cholecystokinin (CCK-8) and the CCK receptor antagonist proglumide, on antinociception induced by local peripheral (subcutaneous) injected morphine in non-diabetic (ND) and streptozotocin-induced diabetic (D) rats, were ..
  27. ncbi Cholecystokinin-induced satiety is mediated through interdependent cooperation of CCK-A and 5-HT3 receptors
    Matthew R Hayes
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, 126 South Henderson, University Park, PA 16802 6504, USA
    Physiol Behav 82:663-9. 2004
    ..Most likely, this interconnection exists through a feed-forward parallel model arising from CCK-A and 5-HT3 receptors, where activation of one system engages the other to intensify the overall satiety signal...
  28. ncbi The effects of an essential fatty acid compound and a cholecystokinin-8 antagonist on iron deficiency induced anorexia and learning deficits
    Shlomo Yehuda
    Psychopharmacology Laboratory, Department of Psychology and Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 52900, Israel
    Nutr Neurosci 7:85-90. 2004
    ..Treatment with a fatty acid compound blocked both the learning deficits and the anorexia, while a CCK-8 antagonist was successful only against the anorectic effects...
  29. ncbi The effect of cholecystokinin peptides on ovine duodeno-jejunal slow waves with and without pretreatment with proglumide
    K W Romanski
    Department of Animal Physiology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
    J S Afr Vet Assoc 78:209-14. 2007
    ..In the course of additional experiments, saline and hormone administration was directly preceded by infusion of proglumide, an unspecific CCK receptor antagonist, at a dose of 10 mg/kg...
  30. ncbi Long-term bile diversion enhances basal and duodenal oleate-stimulated pancreatic exocrine secretion in dogs
    Michinaga Takahashi
    South Miyagi Medical Center, Ohgawara 989 1253
    Tohoku J Exp Med 203:87-95. 2004
    ..Long-term bile diversion enhances basal and oleate-stimulated pancreatic exocrine secretion, at least partly via increased cholecystokinin secretion...
  31. ncbi Suppression of food intake by GI fatty acid infusions: roles of celiac vagal afferents and cholecystokinin
    James E Cox
    Department of Psychology, 415 Campbell Hall, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Physiol Behav 82:27-33. 2004
    ....
  32. ncbi Effects of the cholecystokinin A receptor antagonist loxiglumide on the proliferation and cell cycle time of pancreatic acinar cells in rats
    Daisuke Kanemitsu
    Graduate School of Medical Science, Molecular Gastroenterology, and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Pancreas 32:190-6. 2006
    ....
  33. ncbi Analysis of strain difference in behavior to Cholecystokinin (CCK) receptor mediated drugs in PVG hooded and Sprague-Dawley rats using elevated plus-maze test apparatus
    J M Farook
    Department of Pharmacology, Faculty of Medicine, National University of Singapore, 18 Medical Drive, Kent Ridge Cresent, 17597 Singapore, Singapore
    Neurosci Lett 358:215-9. 2004
    ....
  34. ncbi Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin
    Galina Burdyga
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    J Neurosci 24:2708-15. 2004
    ..Because CCK is a satiety factor that acts via the vagus nerve and CB1 agonists stimulate food intake, the data suggest a new mechanism modulating the effect on food intake of satiety signals from the gastrointestinal tract...
  35. ncbi The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, 10125 Turin, Italy
    J Neurosci 26:12014-22. 2006
    ..The administration of the mixed cholecystokinin (CCK) type-A/B receptor antagonist proglumide blocked nocebo hyperalgesia completely but had no effect on HPA hyperactivity, which suggests a specific ..
  36. ncbi Cholecystokinin inhibits evoked inhibitory postsynaptic currents in the rat nucleus accumbens indirectly through gamma-aminobutyric acid and gamma-aminobutyric acid type B receptors
    Samuel B Kombian
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Safat, Kuwait
    J Neurosci Res 79:412-20. 2005
    ..8% +/- 1.6% (n=6). This CCK-induced IPSC depression was blocked by pretreatment with proglumide (100 microM; -3.7% +/- 6.9%; n=4) and by LY225910 (100 nM), a selective CCKB receptor antagonist (4.4% +/- 2...
  37. ncbi Cholecystokinin octapeptide improves cardiac function by activating cholecystokinin octapeptide receptor in endotoxic shock rats
    Xiao Yun Zhao
    The First Affiliated Hospital of Shantou University Medical College, Shantou 515031, Guangdong Province, China
    World J Gastroenterol 11:3405-10. 2005
    ..To explore the effect of sulfated cholecystokinin octapeptide (sCCK-8) on cardiac functions and its receptor mechanism in endotoxic shock (ES) rats...
  38. ncbi Autocrine stimulation of growth of AR4-2J rat pancreatic tumour cells by gastrin
    M Blackmore
    Gastrointestinal Drug Delivery Research Centre, University of Newcastle upon Tyne, Medical School, UK
    Br J Cancer 66:32-8. 1992
    ..The concentration required for 50% inhibition (IC50) of cell growth by the amino acid-derived antagonists proglumide (3.5 x 10(-3) M), benzotript (1.8 x 10(-3) M), loxiglumide (1.1 x 10(-4) M) and lorglumide (6...
  39. ncbi Prevention of recurrent ulcer bleeding, a multicentre study of the effect of ranitidine and trimipramine over one year
    R Stave
    Department of Medicine, Ulleval University Hospital, Oslo, Norway
    Scand J Gastroenterol Suppl 124:55-62. 1986
    ..An uncontrolled study has been performed using proglumide (27), a controlled study with vasopressin (28) and with secretin versus somatostatin (28)...
  40. ncbi Gastric antisecretory drugs induce leukocyte-endothelial cell interactions through gastrin release and activation of CCK-2 receptors
    Angeles Alvarez
    Centro de Investigación Biomédica en Red Enfermedades Hépaticas y Digestivas, Facultad de Medicina, Universidad de Valencia, Avd Blasco Ibáñez 15, 46010 Valencia, Spain
    J Pharmacol Exp Ther 323:406-13. 2007
    ..Pretreatment with the CCK-2 receptor antagonist proglumide prevented these inflammatory events in all cases...
  41. ncbi Effect of cholecystokinin octapeptide on tumor necrosis factor alpha transcription and nuclear factor-kappaB activity induced by lipopolysaccharide in rat pulmonary interstitial macrophages
    Bin Cong
    Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China
    World J Gastroenterol 8:718-23. 2002
    ....
  42. ncbi Cholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats
    Josimari M Desantana
    Department of Physical Therapy, Federal University of Sergipe, Av Marechal Rondon, S N, Jardim Rosa Elze, Sao Cristovao, Sergipe CEP 49100 000, Aracaju, Brazil
    Pain 148:84-93. 2010
    ..Animals treated systemically, prior to TENS, with the CCK antagonist, proglumide, did not develop tolerance to repeated application of TENS on the fourth day...
  43. ncbi Opioidergic effects of nonopioid analgesics on the central nervous system
    Horacio Vanegas
    Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Cell Mol Neurobiol 22:655-61. 2002
    ..Dipyrone tolerance can be reverted by proglumide, a cholecystokinin antagonist. 3...
  44. ncbi Involvement of cholecystokinin in baseline and post-prandial whole body insulin sensitivity in rats
    Barna Peitl
    Dept Pharmacology and Pharmacotherapy, University of Debrecen, H 4032 Debrecen, Nagyerdei blvd 98, Hungary
    Eur J Pharmacol 644:251-6. 2010
    ..The involvement of CCK in post-prandial insulin sensitization was assessed by using proglumide, a CCK receptor blocker, by assessment of hypothalamic CCK-1/CCK-2 receptor expression by rt-PCR technique and ..
  45. ncbi Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats
    Yohji Fukazawa
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, Wakayama 641 8509, Japan
    J Pharmacol Sci 104:159-66. 2007
    ..The attenuation of morphine analgesia following EA was reversed by i.t. proglumide, a CCK-receptor antagonist (0.01 microg)...
  46. ncbi Effects of cholecystokinin octapeptide on rat cardiac function and the receptor mechanism
    Xiao Yun Zhao
    Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China
    Sheng Li Xue Bao 54:239-43. 2002
    ..v.) elicited a bradycardia and marked increase in MAP, LVP and LV dp/dtmax (P<0.01). (2) Proglumide (1.0 mg/kg i.v...
  47. ncbi Effect of cholecystokinin octapeptide on diacylglycerol-PKC signaling pathway in rat pulmonary interstitial macrophages stimulated by lipopolysaccharide
    Shun-Jiang Xu
    Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China
    Acta Pharmacol Sin 26:1497-504. 2005
    ..01). This inhibitory effect of CCK-8 could be abrogated partly by proglumide (non-selective CCK receptor antagonist), CR-1409 (selective CCK-A receptor antagonist), and CR-2945 (selective ..
  48. ncbi Gastric leptin: a novel role in cardiovascular regulation
    D M Sartor
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    Am J Physiol Heart Circ Physiol 298:H406-14. 2010
    ....
  49. ncbi The effects on diet, anastomotic type, and loxiglumide on gastric emptying following gastrojejunostomy
    Tayfun Yucel
    Taksim Training and Research Hospital, Istanbul, Turkey
    Int J Surg 7:163-7. 2009
    ....
  50. ncbi Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK(1) receptor
    Yuko Yamada
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Peptides 31:909-14. 2010
    ..These results suggest that the anti-hypertensive activity of rapakinin might be mediated mainly by the PGI(2)-IP receptor, followed by CCK-CCK(1) receptor-dependent vasorelaxation...
  51. ncbi Anti-inflammatory action of cholecystokinin and melatonin in the rat parotid gland
    H Cevik-Aras
    Division of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Goteborg, Sweden
    Oral Dis 16:661-7. 2010
    ..To define the influence of cholecystokinin and melatonin on the inflammatory response of the lipopolysaccharide-exposed rat parotid gland...
  52. ncbi Effects of amylin on feeding of goldfish: interactions with CCK
    Rajiv Thavanathan
    Department of Biology, Memorial University of Newfoundland, St. John's, NL, Canada A1B 3X9
    Regul Pept 133:90-6. 2006
    ..c.v. injections of proglumide, a CCK receptor antagonist, on the central effects of AMY. AMY injected i.p...
  53. ncbi Additive effects of cannabinoid CB1 receptors blockade and cholecystokinin on feeding inhibition
    L Orio
    Departamento de Psicobiología Facultad de Psicología Universidad Complutense, Madrid 28223, Spain
    Pharmacol Biochem Behav 98:220-6. 2011
    ..In conclusion, these results report additive anorectic actions for CCK1 activation and peripheral CB1 receptor blockade providing a framework for combined therapies in the treatment of eating disorders...
  54. ncbi Stimulatory effect of N-methyltyramine, a congener of beer, on pancreatic secretion in conscious rats
    Eri Tsutsumi
    Research Center, Suntory Limited, 1 1 1 Wakayamadai, Shimamoto cho, Mishima gun, Osaka 618 8503, Japan
    Alcohol Clin Exp Res 34:S14-7. 2010
    ..N-methyltyramine (NMT) was isolated from beer as a factor in stimulating gastric acid secretion. In this study, we examined NMT to determine whether the congener stimulated pancreatic secretion in conscious rats...
  55. ncbi Localization of CCK-1R in the omasum and role of CCK in the regulation of omasal contractions in sheep
    Takenori Onaga
    Laboratory of Veterinary Physiology, Department of Biosciences, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai Midorimachi, Ebetsu, Hokkaido, Japan
    Domest Anim Endocrinol 35:231-44. 2008
    ....
  56. ncbi [Receptor mechanisms underlying the modulation of lipopolysaccharide-induced nuclear factor-kappaB expression in vascular endothelial cells by cholecystokinin octapeptide]
    Feng Gao
    Department of Forensic Medicine and Pathophysiology, Shijiazhuang 050017, Hebei, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 18:150-3. 2006
    ....
  57. ncbi Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption
    Chun Min Lo
    Department of Pathology, University of Cincinnati, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 292:R268-73. 2007
    ..We conclude that the formation and/or secretion of chylomicron are critical steps for initiating neuronal activation in the brain...
  58. ncbi Naloxone, not proglumide or MK-801, alters effects of morphine preexposure on morphine-induced taste aversions
    Meredith A Fox
    Laboratory of Clinical Science, Building 10, Room 3D41 National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Pharmacol Biochem Behav 84:169-77. 2006
    ..The present experiments were performed to assess the ability of the CCK antagonist proglumide and the NMDA antagonist MK-801 to affect tolerance to the aversive properties of morphine as indexed by ..
  59. ncbi Effect of intravenous infusion of proglumide on ruminal motility in conscious sheep (Ovis aries)
    T Onaga
    Laboratory of Veterinary Physiology, Department of Biosciences, School of Veterinary Medicine, Rakuno Gakuen University, Japan
    Vet Res Commun 31:1021-36. 2007
    The effects of intravenous infusion of proglumide on regular ruminal contractions were examined in conscious sheep using doses that inhibit pancreatic exocrine secretion...
  60. ncbi Cholecystokinin-8s excites identified rat pancreatic-projecting vagal motoneurons
    Shuxia Wan
    Department of Neuroscience, Pennington Biomedical Research Center Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Gastrointest Liver Physiol 293:G484-92. 2007
    ..These data indicate that CCK-8s may control pancreas-exocrine secretion also via an effect on pancreas-projecting DMV neurons...
  61. ncbi Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes"
    Stefania De Luca
    Interuniversity Research Center on Bioactive Peptides (CIRPeB, University of Naples Federico II, and Institute of Biostructures and Bioimaging of CNR, Via Mezzocannone, 16 I-80134 Naples, Italy
    J Med Chem 49:2456-62. 2006
    ..Conformational studies, using NMR and energy minimization procedures, have allowed formulation of a new hypothesis on the CCK(1)-R binding mode of the anthranilic antagonists...
  62. ncbi Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitary
    Hyun Joon Kim
    Division of Clinical and Reproductive Sciences, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    J Endocrinol 195:393-405. 2007
    ..Taken together, this study finds CCK-AR to be an ERalpha downstream gene in the pituitary and suggests that CCK-AR may play a role in the estrogen sensitization of the pituitary response to GnRH...
  63. ncbi Parasympathetic non-adrenergic, non-cholinergic transmission in rat parotid glands: effects of cholecystokinin-A and -B receptor antagonists on the secretory response
    J Ekstrom
    Section of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, Medicinaregatan 15 D, 413 90, Goteborg, Sweden
    Regul Pept 146:278-84. 2008
    ..Thus, under physiological conditions, the cholecystokinin receptors of the parotid gland are likely to be stimulated by circulating hormones rather than by nervous activity...
  64. ncbi Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats
    Chiu Lung Wu
    Department of Basic Medical Science, Hung Kuang University, Taiwan, ROC
    Eur J Pharmacol 580:407-15. 2008
    ..These results suggest that oxytocin inhibits gastric emptying and gastrointestinal transit in ovariectomized rats via a mechanism involving the stimulation of CCK release and CCK1 receptor activation...
  65. ncbi Involvement of vagal nerves in the pancreatostimulatory effects of luminal melatonin, or its precursor L-tryptophan. Study in the rats
    K Nawrot-Porabka
    Department of Med Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, 16 Grzegorzecka Street, Krakow, Poland
    J Physiol Pharmacol 58:81-95. 2007
    ..Melatonin receptors have been detected on pancreatic beta cells and this indoloamine influences the endocrine pancreatic function but the role of melatonin on pancreatic exocrine secretion is not known...
  66. ncbi The endogenous CCK mediation of electroacupuncture stimulation-induced satiety in rats
    Sun Kwang Kim
    Department of East West Medicine, Graduate School, Kyung Hee University, Seoul 130 701, Republic of Korea
    Peptides 29:564-70. 2008
    ..Subdiaphragmatic vagotomy also blocked the satiety effect of ST36 EA stimulation in Sprague-Dawley rats. These results suggest that ST36 EA stimulation elicits satiety in rats and this is mediated by the endogenous CCK signaling pathway...
  67. ncbi Involvement of cholecystokinin in peripheral nociceptive sensitization during diabetes in rats as revealed by the formalin response
    Isela E Juárez-Rojop
    Laboratorio Mecanismos del Dolor, Centro de Investigación y Posgrado, División Académica de Ciencias de la Salud, Universidad Juarez Autonoma de Tabasco, Villahermosa, Tabasco, Mexico
    Pain 122:118-25. 2006
    ..In addition, local peripheral administration of the non-selective CCK receptor antagonist proglumide (1-100 microg), CCK(A) receptor antagonist lorglumide (0.1-100 microg) or CCK(B) receptor antagonist CR-2945 (0...
  68. ncbi Responses of human sling and clasp fibers to cholecystokinin (CCK) and gastrin through CCK receptors
    Jun Feng Liu
    Department of Thoracic Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, China
    J Gastroenterol Hepatol 23:1608-12. 2008
    ..This research was conducted to look at the responses of the sling and clasp fibers forming the human lower esophageal sphincter (LES) to CCK and gastrin, and the role of CCK receptors in the responses...
  69. ncbi Cholecystokinin1 receptors mediate the increase in Fos-like immunoreactivity in the rat myenteric plexus following intestinal oleate infusion
    Stephen Gulley
    Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, AL 36088, USA
    Physiol Behav 86:128-35. 2005
    ..However, failure of lorglumide to attenuate the increase of Fos-LI in the ileal submucosal plexus following intestinal glucose suggests that some intestinal nutrients trigger Fos-LI induction via CCK(1) receptor-independent pathways...
  70. ncbi Synthesis, molecular modeling and QSAR studies in chiral 2,3-disubstituted-1,2,3,4-tetrahydro-9H-pyrido(3,4-b)indoles as potential modulators of opioid antinociception
    A K Saxena
    Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India
    Bioorg Med Chem 9:1559-70. 2001
    ..these compounds, 3e, 3g, 3h, 4a, 4b and 4h, exhibited antinociceptive potentiation comparable to benzotript and proglumide. In order to identify the essential chemical structural features important for this potentiation, molecular ..
  71. ncbi Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake
    J I Fratucci De Gobbi
    Department of Physiology and Pathology, School of Dentistry, Paulista State University (UNESP, 14801 - 903 Araraquara, , Brazil
    Am J Physiol Regul Integr Comp Physiol 280:R1301-7. 2001
    ..Bilateral LPBN injections of high doses of the 5-HT antagonist methysergide (4 microg) or the CCK antagonist proglumide (50 microg), alone or combined, produced similar increases in water and 1.8% NaCl intake...
  72. ncbi Role of cholecystokinin in the intestinal phase of pancreatic circulation in dogs
    M Nakajima
    Internal Medicine II, Nagoya University School of Medicine, Nagoya 466-8550, Japan
    Am J Physiol Gastrointest Liver Physiol 280:G614-20. 2001
    ..CCK is a potent and specific pancreatic vasodilator, with its effect mediated by CCK-A receptors. CCK plays an important role in the regulation of the intestinal phase of the pancreatic circulation in dogs...
  73. ncbi Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems
    I Kissin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Anesth Analg 91:110-6. 2000
    ..CCK(B) receptor antagonists (proglumide, CI-988, and L-365,260) and NMDA-NO cascade inhibitors (dizocilpine and NO synthase inhibitor) were administered ..
  74. ncbi The role of brain-gut peptides in the control of sodium appetite
    G L Edwards
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602, USA
    Ann N Y Acad Sci 897:192-7. 1999
    ..Finally, intraperitoneal administration of the CCK receptor antagonist lorglumide resulted in increased saline intake. These observations extend the potential role of gastrointestinal peptides in the modulation of ingestive behavior...
  75. ncbi Mechanism of cholecystokinin-A- receptor antagonist on human pancreatic exocrine secretion. Localization of CCK-A receptor in the human duodenum
    A Funakoshi
    Department of Gastroenterology, National Kyushu Cancer Center, Fukuoka, Japan
    Digestion 60:75-80. 1999
    ..These results suggest that localization of CCK-A receptor in human duodenum provides a biochemical and morphological basis for some physiological functions of CCK...
  76. ncbi Elevation of feed intake in parasite-infected lambs by central administration of a cholecystokinin receptor antagonist
    R A Dynes
    Animal and Veterinary Sciences Group, Lincoln University, Canterbury, New Zealand
    Br J Nutr 79:47-54. 1998
    ..They do not support the singular importance of a peripheral action of CCK in determining satiety...
  77. ncbi CCK-resistance in Zucker obese versus lean rats
    C Niederau
    Department of Medicine, Heinrich Heine University, Dusseldorf, Germany
    Regul Pept 70:97-104. 1997
    ..However, the failure of the CCK-A antagonist to increase food intake questions whether any of the effects of exogenous CCK are of physiological relevance...
  78. ncbi Potentiation by baclofen of gastric acid secretion stimulated by secretagogues in vagotomized rats under anesthesia
    - Lin W-C
    Department of Pharmacology, China Medical College, Taiwan
    Res Commun Mol Pathol Pharmacol 91:211-24. 1996
    ..Baclofen-potentiated acid secretion evoked by direct vagal stimulation was prevented by pretreatment with proglumide which is a gastrin receptor antagonist...
  79. ncbi Synergistic interactions between human transfected adenosine A1 receptors and endogenous cholecystokinin receptors in CHO cells
    J M Dickenson
    Department of Physiology and Pharmacology, Medical School, Queen s Medical Centre, Nottingham, UK
    Eur J Pharmacol 302:141-51. 1996
    ....
  80. ncbi Characterization of the receptors and mechanisms involved in the cardiovascular actions of sCCK-8 in the pithed rat
    A J Gaw
    Peptic Ulceration Group, Pharmacology I, Glaxo Research and Development Ltd, Ware, Herts
    Br J Pharmacol 115:660-4. 1995
    ..The observed bradycardia was also mediated byCCKA receptors but possibly through a direct action on the heart...
  81. ncbi Cholinergic stimulatory effect of intragastric administration of a prostaglandin E2 analogue on pancreatic exocrine secretion in conscious rats
    M Masuda
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan
    Pancreas 10:395-400. 1995
    ..Therefore, intragastric administration of enprostil seemed to stimulate pancreatic exocrine secretion via a peripheral gastro-(entero)-pancreatic reflex...
  82. ncbi CGRP(8-37) and CGRP(32-37) contract the iris sphincter in the rabbit eye: antagonism by spantide and GR82334
    S E Andersson
    Department of Physiology and Medical Biophysics, Uppsala University, Sweden
    Regul Pept 49:73-80. 1993
    ..We conclude that CGRP(8-37) and CGRP(32-37) are miotic agents in the rabbit eye, possibly by acting as neurokinin receptor agonists...
  83. ncbi Influence of cholecystokinin antagonist on the effects of cholecystokinin and bombesin on azaserine-induced lesions in rat pancreas
    B R Douglas
    Department of Gastroenterology and Hepatology, University Hospital, Leiden, The Netherlands
    Gastroenterology 96:462-9. 1989
    ....
  84. ncbi Effects of CCK-receptor antagonists on CCK-stimulated pepsinogen secretion and calcium increase in isolated guinea pig gastric chief cells
    C Sakamoto
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    Dig Dis Sci 35:873-8. 1990
    ..These results suggest that L-364,718 and CR1409 act as CCK-receptor antagonists, but dbcGMP has another inhibitory effect on pepsinogen secretion in addition to the effect as a CCK-receptor antagonist in guinea pig gastric chief cells...
  85. ncbi [Effect of gastrin and enprostil, a PGE2 analog, on colonic cancerous cell growth]
    S Yactayo
    Laboratoire de Recherches, Hopital Laennec, Nantes
    Gastroenterol Clin Biol 15:519-24. 1991
    The effects of gastrin (G-17), proglumide (a gastrin receptor antagonist), and enprostil (a synthetic analog of prostaglandin E2) used alone or in association were studied in colonic cancer Prob and Regb cell growth...
  86. ncbi Role of 5-HT receptors in the effect of d-fenfluramine on gastric emptying and feeding behaviour as examined in the runway test
    R Samanin
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur J Pharmacol 197:69-73. 1991
    ..While there is evidence that DF hastens the termination of the meal by a 5-HT mechanism, the data suggest that DF may prolong the satiating effect of food during the post-absorptive phase by mechanisms other than 5-HT...
  87. ncbi The effect of cholecystokinin antagonism on postprandial lower oesophageal sphincter function in asymptomatic volunteers and patients with reflux disease
    N J Trudgill
    Department of Gastroenterology, Northern General Hospital, Sheffield, United Kingdom
    Aliment Pharmacol Ther 15:1357-64. 2001
    ..loxiglumide 31 (0-1472) seconds (N.S.)]. CONCLUSIONS: Loxiglumide inhibits TLOSR and attenuates the fall in LOS pressure following a meal, but has only modest effects on postprandial gastro-oesophageal acid reflux...
  88. ncbi Opioid and cholecystokinin antagonists alleviate gastric inhibition of food intake by premeal loads of casein in meal-fed rats
    M A Froetschel
    Animal and Dairy Science Department, The University of Georgia, Athens, GA 30602, USA
    J Nutr 131:3270-6. 2001
    ..01) by opioid antagonists. Satiety associated with premeal loads of casein is related to changes in gastrointestinal function of meal-fed animals and involves both opioid and CCK regulation...
  89. ncbi Long-term effects of proglumide on resection of cardiac adenocarcinoma
    Yu Ping Chen
    Department of Thoracic Surgery, Tumor Hospital of Shantou University Medical College, Shantou 515031, Guangdong Province, China
    World J Gastroenterol 11:2549-51. 2005
    ..Peptide hormone gastrin is a recognized growth factor for gastric cancer, and gastrin receptor antagonist proglumide can block the effects of gastrin...
  90. ncbi Use of a hepta-Tyr antibiotic modified silica stationary phase for the enantiomeric resolution of D,L-loxiglumide by electrochromatography and nano-liquid chromatography
    Salvatore Fanali
    Istituto di Metodologie Chimiche del Consiglio Nazionale delle Ricerche, Area della Ricerca di Roma 1, Monterotondo Scalo, Rome, Italy
    J Chromatogr A 1051:247-52. 2004
    ..The nano-LC optimised method was therefore validated and applied to the analysis of a pharmaceutical formulation declared to contain only D-loxiglumide...
  91. ncbi Involvement of cholecystokinin in the opioid tolerance induced by dipyrone (metamizol) microinjections into the periaqueductal gray matter of rats
    Victor Tortorici
    Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 21827, Caracas 1020A, Venezuela
    Pain 112:113-20. 2004
    ..5 microl) into the same site, as evaluated by the tail flick and hot plate tests. Microinjection of proglumide (0.4 microg/0...
  92. ncbi Effect of lipopolysaccharide on expression and characterization of cholecystokinin receptors in rat pulmonary interstitial macrophages
    Shun-Jiang Xu
    Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China
    Acta Pharmacol Sin 25:1347-53. 2004
    ..19 +/- 0.06 micromol/L) and CCK-BR specific antagonist CR2945 (IC50 = 3.2 +/- 0.1 nmol/L). CONCLUSION: Two types of functional CCK-AR and CCK-BR existed in rat PIMs and their expression could be upregulated by LPS...
  93. ncbi Full and partial agonist activity of C-terminal cholecystokinin peptides at the cloned human CCK-A receptor expressed in Chinese hamster ovary cells
    J Dunlop
    Wyeth Ayerst Research, Princeton, NJ 08540, USA
    Peptides 18:865-8. 1997
    ..These results demonstrate that CCK-8S represents the minimum ligand requirement for both high affinity and full agonist activity at the human CCK-A receptor subtype...
  94. ncbi Glycine-extended gastrin induces matrix metalloproteinase-1- and -3-mediated invasion of human colon cancer cells through type I collagen gel and Matrigel
    Miyako Baba
    Department of Pathology, Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Int J Cancer 111:23-31. 2004
    ..with a broad-spectrum metalloproteinase inhibitor (CGS27023A) and nonselective gastrin/CCK receptor antagonists (proglumide and benzotript). But a gastrin/CCK-B receptor antagonist (YM022) did not inhibit the increased invasion by G-Gly...
  95. ncbi Sensitive SPE-HPLC method to determine a novel angiotensin-AT1 antagonist in biological samples
    M Rizzo
    Dipartimento di Scienze Farmacobiologiche, Università degli Studi Magna Graecia di Catanzaro, Complesso Nini Barbieri, Roccelletta di Borgia CZ 88021, Italy
    J Pharm Biomed Anal 35:321-9. 2004
    ..The sensitivity of the method allowed for its application to pharmacokinetic studies...
  96. ncbi CCK-1 receptor blockade for treatment of biliary colic: a pilot study
    A Malesci
    Department of Internal Medicine, University of Milan, Milano, Italy
    Aliment Pharmacol Ther 18:333-7. 2003
    ..Loxiglumide is a potent and selective cholecystokinin-1 (CCK-1) receptor antagonist able to inhibit gall-bladder contraction...
  97. ncbi Differential mechanism and site of action of CCK on the pancreatic secretion and growth in rats
    Mitsuyoshi Yamamoto
    Third Dept. of Internal Medicine, Univ. of Occupational and Environmental Health, Japan, School of Medicine, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu 807-8555, Japan
    Am J Physiol Gastrointest Liver Physiol 285:G681-7. 2003
    ....
  98. ncbi Involvement of local cholecystokinin in the tolerance induced by morphine microinjections into the periaqueductal gray of rats
    Victor Tortorici
    Instituto Venezolano de Investigaciones Cienti ficas IVIC, Apartado 21827, 1020 A, Caracas, Venezuela
    Pain 102:9-16. 2003
    ..MOR microinjection was preceded (within 15 min) by a microinjection of the non-selective CCK receptor antagonist proglumide (PRO), (0.4 microg in 0...
  99. ncbi Role for the cholecystokinin-A receptor in fever: a study of a mutant rat strain and a pharmacological analysis
    Andrei I Ivanov
    Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Physiol 547:941-9. 2003
    ..None of the three known phases of the febrile response of rats to LPS requires the CCK-A receptor...

Research Grants30

  1. MINIMAL ENTERAL NUTRIENT REQUIREMENTS IN NEONATES
    Douglas Burrin; Fiscal Year: 1999
    ..absence of minimal enteral nutrients, or by inhibition of gastrin action, using the gastrin receptor antagonist, proglumide, in the presence of minimal enteral nutrients...
  2. 5-HT3 receptor mediation of 5-HT & CCK-induced satiation
    Matthew Hayes; Fiscal Year: 2005
    ....
  3. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2007
    ..To study the specific aims of the project the effects of RTX will be examined in rats by behavioral methods; and whole cell voltage-clamp technique will be used to identify a mechanism for impulse failure induced by RTX. ..
  4. Distributed neural control of energy expenditure
    Matthew Hayes; Fiscal Year: 2007
    ....
  5. BOLD Prediction of Success in a Weight Loss Program
    James Cox; Fiscal Year: 2007
    ..We wish to determine whether long-term weight-loss is related to the amount of activation elicited by these images prior to the program and to the degree to which activation is normalized in a scan after completion of the program. ..
  6. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
    ....
  7. OPIOID-BENZODIAZEPINE INTERACTIONS
    Igor Kissin; Fiscal Year: 1993
    ....
  8. Role of NTS POMC neurons in energy homeostasis
    SUZANNE APPLEYARD; Fiscal Year: 2007
    ..abstract_text> ..