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Genomes and Genes | YRA1SummaryGene Symbol: YRA1 Description: Yra1p Alias: SHE11 Species: Top Publications
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YRA1 autoregulation requires nuclear export and cytoplasmic Edc3p-mediated degradation of its pre-mRNAShuyun Dong
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Mol Cell 25:559-73. 2007..We show that YRA1 exon 1 sequences in cis and Yra1p in trans inhibit YRA1 pre-mRNA splicing and commit the pre-mRNA to nuclear export...- The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instabilityCristina González-Aguilera
Centro Andaluz de Biologia Molecular y Medicina Regenerativa, Universidad de Sevilla CSIC, 41092 Sevilla, Spain
Mol Biol Cell 19:4310-8. 2008.... - The yeast hnRNP-Like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67pD Zenklusen
Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, 1012 Lausanne, Switzerland
Mol Cell Biol 21:4219-32. 2001..describe a second nonessential Saccharomyces cerevisiae family member, called Yra2p, which is able to complement a YRA1 deletion when overexpressed... - TREX is a conserved complex coupling transcription with messenger RNA exportKatja Strasser
BZH, University of Heidelberg, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
Nature 417:304-8. 2002The essential yeast proteins Yra1 and Sub2 are messenger RNA export factors that have conserved counterparts in metazoans, designated Aly and UAP56, respectively... - The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear poresTamas Fischer
Biochemie Zentrum Heidelberg BZH, Im Neuenheimer Feld 328, Germany
EMBO J 21:5843-52. 2002..Significantly, mutations in Sac3p or Thp1p lead to strong mRNA export defects. Taken together, our data suggest that the novel Sac3p-Thp1p complex functions by docking the mRNP to specific nucleoporins at the nuclear entrance of the NPC... - Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1pDaniel Zenklusen
Institute of Microbiology, University of Lausanne, 1011 Lausanne, Switzerland
Mol Cell Biol 22:8241-53. 2002..We also identified functional interactions between Yra1p and the exosome components Rrp45p and Rrp6p. We show that yra1, sub2, and Deltahpr1 mutants all present defects in mRNA accumulation and that deletion of RRP6 in yra1 mutants .. - Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA exportPatrizia Vinciguerra
Department of Cell Biology, Sciences III, University of Geneva, Geneva, Switzerland
EMBO J 24:813-23. 2005..The mRNA export adaptor Yra1p/REF contributes to nascent mRNP assembly and recruitment of the export receptor Mex67p. yra1 mutants exhibit mRNA export defects and a decrease in LacZ reporter and certain endogenous transcripts... - Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA exportK Strasser
BZH, Biochemie Zentrum Heidelberg, Germany
EMBO J 19:410-20. 2000..Mutants of YRA1 are impaired in nuclear poly(A)+ RNA export at restrictive growth conditions... - Rds3p is required for stable U2 snRNP recruitment to the splicing apparatusQiang Wang
Department of Biology, University of Kentucky, Lexington, Kentucky 40506 0225, USA
Mol Cell Biol 23:7339-49. 2003..Together these data establish Rds3p as an essential component of the U2 snRNP SF3b complex and suggest a new link between the nuclear processes of pre-mRNA splicing and RNA export... - Functional significance of the interaction between the mRNA-binding protein, Nab2, and the nuclear pore-associated protein, Mlp1, in mRNA exportMilo B Fasken
Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 283:27130-43. 2008..RNA and that this nab2 F73D mutant genetically interacts with alleles of two essential mRNA export genes, MEX67 and YRA1. These data provide in vivo evidence for a model of mRNA export in which Nab2 is important for targeting mRNAs to .. - Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2Pau Pascual-García
Centro de Investigacion Principe Felipe, E 46012 Valencia, Spain
Genes Dev 22:2811-22. 2008..In addition, Sus1 copurifies with the essential mRNA export factors Yra1 and Mex67, which bind to the mRNA cotranscriptionally... - Cotranscriptional recruitment of the mRNA export factor Yra1 by direct interaction with the 3' end processing factor Pcf11Sara Ann Johnson
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, USA
Mol Cell 33:215-26. 2009We investigated recruitment of the yeast mRNA export factor Yra1 to the transcription elongation complex (TEC). Previously, the Sub2 helicase subunit of TREX was proposed to recruit Yra1... - Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machineryMarius Boulos Faza
Institute of Biochemistry, ETH Zurich, Zurich, Switzerland
J Cell Biol 184:833-46. 2009..Thus, Sem1 is a versatile protein that might stabilize multiple protein complexes involved in diverse pathways... - Degradation of YRA1 Pre-mRNA in the cytoplasm requires translational repression, multiple modular intronic elements, Edc3p, and Mex67pShuyun Dong
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS Biol 8:e1000360. 2010..When shunted to the cytoplasm by autoregulated nuclear export, the intron-containing yeast YRA1 pre-mRNA evades NMD and is targeted by a cytoplasmic decay pathway mediated by the decapping activator Edc3p... - Ubiquitin-mediated mRNP dynamics and surveillance prior to budding yeast mRNA exportNahid Iglesias
Department of Cell Biology, Sciences III, 1211 Geneva 4, Switzerland
Genes Dev 24:1927-38. 2010The evolutionarily conserved mRNA export receptor Mex67/NXF1 associates with mRNAs through its adaptor, Yra1/REF, allowing mRNA ribonucleoprotein (mRNP) exit through nuclear pores... - The Ccr4-Not complex interacts with the mRNA export machineryShana C Kerr
Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, United States of America
PLoS ONE 6:e18302. 2011..However, the functional significance of this regulation is poorly understood... - Cotranscriptional association of mRNA export factor Yra1 with C-terminal domain of RNA polymerase IIApril L Mackellar
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 286:36385-95. 2011..In Saccharomyces cerevisiae, the mRNA export protein Yra1 (ALY/RNA export factor in metazoa) cotranscriptionally associates with mRNA and delivers it to the nuclear pore .. - REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear exportF Stutz
Institute of Microbiology, Lausanne, Switzerland
RNA 6:638-50. 2000..Conditional expression in yeast cells implicates Yra1 p in the export of cellular mRNAs... - The Glc7 phosphatase subunit of the cleavage and polyadenylation factor is essential for transcription termination on snoRNA genesEduard Nedea
Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada
Mol Cell 29:577-87. 2008..Swd2 is also a subunit of the Set1c histone H3K4 methyltransferase complex and is required for its stability and optimal methyltransferase activity... - Nap1 links transcription elongation, chromatin assembly, and messenger RNP complex biogenesisBrian C Del Rosario
Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908, USA
Mol Cell Biol 28:2113-24. 2008..One factor investigated is an essential mRNA export and TREX complex component, Yra1. Nap1 interacts directly with Yra1 and genetically with other TREX complex components and the mRNA export factor .. - Pml39, a novel protein of the nuclear periphery required for nuclear retention of improper messenger ribonucleoparticlesBenoit Palancade
Pores Nucléaires et Transport Nucléocytoplasmique, Unité Mixte de Recherche 144 Centre National de la Recherche Scientifique, Paris Cedex, France
Mol Biol Cell 16:5258-68. 2005..Together, these data indicate that Pml39 is an upstream effector of the Mlps, involved in the retention of improper mRNPs in the nucleus before their export... - Interactions of the yeast SF3b splicing factorQiang Wang
Department of Biology, University of Kentucky, Lexington, 40506, USA
Mol Cell Biol 25:10745-54. 2005..These data establish the concordance of yeast and mammalian SF3b complexes, implicate accessory splicing factors in U2 snRNP function, and support SF3b contribution from early pre-mRNP recognition to late steps in splicing... - Autoregulation of the mRNA export factor Yra1p requires inefficient splicing of its pre-mRNAPascal J Preker
Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
RNA 12:994-1006. 2006Yra1p is an essential RNA-binding protein that couples transcription to export. The YRA1 gene is one of only approximately 5% of genes that undergo splicing in budding yeast, and its intron is unusual in several respects, including its .. - Swt1, a novel yeast protein, functions in transcriptionSusanne Röther
Gene Center, Ludwig Maximilians University of Munich, Department of Chemistry and Biochemistry, Feodor Lynen Strasse 25, 81377 Munich, Germany
J Biol Chem 281:36518-25. 2006..Importantly, deletion of Swt1 leads to decreased transcription. Taken together, these data suggest that Swt1 functions in gene expression in conjunction with the TREX complex... - Following temperature stress, export of heat shock mRNA occurs efficiently in cells with mutations in genes normally important for mRNA exportChristiane Rollenhagen
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
Eukaryot Cell 6:505-13. 2007..Heat shock mRNA was exported efficiently in temperature-sensitive npl3, yra1, and npl3 yra1 mutant strains. Nevertheless, Yra1p was recruited to heat shock mRNA, as were Nab2p and Npl3p... - Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1pK Strasser
BZH Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
Nature 413:648-52. 2001..Here, we report a genetic interaction between YRA1 and SUB2, the gene for a DEAD box helicase involved in splicing... - Yra1 is required for S phase entry and affects Dia2 binding to replication originsSwarna Swaminathan
Department of Genetics, Cell Biology and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
Mol Cell Biol 27:4674-84. 2007..Using an affinity approach, we identified Yra1, a transcription-coupled mRNA export protein, as a Dia2 interaction partner... - A new connection of mRNP biogenesis and export with transcription-coupled repairHélène Gaillard
Departamento de Genetica, Facultad de Biologia, Universidad de Sevilla, CABIMER, CSIC Universidad de Sevilla, Avenida Americo Vespucio s n, 41092 Sevilla, Spain
Nucleic Acids Res 35:3893-906. 2007..In this study we show by molecular DNA repair analysis, that Sub2-Yra1 and Thp1-Sac3, two main mRNA export complexes, are required for efficient TCR in yeast... - The export factor Yra1 modulates mRNA 3' end processingSara A Johnson
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, USA
Nat Struct Mol Biol 18:1164-71. 2011The Saccharomyces cerevisiae mRNA export adaptor Yra1 binds the Pcf11 subunit of cleavage-polyadenylation factor CF1A that links export to 3' end formation...