Ups1p

Summary

Gene Symbol: Ups1p
Description: Ups1p
Species:

Top Publications

  1. ncbi Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p
    Hiromi Sesaki
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 173:651-8. 2006
  2. ncbi Single-gene deletions that restore mating competence to diploid yeast
    Tom Schmidlin
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    FEMS Yeast Res 8:276-86. 2008
  3. ncbi Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria
    Yasushi Tamura
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 185:1029-45. 2009
  4. ncbi Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation
    Yasushi Tamura
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    EMBO J 29:2875-87. 2010
  5. ncbi Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35
    Christoph Potting
    Institute for Genetics, Center for Molecular Medicine CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Cologne, Germany
    EMBO J 29:2888-98. 2010
  6. ncbi Distinct Functions of Evolutionary Conserved MSF1 and Late Embryogenesis Abundant (LEA)-like Domains in Mitochondria
    Brandon M Hall
    From the Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263 and
    J Biol Chem 286:39141-52. 2011

Research Grants

  1. Mitochondrial Fusion and Division
    Hiromi Sesaki; Fiscal Year: 2010

Scientific Experts

  • Hiromi Sesaki
  • Yasushi Tamura
  • Brandon M Hall
  • Christoph Potting
  • Miho Iijima
  • Tom Schmidlin
  • Kjerstin M Owens
  • Keshav K Singh
  • Tanja Engmann
  • Claudia Wilmes
  • Christof Osman
  • Thomas Langer
  • Toshiya Endo
  • Vivian MacKay
  • Daniel Lockshon
  • Brian K Kennedy
  • Matt Kaeberlein
  • Brian A Kudlow

Detail Information

Publications6

  1. ncbi Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p
    Hiromi Sesaki
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 173:651-8. 2006
    ..Here, we identify Ups1p, a novel mitochondrial protein required for the unique processing of Mgm1p and for normal mitochondrial shape...
  2. ncbi Single-gene deletions that restore mating competence to diploid yeast
    Tom Schmidlin
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    FEMS Yeast Res 8:276-86. 2008
    ..In summary, this study underscores and elaborates upon predicted pathways by which mutations restore mating function to yeast diploids and identifies new mutants warranting further study...
  3. ncbi Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria
    Yasushi Tamura
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 185:1029-45. 2009
    ..In this study, we report that two homologous intermembrane space proteins, Ups1p and Ups2p, control cardiolipin metabolism and affect the assembly state of TIM23 and its association with PAM in ..
  4. ncbi Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation
    Yasushi Tamura
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    EMBO J 29:2875-87. 2010
    b>Ups1p, Ups2p, and Ups3p are three homologous proteins that control phospholipid metabolism in the mitochondrial intermembrane space (IMS)...
  5. ncbi Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35
    Christoph Potting
    Institute for Genetics, Center for Molecular Medicine CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Cologne, Germany
    EMBO J 29:2888-98. 2010
    ..Homologues to all components of this pathway are present in higher eukaryotes, suggesting that the regulation of mitochondrial CL and PE levels is conserved in evolution...
  6. ncbi Distinct Functions of Evolutionary Conserved MSF1 and Late Embryogenesis Abundant (LEA)-like Domains in Mitochondria
    Brandon M Hall
    From the Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263 and
    J Biol Chem 286:39141-52. 2011
    ..The Ups2p MSF1 domain mediates cardiolipin depletion in the absence of Ups1p. However, the Ups2p LEA-like domain is responsible for cardiolipin depletion resulting from UPS2 overexpression...

Research Grants2

  1. Mitochondrial Fusion and Division
    Hiromi Sesaki; Fiscal Year: 2010
    ..To gain a better understanding of the pathogenesis of these diseases, we will investigate the molecular mechanisms and physiological functions of mitochondrial fusion and division. ..