UME1

Summary

Gene Symbol: UME1
Description: Ume1p
Alias: WTM3
Species:

Top Publications

  1. ncbi Analyzing chromatin remodeling complexes using shotgun proteomics and normalized spectral abundance factors
    Laurence Florens
    Stowers Institute for Medical Research, 1000 E 50th St, Kansas City, MO 64110, USA
    Methods 40:303-11. 2006
  2. ncbi Genome-wide binding map of the histone deacetylase Rpd3 in yeast
    Siavash K Kurdistani
    Department of Biological Chemistry, University of California School of Medicine, Los Angeles, California 90095, USA
    Nat Genet 31:248-54. 2002
  3. ncbi Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription
    Michael J Carrozza
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Cell 123:581-92. 2005
  4. ncbi Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex
    Michael Christopher Keogh
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 123:593-605. 2005
  5. ncbi Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex
    Michael J Carrozza
    Stowers Institute for Medical Research1000 East 50th Street, Kansas City, MO 64110, USA
    Biochim Biophys Acta 1731:77-87; discussion 75-6. 2005
  6. ncbi Direct role for the Rpd3 complex in transcriptional induction of the anaerobic DAN/TIR genes in yeast
    Odeniel Sertil
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Mol Cell Biol 27:2037-47. 2007
  7. ncbi Determining protein complex connectivity using a probabilistic deletion network derived from quantitative proteomics
    Mihaela E Sardiu
    Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
    PLoS ONE 4:e7310. 2009
  8. ncbi Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation
    Jing Zhou
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School, Shanghai 200031, China
    Nucleic Acids Res 37:3699-713. 2009
  9. ncbi Genetic identification of factors that modulate ribosomal DNA transcription in Saccharomyces cerevisiae
    Robert D Hontz
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Genetics 182:105-19. 2009
  10. ncbi Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing
    L F Pemberton
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 17:4830-41. 1997

Research Grants

  1. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Odeniel Sertil; Fiscal Year: 2005

Scientific Experts

  • L F Pemberton
  • Odeniel Sertil
  • Laurence Florens
  • Michael J Carrozza
  • Jerry L Workman
  • Michael P Washburn
  • Selene K Swanson
  • Ran Tao
  • Siavash K Kurdistani
  • Jing Zhou
  • Robert D Hontz
  • Mihaela E Sardiu
  • Bing Li
  • Scott Anderson
  • John Yates
  • Wei Jong Shia
  • Wei-Jong Shia
  • Michael Christopher Keogh
  • Michael Grunstein
  • Michael J Mallory
  • Hua Chen
  • Bing Zhou
  • Chan Gao
  • Ye Guang Chen
  • Fuquan Yang
  • Jing Dong J Han
  • Peng Xue
  • Brian A Lenzmeier
  • Jin Qiu Zhou
  • Joseph M Johnson
  • Joshua M Gilmore
  • Bo O Zhou
  • Jeffrey S Smith
  • Rachel O Niederer
  • Marjorie Fournier
  • Michael K Coleman
  • Michael J Carozza
  • Michael-Christopher Keogh
  • Jonathan S Weissman
  • Brian D Strahl
  • Stephen Buratowski
  • Charles Boone
  • Kenneth K Lee
  • Kayu Chin
  • Thanuja Punna
  • Stephanie A Morris
  • Timothy R Hughes
  • Andrew Emili
  • Nevan J Krogan
  • Sean R Collins
  • Natalie J Thompson
  • Vladimir Podolny
  • Seong Hoon Ahn
  • Maya Schuldiner
  • Tamaki Suganuma
  • Jack F Greenblatt
  • Randy Strich
  • Daniel Robyr
  • Saeed Tavazoie

Detail Information

Publications12

  1. ncbi Analyzing chromatin remodeling complexes using shotgun proteomics and normalized spectral abundance factors
    Laurence Florens
    Stowers Institute for Medical Research, 1000 E 50th St, Kansas City, MO 64110, USA
    Methods 40:303-11. 2006
    ..In this method review, we describe a reanalysis of the Rpd3/Sin3 small and large histone deacetylase complexes previously described in a tabular form to demonstrate the normalized spectral abundance factor approach...
  2. ncbi Genome-wide binding map of the histone deacetylase Rpd3 in yeast
    Siavash K Kurdistani
    Department of Biological Chemistry, University of California School of Medicine, Los Angeles, California 90095, USA
    Nat Genet 31:248-54. 2002
    We describe the genome-wide distribution of the histone deacetylase and repressor Rpd3 and its associated proteins Ume1 and Ume6 in Saccharomyces cerevisiae...
  3. ncbi Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription
    Michael J Carrozza
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Cell 123:581-92. 2005
    ..This erases transcription elongation-associated acetylation to suppress intragenic transcription initiation...
  4. ncbi Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex
    Michael Christopher Keogh
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 123:593-605. 2005
    ..The smaller complex, Rpd3C(S), shares Sin3 and Ume1 with Rpd3C(L) but contains the unique subunits Rco1 and Eaf3...
  5. ncbi Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex
    Michael J Carrozza
    Stowers Institute for Medical Research1000 East 50th Street, Kansas City, MO 64110, USA
    Biochim Biophys Acta 1731:77-87; discussion 75-6. 2005
    ..These included Rpd3, Sds3, Pho23, Dep1, Rxt2, Sin3, Ash1, Ume1, Sap30, Cti6, Rxt3 and Ume6...
  6. ncbi Direct role for the Rpd3 complex in transcriptional induction of the anaerobic DAN/TIR genes in yeast
    Odeniel Sertil
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Mol Cell Biol 27:2037-47. 2007
    ....
  7. ncbi Determining protein complex connectivity using a probabilistic deletion network derived from quantitative proteomics
    Mihaela E Sardiu
    Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
    PLoS ONE 4:e7310. 2009
    ..consists of two distinct small and large complexes that are held together by a module consisting of Rpd3, Sin3 and Ume1. The resulting representation reveals new protein-protein interactions and new submodule relationships, providing ..
  8. ncbi Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation
    Jing Zhou
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School, Shanghai 200031, China
    Nucleic Acids Res 37:3699-713. 2009
    ..Together, these data provide insight into the molecular mechanisms for the anti-silencing functions of Rpd3p during the formation of heterochromatin boundaries...
  9. ncbi Genetic identification of factors that modulate ribosomal DNA transcription in Saccharomyces cerevisiae
    Robert D Hontz
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Genetics 182:105-19. 2009
    ..Fourteen genes were previously uncharacterized and have been named as regulators of rDNA transcription (RRT)...
  10. ncbi Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing
    L F Pemberton
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 17:4830-41. 1997
    ..These data suggested that Wtm1p and Wtm2p are repressors and that Wtm3p has different effects on transcription at different loci...
  11. ncbi Ume1p represses meiotic gene transcription in Saccharomyces cerevisiae through interaction with the histone deacetylase Rpd3p
    Michael J Mallory
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 278:44727-34. 2003
    ..In addition, these results suggest that Rpd3-Ume1p-Sin3p comprises an interdependent complex required for mediating transcriptional repression...
  12. ncbi Xbp1-mediated histone H4 deacetylation contributes to DNA double-strand break repair in yeast
    Ran Tao
    The State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Cell Res 21:1619-33. 2011
    ..Together, our findings reveal a role for Xbp1 in DSB repair via NHEJ through regulation of histone H4 acetylation and nucleosome displacement in a positive feedback manner...

Research Grants1

  1. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Odeniel Sertil; Fiscal Year: 2005
    ..This work will further our knowledge on what might be considered a type of metabolically induced differentiation and could open up a fairly extensive area of inquiry, possibly in antifungal drug development. ..