UBP10

Summary

Gene Symbol: UBP10
Description: Ubp10p
Alias: DOT4
Species:

Top Publications

  1. ncbi Sem1p and Ubp6p orchestrate telomeric silencing by modulating histone H2B ubiquitination and H3 acetylation
    Song Qin
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 37:1843-53. 2009
  2. ncbi Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing
    N C Tolga Emre
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19024, USA
    Mol Cell 17:585-94. 2005
  3. ncbi Ubiquitin-dependent protein degradation
    M Hochstrasser
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
    Annu Rev Genet 30:405-39. 1996
  4. ncbi Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability
    Mahesh B Chandrasekharan
    Department of Biochemistry and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 106:16686-91. 2009
  5. ncbi Polyubiquitylation of histone H2B
    Fuqiang Geng
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Mol Biol Cell 19:3616-24. 2008
  6. ncbi Genetic interactions of a putative Arabidopsis thaliana ubiquitin-ligase with components of the Saccharomyces cerevisiae ubiquitination machinery
    Laura Aguilar-Henonin
    Departamento de Ingeniería Genética de Plantas, Centro de Investigacion y de Estudios Avanzados, Campus Guanajuato, Apartado Postal 629, Gto, 36500, Mexico
    Curr Genet 50:257-68. 2006
  7. ncbi Involvement of the yeast metacaspase Yca1 in ubp10Delta-programmed cell death
    Maurizio Bettiga
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    FEMS Yeast Res 5:141-7. 2004
  8. ncbi Transcriptional profiling of ubp10 null mutant reveals altered subtelomeric gene expression and insurgence of oxidative stress response
    Ivan Orlandi
    Universita degli Studi di Milano Bicocca, Dipartimento di Biotecnologie e Bioscienze, Piazza della Scienza 2, 20126 Milano, Italy
    J Biol Chem 279:6414-25. 2004
  9. ncbi DOT4 links silencing and cell growth in Saccharomyces cerevisiae
    A Kahana
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 19:6608-20. 1999
  10. ncbi Histone chaperone Chz1p regulates H2B ubiquitination and subtelomeric anti-silencing
    Yakun Wan
    Institute for Systems Biology, Seattle, WA 98103, USA
    Nucleic Acids Res 38:1431-40. 2010

Scientific Experts

  • M Hochstrasser
  • Ivan Orlandi
  • Maurizio Bettiga
  • Yakun Wan
  • Song Qin
  • Mahesh B Chandrasekharan
  • Fuqiang Geng
  • Laura Aguilar-Henonin
  • N C Tolga Emre
  • Lilia Alberghina
  • Marina Vai
  • Jennifer J Smith
  • Ramsey A Saleem
  • Jung Hsien Chiang
  • Chan Hsien Lin
  • Christina E Arens
  • John D Aitchison
  • Gulzar Wani
  • Qun Zhao
  • Sukesh R Bhaumik
  • Fu Huang
  • Alo Ray
  • Zu Wen Sun
  • Altaf A Wani
  • Qien Wang
  • William P Tansey
  • A Kahana
  • Plinio Guzman
  • Jaime Bravo
  • Kristin Ingvarsdottir
  • Shelley L Berger
  • Keqin Li
  • Karl W Henry
  • Nevan J Krogan
  • Adam Wood
  • Ali Shilatifard
  • Anastasia Wyce
  • Ronen Marmorstein
  • Jack F Greenblatt
  • Luciano Calzari
  • D E Gottschling

Detail Information

Publications10

  1. ncbi Sem1p and Ubp6p orchestrate telomeric silencing by modulating histone H2B ubiquitination and H3 acetylation
    Song Qin
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 37:1843-53. 2009
    ....
  2. ncbi Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing
    N C Tolga Emre
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19024, USA
    Mol Cell 17:585-94. 2005
    ..Here, we show that the ubiquitin protease Ubp10 targets H2B for deubiquitylation, helping to localize Sir2 to the telomere...
  3. ncbi Ubiquitin-dependent protein degradation
    M Hochstrasser
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
    Annu Rev Genet 30:405-39. 1996
    ..This diversity underlies both the high substrate specificity of the ubiquitin system and the variety of regulatory mechanisms that it serves...
  4. ncbi Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability
    Mahesh B Chandrasekharan
    Department of Biochemistry and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 106:16686-91. 2009
    ....
  5. ncbi Polyubiquitylation of histone H2B
    Fuqiang Geng
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Mol Biol Cell 19:3616-24. 2008
    ..These results raise the possibility that some of the biological effects of ubiquitylation of H2B are exerted via ubiquitin chains, rather than a single ubiquitin group...
  6. ncbi Genetic interactions of a putative Arabidopsis thaliana ubiquitin-ligase with components of the Saccharomyces cerevisiae ubiquitination machinery
    Laura Aguilar-Henonin
    Departamento de Ingeniería Genética de Plantas, Centro de Investigacion y de Estudios Avanzados, Campus Guanajuato, Apartado Postal 629, Gto, 36500, Mexico
    Curr Genet 50:257-68. 2006
    ..We presuppose that our approach can be further utilized to analyze the function of this distinctive class of ubiquitin-ligases in yeast as well as in Arabidopsis...
  7. ncbi Involvement of the yeast metacaspase Yca1 in ubp10Delta-programmed cell death
    Maurizio Bettiga
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    FEMS Yeast Res 5:141-7. 2004
    b>UBP10 encodes a deubiquitinating enzyme of Saccharomyces cerevisiae. Its inactivation results in a complex phenotype characterized by a subpopulation of cells that exhibits the typical cellular markers of apoptosis...
  8. ncbi Transcriptional profiling of ubp10 null mutant reveals altered subtelomeric gene expression and insurgence of oxidative stress response
    Ivan Orlandi
    Universita degli Studi di Milano Bicocca, Dipartimento di Biotecnologie e Bioscienze, Piazza della Scienza 2, 20126 Milano, Italy
    J Biol Chem 279:6414-25. 2004
    b>UBP10 codes for a deubiquitinating enzyme of Saccharomyces cerevisiae whose loss of function determines slow growth rate and partial impairment of silencing at telomeres and HM loci...
  9. ncbi DOT4 links silencing and cell growth in Saccharomyces cerevisiae
    A Kahana
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 19:6608-20. 1999
    ..We studied the function of a recently identified gene, DOT4, that disrupts silencing when overexpressed...
  10. ncbi Histone chaperone Chz1p regulates H2B ubiquitination and subtelomeric anti-silencing
    Yakun Wan
    Institute for Systems Biology, Seattle, WA 98103, USA
    Nucleic Acids Res 38:1431-40. 2010
    ..In support of this, we show that deletion of UBP10 can antagonize the subtelomeric silencing phenotype of Deltachz1...