SCJ1

Summary

Gene Symbol: SCJ1
Description: Scj1p
Species:

Top Publications

  1. ncbi A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s
    G Schlenstedt
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 129:979-88. 1995
  2. ncbi Cer1p, a novel Hsp70-related protein required for posttranslational endoplasmic reticulum translocation in yeast
    T G Hamilton
    Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, USA
    J Biol Chem 271:30610-3. 1996
  3. ncbi A role for the DnaJ homologue Scj1p in protein folding in the yeast endoplasmic reticulum
    S Silberstein
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655 0103, USA
    J Cell Biol 143:921-33. 1998
  4. ncbi Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation
    S I Nishikawa
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Cell Biol 153:1061-70. 2001
  5. ncbi Interactions between centromere complexes in Saccharomyces cerevisiae
    Vladimir S Nekrasov
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, England
    Mol Biol Cell 14:4931-46. 2003
  6. ncbi Saccharomyces cerevisiae Rot1p is an ER-localized membrane protein that may function with BiP/Kar2p in protein folding
    Masato Takeuchi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology NAIST, 8916 5 Takayama, Ikoma, Nara 630 0192
    J Biochem 139:597-605. 2006
  7. ncbi The Saccharomyces cerevisiae YFR041C/ERJ5 gene encoding a type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum
    M Carla Famá
    IBYF CONICET, Catedra de Microbiologia, Facultad de Agronomia, Universidad de Buenos Aires, Avda San Martin 4453, C1417DSE Buenos Aires, Argentina
    Biochim Biophys Acta 1773:232-42. 2007
  8. ncbi Identification and characterization of a Jem1p ortholog of Candida albicans: dissection of Jem1p functions in karyogamy and protein quality control in Saccharomyces cerevisiae
    Tadashi Makio
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Genes Cells 13:1015-26. 2008
  9. ncbi The yeast JEM1p is a DnaJ-like protein of the endoplasmic reticulum membrane required for nuclear fusion
    S Nishikawa
    Department of Chemistry, Faculty of Science, Nagoya University, Chikusa ku, Nagoya 464 01, Japan
    J Biol Chem 272:12889-92. 1997

Scientific Experts

  • G C Flynn
  • Tadashi Makio
  • M Carla Famá
  • Masato Takeuchi
  • Vladimir S Nekrasov
  • S I Nishikawa
  • Toshiya Endo
  • T Endo
  • Takeshi Nakayama
  • Hiroyuki Nagai
  • G Schlenstedt
  • Shuh ichi Nishikawa
  • Nicolás Zacchi
  • Anne S Robinson
  • Susana Silberstein
  • Dario R Lemos
  • David Raden
  • S Silberstein
  • Aiko Hirata
  • Masahiro Oka
  • Yukio Kimata
  • Kenji Kohno
  • S Nishikawa
  • Melanie A Smith
  • Sew Peak-Chew
  • P A Silver
  • John V Kilmartin
  • T G Hamilton
  • J L Brodsky
  • S W Fewell
  • Y Kato
  • R Gilmore
  • S Harris
  • R Lill
  • B Risse

Detail Information

Publications9

  1. ncbi A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s
    G Schlenstedt
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 129:979-88. 1995
    ..The yeast SCJ1 gene encodes one of several homologues of the bacterial chaperone DnaJ...
  2. ncbi Cer1p, a novel Hsp70-related protein required for posttranslational endoplasmic reticulum translocation in yeast
    T G Hamilton
    Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403, USA
    J Biol Chem 271:30610-3. 1996
    ..CER1 is predicted to encode a 100-kDa polypeptide, residing in the ER lumen that is related to the hsp70 family of molecular chaperones...
  3. ncbi A role for the DnaJ homologue Scj1p in protein folding in the yeast endoplasmic reticulum
    S Silberstein
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655 0103, USA
    J Cell Biol 143:921-33. 1998
    ..physiological role of Scj1p has remained obscure due to the lack of an obvious defect in Kar2p-mediated pathways in scj1 null mutants...
  4. ncbi Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation
    S I Nishikawa
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Cell Biol 153:1061-70. 2001
    ..In contrast, deletion of JEM1 and SCJ1 had little effect on the ERAD of a membrane protein...
  5. ncbi Interactions between centromere complexes in Saccharomyces cerevisiae
    Vladimir S Nekrasov
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, England
    Mol Biol Cell 14:4931-46. 2003
    ..These results show an increasingly complex structure for the S. cerevisiae centromere and a probable conservation of structure between parts of the centromeres of S. cerevisiae and S. pombe...
  6. ncbi Saccharomyces cerevisiae Rot1p is an ER-localized membrane protein that may function with BiP/Kar2p in protein folding
    Masato Takeuchi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology NAIST, 8916 5 Takayama, Ikoma, Nara 630 0192
    J Biochem 139:597-605. 2006
    ..This implies that the protein folding machinery in which Rot1p is involved chaperones proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies...
  7. ncbi The Saccharomyces cerevisiae YFR041C/ERJ5 gene encoding a type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum
    M Carla Famá
    IBYF CONICET, Catedra de Microbiologia, Facultad de Agronomia, Universidad de Buenos Aires, Avda San Martin 4453, C1417DSE Buenos Aires, Argentina
    Biochim Biophys Acta 1773:232-42. 2007
    ..We found that loss of the non-essential ERJ5 gene leads to a constitutively induced UPR, indicating that ERJ5 is required for maintenance of an optimal folding environment in the yeast ER...
  8. ncbi Identification and characterization of a Jem1p ortholog of Candida albicans: dissection of Jem1p functions in karyogamy and protein quality control in Saccharomyces cerevisiae
    Tadashi Makio
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Genes Cells 13:1015-26. 2008
    ..Since the interaction of CaJem1p with Nep98p is weaker than that of ScJem1p, the Nep98p-ScJem1p interaction is likely important for promoting karyogamy in S. cerevisiae...
  9. ncbi The yeast JEM1p is a DnaJ-like protein of the endoplasmic reticulum membrane required for nuclear fusion
    S Nishikawa
    Department of Chemistry, Faculty of Science, Nagoya University, Chikusa ku, Nagoya 464 01, Japan
    J Biol Chem 272:12889-92. 1997
    ..The JEM1 gene is not essential for cell growth, but double disruption of the JEM1 gene and the SCJ1 gene, which encodes another DnaJ-like protein in the ER lumen, causes growth arrest at elevated temperature...