RTT107

Summary

Gene Symbol: RTT107
Description: Rtt107p
Alias: ESC4
Species:

Top Publications

  1. ncbi Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance
    D T Scholes
    Molecular Genetics Program, Wadsworth Center and School of Public Health, State University of New York, Albany, New York 12201 2002, USA
    Genetics 159:1449-65. 2001
  2. ncbi Esc4/Rtt107 and the control of recombination during replication
    Jodie K Chin
    Department of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    DNA Repair (Amst) 5:618-28. 2006
  3. ncbi Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4
    Tania M Roberts
    Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Mol Biol Cell 17:539-48. 2006
  4. ncbi Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast
    Denise Hanway
    Department of Chemistry and Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:10605-10. 2002
  5. ncbi Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage
    John Rouse
    MRC Protein Phosphorylation Unit, Wellcome Trust Biocentre Medical Sciences Institute, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 23:1188-97. 2004
  6. ncbi The role of replication bypass pathways in dicentric chromosome formation in budding yeast
    Andrew L Paek
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 186:1161-73. 2010
  7. ncbi Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway
    Nancy Lévesque
    Department of Medical Genetics, University of British Columbia, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Vancouver, British Columbia V5Z 4H4, Canada
    J Biol Chem 285:35113-22. 2010
  8. ncbi DNA damage signaling recruits the Rtt107-Slx4 scaffolds via Dpb11 to mediate replication stress response
    Patrice Y Ohouo
    Graduate Program in Biochemistry, Molecular and Cell Biology, Weill Institute for Cell and Molecular Biology, Cornell University, 339 Weill Hall, Ithaca, New York 14853 7202, USA
    Mol Cell 39:300-6. 2010
  9. ncbi Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing
    Satoru Mimura
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 285:9858-67. 2010
  10. ncbi Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA
    Iram Waris Zaidi
    Institute of Biochemistry, Swiss Federal Institute of Technology Zurich ETH, ETH Hoenggerberg, 8093 Zurich, Switzerland
    EMBO Rep 9:1034-40. 2008

Scientific Experts

  • John Rouse
  • David C Zappulla
  • Tania M Roberts
  • Grace P Leung
  • Michael S Kobor
  • Iram Waris Zaidi
  • Jodie K Chin
  • Thorsten I Schmidt
  • Nancy Lévesque
  • Satoru Mimura
  • Patrice Y Ohouo
  • Andrew L Paek
  • Matthias Peter
  • Grant W Brown
  • E L Baldwin
  • Anandi S Karumbati
  • Floyd E Romesberg
  • Denise Hanway
  • D T Scholes
  • Katsuhiko Shirahige
  • Linda Lee
  • Chikashi Obuse
  • Francisco M Bastos de Oliveira
  • Marcus B Smolka
  • Ted Weinert
  • Salma Kaochar
  • Beatriz S Almeida
  • Hope Jones
  • Tsuyoshi Yamaguchi
  • Emiko Noro
  • Takumi Kamura
  • Satoru Ishii
  • Alexandra K Fok
  • Tomoya Katsura
  • Kay Hofmann
  • Johan Malmstrom
  • Gwénaël Rabut
  • Brian Luke
  • Jessica A Vaisica
  • Ana Poveda
  • Helle Ulrich
  • Philippe Pasero
  • Hartmut Scheel
  • Suzanne A Bastin-Shanower
  • Jasper Rine
  • Vladimir I Bashkirov
  • Steven J Brill
  • Wolf Dietrich Heyer
  • Andrew Emili
  • Miki Ii
  • Jennifer W Gin
  • Wolf-Dietrich Heyer
  • Sonja A Horte
  • A C Berger
  • N Osheroff
  • Thomas E Wilson
  • A H Corbett
  • Gang Xia
  • Elizabeth A Winzeler
  • Guy Oshiro
  • M Banerjee
  • M J Curcio
  • B Bowen

Detail Information

Publications15

  1. ncbi Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance
    D T Scholes
    Molecular Genetics Program, Wadsworth Center and School of Public Health, State University of New York, Albany, New York 12201 2002, USA
    Genetics 159:1449-65. 2001
    ..The regulation of Ty1 transposition by components of fundamental pathways required for genome maintenance suggests that Ty1 and yeast have coevolved to link transpositional dormancy to the integrity of the genome...
  2. ncbi Esc4/Rtt107 and the control of recombination during replication
    Jodie K Chin
    Department of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    DNA Repair (Amst) 5:618-28. 2006
    ..In Saccharomyces cerevisiae, Esc4 contains six such BRCT domains and is required for the most efficient response to a variety of agents that damage ..
  3. ncbi Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4
    Tania M Roberts
    Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Mol Biol Cell 17:539-48. 2006
    b>RTT107 (ESC4, YHR154W) encodes a BRCA1 C-terminal-domain protein that is important for recovery from DNA damage during S phase...
  4. ncbi Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast
    Denise Hanway
    Department of Chemistry and Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:10605-10. 2002
    ..Epistatsis analysis of four of the genes was performed to determine the DNA damage repair pathways in which the protein products function...
  5. ncbi Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage
    John Rouse
    MRC Protein Phosphorylation Unit, Wellcome Trust Biocentre Medical Sciences Institute, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 23:1188-97. 2004
    ..These results identify Esc4p as an important new S-phase-specific target of Mec1p...
  6. ncbi The role of replication bypass pathways in dicentric chromosome formation in budding yeast
    Andrew L Paek
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 186:1161-73. 2010
    ..Fourth, by studying genes implicated in suppression of GCRs in other studies, we found that inverted repeat fusion has a profile of genetic regulation distinct from these other major forms of GCR formation...
  7. ncbi Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway
    Nancy Lévesque
    Department of Medical Genetics, University of British Columbia, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Vancouver, British Columbia V5Z 4H4, Canada
    J Biol Chem 285:35113-22. 2010
    ..In Saccharomyces cerevisiae, the BRCA1 C-terminal domain-containing protein Rtt107/Esc4 is required for restart of DNA replication after successful repair of DNA damage and for cellular resistance ..
  8. ncbi DNA damage signaling recruits the Rtt107-Slx4 scaffolds via Dpb11 to mediate replication stress response
    Patrice Y Ohouo
    Graduate Program in Biochemistry, Molecular and Cell Biology, Weill Institute for Cell and Molecular Biology, Cornell University, 339 Weill Hall, Ithaca, New York 14853 7202, USA
    Mol Cell 39:300-6. 2010
    ..we found that Mec1 mediates a key interaction between the fork protein Dpb11 and the DNA repair scaffolds Slx4-Rtt107 to regulate replication stress response...
  9. ncbi Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing
    Satoru Mimura
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 285:9858-67. 2010
    ..Genetic evidence indicates that Cul8, together with Mms1, Mms22, and Esc4, is involved in the repair of DNA damage that can occur during DNA replication...
  10. ncbi Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA
    Iram Waris Zaidi
    Institute of Biochemistry, Swiss Federal Institute of Technology Zurich ETH, ETH Hoenggerberg, 8093 Zurich, Switzerland
    EMBO Rep 9:1034-40. 2008
    ..Taken together, our data suggest that the Rtt101(Mms1) ubiquitin ligase complex might be required to reorganize replication forks that encounter DNA lesions...
  11. ncbi Regulation of rtt107 recruitment to stalled DNA replication forks by the cullin rtt101 and the rtt109 acetyltransferase
    Tania M Roberts
    Department of Biochemistry and Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Mol Biol Cell 19:171-80. 2008
    b>RTT107 (ESC4, YHR154W) encodes a BRCA1 C-terminal domain protein that is important for recovery from DNA damage during S phase...
  12. ncbi Rtt107/Esc4 binds silent chromatin and DNA repair proteins using different BRCT motifs
    David C Zappulla
    Department of Biochemistry and Cellular Biology, Stony Brook University, Stony Brook, NY 11794, USA
    BMC Mol Biol 7:40. 2006
    ..silencing when targeted to the HMR locus in Saccharomyces cerevisiae, we previously reported the identification of Rtt107/Esc4 based on its ability to establish silent chromatin...
  13. ncbi Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II
    E L Baldwin
    Department of Biochemistry, Vanderbilt University School of Medicine Nashville, TN 37232 0146, USA
    Nucleic Acids Res 33:1021-30. 2005
    ..MMS22 is epistatic with RTT101 and RTT107, genes that encode its protein binding partners...
  14. ncbi Abrogation of the Chk1-Pds1 checkpoint leads to tolerance of persistent single-strand breaks in Saccharomyces cerevisiae
    Anandi S Karumbati
    Department of Pathology, University of Michigan Medical School, Ann Arbor, 48109 0602, USA
    Genetics 169:1833-44. 2005
    ..We propose a model in which recombinational repair during S phase coupled with failure of the metaphase-anaphase checkpoint allows for tolerance of persistent single-strand breaks at the expense of genome stability...
  15. ncbi Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks
    Grace P Leung
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    J Biol Chem 286:26250-7. 2011
    ..In Saccharomyces cerevisiae, the BRCT domain-containing protein Rtt107/Esc4 is required for the restart of DNA replication after successful repair of DNA damage and for cellular ..