MSL5

Summary

Gene Symbol: MSL5
Description: Msl5p
Species:

Top Publications

  1. ncbi A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicing
    B Rutz
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    EMBO J 19:1873-86. 2000
  2. ncbi Transient interaction of BBP/ScSF1 and Mud2 with the splicing machinery affects the kinetics of spliceosome assembly
    B Rutz
    European Molecular Biology Laboratory, Heidelberg, Germany
    RNA 5:819-31. 1999
  3. ncbi Mer1p is a modular splicing factor whose function depends on the conserved U2 snRNP protein Snu17p
    Marc Spingola
    Center for the Molecular Biology of RNA, Sinsheimer Laboratories, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Nucleic Acids Res 32:1242-50. 2004
  4. ncbi Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals
    N Abovich
    Howard Hughes Medical Institute, Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    Cell 89:403-12. 1997
  5. ncbi The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC
    J A Berglund
    Howard Hughes Medical Institute, Department of Biology and Biochemistry, Brandeis University, Waltham, Massachusetts 02254, USA
    Cell 89:781-7. 1997
  6. ncbi Cotranscriptional spliceosome assembly occurs in a stepwise fashion and requires the cap binding complex
    Janina Görnemann
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Mol Cell 19:53-63. 2005
  7. ncbi An extended RNA binding site for the yeast branch point-binding protein and the role of its zinc knuckle domains in RNA binding
    Stephen M Garrey
    Department of Chemistry and Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403 1229, USA
    J Biol Chem 281:27443-53. 2006
  8. ncbi A BBP-Mud2p heterodimer mediates branchpoint recognition and influences splicing substrate abundance in budding yeast
    Qiang Wang
    Department of Biology and Department of Chemistry, University of Kentucky, Lexington, KY 40506 0225, USA
    Nucleic Acids Res 36:2787-98. 2008

Research Grants

  1. Regulation of mRNA Splicing by Mer1p
    Marc Spingola; Fiscal Year: 2007

Scientific Experts

  • Marc Spingola
  • B Seraphin
  • B Rutz
  • Qiang Wang
  • Stephen M Garrey
  • Janina Görnemann
  • N Abovich
  • Li Zhang
  • Brian C Rymond
  • Bert Lynn
  • J Andrew Berglund
  • Rodger Voelker
  • Karla M Neugebauer
  • Katja Hujer
  • Kimberly M Kotovic
  • M Rosbash
  • J A Berglund
  • K Chua
  • R Reed

Detail Information

Publications8

  1. ncbi A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicing
    B Rutz
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    EMBO J 19:1873-86. 2000
    The MSL5 gene, which codes for the splicing factor BBP/ScSF1, is essential in Saccharomyces cerevisiae, yet previous analyses failed to reveal a defect in assembly of (pre)-spliceosomes or in vitro splicing associated with its depletion...
  2. ncbi Transient interaction of BBP/ScSF1 and Mud2 with the splicing machinery affects the kinetics of spliceosome assembly
    B Rutz
    European Molecular Biology Laboratory, Heidelberg, Germany
    RNA 5:819-31. 1999
    ..These observations support a model in which BBP and Mud2 are recycled during transition from CC2 to pre-spliceosome...
  3. ncbi Mer1p is a modular splicing factor whose function depends on the conserved U2 snRNP protein Snu17p
    Marc Spingola
    Center for the Molecular Biology of RNA, Sinsheimer Laboratories, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Nucleic Acids Res 32:1242-50. 2004
    ..We conclude that Mer1p is a modular splicing regulator that can activate splicing at several early steps of spliceosome assembly and depends on the activities of both U1 and U2 snRNP proteins to activate splicing...
  4. ncbi Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals
    N Abovich
    Howard Hughes Medical Institute, Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    Cell 89:403-12. 1997
    ..Our results show that SF1 interacts strongly with human U2AF65, and that SF1 is a bona fide E complex component. This implies that aspects of these novel cross-intron protein-protein interactions are conserved between yeast and mammals...
  5. ncbi The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC
    J A Berglund
    Howard Hughes Medical Institute, Department of Biology and Biochemistry, Brandeis University, Waltham, Massachusetts 02254, USA
    Cell 89:781-7. 1997
    ..The relative conservation of this region in yeast and mammals correlates well with the RNA-binding differences between BBP and mBBP, suggesting that BBP contributes to branchpoint sequence definition in both systems...
  6. ncbi Cotranscriptional spliceosome assembly occurs in a stepwise fashion and requires the cap binding complex
    Janina Görnemann
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Mol Cell 19:53-63. 2005
    ..Thus, the demonstration of an essential link between CBC and spliceosome assembly in vivo indicates that 5' end capping couples pre-mRNA splicing to transcription...
  7. ncbi An extended RNA binding site for the yeast branch point-binding protein and the role of its zinc knuckle domains in RNA binding
    Stephen M Garrey
    Department of Chemistry and Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403 1229, USA
    J Biol Chem 281:27443-53. 2006
    ..The lack of involvement of the second highly conserved zinc knuckle in RNA binding suggests that this zinc knuckle plays a different role in RNA processing than enhancing the binding of BBP to the BPS...
  8. ncbi A BBP-Mud2p heterodimer mediates branchpoint recognition and influences splicing substrate abundance in budding yeast
    Qiang Wang
    Department of Biology and Department of Chemistry, University of Kentucky, Lexington, KY 40506 0225, USA
    Nucleic Acids Res 36:2787-98. 2008
    ..In addition, our results suggest the possibility that the Mud2p may enhance the turnover of pre-mRNA with impaired BBP-branchpoint association...

Research Grants1

  1. Regulation of mRNA Splicing by Mer1p
    Marc Spingola; Fiscal Year: 2007
    ..This project will elucidate how Mer1p and similar proteins function and will offer important insights towards the basis of diseases like Fragile X Syndrome in humans. ..