Csf2

Summary

Gene Symbol: Csf2
Description: colony stimulating factor 2 (granulocyte-macrophage)
Alias: Csfgm, Gm-CSf, MGI-IGM, CSF, colony-stimulating factor, granulocyte-macrophage colony stimulating factor 2, granulocyte-macrophage colony-stimulating factor, put. GM-CSF
Species: mouse

Top Publications

  1. ncbi Effect of granulocyte-macrophage colony-stimulating factor deficiency on ovarian follicular cell function
    R B Gilchrist
    The Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, The University of Adelaide, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia
    J Reprod Fertil 120:283-92. 2000
  2. ncbi Bone marrow and splenic granulocyte-macrophage colony-stimulating factor and transforming growth factor-beta mRNA levels in irradiated mice
    C M Chang
    Department of Experimental Hematology, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Blood 86:2130-6. 1995
  3. ncbi GM-CSF induces STAT5 binding at epigenetic regulatory sites within the Csf2 promoter of non-obese diabetic (NOD) mouse myeloid cells
    F Seydel
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    J Autoimmun 31:377-84. 2008
  4. ncbi GM-CSF deficiency reduces macrophage PPAR-gamma expression and aggravates atherosclerosis in ApoE-deficient mice
    Michael Ditiatkovski
    Cell Biology Laboratory, Monash University, Melbourne, Victoria, 8008, Australia
    Arterioscler Thromb Vasc Biol 26:2337-44. 2006
  5. ncbi GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1
    Y Shibata
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Immunity 15:557-67. 2001
  6. ncbi High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters
    S R Himes
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Immunity 5:479-89. 1996
  7. ncbi Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo
    Steven Bozinovski
    Arthritis and Inflammation Research Center, Department of Medicine, Cooperative Research Center CRC for Chronic Inflammatory Diseases, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia
    J Biol Chem 277:42808-14. 2002
  8. ncbi GM-CSF Biology
    John A Hamilton
    Department of Medicine, Arthritis and Inflammation Research Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville 3010 Vic, Australia
    Growth Factors 22:225-31. 2004
  9. ncbi Increased dendritic cell number and function following continuous in vivo infusion of granulocyte macrophage-colony-stimulating factor and interleukin-4
    Saroj K Basak
    Division of Pulmonary and Critical Care, Department of Medicine, UCLA School of Medicine, Los Angeles 90095 1690, USA
    Blood 99:2869-79. 2002
  10. ncbi Deficiencies of GM-CSF and interferon gamma link inflammation and cancer
    Thomas Enzler
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 197:1213-9. 2003

Research Grants

  1. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 1993
  2. CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESIS
    Bethany Moore; Fiscal Year: 2002
  3. Collectin Deficiency in the mouse
    Samuel Hawgood; Fiscal Year: 2004
  4. PGE2 Regulation of Host Defense post-BMT
    Bethany Moore; Fiscal Year: 2009
  5. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
  6. GM-CSF is required for macrophage surfactant catabolism
    Tracey Bonfield; Fiscal Year: 2006
  7. PGE2 Regulation of Host Defense post-BMT
    Bethany Moore; Fiscal Year: 2007
  8. Cytokine Dysregulation in GM-CSF Autoimmunity
    Mary Jane Thomassen; Fiscal Year: 2007
  9. NICHD Institutional Training for Pediatricians
    Samuel Hawgood; Fiscal Year: 2007
  10. Zeiss LSM 510 Laser Scanning Microscope
    Mercedes Gonzalez Juarrero; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications117 found, 100 shown here

  1. ncbi Effect of granulocyte-macrophage colony-stimulating factor deficiency on ovarian follicular cell function
    R B Gilchrist
    The Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, The University of Adelaide, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia
    J Reprod Fertil 120:283-92. 2000
    Granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine secreted by lymphohaemopoietic and other cell lineages, is known to influence ovarian cyclicity and embryo development...
  2. ncbi Bone marrow and splenic granulocyte-macrophage colony-stimulating factor and transforming growth factor-beta mRNA levels in irradiated mice
    C M Chang
    Department of Experimental Hematology, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Blood 86:2130-6. 1995
    ..radiation exposure on endogenous bone marrow (BM) and splenic granulocyte-macrophage colony-stimulating factor (GM-CSF) and transforming growth factor-beta (TGF-beta) mRNA levels were assayed in B6D2F1 female mice...
  3. ncbi GM-CSF induces STAT5 binding at epigenetic regulatory sites within the Csf2 promoter of non-obese diabetic (NOD) mouse myeloid cells
    F Seydel
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    J Autoimmun 31:377-84. 2008
    ..We found that GM-CSF can regulate the binding of STAT5 on the promoter of its own gene, Csf2, within regions previously identified as sites of chromatin epigenetic modification important to the regulation of ..
  4. ncbi GM-CSF deficiency reduces macrophage PPAR-gamma expression and aggravates atherosclerosis in ApoE-deficient mice
    Michael Ditiatkovski
    Cell Biology Laboratory, Monash University, Melbourne, Victoria, 8008, Australia
    Arterioscler Thromb Vasc Biol 26:2337-44. 2006
    Granulocyte-macrophage colony-stimulating factor (GM-CSF) is expressed in atherosclerotic lesions but its significance for lesion development is unknown...
  5. ncbi GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1
    Y Shibata
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Immunity 15:557-67. 2001
    GM-CSF gene targeted (GM(-/-)) mice are susceptible to respiratory infections and develop alveolar proteinosis due to defects in innate immune function and surfactant catabolism in alveolar macrophages (AMs), respectively...
  6. ncbi High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters
    S R Himes
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Immunity 5:479-89. 1996
    ..We show that the CK-1 element (CD28RE) within the GM-CSF promoter binds the RelA and c-Rel transcription factors in response to CD28 activation...
  7. ncbi Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo
    Steven Bozinovski
    Arthritis and Inflammation Research Center, Department of Medicine, Cooperative Research Center CRC for Chronic Inflammatory Diseases, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia
    J Biol Chem 277:42808-14. 2002
    ..the role of Akt and Erk1/2 as LPS intensely stimulates granulocyte/macrophage-colony-stimulating factor (GM-CSF) release, and neutralizing GM-CSF profoundly suppressed LPS-induced inflammation, suppressed expression and ..
  8. ncbi GM-CSF Biology
    John A Hamilton
    Department of Medicine, Arthritis and Inflammation Research Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville 3010 Vic, Australia
    Growth Factors 22:225-31. 2004
    Granulocyte macrophage-colony stimulating factor (GM-CSF) was originally defined by its ability to generate in vitro granulocyte and macrophage colonies from bone marrow precursor cells...
  9. ncbi Increased dendritic cell number and function following continuous in vivo infusion of granulocyte macrophage-colony-stimulating factor and interleukin-4
    Saroj K Basak
    Division of Pulmonary and Critical Care, Department of Medicine, UCLA School of Medicine, Los Angeles 90095 1690, USA
    Blood 99:2869-79. 2002
    ..The combination of recombinant granulocyte macrophage-colony-stimulating factor (rGM-CSF) and recombinant interleukin-4 (rIL-4) provides an important stimulus for generating DCs from murine bone marrow ..
  10. ncbi Deficiencies of GM-CSF and interferon gamma link inflammation and cancer
    Thomas Enzler
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 197:1213-9. 2003
    ..We report that aged granulocyte-macrophage colony stimulating factor (GM-CSF)-deficient mice develop a systemic lupus erythematosis (SLE)-like disorder associated with the ..
  11. ncbi Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis
    G Dranoff
    Whitehead Institute for Biomedical Research, Cambridge, MA
    Science 264:713-6. 1994
    The in vivo function of murine granulocyte-macrophage colony-stimulating factor (GM-CSF) was investigated in mice, carrying a null allele of the GM-CSF gene, that were generated by gene targeting techniques in embryonic stem cells...
  12. ncbi Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology
    E Stanley
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Victoria, Australia
    Proc Natl Acad Sci U S A 91:5592-6. 1994
    Mice homozygous for a disrupted granulocyte/macrophage colony-stimulating factor (GM-CSF) gene develop normally and show no major perturbation of hematopoiesis up to 12 weeks of age...
  13. ncbi Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis
    J L McQualter
    Neuroimmunology Laboratory, Department of Biochemistry, La Trobe University, Victoria 3086, Australia
    J Exp Med 194:873-82. 2001
    ..The hematopoietic growth factor, granulocyte macrophage colony-stimulating factor (GM-CSF), is considered to play a central role in maintaining chronic inflammation...
  14. ncbi Granulocyte macrophage colony-stimulating factor regulates dendritic cell content of atherosclerotic lesions
    Zory Shaposhnik
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 27:621-7. 2007
    ..Based primarily on previous in vitro studies, we hypothesized that granulocyte macrophage colony-stimulating factor (GM-CSF)-deficient mice would have decreased dendritic cells in lesions.
  15. ncbi GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis
    Eugene D Ponomarev
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    J Immunol 178:39-48. 2007
    ..autoimmune disease believed to be triggered by T cells secreting Th1-specific proinflammatory cytokines, such as GM-CSF. In the animal model of MS, experimental autoimmune encephalomyelitis (EAE), Th1 but not Th2 cells have been shown ..
  16. ncbi Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation
    M Kieslinger
    Institute of Molecular Pathology, Vienna Biocenter, A 1030 Vienna, Austria
    Genes Dev 14:232-44. 2000
    ..Bone marrow cells from these animals displayed a strong increase in apoptotic cell death during GM-CSF-dependent functional maturation in vitro...
  17. ncbi Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease
    Irah L King
    Interdepartmental Graduate Program in Neuroscience, School of Medicine and Dentistry, University of Rochester, NY, USA
    Blood 113:3190-7. 2009
    ....
  18. ncbi Essential roles for granulocyte-macrophage colony-stimulating factor (GM-CSF) and G-CSF in the sustained hematopoietic response of Listeria monocytogenes-infected mice
    Y Zhan
    Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia
    Blood 91:863-9. 1998
    The in vivo roles of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte (G)-CSF were studied in factor-deficient gene-targeted knockout mice infected with the facultative intracellular bacterium Listeria ..
  19. ncbi T cell functions in granulocyte/macrophage colony-stimulating factor deficient mice
    H Wada
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:12557-61. 1997
    Immunological functions were analyzed in mice lacking granulocyte/macrophage colony-stimulating factor (GM-CSF)...
  20. ncbi GM-CSF enhances a CpG-independent pathway of neutrophil activation triggered by bacterial DNA
    Juan I Fuxman Bass
    Departamento de Inmunologia, Instituto de Investigaciones Hematológicas e Instituto de Estudios Oncológicos Fundación Maissa Academia Nacional de Medicina, Buenos Aires, Argentina
    Mol Immunol 46:37-44. 2008
    ..In this study we determined that GM-CSF enhances the activation of neutrophils by bacterial DNA...
  21. ncbi Nf1 and Gmcsf interact in myeloid leukemogenesis
    R A Birnbaum
    Department of Pediatrics, University of California, San Francisco 94143 0519, USA
    Mol Cell 5:189-95. 2000
    ..JMML and murine Nf1-deficient cells are hypersensitive to granulocyte-macrophage colony-stimulating factor (GM-CSF) in methylcellulose cultures...
  22. ncbi Granulocyte macrophage colony-stimulating factor-driven respiratory mucosal sensitization induces Th2 differentiation and function independently of interleukin-4
    Stacey A Ritz
    Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, Division of Respiratory Diseases and Allergy, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 27:428-35. 2002
    ..whether IL-4 is necessary for Th2-polarized responses during granulocyte macrophage colony-stimulating factor (GM-CSF)-driven respiratory mucosal sensitization...
  23. ncbi Increased tolerance to endotoxin by granulocyte-macrophage colony-stimulating factor-deficient mice
    S Basu
    Ludwig Institute for Cancer Research, Melbourne Tumor Biology Branch, Royal Melbourne Hospital, Victoria, Australia
    J Immunol 159:1412-7. 1997
    The contribution of granulocyte-macrophage CSF (GM-CSF) to endotoxin-mediated septic shock has been assessed by treating GM-CSF-deficient mice with LPS...
  24. ncbi Overlapping roles for granulocyte-macrophage colony-stimulating factor and interleukin-3 in eosinophil homeostasis and contact hypersensitivity
    S Gillessen
    Department of Adult Oncology, Dana Farber Cancer Institute Harvard Medical School, Boston, MA, USA
    Blood 97:922-8. 2001
    Studies of mice rendered deficient in granulocyte-macrophage colony-stimulating factor (GM-CSF) or interleukin-3 (IL-3) have established unique roles for these cytokines in pulmonary homeostasis, resistance to infection, and antigen-..
  25. ncbi Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice
    I K Campbell
    Department of Medicine, Inflammation Research Center, University of Melbourne, Victoria, Australia
    J Immunol 161:3639-44. 1998
    The involvement of granulocyte-macrophage CSF (GM-CSF) in collagen-induced arthritis (CIA) was examined using GM-CSF-deficient mice...
  26. ncbi Local transgenic expression of granulocyte macrophage-colony stimulating factor initiates autoimmunity
    M Biondo
    Department of Pathology and Immunology, Monash University Medical School, Prahran, Victoria, Australia
    J Immunol 166:2090-9. 2001
    ..Here we tested whether local production of GM-CSF, a pro-inflammatory cytokine, is sufficient to break tolerance and initiate autoimmunity...
  27. ncbi Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation
    Fabio Re
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 169:2264-73. 2002
    Neonatal microglial cells respond to GM-CSF and M-CSF by acquiring different morphologies and phenotypes...
  28. ncbi GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection
    A M Levine
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 103:563-9. 1999
    Granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-targeted mice (GM-/-) cleared group B streptococcus (GBS) from the lungs more slowly than wild-type mice...
  29. ncbi Potentiation by granulocyte macrophage colony-stimulating factor of lipopolysaccharide toxicity in mice
    G Tiegs
    Department of Biochemical Pharmacology, Faculty of Biology, University of Konstanz, Germany
    J Clin Invest 93:2616-22. 1994
    GM-CSF is known to prime leukocytes for inflammatory stimuli in vitro. The objective of this study was to investigate the role of GM-CSF in vivo in a systemic inflammatory reaction syndrome...
  30. ncbi GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival
    Ivo Sonderegger
    Institute of Integrative Biology, Molecular Biomedicine, ETH Zurich, 8952 Zurich, Switzerland
    J Exp Med 205:2281-94. 2008
    Granulocyte macrophage-colony stimulating factor (GM-CSF) is critically involved in development of organ-related autoimmune inflammatory diseases including experimental allergic encephalitis and collagen-induced arthritis...
  31. ncbi Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells
    Carlos Sebastian
    Institute for Research in Biomedicine and University of Barcelona, Barcelona Science Park, Josep Samitier 105, Barcelona, Spain
    J Immunol 180:5898-906. 2008
    After interaction with its receptor, GM-CSF induces phosphorylation of the beta-chain in two distinct domains in macrophages...
  32. ncbi Granulocyte-macrophage colony-stimulating factor-deficient mice have impaired resistance to blood-stage malaria
    J Riopel
    Centre for the Study of Host Resistance, McGill University and The Montreal General Hospital Research Institute, Montreal, Quebec, Canada
    Infect Immun 69:129-36. 2001
    The contribution of granulocyte-macrophage colony-stimulating factor (GM-CSF), a hematopoietic and immunoregulatory cytokine, to resistance to blood-stage malaria was investigated by infecting GM-CSF-deficient (knockout [KO]) mice with ..
  33. ncbi A dual role for the immune response in a mouse model of inflammation-associated lung cancer
    Michael Dougan
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 121:2436-46. 2011
    ..in the development of lung cancer, we generated mice with combined loss of IFN-? and the ?-common cytokines GM-CSF and IL-3. These immunodeficient mice develop chronic pulmonary inflammation and lung tumors at a high frequency...
  34. ncbi Effects of granulocyte-macrophage colony-stimulating factor produced by intestinal epithelial cells on functional activity of hemopoietic stem cells
    S V Sennikov
    Laboratory of Hemopoiesis Regulation, Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia
    Bull Exp Biol Med 134:548-50. 2002
    ..Intestinal epithelial cells stimulates proliferative and colony-forming activity of hemopoietic stem cells by producing granulocyte-macrophage colony-stimulating factor...
  35. ncbi Upregulation of Toll-like receptor (TLR) expression and release of cytokines from P815 mast cells by GM-CSF
    Haiwei Yang
    Clinical Research Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China
    BMC Cell Biol 10:37. 2009
    ..Toll-like receptors (TLRs) on their membrane surfaces, and granulocyte-macrophage colony-stimulating factor (GM-CSF) was reported to be able to alter expression of TLRs and cytokine production in neutrophils...
  36. ncbi GM-CSF is an essential regulator of T cell activation competence in uterine dendritic cells during early pregnancy in mice
    Lachlan M Moldenhauer
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia
    J Immunol 185:7085-96. 2010
    ..GM-CSF (CSF2), a known regulator of DCs, is synthesized by uterine epithelial cells during induction of tolerance in early ..
  37. ncbi The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
    Mohamed El-Behi
    Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:568-75. 2011
    ..Here we found that IL-23 induced production of the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) in T(H)17 cells and that GM-CSF had an essential role in their encephalitogenicity...
  38. ncbi IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice
    Francesca Walker
    Ludwig Institute for Cancer Research, Melbourne Tumor Biology Branch, Melbourne, Victoria, Australia
    Blood 111:3978-85. 2008
    Mice defective in both granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have severely impaired neutrophil production and function, yet these mice respond to acute pathogen ..
  39. ncbi ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis
    Mary Jane Thomassen
    Program in Lung Cell Biology and Translational Research, Division of Pulmonary and Critical Care Medicine, East Carolina University, Greenville, NC, USA
    J Lipid Res 48:2762-8. 2007
    ..Neutralizing autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF) are also present, resulting in virtual GM-CSF deficiency...
  40. ncbi Endogenous granulocyte-macrophage colony-stimulating factor overexpression in vivo results in the long-term recruitment of a distinct dendritic cell population with enhanced immunostimulatory function
    George Miller
    Hepatobiliary Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 169:2875-85. 2002
    GM-CSF is critical for dendritic cell (DC) survival and differentiation in vitro. To study its effect on DC development and function in vivo, we used a gene transfer vector to transiently overexpress GM-CSF in mice...
  41. ncbi IL-10-producing CD4+CD25+ regulatory T cells play a critical role in granulocyte-macrophage colony-stimulating factor-induced suppression of experimental autoimmune thyroiditis
    Eryn Gangi
    Departments of Microbiology, University of Illinois, Chicago, 60612, USA
    J Immunol 174:7006-13. 2005
    Our earlier study showed that GM-CSF has the potential not only to prevent, but also to suppress, experimental autoimmune thyroiditis (EAT)...
  42. ncbi Impaired dendritic cell maturation and increased T(H)2 responses in PIR-B(-/-) mice
    Azusa Ujike
    Department of Experimental Immunology and CREST Program of JST, Institute of Development, Aging and Cancer, Tohoku University, Seiryo 4 1, Sendai 980 8575, Japan
    Nat Immunol 3:542-8. 2002
    ..Thus, PIR-B is critical for B cell suppression, DC maturation and for balancing T(H)1 and T(H)2 immune responses...
  43. ncbi GM-CSF mediates alveolar epithelial type II cell changes, but not emphysema-like pathology, in SP-D-deficient mice
    Matthias Ochs
    Division of Electron Microscopy, Department of Anatomy, University of Gottingen, Germany
    Am J Physiol Lung Cell Mol Physiol 287:L1333-41. 2004
    ..Granulocyte/macrophage colony-stimulating factor (GM-CSF) is required for terminal differentiation and subsequent activation of alveolar macrophages, including the ..
  44. ncbi Granulocyte macrophage-colony stimulating factor (GM-CSF) recruits immune cells to the pancreas and delays STZ-induced diabetes
    Michelle Krakowski
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Pathol 196:103-12. 2002
    Granulocyte macrophage-colony stimulating factor (GM-CSF) is one of the most widely used growth factors for enhancing immune responses and is known to recruit and activate antigen-presenting cells (APCs)...
  45. ncbi Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction
    Sally A Litherland
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Immunol 175:4561-5. 2005
    ..NODC11), or diabetes-resistant C57L (NOD.LC11) loci on chromosome 11. These intervals contain the gene for GM-CSF (Csf2; 53.8 Mb) and those for STAT3, STAT5A, and STAT5B (Stat3, Stat5a, and Stat5b; 100.4-100.6 Mb)...
  46. ncbi Elevated gelatinase activity in pulmonary alveolar proteinosis: role of macrophage-colony stimulating factor
    Tracey L Bonfield
    Department of Pulmonary, Allergy and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195 5038, USA
    J Leukoc Biol 79:133-9. 2006
    Pulmonary alveolar proteinosis (PAP) is an anti-granulocyte macrophage-colony stimulating factor (GM-CSF) autoimmune disease resulting in the accumulation of phospholipids in the alveoli...
  47. ncbi Lentivirus-ABCG1 instillation reduces lipid accumulation and improves lung compliance in GM-CSF knock-out mice
    Anagha Malur
    Program in Lung Cell Biology and Translational Research, Division of Pulmonary, Critical Care and Sleep Medicine, East Carolina University, Greenville, NC, United States
    Biochem Biophys Res Commun 415:288-93. 2011
    ..PAP patients also exhibit neutralizing antibodies to granulocyte-macrophage colony stimulating factor (GM-CSF), an upregulator of PPAR?...
  48. ncbi Molecular cloning and expression of gerbil granulocyte/macrophage colony-stimulating factor
    Denis Gaucher
    Institute of Parasitology, McGill University, Macdonald Campus, 21, 111 Lakeshore Road, Ste Anne de Bellevue, QC, Canada H9X 3V9
    Gene 294:233-8. 2002
    ..of cDNA ends techniques, we cloned the cDNA encoding gerbil granulocyte/macrophage colony-stimulating factor (GM-CSF)...
  49. ncbi Effect of granulocyte-macrophage colony-stimulating factor in experimental visceral leishmaniasis
    H W Murray
    Division of Infectious Diseases, Cornell University Medical College, New York 10021
    J Clin Invest 95:1183-92. 1995
    GM-CSF induces three effects potentially beneficial in visceral leishmaniasis: blood monocyte mobilization, macrophage activation, and amelioration of granulocytopenia...
  50. ncbi Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor
    N M Gough
    Nature 309:763-7. 1984
    DNA clones specifying the murine granulocyte-macrophage colony stimulating factor have been isolated...
  51. ncbi Transgenic mice in the study of cytokine function
    J Taverne
    University College London Medical School, Department of Immunology, UK
    Int J Exp Pathol 74:525-46. 1993
  52. ncbi Structural organization and expression of the gene for the mouse GM2 activator protein
    C Bertoni
    Dipartimento di Biologia Cellulare e Molecolare, Universita di Perugia, Italy
    Mamm Genome 8:90-3. 1997
    ..Northern blot analysis demonstrated variation in the GM2 activator protein mRNA expression during mouse development. Gm2a was mapped to Chromosome (Chr) 11, where it co-segregated with Csfgm.
  53. ncbi IL-3 and granulocyte-macrophage colony-stimulating factor strongly induce Ig secretion by sort-purified murine B cell activated through the membrane Ig, but not the CD40, signaling pathway
    C M Snapper
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 154:5842-50. 1995
    ..We show that either IL-3 or granulocyte-macrophage CSF (GM-CSF) stimulates 10- to 50-fold enhancements in IgM secretion by sort-purified B cells treated with alpha delta-..
  54. ncbi Localization of sequences related to the human RAD6 DNA repair gene on mouse chromosomes 11 and 13
    M L Roller
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109-0618, USA
    Mamm Genome 6:305-6. 1995
  55. ncbi In vitro affinity maturation of human GM-CSF antibodies by targeted CDR-diversification
    Stefan Steidl
    MorphoSys AG, Lena Christ Str 48, Martinsried 82152, Germany
    Mol Immunol 46:135-44. 2008
    ..of antibodies specific for the pro-inflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) from the HuCAL GOLD human antibody library is described...
  56. ncbi Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction
    H Jiao
    Department of Cancer Biology, Cleveland Clinic Research Institute, OH 44195, USA
    Exp Hematol 25:592-600. 1997
    ..mice die from pulmonary accumulation of macrophages that are regulated by macrophage colony-stimulating factor (M-CSF) and granulocyte (G)-M-CSF...
  57. ncbi Molecular basis for developmental changes of GM-CSF gene inducibility in embryonal carcinoma cells
    T Heike
    Department of Pediatrics, Faculty of Medicine, Kyoto University, Japan
    Biochem Biophys Res Commun 198:473-9. 1994
    In a previous report, we reported that the induction of GM-CSF gene in differentiated P19 cells results from the maturation of the transcriptional machinery...
  58. ncbi IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic protein
    E U Sarmiento
    Department of Immunology Microbiology, Rush Medical College, Chicago, IL 60612, USA
    J Immunol 155:2211-21. 1995
    We have examined the potential of IL-3, IL-5, and granulocyte-macrophage (GM)-CSF to enhance basophil activation by eosinophil granule major basic protein (MBP). Preincubating basophil-containing mononuclear cells with 0...
  59. ncbi The transcription factor Sp1 is required for induction of the murine GM-CSF promoter in T cells
    E S Masuda
    Department of Cellular Biology, DNAX Research Institute, Palo Alto, CA 94304
    Biochem Biophys Res Commun 205:1518-25. 1994
    The cis-acting region, GM-kappa B/GC-box (positions -95 and -73), within the murine GM-CSF gene promoter is required for maximal induction by stimulation with phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) in T cells...
  60. ncbi Single proline substitutions in predicted alpha-helices of murine granulocyte-macrophage colony-stimulating factor result in a loss in bioactivity and altered glycosylation
    S W Altmann
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104
    J Biol Chem 266:5333-41. 1991
    ....
  61. ncbi Mapping the ovine genes encoding IL3, IL4, IL5, and CSF2 to sheep chromosome 5q13-q15 by FISH
    R J Hawken
    Centre for Animal Biotechnology, University of Melbourne, Parkville, Australia
    Mamm Genome 7:858-9. 1996
  62. ncbi A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human
    A M Buchberg
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genetics 122:153-61. 1989
    ..to mouse chromosome 11 by somatic cell hybrid or genetic backcross analysis were determined (Erbb, Rel, 11-3, Csfgm, Trp53-1, Evi-2, Erba, Erbb-2, Csfg, Myhs, Cola-1, Myla, Hox-2 and Pkca)...
  63. ncbi Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during development
    Y Chang
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032
    J Neuroimmunol 52:9-17. 1994
    ..Cytokines studied were interleukin (IL)-1 alpha, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, macrophage-colony stimulating factor (M-CSF), granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage-colony stimulating factor ..
  64. ncbi Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor
    R E Ploemacher
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Leukemia 7:1374-80. 1993
    ..The observed activity of IL-12, however, required the presence of a least two factors, i.e. either IL-3 + IL-11, or IL-3 + SF...
  65. ncbi Drugs elevating extracellular adenosine administered in vivo induce serum colony-stimulating activity and interleukin-6 in mice
    L Weiterova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Physiol Res 56:463-73. 2007
    ..AMP), enhances murine hematopoiesis and potentiates the action of granulocyte colony-stimulating factor (G-CSF)...
  66. ncbi T-cell nuclei contain a protein that binds upstream of the murine granulocyte-macrophage colony-stimulating factor gene
    R James
    Melbourne Tumor Biology Branch, Ludwig Institute for Cancer Research, Victoria, Australia
    Proc Natl Acad Sci U S A 86:7392-6. 1989
    ..A has been shown to cause a large increase in the cytoplasmic granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA level...
  67. ncbi Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis
    David M Higgins
    Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 180:4892-900. 2008
    Members of the CSF cytokine family play important roles in macrophage recruitment and activation. However, the role of M-CSF in pulmonary infection with Mycobacterium tuberculosis is not clear...
  68. ncbi Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity
    F Gouilleux
    Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany
    EMBO J 14:2005-13. 1995
    ..In the UT7 human hematopoietic cell line, EPO and granulocyte-macrophage colony stimulating factor activate the DNA binding activity of a factor closely related to MGF-Stat5 with respect to its ..
  69. ncbi GM-CSF-induced autoimmune gastritis in interferon alpha receptor deficient mice
    Judith Field
    Department of Medicine, Monash University, Clayton, Victoria 3168, Australia
    J Autoimmun 31:274-80. 2008
    ..responses, we asked whether EAG induced by the local transgenic expression of granulocyte-macrophage colony stimulating factor (GM-CSF) in the stomach (PC-GMCSF transgenic mice) would be affected by deficiency of its binding ..
  70. ncbi Localization of the human chromosome 5q genes Gabra-1, Gabrg-2, Il-4, Il-5, and Irf-1 on mouse chromosome 11
    M S Buckwalter
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109-0618
    Mamm Genome 3:604-7. 1992
  71. ncbi GM-CSF-facilitated dendritic cell recruitment and survival govern the intestinal mucosal response to a mouse enteric bacterial pathogen
    Yoshihiro Hirata
    Department of Medicine, University of California, San Diego, La Jolla, 92093 0623, USA
    Cell Host Microbe 7:151-63. 2010
    Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes dendritic cell (DC) differentiation and survival in vitro. However, its role in host defense at the intestinal mucosa is unknown...
  72. ncbi Stress response genes are suppressed in mouse preimplantation embryos by granulocyte-macrophage colony-stimulating factor (GM-CSF)
    Peck Y Chin
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA 5005, Australia
    Hum Reprod 24:2997-3009. 2009
    Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known to promote the development and survival of human and mouse preimplantation embryos; however, the mechanism of action of GM-CSF in embryos is not defined.
  73. ncbi The role of granulocyte macrophage-colony stimulating factor in gastrointestinal immunity to salmonellosis
    C Coon
    Discipline of Pathology, Bosch Institute, University of Sydney, New South Wales, Australia
    Scand J Immunol 70:106-15. 2009
    ..of human typhoid fever, with Salmonella typhimurium infection of wild type and granulocyte macrophage-colony stimulating factor (GM-CSF) knock out mice we show a delay in the onset of immune-mediated tissue damage in the spleens and ..
  74. ncbi The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury
    Ying Chen
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 28:10983-9. 2008
    ..Thus, our studies suggest that Olig2 is critical for postinjury gliosis...
  75. ncbi The IL-4 and IL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11
    J S Lee
    Medical Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra ACT
    Somat Cell Mol Genet 15:143-52. 1989
    ..Since the Il-5 locus maps to the interface of bands A5 and B1 in the same location as the genes for IL-3 and GM-CSF, this places these three cytokine genes, as well as the IL-4 gene, within a region of about 5000-10,000 kb...
  76. ncbi Changes in intracellular Ca2+ levels induced by cytokines and P2 agonists differentially modulate proliferation or commitment with macrophage differentiation in murine hematopoietic cells
    Edgar J Paredes-Gamero
    Department of Biophysics, Federal University of Sao Paulo, Rua Botucatu 862, 04023 062 Sao Paulo, Brazil
    J Biol Chem 283:31909-19. 2008
    ....
  77. ncbi Granulocyte macrophage colony stimulating factor produced in lesioned peripheral nerves induces the up-regulation of cell surface expression of MAC-2 by macrophages and Schwann cells
    A Saada
    Department of Anatomy and Embryology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Cell Biol 133:159-67. 1996
    ..lesion causes noneuronal cells, primarily fibroblasts, to produce the cytokine granulocyte macrophage-colony stimulating factor (GM-CSF)...
  78. ncbi Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor
    M A Cantrell
    Proc Natl Acad Sci U S A 82:6250-4. 1985
    Human granulocyte/macrophage colony-stimulating factor (GM-CSF) is a glycoprotein that is essential for the in vitro proliferation and differentiation of precursor cells into mature granulocytes and macrophages...
  79. ncbi Role of GM-CSF in tolerance induction by mobilized hematopoietic progenitors
    Hassen Kared
    Universite Paris Descartes, Faculte de Medecine, Centre National de la Recherche Scientifique UMR 8147, France
    Blood 112:2575-8. 2008
    ..Herein we identified one such soluble factor as granulocyte macrophage-colony stimulating factor (GM-CSF), which is produced at higher levels by HPCs than HSCs and whose neutralization significantly ..
  80. ncbi Secretion of stem cell factor and granulocyte-macrophage colony-stimulating factor by mouse embryos in culture: influence of group culture
    A P Contramaestre
    Universidad Simon Bolivar, Departamento de Biologia de Organismos, Baruta, Venezuela
    Zygote 16:297-301. 2008
    ..strain CD-1) to the blastocyst stage; (2) the release of granulocyte-macrophage colony-stimulating factor (GM-CSF) and stem cell factor (SCF) into the culture medium by the embryo; and (3) the levels of GM-CSF and SCF in the ..
  81. ncbi Synergistic effect of IL-3 and IL-6 on highly enriched murine hemopoietic progenitors
    S Okada
    Department of Medicine, Jichi Medical School, Tochigi ken, Japan
    Exp Hematol 20:546-51. 1992
    ..Therefore, it is concluded that IL-6 acts directly on hemopoietic stem cells to enhance their proliferation...
  82. ncbi Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region
    K A Frazer
    Human Genome Center, Lawrence Berkeley National Laboratory LBNL, Berkeley, California 94720, USA
    Genome Res 7:495-512. 1997
    ....
  83. ncbi Flt3 ligand synergizes with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice
    K Brasel
    Department of Immunobiology, Immunex Corporation, Seattle, WA 98101, USA
    Blood 90:3781-8. 1997
    ..human flt3 ligand (FL), alone and in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF ) or granulocyte colony-stimulating factor (G-CSF ), to mobilize colony forming cells (CFU) into the peripheral ..
  84. ncbi Characterization of ovarian function in granulocyte-macrophage colony-stimulating factor-deficient mice
    M J Jasper
    Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, The University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia
    Biol Reprod 62:704-13. 2000
    ..of this study was to investigate the physiological role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the ovary, utilizing mice genetically deficient in GM-CSF...
  85. ncbi Growth factor receptor expression during in vitro differentiation of partially purified populations containing murine stem cells
    E Ashihara
    Laboratory of Hematopoietic Growth Factors, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    J Cell Physiol 171:343-56. 1997
    ..or erythroid [SCF + IL-3 + erythropoietin (Epo)] or myeloid [SCF + IL-3 + granulocyte colony-stimulating factor (G-CSF)] differentiation...
  86. ncbi GM-CSF and IL-12 production by malignant plasma cells promotes cell-mediated immune responses against monoclonal Ig determinants in a light chain myeloma model
    H R Galea
    Laboratoire d Immunologie, CNRS UMR 6101, University Hospital, Limoges, France
    Clin Exp Immunol 129:247-53. 2002
    ..An expression plasmid encoding GM-CSF and IL-12 proved to be highly efficient for the induction of both cytotoxic and proliferative responses after ..
  87. ncbi Tpm1, a locus controlling IL-12 responsiveness, acts by a cell-autonomous mechanism
    M L Guler
    Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 162:1339-47. 1999
    ..This result strongly implies that despite the proximity of our locus to the IL-13/IL-4 gene cluster, these cytokines are not candidates for Tpm1...
  88. ncbi Developmental changes of GM-CSF gene inducibility in embryonal carcinoma cells
    T Heike
    Department of Pediatrics, Faculty of Medicine, Kyoto University, Japan
    Mol Immunol 31:1269-75. 1994
    ..development, failed to produce cytokines, such as interleukin-3 (IL-3), IL-4, granulocytemacrophage colony stimulating factor (GM-CSF) and interferon-beta (IFN-beta) at the mRNA level...
  89. ncbi GM-CSF secreted by murine adenocarcinoma cells modulates tumor progression and immune activity
    M J Diament
    Area Investigacion, Instituto de Oncología AH Roffo, 1417 Buenos Aires, Argentina
    Oncol Rep 10:1647-52. 2003
    ..M3 tumor cells secrete GM-CSF, which is able to promote in vitro proliferation of M3 cells as well as spleen cells...
  90. ncbi Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative mapping approach with human Chromosome 5q31-q33
    Maria Hernandez-Valladares
    International Livestock Research Institute ILRI, P O Box 30709, 00100, Nairobi, Kenya
    Immunogenetics 56:115-7. 2004
    ..Strikingly, several Th2 cytokines that are located within char8 have been identified to play a predominant role in the late stages of the infection...
  91. ncbi SP-D and GM-CSF regulate surfactant homeostasis via distinct mechanisms
    M Ikegami
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 281:L697-703. 2001
    Both surfactant protein (SP) D and granulocyte-macrophage colony-stimulating factor (GM-CSF) influence pulmonary surfactant homeostasis, with the deficiency of either protein causing marked accumulation of surfactant phospholipids in ..
  92. ncbi The structure and expression of the murine gene encoding granulocyte-macrophage colony stimulating factor: evidence for utilisation of alternative promoters
    E Stanley
    EMBO J 4:2569-73. 1985
    Two overlapping genomic clones containing the murine granulocyte-macrophage colony stimulating factor (GM-CSF) gene have been isolated...
  93. ncbi Haemopoiesis in mice genetically lacking granulocyte-macrophage colony stimulating factor during chronic infection with Mycobacterium avium
    Y Zhan
    Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 78:118-23. 2000
    In order to test the role of granulocyte-macrophage colony stimulating factor (GM-CSF) in haemopoiesis during chronic infection, mice with a targeted disruption of the gene for GM-CSF were infected intraperitoneally with the facultative ..
  94. ncbi Up- and down-regulation of granulocyte/macrophage-colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms
    A Mann
    Medical Department, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 61:2311-9. 2001
    The role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in tumorigenesis is complex. On the one hand, GM-CSF can promote tumor cell growth, survival, and even metastasis...
  95. ncbi Repression of Gadd45alpha by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation
    M Perugini
    Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, South Australia, Australia
    Leukemia 23:729-38. 2009
    ..constitutive signaling from two FLT3 mutants (FLT3-ITD and FLT3-TKD) commonly found in AML, and a leukemogenic GM-CSF receptor trans-membrane mutant (GMR-V449E). GADD45A mRNA downregulation is also associated with FLT3-ITD(+) AML...
  96. ncbi Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci
    N W Shworak
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 274:5170-84. 1999
    ..Moreover, the extensive number of 3OST genes with diverse expression patterns of multiple transcripts suggests that the novel 3-OST enzymes, like 3-OST-1, regulate important biologic properties of heparan sulfate proteoglycans...
  97. ncbi Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11
    S E Wenderfer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0524, USA
    Genomics 63:354-73. 2000
    ..4 (Il4), interleukin 5 (Il5), interleukin 13 (Il13), and granulocyte-macrophage colony-stimulating factor (Csfgm or Csf2), are tightly linked on mouse chromosome 11...
  98. ncbi Granulocyte-macrophage colony-stimulating factor in the innate immune response to Pneumocystis carinii pneumonia in mice
    R Paine
    Division of Pulmonary and Critical Care Medicine, University of Michigan, and Department of Veterans Affairs Medical Center, Ann Arbor, MI 48105, USA
    J Immunol 164:2602-9. 2000
    ..We investigated the role of GM-CSF in host defense in a model of P. carinii pneumonia induced by intratracheal inoculation of CD4-depleted mice...
  99. ncbi Mice lacking both granulocyte colony-stimulating factor (CSF) and granulocyte-macrophage CSF have impaired reproductive capacity, perturbed neonatal granulopoiesis, lung disease, amyloidosis, and reduced long-term survival
    J F Seymour
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Parkville, Victoria, Australia
    Blood 90:3037-49. 1997
    Mice lacking granulocyte colony-stimulating factor (G-CSF) are neutropenic with reduced hematopoietic progenitors in the bone marrow and spleen, whereas those lacking granulocyte-macrophage colony-stimulating factor (GM-CSF) have ..
  100. ncbi Genomic interval engineering of mice identifies a novel modulator of triglyceride production
    Y Zhu
    Genome Sciences Department, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 97:1137-42. 2000
    ....
  101. ncbi Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection
    Mercedes Gonzalez-Juarrero
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523, USA
    J Leukoc Biol 77:914-22. 2005
    Mice lacking expression of granulocyte macrophage-colony stimulating factor (GM-CSF KO) are unable to contain Mycobacterium tuberculosis (M. tuberculosis) growth and succumb to infection by 35 days following pulmonary challenge...

Research Grants60

  1. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 1993
    ..Thus, it may be possible to correlate the functional activity of T cells with their expression of specific T cell receptor family. Furthermore, HIS-62 and HIS-80 may serve as a paradigm for the interaction of Hc antigens with T cells...
  2. CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESIS
    Bethany Moore; Fiscal Year: 2002
    ..These studies should lead to new insights into the biology of prostate cancer growth and metastasis, and pave the way to adapt adjuvant therapies for the treatment of this widespread disease. ..
  3. Collectin Deficiency in the mouse
    Samuel Hawgood; Fiscal Year: 2004
    ..Although our studies are focused on a specific organism, we expect the mechanisms underlying collectin-IAV-host interactions will pertain more generally to the action of collectins in respiratory immune responses. ..
  4. PGE2 Regulation of Host Defense post-BMT
    Bethany Moore; Fiscal Year: 2009
    ..current studies will determine whether increased production of granulocyte-macrophage colony-stimulating factor (GM-CSF) post-BMT leads to increased production of PGE2 and whether the donor vs...
  5. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  6. GM-CSF is required for macrophage surfactant catabolism
    Tracey Bonfield; Fiscal Year: 2006
    ..The granulocyte macrophage-colony stimulating factor (GM-CSF) knockout mouse develops a PAP like syndrome, which can be resolved by pulmonary expression of ..
  7. PGE2 Regulation of Host Defense post-BMT
    Bethany Moore; Fiscal Year: 2007
    ..current studies will determine whether increased production of granulocyte-macrophage colony-stimulating factor (GM-CSF) post-BMT leads to increased production of PGE2 and whether the donor vs...
  8. Cytokine Dysregulation in GM-CSF Autoimmunity
    Mary Jane Thomassen; Fiscal Year: 2007
    ..recognized autoimmune disorder characterized by neutralizing autoantibodies to granulocyte-macrophage colony stimulating factor (GMCSF) and severely dysregulated lung surfactant metabolism, the GM-CSh requirement in normal ..
  9. NICHD Institutional Training for Pediatricians
    Samuel Hawgood; Fiscal Year: 2007
    ..abstract_text> ..
  10. Zeiss LSM 510 Laser Scanning Microscope
    Mercedes Gonzalez Juarrero; Fiscal Year: 2007
    ..The initial service contracts will derive from the guarantee of the machine and thereafter, users' feel will be responsible for the cost of the facility. ..
  11. PPARgamma Dysfunction in Sarcoidois
    Mary Jane Thomassen; Fiscal Year: 2005
    ..BAL and peripheral blood cells to challenge with positive (interleukin 4 [IL-4], granulocyte-macrophage colony stimulating factor [GM-CSF]), phorbol myristate acetate [PMA]); and negative (PPARgamma ligands, IFNgamma) regulators of ..
  12. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..months and sustaining its durability requires tumor necrosis factor (TNF)-c_ and granulocyte-macrophage colony stimulating factor (GM-CSF) but not interleukins-10 or -12 or interferon-¿...
  13. FASEB Summer Research Conference, Lung Surfactant: Molecular and Cell Biology
    Samuel Hawgood; Fiscal Year: 2006
    ..4. Molecular pathogenesis of human lung diseases associated with abnormal lung development of mutations in the surfactant proteins. 5. Collectins and mucosal host defense. 6. Design of novel surfactant-based therapeutics. ..
  14. PGE2 Regulation of Epithelial/Fibroblast Interactions
    Bethany Moore; Fiscal Year: 2006
    ..abstract_text> ..
  15. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2006
    ..and sustaining its durability requires tumor necrosis factor (TNF)-alpha and granulocyte-macrophage colony stimulating factor (GM-CSF) but not interleukins-10 or -12 or interferon-gamma...
  16. Fibrocyte Phenotypes as Biomarkers in IPFnet Patients
    Bethany B Moore; Fiscal Year: 2010
    ..Our proposed studies would be the first to provide longitudinal and cross sectional analyses of fibrocyte phenotypes as biomarkers in human fibrotic lung disease. (End of Abstract) ..
  17. Chemokine-Cytokine Nexus in Fungal Immunity
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for appropriate signaling through a surface receptor for a particular chemokine in order that the host can survive. ..
  18. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  19. PGE2 Regulation of Host Defense post-BMT
    Bethany B Moore; Fiscal Year: 2010
    ..current studies will determine whether increased production of granulocyte-macrophage colony-stimulating factor (GM-CSF) post-BMT leads to increased production of PGE2 and whether the donor vs...
  20. Immunopathogenesis in Histoplasmosis
    GEORGE DEEPE; Fiscal Year: 2009
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  21. PGE2 Regulation of Host Defense post-BMT
    Bethany Moore; Fiscal Year: 2009
    ..current studies will determine whether increased production of granulocyte-macrophage colony-stimulating factor (GM-CSF) post-BMT leads to increased production of PGE2 and whether the donor vs...
  22. Cytokine Signaling in Autoimmune APC Dysfunction
    Sally Litherland; Fiscal Year: 2005
    Both overexpression and knock-out deletion of granulocyte-macrophage colony stimulating factor (GM-CSF) in mice can lead to dysregulation of myeloid differentiation and autoimmune disease...
  23. STAT5 and PGS2 Dysfunction in Type 1 Diabetes
    Sally Litherland; Fiscal Year: 2005
    ..autoimmune PGS2/COX2 expression was highly resistant to IL-10 suppression, and that high autocrine production of GM-CSF by at-risk/Type1 diabetic human monocytes and non-obese diabetic (NOD) mouse macrophages promotes a build up of ..
  24. COLLECTIN DEFICIENCY
    Samuel Hawgood; Fiscal Year: 2000
    ....
  25. GM-CSF THERAPY FOR ALVEOLAR PROTEINOSIS
    Mary Jane Thomassen; Fiscal Year: 2003
    ..Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) deficient mice develop a PAP like syndrome which is corrected by exogenous GM-CSF, suggesting a ..
  26. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2002
    ....