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| MAG1SummaryGene Symbol: MAG1 Description: Mag1p Alias: MMS5 Species: Top Publications
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Publications
Cloning and expression in Escherichia coli of a gene for an alkylbase DNA glycosylase from Saccharomyces cerevisiae; a homologue to the bacterial alkA geneK G Berdal
Norwegian Defence Research Establishment, Division for Environmental Toxicology, Kjeller, Norway
EMBO J 9:4563-8. 1990..The yeast enzyme was able to excise 7-methylguanine as well as 3-methyladenine from dimethyl sulphate treated DNA, confirming the related nature of this enzyme to the AlkA DNA glycosylase from E. coli...- A role for yeast and human translesion synthesis DNA polymerases in promoting replication through 3-methyl adenineRobert E Johnson
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX 77555 1061, USA
Mol Cell Biol 27:7198-205. 2007..We discuss these results in the context of previous observations that have been made for the roles of Pols eta, iota, and kappa in promoting replication through the minor-groove N2-dG adducts... - Involvement of two endonuclease III homologs in the base excision repair pathway for the processing of DNA alkylation damage in Saccharomyces cerevisiaeMichelle Hanna
Department of Microbiology and Immunology, University of Saskatchewan, 107 Wiggins Road, SK, S7N 5E5, Saskatoon, Canada
DNA Repair (Amst) 3:51-9. 2004..a model DNA alkylating agent methyl methanesulfonate (MMS) and that this sensitivity can be reduced by deleting the MAG1 3-methyladenine DNA glycosylase gene... - Deletion of the MAG1 DNA glycosylase gene suppresses alkylation-induced killing and mutagenesis in yeast cells lacking AP endonucleasesW Xiao
Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E5
Mutat Res 487:137-47. 2001..Interestingly, this sensitivity can be reduced up to 2500-fold by deleting the MAG1 3-methyladenine DNA glycosylase gene, suggesting that Mag1 not only removes lethal base lesions, but also benign .. - Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damageJ Chen
Laboratory of Toxicology, Harvard School of Public Health, Boston, MA 02115
EMBO J 9:4569-75. 1990..0% identity and 63.5% similarity with the E. coli AlkA glycosylase. Transcription of the MAG gene, like that of the E. coli alkA gene, is greatly increased when yeast cells are exposed to relatively non-toxic levels of alkylating agents... - Synergism between yeast nucleotide and base excision repair pathways in the protection against DNA methylation damageW Xiao
Department of Microbiology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Canada S7N 5E5
Curr Genet 33:92-9. 1998..In the yeast Saccharomyces cerevisiae, the base excision repair pathway is initiated by a Mag1 3-methyladenine DNA glycosylase that removes the damaged base, followed by the Apn1 apurinic/apyrimidinic .. - The repair of DNA methylation damage in Saccharomyces cerevisiaeW Xiao
Department of Microbiology, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada
Curr Genet 30:461-8. 1996..An alkylation-specific base-excision repair pathway in yeast is initiated by a Mag1 3MeA DNA glycosylase that removes the damaged base, followed by an Apn1 apurinic/ apyrimidinic endonuclease that .. - The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1Wenjian Ma
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Mol Cell Biol 29:1212-21. 2009.... - Eukaryotic Y-family polymerases bypass a 3-methyl-2'-deoxyadenosine analog in vitro and methyl methanesulfonate-induced DNA damage in vivoBrian S Plosky
Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 3371, USA
Nucleic Acids Res 36:2152-62. 2008..To confirm the physiological relevance of our findings, we show that in S. cerevisiae lacking Mag1-dependent 3MeA repair, poleta (Rad30) contributes to the survival of cells exposed to methyl methanesulfonate (MMS) .. - Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysisWenjian Ma
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences NIH, DHHS, Research Triangle Park, NC 27709, USA
Nucleic Acids Res 36:1836-46. 2008..Monitoring BER in single and multiple glycosylase and AP-endonuclease mutants confirmed that Mag1 is the major enzyme that removes MMS-damaged bases... - Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agentPaola Monti
Department of Epidemiology and Prevention, National Cancer Research Institute IST, L go R Benzi, 10, 16132 Genova, Italy
DNA Repair (Amst) 7:431-8. 2008..Base excision repair (BER)-defective S. cerevisiae strains mag1 and apn1apn2 were both significantly more sensitive to Me-lex toxicity, but only the latter is significantly more .. - Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediatesIvan Rusyn
Center for Environmental Health Sciences and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
PLoS ONE 2:e1252. 2007..Taken together, these results suggest that a branch point exists in the current model for DNA damage-signaled transcription in S. cerevisiae... - Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeastSonja Flott
MRC Protein Phosphorylation Unit, James Black Centre, University of Dundee, Dundee DD1 5EH, United Kingdom
Mol Cell Biol 27:6433-45. 2007..These results indicate that Slx4 has multiple functions in responding to DNA damage and that a subset of these are regulated by Mec1/Tel1-dependent phosphorylation... - Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repairK Anke Schürer
Department of Molecular Genetics and Preparative Molecular Biology, Institute for Microbiology and Genetics, University of Gottingen, D 37077 Gottingen, Germany
Genetics 166:1673-86. 2004..On the contrary, in an sgs1 background we found a pronounced hyperrecombination phenotype. Thus, we propose that MPH1 is involved in a branch of homologous recombination that is specifically dedicated to error-free bypass... - The S. cerevisiae Mag1 3-methyladenine DNA glycosylase modulates susceptibility to homologous recombinationC A Hendricks
Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
DNA Repair (Amst) 1:645-59. 2002DNA glycosylases, such as the Mag1 3-methyladenine (3MeA) DNA glycosylase, initiate the base excision repair (BER) pathway by removing damaged bases to create abasic apurinic/apyrimidinic (AP) sites that are subsequently repaired by .. - Yeast RAD26, a homolog of the human CSB gene, functions independently of nucleotide excision repair and base excision repair in promoting transcription through damaged basesSung Keun Lee
Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, Texas 77555 1061, USA
Mol Cell Biol 22:4383-9. 2002..in yeast by the alternate competing pathways of base excision repair (BER), which is initiated by the action of MAG1-encoded N-methyl purine DNA glycosylase, and NER... - MMS1 protects against replication-dependent DNA damage in Saccharomyces cerevisiaeT Hryciw
Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada, S7K 0M7
Mol Genet Genomics 266:848-57. 2002..Together these results suggest a role for an Mms1-dependent, Rad52-mediated, pathway in protecting cells against replication-dependent DNA damage... - MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damageJ Scheller
Abteilung Molekulare Genetik und Präparative Molekularbiologie, Institut fur Mikrobiologie und Genetik, Georg August Universitat Gottingen, 37077 Gottingen, Germany
Genetics 155:1069-81. 2000..Epistasis analyses were carried out with representative mutants from various repair pathways (msh6, mag1, apn1, rad14, rad52, rad6, mms2, and rev3)... - The pol3-t hyperrecombination phenotype and DNA damage-induced recombination in Saccharomyces cerevisiae is RAD50 dependentAlvaro Galli
Laboratory of Gene and Molecular Therapy, Institute of Clinical Physiology, CNR, 56124 Pisa, Italy
J Biomed Biotechnol 2009:312710. 2009..Our results, however, show that the pol3-t mutation is synergistic for MMS sensitivity with MAG1, a known base excision repair gene, but it is epistatic with rad50Delta, suggesting that POL3 may be involved not .. - Cloning a eukaryotic DNA glycosylase repair gene by the suppression of a DNA repair defect in Escherichia coliJ Chen
Harvard School of Public Health, Charles A Dana Laboratory of Toxicology, Boston, MA 02115
Proc Natl Acad Sci U S A 86:7961-5. 1989..cerevisiae that carries a defect in the glycosylase gene and is extremely sensitive to DNA methylation. This approach may allow the isolation of a large number of eukaryotic DNA repair genes...