ZNF217

Summary

Gene Symbol: ZNF217
Description: zinc finger protein 217
Alias: ZABC1
Species: human

Top Publications

  1. ncbi Coordinated histone modifications mediated by a CtBP co-repressor complex
    Yujiang Shi
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 422:735-8. 2003
  2. ncbi Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence
    J J M Cowger
    Department of Oncology, London Regional Cancer Program, The University of Western Ontario, London, Ontario, Canada
    Oncogene 26:3378-86. 2007
  3. ncbi Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad
    Kate G R Quinlan
    School of Molecular and Microbial Biosciences, G08, University of Sydney, NSW 2006, Australia
    Biochim Biophys Acta 1775:333-40. 2007
  4. ncbi The ZNF217 oncogene is a candidate organizer of repressive histone modifiers
    Michaela S Banck
    Department of Medicine Hematology Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Epigenetics 4:100-6. 2009
  5. ncbi ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction
    Guiqing Huang
    Cancer Research Institute, The University of California San Francisco, CA 94143 0808, USA
    Hum Mol Genet 14:3219-25. 2005
  6. ncbi Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line
    Guiqin Sun
    Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, P R China
    Int J Oncol 32:1065-71. 2008
  7. ncbi Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins
    Kate G R Quinlan
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia
    Mol Cell Biol 26:8159-72. 2006
  8. ncbi The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells
    G H Nonet
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 61:1250-4. 2001
  9. ncbi Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma
    C Collins
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 95:8703-8. 1998
  10. ncbi Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex
    M Kuppuswamy
    Institute for Molecular Virology, Saint Louis University School of Medicine, Daisy Research Center, 1100 South Grand Blvd, St Louis, MO 63104, USA
    Mol Cell Biol 28:269-81. 2008

Research Grants

  1. Roles of CtBP in cancer and its mechanism of action
    Yujiang Shi; Fiscal Year: 2004
  2. Genomic Analysis of ER Negative Breast Cancer
    Donna Albertson; Fiscal Year: 2007
  3. Genomic and Functional Analysis of Oral Cancer Development
    Donna Albertson; Fiscal Year: 2007
  4. Microarray-Based Scanning of the Mouse Genome
    Donna Albertson; Fiscal Year: 2007
  5. High Resolution Genomic Analysis of Amplicon Structure
    Donna Albertson; Fiscal Year: 2006
  6. CaP Metastasis Biomarkers: Validation/Genomics/Biology
    Colin Collins; Fiscal Year: 2007
  7. High Resolution Genomic Analysis of Amplicon Structure
    Donna Albertson; Fiscal Year: 2007
  8. Genomic and Functional Analysis of Oral Cancer Development
    Donna Albertson; Fiscal Year: 2009
  9. Amplicons in Oral Dysplasia
    Donna Albertson; Fiscal Year: 2009
  10. Development of ESP: Structural & Functional Oncogenomics
    Colin Collins; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications63

  1. ncbi Coordinated histone modifications mediated by a CtBP co-repressor complex
    Yujiang Shi
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 422:735-8. 2003
    ..These findings identify a molecular mechanism by which CtBP mediates transcriptional repression and provide insight into CtBP participation in oncogenesis...
  2. ncbi Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence
    J J M Cowger
    Department of Oncology, London Regional Cancer Program, The University of Western Ontario, London, Ontario, Canada
    Oncogene 26:3378-86. 2007
    Zinc-finger protein 217 (ZNF217) is a Kruppel-like zinc-finger protein located at 20q13.2, within a region of recurrent maximal amplification...
  3. ncbi Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad
    Kate G R Quinlan
    School of Molecular and Microbial Biosciences, G08, University of Sydney, NSW 2006, Australia
    Biochim Biophys Acta 1775:333-40. 2007
    ..The amplification correlates with poor prognosis. Over-expression of the zinc-finger protein 217 (ZNF217), a candidate oncogene on 20q13...
  4. ncbi The ZNF217 oncogene is a candidate organizer of repressive histone modifiers
    Michaela S Banck
    Department of Medicine Hematology Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Epigenetics 4:100-6. 2009
    The zinc finger protein 217 (ZNF217) is an important oncogene based on the high frequency of amplification and overexpression in many cancer types, but its molecular mode of gene regulation is poorly understood...
  5. ncbi ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction
    Guiqing Huang
    Cancer Research Institute, The University of California San Francisco, CA 94143 0808, USA
    Hum Mol Genet 14:3219-25. 2005
    ..positional cloning and genomic sequencing culminated in a detailed molecular description of the candidate oncogene ZNF217. ZNF217 proteins resemble Kruppel-like transcription factors, localize predominately to the nucleus and associate ..
  6. ncbi Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line
    Guiqin Sun
    Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, P R China
    Int J Oncol 32:1065-71. 2008
    Zinc-finger protein 217 (ZNF217), a candidate oncogene on 20q13...
  7. ncbi Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins
    Kate G R Quinlan
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia
    Mol Cell Biol 26:8159-72. 2006
    ..We show that the large zinc finger protein ZNF217 contacts CtBP. ZNF217 is encoded by an oncogene frequently amplified in tumors...
  8. ncbi The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells
    G H Nonet
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 61:1250-4. 2001
    The functional consequences of overexpression of a candidate oncogene on chromosome 20q13.2, ZNF217, were examined by transducing the gene into finite life span human mammary epithelial cells (HMECs)...
  9. ncbi Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma
    C Collins
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 95:8703-8. 1998
    ..Analysis of the 1-Mb region produced evidence for five genes, ZNF217, ZNF218, and NABC1, PIC1L (PIC1-like), CYP24, and a pseudogene CRP (Cyclophillin Related Pseudogene)...
  10. ncbi Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex
    M Kuppuswamy
    Institute for Molecular Virology, Saint Louis University School of Medicine, Daisy Research Center, 1100 South Grand Blvd, St Louis, MO 63104, USA
    Mol Cell Biol 28:269-81. 2008
    ..We also provide evidence that CtBP1 functions as a platform for sumoylation of cofactors...
  11. ncbi Genes differentially expressed in human lung fibroblast cells transformed by glycidyl methacrylate
    Xue Jun Yin
    Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China
    Biomed Environ Sci 17:432-41. 2004
    ..To define the differences in gene expression patterns between glycidyl methacrylate (GMA)-transformed human lung fibroblast cells (2BS cells) and controls...
  12. ncbi Identification of a second CtBP binding site in adenovirus type 5 E1A conserved region 3
    Rachel K Bruton
    Cancer Research UK, Institute of Cancer Studies, University of Birmingham, Birmingham, United Kingdom
    J Virol 82:8476-86. 2008
    ..through a sequence ((161)RRNTGDP(167)) very similar to a recently characterized novel CtBP binding motif in ZNF217 as well as other regions of CR3...
  13. ncbi The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas
    Yu Sun
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada
    Int J Cancer 123:1761-9. 2008
    ..is the site of several oncogenes, including the eukaryotic elongation factor EEF1A2 and the transcription factor ZNF217. We reported previously that overexpressed ZNF217 induces neoplastic characteristics in precursor cells of OEC...
  14. ncbi Molecular genetic aberrations of ovarian and uterine carcinosarcomas--a CGH and FISH study
    Alexander Schipf
    Institute of Pathology, KSL Luzern, 6000 Luzern 16, Switzerland
    Virchows Arch 452:259-68. 2008
    ..FISH revealed c-myc (8q24.12) and ZNF217 (20q13.2) amplification in 78 and 87%...
  15. ncbi Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study
    Martin Widschwendter
    Department of Gynecological Oncology, UCL Institute for Women s Health, University College London, London, United Kingdom
    PLoS ONE 3:e2656. 2008
    ..However, whether DNA methylation in normal unrelated cells is associated with BC risk and whether these imprints can be related to factors which can be modified by the environment, is unclear...
  16. ncbi High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines
    Hong Zhu
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Cancer Lett 245:303-14. 2007
    ..Candidate tumour loci and encompassed genes at 7p21 (AGR2), 8q21(TPD52), 20q13 (ZNF217, WFDC2, EEF1A2) and 10p15 (KLF6) were analyzed by dual colour FISH for genomic changes and quantitative PCR for ..
  17. ncbi Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex
    Gobi Thillainadesan
    Department of Oncology, London Regional Cancer Program and The Lawson Health Research Institute, London, Ontario, Canada
    Mol Cell Biol 28:6066-77. 2008
    The ZNF217 oncoprotein is a constituent of a core transcriptional complex that includes CoREST, histone deacetylase 1/2, lysine demethylase 1, and the C-terminal binding protein 1/2...
  18. ncbi Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays
    Derek J Nancarrow
    Oncogenomics, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Cancer Res 68:4163-72. 2008
    ..Frequent gains were noted around MYC (13 of 23), BCL9 (12 of 23), CTAGE1 (14 of 23), and ZNF217 (12 of 23)...
  19. ncbi Comprehensive analysis of 20q13 genes in ovarian cancer identifies ADRM1 as amplification target
    Marlena S Fejzo
    Department of Medicine, Division of Hematology Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Genes Chromosomes Cancer 47:873-83. 2008
    ..narrowed the candidates to 19 genes that were consistently overexpressed in a subset of tumors amplified for both ZNF217 and TPD54, although, interestingly the candidates do not include these two amplified genes...
  20. ncbi [Expression of ZNF217 in human ovarian cystadenocarcinoma and its clinical significance]
    Gui Qin Sun
    Department of Obstetrics and Gynecology Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:685-8. 2009
    To explore the correlation of ZNF217 expression to the carcinogenesis and progression of human ovarian cancer.
  21. ncbi Analysis of gene status in cervical dysplastic lesions and squamous cell carcinoma using tissue microarrays
    Carlota Costa
    Pathology Department, Cytogenetic and Molecular Biology Laboratory, Citology Section, Mar Hospital, IMAS, Barcelona, Spain
    Histol Histopathol 24:821-9. 2009
    ..Eight genes and five proteins were examined in each samples (hTERT, PIK3CA, hTERC, MYC, CCND1, BCL2, ZNF217 and p16) by fluorescence in situ hybridization (FISH) and/or immunohistochemistry (IHC)...
  22. ncbi The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain
    Noelia Nunez
    School of Molecular Bioscience, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 286:38190-201. 2011
    ..We have examined the multi-finger protein ZNF217, which contains eight classical zinc fingers...
  23. ncbi Fluorescence in situ hybridization mapping of esophagectomy specimens from patients with Barrett's esophagus with high-grade dysplasia or adenocarcinoma
    Shannon M Brankley
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Hum Pathol 43:172-9. 2012
    ..2 (znf217)...
  24. ncbi Correlation between genomic alterations assessed by array comparative genomic hybridization, prognostically informative histologic subtype, stage, and patient survival in gastric cancer
    Elena Rossi
    Biology and Medical Genetics, University of Pavia, 27100 Pavia, Italy
    Hum Pathol 42:1937-45. 2011
    ..sporadic amplification of chromosome regions harboring important oncogenes like MYC, KRAS, NRAS, CRKL, CCNE1, or ZNF217. We conclude that genome-wide array comparative genomic hybridization of gastric cancer contributes prognostically ..
  25. ncbi Single nucleotide polymorphisms in the 20q13 amplicon genes in relation to breast cancer risk and clinical outcome
    Hong Shi
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Breast Cancer Res Treat 130:905-16. 2011
    ..Here, we investigated genetic variation in five 20q13 amplicon genes (MYBL2, AURKA, ZNF217, STK4 and PTPN1) and its impact on breast cancer (BC) susceptibility and clinical outcome...
  26. ncbi Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stem cells regulated by hypoxia-inducible factors
    Xing gang Mao
    Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Lab Invest 91:1068-78. 2011
    ..b>ZNF217 is an oncogene frequently amplified in many kinds of tumors...
  27. ncbi Microarray analysis of gene expression in the ovarian cancer cell line HO-8910 with silencing of the ZNF217 gene
    Guiqin Sun
    Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangdong, P R China
    Mol Med Report 2:851-5. 2009
    Zinc-finger protein 217 (ZNF217), which is overexpressed during cancer progression, can promote tumor cell immortalization...
  28. ncbi ZNF217 confers resistance to the pro-apoptotic signals of paclitaxel and aberrant expression of Aurora-A in breast cancer cells
    Aurélie Thollet
    Universite de Lyon, Lyon, France
    Mol Cancer 9:291. 2010
    b>ZNF217 is a candidate oncogene located at 20q13, a chromosomal region frequently amplified in breast cancers...
  29. ncbi ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells
    S R Krig
    Department of Biochemistry and Molecular Medicine, Divison of Basic Sciences, University of California at Davis Cancer Center, Sacramento, CA 95817, USA
    Oncogene 29:5500-10. 2010
    ..In this study we showed that the ZNF217 transcription factor, amplified at 20q13 in ?20% of breast tumors, regulates ErbB3 expression...
  30. ncbi CCND1 and ZNF217 gene amplification is equally frequent in BRCA1 and BRCA2 associated and non-BRCA breast cancer
    P Plevova
    Department of Medical Genetics, Faculty Hospital of Ostrava, Ostrava, Czech Republic
    Neoplasma 57:325-32. 2010
    ..We determined whether there was any difference in CCND1 (11q13) and ZNF217 (20q13) gene amplification with respect to BRCA status...
  31. ncbi DNA copy numbers profiles in affinity-purified ovarian clear cell carcinoma
    Kuan Ting Kuo
    Division of Gynecological Pathology, Departments of Pathology, Gynecology Obstetrics, and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 16:1997-2008. 2010
    ..The purpose of this study is to comprehensively define the genomic changes in CCC based on DNA copy number alterations...
  32. ncbi [Construction and expression of the eukaryotic green fluorescent protein expression vector pEGFP-N1-ZNF217]
    Jing Li
    Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:391-3. 2010
    To construct the eukaryotic green fluorescent protein expression vector pEGFP-N1-ZNF217 and express the vector in eukaryotic cells.
  33. ncbi Interaction of ZEB and histone deacetylase with the PLDLS-binding cleft region of monomeric C-terminal binding protein 2
    Ling Jun Zhao
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, St, Louis, Missouri 63104, USA
    BMC Mol Biol 10:89. 2009
    ..CtBP proteins function as dimers to mediate transcriptional repression and dimerization is modulated by specific binding to NAD/NADH...
  34. ncbi High resolution analysis of DNA copy-number aberrations of chromosomes 8, 13, and 20 in gastric cancers
    Tineke E Buffart
    Department of Pathology, VU University Medical Center, PO Box 7057, 1007, Amsterdam, The Netherlands
    Virchows Arch 455:213-23. 2009
    ..DNA copy-number gains of TNFRSF6B (20q13.3) and ZNF217 (20q13.2) were significantly associated with lymph node metastasis (p = 0.02) and histological type (p = 0...
  35. ncbi Coexistence of copy number increases of c-Myc, ZNF217, CCND1, ErbB1 and ErbB2 in ovarian cancers
    Ivanka Dimova
    Department of Medical Genetics, Medical University Sofia, Bulgaria
    Onkologie 32:405-10. 2009
    We selected 5 oncogenes with well-established roles in carcinogenesis -- CCND1, ErbB1, ErbB2, c-myc and ZNF217 -- to investigate the coexistence of their copy imbalances in relation to the clinico-pathological characteristics of ovarian ..
  36. ncbi BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain
    Anke H Sillars-Hardebol
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Pathol 226:442-50. 2012
    ..protein expression is regulated at the post-transcriptional level by a distinct factor on the 20q amplicon (eg ZNF217, AURKA or miRNAs)...
  37. ncbi Multiple roles of the candidate oncogene ZNF217 in ovarian epithelial neoplastic progression
    Peixiang Li
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada
    Int J Cancer 120:1863-73. 2007
    The transcription factor ZNF217 is often amplified in ovarian cancer, but its role in neoplastic progression is unknown...
  38. ncbi Comparative study between DNA copy number aberrations determined by quantitative microsatellite analysis and clinical outcome in patients with stomach cancer
    Seiji Suzuki
    Department of Surgery, Tama Nagayama Hospital, Nippon Medical School, Tama shi, Tokyo, Japan
    Clin Cancer Res 10:3013-9. 2004
    ..We additionally clarified the relationship between DNA copy number aberrations and the clinical outcome of the patients...
  39. ncbi Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization
    Marjan M Weiss
    Department of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands
    J Pathol 200:320-6. 2003
    ..In the present study, an amplicon at 20q13.2 has been narrowed down to 800 kb which is likely to harbour one or more putative oncogenes relevant to gastric carcinogenesis, for which ZNF217 and CYP24 are good candidates.
  40. ncbi A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes
    Mohamed Ali Hakimi
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:7234-9. 2003
    ..These findings not only delineate a novel class of multiprotein complexes involved in transcriptional repression but also reveal an unanticipated role for TFII-I in transcriptional repression...
  41. ncbi Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers
    Takafumi Watanabe
    Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Jpn J Cancer Res 93:1114-22. 2002
    ..2), TGIF2 (20q11.2), AIB1 (20q12), PTPN1 (20q13.1), ZNF217 (20q13.2), and BTAK (20q13), and then measured transcription levels of each candidate in 18 OC cell lines...
  42. ncbi Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas
    Xin Mao
    Skin Tumour Unit and Dermatopathology Department, St John s Institute of Dermatology, St Thomas Hospital, London, United Kingdom
    Blood 101:1513-9. 2003
    ..and BCR (22q11) in 4 cases (57%), and gains of MYCL1 (1p34), PIK3CA (3q26), HRAS (11p15), MYBL2 (20q13), and ZNF217 (20q13) in 3 cases (43%)...
  43. ncbi Spectrum of genetic changes in gastro-esophageal cancer cell lines determined by an integrated molecular cytogenetic approach
    Carla Rosenberg
    Laboratory of Cytochemistry and Cytometry, Department Molecular Cell Biology, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Cancer Genet Cytogenet 135:35-41. 2002
    ..The use of a commercially available genomic array excluded TOP2A (17q), and MYBL2, PTPT1, CSE1L, and ZNF217 (20q) as candidate genes for frequently amplified areas on these chromosomes, and contributed to refining the ..
  44. ncbi Comprehensive genome sequence analysis of a breast cancer amplicon
    C Collins
    University of California San Francisco Cancer Center, San Francisco, California 94143 0808, USA
    Genome Res 11:1034-42. 2001
    ..One of these, ZNF217, is capable of immortalizing human mammary epithelial cells (HMEC) when overexpressed...
  45. ncbi CoREST is an integral component of the CoREST- human histone deacetylase complex
    A You
    Department of Molecular and Cellular Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 98:1454-8. 2001
    ....
  46. ncbi Differences in 20q13.2 copy number between colorectal cancers with and without liver metastasis
    S Hidaka
    The First Department of Surgery, Nagasaki University School of Medicine, Nagasaki City, Japan
    Clin Cancer Res 6:2712-7. 2000
    ..We investigated the copy number of the 20q13.2 region including the ZNF217 oncogene in 17 nonmetastatic colorectal cancers (CRCs), 18 primary CRC tumors with liver metastasis, and 18 ..
  47. ncbi Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene
    D G Albertson
    1 Cancer Research Institute, University of California, San Francisco, Box 0808, San Francisco, California, USA
    Nat Genet 25:144-6. 2000
    ..2 in breast cancer. The putative oncogene ZNF217 (ref...
  48. ncbi Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer
    M M Tanner
    Laboratory of Cancer Genetics, Institute of Medical Technology, Tampere University and University Hospital, Finland
    Clin Cancer Res 6:1833-9. 2000
    ..Of the genes amplified in breast cancer, the BTAK gene was amplified in 21%, the MYBL2 gene in 17%, and the ZNF217 gene in 12.5% of the sporadic tumors. The high frequency of gene amplification at 20q12-q13...
  49. ncbi Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells
    Tarlochan Nijjar
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Oncogene 24:3369-76. 2005
    ..HMEC immortalized by a variety of agents (the chemical carcinogen benzo(a)pyrene, oncogenes c-myc and ZNF217, and/or dominant negative p53 genetic suppressor element GSE22) displayed marked upregulation (10-15 fold) of the ..
  50. ncbi Detection of Her2/neu, c-MYC and ZNF217 gene amplification during breast cancer progression using fluorescence in situ hybridization
    Masayuki Shimada
    Department of Technology Development and Assessment, IDV, SRL Inc, 5 6 50 Shinmachi, Hino shi, Tokyo 191 0002, Japan
    Oncol Rep 13:633-41. 2005
    ..The amplification of Her2/neu or ZNF217 is closely associated with the stages of breast cancer...
  51. ncbi Amplification and overexpression of aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells
    C M Chung
    Cancer Biology Laboratory, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Mol Carcinog 43:165-74. 2005
    ..The chromosome 20q harbors genes including TGIF2 (20q11.2-q12), AIB1 (20q12), PTPN1 (20q13.1), ZNF217 (20q13.2), and AURKA (20q13.2-q13...
  52. ncbi Identification of genes directly regulated by the oncogene ZNF217 using chromatin immunoprecipitation (ChIP)-chip assays
    Sheryl R Krig
    Department of Pharmacology and the Genome Center, University of California, Davis, California 95616, USA
    J Biol Chem 282:9703-12. 2007
    It has been proposed that ZNF217, which is amplified at 20q13 in various tumors, plays a key role during neoplastic transformation...
  53. ncbi Gene-specific fluorescence in-situ hybridization analysis on tissue microarray to refine the region of chromosome 20q amplification in melanoma
    Denitsa K Koynova
    Department of Medical Genetics, Medical University, Sofia, Bulgaria
    Melanoma Res 17:37-41. 2007
    ..or even in melanoma progression from these regions, we combined fluorescence in-situ hybridization with MYBL2, ZNF217, CYP24 and STK6 specific probes (chromosomal region 20q13.1-q13...
  54. ncbi [ZNF217 gene was detected in ovarian serous cystadenocarcinoma by fluorescence in situ hybridization]
    Mei Zhong
    Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:665-7. 2006
    To investigate amplification of zinc finger protein 217 (ZNF217) gene in ovarian serous cystadenocarcinoma and its clinical significance.
  55. ncbi Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas
    Silke Lassmann
    Institut fur Pathologie, Universitatsklinikum Freiburg, Breisacherstr 115a, 79110, Freiburg, Germany
    J Mol Med (Berl) 85:293-304. 2007
    ..tumors and included DNA amplifications of eight genes on chromosome 20q (TOP1, AIB1, MYBL2, CAS, PTPN1, STK15, ZNF217, and CYP24), two genes on chromosome 13q (BRCA2 and D13S25), and three genes on chromosome 7 (IL6, CYLN2, and MET) ..
  56. ncbi Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers
    Anne Letessier
    Centre de Recherche en Cancerologie de Marseille, Département d Oncologie Moléculaire, UMR599 Inserm Institut Paoli Calmettes, Marseille, France
    BMC Cancer 6:245. 2006
    ..Amplification status may provide diagnostic and prognostic information and may lead to new treatment strategies. Chromosomal regions 8p12, 8q24, 11q13, 17q12 and 20q13 are recurrently amplified in breast cancers...
  57. ncbi [Oncogene ZNF217 amplification on chromosome 20 q in ovarian serous cystadenocarcinoma and its clinical implications]
    Jing Li
    Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:824-5. 2006
    To investigate the amplification of zinc finger protein 217 (ZNF217) gene on chromosome 20 in ovarian cancer and its clinical significance.
  58. ncbi Genomic array and expression analysis of frequent high-level amplifications in adenocarcinomas of the gastro-esophageal junction
    Herman van Dekken
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    Cancer Genet Cytogenet 166:157-62. 2006
    ..The HLA on 7q21 was associated recurrently with ABCB1, whereas the amplified region on 20q13 implicated ZNF217, BCAS1, and CYP24...
  59. ncbi [Study on amplification of ZNF217 in primary gastric carcinoma]
    Ya qing Zhu
    Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Wei Chang Wai Ke Za Zhi 8:60-2. 2005
    To investigate amplification of zinc finger protein 217(ZNF217) and its association with clinicopathologic parameters in primary gastric carcinoma.
  60. ncbi Regulation of LSD1 histone demethylase activity by its associated factors
    Yu Jiang Shi
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Mol Cell 19:857-64. 2005
    ..Taken together, these findings suggest that LSD1-mediated histone demethylation is regulated dynamically in vivo. This is expected to have profound effects on gene expression under both physiological and pathological conditions...
  61. ncbi An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
    Min Gyu Lee
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nature 437:432-5. 2005
    ..Together, these results highlight an essential role for CoREST in demethylation of H3K4 both in vitro and in vivo...
  62. ncbi Coexistence of copy number changes of different genes (INK4A, erbB-1, erbB-2, CMYC, CCND1 and ZNF217) in urothelial tumors
    D Toncheva
    Department of Medical Genetics, Medical Faculty Sofia, Sofia, Bulgaria
    Tumour Biol 26:88-93. 2005
    ..and separate copy number changes of INK4A (9p21), erbB-1 (7p11), erbB-2 (17q17-21), CMYC (8q24), CCND1 (11q13) and ZNF217 (20q13) in urothelial tumors; a tissue microarray of 159 urothelial bladder tumors was analyzed by fluorescence in ..
  63. ncbi Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization
    A Kallioniemi
    Department of Biomedical Sciences, University of Tampere, Finland
    Proc Natl Acad Sci U S A 91:2156-60. 1994
    ..Chromosomal regions with increased copy-number often spanned tens of Mb, suggesting involvement of more than one gene in each region...

Research Grants36

  1. Roles of CtBP in cancer and its mechanism of action
    Yujiang Shi; Fiscal Year: 2004
    ..3) Characterize a new zinc finger protein ZNF217 in the CtBP complex to reveal the molecular basis for its implied role in breast cancers.
  2. Genomic Analysis of ER Negative Breast Cancer
    Donna Albertson; Fiscal Year: 2007
    ..In addition, these studies will determine which mouse models most closely resemble different subtypes of ER negative tumors at the molecular level, thereby enhancing their utility as preclinical models. ..
  3. Genomic and Functional Analysis of Oral Cancer Development
    Donna Albertson; Fiscal Year: 2007
    ..The most fundamental way to make progress toward improving diagnosis and treatment of oral cancer is to elucidate the specific genes and the interactions among genes that become abnormal as cancer develops. ..
  4. Microarray-Based Scanning of the Mouse Genome
    Donna Albertson; Fiscal Year: 2007
    ..New approaches for hybridization and analysis will be developed to extend the dynamic range of the expression measurements so we can obtain data from mRNAs expressed at very low abundances. ..
  5. High Resolution Genomic Analysis of Amplicon Structure
    Donna Albertson; Fiscal Year: 2006
    ..abstract_text> ..
  6. CaP Metastasis Biomarkers: Validation/Genomics/Biology
    Colin Collins; Fiscal Year: 2007
    ..von Eschenbach. ..
  7. High Resolution Genomic Analysis of Amplicon Structure
    Donna Albertson; Fiscal Year: 2007
    ..abstract_text> ..
  8. Genomic and Functional Analysis of Oral Cancer Development
    Donna Albertson; Fiscal Year: 2009
    ..The most fundamental way to make progress toward improving diagnosis and treatment of oral cancer is to elucidate the specific genes and the interactions among genes that become abnormal as cancer develops. ..
  9. Amplicons in Oral Dysplasia
    Donna Albertson; Fiscal Year: 2009
    ..The most fundamental way to make progress toward improving diagnosis and treatment of oral cancer is to elucidate the specific genes and the interactions among genes that become abnormal as cancer develops. ..
  10. Development of ESP: Structural & Functional Oncogenomics
    Colin Collins; Fiscal Year: 2005
    ..abstract_text> ..
  11. INDENTIFICATION OF ONCOGENES ON 20Q
    Donna Albertson; Fiscal Year: 1999
  12. VPR-INDUCED ENDOTHELIAL CYTOSKELETAL/FUNCTIONAL CHANGES
    Ling Jun Zhao; Fiscal Year: 2002
    ..We anticipate that this project will generate novel knowledge about the mechanism of Vpr induced cytoskeletal/functional changes in endothelial cells that can benefit the designing of therapeutic strategies. ..
  13. Amplicon Profiling by Array CGH
    Donna Albertson; Fiscal Year: 2004
    ..abstract_text> ..
  14. Amplicons in Oral Dysplasia
    Donna G Albertson; Fiscal Year: 2010
    ..The most fundamental way to make progress toward improving diagnosis and treatment of oral cancer is to elucidate the specific genes and the interactions among genes that become abnormal as cancer develops. ..