YWHAZ

Summary

Gene Symbol: YWHAZ
Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Alias: 14-3-3-zeta, KCIP-1, YWHAD, 14-3-3 delta, 14-3-3 protein zeta/delta, 14-3-3 protein/cytosolic phospholipase A2, 14-3-3 zeta, phospholipase A2, protein kinase C inhibitor protein 1, protein kinase C inhibitor protein-1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide, tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide
Species: human

Top Publications

  1. ncbi 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition
    Jing Lu
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 16:195-207. 2009
  2. ncbi Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1
    Hung Kai Chen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 113:457-68. 2003
  3. ncbi Selective association of protein kinase C with 14-3-3 zeta in neuronally differentiated PC12 Cells. Stimulatory and inhibitory effect of 14-3-3 zeta in vivo
    Laura Gannon-Murakami
    Department of Biology, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 277:23116-22. 2002
  4. ncbi Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
    Cynthia LeBron
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    EMBO J 25:1196-206. 2006
  5. ncbi Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding
    David W Powell
    Departments of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, USA
    Mol Cell Biol 23:5376-87. 2003
  6. ncbi Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting
    G Rena
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 354:605-12. 2001
  7. ncbi 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin
    Antje Gohla
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 12:1704-10. 2002
  8. ncbi The structural basis for 14-3-3:phosphopeptide binding specificity
    M B Yaffe
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cell 91:961-71. 1997
  9. ncbi Identification of 14-3-3zeta as an EGF receptor interacting protein
    Morten P Oksvold
    Institute of Pathology, Rikshospitalet University Hospital, University of Oslo, N 0027 Oslo, Norway
    FEBS Lett 569:207-10. 2004
  10. ncbi Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways
    C M Cahill
    Diabetes Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 276:13402-10. 2001

Research Grants

  1. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2009
  2. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2007
  3. LIPID MEDIATORS OF SIGNAL TRANSDUCTION IN SMOOTH MUSCLE
    Richard Gross; Fiscal Year: 2000
  4. CYTOSOLIC PHOSPHOLIPASE A2 TRANSFORMED CELLS
    Raphael Nemenoff; Fiscal Year: 2002
  5. Amyloid Induced Proinflam. Pathways /Cerebrovasculature
    Michael Mullan; Fiscal Year: 2003
  6. PHYSIOLOGIC/PATHOPHYSIOLOGIC REGULATION OF PHOSPHOLIPIDS
    Raphael Nemenoff; Fiscal Year: 1993
  7. PHOSPHOLIPASE A2 AND VASCULAR WALL REMODELING
    GADIPARTHI RAO; Fiscal Year: 2007
  8. REGULATION OF PHOSPHOLIPASE A2 NUCLEAR TARGETING
    Christina Leslie; Fiscal Year: 2003
  9. Regulation and Function of Cytosolic Phospholipase A2
    Michael Gelb; Fiscal Year: 2007
  10. LEUKOTRIENES AND MESSENGERS IN PHOTORECEPTOR RENEWAL
    Nicolas Bazan; Fiscal Year: 1993

Detail Information

Publications206 found, 100 shown here

  1. ncbi 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition
    Jing Lu
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 16:195-207. 2009
    ..Importantly, patients whose breast tumors overexpressed both ErbB2 and 14-3-3zeta had higher rates of metastatic recurrence and death than those whose tumors overexpressed only one...
  2. ncbi Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1
    Hung Kai Chen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 113:457-68. 2003
    ..Our finding that phosphatidylinositol 3-kinase/Akt signaling and 14-3-3 cooperate to modulate the neurotoxicity of ataxin-1 provides insight into SCA1 pathogenesis and identifies potential targets for therapeutic intervention...
  3. ncbi Selective association of protein kinase C with 14-3-3 zeta in neuronally differentiated PC12 Cells. Stimulatory and inhibitory effect of 14-3-3 zeta in vivo
    Laura Gannon-Murakami
    Department of Biology, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 277:23116-22. 2002
    ..Our results show that the association with 14-3-3 zeta has distinct effects on classical PKC and non-classical PKC activity...
  4. ncbi Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
    Cynthia LeBron
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    EMBO J 25:1196-206. 2006
    ..These results suggest that MDMX-14-3-3 interaction plays a role in p53 response to DNA damage by regulating MDMX localization and stability...
  5. ncbi Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding
    David W Powell
    Departments of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, USA
    Mol Cell Biol 23:5376-87. 2003
    ..These data suggest that MAPKAPK2-mediated phosphorylation regulates 14-3-3zeta functions, and this MAPKAPK2 activity may represent a novel pathway mediating p38 MAPK-dependent inflammation...
  6. ncbi Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting
    G Rena
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 354:605-12. 2001
    ....
  7. ncbi 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin
    Antje Gohla
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 12:1704-10. 2002
    ..Taken together, these results suggest that 14-3-3zeta proteins may play a dynamic role in the regulation of cellular actin structures through the maintenance of phosphocofilin levels...
  8. ncbi The structural basis for 14-3-3:phosphopeptide binding specificity
    M B Yaffe
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cell 91:961-71. 1997
    ..Finally, we show that the 14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl...
  9. ncbi Identification of 14-3-3zeta as an EGF receptor interacting protein
    Morten P Oksvold
    Institute of Pathology, Rikshospitalet University Hospital, University of Oslo, N 0027 Oslo, Norway
    FEBS Lett 569:207-10. 2004
    ..Our finding adds to the growing complexity of EGF receptor signaling and indicates a role for 14-3-3 proteins in EGF receptor signaling or regulation...
  10. ncbi Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways
    C M Cahill
    Diabetes Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 276:13402-10. 2001
    ..Thus, our results demonstrate at least two mechanisms, one 14-3-3-dependent and the other 14-3-3-independent, whereby PI 3-kinase signaling regulates DAF-16 DNA binding and transcription function...
  11. ncbi The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration
    Massimo M Santoro
    Department of Medical Sciences, University of Piemonte Orientale A Avogadro, 28100, Novara, Italy
    Dev Cell 5:257-71. 2003
    ....
  12. ncbi Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta
    Jörg Birkenfeld
    Department of Neurochemistry, Max Planck Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt, Germany
    Biochem J 369:45-54. 2003
    ..Our data are consistent with 14-3-3-protein-induced changes to the actin cytoskeleton resulting from interactions with cofilin and/or LIMK1...
  13. ncbi Spreading depression induces expression of calcium-independent protein kinase C subspecies in ischaemia-sensitive cortical layers: regulation by N-methyl-D-aspartate receptors and glucocorticoids
    S Koponen
    A.I. Virtanen Institute, University of Kuopio, Finland
    Neuroscience 93:985-93. 1999
    ..Quinacrine, a phospholipase A2 inhibitor, reduced only protein kinase C5 induction...
  14. ncbi The role of phosphatidylglycerol as a functional effector and membrane anchor of the D1-core peptide from photosystem II-particles of the cyanobacterium Oscillatoria chalybea
    O Kruse
    , , , Bundesrepublik Deutschland
    Z Naturforsch C 50:380-90. 1995
    ..In these experiments purified photosystem II (PSII)-particle preparations were treated with the enzyme phospholipase A2 and supplemented with lipid emulsions...
  15. ncbi Therapeutic time-window of a group IIA phospholipase A2 inhibitor in rabbit acute lung injury: correlation with lung surfactant protection
    S Furue
    Discovery Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    Crit Care Med 29:719-27. 2001
    OBJECTIVE: We attempted to determine whether group IIA secretory phospholipase A2 (sPLA2-IIA) blockade after the onset of lung injury exerted therapeutic efficacy in the treatment of oleic acid (OA)-induced acute lung injury by using S-..
  16. ncbi Differential changes of adrenoceptor- and muscarinic receptor-linked prostacyclin synthesis by the aorta and urinary bladder of the diabetic rat
    J Y Jeremy
    Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, University of London
    Br J Pharmacol 108:1131-6. 1993
    ..PKC]), Ca2+ ionophore A23187 (A23187) and thapsigargin (both elevate intracellular Ca2+, activating phospholipase A2 [PLA2]) and arachidonate (AA; substrate for PGI2 synthesis). 2...
  17. ncbi On radiation damage to normal tissues and its treatment. II. Anti-inflammatory drugs
    A S Michalowski
    MRC Cyclotron Unit, Hammersmith Hospital, London, UK
    Acta Oncol 33:139-57. 1994
    ..Glucocorticoids inhibit eicosanoid synthesis primarily by interfering with phospholipase A2 whilst non-steroidal anti-inflammatory drugs prevent prostaglandin/thromboxane synthesis by inhibiting ..
  18. ncbi 14-3-3 proteins within the hypothalamic-neurohypophyseal system of the osmotically stressed rat: transcriptomic and proteomic studies
    S S Gouraud
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
    J Neuroendocrinol 19:913-22. 2007
    ..Microarray studies on mRNAs differentially expressed in the SON revealed that transcripts encoding the Ywhag and Ywhaz isoforms of the 14-3-3 family of regulatory proteins, are increased in the rat SON by 3 days of water deprivation; ..
  19. ncbi Autocrine enhancement of leukotriene synthesis by endogenous leukotriene B4 and platelet-activating factor in human neutrophils
    P P McDonald
    Centre de Recherche en Inflammation, Immunologie et Rhumatologie, Institut de recherche du CHUL, Ste Foy, , Canada
    Br J Pharmacol 111:852-60. 1994
    ..PAF and LTB4 have the ability to positively feedback on LT synthesis by acting at the level of the phospholipase A2/re-esterification component of the LT biosynthetic pathway in neutrophils...
  20. ncbi Effect of propranolol and IFN-beta on the induction of MHC class II expression and cytokine production by IFN-gamma IN THP-1 human monocytic cells
    Q Li
    Department of Neurology, Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    Immunopharmacol Immunotoxicol 20:39-61. 1998
    ..TNF-alpha secretion, but may be necessary for IFN-gamma-mediated MHC class II induction and IL-1 beta production in human monocytes, whereas phospholipase A2 may not be required for IFN-gamma activation of PKC in the process.
  21. ncbi Pathomechanism of pain-related behavior produced by allografts of intervertebral disc in the rat
    M Kawakami
    Department of Orthopedic Surgery, Wakayama Medical College, Japan
    Spine (Phila Pa 1976) 21:2101-7. 1996
    ..it has been shown that hyperalgesia (an increased sensitivity to painful stimuli) involves activation of phospholipase A2 and nitric oxide synthase...
  22. ncbi Signal transduction in esophageal and LES circular muscle contraction
    K M Harnett
    Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
    Yale J Biol Med 72:153-68. 1999
    ..phospholipase C (PC-PLC), phospholipase D (PLD), and the high molecular weight (85 kDa) cytosolic phospholipase A2 (cPLA2) to induce phosphatidylcholine (PC) metabolism, production of diacylglycerol (DAG) and arachidonic ..
  23. ncbi Phospholipase A2-mediated superoxide production of murine peritoneal macrophages induced by chrysotile stimulation
    T Nakajima
    Division of Environmental Health Research, Osaka Prefectural Institute of Public Health, 69 3, 1 chome, 537 0025, Osaka, Japan
    Int J Biochem Cell Biol 32:779-87. 2000
    ....
  24. ncbi [Role of prostaglandins in the mechanism of action of indapamide]
    B Delbarre
    , Tours
    Arch Mal Coeur Vaiss 83:1209-12. 1990
    ..p.). Indapamide (3 mg/kg i.p.) induces significant decrease on BP over 60 min. Mepacrine (5 mg/kg i.p.), phospholipase A2 inhibitor, indomethacin (5 mg/kg i.p), cyclo-oxygenase inhibitor, and tranylcypromine (0,1 mg/kg i.p...
  25. ncbi Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carrageenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2
    A Miyake
    Molecular and Cellular Pharmacology, Dept, Yamanouchi Pharmaceutical Co Ltd, Tokyo, Japan
    Br J Pharmacol 110:447-53. 1993
    ..eny l) chroman] dose-dependently inhibited the activities of extracellular phospholipase A2 (PLA2): rabbit platelet-derived group II and porcine pancreas-derived group I PLA2, with IC50 values of 0...
  26. ncbi Involvement of B2 receptors in the bradykinin-induced relaxation of guinea-pig isolated trachea
    A da Silva
    Laboratoire de Neuroimmunopharmacologie, INSERM U405, , , Illkirch, France
    Br J Pharmacol 114:103-8. 1995
    ..In concentration-response curves, melittin (10 nM-1 microM), a direct activator of phospholipase A2, mimicked both effects of bradykinin...
  27. ncbi 14-3-3 sigma and 14-3-3 zeta plays an opposite role in cell growth inhibition mediated by transforming growth factor-beta 1
    Hye Young Hong
    Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, 200 701, Korea
    Mol Cells 29:305-9. 2010
    ..Taken together, our findings indicate that dysregulation of 14-3-3 sigma or 14-3-3 zeta contributes to TGF-beta1 resistance in cancer cells...
  28. ncbi Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures
    Niamh Murphy
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland, UK
    J Neurochem 106:978-88. 2008
    ..The present data indicate a role for 14-3-3 zeta in survival responses following ER stress and possibly protection against seizure injury to the hippocampus...
  29. ncbi Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells
    K L Suen
    Department of Molecular Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000, USA
    Oncogene 11:825-31. 1995
    ..These observations argue against a critical regulatory role of the 14-3-3 proteins in the Raf mitogenic pathway...
  30. ncbi Stimulation of yeast adenylyl cyclase activity by lysophospholipids and fatty acids. Implications for the regulation of Ras/effector function by lipids
    R J Resnick
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853
    J Biol Chem 269:32336-41. 1994
    ..These data suggest that lysophospholipids and fatty acids, metabolites of the mitogenically responsive enzyme phospholipase A2, may represent a novel mechanism for modulating the activity of downstream effector molecules and their ..
  31. ncbi Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI
    D W Snyder
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 288:1117-24. 1999
    ..This agent is currently undergoing clinical evaluation and should help to define the role of sPLA2 in various inflammatory disease states...
  32. ncbi The mechanism of action of alpha 2-adrenoceptors in human isolated subcutaneous resistance arteries
    N A Parkinson
    Department of Clinical Pharmacology, St Mary s Hospital Medical School, Imperial College of Science Technology and Medicine, London
    Br J Pharmacol 115:1463-8. 1995
    ..ETYA, an inhibitor of phospholipase A2, lipoxygenase and cyclo-oxygenase, had no effect on azepexole-induced contraction in the presence of N omega ..
  33. ncbi The role of phospholipase A2 and nitric oxide in pain-related behavior produced by an allograft of intervertebral disc material to the sciatic nerve of the rat
    M Kawakami
    Department of Orthopedic Surgery, Wakayama Medical College, Japan
    Spine (Phila Pa 1976) 22:1074-9. 1997
    ..applied to the sciatic nerve produces hyperalgesia, and if the hyperalgesia in influenced by inhibitors of phospholipase A2 and nitric oxide synthase...
  34. ncbi Cytosolic phospholipase A2: a member of the signalling pathway of a new G protein alpha subunit in Sporothrix schenckii
    Shirley Valentin-Berrios
    Department of Microbiology, San Juan Bautista School of Medicine, Caguas, PR 00726 4968
    BMC Microbiol 9:100. 2009
    ..Identifying these G proteins in fungi and their involvement in protein-protein interactions will help determine their role in signal transduction pathways...
  35. ncbi Prostaglandin production after experimental discectomy
    J T Robertson
    Department of Neurosurgery, University of Tennessee, Memphis, USA
    Spine (Phila Pa 1976) 21:1731-6. 1996
    ..have shown that nuclear material obtained from degenerative discs manifests an extraordinarily high level of phospholipase A2 activity...
  36. ncbi Pancreatic phospholipase A2 induces bacterial translocation in rats
    H Hongo
    First Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    Immunopharmacol Immunotoxicol 21:717-26. 1999
    The importance of pancreatic enzymes, particularly phospholipase A2 (PLA2), for bacterial translocation, which is considered to be one of the aggravating causes of acute pancreatitis, was investigated...
  37. ncbi Effect of retinoic acid on prostaglandin F2 alpha-induced prostaglandin E2 synthesis in osteoblast-like cells
    O Kozawa
    Department of Biochemistry, Institute for Developmental Research, Aichi Prefectural Colony, Japan
    Horm Metab Res 26:374-8. 1994
    ..However, RA had little effect on PGE2 synthesis induced by melittin, known as a phospholipase A2 activator. Moreover, pertussis toxin had little effect on arachidonic acid release induced by PGF2 alpha...
  38. ncbi Intracerebral injection of phospholipase A2 inhibits dopamine-mediated behavior in rats: possible implications for schizophrenia
    J Brunner
    Neurobiology Unit, Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 246:13-6. 1995
    b>Phospholipase A2 (PLA2) is a key enzyme in the phospholipid metabolism. In the CNS intracellular PLA2 plays an essential role in signal transduction by affecting both dopamine (DA) release and DA-receptor sensitivity...
  39. ncbi Phospholipase A2-induced electrophysiologic and histologic changes in rabbit dorsal lumbar spine tissues
    A C Ozaktay
    Wayne State University, Bioengineering Center, Detroit, Michigan, USA
    Spine (Phila Pa 1976) 20:2659-68. 1995
    STUDY DESIGN: The present study was designed to characterize the effect of phospholipase A2 on the discharge of perispinal sensory nerves in the anesthetized New Zealand white rabbit...
  40. ncbi Phospholipase A2 sensitivity of the dorsal root and dorsal root ganglion
    A C Ozaktay
    Wayne State University, Bioengineering Center, Detroit Michigan, USA
    Spine (Phila Pa 1976) 23:1297-306. 1998
    STUDY DESIGN: This study was designed to characterize the effects of phospholipase A2 on the neural response of dorsal root and dorsal root ganglion in the anesthetized New Zealand White rabbit...
  41. ncbi Purification of a new, calcium-independent, high molecular weight phospholipase A2/lysophospholipase (phospholipase B) from guinea pig intestinal brush-border membrane
    A Gassama-Diagne
    Institut National de la Santé et de la Recherche Médicale Unité 101, Biochimie des Lipides, Toulouse, France
    J Biol Chem 264:9470-5. 1989
    A phospholipase A2 activity directed against phosphatidylcholine was previously described in brush-border membrane from guinea pig intestine (Diagne, A., Mitjavila, S., Fauvel, J., Chap, H., and Douste-Blazy, L. (1987) Lipids 22, 33-40)...
  42. ncbi Inhibitory effect of MY-1250 on histamine release from rat peritoneal mast cells and guinea pig lung fragments: the elucidation of the mechanism
    C Kamei
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Immunopharmacol Immunotoxicol 13:341-56. 1991
    ..No significant changes were effected by MY-1250 in alpha-chymotrypsin activity and phospholipase A2 activity. Also, no antagonistic effects on LTD4 and PAF were observed.
  43. ncbi High levels of inflammatory phospholipase A2 activity in lumbar disc herniations
    J S Saal
    San Francisco Spine Institute, Seton Medical Center, Daly City, California
    Spine (Phila Pa 1976) 15:674-8. 1990
    ..The purpose of this study was to demonstrate whether an enzymatic marker for inflammation (phospholipase A2) could be identified in human disc samples removed at surgery for radiculopathy due to lumbar disc disease...
  44. ncbi Sensitivity of anulus fibrosus cells to interleukin 1 beta. Comparison with articular chondrocytes
    F Rannou
    , , , Paris, France
    Spine (Phila Pa 1976) 25:17-23. 2000
    ..from rabbits were grown in primary culture 1) to study their ability to produce prostaglandin E2 and Type II phospholipase A2, and to express stromelysin-1 messenger ribonucleic acid; and 2) to study the effect of interleukin 1 beta on ..
  45. ncbi Permissive stimulation of Ca(2+)-induced phospholipase A2 by an adenosine receptor agonist in a pertussis toxin-sensitive manner in FRTL-5 thyroid cells: a new 'cross-talk' mechanism in Ca2+ signalling
    S Shimegi
    Department of Physical Biochemistry, Gunma University, Maebashi, Japan
    Biochem J 299:845-51. 1994
    ..was associated with lysophosphatidylcholine production, and conclude that arachidonic acid is produced by phospholipase A2 in FRTL-5 thyroid cells...
  46. ncbi Affinity purification of phospholipase A2 on immobilized artificial membranes containing and lacking the glycerol backbone
    C Bernal
    Department of Medicinal Chemistry, School of Pharmacy, Perdue University, West Lafayette, IN 47907, USA
    J Chromatogr A 731:139-51. 1996
    ..of PLA2 on these IAM surfaces demonstrated that the surface structural differences were not important for phospholipase A2 (PLA2) binding...
  47. ncbi Immunocytochemical localization of immunoglobulins in disc herniations
    A Habtemariam
    First Department of Surgery, Helsinki University Central Hospital, Finland
    Spine (Phila Pa 1976) 21:1864-9. 1996
    ..SUMMARY OF BACKGROUND DATA: In herniated disc tissue, high activity of inflammatory phospholipase A2 was previously demonstrated, and inflammatory cells were noted immunohistochemically...
  48. ncbi Decreased phospholipase A2 activity in the brain and in platelets of patients with Alzheimer's disease
    W F Gattaz
    Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 246:129-31. 1996
    b>Phospholipase A2 (PLA2) is a key enzyme in the metabolism of membrane phospholipids...
  49. ncbi The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase
    Xiaoyong Lei
    Department of Medicine, Mass Spectrometry Resource, and Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 46:10170-85. 2007
    ..cells due to thapsigargin-induced ER stress was suppressed by inhibition of the group VIA Ca2+-independent phospholipase A2 (iPLA2beta), associated with an increased level of ceramide generation, and that the effects of ER stress ..
  50. ncbi Inhibition of carrageenin-induced rat paw oedema by crotapotin, a polypeptide complexed with phospholipase A2
    E C Landucci
    Department of Biochemistry, UNICAMP, Campinas SP, Brazil
    Br J Pharmacol 114:578-83. 1995
    1. The effect of purified crotapotin, a non-toxic non-enzymatic chaperon protein normally complexed to a phospholipase A2 (PLA2) in South America rattlesnake venom, was studied in the acute inflammatory response induced by carrageenin (1 ..
  51. ncbi Further characterization of a novel phospholipase B (phospholipase A2--lysophospholipase) from intestinal brush-border membranes
    S Pind
    Department of Biochemistry, University of Toronto, Ont, Canada
    Biochem Cell Biol 69:346-57. 1991
    ..membranes of rats and guinea pigs possess a high molecular weight, calcium-independent phospholipase B (phospholipase A2 - lysophospholipase activities) with the characteristics of a digestive ectoenzyme...
  52. ncbi Effect of neuroleptics on phospholipase A2 activity in the brain of rats
    H I Trzeciak
    Department of Pharmacology, Silesian Academy of Medicine, Katowice-Ligota, Poland
    Eur Arch Psychiatry Clin Neurosci 245:179-82. 1995
    The effect of neuroleptics on phospholipase A2 (PLA2) activity in rat brain plasma membranes was studied...
  53. ncbi Characterization of phospholipase A2 and acyltransferase activities in squid (Loligo pealei) axoplasm: comparison with enzyme activities in other neural tissues, axolemma and axoplasmic subfractions
    M Alberghina
    Institute of Biochemistry, Faculty of Medicine, University of Catania, Italy
    Neurochem Int 21:563-71. 1992
    b>Phospholipase A2 and acyltransferase were assayed and characterized in pure axoplasm and neural tissues of squid...
  54. ncbi Chymopapain-induced reduction of proinflammatory phospholipase A2 activity and amelioration of neuropathic behavioral changes in an in vivo model of acute sciatica
    P D Sawin
    Department of Pathology, The University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    J Neurosurg 86:998-1006. 1997
    ..the authors assessed the ability of chymopapain to modulate the activity of the proinflammatory enzyme phospholipase A2 (PLA2) and to ameliorate behavioral changes associated with inflammatory neuropathy in an in vivo model of ..
  55. ncbi Distinct phospholipase A2 enzymes regulate prostaglandin E2 and F2alpha production by bovine endometrial epithelial cells
    Patricia K Tithof
    The University of Tennessee College of Veterinary Medicine, TN, USA
    Reprod Biol Endocrinol 5:16. 2007
    The rate-limiting step in prostaglandin (PG) biosynthesis is catalyzed by phospholipase A2 (PLA2) enzymes which hydrolyze arachidonic acid from membrane phospholipids...
  56. ncbi Relation between accumulation of phospholipase A2 reaction products and Ca2+ release in isolated liver mitochondria
    I Rustenbeck
    Institute of Pharmacology and Toxicology, University of Gottingen, Germany
    Biochim Biophys Acta 1304:129-38. 1996
    A Ca(2+)-dependent stimulation of mitochondrial phospholipase A2 is often assumed to play a role in mitochondrial Ca2+ release...
  57. ncbi Calcium/calmodulin-dependent protein kinase IIalpha mediates activation of mitogen-activated protein kinase and cytosolic phospholipase A2 in norepinephrine-induced arachidonic acid release in rabbit aortic smooth muscle cells
    M M Muthalif
    Department of Pharmacology, College of Medicine, The University of Tennessee Center for Health Sciences, Memphis, Tennessee 38163, USA
    J Biol Chem 271:30149-57. 1996
    ..NE enhanced release of AA via activation of cytosolic phospholipase A2 (cPLA2) but not secretory PLA2 in VSMC prelabeled with [3H]AA...
  58. ncbi Human secretory phospholipase A2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice
    Uwe J F Tietge
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Arterioscler Thromb Vasc Biol 22:1213-8. 2002
    ..Secretory phospholipase A2 (sPLA2), an acute-phase protein, may play a key role in the pathophysiology of this phenomenon.
  59. ncbi Influence of epithelium on the inhibition of melittin-induced contraction of guinea-pig isolated trachea by the potassium channel opener NIP-121
    K Shikada
    Shiraoka Research Station of Biological Science, Nissan Chemical Industries, Ltd, Saitama, Japan
    Br J Pharmacol 109:1091-6. 1993
    ..have investigated the effect of the potassium channel opener, NIP-121, on contraction elicited by melittin (a phospholipase A2 activator) in epithelium-intact and epithelium-denuded trachea isolated from guinea-pigs...
  60. ncbi Phospholipase A2 activity-dependent stimulation of Ca2+ entry by human parvovirus B19 capsid protein VP1
    Adrian Lupescu
    Physiologisches Institut, der Universität Tübingen, Gmelinstr 5, D 72076 Tubingen, Germany
    J Virol 80:11370-80. 2006
    ..A secreted phospholipase A2 (PLA2)-like activity has been located in the VP1 unique region of the B19 minor capsid protein...
  61. ncbi Effect of a new inhibitor of type II phospholipase A2 on experimental acute pancreatitis in rats
    T Yoshikawa
    Department of Internal Medicine II, Nagoya University School of Medicine, Japan
    Pancreas 19:193-8. 1999
    The catalytic activity of type II phospholipase A2 (PLA2) in blood has been reported to increase in acute pancreatitis and to reflect the severity of pancreatitis...
  62. ncbi Effects of phospholipase A2 on lumbar nerve root structure and function
    C Chen
    Bioengineering Center, Wayne State University, Detroit, Michigan, USA
    Spine (Phila Pa 1976) 22:1057-64. 1997
    STUDY DESIGN: To investigate the effects of phospholipase A2 on the neurophysiology and histology of rat lumbar spinal nerves and the corresponding behavioral changes. OBJECTIVES: To study possible mechanisms of sciatica...
  63. ncbi Ca2+-independent phospholipase A2 contributes to the insulinotropic action of cholecystokinin-8 in rat islets: dissociation from the mechanism of carbachol
    E Simonsson
    Department of Medicine, Lund University, Malmo, Sweden
    Diabetes 47:1436-43. 1998
    Insulin secretion induced by cholecystokinin-8 (CCK-8) was recently suggested to involve phospholipase A2 (PLA2) activation...
  64. ncbi Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2
    E C Landucci
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil
    Toxicon 38:199-208. 2000
    The effects of crotapotin (a non-toxic and non-enzymatic acid polypeptide naturally complexed with phospholipase A2) and heparin on rat paw edema induced by different secretory phospholipases A2 (sPLA2) have been investigated...
  65. ncbi The role of steroids and their effects on phospholipase A2. An animal model of radiculopathy
    H M Lee
    Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, Korea
    Spine (Phila Pa 1976) 23:1191-6. 1998
    STUDY DESIGN: The possible role of phospholipase A2 in an animal model for lumbar radiculopathy and mechanisms of epidural steroid injections were studied...
  66. ncbi The role of inflammation in lumbar pain
    J S Saal
    SOAR, Physiatry Medical Group, Menlo Park, California, USA
    Spine (Phila Pa 1976) 20:1821-7. 1995
    ..The identification of high levels of an inflammatory enzyme, phospholipase A2, in lumbar herniated and degenerative discs presents the basis for a direct inflammogenic capability of ..
  67. ncbi Experimental Helicobacter felis infection in transgenic mice expressing human group IIA phospholipase A2
    Heikki T Huhtinen
    Department of Surgery, University of Turku and Turku University Central Hospital, Turku, Finland
    Helicobacter 9:408-16. 2004
    ..felis. C57BL/6 J mouse strain that lacks the expression of group IIA phospholipase A2 has been shown to develop more severe gastric inflammation than other mouse strains...
  68. ncbi Progesterone primes zona pellucida-induced activation of phospholipase A2 during acrosomal exocytosis in guinea pig spermatozoa
    Qi Xian Shi
    Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, People s Republic of China
    J Cell Physiol 205:344-54. 2005
    We investigated, using guinea-pig spermatozoa as a model, whether phospholipase A2 (PLA2) is involved in progesterone or zona pellucida (ZP)-stimulated acrosomal exocytosis, if progesterone enhances ZP-induced activation of PLA2, and ..
  69. ncbi Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin production
    James D Godkin
    Department of Animal Science, The University of Tennessee, Knoxville, TN, USA
    Reprod Biol Endocrinol 6:44. 2008
    ..b>Phospholipase A2 (PLA2) catalyzes the release of arachidonic acid from membrane phospholipids, the rate-limiting step in PG ..
  70. ncbi Resolution of isotoxins in the beta-bungarotoxin family
    C C Chu
    Institute of Biochemical Sciences, College of Science, National Taiwan University, Taipei
    J Chromatogr A 694:492-7. 1995
    ..Results of protein sequencing for P8, P9 and P11, the three main isotoxins, confirmed that they shared a common phospholipase A2 subunit, which was very similar to although not completely identical with the A1 chain reported previously.
  71. ncbi Mast cell degranulation induced by two phospholipase A2 homologues: dissociation between enzymatic and biological activities
    E C Landucci
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas SP, Brazil
    Eur J Pharmacol 343:257-63. 1998
    Bothropstoxin-I and bothropstoxin-II are phospholipase A2 homologues isolated from Bothrops jararacussu snake venom. The former is devoid of phospholipase A2 activity whereas the latter has very low enzymatic activity...
  72. ncbi Graves' immunoglobulins activate phospholipase A2 by recognizing specific epitopes on thyrotropin receptor
    A Di Cerbo
    Division and Research Unit of Endocrinology, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza General Hospital, San Giovanni Rotondo Foggia, Italy
    J Clin Endocrinol Metab 84:3283-92. 1999
    ..IgG from Graves' patients bind to the TSH receptor and activate both adenylyl cyclase (AC) and phospholipase A2 (PLA2) in FRTL5 thyroid cells...
  73. ncbi Determinants and mechanisms of human immune responses to bee venom phospholipase A2
    K Blaser
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 117:1-10. 1998
    ..Bee venom phospholipase A2 (PLA) represents the major antigen/allergen of honey bee venom...
  74. ncbi Identification of the neuronal acceptor in bovine cortex for ammodytoxin C, a presynaptically neurotoxic phospholipase A2
    I Krizaj
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Ljubljana, Slovenia
    Biochemistry 33:13938-45. 1994
    ..Vipera berus berus phospholipase A2 was a weaker inhibitor; nontoxic phospholipase A2, ammodytin I2, and the myotoxic phospholipase A2 homologue, ..
  75. ncbi Porcine pancreatic phospholipase A2 stimulates secretin release from secretin-producing cells
    T M Chang
    Konar Center for Digestive and Liver Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 274:10758-64. 1999
    ..14-kDa proteins with secretin-releasing activity that had N-terminal sequence homology with canine pancreatic phospholipase A2 (PLA2)...
  76. ncbi Rosmarinic acid, a new snake venom phospholipase A2 inhibitor from Cordia verbenacea (Boraginaceae): antiserum action potentiation and molecular interaction
    Fabio K Ticli
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, FCFRP, Universidade de Sao Paulo, USP, Ribeirao Preto SP, Brazil
    Toxicon 46:318-27. 2005
    ..Cv) significantly inhibited paw edema induced by Bothrops jararacussu snake venom and by its main basic phospholipase A2 homologs, namely bothropstoxins I and II (BthTXs)...
  77. ncbi Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor
    N G Ahn
    Department of Medicine, University of Washington, Seattle 98195
    J Biol Chem 263:18657-63. 1988
    Five proteins from human placenta capable of inhibiting pancreatic phospholipase A2 were purified. Two of these proteins were identified as lipocortins I and II...
  78. ncbi A new inhibitor of synovial phospholipase A2 from fermentations of Penicillium sp. 62-92
    L Witter
    Lehrbereich Biotechnologie, , Germany
    Z Naturforsch C 53:60-4. 1998
    ..62-92. Both compounds preferentially inhibited human synovial phospholipase A2, penidiamide with an IC50 of 30 microM and oxindole of 380 microM...
  79. ncbi Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom
    D O Toyama
    Centro de Cidncias Biológicas e da Saúde, Univesidade Mackenzie, Sao Paulo, Brazil
    Toxicon 53:417-26. 2009
    ..Although their controlling effect on serine proteases is well acknowledged, their action on secretory phospholipase A2 (sPLA2) remains obscure...
  80. ncbi Differences in the acute actions of sGnRH and cGnRH-II on gonadotropin release in goldfish pituitary cells
    J P Chang
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    Gen Comp Endocrinol 100:339-54. 1995
    ..In cell column perifusion experiments, treatment with inhibitors of phospholipase A2 (50 microM quinacrine or 50 microM bromophenacylbromide) or the lipoxygenase enzyme (50 microM ..
  81. ncbi PTH and phospholipase A2 in the aging process of intestinal cells
    Claudia Gentili
    Departamento de Biologia, Bioquimica and Farmacia, Universidad Nacional del Sur, 8000 Bahia Blanca, Argentina
    J Cell Biochem 93:312-26. 2004
    In this study we analyzed, for the first time, alterations in phospholipase A2 (PLA2) activity and response to parathyroid hormone (PTH) in rat enterocytes with aging...
  82. ncbi Impact of Phospholipase A2 group IIa gene polymorphism on phenotypic features of patients with familial adenomatous polyposis
    Ritsuko Yanaru-Fujisawa
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka, Japan
    Dis Colon Rectum 50:223-31. 2007
    b>Phospholipase A2 Group IIa has been suggested to be a possible disease modifier gene in familial adenomatous polyposis...
  83. ncbi Phospholipase A2 degradation products modulate epithelial and stromal 5alpha-reductase activity of human benign prostatic hyperplasia in vitro
    Heike Weisser
    Institute of Clinical Chemistry, Transfusion and Laboratory Medicine, University Clinic Bergmannsheil, Bochum, Germany
    Prostate 50:4-14. 2002
    ..Among those phospholipases, phospholipase A2 cleaves one of the acyl chains from phospholipids, thereby producing fatty acids and lysophospholipids such ..
  84. ncbi Binding of quinacrine to acidic phospholipids and pancreatic phospholipase A2. Effects on the catalytic activity of the enzyme
    P Mustonen
    Institute of Biomedicine, Department of Medical Chemistry, University of Helsinki, Finland
    Biochemistry 37:12051-7. 1998
    Binding of quinacrine to phospholipids and porcine pancreatic phospholipase A2 (PLA2) was investigated using fluorescence resonance energy transfer, Langmuir films, assay for the enzymatic activity, and molecular modeling...
  85. ncbi Role of an aprotinin-sensitive protease in protein kinase Calpha-mediated activation of cytosolic phospholipase A2 by calcium ionophore (A23187) in pulmonary endothelium
    Sajal Chakraborti
    Department of Biochemistry and Biophysics, University of Kalyani, Kalyani 741235, West Bengal, India
    Cell Signal 16:751-62. 2004
    ..cells with the calcium ionophore, A23187, stimulates the cell membrane associated protease activity, phospholipase A2 (PLA2) activity, and arachidonic acid (AA) release from the cells...
  86. ncbi Cytosolic phospholipase A2 Group IValpha but not secreted phospholipase A2 Group IIA, V, or X induces interleukin-8 and cyclooxygenase-2 gene and protein expression through peroxisome proliferator-activated receptors gamma 1 and 2 in human lung cells
    Rafal Pawliczak
    Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:48550-61. 2004
    ..We have shown previously that cytosolic phospholipase A2 (cPLA2) is able to activate gene expression through PPAR-gamma response elements (Pawliczak, R., Han, C...
  87. ncbi The role of lipoprotein-associated phospholipase A2 in atherosclerosis may depend on its lipoprotein carrier in plasma
    Constantinos C Tellis
    Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
    Biochim Biophys Acta 1791:327-38. 2009
    Platelet-activating factor (PAF) acetylhydrolase exhibits a Ca(2+)-independent phospholipase A2 activity and degrades PAFas well as oxidized phospholipids (oxPL)...
  88. ncbi Lipoprotein-associated phospholipase A2 for early risk stratification in patients with suspected acute coronary syndrome: a multi-marker approach: the North Wuerttemberg and Berlin Infarction Study-II (NOBIS-II)
    M Mockel
    Dept of Cardiology, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Clin Res Cardiol 96:604-12. 2007
    ..of the present study was to define the role of the emerging cardiovascular risk marker lipoprotein-associated phospholipase A2 (Lp-PLA2) in a multi-marker approach in combination with troponin I (TnI), NT-proBNP, high sensitivity (hs)..
  89. ncbi Competitive, reversible inhibition of cytosolic phospholipase A2 at the lipid-water interface by choline derivatives that partially partition into the phospholipid bilayer
    J R Burke
    Drug Discovery Research, Bristol Myers Squibb Pharmaceutical Research Institute, Buffalo, New York 14213, USA
    J Biol Chem 274:18864-71. 1999
    Cytosolic phospholipase A2 (cPLA2) catalyzes the selective release of arachidonic acid from the sn-2 position of phospholipids and is believed to play a key cellular role in the generation of arachidonic acid...
  90. ncbi Effects of scalaradial, a novel inhibitor of 14 kDa phospholipase A2, on human neutrophil function
    M S Barnette
    Department of Inflammation and Respiratory Pharmacology, SmithKline Beecham Laboratories, King of Prussia, PA 19406
    Biochem Pharmacol 47:1661-7. 1994
    ..natural product with anti-inflammatory activity, has been shown to be a selective inhibitor of 14 kDa type II phospholipase A2(PLA2). We have examined the inhibition by scalaradial (0...
  91. ncbi Cloning of the cDNA coding for 14 kDa group II phospholipase A2 from rat liver
    R H van Schaik
    Centre for Biomembranes and Lipid Enzymology, Utrecht University, The Netherlands
    Biochim Biophys Acta 1169:1-11. 1993
    The amino acid sequence of rat liver phospholipase A2 was partially elucidated using peptide fragments generated by enzymatic or chemical cleavage...
  92. ncbi Human disc phospholipase A2 is inflammatory
    R C Franson
    Virginia Commonwealth University, Department of Biochemistry and Molecular Biophysics, Richmond
    Spine (Phila Pa 1976) 17:S129-32. 1992
    Human discs have been demonstrated to contain high levels of phospholipase A2. As the enzyme responsible for the liberation of arachidonic acid from membranes, this enzyme has a theoretical inflammatory potential...
  93. ncbi Inhibition of inflammatory responses by epitaondiol and other marine natural products
    B Gil
    Department of Pharmacology, University of Valencia, Spain
    Life Sci 57:PL25-30. 1995
    ..This compound and epitaondiol decreased the release of eicosanoids with a higher potency on the cyclo-oxygenase pathway. Only epitaondiol inhibited human recombinant synovial phospholipase A2 activity in a concentration-dependent manner.
  94. ncbi Binding of human phospholipase A2 type II to proteoglycans. Differential effect of glycosaminoglycans on enzyme activity
    P Sartipy
    Wallenberg Laboratory for Cardiovascular Research, Department of Heart and Lung Disease, Goteborg University, Sahlgrenska University Hospital, S 413 45 Gothenburg, Sweden
    J Biol Chem 271:26307-14. 1996
    b>Phospholipase A2 acting on low density lipoproteins in the extracellular arterial intima may form proinflammatory lipid mediators...
  95. ncbi Phospholipase A2 inhibitors protect against prion and Abeta mediated synapse degeneration
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, AL9 7TA, UK
    Mol Neurodegener 5:13. 2010
    ..A pharmacological approach was used to screen cell signalling pathways involved in synapse degeneration...
  96. ncbi Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes
    M G de Carvalho
    Division of Basic Science, Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA
    J Biol Chem 271:6987-97. 1996
    The phosphorylation sites on the human, 85-kDa cytosolic phospholipase A2 (cPLA2) were identified using recombinant cPLA2 expressed in Spodoptera frugiperda (Sf9) cells...
  97. ncbi Restoration of on-time embryo implantation corrects the timing of parturition in cytosolic phospholipase A2 group IVA deficient mice
    Naoko Brown
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Biol Reprod 81:1131-8. 2009
    Cytosolic phospholipase A2 (cPLA2, PLA2G4A) catalyzes the release of arachidonic acid for prostaglandin synthesis by cyclooxygenase 1 (PTGS1) and cyclooxygenase 2 (PTGS2)...
  98. ncbi Inventing an arsenal: adaptive evolution and neofunctionalization of snake venom phospholipase A2 genes
    Vincent J Lynch
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06511, USA
    BMC Evol Biol 7:2. 2007
    ..Convincing examples of neofunctionalization, however, remain rare. Snake venom phospholipase A2 genes are members of large multigene families with many diverse functions, thus they are excellent models to ..

Research Grants96

  1. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2009
    ..abstract_text> ..
  2. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2007
    ..abstract_text> ..
  3. LIPID MEDIATORS OF SIGNAL TRANSDUCTION IN SMOOTH MUSCLE
    Richard Gross; Fiscal Year: 2000
    ..of agonist-induced release of arachidonic acid in vascular smooth cells is due to a calcium-independent phospholipase A2 which is regulated by ATP and calmodulin...
  4. CYTOSOLIC PHOSPHOLIPASE A2 TRANSFORMED CELLS
    Raphael Nemenoff; Fiscal Year: 2002
    ..b>Phospholipase A2 (PLA2), which hydrolyzes the sn-2 bond of membrane phospholipids, is the enzyme controlling arachidonic acid ..
  5. Amyloid Induced Proinflam. Pathways /Cerebrovasculature
    Michael Mullan; Fiscal Year: 2003
    ..peptides stimulate a pro-inflammatory pathway (sPLA2-MAPK-cPLA2-AA-LOX/COX) involving activation of secretory phospholipase A2 (PLA2), mitogen-activated protein kinase (MAPK) kinase (MEKI/2), p38 MAPK, cytosolic PLA2 (cPLA2), and the ..
  6. PHYSIOLOGIC/PATHOPHYSIOLOGIC REGULATION OF PHOSPHOLIPIDS
    Raphael Nemenoff; Fiscal Year: 1993
    ..b>Phospholipase A2 (PLA2), which hydrolyzes the sn-2 bond of membrane phospholipids, is the enzyme controlling arachidonic acid ..
  7. PHOSPHOLIPASE A2 AND VASCULAR WALL REMODELING
    GADIPARTHI RAO; Fiscal Year: 2007
    ..Such knowledge will be useful in the development of potential therapeutics targeting inflammatory vascular diseases such as atherosclerosis and restenosis. ..
  8. REGULATION OF PHOSPHOLIPASE A2 NUCLEAR TARGETING
    Christina Leslie; Fiscal Year: 2003
    Cytosolic phospholipase A2 (cPLA2) is a key regulatory enzyme that mediates agonist-induced arachidonic acid release...
  9. Regulation and Function of Cytosolic Phospholipase A2
    Michael Gelb; Fiscal Year: 2007
    ..Over the past decade several lines of evidence have appeared to indicate that the 85-kDa group IVA cytosolic phospholipase A2 (cPLA2-alpha) is critical for arachidonic acid release in agonist-stimulated pro-inflammatory cells including ..
  10. LEUKOTRIENES AND MESSENGERS IN PHOTORECEPTOR RENEWAL
    Nicolas Bazan; Fiscal Year: 1993
    ..The ionized Ca2+ then activates both a phospholipase A2, leading to arachidonic acid release, and lipoxygenase enzymes, resulting in formation of leukotrienes (e.g...
  11. GLYCEROLIPIDS & PROSTAGLANDIN SYNTHESIS IN EYE TISSUES
    ATA ABDEL LATIF; Fiscal Year: 1993
    ..The central hypothesis to be tested is that phospholipase A2 (PLA2) activation is a major source for AA release in the ICB...
  12. ACTION OF LIPOLYTIC ENZYMES
    EDWARD DENNIS; Fiscal Year: 1990
    Studies are proposed (i) on the phospholipase A2 from cobra venom (Naja naja naja) which is among the smallest and most well-studied enzymes of complex lipid metabolism and (ii) on the phospholipases which have been implicated in the ..
  13. GLYCEROLIPIDS AND PROSTAGLANDIN BIOSYNTHESIS
    ATA ABDEL LATIF; Fiscal Year: 2001
    ..The central hypothesis to be tested is that phospholipase A2 (PLA2) activation is a major source for AA release in the ICB...
  14. Lysosomal phospholipase A2 in autoimmune disease
    JAMES ALAN SHAYMAN; Fiscal Year: 2010
    ..Our laboratory discovered, cloned, and characterized a novel phospholipase A2 named lysosomal phospholipase A2. This enzyme is distinct among the family of phospholipase A2s...
  15. DIETARY PUFA EFFECTS ON LCAT REACTIVITY
    John Parks; Fiscal Year: 1999
    ..PC molecules, since we have observed an inverse relationship between PC molecular area on monolayers and LCAT phospholipase A2 activity. To test our hypotheses we will accomplish 2 specific aims...
  16. Regulation of Lipid Mediators in Spinal Microglia and Astrocytes
    Edward A Dennis; Fiscal Year: 2010
    ..Many of these lipids are derived from the reaction catalyzed by phospholipase A2 (PLA2)...
  17. Peroxiredoxin 6 and Cataractogenesis
    Dhirendra P Singh; Fiscal Year: 2010
    ..6 (PRDX6), a 'moonlighting protein'with both GSH peroxidase and aiPLA2 (acidic Ca2+independent phospholipase A2) activities, is highly expressed in lens...
  18. Peroxiredoxin 6 and Cataractogenesis
    DHIRENDRA SINGH; Fiscal Year: 2009
    ..6 (PRDX6), a 'moonlighting protein' with both GSH peroxidase and aiPLA2 (acidic Ca2+independent phospholipase A2) activities, is highly expressed in lens...
  19. Smooth muscle cell lipid metabolism and serum amyloid A
    Barbara M Schreiber; Fiscal Year: 2010
    ..Our gene microarray analysis showed that SAA induces expression of secretory phospholipase A2 (sPLA2) and calcium-dependent cytosolic phospholipase A2 (cPLA2)...
  20. Smooth muscle cell lipid metabolism and serum amyloid A
    Barbara Schreiber; Fiscal Year: 2007
    ..Our gene microarray analysis showed that SAA induces expression of secretory phospholipase A2 (sPLA2) and calcium-dependent cytosolic phospholipase A2 (cPLA2)...
  21. Calcium-Independent PLA2Beta in Beta-Cell Apoptosis
    Sasanka Ramanadham; Fiscal Year: 2010
    ..Our hypothesis in the 1st project period (10/04-7/09) was that the group VIA Ca2+-independent phospholipase A2 (iPLA2) participates in ER stress-induced -cell apoptosis...
  22. Studies of Eicosanoid Biosynthetic Proteins
    Wonhwa Cho; Fiscal Year: 2010
    Arachidonic acid (AA), which is liberated from membrane phospholipids by phospholipase A2 (PLA2), is converted to oxidized lipids collectively known as eicosanoids, including prostaglandins and leukotrienes (LT), through the ..
  23. ANGIOTENSINS, PROSTAGLANDINS-ADRENERGIC INTERACTIONS
    KAFAIT MALIK; Fiscal Year: 2006
    ..NE)- and Ang II stimulate calcium/calmodulin dependent protein kinase II (CaMKII) phosphorylate cytosolic phospholipase A2 (cPLA2) and release AA in vascular smooth muscle cells (VSMC); AA metabolltes formed via cytochrome P450 (..
  24. INTERFACIAL CATALYSIS BY PHOSPHOLIPASE A2
    Mahendra Jain; Fiscal Year: 1993
    Several processes are regulated by interfacial catalysis on the membrane surfaces. Thus phospholipase A2 (PLA2) are interesting not only as prototypes for interfacial catalysis in general, but also because they mobilize precursors for the ..