WHSC1L1

Summary

Gene Symbol: WHSC1L1
Description: Wolf-Hirschhorn syndrome candidate 1-like 1
Alias: NSD3, pp14328, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, WHSC1-like protein 1, histone-lysine N-methyltransferase NSD3, nuclear SET domain-containing protein 3, protein whistle
Species: human

Top Publications

  1. ncbi The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?
    I Stec
    MGC Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    FEBS Lett 473:1-5. 2000
  2. ncbi The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3
    Shaila Rahman
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 31:2641-52. 2011
  3. ncbi Transforming properties of 8p11-12 amplified genes in human breast cancer
    Zeng Quan Yang
    Breast Cancer Program and Systems and Computational Biology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 70:8487-97. 2010
  4. ncbi Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation
    Rui Fang
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 39:222-33. 2010
  5. ncbi The NSD3L histone methyltransferase regulates cell cycle and cell invasion in breast cancer cells
    Zhangle Zhou
    Department of Human Genetics, Aarhus University, Denmark
    Biochem Biophys Res Commun 398:565-70. 2010
  6. ncbi NUP98-NSD3 fusion gene in radiation-associated myelodysplastic syndrome with t(8;11)(p11;p15) and expression pattern of NSD family genes
    Takeshi Taketani
    Division of Blood Transfusion, Shimane University Hospital, Izumo, Shimane, Japan
    Cancer Genet Cytogenet 190:108-12. 2009
  7. ncbi Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer
    Isabelle Bernard-Pierrot
    UMR 144, Centre National de la Recherche Scientifique, Institut Curie, Paris, France
    Cancer Res 68:7165-75. 2008
  8. ncbi NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis
    Gang G Wang
    Department of Pathology, University of California at San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Nat Cell Biol 9:804-12. 2007
  9. ncbi Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity
    Sung Mi Kim
    Department of Life Science, College of Natural Sciences, Chung Ang University, Seoul 156 756, South Korea
    Biochem Biophys Res Commun 345:318-23. 2006
  10. ncbi High-resolution genomic profiles of human lung cancer
    Giovanni Tonon
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:9625-30. 2005

Research Grants

  1. Breast cancer oncogenes on the 8p11 amplicon
    Stephen P Ethier; Fiscal Year: 2010

Scientific Experts

  • Ioannis Panagopoulos
  • I Stec
  • P O Angrand
  • Zeng Quan Yang
  • Stephen P Ethier
  • Stephen Ethier
  • Shaila Rahman
  • Masayo Morishita
  • Yang Shi
  • Rui Fang
  • Zhangle Zhou
  • Takeshi Taketani
  • Isabelle Bernard-Pierrot
  • Gang G Wang
  • Sung Mi Kim
  • Giovanni Tonon
  • Roberto Rosati
  • Matthias Ottinger
  • J Wade Harper
  • Mathew E Sowa
  • Peter M Howley
  • Eric di Luccio
  • Jennifer A Smith
  • Pinchao Mei
  • Yufei Xu
  • Ursula B Kaiser
  • Michael Rutenberg
  • Christine Lian
  • Junmin Peng
  • Thiago Leonor
  • Yujiang Geno Shi
  • Guangchao Sui
  • Anders Lade Nielsen
  • Dongmei Cheng
  • Guo Cheng Yuan
  • Rune Thomsen
  • Fei Lan
  • Andrew J Barbera
  • Søren Kahns
  • Qing Bi
  • Yasuhide Hayashi
  • Hideo Nakamura
  • Junichi Masuda
  • Masafumi Taniwaki
  • Tomohiko Taki
  • Anne Vincent-Salomon
  • Nicolas Stransky
  • Nadège Gruel
  • Celine Vallot
  • Fabien Reyal
  • Virginie Raynal
  • Francois Radvanyi
  • Gaelle Pierron
  • Olivier Delattre
  • Mark P Kamps
  • Ling Cai
  • Martina P Pasillas
  • Gwang Hyeon Eom
  • Young Soo Kim
  • Hyun Kook
  • Ji Young Kim
  • Nak Won Choe
  • Hoon Kook
  • Sang Beom Seo
  • Hae Jin Kee
  • Seong Ki Kim
  • Lynda Chin
  • Deepak B Khatry
  • Mingjian James You
  • Kwok-Kin Wong
  • Gautam Maulik
  • Eric S Martin
  • Yunyu Zhang
  • Ronald A Depinho
  • Andrew J Aguirre
  • Cameron Brennan
  • Alexei Protopopov
  • KWOK KIN WONG
  • Hongbin Ji
  • Bin Feng
  • Cristina Mecucci
  • Teresa Vallespi
  • Ana Aventin
  • Angelo Veronese
  • Roberta La Starza
  • Massimo Negrini
  • Christine Schwienbacher
  • Massimo F Martelli

Detail Information

Publications15

  1. ncbi The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?
    I Stec
    MGC Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    FEBS Lett 473:1-5. 2000
    ..Due to its position, the composition of amino acids close to the PWWP motif and the pattern of other domains present, we hypothesize that the domain is involved in protein-protein interactions...
  2. ncbi The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3
    Shaila Rahman
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 31:2641-52. 2011
    ..We found that the extraterminal (ET) domain, whose function has to date not been determined, interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5...
  3. ncbi Transforming properties of 8p11-12 amplified genes in human breast cancer
    Zeng Quan Yang
    Breast Cancer Program and Systems and Computational Biology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 70:8487-97. 2010
    ..b>WHSC1L1, DDHD2, and ERLIN2 were most potently transforming oncogenes based on the number of altered phenotypes expressed ..
  4. ncbi Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation
    Rui Fang
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 39:222-33. 2010
    ..of the LSD2 complex reveals that LSD2 forms active complexes with euchromatic histone methyltransferases G9a and NSD3 as well as cellular factors involved in transcription elongation...
  5. ncbi The NSD3L histone methyltransferase regulates cell cycle and cell invasion in breast cancer cells
    Zhangle Zhou
    Department of Human Genetics, Aarhus University, Denmark
    Biochem Biophys Res Commun 398:565-70. 2010
    NSD3/WHSC1L1 histone methyltransferase gene aberrations are observed in leukemia and in breast and lung carcinomas, suggesting that NSD3 is implicated in carcinogenesis...
  6. ncbi NUP98-NSD3 fusion gene in radiation-associated myelodysplastic syndrome with t(8;11)(p11;p15) and expression pattern of NSD family genes
    Takeshi Taketani
    Division of Blood Transfusion, Shimane University Hospital, Izumo, Shimane, Japan
    Cancer Genet Cytogenet 190:108-12. 2009
    ..NUP98-NSD3 fusion transcripts have been detected previously in one patient with AML and one patient with t-MDS having t(8;11)(..
  7. ncbi Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer
    Isabelle Bernard-Pierrot
    UMR 144, Centre National de la Recherche Scientifique, Institut Curie, Paris, France
    Cancer Res 68:7165-75. 2008
    ..series of 152 ductal breast carcinomas and 21 cell lines identified five genes (LSM1, BAG4, DDHD2, PPAPDC1B, and WHSC1L1) within the amplified region as consistently overexpressed due to an increased gene copy number...
  8. ncbi NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis
    Gang G Wang
    Department of Pathology, University of California at San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Nat Cell Biol 9:804-12. 2007
    ..protein 1 (NSD1) prototype is a family of mammalian histone methyltransferases (NSD1, NSD2/MMSET/WHSC1, NSD3/WHSC1L1) that are essential in development and are mutated in human acute myeloid leukemia (AML), overgrowth syndromes, ..
  9. ncbi Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity
    Sung Mi Kim
    Department of Life Science, College of Natural Sciences, Chung Ang University, Seoul 156 756, South Korea
    Biochem Biophys Res Commun 345:318-23. 2006
    ..Overexpression of WHISTLE repressed transcription of the SV40 promoter. Our results suggest that WHISTLE is a novel SET domain containing a protein with specific H3K4 and H3K27 HMTase activity...
  10. ncbi High-resolution genomic profiles of human lung cancer
    Giovanni Tonon
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:9625-30. 2005
    ..Integrated DNA-RNA analyses identified WHSC1L1 and TPX2 as two candidates likely targeted for amplification in both pancreatic ductal adenocarcinoma and non-..
  11. ncbi Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13)
    Ioannis Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, Sweden
    Genes Chromosomes Cancer 36:107-12. 2003
    The NUP98 gene at 11p15 is known to be fused to DDX10, HOXA9, HOXA11, HOXA13, HOXD11, HOXD13, LEDGF, NSD1, NSD3, PMX1, RAP1GDS1, and TOP1 in various hematologic malignancies...
  12. ncbi NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15)
    Roberto Rosati
    Hematology and Bone Marrow Transplantation Unit, University of Perugia, Italy
    Blood 99:3857-60. 2002
    Fusion between the NUP98 and NSD3 genes in a patient with acute myeloid leukemia associated with t(8;11)(p11.2;p15), is reported for the first time. The t(8;11)(p11.2;p15) was identified by classical cytogenetics...
  13. ncbi WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3
    I Stec
    MGC Department of Human Genetics and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Genomics 76:5-8. 2001
    ..These genes, WHSC1L1 and WHSC1L2P, map to human chromosomes 8p11.2 and 17q21, respectively...
  14. ncbi NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines
    P O Angrand
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch Cedex, C U de Strasbourg, F 67404, France
    Genomics 74:79-88. 2001
    We describe the isolation and characterization of NSD3, the third member of a gene family including Nsd1 and NSD2...
  15. ncbi Structural insights into the regulation and the recognition of histone marks by the SET domain of NSD1
    Masayo Morishita
    School of Applied Biosciences, Kyungpook National University, Daegu 702 701, South Korea
    Biochem Biophys Res Commun 412:214-9. 2011
    ..nuclear receptor binding SET domain (NSD) protein is a family of three HMTases, NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1 that are critical in maintaining the chromatin integrity...

Research Grants2

  1. Breast cancer oncogenes on the 8p11 amplicon
    Stephen P Ethier; Fiscal Year: 2010
    ..The most potently transforming genes identified, which include DDHD2, SPFH2, LSM1 and WHSC1L1, induce growth factor independent proliferation, anchorage-independent growth, invasive capacity, and altered ..