UBC

Summary

Gene Symbol: UBC
Description: ubiquitin C
Alias: HMG20, polyubiquitin-C
Species: human

Top Publications

  1. ncbi HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation
    Jinwoo Ahn
    Department of Structural Biology, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 285:37333-41. 2010
  2. ncbi Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu
    Andrey A Tokarev
    Department of Medicine University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0679, USA
    J Virol 85:51-63. 2011
  3. ncbi Herpes simplex virus type 1 immediate-early protein ICP0 and is isolated RING finger domain act as ubiquitin E3 ligases in vitro
    Chris Boutell
    Medical Research Council Virology Unit, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 76:841-50. 2002
  4. ncbi Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    Sergio E Alvarez
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, 1101 E Marshall Street, Richmond, Virginia 23298, USA
    Nature 465:1084-8. 2010
  5. ncbi Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15
    Atsushi Okumura
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 103:1440-5. 2006
  6. ncbi De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    Ingrid E Wertz
    Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA
    Nature 430:694-9. 2004
  7. ncbi Analysis of human immunodeficiency virus type 1 Gag ubiquitination
    Eva Gottwein
    Abteilung Virologie, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    J Virol 79:9134-44. 2005
  8. ncbi Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps
    Javier G Magadán
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 6:e1000869. 2010
  9. ncbi Ribosomal protein S7 is both a regulator and a substrate of MDM2
    Yan Zhu
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Mol Cell 35:316-26. 2009
  10. ncbi Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology
    Donald S Kirkpatrick
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Nat Cell Biol 8:700-10. 2006

Research Grants

  1. ATP-Ubiquitin Dependent Proteolysis
    Arthur L Haas; Fiscal Year: 2011
  2. ATP-Ubiquitin Dependent Proteolysis
    Arthur L Haas; Fiscal Year: 2010
  3. FUNCTION OF AN INTERFERON INDUCED UBIQUITIN HOMOLOG
    Arthur Haas; Fiscal Year: 2003
  4. Analysis of ubiquitination enzymes in C. elegans
    Lynn Boyd; Fiscal Year: 2005
  5. ATP-Ubiquitin Dependent Proteolysis
    Arthur L Haas; Fiscal Year: 2010
  6. UBIQUITINATION LENS PROLIFERATION/DIFFERENTIATION
    Allen Taylor; Fiscal Year: 2003
  7. UBIQUITIN DEFICIENCY IN AGING AND NEURODEGENERATION
    Ron Kopito; Fiscal Year: 2006
  8. Adenosine, Toll-Like Receptors and Angiogenesis
    Samuel Joseph Leibovich; Fiscal Year: 2010
  9. Adenosine, Toll-Like Receptors and Angiogenesis
    SAMUEL LEIBOVICH; Fiscal Year: 2009
  10. TRIALS TO ENHANCE ELDERS TOOTH/ORAL HEALTH (TEETH)
    Asuman Kiyak; Fiscal Year: 2001

Detail Information

Publications244 found, 100 shown here

  1. ncbi HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation
    Jinwoo Ahn
    Department of Structural Biology, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 285:37333-41. 2010
    ..Taken together, our results show that the CRL4(DCAF1) E3 ubiquitin ligase can be subverted by Vpr to target UNG2 for degradation...
  2. ncbi Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu
    Andrey A Tokarev
    Department of Medicine University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0679, USA
    J Virol 85:51-63. 2011
    ..Serine-threonine ubiquitination of BST-2 is likely part of the mechanism by which Vpu counteracts innate defenses...
  3. ncbi Herpes simplex virus type 1 immediate-early protein ICP0 and is isolated RING finger domain act as ubiquitin E3 ligases in vitro
    Chris Boutell
    Medical Research Council Virology Unit, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 76:841-50. 2002
    ..We conclude that ICP0 has the potential to act as an E3 ubiquitin ligase during viral infection and to target specific cellular proteins for destruction by the 26S proteasome...
  4. ncbi Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    Sergio E Alvarez
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, 1101 E Marshall Street, Richmond, Virginia 23298, USA
    Nature 465:1084-8. 2010
    ..These results also highlight the key role of SphK1 and its product S1P in TNF-alpha signalling and the canonical NF-kappaB activation pathway important in inflammatory, antiapoptotic and immune processes...
  5. ncbi Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15
    Atsushi Okumura
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 103:1440-5. 2006
    ..Identification of ISG15 as the critical component in IFN-mediated inhibition of HIV-1 release advances the understanding of the IFN-mediated inhibition of HIV-1 replication and uncovers a target for the anti HIV-1 therapy...
  6. ncbi De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    Ingrid E Wertz
    Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA
    Nature 430:694-9. 2004
    ..We also provide an example of a protein containing separate ubiquitin ligase and DUB domains, both of which participate in mediating a distinct regulatory effect...
  7. ncbi Analysis of human immunodeficiency virus type 1 Gag ubiquitination
    Eva Gottwein
    Abteilung Virologie, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    J Virol 79:9134-44. 2005
    ..In summary, these results indicate that HIV-1 Gag can be monoubiquitinated in all domains and that ubiquitination of lysine residues outside p6 may thus contribute to viral release and/or infectivity...
  8. ncbi Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps
    Javier G Magadán
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 6:e1000869. 2010
    ..The multiple levels at which Vpu engages these cellular quality control mechanisms underscore the importance of ensuring profound suppression of CD4 to the life cycle of HIV-1...
  9. ncbi Ribosomal protein S7 is both a regulator and a substrate of MDM2
    Yan Zhu
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Mol Cell 35:316-26. 2009
    ..This indicates that MDM2 ubiquitination of S7 is involved in sustaining the p53 response. Thus, S7 functions as both effector and affector of MDM2 to ensure a proper cellular response to different stress signals...
  10. ncbi Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology
    Donald S Kirkpatrick
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Nat Cell Biol 8:700-10. 2006
    ..Together, our observations expand the context of what can be considered to be a sufficient degradation signal and provide unique insights into the mechanisms of substrate ubiquitination...
  11. ncbi The emerging complexity of protein ubiquitination
    David Komander
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK
    Biochem Soc Trans 37:937-53. 2009
    ..For example, ubiquitination may have important allosteric roles in protein regulation that are currently not appreciated...
  12. ncbi Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells
    Sonya G Fonseca
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    J Clin Invest 120:744-55. 2010
    ..These results reveal a role for WFS1 in the negative regulation of ER stress signaling and in the pathogenesis of diseases involving chronic, unresolvable ER stress, such as pancreatic beta cell death in diabetes...
  13. ncbi TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Signal 3:ra42. 2010
    ..These results indicate that the status of K63-linked ubiquitination of Beclin-1 plays a key role in regulating autophagy during inflammatory responses...
  14. ncbi The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress
    Olga Mikhaylova
    Department of Molecular Oncogenesis, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237 0505, USA
    Mol Cell Biol 28:2701-17. 2008
    ..These data indicate that through this novel pathway involving P1465 hydroxylation and Ser5 phosphorylation of Rbp1, pVHL may regulate tumor growth...
  15. ncbi SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor
    K G Suresh Kumar
    Department of Animal Biology, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6046, USA
    EMBO J 22:5480-90. 2003
    ..These findings characterize SCF(HOS) as an E3 ubiquitin ligase that is essential for ubiquitination, proteolysis and down-regulation of IFNAR1, and implicate HOS in the regulation of cellular responses to IFNalpha...
  16. ncbi COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase
    Gabriel N Maine
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    EMBO J 26:436-47. 2007
    ..Our data uncover that ubiquitination and degradation of NF-kappaB subunits by this COMMD1-containing ubiquitin ligase is a novel and critical mechanism of regulation of NF-kappaB-mediated transcription...
  17. ncbi Monoubiquitylation promotes mitochondrial p53 translocation
    Natasha D Marchenko
    Department of Pathology, Stony Brook University, Stony Brook, New York, NY 11794 869, USA
    EMBO J 26:923-34. 2007
    ....
  18. ncbi Mechanism of hypoxia-induced GCM1 degradation: implications for the pathogenesis of preeclampsia
    Meng Hsiu Chiang
    Graduate Institute of Biochemical Sciences, National Taiwan University, and Division of High Risk Pregnancy, Mackay Memorial Hospital, Taipei, Taiwan
    J Biol Chem 284:17411-9. 2009
    ..Our study identifies a molecular basis for the disrupted GCM1 transcription network in preeclampsia and provides a potential avenue for therapeutic intervention...
  19. ncbi Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)
    Akiyoshi Komuro
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Oncogene 23:6914-23. 2004
    ..Importantly, WWP1 and Smurfs were expressed in distinct patterns in human tissues and carcinoma cell lines, suggesting unique pathophysiological roles of WWP1 and Smurfs...
  20. ncbi Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking
    Elaine M Khan
    Signal Transduction Laboratory, Department of Internal Medicine, University of California, School of Medicine, Davis, California, 95616, USA
    FASEB J 22:910-7. 2008
    ..Therefore, exposure to CS, like exposure to H2O2, results in prolonged signaling by the EGFR and may contribute to uncontrolled lung cell growth...
  21. ncbi von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination
    Anna V Kuznetsova
    Department of Molecular and Cellular Physiology, Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0576, USA
    Proc Natl Acad Sci U S A 100:2706-11. 2003
    ..This interaction is regulated by UV radiation...
  22. ncbi Ubiquitylated Tax targets and binds the IKK signalosome at the centrosome
    Y Kfoury
    Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
    Oncogene 27:1665-76. 2008
    ..These observations highlight an unsuspected link between Tax-induced IKK activation and the centrosome...
  23. ncbi NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein
    Chloé Journo
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 3015, Institut Pasteur, Paris, France
    PLoS Pathog 5:e1000521. 2009
    ..Our data strongly suggest for the first time that NRP is a critical adaptor that regulates the assembly of TAX1BP1 and post-translationally modified forms of Tax1, leading to sustained NF-kappaB activation...
  24. ncbi Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
    Kaisa Haglund
    Ludwig Institute for Cancer Research, Husargatan 3, SE 75 124 Uppsala, Sweden
    Nat Cell Biol 5:461-6. 2003
    ..Thus, monoubiquitination is the principal signal responsible for the movement of RTKs from the plasma membrane to the lysosome...
  25. ncbi FBW2 targets GCMa to the ubiquitin-proteasome degradation system
    Chih Sheng Yang
    Graduate Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan
    J Biol Chem 280:10083-90. 2005
    ..Our study identifies the SCF(hFBW2) E3 complex as the key machinery that targets hGCMa to the ubiquitin-proteasome degradation system...
  26. ncbi Targeted knockdown of SEPT9_v1 inhibits tumor growth and angiogenesis of human prostate cancer cells concomitant with disruption of hypoxia-inducible factor-1 pathway
    Sharon Amir
    Prostate Cancer Research Laboratory, Department of Urology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mol Cancer Res 8:643-52. 2010
    ..These results provide new insights and validation for applying SEPT9_v1 as a potential target for antitumor therapy by interrupting the HIF-1 pathway...
  27. ncbi HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK
    Qiong Lin
    Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822, USA
    Mol Cell Biol 30:1541-54. 2010
    ..Our findings suggest an essential role of Nedd4-1 in regulation of EGFR degradation through interaction with and ubiquitination of ACK...
  28. ncbi Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion
    Mariola J Edelmann
    Department of Clinical Medicine, University of Oxford, Oxford, UK
    FEBS J 277:2515-30. 2010
    ..This effect is modulated by post-translational modifications of OTUB1, suggesting a new entry point for manipulating Yersinia interactions with the host...
  29. ncbi cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
    Mathieu J M Bertrand
    Montreal Neurological Institute, McGill University, Montreal, Quebec H3A2B4, Canada
    Mol Cell 30:689-700. 2008
    ..When deubiquitinated by AEG40730 treatment, RIP1 binds caspase-8 and induces apoptosis. These findings provide insights into the function of the IAPs and provide new therapeutic opportunities in the treatment of cancer...
  30. ncbi Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kappaB
    Tiejun Zhao
    Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Kyoto, Japan
    Blood 113:2755-64. 2009
    ..Selective suppression of the classical NF-kappaB pathway by HBZ renders the alternative NF-kappaB pathway predominant after activation of NF-kappaB by Tax or other stimuli, which might be critical for oncogenesis...
  31. ncbi Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation
    Luke Gaughan
    Prostate Research Group, Northern Institute for Cancer Research Paul, O Gorman Building University of Newcastle Upon Tyne, Medical School Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Nucleic Acids Res 33:13-26. 2005
    ..In all, our data indicates a novel role for Mdm2 in regulating components of the AR transcriptosome...
  32. ncbi Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis
    Suguru Koyama
    Department of Enzymatic Regulation for Cell Functions Calpain Project, Tokyo Metropolitan Institute of Medical Science Rinshoken, Tokyo 113 8613, Japan
    J Mol Biol 376:1224-36. 2008
    ....
  33. ncbi Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
    Chee Kwee Ea
    Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell 22:245-57. 2006
    ..These results reveal the biochemical mechanism underlying the essential signaling function of NEMO and provide direct evidence that signal-induced site-specific ubiquitination of RIP1 is required for IKK activation...
  34. ncbi Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress
    Tony T Huang
    Department of Pharmacology, University of Wisconsin Madison, 301 SMI, 1300 University Avenue, Madison, WI 53706, USA
    Cell 115:565-76. 2003
    ..These SUMO and ubiquitin modification pathways may serve as anticancer drug targets...
  35. ncbi Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity
    Paul C Evans
    Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Biochem J 378:727-34. 2004
    ..A20 did not have a global effect on ubiquitinated cellular proteins, which indicates that its activity is target-specific. The biological significance of the catalytic domain is unknown...
  36. ncbi Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane
    Tianhui Hu
    Cancer Research Center, Xiamen University Medical College, Xiamen, 361005 Fujian, China
    J Biol Chem 285:13561-8. 2010
    ..These results provide a mechanism by which NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation...
  37. ncbi Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-kappaB activation
    Rihab Nasr
    Department of Internal Medicine, American University of Beirut, PO Box 113 6044, Beirut, Lebanon
    Blood 107:4021-9. 2006
    ..Thus, ubiquitylation and sumoylation of the same residues of Tax regulate 2 essential steps controlling NF-kappaB activation, demonstrating how these posttranslational modifications can cooperate to promote Tax-induced transformation...
  38. ncbi Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction
    Zhonghua Lu
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 177:1077-89. 2007
    ..These results identify a synapse-associated E3 ubiquitin ligase as an important regulator of MuSK signaling...
  39. ncbi Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation
    Kah Leong Lim
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:2002-9. 2005
    ..Our results suggest that parkin is a dual-function ubiquitin ligase and that K63-linked ubiquitination of synphilin-1 by parkin may be involved in the formation of Lewy body inclusions associated with PD...
  40. ncbi Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
    Thijn R Brummelkamp
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nature 424:797-801. 2003
    ..We show that this effect can be relieved by aspirin derivatives that inhibit NF-kappaB activity, which suggests a therapeutic intervention strategy to restore growth control in patients suffering from familial cylindromatosis...
  41. ncbi Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin
    Radu Vasilcanu
    Department of Oncology Pathology, Cellular and Molecular Tumor Pathology, Cancer Center Karolinska, CCK R8 04, Karolinska Institutet, S 17176, Stockholm, Sweden
    Mol Pharmacol 73:930-9. 2008
    ..Thus, apart from inhibiting the receptor activity, PPP can induce IGF-1R ubiquitination and stimulate ERK in an Mdm2-dependent manner. This response could contribute to the apoptotic effect of PPP...
  42. ncbi Phosphorylation of activation function-1 regulates proteasome-dependent nuclear mobility and E6-associated protein ubiquitin ligase recruitment to the estrogen receptor beta
    Nathalie Picard
    Research Center, Ste Justine Hospital, 3175 Cote Ste Catherine, Montreal, Quebec, Canada
    Mol Endocrinol 22:317-30. 2008
    ....
  43. ncbi Redox-mediated modification of PLZF by SUMO-1 and ubiquitin
    Soo Im Kang
    Laboratory of Cellular and Molecular Biochemistry, School of Life Sciences and Biotechnology, Korea University, 1 5 Anam dong, Sungbuk Ku, Seoul, 136 701, South Korea
    Biochem Biophys Res Commun 369:1209-14. 2008
    ..On the basis of these results, we propose that PLZF post-translational modification is controlled by intracellular ROS, and the biological function of PLZF is regulated by sumoylation and ubiquitination...
  44. ncbi MEK1-dependent delayed expression of Fos-related antigen-1 counteracts c-Fos and p65 NF-kappaB-mediated interleukin-8 transcription in response to cytokines or growth factors
    Elke Hoffmann
    Institute of Pharmacology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Biol Chem 280:9706-18. 2005
    ..Relative to c-Fos, the delayed recruitment of Fra-1 to the IL-8 promoter provides an example how AP-1 subunits may dampen excessive chemokine synthesis...
  45. ncbi T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain
    Ana Lucia Giannini
    Department of Immunobiology, King s College London, 2nd Floor New Guy s House, Guy s Hospital, St Thomas Street, London SE1 9RT, UK
    Biochem J 410:101-11. 2008
    ..The identification of these novel modifications, interactions, domains and relatives significantly widens the contexts for investigating TRAC-1 activity and regulation...
  46. ncbi MDM2 is a novel E3 ligase for HIV-1 Vif
    Taisuke Izumi
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Sakyo ku, Japan
    Retrovirology 6:1. 2009
    ..These data suggest that MDM2 is a regulator of HIV-1 replication and might be a novel therapeutic target for anti-HIV-1 drug...
  47. ncbi Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway
    Hiroko Yaguchi
    Tumor Endocrinology Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Mol Cell Biol 24:6569-80. 2004
    ..These findings reveal that MEN1-causing missense mutations lead to a loss of function of menin due to enhanced proteolytic degradation, which may be a common mechanism for inactivating tumor suppressor gene products in familial cancer...
  48. ncbi LQT1-associated mutations increase KCNQ1 proteasomal degradation independently of Derlin-1
    David Peroz
    INSERM, UMR915, Nantes, France
    J Biol Chem 284:5250-6. 2009
    ..Small interfering RNA knock-down of Derlin-1 did not modify KCNQ1 expression level, and no interaction between endogenous KCNQ1 and Derlin-1 could be detected...
  49. ncbi Derlin-1 and p97/valosin-containing protein mediate the endoplasmic reticulum-associated degradation of human V2 vasopressin receptors
    Isabel Schwieger
    Leibniz Institut fur Molekulare Pharmakologie FMP, Campus Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Mol Pharmacol 73:697-708. 2008
    ..Our results demonstrate the presence of a Derlin-1-mediated ERAD pathway degrading wild-type and disease-causing V2R mutants with different misfolded domains in a mammalian system...
  50. ncbi LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals
    Hayley J Thirkettle
    Uro Oncology Research Group, Cancer Research UK
    Clin Cancer Res 15:3003-13. 2009
    ..LYRIC/AEG-1 contains three uncharacterized nuclear localization signals (NLS), which may regulate its distribution and, ultimately, function in cells...
  51. ncbi Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation
    Daniel F Legler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH 1066 Epalinges, Switzerland
    Immunity 18:655-64. 2003
    ..We suggest that lipid rafts are crucial for the outcome of TNFalpha-activated signaling pathways...
  52. ncbi ERK1/2 achieves sustained activation by stimulating MAPK phosphatase-1 degradation via the ubiquitin-proteasome pathway
    Yun Wei Lin
    Molecular Carcinogenesis Laboratory, Institute of Biotechnology, Department of Life Sciences, National Tsing Hua University, Hsinchu 300, Taiwan, Republic of China
    J Biol Chem 278:21534-41. 2003
    ..Taken together, these results demonstrate that activated ERK1/2 can trigger MKP-1 degradation via the ubiquitin-proteasome pathway, thus facilitating long-term activation of ERK1/2 against cytotoxicity...
  53. ncbi Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death
    Yatender Kumar
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research CSIR, Uppal Road, Hyderabad 500007, India
    Biochem J 427:91-104. 2010
    ..Our results suggest a role for ubiquitination of Ipaf that is enabled by its interaction with Sug1, leading to caspase 8 activation and cell death...
  54. ncbi TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains
    Silvia Zucchelli
    Sector of Neurobiology, International School for Advanced Studies SISSA, Area Science Park, S S 14, Km 163 5, Basovizza, 34012 Trieste, Italy
    Hum Mol Genet 19:3759-70. 2010
    ..In human post-mortem brains of PD patients, TRAF6 protein colocalizes with aSYN in LBs. These results reveal a novel role for TRAF6 and for atypical ubiquitination in PD pathogenesis...
  55. ncbi Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E
    Takayuki Murata
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Japan
    J Biol Chem 281:20788-800. 2006
    ....
  56. ncbi Molecular interaction between HAX-1 and XIAP inhibits apoptosis
    Young Ji Kang
    Medical Proteomics Research Center, KRIBB, Daejeon 305 806, Republic of Korea
    Biochem Biophys Res Commun 393:794-9. 2010
    ....
  57. ncbi Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases
    Marion P Butler
    Institute of Immunology, National University of Ireland Maynooth, County Kildare, Ireland
    J Biol Chem 282:29729-37. 2007
    ....
  58. ncbi Modulation of HIV-1 Rev protein abundance and activity by polyubiquitination with unconventional Lys-33 branching
    Anne Laure Vitte
    Laboratoire de Biologie Moleculaire de la Cellule, UMR5161 CNRS ENS de Lyon, IFR 128 Biosciences Lyon Gerland, 46 allee d Italie, 69364 Lyon Cedex 07, France
    FEBS Lett 580:6155-60. 2006
    ..These observations support the notion that polyubiquitination of Rev stabilizes the viral protein but hinders its activity...
  59. ncbi Ubiquitin-dependent proteolysis of trihydrophobin 1 (TH1) by the human papilloma virus E6-associated protein (E6-AP)
    Yanzhong Yang
    Key Laboratory of Medical Molecular Virology Ministry of Education and Health, Gene Research Center, Shanghai Medical College and Institutes of Biomedical Science of Fudan University, Shanghai 200032, P R China
    J Cell Biochem 101:167-80. 2007
    ..The degradation is blocked by treatment with proteasome inhibitor MG132. Herein, we provide strong evidence that TH1 is a specific substrate that is targeted for degradation through E6-AP-catalyzed polyubiquitination...
  60. ncbi Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination
    Meng K Lim
    Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Tokyo, Japan
    Exp Cell Res 313:2858-74. 2007
    ..These findings demonstrate a cell-type dependent functional interaction between parkin and LIMK1 and provide new evidence that links parkin and LIMK1 in the pathogenesis of familial PD...
  61. ncbi HDAC2 promotes cell migration/invasion abilities through HIF-1? stabilization in human oral squamous cell carcinoma
    Cheng Chi Chang
    Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan
    J Oral Pathol Med 40:567-75. 2011
    ..It suggests a possible link between the migration/invasion potential of oral cancer cells and the prevalent expression of HDAC2...
  62. ncbi 1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination
    Ryuki Kohta
    Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Neurochem 114:1291-301. 2010
    ..Taken together, substances which reduce polyubiquitination of tubulin such as 1BnTIQ are supposed to be candidates of etiological factors of PD...
  63. ncbi CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
    Eirini Trompouki
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, 34 Alexander Fleming Street, Vari 16672, Greece
    Nature 424:793-6. 2003
    ..These results indicate that CYLD is a negative regulator of the cytokine-mediated activation of NF-kappaB that is required for appropriate cellular homeostasis of skin appendages...
  64. ncbi Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons
    Jason Howitt
    Florey Neuroscience Institutes and Centre for Neuroscience, The University of Melbourne, Parkville, Victoria 3010, Australia
    Proc Natl Acad Sci U S A 106:15489-94. 2009
    ..Together, this evidence suggests a critical role for Ndfip1 in regulating metal transport in human neurons...
  65. ncbi p34SEI-1 inhibits doxorubicin-induced senescence through a pathway mediated by protein kinase C-delta and c-Jun-NH2-kinase 1 activation in human breast cancer MCF7 cells
    Sae Lo Oom Lee
    Research Center for Women s Diseases, Division of Biological Sciences, Sookmyung Women s University, Seoul, Korea
    Mol Cancer Res 7:1845-53. 2009
    ..Therefore, p34(SEI-1) inhibits senescence by inducing PKC-delta ubiquitination and preventing PKC-delta-dependent phosphorylation of JNK1...
  66. ncbi Caenorhabditis elegans UBC-1, a ubiquitin-conjugating enzyme homologous to yeast RAD6/UBC2, contains a novel carboxy-terminal extension that is conserved in nematodes
    D S Leggett
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada
    DNA Cell Biol 14:883-91. 1995
    ..Here we report the isolation and characterization of the Caenorhabditis elegans RAD6 homolog designated ubc-1. Ubc-1 encodes a 21...
  67. ncbi Genome analysis and functional characterization of the E2 and RING-type E3 ligase ubiquitination enzymes of Arabidopsis
    Edward Kraft
    Section of Molecular and Cellular Biology, Division of Biological Sciences, University of California, Davis, California 95616, USA
    Plant Physiol 139:1597-611. 2005
    Attachment of ubiquitin to substrate proteins is catalyzed by the three enzymes E1, E2 (ubiquitin conjugating [UBC]), and E3 (ubiquitin ligase)...
  68. ncbi Overexpression of three ubiquitin genes in mouse epidermal tumors is associated with enhanced cellular proliferation and stress
    J S Finch
    Department of Radiation Oncology, University of Arizona Medical School, Tucson 85724
    Cell Growth Differ 3:269-78. 1992
    ..4, 2.8, 6.4, and 7.8 kilobases (kb) were detected by an oligonucleotide specific for a mouse UbC polyubiquitin clone. A 1...
  69. ncbi Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins
    Donald Jones
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 1Z3, Canada
    Genome Biol 3:RESEARCH0002. 2002
    ..We describe the results of RNA interference (RNAi) experiments on the E1s, UBC/E2s and ubiquitin-like proteins in Caenorhabditis elegans. We also present a phylogenetic analysis of UBCs.
  70. ncbi Interactions within the ubiquitin pathway of Caenorhabditis elegans
    Michelle Gudgen
    Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Biochem Biophys Res Commun 325:479-86. 2004
    ..A total of 31 E2-E3 interactions were uncovered. In addition, the UBC-13 conjugating enzyme was observed to interact with two different E2s, UEV-1 and UBC-1...
  71. ncbi A site-directed approach for constructing temperature-sensitive ubiquitin-conjugating enzymes reveals a cell cycle function and growth function for RAD6
    K S Ellison
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    J Biol Chem 266:24116-20. 1991
    ..the gene sequence of a temperature-sensitive allele of the cell cycle-related ubiquitin-conjugating enzyme CDC34 (UBC 3) from Saccharomyces cerevisiae...
  72. ncbi The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins
    Sjoerd J L van Wijk
    Department of Physiological Chemistry, Division of Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    FASEB J 24:981-93. 2010
    ..of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain...
  73. ncbi Target gene approaches: Gene expression in Daphnia magna exposed to predator-borne kairomones or to microcystin-producing and microcystin-free Microcystis aeruginosa
    Anke Schwarzenberger
    University of Cologne, Zoological Institute, Aquatic Chemical Ecology, 50923 Cologne, Germany
    BMC Genomics 10:527. 2009
    ..This information is obtained by constructing phylogenetic trees of candidate genes with the knowledge that the Daphnia genome is composed of many expanded gene families...
  74. ncbi Ubiquitin and ubiquitin-conjugated protein expression in the rat cerebral cortex and hippocampus following traumatic brain injury (TBI)
    Xianglan Yao
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814 4799, USA
    Brain Res 1182:116-22. 2007
    ..Quantitative real-time polymerase chain reaction results indicated that mRNA levels of ubA52, ubB and ubC in the ipsilateral cerebral cortex were significantly decreased on Day 1 post-TBI, that ubC mRNA levels also were ..
  75. ncbi Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer
    A P VanDemark
    Department of Biophysics and Biophysical Chemistry, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Cell 105:711-20. 2001
    ..UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in ..
  76. ncbi Polyubiquitin is a new phenotypic marker of contractile vascular smooth muscle cells
    P J Adam
    Department of Medicine, Addenbrookes Hospital, University of Cambridge, UK
    Cardiovasc Res 33:416-21. 1997
    ..The aim of this study was to identify and characterise a 2.8 kb transcript, 2E10, which was highly expressed in freshly dispersed rat aortic VSMCs and downregulated in multiply passaged cultured VSMCs...
  77. ncbi AtCHIP functions as an E3 ubiquitin ligase of protein phosphatase 2A subunits and alters plant response to abscisic acid treatment
    Jinhua Luo
    Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA
    Plant J 46:649-57. 2006
    ..Like its animal orthologs, AtCHIP interacts with a unique class of ubiquitin-conjugating enzymes (UBC or E2) that belongs to the stress-inducible UBC4/5 class in yeast...
  78. ncbi Prolonged amelioration of acute lung allograft rejection by overexpression of human interleukin-10 under control of a long acting ubiquitin C promoter in rats
    Uz Stammberger
    Division of General Thoracic Surgery, University Hospital, Bern, Switzerland
    J Heart Lung Transplant 25:1474-9. 2006
    The prolonged effect of electroporation-mediated human interleukin-10 (hIL-10) overexpression in skeletal muscle under the control of the constitutional polyubiquitin C promoter (pUb hIL-10) on rat lung allograft rejection was evaluated.
  79. ncbi Evolution of the mouse polyubiquitin-C gene
    Andrey A Perelygin
    Department of Biology, Georgia State University, 24 Peachtree Center Avenue, Atlanta, GA 30303, USA
    J Mol Evol 55:202-10. 2002
    ..Here we report the sequences of the polyubiquitin-C (Ubc) genes in two mouse strains...
  80. ncbi Control of rapsyn stability by the CUL-3-containing E3 ligase complex
    Seunghee Nam
    Research Center for Cellulomics, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, 151 742 Seoul, Korea
    J Biol Chem 284:8195-206. 2009
    ..Through RNA interference screening, we found that UBC-1, UBC-12, NEDD-8, and RBX-1 were required for degradation of RPY-1...
  81. ncbi DNA damage after phototherapy in wounded fibroblast cells irradiated with 16 J/cm(2)
    Alwin B Mbene
    Laser Research Group, Faculty of Health Sciences, University of Johannesburg, P O Box 17011, Doornfontein, Johannesburg 2028, South Africa
    J Photochem Photobiol B 94:131-7. 2009
    ..It has been shown to induce DNA damage; however this damage appears to be repairable. This study aimed to determine the effects of phototherapy induced DNA damage and activation of the DNA repair gene methylpurine DNA glycosylase (MPG)...
  82. ncbi Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
    L Deng
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Cell 103:351-61. 2000
    ..fingerprinting analysis reveals that this complex is composed of the ubiquitin conjugating enzyme Ubc13 and the Ubc-like protein Uev1A...
  83. ncbi The mouse polyubiquitin gene Ubb is essential for meiotic progression
    Kwon Yul Ryu
    Department of Biological Sciences, Bio X Program, Stanford University, Stanford, California 94305, USA
    Mol Cell Biol 28:1136-46. 2008
    Ubiquitin is encoded in mice by two polyubiquitin genes, Ubb and Ubc, that are considered to be stress inducible and two constitutively expressed monoubiquitin (Uba) genes...
  84. ncbi An advanced communication skills course for fourth-year, post-clerkship students
    Angela Towle
    University of British Columbia, Vancouver, Canada
    Acad Med 77:1165-6. 2002
    ..Relationships" was planned and implemented in 2000-01 at the University of British Columbia (UBC)...
  85. ncbi The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease
    John S Bett
    King s College London School of Medicine, Department of Medical and Molecular Genetics, King s College London, London, United Kingdom
    J Cell Mol Med 13:2645-57. 2009
    ..We crossed R6/2 transgenic HD mice with heterozygous polyubiquitin Ubc knockout mice (Ubc+/-) and assessed the effect on the R6/2 neurological phenotype...
  86. ncbi The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance
    Kwon Yul Ryu
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    EMBO J 26:2693-706. 2007
    b>UbC is one of two stress-inducible polyubiquitin genes in mammals and is thought to supplement the constitutive UbA genes in maintaining cellular ubiquitin (Ub) levels during episodes of cellular stress...
  87. ncbi Quantification of oxidative stress in live mouse embryonic fibroblasts by monitoring the responses of polyubiquitin genes
    Han Wook Ryu
    Department of Life Science, University of Seoul, Seoul 130 743, Republic of Korea
    Biochem Biophys Res Commun 404:470-5. 2011
    ..in mouse embryonic fibroblasts, in which one allele of the ubiquitin-coding region of the polyubiquitin gene Ubb or Ubc was replaced by the eGFP-puro cassette, thereby placing GFP expression under the control of the endogenous ..
  88. ncbi Arabidopsis thaliana UBC13: implication of error-free DNA damage tolerance and Lys63-linked polyubiquitylation in plants
    Rui Wen
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada
    Plant Mol Biol 61:241-53. 2006
    ..To date, Ubc13 is the only known ubiquitin-conjugating enzyme (Ubc) capable of catalyzing the Lys63-linked polyubiquitylation reaction and this function requires interaction with the ..
  89. ncbi Tsg101, an inactive homologue of ubiquitin ligase e2, interacts specifically with human immunodeficiency virus type 2 gag polyprotein and results in increased levels of ubiquitinated gag
    Erin L Myers
    Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Virol 76:11226-35. 2002
    ..The interaction requires the L domain PTAPP motif in the p6 domain of HIV-2 Gag and the N-terminal Ubc-conjugation homology domain of Tsg101. Tsg101 is incorporated into HIV-2 virions...
  90. ncbi Establishment of a partially informative porcine somatic cell hybrid panel and assignment of the loci for transition protein 2 (TNP2) and protamine 1 (PRM1) to chromosome 3 and polyubiquitin (UBC) to chromosome 14
    G Rettenberger
    Abteilung Klinische Genetik, Universitat Ulm, Germany
    Genomics 21:558-66. 1994
    ..Using this panel, we assigned the locus encoding polyubiquitin (UBC) to chromosome 14, and the transition protein 2 locus (TNP2) and protamine loci (PRM1 and PRM2) to chromosome 3...
  91. ncbi The E2-25K ubiquitin-associated (UBA) domain aids in polyubiquitin chain synthesis and linkage specificity
    Randall C Wilson
    Laboratory for Structural Biology, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Biochem Biophys Res Commun 405:662-6. 2011
    ..contain a C-terminal ubiquitin-associated (UBA) domain as well as the conserved catalytic ubiquitin-conjugating (UBC) domain...
  92. ncbi Expression of polyubiquitin and heat-shock protein 70 genes increases in the later stages of disease progression in scrapie-infected mouse brain
    N Kenward
    Department of Biochemistry, University of Nottingham Medical School, Queen s Medical Centre, England
    J Neurochem 62:1870-7. 1994
    We have shown by northern analyses that the expression of the mouse polyubiquitin C gene is increased severalfold in the brains of mice infected with both the ME7 and 87V strains of scrapie...
  93. ncbi Comparative diagnostic value of urine cytology, UBC-ELISA, and fluorescence in situ hybridization for detection of transitional cell carcinoma of urinary bladder in routine clinical practice
    Matthias May
    Department of Urology, Institute of Pathology, Rostock University, Rostock, Germany
    Urology 70:449-53. 2007
    ..We comparatively tested cytology, FISH, and the cytokeratin-detection test of urinary bladder cancer (UBC) in routine clinical practice.
  94. ncbi Comparison of the 5' upstream region of the evolutionarily equivalent polyubiquitin gene of humans and Chinese hamsters
    M Nenoi
    Training School, National Institute of Radiological Sciences, Inage Ku, Chiba shi, Japan
    Gene 179:297-9. 1996
    ..polyubiquitin gene CHUB2 was determined, and compared to that of the evolutionarily equivalent polyubiquitin gene UbC of humans...
  95. ncbi Nucleotide sequence and expression of the rat polyubiquitin mRNA
    T Hayashi
    Department of Biochemistry, Jikei University School of Medicine, Tokyo, Japan
    Biochim Biophys Acta 1218:232-4. 1994
    ..These clones were rat homologues for human UbB and UbC gene families, respectively. 1.2 kb UbB transcript, as well as 2.8 kb and 3...
  96. ncbi Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules
    Byoung Hee Lee
    Institute for Animal Experimentation, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Virus Res 98:83-91. 2003
    ..proteins PIAS1, PIASxbeta, HIPK2, CHD3, and TTRAP, which interacted with the SUMO-1 conjugating enzyme (Ubc-9) and SUMO-1 in the yeast two-hybrid assay...
  97. ncbi Validation of putative reference genes for gene expression studies in human hepatocellular carcinoma using real-time quantitative RT-PCR
    Vito R Cicinnati
    Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    BMC Cancer 8:350. 2008
    ..Here, a systematic evaluation of six putative reference genes for gene expression studies in human hepatocellular carcinoma (HCC) is presented...
  98. ncbi [Pathologic proximal femoral fractures in children in an unicameral bone cyst]
    P Havranek
    Klinika detské chirurgie a traumatologie 3 LF UK, Fakultní Thomayerova nemocnice, Praha
    Acta Chir Orthop Traumatol Cech 72:282-6. 2005
    ..material, find out the incidence of this pathologic fracture, the extent and shape of the unicameral bone cyst (UBC), specific therapeutic approach, technical problems of eventual osteosynthesis, number of reoperations and sequels.
  99. ncbi Synthesis and characterization of 2,3-dibromopropyl-2,4,6-tribromophenyl ether (DPTE) and structurally related compounds evidenced in seal blubber and brain
    Roland von der Recke
    Institute of Food Chemistry, University of Hohenheim, Garbenstrasse 28, D 70599 Stuttgart, Germany
    Environ Sci Technol 41:1590-5. 2007
    The unknown compound UBC-1 previously described as the major organobromine contamination in the blubber extract of a hooded seal (Cystophora cristata) from the Barents Sea was identified as 2,3-dibromopropyl-2,4,6-tribromophenyl ether (..
  100. ncbi Unbound bilirubin associated with kernicterus: a historical approach
    C E Ahlfors
    Department of Pediatrics, Division of Neonatology, California Pacific Medical Center, San Francisco, California 94118, USA
    J Pediatr 137:540-4. 2000
    To determine the unbound bilirubin concentration (UBC) associated with kernicterus with the use of clinical data from clusters of kernicterus after sulfisoxazole and benzyl alcohol administration.
  101. ncbi Diagnostic performance of the urinary bladder carcinoma antigen ELISA test and multiparametric DNA/cytokeratin flow cytometry in urine voided samples from patients with bladder carcinoma
    M Sanchez-Carbayo
    Servicio de Bioquimica, Hospital Universitario de Salamanca, Centro de Investigacion del Cancer Instituto mixto de Biologia Molecular y Celular del Cancer, Salamanca, Spain
    Cancer 92:2811-9. 2001
    ..and specificity of flow cytometric DNA/cytokeratin 8/18 measurements and the urinary bladder carcinoma antigen (UBC) enzyme linked immunoabsorbent assay (ELISA) test for the detection of bladder carcinoma in voided urine samples.

Research Grants77

  1. ATP-Ubiquitin Dependent Proteolysis
    Arthur L Haas; Fiscal Year: 2011
    ..proteins and will examine the role of the carboxyl terminal 2-grasp domain as a specificity filter for cognate E2/Ubc recognition, the role of 2-grasp domain versus Ubc12 amino-terminal peptide binding in transition state ..
  2. ATP-Ubiquitin Dependent Proteolysis
    Arthur L Haas; Fiscal Year: 2010
    ..proteins and will examine the role of the carboxyl terminal 2-grasp domain as a specificity filter for cognate E2/Ubc recognition, the role of 2-grasp domain versus Ubc12 amino-terminal peptide binding in transition state ..
  3. FUNCTION OF AN INTERFERON INDUCED UBIQUITIN HOMOLOG
    Arthur Haas; Fiscal Year: 2003
    ..bear remarkable yet cryptic sequence similarity to the conserved catalytic domain of ubiquitin conjugating enzymes (Ubc). The present proposal comprises three specific aims...
  4. Analysis of ubiquitination enzymes in C. elegans
    Lynn Boyd; Fiscal Year: 2005
    ..via a three-step pathway utilizing the E1 ubiquitin activating enzyme (E1), the E2 ubiquitin conjugating enzymes (Ubc), and the E3 ubiquitin ligases (E3)...
  5. ATP-Ubiquitin Dependent Proteolysis
    Arthur L Haas; Fiscal Year: 2010
    ..1 ubiquitin-like proteins andwillexaminetheroleofthecarboxylterminal -graspdomainasaspecificityfilterforcognateE2/Ubc recognition, the role of -grasp domain versus Ubc12 amino-terminal peptide binding in transition state ..
  6. UBIQUITINATION LENS PROLIFERATION/DIFFERENTIATION
    Allen Taylor; Fiscal Year: 2003
    ..infection of lens cells with adenovirus, and 2) the contributions of dominant negative constructs of all available Ubc and Ubc knockout mice from Drs. Pagano and Wing...
  7. UBIQUITIN DEFICIENCY IN AGING AND NEURODEGENERATION
    Ron Kopito; Fiscal Year: 2006
    ..Mice harboring deletions of the two polyubiquitin genes, UbB and UbC will be bred and intercrossed to produce lines containing progressively severe ubiquitin deficiencies...
  8. Adenosine, Toll-Like Receptors and Angiogenesis
    Samuel Joseph Leibovich; Fiscal Year: 2010
    ..A2ARs deleted in both endothelial and hematopoietic cells, reconstitution with bone marrow from wild type mice (UbC-GFP mice) will be performed. 4. The role of the macrophage HIF11-I.1 isoform in wound healing: HIF11-I...
  9. Adenosine, Toll-Like Receptors and Angiogenesis
    SAMUEL LEIBOVICH; Fiscal Year: 2009
    ..A2ARs deleted in both endothelial and hematopoietic cells, reconstitution with bone marrow from wild type mice (UbC-GFP mice) will be performed. 4. The role of the macrophage HIF11-I.1 isoform in wound healing: HIF11-I...
  10. TRIALS TO ENHANCE ELDERS TOOTH/ORAL HEALTH (TEETH)
    Asuman Kiyak; Fiscal Year: 2001
    ..effort between the University of Washington (UW), the coordinating center, and the University of British Columbia (UBC)...
  11. Regulatory Mechanisms of Implant-Induced Osteolysis
    Yousef Abu Amer; Fiscal Year: 2010
    ..that a variety of upstream signals augment ubiquitination-based signaling network dominated by TAK1/TABs/RIP/NEMO/UBC complex. Thus, we propose to investigate the following specific aims: 1...
  12. Cerebellar Microcircuits: Organization & Development
    Enrico Mugnaini; Fiscal Year: 2010
    ..The UBC has typically only one dendrite that terminates with a brush of dendrioles;these establish a giant excitatory ..
  13. Cerebellar Microcircuits: Organization & Development
    Enrico Mugnaini; Fiscal Year: 2009
    ..The UBC has typically only one dendrite that terminates with a brush of dendrioles; these establish a giant excitatory ..
  14. Cb1-b in T Cell Activation and Tolerance
    Yun Cai Liu; Fiscal Year: 2006
    ..that the RING finger of Cbl, a Cbl-b homologue, can recruit and activate ubiquitin (Ub) conjugation enzyme (Ubc), and that Cbl then facilitates Ub conjugation to the protein tyrosine kinases it associates with, may suggest that ..
  15. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006
    ..to: (1) investigate molecular and structural aspects of uterine wound healing in MRL/MpJ+/+; C57BL/6 ; C57BL/6-Tg(UBC-GFP)30Scha and B6...
  16. Cerebellar Microcircuits: Organization and Development
    Enrico Mugnaini; Fiscal Year: 2007
    ..proposes a series of studies intended to further clarify the typology of the cerebellar unipolar brush cell (UBC), a type of granular layer interneuron that has been promoted by the applicant's laboratory over the last several ..
  17. CEREBELLAR MICROCIRCUITS--ORGANIZATION AND DEVELOPMENT
    Enrico Mugnaini; Fiscal Year: 2003
    The unipolar brush cell (UBC) is a newly discovered interneuron situated in the granular layer of the mammalian cerebellum...
  18. Developmental function of Rb family proteins
    David S Fay; Fiscal Year: 2010
    ..We have also uncovered a complementary pathway that acts to control organ morphogenesis through UBC-18/UbcH7, a conserved ubiquitin-conjugating enzyme involved in the targeting of proteins for degradation...
  19. Developmental function of Rb family proteins
    DAVID FAY; Fiscal Year: 2009
    ..We have also uncovered a complementary pathway that acts to control organ morphogenesis through UBC-18/UbcH7, a conserved ubiquitin-conjugating enzyme involved in the targeting of proteins for degradation...
  20. RISK GENES IN ALZHEIMERS DISEASE
    M Kamboh; Fiscal Year: 2000
    ..of the putative functional mutation, 5) to evaluate the role of known polymorphisms in the c-FOS CTSG, CTSD, UBC, IL1A, IL1B and IL1RN genes and their joint effects with the APOE and ACT polymorphisms in affecting the risk of AD,..
  21. DEGRADATION OF E12/E47 IN SMOOTH MUSCLE CELLS
    Gordon Huggins; Fiscal Year: 2002
    ..They are expressed in VSMC. The applicant cloned a novel ubiquitin conjugating enzyme, UBC-E2A, directed against the E12 and E47...
  22. CBL IN T CELL ACTIVATION
    Yun Cai Liu; Fiscal Year: 2006
    ..through the interaction of Cbl protein binding domains and through the RING finger-dependent recruitment of Ubc E2s; Second, Cbl negatively regulates intracellular signal transduction in thymocytes and peripheral T cells via ..