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Genomes and Genes
| TRIB1SummaryGene Symbol: TRIB1 Description: tribbles homolog 1 (Drosophila) Alias: C8FW, GIG2, SKIP1, TRB1, G-protein-coupled receptor induced protein, G-protein-coupled receptor-induced gene 2 protein, G-protein-coupled receptor-induced protein 2, GIG-2, TRB-1, phosphoprotein regulated by mitogenic pathways, tribbles homolog 1, tribbles-like protein 1 Species: human Top Publications
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Publications
Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cellsF Wilkin
Institut de Recherche Interdisciplinaire, Universite Libre de Bruxelles, Brussels, Belgium
Eur J Biochem 248:660-8. 1997..Immunofluorescence and subcellular fractionation analysis have revealed that c-myc-tagged clone c5fw was insoluble and localized mainly in the cytoplasm, in the form of granules...- Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIPChao Xu
Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230026, China
J Biol Chem 281:15900-8. 2006..The biological implication of this binding with spliceosome rearrangement during activation is discussed... - Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathwaysHye Youn Sung
Cardiovascular Research Unit and Section of Infection, Inflammation and Immunity, University of Sheffield, and Department of Histopathology, Northern General Hospital, Sheffield S10 2TN, United Kingdom
J Biol Chem 282:18379-87. 2007..In summary, the data presented here suggest an important regulatory role for trb-1 in vascular smooth muscle cell biology... - Human tribbles, a protein family controlling mitogen-activated protein kinase cascadesEndre Kiss-Toth
Cardiovascular Research Unit, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, United Kingdom
J Biol Chem 279:42703-8. 2004..These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK... - Polygenic determinants of severe hypertriglyceridemiaJian Wang
Vascular Biology Research Group 2 Clinical Trials Group, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
Hum Mol Genet 17:2894-9. 2008..We determined genotypes for: GALNT2 rs4846914, TBL2/MLXIPL rs17145738, TRIB1 rs17321515, ANGPTL3 rs12130333, GCKR rs780094, APOA5 rs3135506 (S19W), APOA5 rs662799 (-1131T > C), APOE (isoforms).. - SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcriptionMin Wu
Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
J Biol Chem 278:27072-9. 2003..Taken together, these data suggest that SINK is critically involved in a novel negative feedback control pathway of NF-kappaB-induced gene expression... - Polymorphism at the TRIB1 gene modulates plasma lipid levels: insight from the Spanish familial hypercholesterolemia cohort studyA García-Rios
Reina Sofia University Hospital, Instituto Maimonides de Investigacion Biomedica de Cordoba IMIBIC, 14004 Cordoba, University of Cordoba, CIBER Fisiopatologia de la Obesidad y Nutricion, Spain
Nutr Metab Cardiovasc Dis 21:957-63. 2011..Therefore, our aims were to assess the association of the rs17321515 (TRIB1) SNP with plasma lipids concentrations and anthropometric variables and to explore the interaction between this .. - Human Tribbles homolog 1 functions as a negative regulator of retinoic acid receptorMasamichi Imajo
Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
Genes Cells 15:1089-97. 2010..In this study, we uncover a novel function of human Tribbles homolog 1 (Trib1) as a regulator of retinoic acid receptor (RAR) signaling... - Trib1 links the MEK1/ERK pathway in myeloid leukemogenesisTakashi Yokoyama
Division of Carcinogenesis, The Cancer Institute, Tokyo, Japan
Blood 116:2768-75. 2010b>Trib1 is a myeloid oncogene that cooperates with Hoxa9 and Meis1... - Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart StudyMary E Keebler
Massachusetts General Hospital, Boston, MA 02115, USA
Circ Cardiovasc Genet 3:358-64. 2010..Genome-wide association studies in cohorts of European descent have identified novel genomic regions as associated with lipids, but their relevance in African Americans remains unclear... - Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemiaPriya H Dedhia
Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Blood 116:1321-8. 2010b>Trib1, Trib2, and Trib3 are mammalian homologs of Tribbles, an evolutionarily conserved Drosophila protein family that mediates protein degradation... - Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samplesDaphna Weissglas-Volkov
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7088, USA
Circ Cardiovasc Genet 3:31-8. 2010.... - Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemiaDaniel C Gilby
Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom
Immunol Lett 130:115-24. 2010..This may lead to enhanced cell survival, and therefore contribute to pathogenesis of the disease. Trb-1/trb-2 may, therefore, represent useful therapeutic targets for the treatment of AML in patients with dys-regulated trb activity... - A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemiaRobert A Hegele
Vascular Biology Research Group, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
Hum Mol Genet 18:4189-94. 2009..We found that several SNPs associated with TG in normolipidemic samples, including APOA5 p.S19W and -1131T>C, TRIB1 rs17321515, TBL2 rs17145738, GCKR rs780094, GALNT2 rs4846914 and ANGPTL3 rs12130333, were significantly associated .. - Expression regulation and functional characterization of a novel interferon inducible gene Gig2 and its promoterJun Jiang
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 7 Donghu South Road, Wuhan 430072, China
Mol Immunol 46:3131-40. 2009Grass carp hemorrhagic virus (GCHV)-induced gene 2 (Gig2) is a novel gene previously identified from UV-inactivated GCHV-treated Carassius auratus blastulae embryonic (CAB) cells, suggesting that it should play a pivotal role in the .. - Characterization of mammary epithelial cell line HC11 using the NIA 15k gene array reveals potential regulators of the undifferentiated and differentiated phenotypesC Perotti
Department of Biological Sciences, University of Calgary, 2500 University Drive, N W Calgary, AB, Canada T2N 1N4
Differentiation 78:269-82. 2009..cells (Lgals1, Ran, Jam-A and Bmpr1a) and in those induced to undergo differentiation (Id1, Nfkbiz, Trib1, Rps21, Ier3)... - TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general populationAnette Varbo
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev, Denmark
Arterioscler Thromb Vasc Biol 31:451-7. 2011The goal of this study was to test whether TRIB1-rs2954029 and GCKR-rs1260326 associate with lipid levels and risk of ischemic heart disease (IHD) and myocardial infarction (MI) in the general population. - Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in miceRalph Burkhardt
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York, USA
J Clin Invest 120:4410-4. 2010..This locus contains only one annotated gene, tribbles homolog 1 (TRIB1), which has not previously been implicated in lipoprotein metabolism... - Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasmaJohn C Chambers
Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
Nat Genet 43:1131-8. 2011..glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and .. - Genomic survey of early responses to viruses in Atlantic salmon, Salmo salar LAleksei Krasnov
Nofima, 1432 As, Norway
Mol Immunol 49:163-74. 2011..exclusively in fish species there were members of several multigene families: tripartite motif proteins, gig1- and gig2-like proteins... - Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease riskSebastiano Calandra
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
J Lipid Res 52:1885-926. 2011..systems (NPC1L1, ABCG5/8); the incorporation of dietary sterols (MTP) and of de novo synthesized lipids (HMGCR, TRIB1) into apoB-containing lipoproteins (APOB) and their release into the circulation (ANGPTL3, SARA2, SORT1); and .. - Implications of discoveries from genome-wide association studies in current cardiovascular practicePanniyammakal Jeemon
Panniyammakal Jeemon, Kerry Pettigrew, Christopher Sainsbury, Sandosh Padmanabhan, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, United Kingdom
World J Cardiol 3:230-47. 2011..CELSR2, PSRC1 and SORT1 genes have been associated with CHD, and TMEM57, DOCK7, CELSR2, APOB, ABCG5, HMGCR, TRIB1, FADS2/S3, LDLR, NCAN and TOMM40-APOE with total cholesterol... - EphB6 receptor modulates micro RNA profile of breast carcinoma cellsLokesh Bhushan
Department of Basic Medical Sciences, Western University of Health Sciences, Pomona, California, United States of America
PLoS ONE 6:e22484. 2011..selection approach that allowed the identification of SMARCA5, SMARCC1, eIF2C2, eIF2C4, eIF4EBP2, FKABP5, FKBP1A, TRIB1, TRIB2, TRIB3, BMPR2, BMPR1A and BMPR1B as important targets of a subset of significantly altered miRNAs... - Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic strokeLuca Jaromi
Department of Medical Genetics, University of Pecs, Szigeti ut 12, 7624, Pecs, Hungary
Neuromolecular Med 13:179-86. 2011..rs12130333 located within the ANGPTL3 locus; rs16996148 residing at the CILP2 gene locus; and rs17321515 at the TRIB1 locus, which were originally reported in association with decreased triglyceride levels; therefore, we .. - Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanksStephen D Turner
Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
PLoS ONE 6:e19586. 2011..modifying medications to construct a more rigorous HDL-C phenotype, we identified an association between HDL-C and TRIB1, a gene which previously resisted identification in studies with larger sample sizes... - Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cellsChunyu Zhang
Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, 37 Convent Dr, Rm 1118B, Bethesda, MD 20892, USA
Mol Cancer Ther 10:1137-48. 2011..those induced by PIAs only (DUSP1, KLF6, CENTD2, BHLHB2, and PREX1), those commonly induced by PIAs and LY (TRIB1, KLF2, RHOB, and CDKN1A), and those commonly suppressed by PIAs and LY (IGFBP3, PCNA, PRIM1, MCM3, and HSPA1B)... - Association of germline or somatic TP53 missense mutation with oncogene amplification in tumors developed in patients with Li-Fraumeni or Li-Fraumeni-like syndromeWaka Sugawara
Department of Cancer Diagnosis, Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan
Genes Chromosomes Cancer 50:535-45. 2011..1 containing DEPDC6 and the other at 8q24.2 containing TRIB1, MYC, and PVT1... - A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortiumAldi T Kraja
Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, Missouri, USA
Diabetes 60:1329-39. 2011..Variants in the genes LPL, CETP, APOA5 (and its cluster), GCKR (and its cluster), LIPC, TRIB1, LOC100128354/MTNR1B, ABCB11, and LOC100129150 were further tested for their association with individual .. - Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformationTakashi Yokoyama
Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
Cancer Sci 102:1115-22. 2011..b>Trib1 and Trib2 have been identified as myeloid oncogenes, and both may be involved in human leukemia... - Large scale replication analysis of loci associated with lipid concentrations in a Japanese populationK Nakayama
Division of Human Genetics, Center for Community Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke City, Tochigi, 329 0498 Japan
J Med Genet 46:370-4. 2009..To date, large scale replication studies using populations with known differences in genome-wide linkage disequilibrium (LD) pattern have not been undertaken... - Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart StudyRahul C Deo
Department of Genetics, Harvard Medical School, Boston, MA, USA
PLoS Genet 5:e1000342. 2009.... - Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cellsLioudmila V Sharova
Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, NIH, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA
DNA Res 16:45-58. 2009..Median estimated half-life was 7.1 h and only <100 genes, including Prdm1, Myc, Gadd45 g, Foxa2, Hes5 and Trib1, showed half-life less than 1 h... - Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiencyMasahiro Yamamoto
Department of Host Defense and Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
J Exp Med 204:2233-9. 2007..b>Trib1 is reportedly involved in the regulation of NF-kappaB and MAP kinases, as well as gene expression in vitro... - TRIB1 overexpression in acute myeloid leukemiaBenno Röthlisberger
Center of Laboratory Medicine, Kantonsspital Aarau, CH 5000 Arau, Switzerland
Cancer Genet Cytogenet 176:58-60. 2007..Real-time reverse-transcription polymerase chain reaction analysis revealed that MYC and TRIB1 (a gene also localized on 8q24, close to MYC) were clearly overexpressed when compared with healthy donors, acute .. - Comparative transcript profiles of cell cycle-related genes in mouse primordial germ cells, embryonic stem cells and embryonic germ cellsEleonora Sorrentino
Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome, Italy
Gene Expr Patterns 7:714-21. 2007..Among 38 genes of the G1 phase analysed, Ccnd3 (CyclinD3), Cdkn1c (p57(kip2)), Rb1, and Tceb1l (Skip1-like) were expressed at significantly higher levels in PGCs than in EG and ES cells; Ccnd1 (CyclinD1) was more .. - Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesisGuang Jin
Department of Carcinogenesis, The Cancer Institute, Genome Center, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
Blood 109:3998-4005. 2007..The mice that received Hoxa9/Meis1-transduced bone marrow cells developed acute myeloid leukemia (AML), and Trib1, Evi1, Ahi1, Raralpha, Pitpnb, and AK039950 were identified as candidate cooperative genes located near common .. - Regulation of Hh/Gli signaling by dual ubiquitin pathwaysJin Jiang
Center for Developmental Biology and Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
Cell Cycle 5:2457-63. 2006..Ci processing is mediated by an SCF (Skip1/Cul1/F-box protein) ubiquitin ligase in which the F-box protein Slimb/beta-TRCP bridges Ci to the ubiquitin ligase... - The innate immune response to grass carp hemorrhagic virus (GCHV) in cultured Carassius auratus blastulae (CAB) cellsYi Bing Zhang
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Wuhan 430072, PR China
Dev Comp Immunol 31:232-43. 2007..Mx1, Mx2, PKR-like, Viperin, IFI56, and other IFN stimulated genes (ISGs) IFI58, ISG15-1, ISG15-2, USP18, Gig1 and Gig2. The identified fish IFN system genes were highly induced by active GCHV, UV-inactivated GCHV, CAB IFN or poly(I)... - Tribbles: novel regulators of cell function; evolutionary aspectsZ Hegedus
Bioinformatics Group, Biological Research Centre, Szeged, Hungary
Cell Mol Life Sci 63:1632-41. 2006..This review summarises our current understanding of tribbles function and also provides an evolutionary perspective on the various tribbles genes... - Negative implication of C-MYC as an amplification target in esophageal cancerXiao Ping Huang
State Key Laboratory of Oncology in Southern China, Department of Thoracic Surgery, Cancer Center, Sun Yat Sen University, Guangzhou, 510060, China
Cancer Genet Cytogenet 165:20-4. 2006..Furthermore, we detected the expression status of several genes including C-MYC, TRIB1 (alias C8FW), and FAM84B (alias NSE2) in the regions of 8q24 via reverse transcriptase-polymerase chain reaction .. - ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathwayWen Liang Kuo
Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60615, USA
J Biol Chem 279:23073-81. 2004..Finally, ERK7 is stabilized by an N-terminal mutant of Cullin-1 suggesting that ERK7 is ubiquitinated by the Skip1-Cullin-F box complex... - SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxiaAlex J Bowers
Department of Cancer Biology, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
Oncogene 22:2823-35. 2003..SKIP3 is an ortholog of the Drosophila tribbles, rat NIPK, dog C5FW, and human C8FW genes... - Identification of gene markers for formaldehyde exposure in humansGuang Yong Li
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea
Environ Health Perspect 115:1460-6. 2007..Inhalation of FA induces sensory irritation at relatively low concentrations. However, little is known concerning the cellular alterations observed after FA exposure in humans... - Characterization of ovarian cancer ascites on cell invasion, proliferation, spheroid formation, and gene expression in an in vitro model of epithelial ovarian cancerMarie Line Puiffe
Centre de Recherche du Centre Hospitalier de l Université de Montréal Institut du cancer de Montréal, Montreal, Quebec, Canada
Neoplasia 9:820-9. 2007..cells exposed to 54 independent ascites demonstrated that stimulatory ascites affected the expression of ISGF3G, TRIB1, MKP1, RGS4, PLEC1, and MOSPD1 genes... - Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay populationE Shyong Tai
Department of Endocrinology, Singapore General Hospital, Singapore
J Lipid Res 50:514-20. 2009..A polymorphism adjacent to the TRIB1 locus (rs17321515) was associated with elevated total cholesterol and LDL-cholesterol (LDL-C) after adjustment for .. - Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotypeKrzysztof Mrozek
Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210 1228, USA
Semin Oncol 35:365-77. 2008..CTNNA1, NF1, ETV6, and TCF4, and amplifications, for example, ERG, ETS2, APP, ETS1, FLI1, MLL, DDX6, GAB2, MYC, TRIB1, and CDX2. Treatment outcomes of complex karyotype patients receiving chemotherapy are very poor... - Double-minute MYC amplification and deletion of MTAP, CDKN2A, CDKN2B, and ELAVL2 in an acute myeloid leukemia characterized by oligonucleotide-array comparative genomic hybridizationAnitha Kamath
Molecular Cytogenetics Laboratory, Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Cancer Genet Cytogenet 183:117-20. 2008..3 containing the MTAP, CDKN2A, CDKN2B, and ELAVL2 genes, and a 3.981-Mb 8q24 double minute containing the TRIB1, FAM84B, MYC, and PVT1 genes, with an average of 30 double minutes in each cell... - Gene expression profiling distinguishes JAK2V617F-negative from JAK2V617F-positive patients in essential thrombocythemiaE Puigdecanet
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia Hospital del Mar, IMAS, Barcelona, Spain
Leukemia 22:1368-76. 2008..a set of 14 genes (CISH, C13orf18, CCL3, PIM1, MAFF, SOCS3, ID2, GADD45B, KLF5, TNF, LAMB3, HRH4, TAGAP and TRIB1) showed an abnormal expression pattern... - Introgression and molecular tagging of Rf (4), a new male fertility restoration gene from wild sunflower Helianthus maximiliani LJiuhuan Feng
Department of Plant Sciences, North Dakota State University, Fargo, ND 58105, USA
Theor Appl Genet 117:241-9. 2008..We identified a new type of CMS, named as CMS GIG2, from an interspecific cross between Helianthus giganteus accession1934 and H. annuus cv. HA 89... - Tribbles-1 as a novel biomarker of chronic antibody-mediated rejectionJoanna Ashton-Chess
INSERM U643, Centre Hospitalier Universitaire Nantes, Institut de Transplantation et de Recherche en Transplantation, Nantes, France
J Am Soc Nephrol 19:1116-27. 2008..Tribbles-1 (TRIB1), a human homolog of Drosophila tribbles, was identified to be a potentially informative biomarker... - Genes encoded within 8q24 on the amplicon of a large extrachromosomal element are selectively repressed during the terminal differentiation of HL-60 cellsTetsuo Hirano
Life Science Group, Graduate School of Integrated Arts and Sciences, Hiroshima University, 1 7 1 Kagamiyama, Higashihiroshima, Hiroshima 739 8521, Japan
Mutat Res 640:97-106. 2008..NSMCE2 (for a SUMO ligase), CCDC26 (for a retinoic acid-dependent modulator of myeloid differentiation), TRIB1 (for a regulator of MAPK kinase) and LOC389637 (for a protein of unknown function), were encoded by the amplicon... - Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humansSekar Kathiresan
Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nat Genet 40:189-97. 2008..PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3)... - Newly identified loci that influence lipid concentrations and risk of coronary artery diseaseCristen J Willer
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
Nat Genet 40:161-9. 2008..cholesterol; near SORT1, with variants primarily associated with low-density lipoprotein (LDL) cholesterol; near TRIB1, MLXIPL and ANGPTL3, with variants primarily associated with triglycerides; and a locus encompassing several genes .. - Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemiaKaren Keeshan
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
Blood Cells Mol Dis 40:119-21. 2008Trib2 is a member of the Trib family of serine/threonine kinase-like proteins (Trib1, Trib2, Trib3)... - Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screeningK Tang
Department of Radiation Oncology and Pathology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, and Karmanos Cancer Institute, Detroit, Michigan 48202, USA
Biochemistry 39:3185-91. 2000..We identified type II keratin 5, lamin A, the cytoplasmic domain of integrin beta4 subunit and a phosphoprotein C8FW as 12-LOX interacting proteins...
Research Grants
- ROLE OF EICOSANOIDS IN TUMOR CELL METASTASISKENNETH HONN; Fiscal Year: 2007..We also identified a novel protein network, comprised of beta4 integrin, lamin A, cytokeratin 5, and phosphoprotein C8FW, which interacts with 12-LOX. When paired with alpha6, beta4 integrin subunit forms a major receptor for laminin...
- Molecular Mechanisms of Leukemogenesis by PMLRAR alphaScott C Kogan; Fiscal Year: 2010..For Aim 3, we will delineate mechanisms through which MYC and TRIB1 (encoded on human chromosome 8) can contribute to APL and assess the potential for targeting MYC therapeutically ..
- Complex regulation of Ci/Gli proteins in Hedgehog signal transductionJin Jiang; Fiscal Year: 2007....
- REGULATION OF HEDGEHOG SIGNALING IN DROSOPHILAJin Jiang; Fiscal Year: 2009..abstract_text> ..
- Complex regulation of Ci/Gli proteins in Hedgehog signal transductionJin Jiang; Fiscal Year: 2009....
- Complex regulation of Ci/Gli proteins in Hedgehog signal transductionJin Jiang; Fiscal Year: 2010....
- Mechanism of Hedgehog Signal transduction across the plasma membraneJin Jiang; Fiscal Year: 2010..Hence, understanding the Hh signaling mechanisms, as proposed by this project, may provide new avenues for improving diagnosis and therapeutics of cancer. ..
- Osteoprotegerin Pathway: Relations of Genes & Biomarkers to CVD in the CommunitySekar Kathiresan; Fiscal Year: 2007..In addition, the candidate will be well positioned to transition from conducting pathway-based investigation to genome-wide association studies for cardiovascular phenotypes. ..
- REGULATION OF HEDGEHOG SIGNALING IN DROSOPHILAJin Jiang; Fiscal Year: 2007..As unconstrained elevation of Smo activity contributes to many human cancers including skin, lung, pancreas, and prostate cancers, our study may provide new avenues for improving diagnosis and therapeutics of these cancers. ..
- Regulation of Hh/Ci signaling by Cos2 and its partnersJin Jiang; Fiscal Year: 2003..abstract_text> ..
- REGULATION OF HEDGEHOG SIGNALING IN DROSOPHILAJin Jiang; Fiscal Year: 2004..Knowledge gained from the proposed study may provide new avenues for diagnosis and therapeutic intervention of cancers caused by mis-regulation of Hh signaling activity. ..
- Role of PI3 Kinase p110alpha in OsteoclastsJin Jiang; Fiscal Year: 2004..These studies could lead to the development of new, specific, bone active pharmaceuticals with the potential to improve dental health. ..
- Regulation of Hh/Ci signaling by Cos2 and its partnersJin Jiang; Fiscal Year: 2006..abstract_text> ..
- Complex regulation of Ci/Gli proteins in Hedgehog signal transductionJin Jiang; Fiscal Year: 2010....