Research Topics
Genomes and Genes
| TIMP4SummaryGene Symbol: TIMP4 Description: TIMP metallopeptidase inhibitor 4 Alias: TIMP-4, metalloproteinase inhibitor 4, tissue inhibitor of metalloproteinase 4, tissue inhibitor of metalloproteinases 4 Species: human Top Publications
Research Grants
| Scientific Experts
|
Detail Information
Publications
Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4J Greene
Human Genome Sciences, Inc, Rockville, Maryland 20850 3338, USA aecom yu edu
J Biol Chem 271:30375-80. 1996..This unique expression pattern suggests that TIMP-4 may function in a tissue-specific fashion in extracellular matrix homeostasis...- Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human plateletsAnna Radomski
Department of Pharmacology, University of Alberta, 9 50 Medical Sciences Building, Edmonton, Ontario, Canada T6G 2H7
Br J Pharmacol 137:1330-8. 2002..11. Human rTIMP-4 exerted a biphasic effect on HT-1080 cells-induced aggregation. 12. Thus, TIMP-4 is the major intraplatelet MMP inhibitor and it is involved in regulation of platelet aggregation and recruitment... - E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A)Linda Troeberg
Kennedy Institute of Rheumatology Division, Imperial College of Science, Technology and Medicine, 1 Aspenlea Road, Hammersmith, London, W6 8LH UK
Biochemistry 41:15025-35. 2002..Similar models of interaction may apply to TIMP-4. The latter low-affinity site functions in conjunction with the active site of MMP-2 to generate a tight enzyme-inhibitor complex... - Tissue inhibitor of metalloproteinases 4 (TIMP4) is involved in inflammatory processes of human cardiovascular pathologyIlpo Koskivirta
Department of Medical Biochemistry and Molecular Biology, University of Turku, Turku, Finland
Histochem Cell Biol 126:335-42. 2006Tissue inhibitors of matrix metalloproteinases (TIMPs) comprise a family of four members, of which TIMP4 is characterized by being primarily restricted to cardiovascular structures... - Oxidised, glycated LDL selectively influences tissue inhibitor of metalloproteinase-3 gene expression and protein production in human retinal capillary pericytesJ L Barth
Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC, USA
Diabetologia 50:2200-8. 2007.... - Catabolic properties of microdissected human endosteal bone lining cellsC Dierkes
Department of Pathology, Justus Liebig University, Langhansstr 10, Giessen 35385, Germany
Calcif Tissue Int 84:146-55. 2009..MMP13 and -14 as well as TIMP1 and -2 were strongly present in lining cells, while MMP2, TIMP3, and TIMP4 showed weak or negative signals... - Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantationTilo Dehne
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, Berlin, 10117, Germany
Arthritis Res Ther 11:R133. 2009.... - Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cellsMonika Szeliga
Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
Glia 57:1014-23. 2009..with real-time PCR analysis for eight genes potentially relevant to malignancy: S100A16, CAPN2, FNDC3B, DYNC1LI1, TIMP4, MGMT, ADM, and TIMP1... - Variation in senescent-dependent lung changes in inbred mouse strainsKewu Huang
Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, Maryland 21205, USA
J Appl Physiol 102:1632-9. 2007..matrix metalloproteinase 9 (Mmp9) in D2 and an increase in tissue inhibitor of matrix metalloproteinase (Timp1 and Timp4) in B6 mice... - Differential gene expression profiling of laryngeal squamous cell carcinoma by laser capture microdissection and complementary DNA microarraysLi Juan Ma
Department of Otolaryngology Head Neck Surgery, Hunan Provincial People s Hospital, Changsha, PR China
Arch Med Res 40:114-23. 2009..The aim of this study was to identify genetic changes associated with the disease pathogenesis and pinpoint genes whose expression is impacted by these genetic alterations... - Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overloadIlpo Koskivirta
Department of Medical Biochemistry and Genetics, University of Turku, FI 20520 Turku, Finland
J Biol Chem 285:24487-93. 2010b>Tissue inhibitor of metalloproteinases 4 (TIMP4) is expressed highly in heart and found dysregulated in human cardiovascular diseases... - Development of a monoclonal antibody that specifically detects tissue inhibitor of metalloproteinase-4 (TIMP-4) in formalin-fixed, paraffin-embedded human tissuesP Scott Donover
Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
J Cell Biochem 110:1255-61. 2010..This study documents TIMP-4 monoclonal antibody clone 9:4-7 as an effective tool for preclinical and clinical investigations... - TIMP-4 and CD63: new prognostic biomarkers in human astrocytomasSandrine Rorive
Department of Pathology, Erasme University Hospital, Brussels, Belgium
Mod Pathol 23:1418-28. 2010..It identifies TIMP-4 and CD63 as markers of the astrocytic phenotype in patients with gliomas. In addition, this work highlights the contribution of high TIMP-4/CD63 co-expression to the adverse outcomes of patients with glioblastomas... - Differential expression of extracellular matrix and adhesion molecule genes in the brain of juvenile versus adult mice in responses to intracerebroventricular administration of IL-1San Ching
Department of Oral Biology, Ohio State University, Columbus, Ohio, USA
Neuroimmunomodulation 14:46-56. 2007..This study compares the differential gene expression patterns of extracellular matrix and adhesion molecules in the brain of juvenile and adult mice... - Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinasesJehoon Lee
Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, United States
Mol Cell Endocrinol 332:306-13. 2011..and/or activity of MMP1, MMP2, MMP3, MMP7 and MMP9 proteins and increases expression of TIMP1, TIMP2, TIMP3, and TIMP4 proteins and thereby decreases migration and invasion of human immortalized endometriotic epithelial and stromal .. - Genomics of cardiac remodeling in angiotensin II-treated wild-type and LOX-1-deficient miceBum Yong Kang
Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Physiol Genomics 42:42-54. 2010..ANG II infusion enhanced expression of genes known to be associated with cardiac remodeling, such as Agt, Ace, Timp4, Fstl, and Tnfrst12a, as well as oxidant stress-related genes Gnaq, Sos1, and Rac1... - Association of adipocyte genes with ASP expression: a microarray analysis of subcutaneous and omental adipose tissue in morbidly obese subjectsRobin E Maclaren
Centre de Recherche Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Quebec, Canada
BMC Med Genomics 3:3. 2010..Subcutaneous (SC) and omental (OM) adipose tissues (n = 21) were analysed by microarray, and biologic pathways in lipid metabolism and inflammation were specifically examined... - Peroxynitrite inactivates human-tissue inhibitor of metalloproteinase-4Sandra Donnini
Departments of Molecular Biology, University of Siena, Via A Moro, 2, Siena 53100, Italy
FEBS Lett 582:1135-40. 2008..HPLC/ESI-MS/MS analysis of peroxynitrite-treated TIMP-4 showed modifications at Y114, Y195, Y188 and Y190. In conclusion, TIMP-4 nitration might be a potential mechanism contributing to cardiovascular disease and cancer... - Promoter polymorphism (rs3755724, -55C/T) of tissue inhibitor of metalloproteinase 4 (TIMP4) as a risk factor for Kawasaki disease with coronary artery lesions in a Korean populationJu Yeon Ban
Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Hoegi dong, Dongdaemun Gu, Seoul, Republic of Korea
Pediatr Cardiol 30:331-5. 2009..Tissue inhibitors of matrix metalloproteinases (TIMPs) comprise a family of four members, of which TIMP4 is characterized by its restriction to cardiovascular structures... - Circulating tissue inhibitor of matrix metalloproteinase-4 (TIMP-4) in systemic sclerosis patients with elevated pulmonary arterial pressureGialafos J Elias
Cardiology Department, Laikon General Hospital, University of Athens Medical School, Athens, Greece
Mediators Inflamm 2008:164134. 2008..03), independently of age, extent of skin sclerosis, or lung fibrosis, suggesting a cardiopulmonary vasculature-specific role of TIMP-4 activation in SSc... - High resolution mapping of Cia3: a common arthritis quantitative trait loci in different speciesXinhua Yu
Section of Immunogenetics, University of Rostock, Germany
J Immunol 182:3016-23. 2009..Five of those 29 genes are differentially expressed or carry nonsynonymous polymorphisms between parental strains: Timp4, Tmem40, Mbd4, Cacna1c, and Lrtm2. Taken together, we refined Cia3 into a 5... - Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot studyAdrien Daigeler
Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789, Bochum, Germany
Langenbecks Arch Surg 395:261-75. 2010..This study focused on these tumors and analyzed the association of gene expression profiles to clinical outcome... - Expression of extracellular matrix genes during myocardial recovery from heart failure after left ventricular assist device supportLeanne E Felkin
Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield, Middlesex, UK
J Heart Lung Transplant 28:117-22. 2009.... - Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotypeCaroline Cheng
Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
Atherosclerosis 204:26-33. 2009..However, ATII also decreased procollagen 5alpha3 expression in downstream lesions and decreased TIMP4 expression in upstream lesions... - Polymorphisms of MMP-3 and TIMP-4 genes affect angiographic coronary plaque progression in non-diabetic and type 2 diabetic patientsQiu Jing Chen
Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China
Clin Chim Acta 405:97-103. 2009..This study examined whether genetic variants of matrix metallopeptidases (MMPs) and their tissue inhibitors (TIMPs) were associated with angiographic coronary plaque progression (PP) in type 2 diabetic and non-diabetic patients... - Donor cell-type specific paracrine effects of cell transplantation for post-infarction heart failureYasunori Shintani
Translational Cardiovascular Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, UK
J Mol Cell Cardiol 47:288-95. 2009..mediators of paracrine effects studied, Fgf2 and Hgf were upregulated only after BMC injection, while Mmp2 and Timp4 were modulated after SMB injection... - TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1Marina Cardellini
Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
Diabetes 58:2396-401. 2009..We tested its association with atherosclerosis in subjects with type 2 diabetes and identified Sirtuin 1 (SirT1) as a major regulator of TIMP3 expression... - Heterogeneity and degree of TIMP4, GATA4, SOX18, and EGFL7 gene promoter methylation in non-small cell lung cancer and surrounding tissuesTatyana Azhikina
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
Cancer Genet 204:492-500. 2011..high resolution melting analysis to assess methylation of CpG islands within the promoters of the TIMP4, GATA4, SOX18, and EGFL7 genes in samples of non-small cell lung cancer and surrounding apparently normal tissue .. - Diabetic impairment of C-kit bone marrow stem cells involves the disorders of inflammatory factors, cell adhesion and extracellular matrix moleculesTao Sheng Li
Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
PLoS ONE 6:e25543. 2011..alterations of the extracellular matrix and adhesion molecules were varied; Pecam, Mmp10, Lamc1, Itgb7, Mmp9, and Timp4 were up-regulated, but Col11a1, Fn1, Admts2, and Itgav were down-regulated... - Effects of continuous-flow versus pulsatile-flow left ventricular assist devices on myocardial unloading and remodelingTomoko S Kato
Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
Circ Heart Fail 4:546-53. 2011..We analyzed the effects of ventricular decompression by continuous-flow versus pulsatile-flow LVADs on myocardial structure and function in this population... - Discovery of a novel tumour metastasis-promoting gene, NVM-1Wilko Thiele
University of Heidelberg, Medical Faculty Mannheim, Germany KIT Campus Nord, Institut für Toxikologie und Genetik, Karlsruhe, Germany
J Pathol 225:96-105. 2011..Up-regulation of FMNL2 and MT1E and down-regulation of TIMP4 and MHC-I is observed as a consequence of NVM-1 expression... - Serum metalloproteinases MMP-2, MMP-9, and metalloproteinase tissue inhibitors in patients are associated with arteriovenous fistula maturationEugene S Lee
Department of Surgery, University of California, Davis, Sacramento, CA, USA
J Vasc Surg 54:454-9; discussion 459-60. 2011..Metalloproteinase (MMP) activity, particularly MMP-2 and MMP-9, may be important for AVF maturation. We therefore sought to identify whether serum MMP levels could serve as a biomarker for predicting future successful AVF maturation... - [Changing trends of the expression of TIMP-4 in mouse ovary during pregnant and postpartum period]Shu Min Bu
Capital Institute of Physic Education, Beijing 100088, China
Zhongguo Ying Yong Sheng Li Xue Za Zhi 24:248-52. 2008..The changes of tissue inhibitor of metalloproteinase-4 (TIMP-4) expression in mouse ovary during pregnant and postpartum period were studied to investigate the role of TIMP-4 in corpus luteum (CL)... - Influence of LPS, TNF, TGF-ß1 and IL-4 on the expression of MMPs, TIMPs and selected cytokines in rat synovial membranes incubated in vitroAnna Hyc
Department of Histology and Embryology, Medical University of Warsaw, Chalubinskiego 5 St, PL02 004 Warsaw, Poland
Int J Mol Med 27:127-37. 2011..IL-1ß, TGF-ß1, MMP1a, MMP1b, MMP3, MMP9, MMP13, MMP14, TIMP1 and TIMP3 while the mRNA levels of MMP2, TIMP2 and TIMP4 were significantly decreased... - [Expression and significance of matrix metalloproteinase-1,9, tissue inhibitor of metalloproteinase-4 and extracellular matrix metalloproteinase inducer in the myocardium of congestive heart failure in patients with rheumatic heart diseases]Yuan Zhao
Department of Cardiothoracic Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China
Zhong Nan Da Xue Xue Bao Yi Xue Ban 34:790-5. 2009.... - Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi familiesRobert Wojciechowski
Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA
Invest Ophthalmol Vis Sci 51:4989-95. 2010..The genetic association of refractive error and polymorphisms in MMP and TIMP genes in Old Order Amish (AMISH) and Ashkenazi Jewish (ASHK) families was investigated... - MMP-9 gene ablation and TIMP-4 mitigate PAR-1-mediated cardiomyocyte dysfunction: a plausible role of dicer and miRNAParas Kumar Mishra
Department of Physiology and Biophysics, School of Medicine, University of Louisville, HSC A 1215, 500S Preston Street, Louisville, KY 40202, USA
Cell Biochem Biophys 57:67-76. 2010..There is selective inhibition of miR-376b and over-expression of miR-1, miR-26a, miR-30d, and miR-181c in MMP-9KO that are implicated in regulation of G-PCR and calcium handling... - Type-specific dysregulation of matrix metalloproteinases and their tissue inhibitors in end-stage heart failure patients: relationship between MMP-10 and LV remodellingYingjie Wei
Chinese Academy of Medical Sciences, Peking Union Medical College, Fuwai Hospital and Cardiovascular Institute, Key Laboratory of Cardiovascular Regenerative Medicine, Ministry of Health, Beijing, PR China
J Cell Mol Med 15:773-82. 2011..Our findings suggest that type-specific dysregulation of MMPs and TIMPs is associated with LV remodelling in end-stage HF patients, and MMP-10 may act as a novel biomarker for LV remodelling... - Atorvastatin modulates matrix metalloproteinase expression, activity, and signaling in abdominal aortic aneurysmsMorris Schweitzer
Department of Endocrinology, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Vasc Endovascular Surg 44:116-22. 2010..Matrix metalloproteinase 1, MMP2, MMP3, MMP9, Tissue Inhibitor of Metalloproteinase (TIMP2), TIMP3, TIMP4, or total Sma Mothers Against Decapentaplegia (SMAD2) expression did not differ with treatment... - Tissue inhibitor of metalloproteinase-4 is elevated in early-stage breast cancers with accelerated progression and poor clinical courseMichaelann Liss
Department of Hematology Oncology, Lankenau Hospital, 100 Lancaster Ave, Wynnewood, PA 19096, USA
Am J Pathol 175:940-6. 2009..Our findings prompt further evaluation of TIMP-4 as a simple prognostic marker that may help identify patients with early-stage breast cancer who could benefit from more aggressive treatment at diagnosis... - Meta-analysis of microarray gene expression studies on intracranial aneurysmsC Roder
Department of Neurosurgery, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
Neuroscience 201:105-13. 2012..differences in more than two studies and seven in more than three studies (BCL2, COL1A2, COL3A1, COL5A2, CXCL12, TIMP4, TNC)... - Matrix metalloproteinases 7 and 9 and their types 1 and 4 tissue inhibitors in tumors and plasma of patients with colorectal cancerE S Gershtein
N N Blokhin National Cncer Research Center, Russian Academy of Medical Sciences, Moscow
Bull Exp Biol Med 143:459-62. 2007..Plasma concentrations of the studied proteins did not correlate with their levels in the tumor, did not surpass the normal, and did not decease after removal of the primary tumor in the majority of patients... - Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2H F Bigg
Faculty of Dentistry and Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
J Biol Chem 272:15496-500. 1997..This new phenomenon may be of important physiological significance in modulating the cell surface activation of progelatinase A... - Expression of matrix metalloproteinase-26 and tissue inhibitor of matrix metalloproteinase-3 and -4 in endometrium throughout the normal menstrual cycle and alteration in users of levonorgestrel implants who experience irregular uterine bleedingNasser Chegini
Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida 32610, USA
Fertil Steril 80:564-70. 2003..To determine the expression of matrix metalloproteinase (MMP-26) and tissue inhibitor of MMP (TIMP) in the endometrium of women with normal menstrual cycles compared with users of levonorgestrel implants... - Expression of tissue inhibitor of metalloproteinase-4 in normal human corneal cells and experimental corneal neovascularizationDavid Hui Kang Ma
Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Ophthalmic Res 35:199-207. 2003..To study the expression of TIMP-4 in cultured corneal cells and in corneal neovascularization... - Imbalance between tissue inhibitor of metalloproteinase-4 and matrix metalloproteinases during acute myocardial [correction of myoctardial] ischemia-reperfusion injuryCostas J Schulze
Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2S2 Canada
Circulation 107:2487-92. 2003..MMP activities are also tightly regulated by tissue inhibitors of metalloproteinase (TIMPs). The change in TIMPs during acute myocardial ischemia-reperfusion injury is not clear... - Localization and expression of tissue inhibitor of metalloproteinase-4 in the immature gonadotropin-stimulated and adult rat ovaryKristen S Simpson
Department of Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
Biol Reprod 68:214-21. 2003..08). These findings indicate that TIMP-4 could play an important role in regulating MMPs in a localized manner in follicles and CL throughout the cycle... - Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 Heidi S T Kai
Canadian Institute of Health Research Group in Matrix Dynamics and the Department of Oral Biological and Medical Sciences, Faculty of Dentistry, Vancouver, British Columbia V6T 1Z3, Canada
J Biol Chem 277:48696-707. 2002.... - Remodeling of the left atrium in pacing-induced atrial cardiomyopathyBrian D Hoit
University Hospitals of Cleveland and Case Western Reserve University, OH, USA
Mol Cell Biochem 238:145-50. 2002..Thus, rapid pacing-induced atrial failure is associated with differential changes in MMP activity, an unchanged number of calcium pumps, and compensatory changes in the level of phospholamban... - Characterization of the murine Timp4 gene, localization within intron 5 of the synapsin 2 gene and tissue distribution of the mRNAOtto P Rahkonen
Department of Medical Biochemistry and Molecular Biology, University of Turku, FIN 20520 Turku, Finland
Biochim Biophys Acta 1577:45-52. 2002..define this role, modulation of TIMP-4 production by overexpression, aberrant expression and inactivation of the Timp4 gene in transgenic mice should be performed... - Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinase-4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3Jian Zhang
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, P R China
Mol Hum Reprod 8:659-66. 2002.... - Tissue inhibitor of metalloproteinases-4 (TIMP-4) gene expression is increased in human osteoarthritic femoral head cartilageWensheng Huang
Departments of Medicine, Research Center and Notre Dame Hospital of the Centre hospitalier de l université de Montréal CHUM, Montreal, Quebec, Canada H2L 4M1
J Cell Biochem 85:295-303. 2002..Increased TIMP levels in arthritic cartilage may not be a sufficiently effective defense against cartilage resorption by excessive multiple MMPs and aggrecanases... - Cardiac surgery increases the activity of matrix metalloproteinases and nitric oxide synthase in human heartsI Mayers
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
J Thorac Cardiovasc Surg 122:746-52. 2001..Heart function is variably impaired after cardiopulmonary bypass. We hypothesized that, similar to other myocardial injury states, cardiopulmonary bypass leads to enhanced activity of nitric oxide synthase and matrix metalloproteinases... - Detailed mapping of a congenital heart disease gene in chromosome 3p25E K Green
Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, Edgbaston, UK
J Med Genet 37:581-7. 2000..Candidate 3p25 CHD genes, such as PMCA2 (ATP2B2), fibulin 2, TIMP4, and Sec13R, were shown to map outside the target interval... - Invertebrate tissue inhibitor of metalloproteinase: structure and nested gene organization within the synapsin locus is conserved from Drosophila to humanN Pohar
Th Boveri Institut für Biowissenschaften, Lehrstuhl fur Genetik, Am Hubland, Wurzburg, D 97074, Germany
Genomics 57:293-6. 1999..We therefore speculate that the human TIMP4 gene will be located in intron V of the human synapsin-II gene on chromosome 3p25, and we present preliminary .. - Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectivelyT M Olson
Primary Children s Medical Center, University of Utah Health Sciences Center, Salt Lake City, Utah, 84112, USA
Genomics 51:148-51. 1998We have isolated genomic DNA containing the human tissue inhibitor of metalloproteinases-4 gene (TIMP4) and determined the structure of the exons comprising the gene... - Molecular cloning and expression analysis of the cDNA encoding rat tissue inhibitor of metalloproteinase-4I Wu
Laboratory for Surgical Research, Children s Hospital, Boston, Massachusetts, USA
Matrix Biol 16:339-42. 1998We have cloned and sequenced the cDNA encoding the rat tissue inhibitor of metalloproteinase 4 (TIMP-4)... - Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4M Wang
Department of Pediatrics, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
Oncogene 14:2767-74. 1997..TIMP-4 cDNA into MDA-MB-435 human breast cancer cells and studied the orthotopic growth of TIMP-4-transfected (TIMP4-435) versus control (neo-435) clones in the mammary fat pad of athymic nude mice... - Expression profiling of metalloproteinases and their inhibitors in cartilageLara Kevorkian
University of East Anglia, Norwich, UK
Arthritis Rheum 50:131-41. 2004..To profile the expression of all known members of the matrix metalloproteinase (MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal cartilage and cartilage from patients with osteoarthritis (OA)... - The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodelingBing Ma
Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 172:1872-81. 2004.... - Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasionYun Ge Zhao
Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, USA
Cancer Res 64:590-8. 2004..Higher levels of MMP-26 mRNA were also detected in DCIS cells by in situ hybridization... - Atrial extracellular matrix remodelling in patients with atrial fibrillationV Polyakova
Max Planck Institute for Heart and Lung Research, Core Lab for Molecular and Structural Biology, Bad Nauheim, Germany
J Cell Mol Med 12:189-208. 2008..with SR, collagen VI, matrix metalloproteinases MMP2, MMP9 and TIMP1 were significantly increased while TIMP3 and TIMP4 remained unchanged in all AF groups... - Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in miceMaarten Van Roy
Department of Molecular Biomedical Research, VIB, Ghent University, Technologiepark 927, 9052 Ghent Zwijnaarde, Belgium
Mol Cancer Ther 6:2563-71. 2007.... - Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3Carlo V Hojilla
Ontario Cancer Institute, 610 University Avenue Toronto, Ontario M5G2M9, Canada
J Cell Sci 120:1050-60. 2007..Recombinant TIMP1, TIMP3 and TIMP4 inhibited ductal elongation whereas TIMP2 promoted this process. - Intracellular targets of matrix metalloproteinase-2 in cardiac disease: rationale and therapeutic approachesRichard Schulz
Cardiovascular Research Group, Departments of Pediatrics and Pharmacology, University of Alberta, Edmonton, Alberta, Canada
Annu Rev Pharmacol Toxicol 47:211-42. 2007..MMP-2 proteolyzes specific targets within the cell to cause acute, reversible contractile dysfunction. Inhibitors of MMPs are discussed and their possible use for the therapy of acute heart injury caused by oxidative stress is examined... - Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reactionDylan N Clements
The Musculoskeletal Research Group, c o Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool, L69 3BX, UK
Arthritis Res Ther 8:R158. 2006..The expression of TIMP2 and TIMP4 was significantly reduced in canine OA cartilage... - Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumorSeakwoo Lee
Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA
Cell Res 16:750-8. 2006..The present study indicates that MMP-26 and TIMP-4 may play an integral role during the conversion of HGPIN to invasive cancer and may also serve as markers for early prostate cancer diagnosis... - Endometrial TIMP-4 mRNA is expressed in the stroma, while TIMP-4 protein accumulates in the epithelium and is released to the uterine fluidR Pilka
Department of Obstetrics and Gynecology, University Hospital, SE 221 84 Lund, Sweden
Mol Hum Reprod 12:497-503. 2006..MMP-26 is stored in epithelial cells in its active form, is not released spontaneously and is controlled by TIMP-4 in both stroma and uterine fluid... - Single nucleotide polymorphisms of tissue inhibitor of metalloproteinase genes in familial moyamoya diseaseHyun Seung Kang
Department of Neurosurgery, Konkuk University Hospital, Seoul, Korea
Neurosurgery 58:1074-80; discussion 1074-80. 2006..2-p26 and 17q25, respectively, which are the locations of familial moyamoya disease (FMMD) genes. We investigated single nucleotide polymorphisms of the TIMP2 and TIMP4 genes in FMMD patients to determine genetic predispositions. - Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RT-PCRPascale Lévy
Laboratoire de Génétique Moléculaire UPRES EA 3618, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris V, Paris, France
Mol Cancer 3:20. 2004..Plexiform neurofibromas can give rise to malignant peripheral nerve sheath tumors (MPNSTs), and the underlying molecular mechanisms are largely unknown... - Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26R Pilka
Department of Obstetrics and Gynaecology, University Hospital, S 221 85 Lund, Sweden
Mol Hum Reprod 10:641-50. 2004..Similarities in the cyclic patterns of TIMP-4 mRNA and MMP-26 mRNA, together with the fact that TIMP-4 is a potent inhibitor of MMP-26, suggest a functional relationship, and furthermore a role in human implantation... - Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: fine-tuning TIMP-4 for optimal inhibition of tumor necrosis factor-{alpha}-converting enzymeMeng Huee Lee
Department of Oncology, Cambridge University, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Cambridge CB2 2XY, United Kingdom
J Biol Chem 280:15967-75. 2005..Drawing together our previous experience in TACE-targeted mutagenesis by using TIMP-1 and -2 scaffolds, we have finally resolved the mystery of the selective sensitivity of TACE to TIMP-3... - Tissue inhibitor of metalloproteinases-4 is expressed in cervical cancer patientsFloria Lizarraga
Subdireccion de Investigacion Basica, Instituto Nacional de Cancerologia, DF Mexico
Anticancer Res 25:623-7. 2005..In particular, it has been shown that TIMP-1 and -2 levels are increased in cervical cancer patients. We analyzed, for the first time, TIMP-4 expression in cervical tumor samples... - CpG island methylation and expression of tumour-associated genes in lung carcinomaReinhard Dammann
AWG Tumour Genetics of the Medical Faculty, Martin Luther University, Halle Wittenberg, 06097 Halle Saale, Germany
Eur J Cancer 41:1223-36. 2005..In lung cancer cell lines, CpG island methylation was frequently detected for TIMP4 (64%), SOX18 (73%), EGF-like domain 7 (56%), CD105 (71%), SEMA2 (55%), RASSF1A (71%), p16 (56%) SLIT2 (100%) and .. - Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissuesA C P Riddick
Norfolk and Norwich University Hospital NHS Trust, Norwich NR4 7UY, UK
Br J Cancer 92:2171-80. 2005..expression of MMP2 and MMP23, maspin, and the protease inhibitors tissue inhibitor of metalloproteinase 3 (TIMP3), TIMP4 and RECK (reversion-inducing cysteine-rich protein with Kazal motifs) in the cancer specimens... - Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMPS Hernandez-Barrantes
Department of Pathology, Wayne State University, Detroit, Michigan 48201, USA
Biochem Biophys Res Commun 281:126-30. 2001..A balance between TIMP-2 and TIMP-4 may be a critical factor in determining the degradative potential of cells in normal and pathological conditions... - Imbalance of tissue inhibitors of metalloproteinases (TIMP) - 1 and - 4 serum levels, in patients with inflammatory bowel diseaseAndreas N Kapsoritakis
Department of Gastroenterology, University of Thessaly, School of Medicine, Larissa, Greece
BMC Gastroenterol 8:55. 2008..Since chronic inflammation is associated with tissue remodeling in inflammatory bowel disease (IBD), we evaluated serum TIMP-1 and TIMP-4 levels in IBD patients, in comparison with healthy controls (HC)... - Association of TIMP-4 gene polymorphism with the risk of osteoarthritis in the Korean populationH J Lee
Department of Pharmacology, College of Medicine, Kangwon National University, Hyoja, Chuncheon, 200 701, Republic of Korea
Rheumatol Int 28:845-50. 2008..We demonstrated that the C/T polymorphism which is located on the 3'-untranslational regions of the TIMP-4 gene might be associated with susceptibility to OA patients...
Research Grants
- Acuson Sequoia UltrasonographBrian Hoit; Fiscal Year: 2003....