Research Topics
Genomes and Genes
| SYNJ2BPSummaryGene Symbol: SYNJ2BP Description: synaptojanin 2 binding protein Alias: ARIP2, OMP25, activin receptor interacting protein 5, mitochondrial outer membrane protein 25, synaptojanin-2-binding protein Species: human Top Publications
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Publications
Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathwayTakashi Matsuzaki
Institute for Enzyme Research, The University of Tokushima, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
J Biol Chem 277:19008-18. 2002..We named the protein activin receptor-interacting protein 2 (ARIP2)...- Characterization of outer membrane vesicles from Brucella melitensis and protection induced in miceEric Daniel Avila-Calderón
Departamento de Microbiologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Prolongacion de Carpio y Plan de Ayala S N, Colonia Santo Tomas, 11340, Mexico, DF, Mexico
Clin Dev Immunol 2012:352493. 2012..melitensis 16?M; some of them are well-known Brucella immunogens such as SOD, GroES, Omp31, Omp25, Omp19, bp26, and Omp16... - VirB type IV secretory system does not contribute to Brucella suis' avoidance of human dendritic cell maturationElisabeth Billard
Centre d étude d agents Pathogènes et Biotechnologies pour la Santé CPBS Université Montpellier 1, Montpellier, France
FEMS Immunol Med Microbiol 53:404-12. 2008..Recently, we have established that several attenuated mutants of Brucella (rough, omp25, bvrR) are unable to control DCs maturation and thus effectively stimulate naïve T cells, which could be the .. - Importance of the Omp25/Omp31 family in the internalization and intracellular replication of virulent B. ovis in murine macrophages and HeLa cellsAna I Martín-Martín
Departamento de Microbiologia y Genetica, Edificio Departamental, Universidad de Salamanca, Plaza Doctores de la Reina s n, 37007 Salamanca, Spain
Microbes Infect 10:706-10. 2008The role of the outer membrane proteins of the Omp25/Omp31 family in invasiveness and intracellular survival of virulent B. ovis in phagocytes was analyzed. The absence of Omp25d or Omp22 in B... - Identification of protein-coding and intronic noncoding RNAs down-regulated in clear cell renal carcinomaGlauber Costa Brito
Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, SP, Brazil
Mol Carcinog 47:757-67. 2008..Lower levels of expression of SIN3B, TRIP3, SYNJ2BP and NDE1 (P < 0.02), and of intronic transcripts derived from SND1 and ACTN4 loci (P < 0... - Regulation of activin receptor-interacting protein 2 expression in mouse hepatoma Hepa1-6 cells and its relationship with collagen type IVHong Jun Zhang
Department of Immunology, School of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin Province, China
World J Gastroenterol 13:5501-5. 2007To investigate the regulation of activin receptor-interacting protein 2 (ARIP2) expression and its possible relationships with collagen type IV (collagen IV) in mouse hepatoma cell line Hepal-6 cells. - BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulenceLorea Manterola
Departamento de Microbiologia y Parasitologia, Universidad de Navarra, 31008 Pamplona, Spain
Infect Immun 75:4867-74. 2007..abortus two-component regulatory system BvrR/BvrS controls the expression of outer membrane proteins (Omp) Omp3a (Omp25) and Omp3b (Omp22)... - Brucella suis prevents human dendritic cell maturation and antigen presentation through regulation of tumor necrosis factor alpha secretionElisabeth Billard
INSERM U431, CPBS UMR CNRS 5236 UM1 UM2, F 34095 Montpellier, France
Infect Immun 75:4980-9. 2007..DCs failed to release tumor necrosis factor alpha (TNF-alpha), a defect involving the bacterial protein Omp25. Exogenous TNF-alpha addition to Brucella-infected DCs restored cell maturation and allowed them to present .. - Role of the Omp25/Omp31 family in outer membrane properties and virulence of Brucella ovisPaola Caro-Hernández
Departamento de Microbiologia y Genetica, Edificio Departamental, Universidad de Salamanca, Plaza Doctores de la Reina s n, 37007 Salamanca, Spain
Infect Immun 75:4050-61. 2007The genes coding for the five outer membrane proteins (OMPs) of the Omp25/Omp31 family expected to be located in the outer membrane (OM) of rough virulent Brucella ovis PA were inactivated to evaluate their role in virulence and OM .. - Development and evaluation of real-time polymerase chain reaction assays on whole blood and paraffin-embedded tissues for rapid diagnosis of human brucellosisMireille M Kattar
Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut 1107 2020, Lebanon
Diagn Microbiol Infect Dis 59:23-32. 2007..developed and compared targeting the 16S-23S internal transcribed spacer region (ITS) and the genes encoding for omp25 and omp31... - [ALL 98 strains of Brucella OMP25 gene is conservative in China]Wen Jing Wang
School of Biotechnology, Southern Medical University, Guangzhou 510515, China
Zhonghua Yu Fang Yi Xue Za Zhi 42:127-9. 2008To investigate the genetic polymorphism of OMP25 gene isolated from 116 Brucella strains, including 18 Brucella reference strains and 98 Chinese field strains. - Analysis of the occurrence and distribution of the Omp25/Omp31 family of surface proteins in the six classical Brucella speciesAna I Martín-Martín
Departamento de Microbiologia y Genetica, Edificio Departamental, Universidad de Salamanca, Plaza Doctores de la Reina s n, 37007 Salamanca, Spain
Vet Microbiol 137:74-82. 2009Members of the Omp25/Omp31 family of surface proteins were previously shown to participate in the virulence of some Brucella species and a different distribution of the seven proteins of this family among species could be related to the .. - A micropreparation of mitochondria from cells using magnetic beads with immunoaffinityYawei Ru
Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101318, China
Anal Biochem 421:219-26. 2012..located on the outer membrane of mitochondria, cytochrome b5 type B (CYB5B) and synaptojanin-2-binding protein (SYNJ2BP), were selected as candidates based on a survey of databases and the literature... - Brucella abortus choloylglycine hydrolase affects cell envelope composition and host cell internalizationMaria Ines Marchesini
Instituto de Investigaciones Biotecnológicas Instituto Tecnológico de Chascomús, Universidad Nacional de San Martin, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
PLoS ONE 6:e28480. 2011..of ?cgh cell envelope-associated proteins showed an altered expression of Omp2b and different members of the Omp25/31 family. These results were confirmed by Western blot analysis with monoclonal antibodies... - Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membraneSaori R Yoshii
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan
J Biol Chem 286:19630-40. 2011..Parkin mediates proteasome-dependent degradation of outer membrane proteins such as Tom20, Tom40, Tom70, and Omp25 of depolarized mitochondria... - Loop-mediated isothermal amplification assay targeting the omp25 gene for rapid detection of Brucella sppGuo zhen Lin
Key Laboratory of Veterinary Public Health of Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, China
Mol Cell Probes 25:126-9. 2011..This LAMP assay based on the sequence of highly repetitive omp25 gene was able to detect 9fg/?l Brucella spp... - Liposomal delivery of p-ialB and p-omp25 DNA vaccines improves immunogenicity but fails to provide full protection against B. melitensis challengeNicola J Commander
Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB, UK
Genet Vaccines Ther 8:5. 2010..melitensis using formulations of naked DNA vaccines encoding genes ialB and omp25. The present study was undertaken to further understand the immune response generated by the protective .. - The type IV secretion system affects the expression of Omp25/Omp31 and the outer membrane properties of Brucella melitensisYufei Wang
Department of Infectious Disease Control, Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing, China
FEMS Microbiol Lett 303:92-100. 2010..Many more products of OMPs, particularly different products of the Omp25/Omp31 family, were found to be altered in the virB mutant... - Expression and localization of activin receptor-interacting protein 2 in mouse tissuesHai Yan Liu
Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun, China
Gen Comp Endocrinol 161:276-82. 2009..Activin receptor-interacting protein 2 (ARIP2) has been recently identified in mouse tissues as a regulatory protein of activin signal transduction... - Comparative proteomics analyses reveal the virB of B. melitensis affects expression of intracellular survival related proteinsYufei Wang
Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing, China
PLoS ONE 4:e5368. 2009..The type IV secretion system encoded by the virB operon (virB) is involved in Brucella intracellular survival. However, the underlying molecular mechanisms, especially the target proteins affected by the virB, remain largely unclear... - Identification and characterization of human ARIP2 and its relation to breast cancerZhan Dong Li
Institute of Genetics and Cytology, Northeast Normal University, 5268 Renmin St, Changchun 130024, China
Cytokine 46:251-9. 2009..Previous studies showed that mouse ARIP2 can reduce activin signaling by interacting with activin type II receptors (ActRIIs); however, the activity of .. - The identification of two protective DNA vaccines from a panel of five plasmid constructs encoding Brucella melitensis 16M genesNicola J Commander
Department of Statutory and Exotic Bacterial Diseases, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK
Vaccine 25:43-54. 2007..From these experiments two protective DNA vaccines were identified: p-omp25 and p-ialB... - Characterization of a Brucella sp. strain as a marine-mammal type despite isolation from a patient with spinal osteomyelitis in New ZealandW L McDonald
Investigation and Diagnostic Centre, Biosecurity New Zealand, Ministry of Agriculture and Forestry, Ward St, Wallaceville, New Zealand
J Clin Microbiol 44:4363-70. 2006..by PCR, PCR-restriction fragment length polymorphism, and DNA sequencing of the bp26 gene; IS711; the omp genes omp25, omp31, omp2a, and omp2b; IRS-PCR fragments I, III, and IV; and five housekeeping gene fragments was conducted to .. - Characterization of isoforms of activin receptor-interacting protein 2 that augment activin signalingZ H Liu
The Institute for Enzyme Research, University of Tokushima, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
J Endocrinol 189:409-21. 2006..of ActRIIs with two independent PDZ proteins named activin receptor-interacting proteins 1 and 2 (ARIP1 and ARIP2). Overexpression of both ARIP1 and ARIP2 reduce activin-induced transcription... - Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane proteinY Nemoto
Department of Cell Biology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
EMBO J 18:2991-3006. 1999..Here we have identified and characterized a novel mitochondrial outer membrane protein, OMP25, with a single PDZ domain that specifically binds to a unique motif in the C-terminus of synaptojanin 2A... - Characterization of an immuno-dominant antigen in Brucella ovis and evaluation of its use in an enzyme-linked immunosorbent assayR Kittelberger
Central Animal Health Laboratory, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
Vet Microbiol 59:213-27. 1998..ovis outer membrane proteins Omp31 and Omp25, purified by preparative SDS-gel electrophoresis... - Evaluation of immunogenicity and protective activity in BALB/c mice of the 25-kDa major outer-membrane protein of Brucella melitensis (Omp25) expressed in Escherichia coliR A Bowden
Laboratoire de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, Nouzilly, France
J Med Microbiol 47:39-48. 1998The antibody response specific to the 25-kDa major outer-membrane protein (Omp25) of Brucella melitensis expressed in Escherichia coli was assessed in BALB/c mice. Groups of mice were immunised and boosted either with sonicated E... - Rapid identification of rough Brucella isolates by a latex coagglutination assay with the 25-kilodalton outer membrane protein and rough-lipopolysaccharide-specific monoclonal antibodiesR A Bowden
Laboratoire de Pathologie Infectieuse et Immunologie, INRA, Centre de Recherches de Tours, Nouzilly, France
Clin Diagn Lab Immunol 4:611-4. 1997..rough-lipopolysaccharide (R-LPS) monoclonal antibody (MAb) or an anti-Brucella 25-kDa outer membrane protein (Omp25) MAb. Slide agglutination tests were done for 68 strains of Brucella spp... - Humoral immune responses of Brucella-infected cattle, sheep, and goats to eight purified recombinant Brucella proteins in an indirect enzyme-linked immunosorbent assayJ J Letesson
URBM, Immunology Laboratory, FUNDP, Namur, Belgium
Clin Diagn Lab Immunol 4:556-64. 1997..On the basis of previous reports, we selected eight Brucella proteins (OMP36, OMP25, OMP19, OMP16, OMP10, p17, p15, and p39) as candidate antigens to be further evaluated... - Molecular and immunological characterization of the major outer membrane proteins of BrucellaA Cloeckaert
Laboratoire de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, Nouzilly, France
FEMS Microbiol Lett 145:1-8. 1996..Two genes code for the group 3 OMPs and are named omp25 and omp31. The predicted amino acid sequences of omp25 and omp31 share 34% identity... - Cloning, nucleotide sequence, and expression of the Brucella melitensis omp31 gene coding for an immunogenic major outer membrane proteinN Vizcaino
Laboratoire de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, Nouzilly, France
Infect Immun 64:3744-51. 1996..2% identity with the RopB OMP of Rhizobium leguminosarum bv. viciae 248 and 34.3% identity with Omp25 of B. abortus 544. As in Brucella spp... - Cloning of a Brucella melitensis group 3 antigen gene encoding Omp28, a protein recognized by the humoral immune response during human brucellosisL E Lindler
Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
Infect Immun 64:2490-9. 1996..had a primary amino acid sequence that was 43% similar to a previously described Brucella abortus group 3 Ag, Omp25 (P. de Wergifosse, P. Lintermans, J. N. Limet, and A. Cloeckaert, J. Bacteriol. 177:1911-1914, 1995)... - Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling proteinA Weins
Department of Medicine and Department of Anatomy and Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Cell Biol 155:393-404. 2001..We propose a dual role for myopodin as a structural protein also participating in signaling pathways between the Z-disc and the nucleus... - Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancersF Lin
Department of Pathology, School of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Am J Pathol 159:1603-12. 2001..Statistical analysis indicates that deletion of myopodin is highly correlated with the invasiveness of prostate cancers, and thus may hold promise as an important prognostic marker for prostate cancers... - Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3Naomi W Court
Cell Signalling Laboratory, Biochemistry and Molecular Biology M310, University of Western Australia, Western Australia 6009, Australia
Biochim Biophys Acta 1744:68-75. 2005..identify three additional PDZ domain-containing binding partners, Lin-7C, Scribble, and outer membrane protein 25 (OMP25). This latter protein is localised together with SAPK3 at the mitochondria but it is not a SAPK3 substrate... - Alternative splicing suggests extended function of PEX26 in peroxisome biogenesisSabine Weller
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Hum Genet 76:987-1007. 2005..PEX26-Mito) with PEX26 as its N-terminus and the targeting segment of a mitochondrial outer membrane protein (OMP25) at its C-terminus... - Identification and characterization of Xenopus OMP25Masafumi Inui
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8654, Japan
Dev Growth Differ 46:405-12. 2004This study describes the isolation of mitochondrial outer membrane protein 25 (OMP25) from Xenopus laevis and an analysis of its role in early development. X... - Novel factors in regulation of activin signalingKunihiro Tsuchida
Institute for Enzyme Research, The University of Tokushima, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
Mol Cell Endocrinol 225:1-8. 2004..We have studied the mechanism that ARIPs regulate cell surface expression and cellular localization of ActRIIs. ARIP2 interacts with both ActRIIs and RalBP1 (Ral binding protein 1) through different domains to dramatically change .. - DNA polymorphism in the omp25/omp31 family of Brucella spp.: identification of a 1.7-kb inversion in Brucella cetaceae and of a 15.1-kb genomic island, absent from Brucella ovis, related to the synthesis of smooth lipopolysaccharideNieves Vizcaino
Departamento de Microbiologia y Genetica, Edificio Departamental, Universidad de Salamanca, Plaza Doctores de la Reina s n, 37007 Salamanca, Spain
Microbes Infect 6:821-34. 2004Five genes homologous to the well-known omp25 and omp31 genes, that code for two major Brucella spp. outer membrane proteins (OMPs), have been detected in the genome of Brucella melitensis 16M and Brucella suis 1330... - Five-member gene family of Bartonella quintanaMichael F Minnick
Division of Biological Sciences, The University of Montana, Missoula 59812, USA
Infect Immun 71:814-21. 2003..pathogens were identified, including Bartonella henselae Pap31, Brucella Omp31, Agrobacterium tumefaciens Omp25, and neisserial opacity proteins (Opa). Family members expressed in vitro-synthesized proteins ranging from ca. 26... - Major outer membrane proteins of Brucella spp.: past, present and futureAxel Cloeckaert
Unité de Pathologie Aviaire et Parasitologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
Vet Microbiol 90:229-47. 2002..In the 1990s, two genes were identified coding for the group 3 proteins and were named omp25 and omp31. The predicted amino acid sequences of omp25 and omp31 share 34% identity... - The two-component system BvrR/BvrS essential for Brucella abortus virulence regulates the expression of outer membrane proteins with counterparts in members of the RhizobiaceaeC Guzman-Verri
Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, 304 3000 Heredia, Costa Rica
Proc Natl Acad Sci U S A 99:12375-80. 2002..bvrS transposon mutants with monoclonal antibodies showed all described major outer membrane proteins (Omps) but Omp25, a protein known to be involved in Brucella virulence... - Nucleotide sequence and expression of the gene encoding the major 25-kilodalton outer membrane protein of Brucella ovis: Evidence for antigenic shift, compared with other Brucella species, due to a deletion in the geneA Cloeckaert
Laboratoire de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, France
Infect Immun 64:2047-55. 1996The nucleotide sequences encoding the major 25-kDa outer membrane protein (OMP) (omp25 genes) of Brucella ovis 63/290, Brucella melitensis 16M, Brucella suis 1330, Brucella canis RM6/66, and Brucella neotomae 5K33 (all reference strains) .. - Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transductionM Gotthardt
Department of Molecular Genetics and Pathology, University of Texas Southwestern Medical Center, Dallas 75390-9046, USA
J Biol Chem 275:25616-24. 2000..They form the basis for the elucidation of the molecular pathways by which cells respond to the diversity of ligands that bind to these multifunctional receptors on the cell surface...
Research Grants
- BRUCELLA STATIONARY PHASE GENE EXPRESSION AND VIRULENCEROY ROOP; Fiscal Year: 2009..that require Hfq for their wild-type expression in this strain, and seven of these (sodC, ahpCD, virB, bvrRS, omp25, cydAB and znuA) are necessary for virulence in mice! RT-PCR analysis indicates that sodC, ahpCD, virB...
- BRUCELLA STATIONARY PHASE GENE EXPRESSION AND VIRULENCEROY M ROOP; Fiscal Year: 2010..that require Hfq for their wild-type expression in this strain, and seven of these (sodC, ahpCD, virB, bvrRS, omp25, cydAB and znuA) are necessary for virulence in mice! RT-PCR analysis indicates that sodC, ahpCD, virB...
- MOLECULAR MECHANISMS OF NEURONAL DIFFERENTIATIONWange Lu; Fiscal Year: 2010..Aim 1 will determine the role of Arip in neurogenesis in vivo. We generated Arip1 and Arip2 knockout mice and will determine their neurogenesis phenotypes...