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Genomes and Genes
| STARD13SummaryGene Symbol: STARD13 Description: StAR-related lipid transfer (START) domain containing 13 Alias: ARHGAP37, DLC2, GT650, 46H23.2, DLC-2, Rho GTPase activating protein on chromosome 13q12, deleted in liver cancer 2 protein, stAR-related lipid transfer protein 13 Species: human Top Publications
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Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinomaYick Pang Ching
Institute of Molecular Biology, University of Hong Kong, China
J Biol Chem 278:10824-30. 2003..In search of tumor suppressor genes in this region, here we have identified DLC2 (for deleted in liver cancer 2) at 13q12.3 encoding a novel Rho family GTPase-activating protein (GAP)...- Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activityThomas Ho Yin Leung
Department of Pathology, SH Ho Foundation Research Laboratories and Hong Kong Jockey Club Clinical Research Centre, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
Proc Natl Acad Sci U S A 102:15207-12. 2005The deleted in liver cancer 2 (DLC2) gene, located at chromosome 13q12.3, is a recently identified tumor suppressor gene... - Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13F J Couch
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA
Genomics 36:86-99. 1996..However, the presence of additional genes in the BRCA2 interval is suggested as groups of putative exons and hybrid selected clones that were transcribed in consistent orientations could be localized to common physical intervals... - Integrative genome-wide analysis reveals a robust genomic glioblastoma signature associated with copy number driving changes in gene expressionMarie de Tayrac
Faculty of Medicine, CNRS UMR 6061, Regulation of Transcription and Oncogenesis, IFR140 GFAS, Rennes, France
Genes Chromosomes Cancer 48:55-68. 2009..highlights a robust cis-acting DNA targeted genes signature that may be critical for glioblastoma progression, with two tumor suppressor genes PCDH9 and STARD13 that could be involved in tumor invasiveness and resistance to etoposide. - Deleted in liver cancer 1 controls cell migration through a Dia1-dependent signaling pathwayGerlinde Holeiter
Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
Cancer Res 68:8743-51. 2008..However, whether the loss of DLC1 or DLC2 is the cause of aberrant Rho signaling in transformed cells has not been investigated... - The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migrationDandan Zhong
Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, Singapore, Republic of Singapore
J Cell Sci 122:414-24. 2009..factor 1A1 (EF1A1) as a novel partner for the sterile alpha motif (SAM) domain of DLC1 but not the SAM domain of DLC2. The solution structure of DLC1 SAM revealed a new monomeric fold with four parallel helices, similar to that of .. - Mitogen-activated protein kinase inhibition induces translocation of Bmf to promote apoptosis in melanomaMatthew W VanBrocklin
Drug Development Department, Nevada Cancer Institute, Las Vegas, Nevada 89135, USA
Cancer Res 69:1985-94. 2009..In resistant cells, Bmf remained sequestered to the cytoskeleton through dynein light chain 2 (DLC2) binding... - START-GAP2/DLC2 is localized in focal adhesions via its N-terminal regionKatsuhisa Kawai
Graduate School of Life Science, University of Hyogo, Harima Science Garden City, Hyogo ken 978 1297, Japan
Biochem Biophys Res Commun 380:736-41. 2009START-GAP2, also termed as DLC2, is a START domain-containing RhoGAP and a negative regulator of RhoA and Cdc42... - Dynein light chain regulates axonal trafficking and synaptic levels of BassoonAnna Fejtova
Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
J Cell Biol 185:341-55. 2009..In this study, we report the direct interaction of Bassoon with dynein light chains (DLCs) DLC1 and DLC2, which potentially link PTVs to dynein and myosin V motor complexes... - CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progressionXiangfei Kong
Gene Research Center, Key Laboratory of Glycoconjugate Research Ministry of Public Health, Shanghai Medical College of Fudan University, Shanghai, P R China, 200032
J Biochem 146:417-27. 2009..analysis showed PAK1(174E) could be recruited to myosin V motor complex through binding to dynein light chain 2 (DLC2)... - Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosisManuel Comabella
Centre d esclerosi multiple de Catalunya, Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron, Edifici Escola d Infermeria 2 feminine planta, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
Arch Neurol 66:972-8. 2009..However, not all patients respond to interferon beta therapy, and to date there is a lack of surrogate markers that reliably correlate with responsiveness to interferon beta therapy in MS... - Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesisTai On Yau
Liver Cancer and Hepatitis Research Laboratory and SH Ho Foundation Research Laboratories, Department of Pathology, The University of Hong Kong, Hong Kong, China
PLoS ONE 4:e6566. 2009b>DLC2 (deleted in liver cancer 2), a Rho GTPase-activating protein, was previously shown to be underexpressed in human hepatocellular carcinoma and has tumor suppressor functions in cell culture models... - Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone--an array comparative genomic hybridization studyTarja Niini
Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Genes Chromosomes Cancer 49:132-43. 2010..Hypermethylation of both p16(INK4a) and p14(ARF) was found in 1/14 patients. An internal deletion of STARD13 was found in a region with common losses at 13q13.1... - Defining genetic determinants of the Metabolic Syndrome in the Framingham Heart Study using association and structural equation modeling methodsNora L Nock
Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106 USA
BMC Proc 3:S50. 2009..effects of CSMD1 diminished in Approach 3 when modeled simultaneously with six other genes, most notably CETP and STARD13, which were strongly associated with the Lipids and MetSyn factors, respectively... - DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migrationY Lin
Department of Biochemistry and Molecular Medicine University of California Davis, Sacramento, CA 95817, USA
Oncogene 29:3010-6. 2010..Although DLC2 shares a similar domain structure with that of DLC1, the function of DLC2 is not well characterized... - Genome-wide association study of intracranial aneurysm identifies three new risk lociKatsuhito Yasuno
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA
Nat Genet 42:420-5. 2010..2 (odds ratio (OR) = 1.22, P = 1.1 x 10(-12)), STARD13-KL on 13q13.1 (OR = 1.20, P = 2.5 x 10(-9)) and a gene-rich region on 10q24.32 (OR = 1.29, P = 1.2 x 10(-9))... - Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinomaLi Xiaorong
Department of General Surgery, The Third Affiliated Hospital of Central South University, Central South University, Tongzhipo Road, Changsha, Hunan Province, 410013, PR China
BMC Cancer 8:205. 2008b>DLC2, a unique RhoGAP, has been recently identified as a tumor suppressor gene in hepatocellular carcinoma (HCC)... - Early gene expression in human lymphocytes after gamma-irradiation-a genetic pattern with potential for biodosimetryA Turtoi
Research Centre Julich, Department of Safety and Radiation Protection, Laboratory of Radiation Biology, Germany
Int J Radiat Biol 84:375-87. 2008.... - Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dyneinS Naisbitt
Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Neurosci 20:4524-34. 2000..A yeast two-hybrid screen with GKAP isolated DLC2, a novel protein 93% identical to the previously cloned 8 kDa dynein light chain (DLC1)... - The 14-kDa dynein light chain-family protein Dlc1 is required for regular oscillatory nuclear movement and efficient recombination during meiotic prophase in fission yeastFutaba Miki
Kazusa DNA Research Institute, Kisarazu 292 0812, Japan
Mol Biol Cell 13:930-46. 2002..S. pombe contains a homolog of the 8-kDa dynein light chain, Dlc2. This class of dynein light chain, however, is not essential in either the vegetative or sexual phases. - Localization of dynein light chains 1 and 2 and their pro-apoptotic ligandsCatherine L Day
Department of Biochemistry, University of Otago, Dunedin, New Zealand
Biochem J 377:597-605. 2004..In vivo DLC2 is found exclusively as a component of the myosin V motor complex and Bmf binds DLC2 selectively... - Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cellsA A Morales
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Leukemia 18:41-7. 2004..Bcl-2 family member that is normally sequestered to myosin V motors by binding to the dynein light chain 2 (DLC2). Certain damage signals release Bmf, which then binds prosurvival Bcl-2 proteins and triggers apoptosis... - Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteinsGanachari M Nagaraja
Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA
Biochem Biophys Res Commun 313:654-65. 2004..The presence of various motifs in RhoGAP and its interaction with several other proteins suggest that the protein may regulate Rho signaling in multiple ways and possibly function in a Rho-independent manner... - Characterization of human ARHGAP10 gene in silicoMasuko Katoh
M and M Medical BioInformatics, Narashino 275 0022, Japan
Int J Oncol 25:1201-6. 2004..RICH1), ARHGAP18, ARHGAP19, ARHGAP20, ARHGAP21, ARHGAP22, ARHGAP23, ARHGAP24, ARHGAP25, ARHGAP26, STRAD13 (DLC2), HA-1, GMIP, PARG1, PIK3R1, PIK3R2, RACGAP1, and FNBP2... - Identification and characterization of ARHGAP27 gene in silicoYuriko Katoh
M and M Medical BioInformatics, Hongo 113 0033, Japan
Int J Mol Med 14:943-7. 2004..ARHGAP17 (RICH1), ARHGAP18, ARHGAP19, ARHGAP20, ARHGAP21, ARHGAP22, ARHGAP23, ARHGAP24, ARHGAP25, ARHGAP26, STARD13 (DLC2), HA-1, GMIP, PARG1, RACGAP1, PIK3R1, PIK3R2, and FNBP2 genes encode Rho/Rac/Cdc42-like GTPase activating (.. - Alternatively spliced exon B of myosin Va is essential for binding the tail-associated light chain shared by dyneinZsuzsa Hódi
Department of Biochemistry, Eotvos Lorand University, Budapest, Hungary
Biochemistry 45:12582-95. 2006..Fragments of the human myosin Va tail and the DLC2 isoform were expressed, and their complex formation was analyzed by pull-down assays, gel filtration, and .. - Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2Hongyan Li
Department of Chemistry and Open Laboratory of Chemical Biology, The University of Hong Kong, Pokfulam, Hong Kong, People s Republic of China
Proteins 67:1154-66. 2007The deleted in liver cancer 2 (DLC2) is a tumor suppressor gene, frequently found to be underexpressed in hepatocellular carcinoma... - The NMR structure of the murine DLC2 SAM domain reveals a variant fold that is similar to a four-helix bundleJamie J Kwan
Department of Biology, York University, Toronto, Ontario, Canada
BMC Struct Biol 7:34. 2007The tumor suppressor DLC2 (Deleted in Liver Cancer -2) participates in cell signaling at the mitochondrial membrane... - Characterization of the BH3 protein Bmf in Gallus gallus: identification of a novel chicken-specific isoformFrancisco Gómez-Esquer
Departamento de Ciencias de la Salud III, Universidad Rey Juan Carlos, Avenida de Atenas s n, Alcorcon, Madrid, Spain
Gene 407:21-9. 2008..subgroup of Bcl-2 family proteins, which is associated to myosin V motors by binding to the dynein light chain 2 (DLC2). It acts as a sentinel detecting intracellular damages on the main cytoskeletal structures... - START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphologyKatsuhisa Kawai
Graduate School of Life Science, University of Hyogo, Harima Science Garden City, Hyogo ken 678 1297, Japan
Biochem Biophys Res Commun 364:783-9. 2007..START-GAP3/DLC3 is a tumor suppressor gene similar to two other human START-GAPs known as DLC1 or DLC2. Although expression of START-GAP3/DLC3 inhibits the proliferation of cancer cells, its molecular function is not .. - StARD13(Dlc-2) RhoGap mediates ceramide activation of phosphatidylglycerolphosphate synthase and drug response in Chinese hamster ovary cellsGrant M Hatch
Manitoba Institute of Cell Biology, CancerCare Manitoba, Winnipeg, Manitoba, Canada R3E 0V9
Mol Biol Cell 19:1083-92. 2008..The promoter trap retrovirus was found integrated into intron 1-2 of the Dlc-2 (Stard13) RhoGap gene... - Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathwayThomas Ho Yin Leung
Department of Pathology, The University of Hong Kong, Hong Kong, China
Liver Int 30:1315-23. 2010Deleted in liver cancer 2 (DLC2) gene, a putative tumour suppressor gene, encodes a Rho GTPase-activating protein (RhoGAP) with GAP activity specific for RhoA...