SRC3

Summary

Gene Symbol: SRC3
Description: nuclear receptor coactivator 3
Alias: ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP, CBP-interacting protein, amplified in breast cancer 1 protein, class E basic helix-loop-helix protein 42, receptor-associated coactivator 3, steroid receptor coactivator protein 3, thyroid hormone receptor activator molecule 1
Species: human

Top Publications

  1. ncbi P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain
    Marco Lodrini
    Georg Speyer Haus, Institute for Biomedical Research, Paul Ehrlich Strasse 42 44, 60596 Frankfurt, Germany
    Nucleic Acids Res 36:1847-60. 2008
  2. ncbi The nuclear receptor coactivator AIB1 mediates insulin-like growth factor I-induced phenotypic changes in human breast cancer cells
    Annabell Oh
    Department of Oncology, Vincent T Lombardi Cancer Center, Georgetown University, Washington, District of Columbia 20057, USA
    Cancer Res 64:8299-308. 2004
  3. ncbi Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators
    Stephen J Demarest
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 415:549-53. 2002
  4. ncbi Amplified in breast cancer 1 expression in breast cancer
    M A Thorat
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Histopathology 53:634-41. 2008
  5. ncbi Overexpression of an N-terminally truncated isoform of the nuclear receptor coactivator amplified in breast cancer 1 leads to altered proliferation of mammary epithelial cells in transgenic mice
    Maddalena T Tilli
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Research Building, Room E307, 3970 Reservoir Road, Washington, D C 20057, USA
    Mol Endocrinol 19:644-56. 2005
  6. ncbi Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
    Ray Chang Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:3549-61. 2002
  7. ncbi Polymorphic repeat in AIB1 does not alter breast cancer risk
    C A Haiman
    Channing Laboratory, Department of Medicine, Harvard School of Public Health, 191 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 2:378-85. 2000
  8. ncbi Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene)
    S K Shirazi
    Department of Urology, Norris Cancer Center, University of Southern California, Los Angeles 90033, USA
    Clin Genet 54:102-3. 1998
  9. ncbi Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:2396-405. 2002
  10. ncbi Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways
    Ray Chang Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 15:937-49. 2004

Research Grants

  1. Pancreas Cancer Specialized Program of Research Excelle*
    Anton Wellstein; Fiscal Year: 2006
  2. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard Karas; Fiscal Year: 2009
  3. Activin receptor signaling in cardiac development.
    KATYA HENDERSON; Fiscal Year: 2002
  4. Vitamin D Receptor Coactivators in Keratinocytes
    Daniel Bikle; Fiscal Year: 2009
  5. STRUCTURE AND FUNCTION OF HISTONE ACETYLTRANSFERASES
    Ronen Marmorstein; Fiscal Year: 2003
  6. Nuclear cofactors in hormone signaling
    Hongwu Chen; Fiscal Year: 2010
  7. Nuclear cofactors in hormone signaling
    Hongwu Chen; Fiscal Year: 2010
  8. FUNCTIONS OF ESTROGEN RECEPTOR COACTIVATORS IN BREAST TI
    Meei Huey Jeng; Fiscal Year: 2003
  9. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine Gudas; Fiscal Year: 2009
  10. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine J Gudas; Fiscal Year: 2010

Detail Information

Publications155 found, 100 shown here

  1. ncbi P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain
    Marco Lodrini
    Georg Speyer Haus, Institute for Biomedical Research, Paul Ehrlich Strasse 42 44, 60596 Frankfurt, Germany
    Nucleic Acids Res 36:1847-60. 2008
    ..Our study discloses a new, complementary mechanism for the current model of coactivator recruitment to target gene promoters...
  2. ncbi The nuclear receptor coactivator AIB1 mediates insulin-like growth factor I-induced phenotypic changes in human breast cancer cells
    Annabell Oh
    Department of Oncology, Vincent T Lombardi Cancer Center, Georgetown University, Washington, District of Columbia 20057, USA
    Cancer Res 64:8299-308. 2004
    The nuclear receptor coactivator AIB1 (amplified in breast cancer 1) is overexpressed in human breast cancers and is required for estrogen signaling. However, the role of AIB1 in breast cancer etiology is not known...
  3. ncbi Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators
    Stephen J Demarest
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 415:549-53. 2002
    ..Our study uncovers a unique mechanism, called 'synergistic folding', through which p160 coactivators recruit CBP/p300 to allow transmission of the hormonal signal to the transcriptional machinery...
  4. ncbi Amplified in breast cancer 1 expression in breast cancer
    M A Thorat
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Histopathology 53:634-41. 2008
    The amplified in breast cancer 1 (AIB1), steroid receptor co-activator family member, acts as an oestrogen receptor (ER) co-activator...
  5. ncbi Overexpression of an N-terminally truncated isoform of the nuclear receptor coactivator amplified in breast cancer 1 leads to altered proliferation of mammary epithelial cells in transgenic mice
    Maddalena T Tilli
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Research Building, Room E307, 3970 Reservoir Road, Washington, D C 20057, USA
    Mol Endocrinol 19:644-56. 2005
    Amplified in breast cancer 1 (AIB1, also known as ACTR, SRC-3, RAC-3, TRAM-1, p/CIP) is a member of the p160 nuclear receptor coactivator family involved in transcriptional regulation of genes activated through steroid receptors, such as ..
  6. ncbi Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
    Ray Chang Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:3549-61. 2002
    ..these coactivators are members of the steroid receptor coactivator (SRC) family, SRC-1, TIF2/GRIP1/SRC-2, and pCIP/ACTR/AIB-1/RAC-3/TRAM-1/SRC-3...
  7. ncbi Polymorphic repeat in AIB1 does not alter breast cancer risk
    C A Haiman
    Channing Laboratory, Department of Medicine, Harvard School of Public Health, 191 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 2:378-85. 2000
    STATEMENT OF FINDINGS: We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort...
  8. ncbi Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene)
    S K Shirazi
    Department of Urology, Norris Cancer Center, University of Southern California, Los Angeles 90033, USA
    Clin Genet 54:102-3. 1998
  9. ncbi Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:2396-405. 2002
    ..Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 coactivators and the P-TEFb complex...
  10. ncbi Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways
    Ray Chang Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 15:937-49. 2004
    Although several lines of evidence have indicated that the activity of SRC-3/AIB1/ACTR/pCIP/RAC3/TRAM1 could be regulated by phosphorylation, an important question remained as to how different signaling pathways can act through limiting ..
  11. ncbi E6AP mediates regulated proteasomal degradation of the nuclear receptor coactivator amplified in breast cancer 1 in immortalized cells
    Aparna Mani
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Cancer Res 66:8680-6. 2006
    The steroid receptor coactivator oncogene, amplified in breast cancer 1 (AIB1; also known as ACTR/RAC-3/TRAM-1/SRC-3/p/CIP), is amplified and overexpressed in a variety of epithelial tumors...
  12. ncbi SUG-1 plays proteolytic and non-proteolytic roles in the control of retinoic acid target genes via its interaction with SRC-3
    Christine Ferry
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Unite Mixte de Recherche 7104, Boite Postale 10142, Illkirch 67404 Cedex, CU de Strasbourg, France
    J Biol Chem 284:8127-35. 2009
    ..This study provides new insights into how SUG-1 has a unique role in linking the transcription and degradation processes via its ability to interact with SRC-3...
  13. ncbi Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators
    Y Kodera
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    J Biol Chem 275:33201-4. 2000
    ..Our findings suggest that ligand binding may alter PPARgamma structure in a ligand type-specific way, resulting in distinct PPARgamma-coactivator interactions...
  14. ncbi The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor
    X Wu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 276:23962-8. 2001
    ..The nuclear receptor coactivator RAC3 (also known as AIB1/ACTR/pCIP/TRAM-1/SRC-3) is amplified in breast cancer cells, where it forms a complex with ..
  15. ncbi RAC-3 is a NF-kappa B coactivator
    S Werbajh
    Deparmento de Cs Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II, Argentina
    FEBS Lett 485:195-9. 2000
    ..Here we report a role for the nuclear receptor coactivator RAC3, in modulating NF-kappa B transactivation...
  16. ncbi Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2
    W Xie
    Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Endocrinol 13:2151-62. 1999
    ..In addition, we show that members of the p160 family of nuclear receptor coactivators, ACTR (activator of thyroid and retinoic acid receptors), GRIP1 (glucocorticoid receptor interacting protein 1), and SRC-..
  17. ncbi Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene
    T Sugiyama
    Department of Molecular Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 275:3446-54. 2000
    ..Finally, overexpression of GRIP1 or SRC-1 does not convert COUP-TFI from a transcriptional repressor into a transcriptional activator in HeLa cells...
  18. ncbi Genetic factors related to racial variation in plasma levels of insulin-like growth factor-1: implications for premenopausal breast cancer risk
    H Jernstrom
    Centre for Research in Women s Health, University of Toronto, 790 Bay Street, 7th Floor, Toronto, Ontario, M5G 1N8, Canada
    Mol Genet Metab 72:144-54. 2001
    ..Samples of DNA were used to genotype the women for known polymorphic variants in the IGF1, AIB1, and CYP3A4 genes...
  19. ncbi Association of NCOA3 polymorphisms with breast cancer risk
    Barbara Burwinkel
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Clin Cancer Res 11:2169-74. 2005
    The nuclear receptor coactivator 3 (NCOA3, also known as AIB1) is a coactivator of nuclear receptors like the estrogen receptor...
  20. ncbi The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment
    K D Senali Abayratna Wansa
    University of Queensland Centre for Molecular and Cellular Biology Institute for Molecular Bioscience, St Lucia, Queensland 4072, Australia
    J Biol Chem 277:33001-11. 2002
    ..Thus, the AF-1 domain plays a major role in Nur77-mediated transcriptional activation, cofactor recruitment, and intra- and intermolecular interactions...
  21. ncbi The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Amanda B Spurdle
    The Queensland Institute of Medical Research, Brisbane, Australia
    Cancer Epidemiol Biomarkers Prev 15:76-9. 2006
    This is by far the largest study of its kind to date, and further suggests that AIB1 does not play a substantial role in modifying the phenotype of BRCA1 and BRCA2 carriers...
  22. ncbi SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock
    Ray Chang Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell 129:1125-40. 2007
    SRC-3/AIB1 is an important growth coactivator whose activity should be tightly regulated since excess activation results in oncogenesis...
  23. ncbi Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1)
    Ping Yi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:9687-99. 2005
    Steroid receptor coactivator 3 (SRC-3/AIB1) interacts with steroid receptors in a ligand-dependent manner to activate receptor-mediated transcription...
  24. ncbi A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
    Y Kamei
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, 92093 0648, USA
    Cell 85:403-14. 1996
    ....
  25. ncbi Regulation of SRC-3 intercompartmental dynamics by estrogen receptor and phosphorylation
    Larbi Amazit
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Biol 27:6913-32. 2007
    The steroid receptor coactivator 3 gene (SRC-3) (AIB1/ACTR/pCIP/RAC3/TRAM1) is a p160 family transcription coactivator and a known oncogene...
  26. ncbi A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA
    M Watanabe
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0033, Japan
    EMBO J 20:1341-52. 2001
    ..These findings indicate that p72/p68 acts as an ER subtype-selective coactivator through ER alpha AF-1 by associating with the coactivator complex to bind its AF-2 through direct binding with SRA and the SRC-1/TIF2 family proteins...
  27. ncbi Somatic instability of the DNA sequences encoding the polymorphic polyglutamine tract of the AIB1 gene
    P Dai
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA
    J Med Genet 40:885-90. 2003
    b>AIB1 contains a polymorphic polyglutamine tract (poly Q) that is encoded by a trinucleotide CAG repeat. Previously there have been conflicting results regarding the effect of the poly Q tract length on breast cancer...
  28. ncbi The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
    J Torchia
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648, USA
    Nature 387:677-84. 1997
    ..p/CIP, NCoA-1 and CBP all contain related leucine-rich charged helical interaction motifs that are required for receptor-specific mechanisms of gene activation, and allow the selective inhibition of distinct signal-transduction pathways...
  29. ncbi RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2
    H Li
    Department of Pharmacology and Molecular Toxicology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0126, USA
    Proc Natl Acad Sci U S A 94:8479-84. 1997
    ..We report here the cloning and characterization of receptor-associated coactivator 3 (RAC3), a human transcriptional coactivator for steroid/nuclear receptors...
  30. ncbi Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
    H Chen
    Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, La Jolla 92037, USA
    Cell 90:569-80. 1997
    We report here the identification of a novel cofactor, ACTR, that directly binds nuclear receptors and stimulates their transcriptional activities in a hormone-dependent fashion...
  31. ncbi TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1
    A Takeshita
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 272:27629-34. 1997
    ..These results suggest that TRAM-1 is a coactivator that may exhibit its activity by interacting with subdomains of NRs other than the AF-2 region, in contrast to SRC-1/TIF2...
  32. ncbi Transcription factor-specific requirements for coactivators and their acetyltransferase functions
    E Korzus
    Howard Hughes Medical Institute, University of California San Diego UCSD, 9500 Gilman Drive, La Jolla, CA 92093 0648, USA
    Science 279:703-7. 1998
    ....
  33. ncbi AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
    S L Anzick
    Laboratory of Cancer Genetics, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Science 277:965-8. 1997
    ..b>AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose ..
  34. ncbi Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers
    Luna Kadouri
    Sharett Institute of Oncology, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Int J Cancer 108:399-403. 2004
    ..Genes involved in hormonal signal transduction are possible candidates. The AIB1 gene, an estrogen receptor (ER) coactivator, is frequently amplified in breast and ovarian tumors...
  35. ncbi Associations and interactions between Ets-1 and Ets-2 and coregulatory proteins, SRC-1, AIB1, and NCoR in breast cancer
    Eddie Myers
    Department of Surgery, Saint Vincent s University Hospital University College Dublin, Dublin 4, Ireland
    Clin Cancer Res 11:2111-22. 2005
    ..We investigated the mitogen-activated protein kinase-activated transcription factors, Ets, as possible interaction proteins for the coactivators SRC-1 and AIB1 and the corepressor NCoR in human breast cancer.
  36. ncbi Clinical implications of steroid receptor coactivator (SRC)-3 in uterine endometrial cancers
    Hideki Sakaguchi
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 1 1 Yanagido, Gifu City 501 1194, Japan
    J Steroid Biochem Mol Biol 104:237-40. 2007
    ..Steroid receptor coactivator-3 (SRC-3; AIB1, ACTR, RAC3, TRAM-1, and pCIP) is a member of the p160 family of coactivator for nuclear hormone receptors including estrogen ..
  37. ncbi Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities
    S S Koh
    Department of Pathology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 276:1089-98. 2001
    ..Because multiple coactivators are presumably required to mediate transcriptional activation of native genes in vivo, the low-NR conditions may provide a more physiologically relevant assay for coactivator function...
  38. ncbi The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome
    Xiaotao Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 124:381-92. 2006
    Steroid receptor coactivator-3 (SRC-3/AIB1) is an oncogene frequently amplified and overexpressed in breast cancers...
  39. ncbi Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer
    X Y Guan
    Laboratory of Cancer Genetics, National Center for Human Genome Research, NIH, Bethesda, Maryland 20892 4470, USA
    Cancer Res 56:3446-50. 1996
    ..Using this strategy, we have isolated three novel amplified genes (termed AIB1, AIB3, and AIB4) from a cDNA library constructed from the 20q amplified breast cancer cell line BT-474...
  40. ncbi Alleles of the estrogen receptor alpha-gene and an estrogen receptor cotranscriptional activator gene, amplified in breast cancer-1 (AIB1), are associated with quantitative calcaneal ultrasound
    M S Patel
    Department of Pediatrics Genetics, Hospital for Sick Children, Toronto, Ontario, Canada
    J Bone Miner Res 15:2231-9. 2000
    ..of peak bone mass, we studied alleles of two genes, estrogen receptor alpha (ER1) and amplified in breast cancer-1 (AIB1), for their association with QUS...
  41. ncbi The AIB1 glutamine repeat polymorphism is not associated with risk of breast cancer before age 40 years in Australian women
    Karen G Montgomery
    Cancer Genetics Laboratory, Victorian Breast Cancer Research Consortium, Peter MacCallum Cancer Centre, St, Andrews Place, East Melbourne, Victoria, Australia
    Breast Cancer Res 7:R353-6. 2005
    b>AIB1, located at 20q12, is a member of the steroid hormone coactivator family...
  42. ncbi SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4
    J C Wang
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 273:30847-50. 1998
    ..Thus, HNF4 is involved in the regulation of glucose homeostasis at several levels and along with the SRC-1, GRIP1, and p300 may play an important role in the pathophysiology of non-insulin-dependent diabetes mellitus...
  43. ncbi Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP
    Eric A Ortlund
    Department of Chemistry, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Nat Struct Mol Biol 12:357-63. 2005
    ..Our results indicate that hLRH-1's control of gene expression is mediated by phospholipid binding, and establish hLRH-1 as a novel target for compounds designed to slow breast cancer development...
  44. ncbi Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
    BMC Cancer 9:43. 2009
    ....
  45. ncbi The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation
    Hina Naeem
    Cancer Research Laboratories, London Regional Cancer Program, London, Ontario, Canada N6A 4L6
    Mol Cell Biol 27:120-34. 2007
    ..In the present study, we have established that recombinant p/CIP (p300/CBP interacting protein) is robustly methylated by CARM1 in vitro but not by other protein arginine methyltransferase family ..
  46. ncbi Bone morphogenetic proteins
    Di Chen
    School of Medicine and Dentistry, Department of Orthopaedics, University of Rochester, Rochester, NY 14642, USA
    Growth Factors 22:233-41. 2004
    ..BMP ligands, type IA and IB BMP receptors (BMPR-IA or ALK-3 and BMPR-IB or ALK-6) and type IA activin receptor (ActR-IA or ALK-2) (Koenig, B.B. et al...
  47. ncbi Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle
    T M Lovell
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, PO Box 228, Reading, Berkshire RG6 6AJ, UK
    J Endocrinol 186:447-55. 2005
    ..quantitative PCR was used to quantify pituitary expression of mRNAs encoding betaglycan, activin receptor (ActR) subtypes (type I, IIA), GnRH receptor (GnRH-R), LH beta subunit, FSH beta subunit and GAPDH...
  48. ncbi Differential expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and activin type-I and type-II receptors in preovulatory and prehierarchical follicles of the laying hen ovary
    T M Lovell
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, UK
    J Endocrinol 188:241-9. 2006
    ..Real-time quantitative PCR was used to quantify the expression of mRNA encoding betaglycan, activin receptor (ActR) subtypes (type-I, -IIA and -IIB) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH); receptor expression data ..
  49. ncbi A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi
    Bo Lu
    Parasitology Research Center, Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
    Infect Immun 76:3530-8. 2008
    ..In screening receptors important for nervous system repair, this parasite counterreceptor immunoprecipitation (PcIP) assay identified 7 to 11 polypeptides (molecular masses, 14 kDa to 55 kDa) that bound to the coreceptors of glial ..
  50. ncbi Gene expression and protein localisation for activin-A, follistatin and activin receptors in goat ovaries
    J R V Silva
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Endocrinol 183:405-15. 2004
    ..fixed in paraformaldehyde for immunohistochemical localisation of activin-A, follistatin, activin receptors IIA/B (ActR-IIA/B) and IA (ActR-IA) proteins or used to obtain samples to demonstrate mRNA expression of activin-A (betaA ..
  51. ncbi Steroid receptor coactivator expression throughout the menstrual cycle in normal and abnormal endometrium
    Christopher W Gregory
    Department of Pathology and Laboratory Medicine, Division of Reproductive Endocrinology and Infertility, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Clin Endocrinol Metab 87:2960-6. 2002
    ..the expression patterns of three coactivators, steroid receptor coactivator-1, amplified in breast cancer-1 (AIB1), and transcriptional intermediary factor-2 in human endometrium obtained prospectively from normal fertile women ..
  52. ncbi Bone morphogenetic proteins and their receptors: potential functions in the brain
    T Ebendal
    Department of Developmental Neuroscience, Uppsala University, Sweden
    J Neurosci Res 51:139-46. 1998
    ..brain is expressing high levels of bone morphogenetic protein receptor type II (BMPR-II), activin receptor type I (ActR-I), and activin receptor type IIA (ActR-II)...
  53. ncbi Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor
    K Hilden
    Department of Bacteriology and Immunology, University of Helsinki, Finland
    Blood 83:2163-70. 1994
    ..and the human fetal brain, which is, of the tissues screened by Northern blot analysis, the most abundant source of ActR-IIB RNA...
  54. ncbi Expression of activin A and its receptors in human pheochromocytomas
    J Liu
    Department of Pathology, PO Box 21, University of Helsinki, Finland
    J Endocrinol 165:503-8. 2000
    ..Both type I and type II activin receptor (ActR-I, ActR-IB and ActR-II) mRNA expression was also detectable in the pheochromocytoma tissues...
  55. ncbi Expression of gonadotropin and activin receptor messenger ribonucleic acid in human ovarian epithelial neoplasms
    T Minegishi
    Department of Obstetrics and Gynecology School of Medicine, Gunma University, Maebashi, Japan
    Clin Cancer Res 6:2764-70. 2000
    ..Northern blot analysis showed the presence of 3.0-kb type Ia ActR, 6.0- and 3.0-kb type IIa ActR, and 5...
  56. ncbi Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors
    C M Klinge
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    J Mol Endocrinol 33:387-410. 2004
    ..SRC-2 (glucocorticoid receptor interacting protein 1 (GRIP1)), SRC-3 amplified in breast cancer 1 (AIB1) and ACTR, cyclic AMP binding protein (CBP), and steroid receptor RNA activator (SRA), corepressors nuclear receptor co-..
  57. ncbi BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells
    Enkeleda Nakuci
    Dana Farber Cancer Institute and Harvard Medical School, 44 Binney St, Boston, MA 02115, USA
    Exp Cell Res 312:3120-31. 2006
    ..we show that: (1) BRCA1-IRIS forms complex with two of the nuclear receptor co-activators, namely, SRC1 and SRC3 (AIB1) in an ERalpha-independent manner...
  58. ncbi Cell survival effect of activin against heat shock stress on OVCAR3
    J Fukuda
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Japan
    Life Sci 63:2209-20. 1998
    ..All of inhibin subunits and ActR Ia, IIa and IIb mRNA were amplified by RT-PCR in OVCAR3...
  59. ncbi Expression of nuclear receptors and cofactors in human endometrium and myometrium
    Annika Vienonen
    Department of Cell Biology, Medical School, University of Tampere, Tampere, Finland
    J Soc Gynecol Investig 11:104-12. 2004
    ..To study the expression of nuclear receptors and cofactors in human endometrium and myometrium in proliferative and secretory phases of the menstrual cycle...
  60. ncbi Actinorhodopsin genes discovered in diverse freshwater habitats and among cultivated freshwater Actinobacteria
    Adrian K Sharma
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    ISME J 3:726-37. 2009
    ..of these findings, and many studies that show Actinobacteria are common inhabitants of lakes, we predicted that ActR genes would likely be present in other freshwater habitats and among the genomes of cultivated Actinobacteria...
  61. ncbi Chromosome arm 20q gains and other genomic alterations in esophageal squamous cell carcinoma, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization
    Yoshifumi Fujita
    Department of Digestive Surgery, Department of Hygiene, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 0841, Japan
    Hepatogastroenterology 50:1857-63. 2003
    ..of the study presented here was to analyze the chromosomal aberrations and to determine the numbers of copies of AIB1, BTAK, DcR3 and E2F1 as putative target genes on chromosome 20q as well as their expression and relation to ..
  62. ncbi Gene amplification and expression of the steroid receptor coactivator SRC3 (AIB1) in sporadic breast and endometrial carcinomas
    M Glaeser
    Department of Gynecology and Obstetrics, Heinrich-Heine-University, Duesseldorf, Germany
    Horm Metab Res 33:121-6. 2001
    Steroid receptor coactivator 3 (SRC3) functions as a coactivator for nuclear receptor mediated transcriptional activation...
  63. ncbi Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements
    Robert F Gillespie
    Molecular Biology Program, Weill Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA
    J Biol Chem 282:33421-34. 2007
    ..However, the ability of RARgamma and/or RXRalpha to recruit pCIP (AIB1/ACTR/RAC-3/TRAM-1/SRC-3) and p300 to a RARE did correlate with RA-associated transcription of target mRNAs...
  64. ncbi Gonadotrophins modulate hormone secretion and steady-state mRNA levels for activin receptors (type I, IIA, IIB) and inhibin co-receptor (betaglycan) in granulosa and theca cells from chicken prehierarchical and preovulatory follicles
    Tristan M Lovell
    School of Biological Sciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AJ, UK
    Reproduction 133:1159-68. 2007
    ..We recently identified divergent expression of mRNAs encoding activin receptors (ActR) and inhibin co-receptor betaglycan in chicken follicles at different stages of maturation...
  65. ncbi Expression of cAMP response element binding protein (CREB)-binding protein (CBP) and the implication in retinoic acid-inducible transcription activation in human salivary gland adenocarcinoma cell line HSG
    S Kyakumoto
    Department of Biochemistry, Iwate Medical University School of Dentistry, Chuodori, Morioka, Iwate, Japan
    Endocr Res 29:277-89. 2003
    ..proteins represented by steroid receptor coactivator-1 (SRC-1)/NCoA1 and p300/CBP cointegrator protein (p/CIP)/ACTR. In order to investigate the relationship of CBP to the RA signaling in a human salivary gland (HSG) adenocarcinoma ..
  66. ncbi Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression
    Yuhui Yuan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 67:8032-42. 2007
    ..estrogen or in the presence of estrogen antagonists tamoxifen or ICI 182780; second, amplified in breast cancer 1 (AIB1), a cancer overexpressed transcriptional coactivator, was hyperphosphorylated, which made AIB1 a better coactivator ..
  67. ncbi Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases
    Thomas Piechulek
    Department of Pharmacology and Toxicology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Biol Chem 280:38923-31. 2005
    ..but not PLCgamma(1), was markedly activated in intact cells by constitutively active Rac1(G12V), Rac2(G12V), and Rac3(G12V) but not by Cdc42(G12V) and RhoA(G14V)...
  68. ncbi A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor
    Dionys Weber
    Lehrstuhl für Physiologische Chemie II, Theodor Boveri Institut für Biowissenschaften Biozentrum der Universität Würzburg, Am Hubland, D 97074 Wurzburg, Germany
    BMC Struct Biol 7:6. 2007
    ..In addition they act as high-affinity receptors for activins but are also low-affinity receptors for BMPs. ActR-II and ActR-IIB therefore represent an interesting example how affinity and specificity might be generated in a ..
  69. ncbi Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis
    K Verschueren
    Laboratory of Molecular Biology Celgen, University of Leuven, Belgium
    Mech Dev 52:109-23. 1995
    Activins exert their effects by inducing heteromeric complexes of either of two different type I receptors, ActR-I or ActR-IB, and either of two type II receptors, ActR-II or ActR-IIB...
  70. ncbi Direct activation of phospholipase C-epsilon by Rho
    Michele R Wing
    Department of Pharmacology, The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:41253-8. 2003
    ..In contrast, little effect was observed with the other Rho family members Rac1, Rac2, Rac3, and Cdc42...
  71. ncbi Effect of low-dose tamoxifen on steroid receptor coactivator 3/amplified in breast cancer 1 in normal and malignant human breast tissue
    Line L Haugan Moi
    Institute of Medicine, University of Bergen, Hormone Laboratory, Haukeland University Hospital, Bergen, Norway
    Clin Cancer Res 16:2176-86. 2010
    ..the gene expression of the steroid receptor coactivators SRC-1, SRC-2/transcription intermediary factor 2, and SRC-3/amplified in breast cancer 1 (AIB1) and the growth factor receptor HER-2/neu under three tamoxifen dose regimens.
  72. ncbi Hypoplasia of pancreatic islets in transgenic mice expressing activin receptor mutants
    T Yamaoka
    Otsuka Department of Clinical and Molecular Nutrition, School of Medicine, The University of Tokushima, Tokushima City, 770, Japan
    J Clin Invest 102:294-301. 1998
    ..and postnatal development of islets, transgenic mice expressing a dominant negative form of activin receptor (dn-ActR) or a constitutively active form of activin receptor (ActR-T206D) in islets were generated together with the ..
  73. ncbi CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions
    Georgios Giamas
    Department of Medical Oncology, Imperial College London, Hammersmith Hospital Campus, London, UK
    Nucleic Acids Res 37:3110-23. 2009
    Oncogenesis in breast cancer often requires the overexpression of the nuclear receptor coactivator AIB1/SRC-3 acting in conjunction with estrogen receptor-alpha (ERalpha)...
  74. ncbi Differential expression of activin subunits, activin receptors and follistatin genes in bovine oocytes and preimplantation embryos
    K Yoshioka
    Laboratories of Theriogenology, National Institute ofAnimal Health, Tsukuba, Ibaraki, Japan
    Reprod Fertil Dev 10:293-8. 1998
    ..The presence of inhibin subunits (alpha, betaA and betaB), activin binding protein follistatin and activin receptors (ActR-I, ActR-IB, ActR-II and ActR-IIB) mRNA transcripts in bovine oocytes and preimplantation embryos was examined by ..
  75. ncbi Inhibin-activin receptor subunit gene expression in ovarian tumors
    Peter J Fuller
    Prince Henry s Institute of Medical Research and Monash University, Department of Obstetrics and Gynecology, Monash Medical Center, Clayton, Victoria 3168, Australia
    J Clin Endocrinol Metab 87:1395-401. 2002
    ..as consisting of either betaglycan or p120 in association with the type II or type I activin receptor subunits (ActR), respectively...
  76. ncbi The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival
    Xian Chen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 24:1917-34. 2010
    Nuclear receptor coactivator 1 [NCOA1/steroid receptor coactivator (SRC)-1] and NCOA3 (SRC-3/AIB1/ACTR) constitute two thirds of the SRC (steroid receptor coactivator) family...
  77. ncbi Tissue- and gene-specific recruitment of steroid receptor coactivator-3 by thyroid hormone receptor during development
    Bindu D Paul
    Laboratory of Gene Regulation and Development, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:27165-72. 2005
    ..metamorphosis on thyroid hormone (T3) as a model, we have investigated the role of steroid receptor coactivator 3 (SRC3) in gene activation by thyroid hormone receptor (TR) in vivo...
  78. ncbi Selective inhibition of cell growth by activin in SNU-16 cells
    Young Il Kim
    East West Medical Research Institute, Kyung Hee University, Seoul, South Korea
    World J Gastroenterol 12:3000-5. 2006
    ..To investigate whether activin regulates the cell proliferation of human gastric cancer cell line SNU-16 through the mRNA changes in activin receptors, Smads and p21(CIP1/WAF1)...
  79. ncbi Molecular cloning of xSRC-3, a novel transcription coactivator from Xenopus, that is related to AIB1, p/CIP, and TIF2
    H J Kim
    College of Pharmacy, Chonnam National University, Kwangju, South Korea
    Mol Endocrinol 12:1038-47. 1998
    ..It belongs to a growing coactivator family that includes a steroid receptor coactivator amplified in breast cancer (AIB1), p300/ CREB-binding protein (CBP)-interacting protein (p/ CIP), and transcriptional intermediate factor 2 (TIF2)...
  80. ncbi Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas
    Silke Lassmann
    Institut fur Pathologie, Universitatsklinikum Freiburg, Breisacherstr 115a, 79110, Freiburg, Germany
    J Mol Med (Berl) 85:293-304. 2007
    ..preferentially altered in CIN-type tumors and included DNA amplifications of eight genes on chromosome 20q (TOP1, AIB1, MYBL2, CAS, PTPN1, STK15, ZNF217, and CYP24), two genes on chromosome 13q (BRCA2 and D13S25), and three genes on ..
  81. ncbi Effect of activin A on in vitro development of rat preantral follicles and localization of activin A and activin receptor II
    J Zhao
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands
    Biol Reprod 65:967-77. 2001
    ..In addition, gene expression for activin and activin receptor type II (ActR II) was demonstrated in both the oocytes and the somatic cells using the reverse transcription-polymerase chain ..
  82. ncbi Regulation of human estrogen receptor alpha-mediated gene transactivation in Saccharomyces cerevisiae by human coactivator and corepressor proteins
    Grant A Bitter
    BitTech, Inc, Westlake Village, CA 91361, USA
    J Steroid Biochem Mol Biol 103:189-95. 2007
    ..SRC2 potentiated transactivation two- to three-fold while SRC3 potentiated transactivation five- to eight-fold...
  83. ncbi Expression of activin receptor II and IIB mRNA isoforms in mouse reproductive organs and oocytes
    T C Wu
    Department of Obstetrics and Gynecology, UCLA School of Medicine 90024
    Mol Reprod Dev 38:9-15. 1994
    ..In the present study, we examined the isoform mRNA expression of both activin receptor type II (ActR-II) and type IIB (ActR-IIB) genes in mouse reproductive organs, cumulus-oocyte complexes (COCs), and ovulated ..
  84. ncbi Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors
    L Attisano
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Cell 68:97-108. 1992
    We have cloned ActR-IIB, which encodes four new activin receptor isoforms belonging to the protein serine/threonine kinase receptor family...
  85. ncbi Steroid hormone receptors and coregulators in endocrine-resistant and estrogen-independent breast cancer cells
    Nanna Sarvilinna
    Department of Cell Biology, Medical School, University of Tampere, Finland
    Int J Cancer 118:832-40. 2006
    ..and silencing mediator for retinoid acid and thyroid hormone receptors (SMRT) and amplified in breast cancer-1 (AIB1) expression increased in anti-estrogen-resistant cells...
  86. ncbi Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells
    Paul D Upton
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s and Papworth Hospitals, Cambridge CB2 2QQ, UK
    J Biol Chem 284:15794-804. 2009
    ..Conversely, activin receptor type II (ActR-II) contributed more to BMP9-mediated Smad2 activation...
  87. ncbi Effects of three groin compression methods on patient discomfort, distress, and vascular complications following a percutaneous coronary intervention procedure
    Linda L Chlan
    School of Nursing, University of Minnesota, 5 160 Weaver Densford Hall, 308 Harvard Street SE, Minneapolis, MN 55455, USA
    Nurs Res 54:391-8. 2005
    Incidence of vascular complications (VCs) after sheath removal following a percutaneous coronary intervention procedure (PCIP) vary widely by the compression method used to achieve femoral artery hemostasis.
  88. ncbi Steroid receptor coactivator-3 and activator protein-1 coordinately regulate the transcription of components of the insulin-like growth factor/AKT signaling pathway
    Jun Yan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 66:11039-46. 2006
    ..Taken together, our results clearly show that SRC-3 and AP-1 can coordinately regulate the transcription of multiple components in the IGF/AKT pathway to ensure ligand-independent cell proliferation and survival of cancer cells...
  89. ncbi Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor
    M Jeyakumar
    Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA
    Biochemistry 47:7465-76. 2008
    ..RXRalpha heterodimer, and fluorescein-labeled NR interaction domains of coactivator SRC3 or corepressor NCoR (fluorescence acceptors)...
  90. ncbi A dual-acceptor time-resolved Föster resonance energy transfer assay for simultaneous determination of thyroid hormone regulation of corepressor and coactivator binding to the thyroid hormone receptor: Mimicking the cellular context of thyroid hormone act
    M Jeyakumar
    Department of Chemistry, University of Illinois, Urbana, IL 61801, USA
    Anal Biochem 386:73-8. 2009
    ..We could measure independently, in separate assays, both the recruitment of SRC3 (steroid receptor coactivator 3, a transcriptional coactivator) and the dissociation of NCoR (nuclear receptor ..
  91. ncbi Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas
    B M Ghadimi
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Pathol 154:525-36. 1999
    ..Copy number increases on chromosome 20q were validated with a probe specific for the nuclear receptor coactivator AIB1 that maps to chromosome 20q12...
  92. ncbi Regulation of TGF-(beta) signalling by N-acetylgalactosaminyltransferase-like 1
    Patrick Herr
    Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Development 135:1813-22. 2008
    ..experiments showed that xGalntl-1 interferes with the activity of the common TGF-beta type II receptor ActR-IIB in vivo...
  93. ncbi Analysis of ligand-dependent recruitment of coactivator peptides to RXRbeta in a time-resolved fluorescence resonance energy transfer assay
    Deborah K Stafslien
    Invitrogen Discovery Sciences, Madison, Wisconsin 53719, USA
    Mol Cell Endocrinol 264:82-9. 2007
    ..Several peptides including D22, PGC1alpha, SRC3-2, PRIP/RAP250 and SRC1-4 also formed a complex with RXRbeta LBD in the presence of all-trans retinoic acid (at-RA) ..
  94. ncbi Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin
    J Carcamo
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Mol Cell Biol 14:3810-21. 1994
    ..Here we identify a new type I receptor for activin, ActR-IB, whose kinase domain is nearly identical to that of the recently cloned TGF-beta type I receptor, T beta R-I...
  95. ncbi Activation of signalling by the activin receptor complex
    L Attisano
    Cell Biology and Genetics Program and Howard Hughes Medical Institute, New York 10021 USA
    Mol Cell Biol 16:1066-73. 1996
    ..Using the ActR-IB and ActR-IIB receptor isoforms, we have investigated the mechanism of activin receptor activation...
  96. ncbi Src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of Bcl-2
    V Boudny
    Department of Medicine and Biosystemic Science, Graduate School of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Fukuoka 812 8582, Japan
    Br J Cancer 86:463-9. 2002
    ..As compared with parental HAG-1 cell line, v-src-transfected HAG/src3-1 cells became 5.9 and 7.0-fold sensitive to taxotere for 2 and 24-h exposure, respectively...
  97. ncbi Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis
    Shao Qing Kuang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 65:7993-8002. 2005
    Amplified in breast cancer 1 (AIB1; steroid receptor coactivator-3, p/CIP, RAC3, ACTR, TRAM-1, or NCoA-3) is a transcriptional coactivator for nuclear receptors and certain other transcription factors and is a newly defined oncogene ..
  98. ncbi Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5
    H Nishitoh
    Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170, Japan
    J Biol Chem 271:21345-52. 1996
    ..In addition to these receptors, osteogenic protein-1 (OP-1, also known as BMP-7) binds to activin type I receptor (ActR-I) as well as activin type II receptors (ActR-II and ActR-IIB)...
  99. ncbi Crystal structures of the Streptomyces coelicolor TetR-like protein ActR alone and in complex with actinorhodin or the actinorhodin biosynthetic precursor (S)-DNPA
    A R Willems
    Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    J Mol Biol 376:1377-87. 2008
    ..actA is divergently transcribed from actR, which encodes a TetR-like transcriptional repressor...
  100. ncbi Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland
    Holly E Barker
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia
    BMC Dev Biol 8:94. 2008
    ..Here we investigated the influence of DEAF-1 on human and mouse mammary epithelial cells both in vitro and in vivo and identified a potential target gene...
  101. ncbi The prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome
    Andrew R Green
    Division of Pathology, School of Molecular Medical Sciences, Nottingham University Hospitals NHS and University of Nottingham, Nottingham, UK
    Breast Cancer Res Treat 110:427-37. 2008
    ..This study investigates the pattern of expression of the steroid receptor co-regulators NCOA1/SRC1, NCOA3/RAC3, NCOR2/SMRT, and CBP/p300 in breast cancer...

Research Grants68

  1. Pancreas Cancer Specialized Program of Research Excelle*
    Anton Wellstein; Fiscal Year: 2006
    ..Project 3 focuses on recent findings that inhibition of the nuclear receptor coactivator AIB1 within pancreas cancer cells and adjacent endothelium may block signaling from multiple growth factors to enhance ..
  2. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard Karas; Fiscal Year: 2009
    ..The transcriptional effects of ERs depend on receptor interacting proteins, including SRC3, a member of the family of co-activator proteins...
  3. Activin receptor signaling in cardiac development.
    KATYA HENDERSON; Fiscal Year: 2002
    ..through the following three aims: (1) Generation of a conditional "knock-out" allele for the activin receptor ActR-IIA and analysis of the efficiency of this alleles in vivo...
  4. Vitamin D Receptor Coactivators in Keratinocytes
    Daniel Bikle; Fiscal Year: 2009
    ..critical for formation of SRC complexes, only SRC 2 and 3 have been found in keratinocytes, and of these two SRC3 plays the dominant role in the processes we have examined...
  5. STRUCTURE AND FUNCTION OF HISTONE ACETYLTRANSFERASES
    Ronen Marmorstein; Fiscal Year: 2003
    ..human, Drosophilia and Arabadopsis], yeast ESA1 (yESA1), and human PCAF (hPCAF), CBP/p300, TAFII250, Tip60, ACTR, and SRC-1...
  6. Nuclear cofactors in hormone signaling
    Hongwu Chen; Fiscal Year: 2010
    ..Indeed our previous studies indicate that ACTR, one of the p160/SRC cofactors, can function as a coactivator for both ERa and the activator E2Fs, therefore ..
  7. Nuclear cofactors in hormone signaling
    Hongwu Chen; Fiscal Year: 2010
    ..Indeed our previous studies indicate that ACTR, one of the p160/SRC cofactors, can function as a coactivator for both ERa and the activator E2Fs, therefore ..
  8. FUNCTIONS OF ESTROGEN RECEPTOR COACTIVATORS IN BREAST TI
    Meei Huey Jeng; Fiscal Year: 2003
    Overexpression of estrogen receptor alpha (ERalpha) transcriptional regulators, such as AIB1 (coactivator amplified in breast cancer-1), has been demonstrated in many ERalpha-positive human breast cancer cell lines and tumors...
  9. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine Gudas; Fiscal Year: 2009
    ..assays; overexpression or reduced expression of key transcriptional regulatory proteins such as pCIP (SRC3), EZH2, SUZ12, and JMJD3 in F9 and ES Wt and RAR1, 2, and 3 null cells; and deletion of DNA regulatory ..
  10. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine J Gudas; Fiscal Year: 2010
    ..immunoprecipitation) assays;overexpression or reduced expression of key transcriptional regulatory proteins such as pCIP (SRC3), EZH2, SUZ12, and JMJD3 in F9 and ES Wt and RAR1, 2, and 3 null cells;and deletion of DNA regulatory ..
  11. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard H Karas; Fiscal Year: 2010
    ..The transcriptional effects of ERs depend on receptor interacting proteins, including SRC3, a member of the family of co-activator proteins...
  12. VASCULAR ESTROGEN RECEPTOR SIGNALING PATHWAYS
    Richard Karas; Fiscal Year: 2009
    ..The transcriptional effects of ERs depend on receptor interacting proteins, including SRC3, a member of the family of co-activator proteins...
  13. DNA SEQUENCES IMPACT ESTROGEN AND ANTIESTROGEN ACTIVITY
    CAROLYN KLINGE; Fiscal Year: 2006
    ..by binding to different ERE sequences modulates ER interaction with coactivators SRC-1, SRC-2 (GRIP1), SRC-3 (AIB1), PRMT, and SRA; ERE regulated ER-coactivator interaction in turn modulates acetylation of histones H3 and H4, and ..
  14. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine J Gudas; Fiscal Year: 2010
    ..immunoprecipitation) assays;overexpression or reduced expression of key transcriptional regulatory proteins such as pCIP (SRC3), EZH2, SUZ12, and JMJD3 in F9 and ES Wt and RAR, , and null cells;and deletion of DNA regulatory elements ..
  15. Understanding the Effects of Cadmium on Breast Cancer Cell Growth
    Maggie Louie; Fiscal Year: 2007
    ..e. cycD1, c-myc and CTD) and non classical ER target genes ("non-ER") target genes (i.e. cyclin E1, cdk2 and ACTR). This suggests that in addition to the classical ER pathway, cadmium may activate an alternate signaling mechanism...
  16. Roles of SRC-3 in Development and Disease
    Jianming Xu; Fiscal Year: 2009
    ..Of particular note, genetic ablation of SRC3 in mice inhibits prostate cancer progression, arresting tumors in a well-differentiated state...
  17. Roles of SRC-3 in Development and Disease
    Jianming Xu; Fiscal Year: 2010
    ..Of particular note, genetic ablation of SRC3 in mice inhibits prostate cancer progression, arresting tumors in a well-differentiated state...
  18. Vitamin D Receptor Coactivators in Keratinocytes
    DANIEL DAVID BIKLE; Fiscal Year: 2010
    ..Of the three SRC proteins critical for formation of SRC complexes, SRC3 plays the dominant role in keratinocytes...
  19. Assays for Estrogen and Progesterone Receptor Antagonists
    David Shapiro; Fiscal Year: 2007
    ..an HTS assay for compounds that interfere with binding of the co-activators SRC1 and Amplified in Breast Cancer 1 (AIB1) to ERE-E2: ER complexes. 3...
  20. Pancreas Cancer Specialized Program of Research Excelle*
    Anton Wellstein; Fiscal Year: 2007
    ..Project 3 focuses on recent findings that inhibition of the nuclear receptor coactivator AIB1 within pancreas cancer cells and adjacent endothelium may block signaling from multiple growth factors to enhance ..
  21. Rac protein in hematopoietic cell survival and function
    David A Williams; Fiscal Year: 2010
    ..Rac (including the related Rac1, Rac2 and Rac3 proteins), Cdc42 and RhoA represent the best studied members of the Rho family of small GTPases...
  22. Rac protein in hematopoietic cell survival and function
    David Williams; Fiscal Year: 2009
    ..Rac (including the related Rac1, Rac2 and Rac3 proteins), Cdc42 and RhoA represent the best studied members of the Rho family of small GTPases...
  23. Immunoproteomics and detection of viral diseases
    Michael Boyle; Fiscal Year: 2004
    ..studies we have demonstrated the ability to use a single antibody-coated antigen capture and transfer reagent (ACTR) to detect model antigens, with good sensitivity, using surface enhanced laser desorption ionization time-of-flight ..
  24. Rac protein in hematopoietic cell survival and function
    David Williams; Fiscal Year: 2007
    ..Rac (including the related Rac1, Rac2 and Rac3 proteins), Cdc42 and RhoA represent the best studied members of the Rho family of small GTPases...
  25. Rac protein in hematopoietic cell survival and function
    David Williams; Fiscal Year: 2007
    ..Rac (including the related Rac1, Rac2 and Rac3 proteins), Cdc42 and RhoA represent the best studied members of the Rho family of small GTPases...
  26. FUNCTIONS OF CYCLIN D1 IN BREAST CANCER
    Emmett Schmidt; Fiscal Year: 2007
    ..MMTV-cyclin D1 will be crossed with MMTV-AIB1 transgenic mice to genetically test the role of cyclin D1/ER interactions...
  27. IDENTIFYING MODIFYING GENES IN BRCA1 MUTATION CARRIERS
    Katherine Nathanson; Fiscal Year: 2005
    ..Finally, there is preliminary data from several association studies, looking at HRAS, APC, the androgen receptor, AIB1, hRad51 and NAT2, which demonstrate that certain alleles of these genes modify penetrance in BRCA1 mutation ..
  28. Role of coactivators in cell growth and tumorigenesis
    Hongwu Chen; Fiscal Year: 2010
    ..b>ACTR/AIB1 has been found to have abnormally high levels in many types of human cancers, including breast cancer...
  29. Role of coactivators in cell growth and tumorigenesis
    Hongwu Chen; Fiscal Year: 2007
    ..b>ACTR/AIB1 has been found to have abnormally high levels in many types of human cancers, including breast cancer...
  30. Rac GTPases in the Mammalian Brain Development
    Chia Yi Kuan; Fiscal Year: 2010
    ..This approach cannot distinguish between Rac1 and its closely related isoform Rac3, and may interfere with the functions of other Rho GTPases such as Cdc42...
  31. REGULATION AND FUNCTION OF NUCLEAR RECEPTOR COACTIVATORS
    J Don Chen; Fiscal Year: 2002
    ..laboratory has recently identified and cloned a new member of the nuclear receptor coactivator family termed RAC3, which is also known as AIB1, p/CIP, ACTR, and TRAM-1...
  32. Rac GTPases in the Mammalian Brain Development
    Chia Yi Kuan; Fiscal Year: 2009
    ..This approach cannot distinguish between Rac1 and its closely related isoform Rac3, and may interfere with the functions of other Rho GTPases such as Cdc42...