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Genomes and Genes
| SNTB2SummaryGene Symbol: SNTB2 Description: syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) Alias: D16S2531E, EST25263, SNT2B2, SNT3, SNTL, 59 kDa dystrophin-associated protein A1 basic component 2, beta-2-syntrophin, dystrophin-associated protein A1, 59kD, basic component 2, syntrophin-3 Species: human Top Publications
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Publications
Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinasesC Lumeng
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
Nat Neurosci 2:611-7. 1999..Our data suggest that MAST205 and SAST link the dystrophin/utrophin network with microtubule filaments via the syntrophins...- Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactionsA Hogan
Department of Cellular and Molecular Medicine, Center for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
J Biol Chem 276:26526-33. 2001..Collectively, our results suggest that gamma 1-syntrophin participates in regulating the subcellular localization of DGK-zeta to ensure correct termination of diacylglycerol signaling... - The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapsesR A Garcia
Unit on Molecular Neurobiology, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 97:3596-601. 2000..As discussed, the interactions found between receptor tyrosine kinases and MAGUKs at neuronal synapses may have important implications for activity-dependent plasticity... - The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relativesA H Ahn
Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 271:2724-30. 1996.... - Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteinsS H Gee
Department of Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
J Neurosci 18:128-37. 1998..Collectively, our data suggest that syntrophins link NaChs to the actin cytoskeleton and the extracellular matrix via dystrophin and the DAPC... - A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosisPierre Chagnon
Division of Medical Genetics, Hopital Ste Justine, Centre Hospitalier Universitaire Mère Enfant, Universite de Montreal, Quebec, Canada
Am J Hum Genet 71:1443-9. 2002..Cirhin is preferentially expressed in embryonic liver, is predicted to localize to mitochondria, and contains WD repeats, which are structural motifs frequently associated with molecular scaffolds... - Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variantsGeoffrey M Goellner
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
Ann N Y Acad Sci 986:461-71. 2003..Our data suggest that PISP is a transiently interacting partner of the PMCA b-splice forms that may play a role in their sorting to or from the plasma membrane... - Deficiency of the syntrophins and alpha-dystrobrevin in patients with inherited myopathyK J Jones
Institute for Neuromuscular Research, The Children s Hospital at Westmead, Locked Bag 4001, NSW 2145, Westmead, Australia
Neuromuscul Disord 13:456-67. 2003.... - Embryonic expression patterns of the Drosophila dystrophin-associated glycoprotein complex orthologsLinda C Dekkers
Laboratory of Developmental Neurobiology, Department of Molecular and Cell Biology, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
Gene Expr Patterns 4:153-9. 2004..e. muscles of the body wall and around the gut... - Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24A H Ahn
Program in Neuroscience, Harvard Medical School, Boston, MA 02115
Proc Natl Acad Sci U S A 91:4446-50. 1994..with the GenBank expressed sequence tag (EST) data base has identified a relative from human skeletal muscle, EST25263, which is probably a human homologue of the published mouse syntrophin 2... - Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interactionZhongjian Chen
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 281:12414-20. 2006..This direct interaction may provide new information about the regulation of alpha1D-AR signaling and the role of syntrophins in modulating G protein-coupled receptor function... - TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemiaJennifer L Costantini
Department of Immunology, Biochemistry and Medical Genetics, University of Manitoba, 415 Apotex Centre, 750 McDermot Ave, Winnipeg, MB, R3E 0T5
Blood 114:4703-12. 2009..These findings identify TAPP2 as a novel link between PI3K signaling and the cytoskeleton with potential relevance for leukemia progression... - Dystrobrevin dynamics in muscle-cell signalling: a possible target for therapeutic intervention in Duchenne muscular dystrophy?Derek J Blake
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Neuromuscul Disord 12:S110-7. 2002..This article discusses the function of dystrobrevin in muscle and reviews its suitability as a therapeutic target for treating patients with Duchenne and Becker muscular dystrophies... - NotI flanking sequences: a tool for gene discovery and verification of the human genomeAlexey S Kutsenko
Center for Genomics and Bioinformatics, Karolinska Institute, 171 77 Stockholm, Sweden
Nucleic Acids Res 30:3163-70. 2002.... - The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complexChrista Buechler
Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
Biochem Biophys Res Commun 293:759-65. 2002.... - Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretionT Ort
Department of Internal Medicine, Section of Endocrinology, School of Nursing, Yale University School of Medicine, New Haven, CT 06520 8020, USA
EMBO J 20:4013-23. 2001..Thus, stimulation of insulin secretion might promote the mobilization of secretory granules by inducing the dissociation of ICA512 from beta2-syntrophin-utrophin complexes and the cleavage of the ICA512 cytoplasmic tail by mu-calpain... - Differential targeting of components of the dystrophin complex to the postsynaptic membraneS Marchand
Biologie Cellulaire des Membranes, Institut Jacques Monod, UMR 7592, CNRS Universités Paris 6, Paris 7, 2 place Jussieu, 75251 Paris Cedex 05, France
Eur J Neurosci 13:221-9. 2001..This study provides the first evidence for a separate targeting of the various components of the dystrophin-associated protein complex and a step-by-step assembly at the postsynaptic membrane... - The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cellsT Ort
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Eur J Cell Biol 79:621-30. 2000..Thus, we propose that ICA512, through beta2-syntrophin and nNOS, links secretory granules with the actin cytoskeleton and signaling pathways involving nitric oxide... - Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophinM E Adams
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
J Cell Biol 150:1385-98. 2000..Thus, alpha-syntrophin has an important role in synapse formation and in the organization of utrophin, acetylcholine receptor, and acetylcholinesterase at the neuromuscular synapse... - Chromosomal sublocalization of the transcribed human telomere repeat binding factor 2 gene and comparative mapping in the mouseA Y Sakaguchi
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284, USA
Somat Cell Mol Genet 24:157-63. 1998..gene is situated by itself in a newly defined "bin" on chromosome 8 one crossover distal to Psm10 and Sntb2. Human TERF2 and mouse Terf2 are therefore part of a large evolutionarily conserved linkage group comprised of at .. - Interaction of neuronal nitric-oxide synthase with alpha1-syntrophin in rat brainA Hashida-Okumura
Division of Protein Metabolism, Institute for Protein Research, Osaka University, 3 2 Yamada Oka, Suita, Osaka 565 0871, Japan
J Biol Chem 274:11736-41. 1999..These results indicate that nNOS in brain interacts with alpha1-syntrophin in specific neurons of the SCN and paraventricular nucleus and that this interaction might play a physiological role in functions of these neurons... - Influence of whole arm loss of chromosome 16q on gene expression patterns in oestrogen receptor-positive, invasive breast cancerDaniela Hungermann
Institute of Pathology, University of Munster, Germany
J Pathol 224:517-28. 2011..are associated with decreased expression of a number of candidate genes located on 16q (eg CDA08, CGI-128, SNTB2, NQO1, SF3B3, KIAA0174, ATBF1, GABARAPL2, KARS, GCSH, MBTPS1 and ZDHHC7) in breast carcinomas with a low degree of ..