serotonin transporter

Summary

Gene Symbol: serotonin transporter
Description: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Alias: 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, 5-hydroxytryptamine transporter, 5HT transporter, Na+/Cl- dependent serotonin transporter, sodium-dependent serotonin transporter, solute carrier family 6 member 4
Species: human

Top Publications

  1. ncbi 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
  2. ncbi Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
    Science 301:386-9. 2003
  3. ncbi A susceptibility gene for affective disorders and the response of the human amygdala
    Ahmad R Hariri
    Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:146-52. 2005
  4. ncbi Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety
    Tomoko Mizuno
    Tohoku University Graduate School of Medicine, Sendai, Japan
    J Psychosom Res 60:91-7. 2006
  5. ncbi Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting
    Marian J Bakermans-Kranenburg
    Centre for Child and Family Studies, Leiden University, PO Box 9555, NL 2300 RB Leiden, The Netherlands
    Soc Cogn Affect Neurosci 3:128-34. 2008
  6. ncbi Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531
    J R Wendland
    Mol Psychiatry 11:224-6. 2006
  7. ncbi Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
    Andreas Heinz
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Nat Neurosci 8:20-1. 2005
  8. ncbi Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans
    Eva Kosek
    Osher Center for Integrative Medicine, Stockholm Brain Institute, Department of Clinical Neuroscience, Karolinska Institutet, Sweden
    Mol Pain 5:37. 2009
  9. ncbi 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 150:271-81. 2009
  10. ncbi Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, United Kingdom
    Biol Psychiatry 63:852-7. 2008

Research Grants

  1. 5-HT transporter function: Interaction of antidepressants and hormones
    Alan Frazer; Fiscal Year: 2010
  2. DORSAL RAPHE NUCLEUS SEROTONIN NEURONS IN ALCOHOLISM
    Mark Underwood; Fiscal Year: 2009
  3. DORSAL RAPHE NUCLEUS SEROTONIN NEURONS IN ALCOHOLISM
    Mark D Underwood; Fiscal Year: 2010
  4. PET IMAGING OF SEROTONIN TRANSPORTERS IN THE BRAIN
    Hank F Kung; Fiscal Year: 2010
  5. Communication between platelet SERT and plasma 5HT
    Fusun Kilic; Fiscal Year: 2009
  6. Communication between platelet SERT and plasma 5HT
    Fusun Kilic; Fiscal Year: 2010
  7. Communication between platelet SERT and plasma 5HT
    Fusun Kilic; Fiscal Year: 2009
  8. The Norepinephrine Transporter as a Novel Target for a Bone Anabolic Treatment
    Florent Elefteriou; Fiscal Year: 2009
  9. The Norepinephrine Transporter as a Novel Target for a Bone Anabolic Treatment
    Florent Elefteriou; Fiscal Year: 2010
  10. Cocaine Use and Monoamine Function
    Leonard L Howell; Fiscal Year: 2010

Detail Information

Publications223 found, 100 shown here

  1. ncbi 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
    Carriers of the short allele of a functional 5' promoter polymorphism of the serotonin transporter gene have increased anxiety-related temperamental traits, increased amygdala reactivity and elevated risk of depression...
  2. ncbi Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
    Science 301:386-9. 2003
    ..A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful life events on depression...
  3. ncbi A susceptibility gene for affective disorders and the response of the human amygdala
    Ahmad R Hariri
    Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:146-52. 2005
    A common regulatory variant (5-HTTLPR) in the human serotonin transporter gene (SLC6A4), resulting in altered transcription and transporter availability, has been associated with vulnerability for affective disorders, including anxiety ..
  4. ncbi Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety
    Tomoko Mizuno
    Tohoku University Graduate School of Medicine, Sendai, Japan
    J Psychosom Res 60:91-7. 2006
    The objective of this study was to verify the hypothesis that variation of the serotonin transporter gene promoter region (5-HTTLPR) is associated with sensitivity to stress.
  5. ncbi Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting
    Marian J Bakermans-Kranenburg
    Centre for Child and Family Studies, Leiden University, PO Box 9555, NL 2300 RB Leiden, The Netherlands
    Soc Cogn Affect Neurosci 3:128-34. 2008
    ..We examined the role of serotonin transporter (5-HTT) and oxytocin receptor (OXTR) genes in explaining differences in sensitive parenting in a community ..
  6. ncbi Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531
    J R Wendland
    Mol Psychiatry 11:224-6. 2006
  7. ncbi Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
    Andreas Heinz
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Nat Neurosci 8:20-1. 2005
    Major depression is conditionally linked to a polymorphism of the human serotonin transporter gene (SLC6A4)...
  8. ncbi Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans
    Eva Kosek
    Osher Center for Integrative Medicine, Stockholm Brain Institute, Department of Clinical Neuroscience, Karolinska Institutet, Sweden
    Mol Pain 5:37. 2009
    ..The serotonin transporter (5-HTT) is a key regulator of serotonin metabolism and availability and its gene harbors several known ..
  9. ncbi 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 150:271-81. 2009
    ..There remains the possibility that the variant influences the NEO personality questionnaire measure of Neuroticism. However, a large, well-powered primary study is required to test this hypothesis directly and adequately...
  10. ncbi Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, United Kingdom
    Biol Psychiatry 63:852-7. 2008
    We evaluated the magnitude of the reported associations between amygdala activation and the serotonin transporter gene linked polymorphic region (5-HTTLPR) and the likely effect size of this relationship.
  11. ncbi Gender effects on association of serotonin transporter gene polymorphism with symptoms of central fatigue
    N V Maluchenko
    Biological Faculty, M V Lomonosov Moscow State University, Moscow, Russia
    Bull Exp Biol Med 147:462-5. 2009
    ..Thus, we confirmed that the degree of central fatigue depends on the function of the serotonin system and revealed gender differences in adaptive capacities of carriers of different variants of serotonin transporter.
  12. ncbi Ethnic differences in the serotonin transporter polymorphism (5-HTTLPR) in several European populations
    Tatyana Noskova
    Institute of Biochemistry and Genetics, Ufa Scientific Centre, RAS, 71 Octyabrya Avenue, Ufa, 450054, Russia
    Prog Neuropsychopharmacol Biol Psychiatry 32:1735-9. 2008
    The serotonin transporter (5-HTT) is a protein that has a major role in divergent psychiatric disorders, personality traits and behaviors, by regulating serotonergic synaptic function...
  13. ncbi Emotion specific modulation of automatic amygdala responses by 5-HTTLPR genotype
    Udo Dannlowski
    Department of Psychiatry, University of Munster, Albert Schweitzer Str 11, 48149 Munster, Germany
    Neuroimage 53:893-8. 2010
    A functional polymorphism in the serotonin transporter gene (5-HTTLPR) has been reported to modulate amygdala responsiveness to negative environmental cues...
  14. ncbi Serotonin transporter gene polymorphism in irritable bowel syndrome
    Cengiz Pata
    Department of Internal Medicine, Faculty of Medicine, University of Mersin, Turkey
    Am J Gastroenterol 97:1780-4. 2002
    ..is secreted, it is effectively cleansed from the neuronal gap by means of a high affinity substance called serotonin transporter (SERT), which depends on the Na+ and Cl- ions localized in the presynaptic neuronal membranes...
  15. ncbi The symptomatic profile of panic disorder is shaped by the 5-HTTLPR polymorphism
    Tina B Lonsdorf
    Department of Clinical Neuroscience, Psychology Section, Karolinska Institutet, Stockholm, Sweden
    Prog Neuropsychopharmacol Biol Psychiatry 33:1479-83. 2009
    The short allele of a functional polymorphism (5-HTTLPR) in the serotonin transporter (5-HTT) promoter is associated with reduced serotonin transporter expression, lower in vivo 5-HTT binding, higher neuroticism and amygdala reactivity ..
  16. ncbi Serotonin transporter genetic polymorphisms and harm avoidance in the Chinese
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taiwan, ROC
    Psychiatr Genet 12:165-8. 2002
    ..Two polymorphisms of the serotonin transporter (5HTT-LPR, serotonin transporter-linked polymorphism region; 5HTT-VNTR, variable number tandem repeat ..
  17. ncbi Meta-analysis of serotonin transporter polymorphisms and affective disorders
    Francis E Lotrich
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Psychiatr Genet 14:121-9. 2004
    Polymorphisms in the promoter region (5-HTTLPR) of the serotonin transporter and a variable number of tandem repeats polymorphism in the second intron have been widely studied...
  18. ncbi Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population
    Tadashi Umekage
    Department of Psychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neurosci Lett 337:13-6. 2003
    b>Serotonin transporter gene may play a critical role in a regulation of mood and other aspects of mental status...
  19. ncbi The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population
    Kerang Zhang
    Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, 030001, PR China
    J Affect Disord 114:224-31. 2009
    b>Serotonin transporter (5-HTT) and 5-HT receptor (5-HTR) involved in the neurotransmission of 5-HT may play an important role in the development of major depression disorder (MDD)...
  20. ncbi Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion
    Stefan Wüst
    Department of Theoretical and Clinical Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 34:972-82. 2009
    A key regulator of serotonergic neurotransmission is the serotonin transporter (5-HTT) and a common 5HTT gene promoter polymorphism, termed 5HTTLPR, is associated with phenotypes related to anxiety and depression...
  21. ncbi Polymorphisms of the HTR1a allele are linked to frontal brain electrical asymmetry
    Andrew W Bismark
    University of Arizona, Tucson, AZ 85721 0068, United States
    Biol Psychol 83:153-8. 2010
    ..In conclusion, variation in HTR1a can influence trait level brain activity, which may ultimately be indicative of risk for psychopathology...
  22. ncbi Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli
    Christopher G Beevers
    Department of Psychology, University of Texas at Austin, Texas 78712, USA
    J Abnorm Psychol 118:670-81. 2009
    A deletion polymorphism in the serotonin transporter-linked polymorphic region (5-HTTLPR) has been associated with vulnerability to affective disorders, yet the mechanism by which this gene confers vulnerability remains unclear...
  23. ncbi No relationship between the ins del polymorphism of the serotonin transporter promoter and pain perception in fibromyalgia patients and healthy controls
    Stephane Potvin
    Service of Neurosurgery, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada
    Eur J Pain 14:742-6. 2010
    ..study, we sought to investigate, for the first time in humans, the relationships between the serotonin transporter promoter region (5-HTTLPR) polymorphism and experimentally-induced pain perception/inhibition in healthy ..
  24. ncbi Sleep quality varies as a function of 5-HTTLPR genotype and stress
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 69:621-4. 2007
    ..Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function...
  25. ncbi Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task
    Turhan Canli
    Department of Psychology and Graduate Program in Genetics, Stony Brook University, Stony Brook, NY 11794 2500, USA
    Proc Natl Acad Sci U S A 102:12224-9. 2005
    ..within the repetitive sequence in the transcriptional control region of the serotonin (5-HT) transporter gene (5-HTT, SLC6A4) in modulating amygdala and prefrontal activation to negative emotional stimuli...
  26. ncbi The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation
    Katja Karg
    Department of Human Genetics, University of Wuerzburg, Wuerzburg, Germany
    Arch Gen Psychiatry 68:444-54. 2011
    Two recent meta-analyses assessed the set of studies exploring the interaction between a serotonin transporter promoter polymorphism (5-HTTLPR) and stress in the development of depression and concluded that the evidence did not support ..
  27. ncbi Association of the serotonin transporter promoter region polymorphism with biased attention for negative word stimuli
    Tracy Kwang
    University of Texas at Austin, 78712 0187, USA
    Depress Anxiety 27:746-51. 2010
    ..Biased attention for emotional stimuli reflects vulnerability or resilience to emotional disorders. The current study examines whether the 5-HTTLPR polymorphism is associated with attentional biases for negative word stimuli...
  28. ncbi Serotonin transporter gene polymorphisms and treatment-resistant depression
    Cristian Bonvicini
    Genetic Unit, IRCCS San Giovanni di Dio, Fatebenefratelli, Brescia, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 34:934-9. 2010
    ..Some polymorphisms in the promoter region of the serotonin transporter gene (SLC6A4) are likely to be involved in the pathogenesis/treatment of MDD; however, no data are ..
  29. ncbi Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance
    J Martin
    Mol Psychiatry 12:421-2. 2007
  30. ncbi A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 17:717-23. 2008
    ..Association analyses of common functional variants of the serotonin transporter gene (SLC6A4), a long-standing OCD candidate, have so far been inconsistent...
  31. ncbi 5-HTTLPR biases amygdala activity in response to masked facial expressions in major depression
    Udo Dannlowski
    1 1Department of Psychiatry, University of Munster, Munster, Germany 2 2IZKF Research Group 4, IZKF Münster, University of Munster, Munster, Germany
    Neuropsychopharmacology 33:418-24. 2008
    ..amygdala activity during conscious emotion processing is modulated by a functional polymorphism in the serotonin transporter gene (5-HTTLPR) in healthy subjects...
  32. ncbi Frontal and limbic metabolic differences in subjects selected according to genetic variation of the SLC6A4 gene polymorphism
    A Graff-Guerrero
    Laboratorio de Neurofisiología Integrativa, Instituto Nacional de Psiquiatría Ramón de la Fuente, Mexico City, Mexico
    Neuroimage 25:1197-204. 2005
    Allelic variants in the promoter region of the serotonin transporter (5-HTT) gene have been implicated in several psychiatric disorders and personality traits...
  33. ncbi HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression
    Ian H Gotlib
    Department of Psychology, Stanford University, Stanford, California 94305, USA
    Biol Psychiatry 63:847-51. 2008
    ..indicates that individuals who are homozygous for the short (s) allele in the promoter region of the serotonin transporter gene have higher rates of depression and other psychiatric disorders as a function of exposure to ..
  34. ncbi Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders
    Murray B Stein
    Anxiety and Traumatic Stress Disorders Program, Departments of Psychiatry and Family and Preventive Medicine, University of California San Diego, La Jolla, CA 92093 0855, USA
    Neuropsychopharmacology 33:312-9. 2008
    ..The serotonin transporter gene (SLC6A4) promoter polymorphism (5-HTTLPR) has been associated with depression, but most consistently ..
  35. ncbi Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder
    Xian Zhang Hu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Am J Hum Genet 78:815-26. 2006
    A functional serotonin transporter promoter polymorphism, HTTLPR, alters the risk of disease as well as brain morphometry and function. Here, we show that HTTLPR is functionally triallelic...
  36. ncbi Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism
    Jennifer Pacheco
    Department of Psychology, The University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 29:6229-33. 2009
    Variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been associated with heightened neural activity in limbic and prefrontal regions in response to emotional stimuli...
  37. ncbi Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population
    Xenia Gonda
    Dept of Clinical and Theoretical Mental Health, Kutvolgyi Clinical Centre, Semmelweis University, Kutvolgyi ut 4, 1125, Budapest, Hungary
    Eur Arch Psychiatry Clin Neurosci 259:106-13. 2009
    ..in the background of psychological and psychiatric phenomena is the 5-HTTLPR polymorphism of the serotonin transporter gene which has earlier been found to be associated with neuroticism and neuroticism-related traits and ..
  38. ncbi Serotonin transporter polymorphism and harm avoidance personality in chronic tension-type headache
    Jeong Wook Park
    Department of Neurology, Catholic University of Korea, Seoul, Republic of Korea
    Headache 44:1005-9. 2004
    To investigate the 5-HTT-gene-linked polymorphic region (5-HTTLPR) genotypes and harm avoidance (HA) dimension in chronic tension-type headache (CTH).
  39. ncbi Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: depressive symptomatology among adolescents from low socioeconomic status backgrounds
    Dante Cicchetti
    Institute of Child Development and Department of Psychiatry, University of Minnesota, 51 East River Road, Minneapolis, MN 55455, USA
    Dev Psychopathol 19:1161-80. 2007
    Child maltreatment and polymorphisms of the serotonin transporter (5-HTT) and monoamine oxidase A (MAOA) genes were examined in relation to depressive symptomatology. Adolescents (M age = 16...
  40. ncbi Serotonin transporter genetic variation and the response of the human amygdala
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Science 297:400-3. 2002
    A functional polymorphism in the promoter region of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of neuroticism and psychopathology, especially anxiety traits, but the predictive value of this ..
  41. ncbi Prenatal effects of selective serotonin reuptake inhibitor antidepressants, serotonin transporter promoter genotype (SLC6A4), and maternal mood on child behavior at 3 years of age
    Tim F Oberlander
    Early Human Experience Unit, Developmental Neurosciences and Child Health, and Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    Arch Pediatr Adolesc Med 164:444-51. 2010
    ..selective serotonin reuptake inhibitor (SSRI) antidepressant exposure affects behavior in 3-year-olds of antenatally anxious or depressed mothers and whether risk was moderated by the serotonin transporter promoter (SLC6A4) genotype.
  42. ncbi Candidate genotypes associated with functional dyspepsia
    N van Lelyveld
    Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Neurogastroenterol Motil 20:767-73. 2008
    ..Polymorphisms in genes encoding the serotonin receptor type three A subunit (HTR3A), the serotonin transporter (SERT) and the G-protein beta3 subunit (GNB3) were analysed...
  43. ncbi Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use
    Jonathan Covault
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Biol Psychiatry 61:609-16. 2007
    A common functional polymorphism, 5-HTTLPR, in the serotonin transporter gene has been associated with heavy drinking in college students...
  44. ncbi Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholics
    Maggie Nellissery
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030 2103, USA
    Alcohol Clin Exp Res 27:1402-8. 2003
    ..of these disorders with a functional polymorphism in the promoter region of the gene encoding the serotonin transporter protein (locus SLC6A4) have yielded inconsistent results...
  45. ncbi Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea
    Misuzu Tanaka
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Int J Neuropsychopharmacol 11:261-7. 2008
    ..No significant associations were observed between the other genetic polymorphisms and the incidence of nausea. The -100_-102AAG deletion variant of the 5-HT3B receptor gene may affect paroxetine-induced nausea...
  46. ncbi Association of the long allele of the 5-HTTLPR polymorphism with compulsive craving in alcohol dependence
    Stefan Bleich
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 42:509-12. 2007
    Various studies have reported a role of the serotonin transporter-linked polymorphic region (5-HTTLPR) in alcoholism.
  47. ncbi Combination of the serotonin transporter and norepinephrine transporter gene promoter polymorphisms might influence harm avoidance and novelty seeking in healthy females
    Akihito Suzuki
    Department of Psychiatry, Yamagata University School of Medicine, 2 2 2 Iidanishi, Yamagata 990 9585, Japan
    Neurosci Lett 439:52-5. 2008
    It has been demonstrated that the interaction between serotonin transporter (5HTT) and norepinephrine transporter (NET) functions affects each transporter function and behavior in studies using knockout mice model...
  48. ncbi Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction
    George W Brown
    King s College London, UK
    J Affect Disord 111:1-12. 2008
    Studies of the interaction of the serotonin transporter genotype and environment upon adult depression (G x E) have suggested a role for both childhood maltreatment and stressful life events. This paper deals with two main issues...
  49. ncbi Interaction between gene variants of the serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT) in borderline personality disorder
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University of Mainz, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:487-95. 2009
    ..the low-expression allele of the deletion/insertion (short/long or S/L, respectively) polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR) on the central processing of aversive stimuli...
  50. ncbi Childhood stress, serotonin transporter gene and brain structures in major depression
    Thomas Frodl
    Department of Psychiatry, Institute of Neuroscience, Trinity College, Dublin, Ireland
    Neuropsychopharmacology 35:1383-90. 2010
    ..hippocampal volumes and other brain alterations are associated with the tri-allelic polymorphism of the serotonin transporter and childhood stress in patients with MD and healthy subjects...
  51. ncbi Association of the 5- HTTLPR genotype and unipolar depression: a meta-analysis
    H Clarke
    Department of Experimental Psychology, University of Bristol, UK
    Psychol Med 40:1767-78. 2010
    ..We sought to ascertain the strength of evidence for association between the 5-HTTLPR polymorphism and unipolar depression...
  52. ncbi Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture
    Eric J Lenze
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburg School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 13:428-32. 2005
    The authors examined the serotonin transporter gene-linked polymorphic region (5-HTTLPR) as a predictor of major depressive disorder and depressive symptoms after hip fracture, a common stressful medical event.
  53. ncbi The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 147:543-9. 2008
    b>Serotonin Transporter (5HTT or SLC6A4) mRNA transcription is regulated by both genetic and epigenetic mechanisms...
  54. ncbi Serotonin transporter gene-linked polymorphic region (5-HTTLPR) influences decision making under ambiguity and risk in a large Chinese sample
    Qinghua He
    National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, PR China
    Neuropharmacology 59:518-26. 2010
    ....
  55. ncbi A serotonin transporter gene polymorphism (5-HTTLPR), drinking-to-cope motivation, and negative life events among college students
    Stephen Armeli
    Department of Community Medicine, MC 6325, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 6325, USA
    J Stud Alcohol Drugs 69:814-23. 2008
    This study was performed to examine whether a polymorphism (5-HTTLPR) in the serotonin transporter gene was related to college students' reports of relief drinking (drinking-to-cope motives) and whether it moderated the associations ..
  56. ncbi Association of a functional polymorphism in the serotonin transporter gene with personality traits in females in a Polish population
    Wojciech Ł Dragan
    The Interdisciplinary Center for Behavior Genetic Research, University of Warsaw, Warsaw, Poland
    Neuropsychobiology 54:45-50. 2006
    ..5, p = 0.012). These findings support a role of the 5-HTTLPR polymorphism in the modulation of personality and temperamental traits...
  57. ncbi [Effect to the serotonin transporter gene (5-HTT) on personality dimensions in individuals without psychopathology]
    N Lanzagorta
    Unidad PET Ciclotrón Facultad de Medicina Universidad Nacional Autónoma de México México, D F
    Actas Esp Psiquiatr 34:303-8. 2006
    The aim of the present study was to assess the association between the serotonin transporter gene and the Temperament and Character Inventory (TCI) personality dimensions in subjects without psychopathology.
  58. ncbi Association of 5-HTTLPR serotonin transporter gene polymorphism and Val66Met brain-derived neurotrophic factor gene polymorphism with auditory N100 evoked potential amplitude in patients with endogenous psychoses
    V E Golimbet
    Research Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia
    Bull Exp Biol Med 146:605-8. 2008
    We studied the relationship between genes of serotonin transporter and brain-derived neurotrophic factor and parameters of AEP N100 wave to a non-significant stimulus in patients with endogenous mental diseases...
  59. ncbi Loneliness in adolescence: gene x environment interactions involving the serotonin transporter gene
    Eeske van Roekel
    Behavioural Science Institute, Radboud University Nijmegen, The Netherlands
    J Child Psychol Psychiatry 51:747-54. 2010
    ..Behavioral genetic studies with twin designs have found a significant genetic component for loneliness in children and adults, but no molecular genetic studies have been conducted to reveal the functional polymorphisms involved...
  60. ncbi BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism
    Antonio Terracciano
    National Institute on Aging, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 35:1083-9. 2010
    ..Finally, on the basis of recent reports of an epistatic effect between BDNF and the serotonin transporter, we explored a Val66Met x 5-HTTLPR interaction in a larger SardiNIA sample (n=2333)...
  61. ncbi Anxiety- and novelty seeking-related personality traits and serotonin transporter gene polymorphisms
    Stefan Viktor Vormfelde
    Department of Clinical Pharmacology, Georg August University, University Medical Centre, Robert Koch Str 40, 37075 Gottingen, Germany
    J Psychiatr Res 40:568-76. 2006
    The affection of human personality by the promoter and the intron 2 polymorphism in the serotonin transporter gene (SERT) is inconsistently reported. We aimed to clarify this situation by gender-specific haplotype-phenotype association...
  62. ncbi Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general population
    M Aguilera
    Unitat d Antropologia, Departament Biologia Animal, Facultat de Biologia, Universitat de Barcelona and CIBER de Salud Mental, Instituto de Salud Carlos III, Spain
    Psychol Med 39:1425-32. 2009
    ..b>Serotonin transporter (5-HTT) and brain-derived neurotrophic factor (BDNF) modulate the effect of childhood adversity on adult ..
  63. ncbi Gender moderates the association between 5-HTTLPR and decision-making under ambiguity but not under risk
    Scott F Stoltenberg
    Department of Psychology, Black Hills State University, Spearfish, SD 57799, USA
    Neuropharmacology 58:423-8. 2010
    ..gender moderation of associations between polymorphisms in important serotonin system candidate genes (serotonin transporter [SLC6A4] and tryptophan hydroxylase-2 [TPH2]) and performance on a decision-making task (Iowa Gambling ..
  64. ncbi Effect of chronic analgesic exposure on the central serotonin system: a possible mechanism of analgesic abuse headache
    A Srikiatkhachorn
    Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Headache 40:343-50. 2000
    ..Characteristics of the specific binding of the 5-HT2A serotonin receptor and the serotonin transporter were studied using a radioligand binding technique...
  65. ncbi Long-term neuronal damage and recovery after a single dose of MDMA: expression and distribution of serotonin transporter in the rat brain
    Eszter Kirilly
    Semmelweis University, Department of Pharmacodynamics, Budapest, Hungary
    Neuropsychopharmacol Hung 12:413-23. 2010
    ..b>Serotonin transporter (5-HTT) mRNA in the raphe nuclei also has not been examined...
  66. ncbi Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1264, USA
    Int J Neuropsychopharmacol 12:1055-65. 2009
    ..We recently reported a genetic mouse model for the serotonin syndrome, as serotonin transporter (SERT)-deficient mice have exaggerated serotonin syndrome behavioural responses to the MAOI ..
  67. ncbi Does pretreatment testing for serotonin transporter polymorphisms lead to earlier effects of drug treatment in patients with major depression? A decision-analytic model
    Kim M Smits
    Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
    Clin Ther 29:691-702. 2007
    ..Therefore, a test to identify potential nonresponders could be useful in the treatment of depression. Serotonin transporter gene (SLC6A4) variations have been reported to account for differences in the way individuals respond to ..
  68. ncbi Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Brain 131:120-31. 2008
    ..in PD is derived in large part from findings of decreased binding of different radioligands to the serotonin transporter (SERT), one 'marker' of serotonin neurons...
  69. ncbi Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropharmacology 53:643-56. 2007
    ..We previously reported that mice with a targeted disruption of the serotonin transporter (SERT) display some of these behaviors spontaneously, in the absence of drug...
  70. ncbi Lack of 5-HT(1B) receptor and of serotonin transporter have different effects on the segregation of retinal axons in the lateral geniculate nucleus compared to the superior colliculus
    A L Upton
    INSERM U106, Hopital de la Pitie Salpetriere, Paris, France
    Neuroscience 111:597-610. 2002
    ..We analysed the retinal projections of 5-HT(1B) knockout (n=15), serotonin transporter knockout (n=14), serotonin transporter/5-HT(1B) double knockout (n=4) and monoamine oxidase A/5-HT(1B) ..
  71. ncbi Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice
    Yvonne Dempsie
    Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    Circulation 117:2928-37. 2008
    ..Here, we used novel transgenic mice lacking peripheral serotonin (deficient in tryptophan hydroxylase-1; Tph1(-/-) mice) or overexpressing the gene for the human serotonin transporter (SERT; SERT(+) mice) to investigate this further.
  72. ncbi Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice
    Meredith A Fox
    Laboratory of Clinical Science LCS, National Institute of Mental Health NIMH, National Institutes of Health NIH, 10 Center Drive, Building 10 3D41, MSC 1264, Bethesda, MD 20892 1264, USA
    Psychopharmacology (Berl) 201:203-18. 2008
    b>Serotonin transporter (SERT) knockout (-/-) mice have an altered phenotype in adulthood, including high baseline anxiety and depressive-like behaviors, associated with increased baseline extracellular serotonin levels throughout life.
  73. ncbi Modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study
    G Gobbi
    Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, Canada
    J Pharmacol Exp Ther 296:987-95. 2001
    The serotonin transporter (5-HTT) plays a key role in the regulation of serotonin (5-hydroxytryptamine, 5-HT) transmission in the pathophysiology and therapeutics of several psychiatric disorders...
  74. ncbi Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin
    S Eddahibi
    Departement de Physiologie, INSERM U492, Creteil, France
    Circ Res 84:329-36. 1999
    ..This effect was dependent on the 5-HT transporter (5-HTT), since it was prevented by the 5-HTT inhibitors fluoxetine (10(-6) mol/L) and paroxetine (10(-7) mol/L), but it ..
  75. ncbi Comparison of seven different heterologous protein expression systems for the production of the serotonin transporter
    Christopher G Tate
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Biochim Biophys Acta 1610:141-53. 2003
    The rat serotonin transporter (rSERT) is an N-glycosylated integral membrane protein with 12 transmembrane regions; the N-glycans improve the ability of the SERT polypeptide chain to fold into a functional transporter, but they are not ..
  76. ncbi Serotonin transporter deficiency in rats contributes to impaired object memory
    J D A Olivier
    Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Molecular Neurobiology and Psychoneuropharmacology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Genes Brain Behav 8:829-34. 2009
    Serotonin is well known for its role in affection, but less known for its role in cognition. The serotonin transporter (SERT) has an essential role in serotonergic neurotransmission as it determines the magnitude and duration of the ..
  77. ncbi Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
    Hristina Jovanovic
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Neuroimage 39:1408-19. 2008
    ..in the serotonin system, serotonin(1A) (5-HT(1A)) receptor is implicated in depression, and anxiety and serotonin transporter (5-HTT) is a target for selective serotonin reuptake inhibitors, psychotropic drugs used in the treatment ..
  78. ncbi Seasonal variation in human brain serotonin transporter binding
    Nicole Praschak-Rieder
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, 250 College St, Toronto, ON M5T 1R8, Canada
    Arch Gen Psychiatry 65:1072-8. 2008
    ..The serotonin transporter is a key element in regulating intensity and spread of the serotonin signal.
  79. ncbi Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Am J Psychiatry 155:207-13. 1998
    Earlier platelet and postmortem brain studies have found alterations in serotonin transporter function in ethanol-abusing human subjects...
  80. ncbi cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake
    Jennifer A Steiner
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Brain 2:26. 2009
    The Na(+)/Cl(-)-dependent serotonin (5-hydroxytryptamine, 5-HT) transporter (SERT) is a critical element in neuronal 5-HT signaling, being responsible for the efficient elimination of 5-HT after release...
  81. ncbi Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression
    Tiffany A Mathews
    Department of Chemistry, The Pennsylvania State University, 104 Chemistry Building, University Park, PA 16802 6300, USA
    J Neurosci Methods 140:169-81. 2004
    ..Many therapeutic and illicit drugs that modulate these functions act at the serotonin transporter (SERT), thus a mouse model with reduced transporter expression was created to further investigate the ..
  82. ncbi Eating disorders, serotonin transporter polymorphisms and potential treatment response
    Philip Gorwood
    Service de Psychiatrie, Hôpital Louis Mourier AP HP, 178 rue des Renouillers, 92700 Colombes, France
    Am J Pharmacogenomics 4:9-17. 2004
    ..The serotonin transporter (5-HTT), encoded by the SLC6A4 gene, may also have an important role in eating disorders, as its ..
  83. ncbi Metabolic and reproductive consequences of the serotonin transporter promoter polymorphism (5-HTTLPR) in adult female rhesus monkeys (Macaca mulatta)
    J B Hoffman
    Division of Psychobiology, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Endocrine 31:202-11. 2007
    The serotonin (5HT) reuptake transporter (SERT) plays a key role in 5HT homeostasis by recycling 5HT into the presynaptic neurons...
  84. ncbi Genetics of the serotonergic system in suicidal behavior
    Victoria Arango
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    J Psychiatr Res 37:375-86. 2003
    ..polymorphisms in the serotonin biosynthetic enzyme tryptophan hydroxylase (TPH; A779C substitution), the serotonin transporter (5-HTT, 5-HTTLPR allele), the 5-HT(1B) receptor (G861C, C129T substitution) and the 5-HT(2A) receptor (..
  85. ncbi Sex hormone-dependent desensitization of 5-HT1A autoreceptors in knockout mice deficient in the 5-HT transporter
    Saoussen Bouali
    INSERM U288, NeuroPsychoPharmacologie Moléculaire Cellulaire et Fonctionalle, France
    Eur J Neurosci 18:2203-12. 2003
    The serotonin transporter (5-HTT) is the target of most antidepressant drugs, whose therapeutic action is related to their facilitatory influence on 5-HT neurotransmission...
  86. ncbi Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats
    Jocelien D A Olivier
    Department Cognitive Neuroscience Psychoneuropharmacology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Pharmacol 590:190-7. 2008
    Disturbances in the serotonergic system are implicated in many central nervous system disorders. The serotonin transporter (SERT) regulates the serotonin homeostasis in the synapse...
  87. ncbi Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities
    C Sanchez
    Research Laboratories, H Lundbeck A S, Ottiliavej 9, 2500 Copenhagen, Denmark
    Psychopharmacology (Berl) 167:353-62. 2003
    ..The pharmacological profile of escitalopram, the S-(+)-enantiomer of citalopram, was studied and compared with citalopram and the R-(-)-enantiomer, R-citalopram...
  88. ncbi Expression of serotonin transporter protein in developing rat brain
    F C Zhou
    Department of Anatomy, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res Dev Brain Res 119:33-45. 2000
    b>Serotonin transporter (5-HTT), a transmembrane protein, has been shown in adult brain to be distributed not only on synaptic terminals but to a great extent on axons as well...
  89. ncbi Serotonin regulates osteoclast differentiation through its transporter
    Ricardo Battaglino
    Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts 02115, USA
    J Bone Miner Res 19:1420-31. 2004
    5-HTT mediates antidepressant-sensitive clearance of 5-HT after its release into neural synapses. We found increased expression of 5-HTT in RANKL-induced osteoclast-like cells...
  90. ncbi Continuous fluoxetine administration prevents recurrence of pulmonary arterial hypertension and prolongs survival in rats
    Shao Ping Zhu
    Department of Cardiothoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China
    Clin Exp Pharmacol Physiol 36:e1-5. 2009
    1. The serotonin transporter (SERT) is strongly implicated in the pathogenesis of pulmonary arterial hypertension (PAH) in patients and animal models...
  91. ncbi Transporter-mediated release: a superfusion study on human embryonic kidney cells stably expressing the human serotonin transporter
    P Scholze
    Department of Pharmacology, University of Vienna, Austria
    J Pharmacol Exp Ther 293:870-8. 2000
    HEK 293 cells stably expressing the human serotonin transporter (hSERT) were grown on coverslips, preincubated with [(3)H]5-hydroxytryptamine (5-HT), and superfused. Substrates of the hSERT [e.g...
  92. ncbi Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines
    Tao Xie
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:2639-51. 2006
    We studied in vivo expression of the serotonin transporter (SERT) protein after 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine (PCA), or fenfluramine (FEN) treatments, and compared the effects of substituted amphetamines ..
  93. ncbi Substituted amphetamines that produce long-term serotonin depletion in rat brain ("neurotoxicity") do not decrease serotonin transporter protein expression
    Richard B Rothman
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 1025:151-61. 2004
    ..of high-dose D-fenfluramine (D-FEN) or parachloroamphetamine (PCA) produces long-lasting decreases in serotonin transporter (SERT) binding and tissue levels of serotonin (5-HT) in rat forebrain...
  94. ncbi Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease
    Jeremy M Van Raamsdonk
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Hum Mol Genet 14:1379-92. 2005
    ..disease (HD) is an adult-onset neurodegenerative disease caused by a toxic gain of function in the huntingtin (htt) protein. The contribution of wild-type htt function to the pathogenesis of HD is currently uncertain...
  95. ncbi High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography
    Tetsuya Suhara
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Arch Gen Psychiatry 60:386-91. 2003
    Serotonin transporters (5-HTT) are regarded as one of the major therapeutic targets of antidepressants...
  96. ncbi Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression
    Mahmoud A Pouladi
    Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, and Child and Family Research Institute, Vancouver, BC, Canada V5Z 4H4
    Hum Mol Genet 19:1528-38. 2010
    Levels of full-length huntingtin (FL htt) influence organ and body weight, independent of polyglutamine length...
  97. ncbi Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacology
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    World J Biol Psychiatry 3:133-46. 2002
    ..Genotyping depressed patients for the serotonin transporter promoter gene region (5-HTTLPR) did not provide evidence for in vivo functional regulation of 5-HTT ..
  98. ncbi Upregulation of serotonin transporter by alcohol in human dendritic cells: possible implication in neuroimmune deregulation
    Dakshayani Kadiyala Babu
    Department of Immunology, College of Medicine, Institute of Neuroimmune Pharmacology, Florida International University, Miami, Florida 33199, USA
    Alcohol Clin Exp Res 33:1731-8. 2009
    ..5-HT is selectively transported into neurons through the serotonin transporter (SERT), which is a member of the sodium- and chloride-dependent neurotransmitter transporter (SLC6) family...
  99. ncbi (+)-Norfenfluramine-induced arterial contraction is not dependent on endogenous 5-hydroxytryptamine or 5-hydroxytryptamine transporter
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, 48824 1317, USA
    J Pharmacol Exp Ther 314:953-60. 2005
    ..Norfenfluramine was reported as a 5-hydroxytryptamine transporter (5-HTT) substrate and 5-HT releaser...
  100. ncbi Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336, Munchen, Germany
    Psychiatry Res 96:51-61. 2000
    ..and impulsivity in alcohol-dependent and age-matched control subjects in relation to a 5'-promoter region serotonin transporter (5-HTT) polymorphism (5-HTTLPR)...

Research Grants73

  1. 5-HT transporter function: Interaction of antidepressants and hormones
    Alan Frazer; Fiscal Year: 2010
    ..SSRIs) to alter the function of what is widely considered their initial cellular target in brain - the serotonin transporter (SERT)...
  2. DORSAL RAPHE NUCLEUS SEROTONIN NEURONS IN ALCOHOLISM
    Mark Underwood; Fiscal Year: 2009
    ..DRN) of increased tryptophan hydroxylase (TPH) serotonin-synthesizing enzyme, a decrease in the amount of serotonin transporter and 5-HT1A inhibitory autoreceptor binding and in the prefrontal cortex (PFC) of reduced 5-HT2A receptor ..
  3. DORSAL RAPHE NUCLEUS SEROTONIN NEURONS IN ALCOHOLISM
    Mark D Underwood; Fiscal Year: 2010
    ..DRN) of increased tryptophan hydroxylase (TPH) serotonin-synthesizing enzyme, a decrease in the amount of serotonin transporter and 5-HT1A inhibitory autoreceptor binding and in the prefrontal cortex (PFC) of reduced 5-HT2A receptor ..
  4. PET IMAGING OF SEROTONIN TRANSPORTERS IN THE BRAIN
    Hank F Kung; Fiscal Year: 2010
    ..The serotonin transporter imaging agents to be tested in this project are critically important for studying binding of ..
  5. Communication between platelet SERT and plasma 5HT
    Fusun Kilic; Fiscal Year: 2009
    The serotonin transporter (SERT) on the platelet surface is the major mechanism for the uptake of plasma serotonin (5-hydroxytryptamine; 5HT), which subsequently is stored in platelet dense granules...
  6. Communication between platelet SERT and plasma 5HT
    Fusun Kilic; Fiscal Year: 2010
    The serotonin transporter (SERT) on the platelet surface is the major mechanism for the uptake of plasma serotonin (5-hydroxytryptamine;5HT), which subsequently is stored in platelet dense granules...
  7. Communication between platelet SERT and plasma 5HT
    Fusun Kilic; Fiscal Year: 2009
    The serotonin transporter (SERT) on the platelet surface is the major mechanism for the uptake of plasma serotonin (5-hydroxytryptamine; 5HT), which subsequently is stored in platelet dense granules...
  8. The Norepinephrine Transporter as a Novel Target for a Bone Anabolic Treatment
    Florent Elefteriou; Fiscal Year: 2009
    ..Anti-depressants, depending on their selectivity, target the serotonin transporter (SERT) or the norepinephrine transporter (NET) in neurons...
  9. The Norepinephrine Transporter as a Novel Target for a Bone Anabolic Treatment
    Florent Elefteriou; Fiscal Year: 2010
    ..Anti-depressants, depending on their selectivity, target the serotonin transporter (SERT) or the norepinephrine transporter (NET) in neurons...
  10. Cocaine Use and Monoamine Function
    Leonard L Howell; Fiscal Year: 2010
    ..Specifically, selective serotonin transporter (SERT) inhibitors can effectively attenuate cocaine self-administration and cocaine-induced increases in ..
  11. 5-HT Reuptake in SERT Knockout Mice by Voltammetry
    ANNE ANDREWS; Fiscal Year: 2004
    ..methods for the determination of real-time serotonin reuptake and release in brain tissue derived from serotonin transporter knockout mice...
  12. Serotonin and the Modulation of Brain Development
    Jay A Gingrich; Fiscal Year: 2010
    The serotonin transporter (SERT) is a critical regulator of emotional function that acts both during brain development as a growth modulator and as a neurotransmitter in the more mature brain...
  13. Serotonin and the Modulation of Brain Development
    Jay A Gingrich; Fiscal Year: 2011
    The serotonin transporter (SERT) is a critical regulator of emotional function that acts both during brain development as a growth modulator and as a neurotransmitter in the more mature brain...
  14. Mechanisms Regulating Serotonin Clearance In Vivo: Studies Using KO Mice
    Lynette Daws; Fiscal Year: 2007
    The serotonin transporter (5-HTT) regulates serotonergic neurotransmission by high affinity uptake of released serotonin. It is a key site of action for many psychotherapeutic and addictive drugs...
  15. Mechanisms Regulating Serotonin Clearance In Vivo: Studies Using KO Mice
    Lynette C Daws; Fiscal Year: 2010
    The serotonin transporter (5-HTT) regulates serotonergic neurotransmission by high affinity uptake of released serotonin. It is a key site of action for many psychotherapeutic and addictive drugs...
  16. Monoamine Transporter Structure-Function Studies
    CHRISTOPHER SURRATT; Fiscal Year: 2007
    ..The serotonin transporter protein (SERT) also plays a key role in the mood-altering effects of these drugs, especially in the case ..
  17. Development and Applications of Novel SERT PET Ligands
    Mark Goodman; Fiscal Year: 2006
    Considerable evidence accrued over the last two decades have convincingly implicated decreased serotonin transporter (SERT) binding in the pathophysiology of major depression and suicide...
  18. CRCNS: Computational and experimental study of dopamine and serotonin transporter
    JEFFRY MADURA; Fiscal Year: 2009
    ..proposes structure, function, and dynamic studies on the plasma membrane dopamine (DAT) and serotonin transporters (SERT)...
  19. CRCNS: Computational and experimental study of dopamine and serotonin transporter
    Jeffry D Madura; Fiscal Year: 2010
    ..proposes structure, function, and dynamic studies on the plasma membrane dopamine (DAT) and serotonin transporters (SERT)...
  20. Depression and functional outcomes in COPD: Impact of genetics and inflammation
    HUONG Q contact NGUYEN; Fiscal Year: 2010
    ..serotonin which is involved in the pathophysiology of affective disorders is regulated by the serotonin transporter (SERT) that controls reuptake of serotonin at brain synapses...
  21. The PPAR-delta pathway in neural function and Hungtington's disease neuropatholog
    Albert R La Spada; Fiscal Year: 2010
    Recent published studies by our laboratory and others have shown that mutant huntingtin (htt)-mediated transcription dysregulation of PGC-11 disrupts expression of genes necessary for normal mitochondrial function and energy metabolism ..
  22. Role of Huntington's Disease Protein in Post-Transcriptional Gene Silencing
    Naoko Tanese; Fiscal Year: 2010
    ..disorder caused by an expanded poly-glutamine (polyQ) tract within the amino-terminus of the huntingtin (Htt) protein, whose cellular function remains controversial...
  23. 5HTT and 5-HT2A Receptors in Impulsive Aggression and Effects of Fluoxetine
    Larry J Siever; Fiscal Year: 2010
    ..MDL100907 binding to the 5-HT2A receptor in orbital frontal cortex and to characterize [11C] DASB binding to the 5HTT in the anterior cingulate cortex in 60 IED-R patients with personality disorders and 20 matched healthy volunteer ..
  24. Use of Chronoamperometry to Measure Extracellular 5 HT
    Alan Frazer; Fiscal Year: 2005
    ..study the functional consequences and mechanisms underlying antidepressant-induced down-regulation of the serotonin transporter (SERT) and norepinephrine transporter (NET)...
  25. Transgenic Mouse Model to Address Heterogeneity in Autism Spectrum Disorders
    RANDY DEAN BLAKELY; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Rare, functional gene variants that lead to hyperfunction of the serotonin transporter (SERT) have been associated with a specific subset of autism spectrum traits, rigid-compulsive behaviors ..
  26. The Role of Microglia and the Kynurenine Pathway in Huntington's Disease
    Paul Muchowski; Fiscal Year: 2009
    ..is a fatal neurodegenerative disorder caused by an expanded polyglutamine (polyQ) tract in the protein huntingtin (htt)...
  27. The Role of Microglia and the Kynurenine Pathway in Huntington's Disease
    Paul Muchowski; Fiscal Year: 2009
    ..is a fatal neurodegenerative disorder caused by an expanded polyglutamine (polyQ) tract in the protein huntingtin (htt)...
  28. The Role of Microglia and the Kynurenine Pathway in Huntington's Disease
    Paul J Muchowski; Fiscal Year: 2010
    ..is a fatal neurodegenerative disorder caused by an expanded polyglutamine (polyQ) tract in the protein huntingtin (htt)...
  29. Transgenic Mouse Model to Address Heterogeneity in Autism Spectrum Disorders
    Randy Blakely; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Rare, functional gene variants that lead to hyperfunction of the serotonin transporter (SERT) have been associated with a specific subset of autism spectrum traits, rigid-compulsive behaviors ..
  30. Genes, Brain, and Behavior in Human Aggression
    Nelly Alia Klein; Fiscal Year: 2010
    ..Other monoamine regulators, such as catechol-O-methyltransferase (COMT) and the serotonin transporter (5-HTT), together with MAO A, are also implicated as neurochemical markers in the study and treatment of ..
  31. Geriatric Depression: PET Studies of Pathophysiology and Treatment Response
    Gwenn S Smith; Fiscal Year: 2010
    ..in PET instrumentation and radiotracer chemistry, with postmortem and neuroimaging data, to investigate serotonin transporter (SERT) occupancy by a selective serotonin reuptake inhibitor (SSRI, citalopram) and beta-amyloid ..
  32. Evolving membrane proteins for high-level expression in modified mammalian cells
    Michael J Betenbaugh; Fiscal Year: 2010
    ..For example, the four biomedically important MMPs: serotonin transporter (SERT), neurotensin receptor (NTR), mesenchymal-epithelial transition factor (MET) receptor, and voltage-..
  33. Mechanism of Fast Axonal Transport Inhibition by PolyQ-Expanded Huntingtin
    Sarah Pollema; Fiscal Year: 2007
    ..gene disease displays dominant inheritance, and is thought to involve a toxic gain of function in the Huntingtin (Htt) protein...
  34. Imaging 5-HT2A Receptors in Patients with Impulsive Aggression and Controls with
    Larry Siever; Fiscal Year: 2005
    ..DESCRIPTION: (provided by applicant) The proposed studies are designed to evaluate 5-hydroxytryptophan transporter (5-HTT) binding of [S11C] McN5652 in midbrain and 5-HT2a receptor binding of [S11C] MDLIOO9O7 in orbital frontal cortex in ..