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| RUVBL1SummaryGene Symbol: RUVBL1 Description: RuvB-like 1 (E. coli) Alias: ECP54, INO80H, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49, TIP49A, 49 kDa TATA box-binding protein-interacting protein, 49 kDa TBP-interacting protein, 54 kDa erythrocyte cytosolic protein, ECP-54, INO80 complex subunit H, NMP 238, RuvB (E coli homolog)-like 1, TAP54-alpha, TATA binding protein interacting protein 49 kDa, TIP60-associated protein 54-alpha, nuclear matrix protein 238, pontin 52, ruvB-like 1 Species: human Top Publications
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Publications
Evolutionarily conserved transcriptional co-expression guiding embryonic stem cell differentiationYu Sun
Bioinformatics Unit, Research Resources Branch, National Institute on Aging, NIH, Baltimore, MD, USA
PLoS ONE 3:e3406. 2008..Cross-species examination of transcriptional co-expression allows elucidation of fundamental and species-specific mechanisms regulating ESC self-renewal or differentiation...- The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genesJose Sierra
Regulatory Biology Laboratory, The Salk Insitute for Biological Studies, La Jolla, California 92037, USA
Genes Dev 20:586-600. 2006..We conclude that, in addition to regulating the stability of beta-cat, APC facilitates CtBP-mediated repression of Wnt target genes in normal, but not in colorectal cancer cells... - An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-MycM A Wood
Department of Molecular Biology, Princeton University, New Jersey 08544, USA
Mol Cell 5:321-30. 2000..Two of these proteins were identified as TIP49 and a novel related protein called TIP48, both of which are highly conserved in evolution and contain ATPase/.. - Dodecameric structure and ATPase activity of the human TIP48/TIP49 complexTeena Puri
Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, UK
J Mol Biol 366:179-92. 2007TIP48 and TIP49 are two related and highly conserved eukaryotic AAA(+) proteins with an essential biological function and a critical role in major pathways that are closely linked to cancer... - Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activityA Bauer
Max Planck Institute of Immunobiology, Department of Molecular Embryology, Stubeweg 51, D 79108 Freiburg, Germany
EMBO J 19:6121-30. 2000..We recently identified Pontin52 as a nuclear protein interacting with beta-catenin and the TATA-box binding protein (TBP), suggesting its .. - Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosisT Ikura
Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 102:463-73. 2000..These results indicate that the histone acetylase TIP60-containing complex plays a role in DNA repair and apoptosis... - TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49aM Kanemaki
Department of Biology, Faculty of Science, Chiba University, CREST Japan Science and Technology Corp, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
J Biol Chem 274:22437-44. 1999We previously reported that TIP49a is a novel mammalian DNA helicase showing structural similarity with the bacterial recombination factor RuvB... - Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding proteinA Bauer
Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
Proc Natl Acad Sci U S A 95:14787-92. 1998..Here we report the identification of an interaction partner of beta-catenin, a nuclear protein designated Pontin52. Pontin52 binds beta-catenin in the region of Armadillo repeats 2-5 and, more importantly, also binds the TATA .. - Molecular cloning of a rat 49-kDa TBP-interacting protein (TIP49) that is highly homologous to the bacterial RuvBM Kanemaki
Department of Biology, Faculty of Science, Chiba University, Inage Ku, Japan
Biochem Biophys Res Commun 235:64-8. 1997..for affinity-purification of TBP-bound proteins, we isolated a 49-kD protein termed TBP-interacting protein 49 (TIP49) from rat liver nuclear extracts... - Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexesJung Hwa Kim
Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 742, South Korea
Nature 434:921-6. 2005.... - Yeast Rvb1 and Rvb2 are ATP-dependent DNA helicases that form a heterohexameric complexAnna Gribun
Department of Biochemistry, University of Toronto, Toronto, ON, Canada
J Mol Biol 376:1320-33. 2008b>Rvb1 and Rvb2 are highly conserved proteins present in archaea and eukaryotes. These proteins are members of a large superfamily of ATPases associated with diverse cellular activities--the AAA(+) superfamily... - In restless legs syndrome, during changes in vigilance, the forced EEG shifts from alpha activity to delta or high alpha may lead to the altered states of dopamine receptor function and the symptomsSevket Akpinar
Department of Neurology, Gulhane Military Medical Academy, Medical Faculty Etlik, Ankara, Turkey
Med Hypotheses 69:273-81. 2007..B. Activation state is an increase in symptoms. Sensory intralaminar and motor pontin nuclei neurons are in fact excitatory but are disinhibited in RLS... - Molecular cloning of mouse p47, a second group mammalian RuvB DNA helicase-like protein: homology with those from human and Saccharomyces cerevisiaeT Gohshi
Department of Biochemistry, Faculty of Science, Okayama University Dental School, Okayama, 700 8525, Japan
J Biochem 125:939-46. 1999..They also show homology with the putative mammalian helicases p50/TIP49 and RUVBL1. Comparison of the amino acid sequences of p47 group proteins and those of p50/TIP49 group proteins revealed the .. - Mapping genomic targets of DNA helicases by chromatin immunoprecipitation in Saccharomyces cerevisiaeJennifer Cobb
Department of Biochemistry and Molecular Biology, Southern Alberta Cancer Research Institute, University of Calgary, Calgary, AB, Canada
Methods Mol Biol 587:113-26. 2010..complexes including the minichromosome maintenance (Mcm) proteins 2-7, the RecQ helicase Sgs1 as well as the Rvb1 and Rvb2 helicase-containing INO80 and SWR1 chromatin remodeling complexes... - [Camillo Golgi and the contribution of the Italian scientists to the development of the malariology in the last quarter of the nineteenth century]Eugenia Tognotti
Dipartimento di Storia, Universita di Sassari, I
Med Secoli 19:101-17. 2007..Bacillus malariae, isolated by Klebs and Tommasi Crudeli before Laveran's discovery in the ground and water of the Pontin Marshes south of Rome, his studies determined the definitive disappearance from the scene of this bacterium; and .. - Profilin 1 obtained by proteomic analysis in all-trans retinoic acid-treated hepatocarcinoma cell lines is involved in inhibition of cell proliferation and migrationNan Wu
Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, P R China
Proteomics 6:6095-106. 2006..Furthermore, RNAi-based PFN1 knockdown could rescue the inhibitory effect of ATRA on cell proliferation and migration. In conclusion, ATRA inhibited cell proliferation and migration through up-regulation of PFN1... - Mapping the integrin-linked kinase interactome using SILACIveta Dobreva
Department of Cancer Genetics, British Columbia Cancer Research Centre, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada
J Proteome Res 7:1740-9. 2008.... - A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprintingD Frank
Institute for Cancer Genetics and Department of Pathology, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, New York 10032, USA
Mamm Genome 10:1150-9. 1999..Ipl is similar to TDAG51, a gene that is involved in FAS/CD95 expression. Here we describe another gene, Tih1 (TDAG/Ipl homologue 1), with equivalent sequence similarity to Ipl... - Human TIP49b/RUVBL2 gene: genomic structure, expression pattern, physical link to the human CGB/LHB gene cluster on chromosome 19q13.3B Parfait
Laboratoire de Genetique Moleculaire, UPRES JE 2195, Faculté des Sciences Pharmaceutiques et Biologiques de Paris, 4, avenue de l Observatoire, 75006, Paris, France
Ann Genet 43:69-74. 2000..The TIP49b/RUVBL2 open reading frame encodes a protein of 463 amino acids, showing 43% identity with the RUVBL1 protein. The TIP49b/RUVBL2 gene is physically linked to the human CGB/LHB gene cluster on chromosome 19q13.3... - Reptin and pontin antagonistically regulate heart growth in zebrafish embryosWolfgang Rottbauer
Cardiovascular Research Center, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
Cell 111:661-72. 2002..With regard to heart growth, beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways... - Functional and comparative characterization of Saccharomyces cerevisiae RVB1 and RVB2 genes with bacterial Ruv homologuesSlobodanka Radovic
Yeast Molecular Genetics Group, ICGEB, Area Science Park W, Trieste, Italy
FEMS Yeast Res 7:527-39. 2007Expression of yeast RuvB-like gene analogues of bacterial RuvB is self-regulated, as episomal overexpression of RVB1 and RVB2 decreases the expression of their chromosomal copies by 85%... - MYC recruits the TIP60 histone acetyltransferase complex to chromatinScott R Frank
DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
EMBO Rep 4:575-80. 2003..TIP60 and recruits it to chromatin in vivo with four other components of the TIP60 complex: TRRAP, p400, TIP48 and TIP49. Overexpression of enzymatically inactive TIP60 delays the MYC-induced acetylation of histone H4, and also reduces .. - Expansion of chromosome territories with chromatin decompaction in BAF53-depleted interphase cellsKiwon Lee
Department of Bioscience and Biotechnology, Hankuk University of Foreign Studies, Yongin 449 791, Korea
Mol Biol Cell 18:4013-23. 2007..The histone hyperacetylation and down-regulation of BRG-1, mBrm, and Tip49, the catalytic components of the SWI/SNF complex and the TIP60 complex, respectively, did not expand chromosome .. - Oligomeric assembly and interactions within the human RuvB-like RuvBL1 and RuvBL2 complexesAndrew Niewiarowski
Department of Structural and Molecular Biology, Darwin Building, University College London, Gower Street, London WC1E 6BT, UK
Biochem J 429:113-25. 2010The two closely related eukaryotic AAA+ proteins (ATPases associated with various cellular activities), RuvBL1 (RuvB-like 1) and RuvBL2, are essential components of large multi-protein complexes involved in diverse cellular processes... - Increased pontin expression in human colorectal cancer tissueJohannes C Lauscher
Department of General, Vascular and Thoracic Surgery, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
Hum Pathol 38:978-85. 2007..b>Pontin, a member of the AAA(+) superfamily, has previously been shown to interact with beta-catenin and to enhance TCF/.. - A rat RuvB-like protein, TIP49a, is a germ cell-enriched novel DNA helicaseY Makino
Department of Biology, Faculty of Science, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
J Biol Chem 274:15329-35. 1999We have isolated a novel nuclear protein with a molecular mass of 49 kDa (TIP49a) from rat liver. The rat TIP49a showed structural resemblance to several bacterial RuvBs and also displayed Walker A and B motifs... - Hydrogen release from titanium hydride in foaming of orthopedic NiTi scaffoldsShuilin Wu
Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062, People s Republic of China
Acta Biomater 7:1387-97. 2011..Hydrogen is released in two transitions: TiH1.924?TiH1.5/TiH1.7 between 300 °C and 400 °C and TiH1.5/TiH1.7??-Ti between 400 °C and 600 °C... - Cooperative action of TIP48 and TIP49 in H2A.Z exchange catalyzed by acetylation of nucleosomal H2AJongkyu Choi
Department of Biochemistry and Molecular Biology, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
Nucleic Acids Res 37:5993-6007. 2009..Z exchange reaction. Among factors present in the small complex, we determined that TIP48 and TIP49 play a major role in catalyzing H2A acetylation-induced H2A.Z exchange via their ATPase activities... - A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assemblyKenneth Scott McKeegan
Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Mol Cell Biol 27:6782-93. 2007..four novel human biogenesis factors (BCD1, NOP17, NUFIP, and TAF9) which, along with the ATPases TIP48 and TIP49, are likely to be involved in the formation of the pre-snoRNP... - When ATPases pontin and reptin met telomeraseSung Hee Baek
Department of Biological Sciences, Research Center for Functional Cellulomics, Seoul National University, Seoul 151 742, South Korea
Dev Cell 14:459-61. 2008b>Pontin and reptin are conserved AAA+ ATPases identified in chromatin-remodeling complexes. In a recent issue of Cell, Venteicher et al... - URI-1 is required for DNA stability in C. elegansChristine T Parusel
Eidgenoessische Technische Hochschule Zuerich, Institute of Cell Biology, CH 8093 Zuerich, Switzerland
Development 133:621-9. 2006..transcriptional machinery, including RPB5, a shared subunit of all three RNA polymerases, the ATPases TIP48 and TIP49, which are present in various chromatin remodeling complexes, and human PAF1 and parafibromin, which are .. - Association of central pontin myelinolysis and extra-pontin myelinolysis in diabetic patientAli Akyol
Department of Neurology, Medical Faculty, Adnan Menderes University, Turkey
Neuro Endocrinol Lett 28:252-4. 2007Central pontin myelinolysis and extra-pontin myelinolysis (CPM/EPM) implies the clinical picture after rapid recovery of hyponatremia or hyponatremia alone. SPM/EPM picture can occur without hyponatremia... - Microarray analysis of gene-expression profiles in diffuse large B-cell lymphoma: identification of genes related to disease progressionMieko Nishiu
Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
Jpn J Cancer Res 93:894-901. 2002..Increased expression of MPHOSPH1, RUVBL1, CHN2, PSA and CDC10 genes, and reduced expression of COL1A2, COL4A1, FBLN5, CLECSF6, MIC2, CAV1 and S100A10 genes .. - The multifaceted proteins Reptin and Pontin as major players in cancerAude Grigoletto
INSERM, U889, F 33076 Bordeaux, France Université de Bordeaux, F 33076 Bordeaux, France
Biochim Biophys Acta 1815:147-57. 2011Reptin and Pontin belong to the family of AAA+ ATPases (ATPases Associated with various cellular Activities). Several studies have reported their overexpression in cancer, including hepatocellular carcinoma and colorectal cancer... - Placental overgrowth in mice lacking the imprinted gene IplDale Frank
Institute for Cancer Genetics, Department of Pathology, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 99:7490-5. 2002..deletions of this gene (Ipl(neo) and Ipl(loxP)) and another line deleted for the similar but nonimprinted gene Tih1. All three lines were viable... - Evaluation of clustering algorithms for protein complex and protein interaction network assemblyMihaela E Sardiu
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
J Proteome Res 8:2944-52. 2009..but highly complex human protein interaction network data set centered around the conserved AAA+ ATPases Tip49a and Tip49b... - Chromosomal aberrations and gene expression profiles in non-small cell lung cancerE Dehan
Sackler School of Medicine, Tel Aviv University, Israel
Lung Cancer 56:175-84. 2007..We verified the changes in expressions of MCM2, MCM6, RUVBL1, MMP1, MMP12 by real-time quantitative PCR... - Human embryonic and mesenchymal stem cells express different nuclear proteomesAmritha Jaishankar
Department of Pharmacology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Stem Cells Dev 18:793-802. 2009..Moreover, we observed differential expression of Pontin52 and beta-catenin-proteins known to interact with Reptin52... - The dynamic stress-induced "O-GlcNAc-ome" highlights functions for O-GlcNAc in regulating DNA damage/repair and other cellular pathwaysNatasha E Zachara
The Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205 2185, USA
Amino Acids 40:793-808. 2011..Numerous proteins with diverse functions were identified, including NF-90, RuvB-like 1 (Tip49?), RuvB-like 2 (Tip49?), and several COPII vesicle transport proteins... - Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamilyH Shiraga
Department of Pediatrics, University of Pennsylvania, Philadelphia
Proc Natl Acad Sci U S A 89:426-30. 1992..and acidic amino acid content of this aspartic acid-rich protein, uropontin, are similar to those of other pontin proteins from bone, plasma, breast milk, and cells... - Probabilistic assembly of human protein interaction networks from label-free quantitative proteomicsMihaela E Sardiu
Stowers Institute for Medical Research, Kansas City, MO 64110, USA
Proc Natl Acad Sci U S A 105:1454-9. 2008..To demonstrate the application of this method to small-scale datasets, we analyzed an expanded human TIP49a and TIP49b dataset... - E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1Stefan Taubert
DNAX Research Institute, Palo Alto, California 94304, USA
Mol Cell Biol 24:4546-56. 2004..unrelated HAT Tip60 and induced recruitment of five subunits of the Tip60 complex (Tip60, TRRAP, p400, Tip48, and Tip49) to target promoters in vivo... - Nuclear proteome analysis of monkey embryonic stem cells during differentiationDavood Nasrabadi
Department of Molecular Systems Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, P O Box 19395 4644, Karaj, Iran
Stem Cell Rev 6:50-61. 2010..regulation, apoptosis, cell proliferation, and differentiation were identified including CTBP1, MM-1, RUVBL1, HCC-1, SGTA, SUMO2, and Galectin-1... - Reptin52 expression during in vitro neural differentiation of human embryonic stem cellsMiguel Barthelery
Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, United States
Neurosci Lett 452:47-51. 2009..In that regard, co-immunoprecipitation experiments showed that binding partners of Reptin52 (Pontin52, beta-catenin and ATF-2) associate with this regulatory protein in hESC-derived neuronal precursors... - Negative regulation of hypoxic responses via induced Reptin methylationJason S Lee
Department of Biological Sciences, Seoul National University, Seoul 151 742, South Korea
Mol Cell 39:71-85. 2010..Methylated Reptin binds to the promoters of a subset of hypoxia-responsive genes and negatively regulates transcription of these genes to modulate cellular responses to hypoxia... - Alternative oligomeric states of the yeast Rvb1/Rvb2 complex induced by histidine tagsKevin L Y Cheung
Department of Biochemistry and Biomedical Sciences and M G DeGroote Institute for Infectious Diseases Research, Health Sciences Center, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
J Mol Biol 404:478-92. 2010b>Rvb1 and Rvb2 are essential AAA(+) (ATPases associated with diverse cellular activities) helicases, which are important components of critical complexes such as chromatin remodeling and telomerase complexes... - Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair processMasamitsu Negishi
Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
Genes Cells 14:1347-57. 2009..These findings indicate that Dmap1 is required to involve Pcna in DNA repair. Together, Dmap1 plays a crucial role in DNA repair, and is indispensable for the maintenance of chromosomal integrity... - Structural and functional insights into a dodecameric molecular machine - the RuvBL1/RuvBL2 complexSabine Gorynia
Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
J Struct Biol 176:279-91. 2011b>RuvBL1 (RuvB-like 1) and its homolog RuvBL2 are evolutionarily highly conserved AAA(+) ATPases essential for many cellular activities. They play an important role in chromatin remodeling, transcriptional regulation and DNA damage repair... - Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complexNatsuko Izumi
Department of Molecular Biology, School of Medicine, Yokohama City University, Yokohama, Japan
Cancer Sci 103:50-7. 2012..In addition, Hsp90 forms complexes with RUVBL1/2 complex and Tel2 complex, both of which have been shown to interact with all PIKK and control their abundance .. - Unilateral nevoid telangiectasia accompanied by neurological disordersA Akman-Karakaş
Department of Dermatology and Venerology, Akdeniz University, School of Medicine Antalya, Turkey
J Eur Acad Dermatol Venereol 25:1356-9. 2011..Unilateral nevoid telangiectasia (UNT) is a unique vascular dermatosis of ambiguous aetiology... - Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organizationAndrew B Fielding
Department of Cancer Genetics, British Columbia Cancer Research Centre of the British Columbia Cancer Agency, Vancouver, BC, Canada
J Cell Biol 180:681-9. 2008..alpha- and beta-tubulin, ch-TOG (XMAP215), and RUVBL1 associate with ILK and colocalize with it to mitotic centrosomes... - Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulationRongmin Zhao
Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
J Cell Biol 180:563-78. 2008..Tah1 and Pih1 bind to the essential helicases Rvb1 and Rvb2 to form the R2TP complex, which we demonstrate is required for the correct accumulation of box C/D small .. - Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene controlSoda Balla Diop
Institut de Biologie du Developpement de Marseille Luminy, CNRS UMR6216 Université de la Méditerranée, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France
EMBO Rep 9:260-6. 2008b>Pontin (Pont) and Reptin (Rept) are paralogous ATPases that are evolutionarily conserved from yeast to human. They are recruited in multiprotein complexes that function in various aspects of DNA metabolism... - The human Ino80 binds to microtubule via the E-hook of tubulin: implications for the role in spindle assemblyEun Jung Park
Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Republic of Korea
Biochem Biophys Res Commun 416:416-20. 2011..human INO80 chromatin remodeling complex, comprising the Ino80 ATPase (hIno80) and the associated proteins such as Tip49a, has been implicated in a variety of nuclear processes other than transcription... - AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decayNatsuko Izumi
Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama, Japan
Sci Signal 3:ra27. 2010..The adenosine triphosphatases associated with diverse cellular activities (AAA+) family proteins RuvB-like 1 (RUVBL1) and RUVBL2 are involved in various cellular processes, including transcription, RNA modification, DNA repair, and .. - Lack of effect of RuvB-like proteins on DNA damage signaling activationAnastas Gospodinov
Institute of Molecular Biology, Bulgarian Academy of Sciences, Acad G Bonchev str 21, Sofia 1113, Bulgaria
Z Naturforsch C 65:148-52. 2010..The RuvB-like proteins TIP48 and TIP49 are known to be necessary for the assembly and functional activity of the TIP60 acetyltransferase complex... - Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcriptionSajid Rashid
Laboratory of Cell Biology, International Institute of Molecular and Cell Biology, Ks Trojdena 4, 02 109 Warsaw, Poland
J Biol Chem 284:18115-28. 2009..We propose that APPL proteins exert their stimulatory effects on beta-catenin/TCF-dependent transcription by decreasing the activity of a Reptin-containing repressive complex... - Enriching protein-protein and functional interaction networks in human embryonic stem cellsChangqing Zuo
Institute of Genetic Engineering, Southern Medical University, Guangzhou, Guangdong 510515, People s Republic of China
Int J Mol Med 23:811-9. 2009..Of the top 5% highly connected nodes (corresponding to 21 proteins including MYC, H2AFX, RUVBL1, DDX18, CDC2, HDAC2 and HIST1H4C) presumably critical for determining the fate of hESCs, nearly half are known to .. - Rvb1-Rvb2: essential ATP-dependent helicases for critical complexesJennifer Huen
Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada
Biochem Cell Biol 88:29-40. 2010b>Rvb1 and Rvb2 are highly conserved, essential AAA+ helicases found in a wide range of eukaryotes... - Architecture of the pontin/reptin complex, essential in the assembly of several macromolecular complexesEva Torreira
Centro de Investigaciones Biológicas Centre for Biological Research, Spanish National Research Council CSIC, Ramiro de Maeztu, 9, 28040 Madrid, Spain
Structure 16:1511-20. 2008b>Pontin and reptin belong to the AAA+ family, and they are essential for the structural integrity and catalytic activity of several chromatin remodeling complexes... - High-performance affinity chromatography method for identification of L-arginine interacting factors using magnetic nanobeadsMasaki Hiramoto
Department of Aging Intervention, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
Biomed Chromatogr 24:606-12. 2010..The data presented here demonstrate that L-AME-immobilized beads are effective tool for purification of AIFs directly from crude cell extracts. We expect that the present method can be used to purify AIFs from various types of cells... - Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanismValérie Haurie
Institut National de la Sante et de la Recherche Medicale, U889 Bordeaux, France
Hepatology 50:1871-83. 2009Reptin and Pontin are related ATPases associated with stoichiometric amounts in several complexes involved in chromatin remodeling, transcriptional regulation, and telomerase activity... - Cloning, expression, purification, crystallization and preliminary X-ray analysis of the human RuvBL1-RuvBL2 complexSabine Gorynia
ITQB Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Apartado 127, 2781 901 Oeiras, Portugal
Acta Crystallogr Sect F Struct Biol Cryst Commun 64:840-6. 2008The complex of RuvBL1 and its homologue RuvBL2, two evolutionarily highly conserved eukaryotic proteins belonging to the AAA(+) (ATPase associated with diverse cellular activities) family of ATPases, was co-expressed in Escherichia coli... - Identification of the Phr-dependent heat shock regulon in the hyperthermophilic archaeon, Thermococcus kodakaraensisTamotsu Kanai
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo ku, Kyoto, Japan
J Biochem 147:361-70. 2010..The Tk-Phr regulon included genes encoding sHSP, AAA(+) ATPase, prefoldin, RecA superfamily ATPase and Tip49. On the other hand, more than half of the members in the regulon encoded conserved/hypothetical proteins, raising .. - Pontin and reptin, two related ATPases with multiple roles in cancerOtmar Huber
Department of Laboratory Medicine and Pathobiochemistry, Charite Universitatsmedizin Berlin, Berlin, Germany
Cancer Res 68:6873-6. 2008..in model organisms or cultured human cells suggest potential implications in carcinogenesis for the AAA+ ATPases Pontin and Reptin... - [Significance and expression of S100A9 and NMP238 in cervical carcinoma tissues with different concurrent chemoradiotherapy sensitivities]Hong Zhu
Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China
Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:45-51. 2010To determine the significance and expression of S100A9 and NMP238 in cervical carcinoma with different concurrent chemoradiotherapy sensitivities. - Comparison of the multiple oligomeric structures observed for the Rvb1 and Rvb2 proteinsKevin L Y Cheung
Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, ON, L8N3Z5, Canada
Biochem Cell Biol 88:77-88. 2010The Rvb1 and Rvb2 proteins are 2 members of the AAA+ family, involved in roles as diverse as chromatin remodeling, transcription, small nucleolar RNA maturation, cellular transformation, signaling of apoptosis and mitosis... - Regulation of microtubule assembly and organization in mitosis by the AAA+ ATPase PontinDaniel Ducat
Department of Embryology, Carnegie Institution for Science and Howard Hughes Medical Institute, Baltimore, MD 21210, USA
Mol Biol Cell 19:3097-110. 2008..We carried out in-depth analyses of one of these proteins, Pontin, which is known to have several functions in interphase, including chromatin remodeling, DNA repair, and .. - SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cellsJung Hwa Kim
Department of Biological Sciences, Research Center for Functional Cellulomics and School of Agricultural Biotechnology, Seoul National University, Seoul 151 742, South Korea
Proc Natl Acad Sci U S A 104:20793-8. 2007..Here, we report that pontin, a component of chromatin-remodeling complexes, is SUMO-modified, and that SUMOylation of pontin is an active .. - Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complexYong Cai
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
J Biol Chem 278:42733-6. 2003..Taken together, our findings shed new light on the structure and function of the mammalian TRRAP/TIP60 histone acetyltransferase complex... - Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complexNicholas J Watkins
Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, D 37070 Gottingen, Germany
Mol Cell 16:789-98. 2004..that contain the core box C/D proteins as well as many non-snoRNP factors linked to snoRNP assembly (TIP48, TIP49, Nopp140), RNA processing (TGS1, La, LSm4, hRrp46), and subcellular localization (CRM1, PHAX)... - Rvb1p/Rvb2p recruit Arp5p and assemble a functional Ino80 chromatin remodeling complexZophonias O Jonsson
University of Virginia School of Medicine, Jordan 1240, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
Mol Cell 16:465-77. 2004The Rvb1p and Rvb2p (or TIP48 and TIP49) nuclear ATP binding proteins are universally conserved in eukaryotes and essential for viability of yeasts... - Expression of Xenopus homologs of the beta-catenin binding protein pontin52C Etard
Abt Biochemie, Universitat Ulm, Germany
Mech Dev 94:219-22. 2000Identification of pontin52 as an interaction partner of the Wnt/Wg signal transducer beta-catenin implicated a role for this protein in Wnt signaling... - Chromosome mapping and expression of human tip49 family genesY Makino
Faculty of Science, Chiba University, Japan
DNA Seq 11:145-8. 2000..was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b... - TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodelingYing Feng
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Cancer Res 63:8726-34. 2003..Factors cooperating with beta-catenin in transcription of TCF-regulated genes are not well defined. TIP49, an ATPase previously implicated as a cofactor for oncogenic transformation by c-Myc, has been shown to bind to .. - Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49aMary L Carlson
Huntsman Cancer Institute and the Department of Oncological Sciences, University of Utah, USA
Mol Cancer 2:42. 2003..cancer cell line, and in patients, is associated with overexpression of the Wnt pathway-associated proteins, Pontin52/TIP49a and LEF-1... - Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49aS B Hawley
Department of Vascular Biology CVN 26, Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 276:179-86. 2001..Two separate amino acid sequences were obtained and were identical to sequences contained within human and rat TIP49a. The cDNA for the 54-kDa protein matched the human TIP49a sequence, and encoded a COOH-terminal lysine, consistent .. - Signaling through beta-catenin and Lef/TcfA Novak
Cancer Research, S 218, Sunnybrook Health Science Centre, Toronto, Ontario, Canada
Cell Mol Life Sci 56:523-37. 1999..In the final step of the beta-catenin-Lef/Tcf signaling pathway, nuclear beta-catenin binds pontin52-TATA binding protein and displaces Groucho-related gene or CREB-binding protein corepressors from Lef/Tcf .. - The Saccharomyces cerevisiae RuvB-like protein, Tih2p, is required for cell cycle progression and RNA polymerase II-directed transcriptionC R Lim
Research and Education Center for Genetic Information and the Division of Gene Function in Animals, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara 630 0101, Japan
J Biol Chem 275:22409-17. 2000Two highly conserved RuvB-like putative DNA helicases, p47/TIP49b and p50/TIP49a, have been identified in the eukaryotes. Here, we study the function of Saccharomyces cerevisiae TIH2, which corresponds to mammalian p47/TIP49b... - Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNPNicholas J Watkins
Max Planck Institut fur biophysikalische Chemie, Abteilung Zelluläre Biochemie, D 37070, Gottingen, Germany
Mol Cell Biol 22:8342-52. 2002..remaining snoRNP-associated proteins, namely, NOP56, NOP58, fibrillarin, and the nucleoplasmic proteins TIP48 and TIP49. Stem II of the box C/D motif, in contrast to the U4 5' stem-loop, is highly conserved, and we show that this .. - Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1Anjana Saxena
Institute for Cancer Genetics, Department of Pathology, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
J Biol Chem 277:49935-44. 2002..However, its biochemical function is unknown. The closest paralogue of Ipl is Tih1, another small PH domain protein... - An evolutionarily conserved mediator of plant disease resistance gene function is required for normal Arabidopsis developmentBen F Holt
Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
Dev Cell 2:807-17. 2002..We describe an RPM1-interacting protein that is an ortholog of TIP49a, previously shown to interact with the TATA binding protein (TBP) complex and to modulate c-myc- and beta-catenin-.. - A notable example of an evolutionary conserved gene: studies on a putative DNA helicase TIP49Y Kurokawa
Department of Biology, Faculty of Science, Chiba University, Japan
DNA Seq 10:37-42. 1999b>TIP49a (just called as simply TIP49 in previous reports [Kanemaki et al., 1997; Makino et al., 1998]) was found in a rat nuclear protein complex that included the TATA-binding protein... - Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1Christelle Etard
Zoologisches Institut II, Universitat Karlsruhe TH, Kaiserstrasse 12, 76131 Karlsruhe, Germany
Mech Dev 122:545-56. 2005b>Pontin (Tip49) and Reptin (Tip48) are highly conserved components of multimeric protein complexes important for chromatin remodelling and transcription... - Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila developmentPaola Bellosta
Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Proc Natl Acad Sci U S A 102:11799-804. 2005..function by analyzing its interaction with the putative transcriptional cofactors Tip48/Reptin (Rept) and Tip49/Pontin (Pont). We demonstrate that Rept and Pont have conserved their ability to bind to Myc during evolution... - The AAA+ superfamily--a myriad of motionsPaul A Tucker
EMBL Hamburg Outstation, c o DESY, Notkestrasse 85, D22603 Hamburg, Germany
Curr Opin Struct Biol 17:641-52. 2007..Structural highlights in the processes mentioned are provided by work on ClpX and p97, ClpB, PspF and NtrC, RuvBL1, DnaA and the papillomavirus E1 initiator protein and dynein... - Trigenomic chromosomes by recombination of Thinopyrum intermedium and Th. ponticum translocations in wheatL Ayala Navarrete
CSIRO Plant Industry, Canberra, ACT, Australia
Theor Appl Genet 116:63-75. 2007..The molecular markers developed in this study will facilitate selection of individuals carrying recombinant Th. intermedium-Th. ponticum translocations (Pontin series) in breeding programs. - YY1 functions with INO80 to activate transcriptionYong Cai
Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
Nat Struct Mol Biol 14:872-4. 2007..Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters... - Control of transcription by Pontin and ReptinPeter Gallant
Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Trends Cell Biol 17:187-92. 2007b>Pontin and Reptin are two closely related members of the AAA+ family of DNA helicases. They have roles in diverse cellular processes, including the response to DNA double-strand breaks and the control of gene expression... - An eukaryotic RuvB-like protein (RUVBL1) essential for growthX B Qiu
Division of Molecular Oncology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 273:27786-93. 1998A human protein (RUVBL1), consisting of 456 amino acids (50 kDa) and highly homologous to RuvB, was identified by using the 14-kDa subunit of replication protein A (hsRPA3) as bait in a yeast two-hybrid system... - Genome-wide transcriptional analysis of flagellar regeneration in Chlamydomonas reinhardtii identifies orthologs of ciliary disease genesViktor Stolc
Genome Research Facility, National Aeronautic and Space Administration, Ames Research Center, Moffett Field, CA 94035, USA
Proc Natl Acad Sci U S A 102:3703-7. 2005..also identifies a number of important disease-related proteins as being involved with cilia and flagella, including the zebrafish polycystic kidney genes Qilin, Reptin, and Pontin, as well as the testis-expressed tubby-like protein TULP2. - Identification and characterization of the ubiquitously occurring nuclear matrix protein NMP 238K Holzmann
Institute of Tumor Biology Cancer Research, University of Vienna, Borschkegasse 8a, Vienna, A 1090, Austria
Biochem Biophys Res Commun 252:39-45. 1998..patterns of nuclear matrix proteins an ubiquitously occurring (common) nuclear matrix protein, termed NMP 238, was detected... - The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activityJörg Weiske
Department of Laboratory Medicine and Pathobiochemistry, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
J Biol Chem 281:27356-66. 2006..In this respect, we have recently shown that Hint1, by interaction with Pontin and Reptin, inhibits T-cell factor/beta-catenin-mediated transcription of Wnt target genes... - Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional programNathan P Gomes
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Genes Dev 20:601-12. 2006..Thus, select genes within the p53 pathway bypass the requirement for P-TEFb and RNAP II phosphorylation to trigger a cellular response to inhibition of global mRNA synthesis... - A mammalian chromatin remodeling complex with similarities to the yeast INO80 complexJingji Jin
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
J Biol Chem 280:41207-12. 2005The mammalian Tip49a and Tip49b proteins belong to an evolutionarily conserved family of AAA+ ATPases... - [Osteopontin, a multi-faceted molecule]Dorothee Chabas
INSERM U 546, Faculté de Médecine Pitié Salpêtrière, Paris, France
Med Sci (Paris) 21:832-8. 2005..been long considered a structural bone protein linking bone cells to the bone extracellular matrix (osteo : bone, pontin : bridge). It has been cloned for the first time in 1986... - Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteinsU Salzer
Institute of Biochemistry, Medical Faculty, University of Vienna, Austria
Biochim Biophys Acta 1446:365-70. 1999..2% amino acid identity) and contain ATP-binding sites. ECP-54 was identified as TIP49/RUVBL1/NMP238, which is a component of a large nuclear protein complex, possibly the RNA polymerase II holoenzyme; ECP-51 is a .. - TIP49, homologous to the bacterial DNA helicase RuvB, acts as an autoantigen in humanY Makino
Department of Biology, Faculty of Science, Chiba University, Japan
Biochem Biophys Res Commun 245:819-23. 1998..We have isolated a novel human cDNA for a 49-kD TBP-interacting protein (TIP49)... - The p400 complex is an essential E1A transformation targetM Fuchs
Dana Farber Cancer Institute, Boston, MA, USA
Cell 106:297-307. 2001..Furthermore, E1A and c-myc each alter the subunit composition of p400 complexes, implying that physiological p400 complex formation contributes to transformation suppression... - Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysisLibin Jia
Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Genomics 79:7-17. 2002..It is expected that high-throughput EST sequencing and data mining analysis will greatly promote our understanding of gene expression in these cells and of growth and development of the skeleton... - BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformationJeonghyeon Park
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
Mol Cell Biol 22:1307-16. 2002..reported the identification and functional characterization of four different c-Myc cofactors: TRRAP, hGCN5, TIP49, and TIP48...
Research Grants
- REGULATION OF FIBRINOLYSIS BY CELL SURFACELindsey Miles; Fiscal Year: 2002..2-dimensional gel analysis we identified a previously unrecognized candidate plasminogen receptor of monocytes, TIP49. We obtained protein and cDNA sequence information for TIP49 and the cDNA sequence predicted a carboxyl terminal ..
- Function of RVB1-Tip60 in the DNA damage responseAnindya Dutta; Fiscal Year: 2010..Recent results from our laboratory have implicated the RVB1 protein in the cellular response to DNA damage...
- MYC DEPENDENT PATHWAYS IN APOPTOSIS AND LYMPHOMAGENESISMichael Cole; Fiscal Year: 2003..The role of phosphorylation in c-Myc activity and the function of a newly isolated Myc-interacting factor, TIP49, will also be investigated...