RELN

Summary

Gene Symbol: RELN
Description: reelin
Alias: LIS2, PRO1598
Species: human

Top Publications

  1. ncbi A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    G D'ARCANGELO
    Roche Institute of Molecular Biology, Hoffman La Roche, Nutley, New Jersey 07110, USA
    Nature 374:719-23. 1995
  2. ncbi Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women
    Yaping Liu
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Psychiatr Genet 20:184-6. 2010
  3. ncbi No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression
    Heike Tost
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1379, USA
    Biol Psychiatry 68:105-7. 2010
  4. ncbi Further investigation of the association between rs7341475 and rs17746501 and schizophrenia
    Eyal Ben-David
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Am J Med Genet B Neuropsychiatr Genet 153:1244-7. 2010
  5. ncbi Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kindgdom
    PLoS Genet 4:e28. 2008
  6. ncbi Evolutionarily conserved, alternative splicing of reelin during brain development
    C Lambert de Rouvroit
    Neurobiology Unit, University of Namur School of Medicine, Namur, B 5000, Belgium
    Exp Neurol 156:229-38. 1999
  7. ncbi Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta
    Uwe Beffert
    Department of Molecular Genetics, Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    J Biol Chem 277:49958-64. 2002
  8. ncbi Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations
    S E Hong
    Division of Neurogenetics, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts, USA
    Nat Genet 26:93-6. 2000
  9. ncbi Methylation status of the reelin promoter region in the brain of schizophrenic patients
    Mamoru Tochigi
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Biol Psychiatry 63:530-3. 2008
  10. ncbi Identification of a single nucleotide polymorphism at the 5' promoter region of human reelin gene and association study with schizophrenia
    M-L Chen
    Mol Psychiatry 7:447-8. 2002

Research Grants

  1. EPIGENETIC MODIFICATIONS OF GABA NEURONS IN PSYCHOSIS
    Rajiv Sharma; Fiscal Year: 2007
  2. Role of alpha-Tubulin Mutations in Lissencephaly
    NICHOLAS COWAN; Fiscal Year: 2010
  3. MOLECULAR CONTROL OF CELL MIGRATION IN THE SPINAL CORD
    JOSEPH YIP; Fiscal Year: 2004
  4. Genetic Regulation of Neuronal Migration
    Anthony Wynshaw Boris; Fiscal Year: 2009
  5. Prenatal Virally Induced Brain Disorder in Mouse
    S Fatemi; Fiscal Year: 2007
  6. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
  7. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
  8. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
  9. GABAergic Dysfunction in Autism
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
  10. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED FATEMI; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications144 found, 100 shown here

  1. ncbi A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    G D'ARCANGELO
    Roche Institute of Molecular Biology, Hoffman La Roche, Nutley, New Jersey 07110, USA
    Nature 374:719-23. 1995
    ..The encoded protein resembles extracellular matrix proteins involved in cell adhesion. The reeler phenotype thus seems to reflect a failure of early events associated with brain lamination which are normally controlled by reelin...
  2. ncbi Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women
    Yaping Liu
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Psychiatr Genet 20:184-6. 2010
    A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case--control study specifically in women by Shifman et al...
  3. ncbi No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression
    Heike Tost
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1379, USA
    Biol Psychiatry 68:105-7. 2010
    A recent genome-wide association study linked a common variant in RELN (rs7341475G) with risk for schizophrenia in women...
  4. ncbi Further investigation of the association between rs7341475 and rs17746501 and schizophrenia
    Eyal Ben-David
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Am J Med Genet B Neuropsychiatr Genet 153:1244-7. 2010
    ....
  5. ncbi Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kindgdom
    PLoS Genet 4:e28. 2008
    ..We found a female-specific association with rs7341475, a SNP in the fourth intron of the reelin (RELN) gene (p = 2.9 x 10(-5) in women), with a significant gene-sex effect (p = 1.8 x 10(-4))...
  6. ncbi Evolutionarily conserved, alternative splicing of reelin during brain development
    C Lambert de Rouvroit
    Neurobiology Unit, University of Namur School of Medicine, Namur, B 5000, Belgium
    Exp Neurol 156:229-38. 1999
    ..Both alternative splicing events are present in mouse, rat, and man, suggesting that the corresponding reelin forms are functionally important...
  7. ncbi Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta
    Uwe Beffert
    Department of Molecular Genetics, Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    J Biol Chem 277:49958-64. 2002
    ....
  8. ncbi Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations
    S E Hong
    Division of Neurogenetics, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts, USA
    Nat Genet 26:93-6. 2000
    ..maps to chromosome 7q22, and is associated with two independent mutations in the human gene encoding reelin (RELN). The mutations disrupt splicing of RELN cDNA, resulting in low or undetectable amounts of reelin protein...
  9. ncbi Methylation status of the reelin promoter region in the brain of schizophrenic patients
    Mamoru Tochigi
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
    Biol Psychiatry 63:530-3. 2008
    Hypermethylation of the reelin (RELN) promoter region and the reduced levels of its messenger RNA and protein have been implicated in the pathophysiology of schizophrenia...
  10. ncbi Identification of a single nucleotide polymorphism at the 5' promoter region of human reelin gene and association study with schizophrenia
    M-L Chen
    Mol Psychiatry 7:447-8. 2002
  11. ncbi Population-based and family-based association study of 5'UTR polymorphism of the reelin gene and schizophrenia
    Celine Goldberger
    INSERM E117, Université de Paris 5, CH Sainte Anne, 2ter rue d Alesia, Paris, France
    Am J Med Genet B Neuropsychiatr Genet 137:51-5. 2005
    ..2 (CI = [1.4;12.4]). Our results weakly support an association of reelin gene variants with schizophrenia as a whole, yet suggest that reelin could be associated with treatment-resistant schizophrenia...
  12. ncbi Role of the reelin signaling pathway in central nervous system development
    D S Rice
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Neurosci 24:1005-39. 2001
    ..Recent studies have also suggested a role for the Reelin pathway in axonal branching, synaptogenesis, and pathology underlying neurodegeneration...
  13. ncbi Reelin is a serine protease of the extracellular matrix
    Carlo C Quattrocchi
    Laboratory of Neuroscience, Department of Physiology and Neuroscience, Università Campus Bio Medico, Via Longoni 83, 00155 Roma, Italy
    J Biol Chem 277:303-9. 2002
    ..The proteolytic activity of Reelin on adhesion molecules of the extracellular matrix and/or receptors on neurons may explain how Reelin regulates neuronal migration and synaptic plasticity...
  14. ncbi On the epigenetic regulation of the human reelin promoter
    Ying Chen
    Psychiatric Institute, Department of Psychiatry, 1601 West Taylor Street, M C 912, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Nucleic Acids Res 30:2930-9. 2002
    b>Reln mRNA and protein levels are reduced by approximately 50% in various cortical structures of post-mortem brain from patients diagnosed with schizophrenia or bipolar illness with psychosis...
  15. ncbi Association analysis of polymorphic CGG repeat in 5' UTR of the reelin and VLDLR genes with schizophrenia
    Akihisa Akahane
    Department of Psychiatry and Genome Research Center, Teikyo University School of Medicine, 11 1, Kaga 2 Chome, Itabashi, Tokyo 173 8605, Japan
    Schizophr Res 58:37-41. 2002
    ..We found no significant association of schizophrenia with the trinucleotide repeat polymorphism of the reelin or VLDLR genes, suggesting that these polymorphisms do not have a major role in the pathogenesis of the disease...
  16. ncbi Absence of association of a polymorphic GGC repeat at the 5' untranslated region of the reelin gene with schizophrenia
    Chia Hsing Huang
    Graduate Institute of Human Genetics, Tzu Chi University, Hualien City, 970 Taiwan
    Psychiatry Res 142:89-92. 2006
    ..Our findings do not support the involvement of the polymorphic GGC triplets of the reelin gene in the pathogenesis of schizophrenia in the population studied...
  17. ncbi A decrease of reelin expression as a putative vulnerability factor in schizophrenia
    F Impagnatiello
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 95:15718-23. 1998
    ..nuclei, and cerebella of schizophrenia patients and their matched nonpsychiatric subjects were compared for reelin (RELN) mRNA and reelin (RELN) protein content...
  18. ncbi Reelin promoter hypermethylation in schizophrenia
    Dennis R Grayson
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:9341-6. 2005
    ..Collectively, the data show that this promoter region has positive and negative properties and that the function of this complex cis element relates to its methylation status...
  19. ncbi Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1245-58. 2006
    ..Although, many other DISC1 binding partners still need to be investigated, these data implicate genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia...
  20. ncbi Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1
    David Benhayon
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Brain Res Mol Brain Res 112:33-45. 2003
    ..These findings demonstrate that ApoER2 and VLDLR are essential for Reelin signaling and that no other receptor molecules can compensate for their role in mediating tyrosine phosphorylation of Dab1...
  21. ncbi Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis
    S L Eastwood
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Mol Psychiatry 8:769, 821-31. 2003
    ..The alterations may contribute to the aberrant synaptic connectivity seen in schizophrenia. However, the functional implications of the abnormalities, as well as the mechanisms involved, remain to be fully elucidated...
  22. ncbi A truncated Reelin protein is produced but not secreted in the 'Orleans' reeler mutation (Reln[rl-Orl])
    V de Bergeyck
    Department of Physiology, FUNDP Medical School, Namur, Belgium
    Brain Res Mol Brain Res 50:85-90. 1997
    ..10 (1995) 77-83]. In the Orleans allele of reeler (symbol: Reln[rl-Orl]), a 220 nucleotide deletion is present in the 3' region of the Reelin message, resulting in a frame shift ..
  23. ncbi Low-density lipoprotein receptor-related protein 8 (LRP8) is upregulated in granulosa cells of bovine dominant follicle: molecular characterization and spatio-temporal expression studies
    Tania Fayad
    Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec, Canada J2S 7C6
    Biol Reprod 76:466-75. 2007
    ..0001). LRP8 protein was exclusively localized to the GC, with higher levels in the DF than in the SF (P<0.05). RELN mRNA, which encodes an LRP8 ligand, was highly expressed in the theca of the DF as compared to the OF (P<0...
  24. ncbi Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters
    E Dong
    Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 104:4676-81. 2007
    ..in GABAergic interneurons of mice exposed to protracted treatment with l-methionine (MET) is attributed to RELN and GAD(67) promoter cytosine-5-hypermethylation...
  25. ncbi Genetic malformations of cortical development
    Renzo Guerrini
    Epilepsy, Neurophysiology and Neurogenetics Unit, Division of Child Neurology and Psychiatry, University of Pisa and Research Institute Stella Maris Foundation, Via dei Giacinti 2, 56018, Calambrone, Pisa, Italy
    Exp Brain Res 173:322-33. 2006
    ..hypoplasia, accompanied by severe delay, hypotonia, and seizures, has been associated with mutations of the reelin (RELN) gene...
  26. ncbi Cerebellar gene expression profiles of mouse models for Rett syndrome reveal novel MeCP2 targets
    Charandle Jordan
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5323, USA
    BMC Med Genet 8:36. 2007
    ..Most mutations occur de novo during spermatogenesis. Located at Xq28, MECP2 is subject to X inactivation, and affected females are mosaic. Rare hemizygous males suffer from a severe congenital encephalopathy...
  27. ncbi Reelin expression in the retina and optic tectum of developing common brown trout
    Eva M Candal
    Department of Cell Biology and Ecology, Faculty of Biology, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Brain Res Dev Brain Res 154:187-97. 2005
    Reelin (RELN) is an extracellular matrix protein largely related with laminar organization in several brain areas...
  28. ncbi Multiple genes are hypermethylated in intraductal papillary mucinous neoplasms of the pancreas
    Seung Mo Hong
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Johns Hopkins University, Baltimore, MD 21231, USA
    Mod Pathol 21:1499-507. 2008
    ..Methylation-specific PCR was performed on isolated DNA for seven genes (SPARC, SARP2, TSLC1, RELN, TFPI2, CLDN5, UCHL1) known to be commonly aberrantly methylated in pancreatic ductal adenocarcinomas...
  29. ncbi Histological study in the brain of the reelin/Dab1-compound mutant mouse
    Tatsuro Yamamoto
    Division of Developmental Neurobiology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, 650 0017, Japan
    Anat Sci Int 84:200-9. 2009
    The Reelin (Reln)-deficient mouse (reeler) and the Dab1-deficient mouse (yotari) are autosomal recessive mutant mice characterized by cerebellar ataxia...
  30. ncbi Increased truncated TrkB receptor expression and decreased BDNF/TrkB signaling in the frontal cortex of reeler mouse model of schizophrenia
    Anilkumar Pillai
    Department of Psychiatry and Health Behavior, Medical College of Georgia and Medical Research Service, Veterans Affairs Medical Center, Augusta, GA 30907, USA
    Schizophr Res 100:325-33. 2008
    ..reelin, GAD67, GAD65, p75NTR, and NRH-2 levels were measured in the frontal cortex samples from reeler (B6C3Fe a/a-Reln rl/+) and wild-type (WT) mice. BDNF protein levels were significantly higher in reeler compared to WT...
  31. ncbi Neuronal migration disorders, genetics, and epileptogenesis
    Renzo Guerrini
    Epilepsy, Neurophysiology and Neurogenetics Unit, Division of Child Neurology and Psychiatry, University of Pisa and Research Institute, Stella Maris Foundation, Pisa, Italy
    J Child Neurol 20:287-99. 2005
    ..hypoplasia, accompanied by severe delay, hypotonia, and seizures, has been associated with mutations of the reelin (RELN) gene...
  32. ncbi Expression of p73 and Reelin in the developing human cortex
    Gundela Meyer
    Department of Anatomy, University La Laguna, 38071 Tenerife, Spain
    J Neurosci 22:4973-86. 2002
    Cajal-Retzius (CR) cells of the developing neocortex secrete Reelin (Reln), a glycoprotein involved in neuronal migration. CR cells selectively express p73, a p53 family member implicated in cell survival and apoptosis...
  33. ncbi Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study
    A Guidotti
    Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St, Room 256, Chicago, IL 60612, USA
    Arch Gen Psychiatry 57:1061-9. 2000
    Reelin (RELN) is a glycoprotein secreted preferentially by cortical gamma-aminobutyric acid-ergic (GABAergic) interneurons (layers I and II) that binds to integrin receptors located on dendritic spines of pyramidal neurons or on GABAergic ..
  34. ncbi Ectopic Reelin induces neuronal aggregation with a normal birthdate-dependent "inside-out" alignment in the developing neocortex
    Ken ichiro Kubo
    Department of Anatomy, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    J Neurosci 30:10953-66. 2010
    ..for this "inside-out" layering, because the layers are inverted in the Reelin-deficient mouse, reeler (Reln(rl))...
  35. ncbi Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration
    Naoya Yamashita
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 26:13357-62. 2006
    ..Here, we show evidence that CRMP1 is involved in Reelin (Reln) signaling to regulate neuronal migration in the cerebral cortex...
  36. ncbi The role of RELN in lissencephaly and neuropsychiatric disease
    Bernard S Chang
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Med Genet B Neuropsychiatr Genet 144:58-63. 2007
    ..Point mutations in the RELN gene have been shown to cause an autosomal recessive human brain malformation termed lissencephaly with cerebellar ..
  37. ncbi Gene-environment interaction during early development in the heterozygous reeler mouse: clues for modelling of major neurobehavioral syndromes
    Giovanni Laviola
    Sect Behavioral Neuroscience, Dept Cell Biology, Istituto Superiore di Sanita, Viale Regina Elena, 299, I 00161 Roma, Italy
    Neurosci Biobehav Rev 33:560-72. 2009
    ..Among candidate molecules, reelin (RELN) is a protein of the extracellular matrix playing a key role in brain development and synaptic plasticity...
  38. ncbi Genetic malformations of the cerebral cortex and epilepsy
    Renzo Guerrini
    Epilepsy, Neurophysiology and Neurogenetics Unit, Division of Child Neurology and Psychiatry, University of Pisa and Research Institute Stella Maris Foundation, Pisa, Italy
    Epilepsia 46:32-7. 2005
    ..hypoplasia; accompanied by severe delay, hypotonia, and seizures, has been associated with mutations of the RELN gene. Schizencephaly has a wide anatomoclinical spectrum, including focal epilepsy in most patients...
  39. ncbi Reln(rl-Alb2), an allele of reeler isolated from a chlorambucil screen, is due to an IAP insertion with exon skipping
    I Royaux
    Department of Physiology, FUNDP Medical School, Namur, Belgium
    Genomics 42:479-82. 1997
    The reeler Albany2 mutation (Reln(rl-Alb2) in the mouse is an allele of reeler isolated during a chlorambucil mutagenesis screen. Homozygous animals had drastically reduced concentrations of reelin mRNA, in which an 85-nt exon was absent...
  40. ncbi Genomic characterization and expression of mouse prestin, the motor protein of outer hair cells
    Jing Zheng
    Auditory Physiology Laboratory The Hugh Knowles Center, Department of Communication Sciences and Disorders, Northwestern University, Frances Searle Building, 2240 Campus Drive, Evanston, Illinois 60208, USA
    Mamm Genome 14:87-96. 2003
    ..Chromosome (Chr) 5, we concluded that the mPres gene is centromerically related to and resides within 19 kb of, the Reln gene...
  41. ncbi The phenotypic characteristics of heterozygous reeler mouse
    P Tueting
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 60612, USA
    Neuroreport 10:1329-34. 1999
    Histological and behavioral traits are associated with reelin (Reln) haplo-insufficiency in heterozygous reeler mouse (rl+/-)...
  42. ncbi [Epileptogenic brain malformations: radiological and clinical presentation and indications for genetic testing]
    N Bahi-Buisson
    Service de Neurologie Pediatrique, Departement de Pediatrie, Hopital Necker Enfants Malades, AP HP, Paris V, 149, rue de Sevres, 75015 Paris, France
    Rev Neurol (Paris) 164:995-1009. 2008
    ..LCHa are related with mutation in LIS1 or DCX, LCHb with mutation of RELN gene, and LCHd could be related with TUBA1A gene...
  43. ncbi Development of the cerebellar body in sharks: spatiotemporal relations of Pax6 expression, cell proliferation and differentiation
    Isabel Rodríguez-Moldes
    Department of Cell Biology and Ecology, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Neurosci Lett 432:105-10. 2008
    ..species by immunohistochemistry with antibodies against proliferating cell nuclear antigen (PCNA), Pax6, reelin (RELN), GABA, glutamic acid decarboxylase (GAD) and calretinin (CR)...
  44. ncbi Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis
    Irfan A Qureshi
    Rosyln and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    Neurobiol Dis 39:53-60. 2010
    ..g., GluR2, GLRA2, and GLRA3), growth factors (e.g., BDNF), extracellular matrix proteins (e.g., RELN), and diverse transcriptional regulators (e.g., CREB, c-fos, and c-jun)...
  45. ncbi Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression
    C Pesold
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago IL, 60612, USA
    Proc Natl Acad Sci U S A 96:3217-22. 1999
    Reelin (Reln) is a protein with some structural analogies with other extracellular matrix proteins that functions in the regulation of neuronal migration during the development of cortical laminated structures...
  46. ncbi Neocortical RELN promoter methylation increases significantly after puberty
    Carla Lintas
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, IRCCS Fondazione Santa Lucia, Rome, Italy
    Neuroreport 21:114-8. 2010
    Reelin plays a pivotal role in neurodevelopment. Excessive RELN promoter methylation and/or decreased RELN gene expression have been described in schizophrenia and autism...
  47. ncbi The Reelin (RELN) gene is associated with executive function in healthy individuals
    Bernhard T Baune
    Department of Psychiatry and Psychiatric Neuroscience, School of Medicine and Dentistry, James Cook University, QLD, Australia
    Neurobiol Learn Mem 94:446-51. 2010
    ..We aimed to investigate the association between genetic variants of the Reelin (RELN) gene and cognitive set-shifting in healthy young individuals...
  48. ncbi Selective disarrangement of the rostral telencephalic cholinergic system in heterozygous reeler mice
    S Sigala
    Section of Pharmacology, Department of Biomedical Sciences and Biotechnology, University of Brescia Medical School, V le Europa 11, 25123 Brescia, Italy
    Neuroscience 144:834-44. 2007
    Reelin (RELN) is a key molecule for the regulation of neuronal migration in the developing CNS. The reeler mice, which have spontaneous autosomal recessive mutation in the RELN gene, reveal multiple defects in brain development...
  49. ncbi Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia
    E Dong
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:12578-83. 2005
    ..expression in cortical GABAergic interneurons of SZ brains is the consequence of an epigenetic hypermethylation of RELN and GAD67 promoters very likely mediated by the overexpression of DNA methyltransferase 1 in cortical GABAergic ..
  50. ncbi Reelin-deficient mice show impaired neurogenesis and increased stroke size
    Seok Joon Won
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Exp Neurol 198:250-9. 2006
    Reelin (Reln) is a protein involved in migration of newborn neurons during development...
  51. ncbi Lack of Reelin causes malpositioning of nigral dopaminergic neurons: evidence from comparison of normal and Reln(rl) mutant mice
    Shigeyuki Nishikawa
    Laboratory of Neurobiology, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto 860 8556, 1 1 1 Honjo, Japan
    J Comp Neurol 461:166-73. 2003
    The reeler gene (Reln(rl), formerly rl) product Reelin controls neuronal migration and positioning and thereby plays a key role in brain development...
  52. ncbi Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex
    M A Rodriguez
    Psychiatric Institute, Department of Psychiatry, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 97:3550-5. 2000
    The expression of telencephalic reelin (Reln) and glutamic acid decarboxylase mRNAs and their respective cognate proteins is down-regulated in postmortem brains of schizophrenia and bipolar disorder patients...
  53. ncbi Rat neurological disease creeping is caused by a mutation in the reelin gene
    Norihide Yokoi
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, 260 8670, Japan
    Brain Res Mol Brain Res 112:1-7. 2003
    Reelin (Reln) is an extracellular matrix protein secreted from distinct neuronal populations and controls neural cell positioning during brain development...
  54. ncbi Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain
    D S Rice
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Development 125:3719-29. 1998
    Mutation of either reelin (Reln) or disabled-1 (Dab1) results in widespread abnormalities in laminar structures throughout the brain and ataxia in reeler and scrambler mice...
  55. ncbi Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Curr Biol 10:877-85. 2000
    The extracellular protein Reln controls neuronal migrations in parts of the cortex, hippocampus and cerebellum. In vivo, absence of Reln correlates with up-regulation of the docking protein Dab1 and decreased Dab1 tyrosine phosphorylation...
  56. ncbi FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5065, USA
    Carcinogenesis 31:1417-23. 2010
    ..17-1.81]. Associations were observed for SNPs in FGFR2, LSP1, H19, TLR1/TLR6 and RELN for AA; FGFR2, TNRC9, H19 and MAP3K1 for Whites; FGFR2, TNRC9, Msc5A1 and chromosome 8q for women > or =50 years ..
  57. ncbi Polymorphisms of candidate genes in Slovak autistic patients
    Silvia Kelemenova
    Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Psychiatr Genet 20:137-9. 2010
    ..on oxytocin (OT), oxytocin receptor (OXTR), GABA receptor gamma 3 (GABRG3), neuroligin (NLGN4X), and reelin (RELN). After signed consent, 90 autistic boys and 85 healthy controls were enrolled in the study...
  58. ncbi Reelin-induced tyrosine [corrected] phosphorylation of disabled 1 during neuronal positioning
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 USA
    Genes Dev 13:643-8. 1999
    The reelin (reln) and disabled 1 (dab1) genes both ensure correct neuronal positioning during brain development. We have found that the intracellular Dab1 protein receives a tyrosine phosphorylation signal from extracellular Reln protein...
  59. ncbi Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration
    Sergi Simo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 30:5668-76. 2010
    ..Correct layering requires an extracellular protein, Reelin (Reln), an intracellular signaling molecule, Disabled-1 (Dab1), and an E3 ubiquitin ligase, Cullin-5 (Cul5)...
  60. ncbi Reelin controls position of autonomic neurons in the spinal cord
    J W Yip
    Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 97:8612-6. 2000
    Mutation of the reeler gene (Reln) disrupts neuronal migration in several brain regions and gives rise to functional deficits such as ataxic gait and trembling in the reeler mutant mouse...
  61. ncbi Valproate induces DNA demethylation in nuclear extracts from adult mouse brain
    Erbo Dong
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL, USA
    Epigenetics 5:730-5. 2010
    ..DNA demethylation activity in postmitotic neuronal or glial cells, we incubated an SssI methylated mouse reelin (Reln) promoter fragment (-720 to +140) with nuclear extracts from the mouse frontal cortex (FC)...
  62. ncbi Neuronal migration disorders
    Renzo Guerrini
    Pediatric Neurology and Neurogenetics Unit and Laboratories, Children s Hospital A Meyer, University of Florence, Florence, Italy
    Neurobiol Dis 38:154-66. 2010
    ..Abnormalities of the LIS1, DCX, ARX, TUBA1A and RELN genes have been associated with these malformations...
  63. ncbi Regional brain variations of cytochrome oxidase activity in Relnrl-orl mutant mice
    C Strazielle
    Universite Henri Poincare, Nancy I, Laboratoire de Pathologie Moléculaire et Cellulaire en Nutrition EMI INSERM 0014, Vandoeuvre les Nancy, France
    J Neurosci Res 83:821-31. 2006
    ..The metabolic consequences of this form of neuropathology were examined in Reln(rl) mutant mice by quantitative measures of cytochrome oxidase (CO) activity, a mitochondrial enzyme essential for ..
  64. ncbi A pachygyria-causing alpha-tubulin mutation results in inefficient cycling with CCT and a deficient interaction with TBCB
    Guoling Tian
    Department of Biochemistry, New York University Medical Center, New York, NY 10016, USA
    Mol Biol Cell 19:1152-61. 2008
    ..In addition to mutations in at least four genes--LIS1, DCX, ARX and RELN--mutations in a human alpha-tubulin gene, TUBA1A, have recently been identified that cause these diseases...
  65. ncbi Pafah1b2 mutations suppress the development of hydrocephalus in compound Pafah1b1; Reln and Pafah1b1; Dab1 mutant mice
    Amir H Assadi
    The Cain Foundation Laboratories, Texas Children s Hospital, Houston, TX 77030, USA
    Neurosci Lett 439:100-5. 2008
    ..The data indicate that the two Pafah1b Alpha subunits have profoundly different effects on brain development and interact in a significantly different manner with the Reelin signaling pathway...
  66. ncbi Midbrain-hindbrain involvement in lissencephalies
    Patrice Jissendi-Tchofo
    Department of Radiology, University of California, San Francisco, CA, USA
    Neurology 72:410-8. 2009
    ....
  67. ncbi Genomic organization of the mouse reelin gene
    I Royaux
    Department of Physiology, University of Namur School of Medicine, Belgium
    Genomics 46:240-50. 1997
    ..The reelin gene (symbol Reln) codes for a protein of the extracellular matrix that contains eight successive repeats of 350 to 390 amino acids...
  68. ncbi Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope
    Hamid M Abdolmaleky
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, Massachusetts, USA
    Am J Pharmacogenomics 5:149-60. 2005
    ..Recent studies have indicated that epigenetic modification of reelin (RELN), BDNF, and the DRD2 promoters confer susceptibility to clinical psychiatric conditions...
  69. ncbi Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence
    Sheila P Gregorio
    Laboratório de Neurociências LIM 27, Departmento e Instituto de Psiquiatria, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    Psychiatry Res 165:1-9. 2009
    ..For reelin (RELN), a protease that guides neurons in the developing brain and underlies neurotransmission and synaptic plasticity in ..
  70. ncbi Embryonic and early fetal development of the human neocortex
    G Meyer
    Department of Anatomy, Faculty of Medicine, University La Laguna, 38071 La Laguna Tenerife, Spain
    J Neurosci 20:1858-68. 2000
    ..and early fetuses from Carnegie stages 16 to 22 (5-8 gestational weeks) by using immunohistochemistry for Reelin (Reln), calretinin (CR), and glutamic acid decarboxylase (GAD)...
  71. ncbi Axonal secretion of Reelin by Cajal-Retzius cells: evidence from comparison of normal and Reln(Orl) mutant mice
    P Derer
    Laboratoire du Développement et Vieillissement du Système Nerveux DVSN, FRE 2371 Neurobiologie des Processus Adaptatifs, CNRS et Universite P et M Curie, Paris Cedex 05, France
    J Comp Neurol 440:136-43. 2001
    A novel secretory pathway has been identified in the study of mice homozygous for the Reln(Orl) mutation, a line characterised by the defective secretion of the large extracellular matrix glycoprotein Reelin...
  72. ncbi Immune transcriptome alterations in the temporal cortex of subjects with autism
    Krassimira Garbett
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37203 USA
    Neurobiol Dis 30:303-11. 2008
    ..Critical expression changes were confirmed by qPCR (BCL6, CHI3L1, CYR61, IFI16, IFITM3, MAP2K3, PTDSR, RFX4, SPP1, RELN, NOTCH2, RIT1, SFN, GADD45B, HSPA6, HSPB8 and SERPINH1)...
  73. ncbi New neurochemical markers for psychosis: a working hypothesis of their operation
    A Guidotti
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 60612, USA
    Neurochem Res 25:1207-18. 2000
    Reelin (Reln) is expressed in specific GABAergic neurons in layer I and II of neocortex, and is secreted into the extracellular matrix where it surrounds dendrites, spines and neurite arborizations, and binds to integrin receptors located ..
  74. ncbi The evolution of cortical development. An hypothesis based on the role of the Reelin signaling pathway
    I Bar
    Neurobiology Unit, University of Namur, School of Medicine, 61 rue de Bruxelles, B 5000, Namur, Belgium
    Trends Neurosci 23:633-8. 2000
    ..Thus, the Reelin pathway played a key role in cortical architectonic evolution in mammalian and squamate lineages...
  75. ncbi [Development and developmental disorders of the human brain. III. Neuronal migration disorders of the cerebrum]
    H J ten Donkelaar
    Instituut voor Neurologie, Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 145:466-74. 2001
    ..can be divided into a number of syndromes, each of which is characterised by a gene mutation (LIS1, DCX, RELN). These mutations result in agyria and pachygyria, which are characteristic for this group...
  76. ncbi Neuronal migration disorders: clinical, neuroradiologic and genetics aspects
    Alberto Spalice
    Department of Paediatrics, Division of Child Neurology, University of Rome La Sapienza, Italy
    Acta Paediatr 98:421-33. 2009
    ..Six different genes could be responsible for this entity (LIS1, DCX, TUBA1A, VLDLR, ARX, RELN), although co-delection of YWHAE gene with LIS1 could result in Miller-Dieker Syndrome...
  77. ncbi Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
    T Hiesberger
    Department of Molecular Genetics, UT Southwestern Dallas, Texas 75235, USA
    Neuron 24:481-9. 1999
    ..Taken together, these findings suggest that Reelin acts via VLDLR and ApoER2 to regulate Disabled-1 tyrosine phosphorylation and microtubule function in neurons...
  78. ncbi The genetic variation of RELN expression in schizophrenia and bipolar disorder
    Galit Ovadia
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 6:e19955. 2011
    ..between reelin and psychiatric disorders, we studied the factors that influence the expression of reelin gene (RELN) and its different isoforms...
  79. ncbi Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration
    Aycan Sentürk
    Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max von Laue Str 9, D 60438, Frankfurt am Main, Germany
    Nature 472:356-60. 2011
    ..The secreted glycoprotein Reelin (also known as RELN) guides migration of neurons by binding to two lipoprotein receptors, the very-low-density lipoprotein receptor (..
  80. ncbi Impact of early developmental arsenic exposure on promotor CpG-island methylation of genes involved in neuronal plasticity
    Liborio Martínez
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de San Luis Potosi, Av V Carranza 2405, C P 78210 San Luis Potosí, Mexico
    Neurochem Int 58:574-81. 2011
    ..immunohistochemistry and methylation-specific polymerase chain reaction (PCR) of the promoter regions of reelin (RELN) and protein phosphatase 1 (PP1) at 1, 2, 3 and 4 months of age...
  81. ncbi Genetic and epigenetic alteration in gastric carcinogenesis
    Carlos Resende
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias s n, Porto, Portugal
    Helicobacter 15:34-9. 2010
    ..activation (MYC, SEMA5A, BCL2L12, RBP2 and BUBR1) and tumor suppressor gene inactivation mechanisms (KLF6, RELN, PTCH1A, CLDN11, and SFRP5)...
  82. ncbi Role of cytoskeletal abnormalities in the neuropathology and pathophysiology of type I lissencephaly
    Gaelle Friocourt
    INSERM, U613, Brest, France
    Acta Neuropathol 121:149-70. 2011
    ..Genetic alterations of LIS1, DCX, ARX, TUBA1A, VLDLR, RELN and more recently WDR62 genes cause migrational abnormalities along with more complex and subtle anomalies ..
  83. ncbi Lack of association between SNP rs3914132 of the RELN gene and otosclerosis in India
    S Priyadarshi
    Institute of Life Sciences, Nalco Square, Chandrashekarpur, Bhubaneswar, India
    Genet Mol Res 9:1914-20. 2010
    ..7371), and rs10227303 (P = 0.5669) were not significantly associated with this disease. In one familial case, a novel variant (C/T) at contig position 2923488 was found to be inherited by the proband and affected family members...
  84. ncbi Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelin
    D Goldowitz
    Department of Anatomy and Neurobiology, University of Tennessee College of Medicine, Memphis, Tennessee 38163, USA
    J Neurosci 17:8767-77. 1997
    ..However, the scrambler locus has been mapped to a site distinct from that of reelin (Reln), the gene responsible for the reeler defect...
  85. ncbi Genetic variants in RELN are associated with otosclerosis in a non-European population from Tunisia
    Ayda Khalfallah
    Unite Cibles pour le Diagnostic et la Therapie, Centre de Biotechnologie de Sfax, Tunisie
    Ann Hum Genet 74:399-405. 2010
    ..1, located in the RELN gene, and one on chr11q13.1...
  86. ncbi The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 19:5179-88. 1999
    ..In mice, the Dab1 protein is thought to function downstream of the extracellular protein Reln during neuronal positioning...
  87. ncbi Development of patient-specific neurons in schizophrenia using induced pluripotent stem cells
    Erika Pedrosa
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York 10416, USA
    J Neurogenet 25:88-103. 2011
    ..factors/chromatin remodeling proteins and synaptic proteins relevant to SZ pathogenesis, including ZNF804A, RELN, CNTNAP2, CTNNA2, SMARCA2, and NRXN1...
  88. ncbi Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression
    Ekrem Maloku
    Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 107:4407-11. 2010
    ..This finding suggests that lack of reelin impairs GABAergic Purkinje neuron expression and/or positioning during cerebellar development...
  89. ncbi Cortical layer development and orientation is modulated by relative contributions of reelin-negative and -positive neurons in mouse chimeras
    Vicki E Hammond
    Howard Florey Institute, University of Melbourne, Parkville 3010, Victoria, Australia
    Cereb Cortex 20:2017-26. 2010
    ....
  90. ncbi Replication of association between working memory and Reelin, a potential modifier gene in schizophrenia
    Juho Wedenoja
    Institute for Molecular Medicine Finland FIMM, University of Helsinki and National Institute for Health and Welfare, Helsinki, Finland
    Biol Psychiatry 67:983-91. 2010
    ..in Finnish families and demonstrated that an intragenic short tandem repeat (STR) allele of the regional Reelin (RELN) gene is associated with multiple cognitive traits representing central cognitive functions regarded as valid ..
  91. ncbi Controversies in RELN/reelin expression in otosclerosis
    Péter Csomor
    Department of Otolaryngology and Head and Neck Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Nagyerdei krt 98, 4032, Hungary
    Eur Arch Otorhinolaryngol 269:431-40. 2012
    ..have reported a potential genetic association between disease-specific single nucleotide polymorphism (SNPs) of RELN and otosclerosis and confirmed RELN expression in human stapes footplates...
  92. ncbi Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease
    Jeannie Chin
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 27:2727-33. 2007
    ..We conclude that alterations in Reelin processing or signaling may be involved in AD-related neuronal dysfunction...
  93. ncbi Reelin mouse mutants as models of cortical development disorders
    GABRIELLA D'ARCANGELO
    The Cain Foundation Laboratories, Texas Children s Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Epilepsy Behav 8:81-90. 2006
    ..The regulation of the Reelin gene may thus provide insights into the mechanisms of this disease...
  94. ncbi Reelin down-regulation in mice and psychosis endophenotypes
    Patricia Tueting
    Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street Chicago, IL 60612, USA
    Neurosci Biobehav Rev 30:1065-77. 2006
    ..Recent findings indicate that the reelin (RELN) and GAD67 promoters are hypermethylated in GABAergic neurons of psychotic postmortem brain and that DNA ..
  95. ncbi Neuronal migration and the role of reelin during early development of the cerebral cortex
    Yves Jossin
    Developmental Neurobiology Unit, University of Louvain Medical School, Brussels, Belgium
    Mol Neurobiol 30:225-51. 2004
    ....
  96. ncbi Reelin glycoprotein: structure, biology and roles in health and disease
    S H Fatemi
    Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, 420 Delaware Street, Minneapolis, MN 55455, USA
    Mol Psychiatry 10:251-7. 2005
    ..Disruption of Reelin signaling pathway by mutations and selective hypermethylation of the Reln gene promoter or following various pre- or postnatal insults may lead to cognitive deficits present in ..
  97. ncbi Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease
    Javier Saez-Valero
    Instituto de Neurociencias, UMH CSIC, Campus de San Juan, San Juan, Alicante, Spain
    J Neurosci Res 72:132-6. 2003
    ..7 +/- 6.7 arbitrary units; a.u.) and AD (151.4 +/- 3.8 a.u.) compared with control individuals (141.4 +/- 1.2 a.u., P < 0.05). Our results strongly suggest the involvement of reelin signaling in neurodegenerative pathologies...
  98. ncbi Expression and localization of reelin in human odontoblasts
    Jean Christophe Maurin
    Laboratoire du Developpement des Tissus Dentaires, EA 1892, IFR 62, Faculté d Odontologie, Rue Guillaume Paradin, 69372 CEDEX08 Lyon, France
    Matrix Biol 23:277-85. 2004
    ..On the basis of these data, we suggest that reelin might be an extracellular matrix molecule involved in the terminal innervation of the dentin-pulp complex, promoting adhesion between dental nerve endings and odontoblasts...
  99. ncbi Neurobehavioral evaluation of Reln-rl-orl mutant mice and correlations with cytochrome oxidase activity
    R Lalonde
    Faculte de Medecine et de Pharmacie, Universite de Rouen, 22 bld Gambetta, INSERM EMI 9906, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France
    Neurosci Res 49:297-305. 2004
    The Reln-rl-orl mutation is characterized by a marked deficit in cerebellar granule cell and Purkinje cell number as well as ectopias in cerebellum, hippocampus, and neocortex...
  100. ncbi Lack of evidence for an association between WNT2 and RELN polymorphisms and autism
    Jun Li
    Department of Genetics M344, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Am J Med Genet B Neuropsychiatr Genet 126:51-7. 2004
    ..Several recent candidate gene studies have suggested that alleles of WNT2 and the reelin gene (RELN), two genes involved in distinct aspects of neurodevelopment, confer greater susceptibility to autism...
  101. ncbi Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade
    Nobutaka Ohkubo
    Department of Physiology, School of Medicine, Ehime University, Onsen gun, Ehime 791 0295, Japan
    FASEB J 17:295-7. 2003
    ..Mice lacking Reelin (Reln), double-knockouts lacking the VLDL receptor (VLDLR) and ApoE receptor2 (ApoER2), and mice lacking disabled-1 (Dab1)..

Research Grants71

  1. EPIGENETIC MODIFICATIONS OF GABA NEURONS IN PSYCHOSIS
    Rajiv Sharma; Fiscal Year: 2007
    ..Reelin (RELN), GAD67 and DNA methylating enzyme (DNMT1) are all expressed in GABA interneurons, and are each abnormally ..
  2. Role of alpha-Tubulin Mutations in Lissencephaly
    NICHOLAS COWAN; Fiscal Year: 2010
    ..Mutations in at least three genes - LIS1, DCX and RELN - lead to very similar defects in neuronal migration that are associated with the disease...
  3. MOLECULAR CONTROL OF CELL MIGRATION IN THE SPINAL CORD
    JOSEPH YIP; Fiscal Year: 2004
    ..A gene that has been found to influence neuronal migration in the brain of the mouse is the reeler gene (reln)...
  4. Genetic Regulation of Neuronal Migration
    Anthony Wynshaw Boris; Fiscal Year: 2009
    ..three major functional pathways, based on genetic, biochemical and cell biological studies in mouse models: the RELN pathway, the Cdk5/p35 pathway and the LIS1 pathway...
  5. Prenatal Virally Induced Brain Disorder in Mouse
    S Fatemi; Fiscal Year: 2007
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  6. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  7. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  8. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  9. GABAergic Dysfunction in Autism
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  10. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  11. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  12. GABAergic and Reelin Deficits in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..subjects with bipolar disorder, major depression, and matched controls. Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development. ..
  13. Mouse models for GABA epigenetic dysfunction
    Alessandro Guidotti; Fiscal Year: 2007
    ..abstract_text> ..
  14. NEUROSTEROIDS: PHYSIOLOGICAL RELEVANCE
    Alessandro Guidotti; Fiscal Year: 1999
    ....
  15. Mouse models for GABA epigenetic dysfunction
    Alessandro Guidotti; Fiscal Year: 2009
    ..abstract_text> ..
  16. REELIN DEFICIENCY--MODEL FOR SCHIZOPHRENIA VULNERABILITY
    Alessandro Guidotti; Fiscal Year: 2004
    ..brain structures are known to follow an unusually complex course of embryological developmental in which RELN plays a pivotal signaling role...
  17. PHARMACOLOGY--ALLOSTERIC MODULATORS OF GABAA RECEPTORS
    Alessandro Guidotti; Fiscal Year: 2002
    ....
  18. Reelin and GAD67 Downregulation
    Erminio Costa; Fiscal Year: 2005
    ..mRNAs were correlated in the PFC of NP and UD, and wild-type mouse frontal cortex but not S, BDP, or heterozygous RELN+/-...
  19. Regulation of the Reelin Gene
    Dennis Grayson; Fiscal Year: 2006
    ..Secondly, we will also focus on the role that DNA methylation plays in defining reelin gene (RELN) expression in neuronal precursors differentiating in vitro (Aim 2)...
  20. GABAergic molecular pathology in schizophrenia
    Erminio Costa; Fiscal Year: 2007
    ....