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Genomes and Genes | PTK6SummaryGene Symbol: PTK6 Description: PTK6 protein tyrosine kinase 6 Alias: BRK, breast tumor kinase, protein-tyrosine kinase 6, protein-tyrosine kinase BRK, tyrosine-protein kinase BRK Species: human Top Publications
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Identification of STAT3 as a specific substrate of breast tumor kinaseL Liu
Department of Microbiology and Molecular Genetics, Stony Brook University, Stony Brook, NY 11794 8691, USA
Oncogene 25:4904-12. 2006b>Breast tumor kinase (Brk) is a non-receptor tyrosine kinase distantly related to the Src family kinase. It is expressed in more than 60% of breast tumors, but the biological role of this kinase remains to be determined...- Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinasesMichael S Serfas
University of Illinois College of Medicine, Department of Molecular Genetics, Chicago, IL 60607, USA
Oncol Res 13:409-19. 2003The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases, including one another... - Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factorYu Zheng
University of Illinois, Department of Biochemistry and Molecular Genetics, Chicago, IL 60607, USA
Mol Cell Biol 30:4280-92. 2010b>Protein tyrosine kinase 6 (PTK6) is a nonmyristoylated Src-related intracellular tyrosine kinase... - Brk protects breast cancer cells from autophagic cell death induced by loss of anchorageAmanda J Harvey
Brunel Institute for Cancer Genetics and Pharmacogenomics, Biosciences, School of Health Sciences and Social Care, Brunel University, Kingston Lane, Uxbridge, Middlesex, United Kingdom
Am J Pathol 175:1226-34. 2009b>Brk, a tyrosine kinase expressed in a majority of breast tumors, but not normal mammary tissue, promotes breast carcinoma cell proliferation... - Regulated association of protein kinase B/Akt with breast tumor kinasePing Zhang
University of Minnesota Cancer Center and the Department of Medicine, Division of Hematology, Oncology, and Transplantation, and Pharmacology, Minneapolis, Minnesota 55455, USA
J Biol Chem 280:1982-91. 2005..b>Breast tumor kinase (Brk) is a soluble protein-tyrosine kinase overexpressed in the majority of breast cancers and also in .. - Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinaseH Lee
Department of Biochemistry, College of Science, and Bioproducts Research Center, Yonsei University, Seoul, Korea
Mol Cells 8:401-7. 1998Partial PTK6 (also known as Brk) cDNA was initially isolated by reverse transcription-PCR of normal human melanocyte mRNAs and the full-length cDNA encodes a non-receptor protein tyrosine kinase with an SH3 domain, an SH2 domain, and a .. - A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytesS T Lee
Department of Medical Genetics, University of Wisconsin, Madison 53706
Oncogene 8:3403-10. 1993..We mapped 16 of the corresponding protein tyrosine kinase genes to specific human chromosomes, identifying a total of 19 human genetic loci, some of which may constitute candidate genes for genetic disorders of mammalian development... - Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6Helena L Palka-Hamblin
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
J Cell Sci 123:236-45. 2010Disruption of the gene encoding protein tyrosine kinase 6 (PTK6) leads to increased growth, impaired enterocyte differentiation and higher levels of nuclear beta-catenin in the mouse small intestine... - Structural basis of the auto-inhibition mechanism of nonreceptor tyrosine kinase PTK6Sunggeon Ko
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Republic of Korea
Biochem Biophys Res Commun 384:236-42. 2009b>Protein tyrosine kinase 6 (PTK6) is composed of SH3, SH2, and Kinase domains, with a linker region (Linker) between the SH2 and Kinase domains... - PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1Shin Ae Kang
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
J Biol Chem 285:26013-21. 2010b>PTK6 (also known as Brk) is a non-receptor-tyrosine kinase containing SH3, SH2, and catalytic domains, that is expressed in more than 60% of breast carcinomas but not in normal mammary tissues... - Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cellsJason J Derry
Department of Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
Oncogene 22:4212-20. 2003b>Breast tumor kinase (BRK) is an intracellular tyrosine kinase expressed in differentiating epithelial cells of the gastrointestinal tract and skin, and in several epithelial cancers including carcinomas of the breast and colon... - A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRKP J Mitchell
Section of Cell Biology and Experimental Pathology, The Breakthrough Toby Robinson Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
Oncogene 19:4273-82. 2000The brk gene encodes a non-receptor tyrosine kinase that has been found to be overexpressed in approximately two thirds of breast tumours... - Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migrationKiven E Lukong
Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal Quebec, Canada
Cell Signal 20:432-42. 2008b>BReast tumor Kinase (BRK) also known as protein kinase 6 (PTK6) is a nonreceptor tyrosine kinase overexpressed in the majority of human breast tumors... - Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylationT Kamalati
School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey, UK
Oncogene 19:5471-6. 2000..of human breast cancers, in contrast with normal mammary tissue, express the intracellular tyrosine kinase BRK. BRK expression enhances the mitogenic response of mammary epithelial cells to epidermal growth factor, and .. - Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6Amanda M Weaver
Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
Breast Cancer Res 9:R79. 2007..Breast tumor kinase (Brk), also known as protein tyrosine kinase 6, is a nonreceptor tyrosine kinase expressed in more than 60% of breast cancers... - BRK/Sik expression in the gastrointestinal tract and in colon tumorsX Llor
Department of Molecular Genetics, University of Illinois College of Medicine, Chicago 60607, USA
Clin Cancer Res 5:1767-77. 1999Clones encoding the breast tumor kinase BRK were isolated from a normal human small intestinal cDNA library that was screened with the cDNA encoding the mouse epithelial-specific tyrosine kinase Sik... - BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrestKiven E Lukong
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Canada
Cell Signal 21:1415-22. 2009b>BReast tumor Kinase (BRK) also known as protein kinase 6 (PTK6) is a non-receptor tyrosine kinase overexpressed in the majority of human breast carcinoma. The expression of BRK is a known prognostic marker of breast carcinoma... - Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding abilityJ J Derry
Departments of Molecular Genetics and Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
Mol Cell Biol 20:6114-26. 2000Sik (mouse Src-related intestinal kinase) and its orthologue BRK (human breast tumor kinase) are intracellular tyrosine kinases that are distantly related to the Src family and have a similar structure, but they lack the myristoylation .. - Interaction between Brk kinase and insulin receptor substrate-4Haoqun Qiu
Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
Oncogene 24:5656-64. 2005b>Breast tumor kinase (Brk) is a member of the Frk family of nonreceptor tyrosine kinases that is overexpressed in a high percentage of human breast tumors. The downstream substrates and effectors of Brk remain largely unidentified... - Overexpression of PTK6 (breast tumor kinase) protein--a prognostic factor for long-term breast cancer survival--is not due to gene amplificationMichaela Aubele
Institute of Pathology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
Virchows Arch 455:117-23. 2009In a previous retrospective study, we demonstrated the prognostic value of protein tyrosine kinase 6 (PTK6) protein expression in breast carcinomas... - Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factorT Kamalati
Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, United Kingdom
J Biol Chem 271:30956-63. 1996brk (breast tumor kinase) shows homology to the src family of non-receptor protein-tyrosine kinases and is expressed in breast carcinomas... - Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillinHsin Yi Chen
Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
Mol Cell Biol 24:10558-72. 2004Brk (for breast tumor kinase) is a nonreceptor tyrosine kinase containing SH3, SH2, and tyrosine kinase catalytic domains... - Oncogenic functions of PTK6 are enhanced by its targeting to plasma membrane but abolished by its targeting to nucleusHan Ie Kim
Department of Biochemistry, Yonsei University, Seoul, Republic of Korea
J Biochem 146:133-9. 2009b>PTK6 (also known as Brk) is an intracellular tyrosine kinase whose expression is up-regulated in several tumour types... - Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domainEunmi Hong
Department of Biochemistry and Protein Network Research Center, College of Science, Yonsei University, Seoul 120 749, Korea
J Biol Chem 279:29700-8. 2004Human protein-tyrosine kinase-6 (PTK6, also known as breast tumor kinase (Brk)) is a member of the non-receptor protein-tyrosine kinase family and is expressed in two-thirds of all breast tumors... - Role of the Brk SH3 domain in substrate recognitionHaoqun Qiu
Department of Physiology and Biophysics, Basic Science Tower, T 6, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
Oncogene 23:2216-23. 2004b>Breast tumor kinase (Brk) is a nonreceptor tyrosine kinase that is overexpressed in a high percentage of breast carcinomas. Brk contains SH3, SH2, and tyrosine kinase catalytic domains in a similar arrangement as Src family kinases... - Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumoursP J Mitchell
Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, UK
Oncogene 9:2383-90. 1994..and characterised a cDNA from a human metastatic breast tumour representing a novel protein tyrosine kinase (brk)... - Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progressionKiven Erique Lukong
Terry Fox Molecular Oncology Group and Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Department of Oncology, McGill University, Montreal, Quebec H3T 1E2, Canada
J Biol Chem 280:38639-47. 2005The breast tumor kinase (BRK) is a growth promoting non-receptor tyrosine kinase overexpressed in the majority of human breast tumors. BRK is known to potentiate the epidermal growth factor (EGF) response in these cells... - Characterization of the 5'-flanking region of the human PTK6 geneKyung Nam Kang
National Research Laboratory of Cellular Biochemistry, Department of Biochemistry, College of Science, and Protein Network Research Center, Yonsei University, 120 749, Seoul, South Korea
Biochim Biophys Acta 1574:365-9. 2002b>PTK6 (also known as Brk) is a non-receptor protein tyrosine kinase, whose mRNA was expressed in the limited normal tissues such as colon and small intestine, and in breast carcinomas and breast cancer cell lines... - Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRKJohn H Coyle
Myles H Thaler Center for AIDS and Human Retrovirus Research and Department of Microbiology, University of Virginia, Charlottesville 22908, USA
Mol Cell Biol 23:92-103. 2003..of Sam68 was inhibited in a dose-dependent manner by coexpression of an activated form of the nuclear kinase Sik/BRK that hyperphosphorylated Sam68... - The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2Andrea Haegebarth
Departments of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, USA
J Biol Chem 279:54398-404. 2004Expression of the intracellular tyrosine kinase BRK/Sik is epithelial-specific and regulated during differentiation... - Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibitionHaoqun Qiu
Department of Physiology and Biophysics, School of Medicine, State University of New York, Stony Brook, NY 11794 8661, USA
J Biol Chem 277:34634-41. 2002Brk (breast tumor kinase) is a nonreceptor tyrosine kinase that is most closely related to the Frk family of kinases, and more distantly to Src family kinases... - Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytesMonika Kasprzycka
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
Am J Pathol 168:1631-41. 2006..Here we describe constitutive expression of the protein tyrosine kinase Brk in a large proportion of cutaneous T-cell lymphomas and other transformed T- and B-cell populations... - Cloning and sequencing of a Bordetella pertussis serum resistance locusR C Fernandez
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Ohio 45267
Infect Immun 62:4727-38. 1994..We have named this locus brk, for Bordetella resistance to killing... - Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cellsPatrick M Brauer
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA
Cell Cycle 9:4190-9. 2010b>Protein tyrosine kinase 6 (PTK6) is an intracellular tyrosine kinase that is nuclear in epithelial cells of the normal prostate, but cytoplasmic in prostate tumors and in the PC3 prostate tumor cell line... - The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activityIvan Babic
Department of Biochemistry and Molecular Biology, University of Calgary, Calgary AB, Canada T2N 4N1
Oncogene 23:3781-9. 2004..Tyrosine phosphorylation by Src family kinases and breast tumor kinase can negatively regulate its RNA binding activity... - Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cellsB B Koenig
Corporate Research Division, Miami Valley Laboratories, Procter and Gamble Company, Cincinnati, Ohio 45239 8707
Mol Cell Biol 14:5961-74. 1994..This receptor has been named BRK-1 in recognition of its ability to bind BMP-2 and BMP-4 and its receptor kinase structure... - Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformationJanet Strath
Institute of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK
BMC Genomics 10:67. 2009.... - Induction of Fas (CD95/APO-1) ligand is essential for p53-dependent apoptosis in an in vitro renal carcinoma model systemToshihiko Okazaki
Walther Cancer Institute, Purdue Cancer Center, West Lafayette, Indiana, USA
J Cancer Res Clin Oncol 133:581-8. 2007.... - Noncanonical compensation of zygotic X transcription in early Drosophila melanogaster development revealed through single-embryo RNA-seqSusan E Lott
Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
PLoS Biol 9:e1000590. 2011..early zygotic dosage compensation results in nearly identical transcript levels for key X-linked developmental regulators, including giant (gt), brinker (brk), buttonhead (btd), and short gastrulation (sog), in male and female embryos. - The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of ?-cateninPatrick M Brauer
Department of Biochemistry and Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois, United States of America
PLoS ONE 6:e14789. 2011b>Protein tyrosine kinase 6 (PTK6), also called breast tumor kinase (BRK), is expressed in epithelial cells of various tissues including the prostate... - Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosisChen Zhao
Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Cancer 98:18-23. 2003..The aim of the current study was to identify specific genes in the 20q amplicon that were likely to have clinical significance... - Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinomaJulia L Zhong
Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom
Mol Cancer Res 6:383-94. 2008..and the adaptor molecules Grb2 and Tks5/Fish, but associate in an isoform-specific fashion with Nck and the Src and Brk tyrosine kinases... - Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cellsJulie Hanson Ostrander
Department of Medicine, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Cancer Res 67:4199-209. 2007..Breast tumor kinase (Brk; protein tyrosine kinase 6) is a soluble tyrosine kinase that was cloned from a metastatic breast tumor and found to be .. - Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestineAndrea Haegebarth
University of Illinois College of Medicine, Department of Biochemistry and Molecular Genetics, M C 669, 900 S Ashland Ave, Chicago, IL 60607, USA
Mol Cell Biol 26:4949-57. 2006b>Protein tyrosine kinase 6 (PTK6) (also called Brk or Sik) is an intracellular tyrosine kinase that is expressed in breast cancer and normal epithelial linings... - brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in DrosophilaOrna Cook
Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
Development 131:2113-24. 2004..examine the mechanism by which two broadly expressed Dpp signaling target genes, optomotor-blind (omb) and brinker (brk), collaborate to initiate formation of the fifth longitudinal (L5) wing vein... - Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosisAndrea Haegebarth
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA
Gastroenterology 137:945-54. 2009b>Protein tyrosine kinase 6 (PTK6) is expressed in epithelial linings of the gastrointestinal tract. PTK6 sensitizes the nontransformed Rat1a fibroblast cell line to apoptotic stimuli... - Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptorsT Nohno
Department of Pharmacology, Kawasaki Medical School, Japan
J Biol Chem 270:22522-6. 1995..This receptor (BRK-3) is distantly related to other known type II receptors and is distinguished from them by an extremely long .. - A sesquiterpenelactone from Inula britannica induces anti-tumor effects dependent on Bcl-2 phosphorylationMohamed M Rafi
Department of Food Science, New Jersey Agricultural Experimentation Station, Cook College, Rutgers University, New Brunswick, New Jersey 08901 8520, USA
Anticancer Res 25:313-8. 2005..Although initially active in clinical studies, current anti-microtubule agents are only temporarily effective and the discovery of new agents is warranted... - BMP signaling during bone pattern determination in the developing limbY Kawakami
Department of Molecular Biology, Kawasaki Medical School, Kurashiki, Japan
Development 122:3557-66. 1996To examine the role of BMP signaling during limb pattern formation, we isolated chicken cDNAs encoding type I (BRK-1 and BRK-2) and type II (BRK-3) receptors for bone morphogenetic proteins... - Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryoH L Ashe
Department of Molecular and Cell Biology, Division of Genetics and Development, University of California, Berkeley, CA 94720, USA
Development 127:3305-12. 2000..depend on a secreted inhibitor, Short gastrulation (Sog) and a newly identified transcriptional repressor, Brinker (Brk), which are expressed in neurogenic regions that abut the dorsal ectoderm... - Role of c-myc in the transformation of REF52 cells by viral and cellular oncogenesN E Kohl
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
Oncogene 2:41-8. 1987..In contrast, myc and E1A were similarly active as ras collaborators when assayed on primary baby rat kidney (BRK) cells... - PPS, a large multidomain protein, functions with sex-lethal to regulate alternative splicing in DrosophilaMatthew L Johnson
Department of Genetics, Case Western Reserve University, School of Medicine, Cleveland, Ohio, United States of America
PLoS Genet 6:e1000872. 2010..PPS encodes a large protein with four signature motifs, PHD, BRK, TFS2M, and SPOC, typically found in proteins involved in transcription... - Conditional gene activation in cultured hepatocytes using a ligand-dependent chimeric Cre recombinaseHuan Zhang Zhu
State Key Laboratory of Genetic Engineering, Institute of Genetic, School of Life Sciences, Fudan University, Shanghai 200433, China
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:435-40. 2003..gene promoter/enhancer, alb-Cre-ERt, was constructed, and transfected into engineering BRL (Rat hepatocytes) and BRK (Rat kidney) reporter cells which carries a chromosomally integrated 'floxed' beta geo gene, which is inserted .. - Identification of tyrosine kinases overexpressed in head and neck cancerHo Sheng Lin
Department of Otolaryngology Head and Neck Surgery, Wayne State University, Detroit, MI 48201, USA
Arch Otolaryngol Head Neck Surg 130:311-6. 2004..To identify protein-tyrosine kinases (PTKs) that may be involved in the development and progression of head and neck squamous cell carcinoma (HNSCC)... - Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesisS Bellusci
Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2175, USA
Development 122:1693-702. 1996..The Type I Bone morphogenetic protein receptor gene (Bmpr/Tfr-11/Brk-1) is expressed at low levels in the epithelium and in the distal mesenchyme... - Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputsC Rushlow
Department of Biology, New York University, New York, New York 10003, USA
Genes Dev 15:340-51. 2001..Dpp signal transducer p-Mad (phosphorylated Mad), together with the recently discovered negative regulator Brinker (Brk), define the spatial limits of zen transcription in a broad dorsal-on/ventral-off domain... - Conditionally immortalized colonic epithelial cell line from a Ptk6 null mouse that polarizes and differentiates in vitroRobert H Whitehead
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
J Gastroenterol Hepatol 23:1119-24. 2008b>PTK6 is an intracellular src-related tyrosine kinase that regulates differentiation in the intestine, where knockout animals have increased proliferative activity and growth characteristics... - Both of the N-terminal and C-terminal regions of human papillomavirus type 16 E7 are essential for immortalization of primary rat cellsT Yamashita
Department of Dermatology, Cancer Research Institute, Sapporo Medical University School of Medicine, Japan
J Investig Dermatol Symp Proc 6:69-75. 2001..79R of HPV16 E7, showed ras-collaboration activity in primary rat embryo fibroblast and primary baby rat kidney (BRK) cells as efficiently as HPV16 E7... - Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activityGalit Lazer
Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada IMRIC, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
J Biol Chem 285:23075-85. 2010..SH2 profiling revealed that Shc, Csk, Abl, and Sap associate with Tyr-826, whereas SH2-B, Src, Brk, GTPase-activating protein, and phospholipase C-gamma associate with Tyr-841... - Separation of immortalization and T24-ras oncogene cooperative functions of adenovirus E1aM Kuppuswamy
Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110
Oncogene 2:613-5. 1988..2 E1a gene coding for a protein of 243 (243R) amino acids can efficiently immortalize primary rat kidney (BRK) cells and cooperate with the activated cellular ras oncogene (T24 ras)... - Repression of Dpp targets in the Drosophila wing by BrinkerStephanie E Winter
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
Development 131:6071-81. 2004..the anteroposterior axis is restricted by lateral-to-medial gradients of the transcriptional repressor Brinker (Brk). omb is less sensitive to repression by Brk than sal and is consequently expressed more laterally... - Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosaW S Chen
Division of Colorectal Surgery, Department of Surgery, Veterans General Hospital, Taipei, Taiwan, Republic of China
Int J Cancer 83:579-84. 1999..30 tyrosine kinases expressed in these tissues: they include 10 non-receptor tyrosine kinases (yes, fyn, lyn, brk, abl, arg, jak1, jak3, tyk2 and itk), 17 receptor tyrosine kinases (erbB2, PDGF-Ralpha, PDGF-Rbeta, kit, c-fms, met,.. - Determinants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neckSusanne J Rogers
Tumour Biology and Metastasis Team, McElwain Laboratories, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, Sutton, Surrey, SM2 5NG, UK
J Pathol 218:122-30. 2009..Breast receptor kinase (BRK) was more highly expressed in the sensitive cell lines, but siRNA knockdown of neither BRK nor MET affected .. - Dissection of functional domains in the adenovirus 2 early 1B 55K polypeptide by suppressor-linker insertional mutagenesisP R Yew
Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024 1570
Virology 179:795-805. 1990..Transformation of BRK cells following DNA transfection was reduced by complete disruption of the 55K protein gene, but was not .. - Cloning and sequencing of the Bordetella pertussis cpn10/cpn60 (groESL) homologR C Fernandez
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, OH 45267, USA
Gene 158:151-2. 1995The nucleotide sequence downstream from the Bordetella resistance to killing (brk) locus in Bordetella pertussis was determined. Analysis of the sequence revealed an operon consisting of two highly predicted open reading frames (ORFs)... - Generating and interpreting the Brinker gradient in the Drosophila wingMelissa Moser
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
Dev Biol 286:647-58. 2005The transcription factor Brinker (Brk) represses gene expression in the Drosophila wing imaginal disc, where it is expressed in symmetrical lateral-to-medial gradients, a pattern that is established by inverse gradients of the TGF-beta, .. - The BRK tyrosine kinase is expressed in high-grade serous carcinoma of the ovaryRosemarie E Schmandt
Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230 1439, USA
Cancer Biol Ther 5:1136-41. 2006We identified the BRK tyrosine kinase in a PCR-based screen of tyrosine kinases expressed by ovarian tumors... - The role of brinker in mediating the graded response to Dpp in early Drosophila embryosA Jazwinska
Institut fuer Entwicklungsbiologie, Universitaet zu Koeln, Gyrhofstr 17, Germany
Development 126:3323-34. 1999Brinker (Brk), a novel protein with features of a transcriptional repressor, regulates the graded response to Decapentaplegic (Dpp) in appendage primordia of Drosophila... - Multiple modular promoter elements drive graded brinker expression in response to the Dpp morphogen gradientLi Chin Yao
Department of Developmental and Cell Biology and the Developmental Biology Center, University of California Irvine, Irvine, CA 92612, USA
Development 135:2183-92. 2008..Decapentaplegic (Dpp), the BMP2/4 homolog, downregulates transcription of the nuclear repressor brinker (brk) in a concentration-dependent manner to generate an inverse graded distribution... - Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cellsNancy E Castro
Department of Pharmacology, University of Minnesota, 321 Church Street S E, Minneapolis, MN 55455, USA
Breast Cancer Res 12:R60. 2010Breast tumor kinase (Brk/protein tyrosine kinase 6 (PTK6)) is a nonreceptor, soluble tyrosine kinase overexpressed in the majority of breast tumors... - Differential expression of tapasin and immunoproteasome subunits in adenovirus type 5- versus type 12-transformed cellsAlfred C O Vertegaal
Medical Genetic Centre Department of Molecular Cell Biology, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
J Biol Chem 278:139-46. 2003Adenovirus type 12 (Ad12)-transformed baby rat kidney (BRK) cells are oncogenic in syngeneic immunocompetent rats in contrast to adenovirus type 5 (Ad5)-transformed BRK cells, which are not oncogenic in these animals... - Brk/PTK6 signaling in normal and cancer cell modelsJULIE H OSTRANDER
Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, NC 27710, USA
Curr Opin Pharmacol 10:662-9. 2010b>Breast tumor kinase (Brk), also termed PTK6, is known to function in cell-type and context-dependent processes governing normal differentiation... - Molecular dissection of the interaction between the SH3 domain and the SH2-Kinase Linker region in PTK6Han Ie Kim
Department of Biochemistry, College of Science, Yonsei University, Seoul 120 749, Republic of Korea
Biochem Biophys Res Commun 362:829-34. 2007b>PTK6 (also known as Brk) is an intracellular tyrosine kinase that contains SH3, SH2, and tyrosine kinase catalytic (Kinase) domains... - RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRKPatrick M Brauer
Department of Biochemistry and Molecular Genetics, University of Illinois College of Medicine, Chicago, IL 60607, USA
Cell Cycle 8:2728-32. 2009..originally called RAK, is a member of a small family of intracellular Src-related tyrosine kinases that includes PTK6 and Srms. These kinases share a conserved gene structure that is distinct from that of the Src family... - Schnurri transcription factors from Drosophila and vertebrates can mediate Bmp signaling through a phylogenetically conserved mechanismLi Chin Yao
Department of Developmental and Cell Biology, and the Developmental Biology Center, University of California Irvine, Irvine, CA 92697, USA
Development 133:4025-34. 2006..Decapentaplegic (Dpp), by forming a Shn/Smad repression complex on defined promoter elements in the brinker (brk) gene. Brk is a transcriptional repressor that downregulates Dpp target genes... - The brinker gradient controls wing growth in DrosophilaFrancisco A MartÃn
Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid 28049, Spain
Development 131:4921-30. 2004..evidence indicating that the Dpp gradient is converted into an inverse gradient of activity of the gene brinker (brk), which encodes a transcriptional repressor and is negatively regulated by the Dpp pathway... - Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cellsOsamu Ikeda
Department of Immunology, Graduate School of Pharmaceutical Sciences Hokkaido University, Sapporo, Japan
Cancer Sci 102:756-61. 2011..that contains Pleckstrin homology and Src homology 2-like domains, and is also known to be a substrate of breast tumor kinase (Brk)... - PTK (protein tyrosine kinase)-6 and HER2 and 4, but not HER1 and 3 predict long-term survival in breast carcinomasM Aubele
GSF National Research Center for Environment and Health, Institute of Pathology, D 85764 Neuherberg, Germany
Br J Cancer 96:801-7. 2007..and prognostic significance in breast cancer, and their function is modulated by cytoplasmic tyrosine kinases like PTK6 (brk)... - Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradientBruno Muller
Institut fur Molekularbiologie, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Cell 113:221-33. 2003..Throughout development, Dpp transduction causes the graded transcriptional downregulation of the brinker (brk) gene... - The intracellular tyrosine kinase Brk sensitizes non-transformed cells to inducers of apoptosisAndrea Haegebarth
Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois, USA
Cell Cycle 4:1239-46. 2005The intracellular tyrosine kinase Brk is expressed in regenerating epithelial tissues with highest levels in the gastrointestinal tract and skin... - Global analysis of DNA methylation by Methyl-Capture sequencing reveals epigenetic control of cisplatin resistance in ovarian cancer cellWei Yu
Systems Biology Division, Zhejiang California International Nanosystems Institute ZCNI, Zhejiang University, Hangzhou, Zhejiang Providence, China
PLoS ONE 6:e29450. 2011..Methylation specific PCR and bisulfite sequencing confirmed hypermethylation of PTK6, PRKCE and BCL2L1 in A2780 compared with A2780CP... - Impact of protein tyrosine kinase 6 (PTK6) on human epidermal growth factor receptor (HER) signalling in breast cancerNatalie Ludyga
Institute of Pathology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
Mol Biosyst 7:1603-12. 2011b>PTK6, also known as Brk, is highly expressed in over 80% of breast cancers. In the last decade several substrates and interaction partners were identified localising PTK6 downstream of HER receptors... - Ras-induced resistance to lapatinib is overcome by MEK inhibitionGabriele Zoppoli
Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy
Curr Cancer Drug Targets 10:168-75. 2010..Moreover, genetic alterations that do not directly involve ras such as Brk amplification, ultimately result in increased ras signaling... - Deregulation of the cell cycle by breast tumor kinase (Brk)Edward Chan
Department of Pediatric Hematology Oncology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
Int J Cancer 127:2723-31. 2010b>Brk is a cytoplasmic nonreceptor tyrosine kinase that is overexpressed in breast tumors but undetectable in normal or benign mammary tissues... - A chemical and phosphoproteomic characterization of dasatinib action in lung cancerJiannong Li
Department of Thoracic Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Nat Chem Biol 6:291-9. 2010..These include SRC-family kinase (SFK) members (LYN, SRC, FYN, LCK and YES), nonreceptor tyrosine kinases (FRK, BRK and ACK) and receptor tyrosine kinases (Ephrin receptors, DDR1 and EGFR)... - Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRKPatrick M Brauer
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
Biochim Biophys Acta 1806:66-73. 2010b>Protein tyrosine kinase 6 (PTK6), also referred to as breast tumor kinase BRK, is a member of a distinct family of kinases that is evolutionarily related to the SRC family of tyrosine kinases... - Enhanced ras oncogene mediated cell transformation and tumorigenesis by adenovirus 2 mutants lacking the C-terminal region of E1a proteinT Subramanian
Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110
Oncogene 4:415-20. 1989..or 67 amino acids of a 243 amino acid (243R) protein are defective in immortalization of primary baby rat kidney (BRK) cells. However, they cooperate with T24 ras in oncogenic transformation more efficiently than wt... - Requirement of the C-terminal region of adenovirus E1a for cell transformation in cooperation with E1bT Subramanian
Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110
Oncogene 6:1171-3. 1991..cooperated more efficiently (than wt E1a) with activated T24 ras oncogene in transformation of primary rat kidney (BRK) cells (Subramanian et al., 1989; Oncogene, 4:415-420)... - Cell type dependent transformation by adenovirus 5 E1a proteinsM Kuppuswamy
Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110
Oncogene 2:567-72. 1988..We report here that these proteins have different cell transformation properties. Primary baby rat kidney (BRK) cells infected with an M-MuLV retrovirus vector that expresses the 243R protein are immortalized and the resulting .. - Induction by E1A oncogene expression of cellular susceptibility to lysis by TNFM J Chen
Department of Molecular Genetics, Smith Kline and French Laboratories, King of Prussia, Pennsylvania 19406
Nature 330:581-3. 1987..By using an in vitro cytotoxicity assay with NIH 3T3 and Fisher BRK-derived cells expressing exogenously introduced oncogenes, we found that adenovirus E1A proteins induce .. - Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytesJ Tupper
School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey, UK
Arch Dermatol Res 303:293-7. 2011b>Breast Tumor Kinase (Brk/PTK6) has a relatively limited expression profile in normal tissue... - PTK6 regulates IGF-1-induced anchorage-independent survivalHanna Y Irie
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 5:e11729. 2010..Anchorage-independent survival is induced by growth factor receptor hyperactivation in many cell types. We aimed to identify molecules that critically regulate IGF-1-induced anchorage-independent survival... - Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cellsOsamu Ikeda
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
J Biol Chem 285:38093-103. 2010..STAP-2 is also a substrate of breast tumor kinase (Brk). In breast cancers, Brk expression is deregulated and promotes STAT3-dependent cell proliferation... - Correlations between spatiotemporal changes in gene expression and apoptosis underlie wing polyphenism in the ant Pheidole morrisiSeba Jamal Shbailat
Department of Biology, McGill University, Montreal, QC, Canada
Evol Dev 12:580-91. 2010..We previously constructed a mathematical model, which predicts that a key gene brinker (brk) mediates the development and evolution of these different "interruption points" in wingless castes of .. - A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiationV Vasioukhin
Department of Molecular Genetics, M C 669, University of Illinois, 900 South Ashland Avenue, Chicago, IL 60607, USA
Proc Natl Acad Sci U S A 94:14477-82. 1997Sik, the mouse homologue of the breast tumor kinase Brk, is expressed in differentiating cells of the gastrointestinal tract and skin... - STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motifMayu Minoguchi
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
J Biol Chem 278:11182-9. 2003..STAP-2 is a murine homologue of a recently identified adaptor molecule, BKS, a substrate of BRK tyrosine kinase... - Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screenShigeru Yamada
Research Institute for Cell Engineering RICE, National Institute of Advanced Industrial Science and Technology AIST, Aomi 2 41 6, Kohtoh ku, Tokyo 135 0064, Japan
Biochem Biophys Res Commun 363:926-30. 2007.... - Solution structure of the BRK domains from CHD7Mark D Allen
MRC Centre for Protein Engineering, Hills Road, Cambridge, CB2 2QH, UK
J Mol Biol 371:1135-40. 2007..CHD7 is one of a subset of CHD proteins, unique to metazoans that contain the BRK domain, a protein module also found in the Brahma/BRG1 family of helicases... - Wingless directly represses DPP morphogen expression via an armadillo/TCF/Brinker complexHeidi Theisen
Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, United States of America
PLoS ONE 2:e142. 2007..We have shown that these mutually exclusive patterns of expression are controlled by a self-organizing system of feedback loops that involve WG and DPP, but whether the feedback is direct or indirect is not known... - Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK)Fatih M Uckun
Paradigm Pharmaceuticals, 2139 4th Street, White Bear Lake, MN 55110, USA
Bioorg Med Chem 15:800-14. 2007..kinases, including CDK1, CDK2, CDK3, CHK1, IKK, MAPK1 or SAPK2a, none of the 10 tyrosine kinases, including ABL, BRK, BMX, c-KIT, FYN, IGF1R, PDGFR, JAK2, MET, or YES, or the lipid kinase PI3Kgamma were inhibited (IC(50) values >200-.. - DNA recognition by the brinker repressor--an extreme case of coupling between binding and foldingFlorence Cordier
Division of Structural Biology, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
J Mol Biol 361:659-72. 2006The Brinker (Brk) nuclear repressor is a major element of the Drosophila Decapentaplegic morphogen signaling pathway. Its N-terminal part has weak homology to the Antennapedia homeodomain and binds to GC-rich DNA sequences...
Research Grants
- Brk interaction with ErbB receptors alters cell fateJulie Ostrander; Fiscal Year: 2006..The non-receptor protein tyrosine kinase (PTK), Brk, was cloned from a metastatic breast tumor and subsequently found expressed in approximately 65 percent of human ..
- SUBSTRATE SPECIFICITY OF NONRECEPTOR TYROSINE KINASESW Todd Miller; Fiscal Year: 2010..Aim 3 focuses on Brk (breast tumor kinase), a NRTK related to Src. In collaboration with Dr...
- SUBSTRATE SPECIFICITY OF NONRECEPTOR TYROSINE KINASESW Miller; Fiscal Year: 2009..Aim 3 focuses on Brk (breast tumor kinase), a NRTK related to Src. In collaboration with Dr...
- MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILAGerard Campbell; Fiscal Year: 2007..theory, a single RD could provide all the activity required for a TF to function, but real TFs such as the Brinker (Brk), Engrailed (En) and C15 proteins of Drosophila possess multiple RDs and appear to be able to recruit more than one ..
- MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILAGERARD L CAMPBELL; Fiscal Year: 2010..theory, a single RD could provide all the activity required for a TF to function, but real TFs such as the Brinker (Brk), Engrailed (En) and C15 proteins of Drosophila possess multiple RDs and appear to be able to recruit more than one ..
- MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILAGerard Campbell; Fiscal Year: 2009..theory, a single RD could provide all the activity required for a TF to function, but real TFs such as the Brinker (Brk), Engrailed (En) and C15 proteins of Drosophila possess multiple RDs and appear to be able to recruit more than one ..
- FUNCTION OF A NOVEL TYROSINE KINASE IN THE INTESTINEANGELA TYNER; Fiscal Year: 2005..The investigator identified the human homologue of Sik and determined that it is the breast tumor kinase BRK, which had been isolated from a metastatic breast tumor...
- Functions of the Brk Tyrosine Kinase in the Gastrointestinal TractAngela L Tyner; Fiscal Year: 2010..to identify genes that regulate intestinal epithelial cell differentiation led to the discovery of Brk (Breast tumor kinase, also called PTK6 and Sik)...
- Functions of the Brk Tyrosine Kinase in the Gastrointestinal TractANGELA TYNER; Fiscal Year: 2007..to identify genes that regulate intestinal epithelial cell differentiation led to the discovery of Brk (Breast tumor kinase, also called PTK6 and Sik)...
- Functions of the Brk Tyrosine Kinase in the Gastrointestinal TractANGELA TYNER; Fiscal Year: 2009..to identify genes that regulate intestinal epithelial cell differentiation led to the discovery of Brk (Breast tumor kinase, also called PTK6 and Sik)...
- BRK/Sik Tyrosine Kinase Signaling in the ProstateANGELA TYNER; Fiscal Year: 2009The intracellular epithelial-specific tyrosine kinase BRK/Sik belongs to a tyrosine kinase family whose members have growth inhibitory functions...
- Brk Signals to ERK5 in Breast CancerCAROL ANN LANGE; Fiscal Year: 2010..A novel nonreceptor PTK, termed breast tumor kinase (Brk) was cloned from a human metastatic breast tumor, and found to be overexpressed in human breast ..
- Sam 68 and the Function of Mason Pfizer Monkey Virus CTEMarie Louise Hammarskjold; Fiscal Year: 2007..Sam68 is also a substrate for Sik/Brk, a non-myristoylated member of the Src family that shows a mainly nuclear localization...
- CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKERGerard Campbell; Fiscal Year: 2004..control target gene expression: through negative regulation of a repressor of these targets encoded by the brinker (brk) gene...
- FUNCTION OF A NOVEL TYROSINE KINASE IN THE INTESTINEANGELA TYNER; Fiscal Year: 2000..that the human homologue of this kinase is a known protein previously identified in a metastatic breast tumor (Brk)...
- Brk Signals to ERK5 in Breast CancerCAROL ANN LANGE; Fiscal Year: 2011..A novel nonreceptor PTK, termed breast tumor kinase (Brk) was cloned from a human metastatic breast tumor, and found to be overexpressed in human breast ..
- Brk signal transduction in breast cancerCAROL LANGE; Fiscal Year: 2007..A novel nonreceptor PTK, termed breast tumor kinase (Brk) was cloned from a human metastatic breast tumor, and found to be overexpressed in human breast ..
- Regulation of STAT3 SignalingNANCY REICH; Fiscal Year: 2009..Specific Aim #2 is designed to evaluate the positive influence of breast tumor kinase, and the negative influence of the suppressor of cytokine signaling 3 (SOCS-3) on STAT3 function...
- Regulation of STAT3 SignalingNancy C Reich; Fiscal Year: 2010..Specific Aim #2 is designed to evaluate the positive influence of breast tumor kinase, and the negative influence of the suppressor of cytokine signaling 3 (SOCS-3) on STAT3 function...
- Studies on the Stem Cells of the Colonic MucosaRobert Whitehead; Fiscal Year: 2003..The identification of unique markers for the colonic stem cell will allow us to enrich for this cell population and undertake transplantation studies. ..