PRKCI

Summary

Gene Symbol: PRKCI
Description: protein kinase C, iota
Alias: DXS1179E, PKCI, nPKC-iota, PRKC-lambda/iota, aPKC-lambda/iota, atypical protein kinase C-lambda/iota, protein kinase C iota type
Species: human

Top Publications

  1. ncbi Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
    K Conant
    Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    J Virol 70:1384-9. 1996
  2. ncbi aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6
    Hitoshi Ishiguro
    Department of Urology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Proc Natl Acad Sci U S A 106:16369-74. 2009
  3. ncbi Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones
    Anastasia Mashukova
    Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Cell Sci 122:2491-503. 2009
  4. ncbi Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter
    W Clay Gustafson
    Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 279:9400-8. 2004
  5. ncbi Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms
    Atsushi Suzuki
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 239 0004
    J Biochem 133:9-16. 2003
  6. ncbi Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells
    Flavia A Wald
    Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL 33135, USA
    J Cell Sci 121:644-54. 2008
  7. ncbi Correlation of aPKC-iota and E-cadherin expression with invasion and prognosis of cholangiocarcinoma
    Qiang Li
    Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Hepatobiliary Pancreat Dis Int 7:70-5. 2008
  8. ncbi HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta
    Yamina Bennasser
    Laboratoire d Immuno Virologie, EA 3038, Universite Paul Sabatier, 31062 Toulouse, France
    FASEB J 16:546-54. 2002
  9. ncbi Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity
    Tomoyuki Yamanaka
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Japan
    Curr Biol 13:734-43. 2003
  10. ncbi Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62
    P Sanchez
    Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, Canto Blanco, Spain
    Mol Cell Biol 18:3069-80. 1998

Research Grants

  1. Cellular and Molecular Mechanisms Regulating Photoreceptor Morphology
    ABIGAIL M JENSEN; Fiscal Year: 2010
  2. Role of Protein Kinase C Iota in Colon Carcinogenesis
    Nicole Murray; Fiscal Year: 2006
  3. Apical Ezrin Assembly the Cytoskeleton and Diarrheal Disorders
    Pedro Salas; Fiscal Year: 2007
  4. Apical Ezrin Assembly the Cytoskeleton and Diarrheal Disorders
    PEDRO JI SALAS; Fiscal Year: 2010
  5. VTC Events Mediated by the Rab2 Complex
    Ellen J Tisdale; Fiscal Year: 2010
  6. Wwox and Fhit loss and the DNA damage response in breast cancer subtypes
    Kay Huebner; Fiscal Year: 2010
  7. Role of Protein Kinase C in Colon Carcinogenesis
    ALAN FIELDS; Fiscal Year: 2007
  8. Wwox as a Critical Signal Mediator in Breast Cancer
    Kay Huebner; Fiscal Year: 2007
  9. Fhit modulation of cell cycle progression and DNA damage response
    Kay Huebner; Fiscal Year: 2010
  10. Fhit modulation of cell cycle progression and DNA damage response
    Kay Huebner; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications123 found, 100 shown here

  1. ncbi Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
    K Conant
    Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    J Virol 70:1384-9. 1996
    ..These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor...
  2. ncbi aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6
    Hitoshi Ishiguro
    Department of Urology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Proc Natl Acad Sci U S A 106:16369-74. 2009
    ..Further, aPKClambda/iota expression might be a biomarker for prostate cancer progression...
  3. ncbi Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones
    Anastasia Mashukova
    Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Cell Sci 122:2491-503. 2009
    ..We conclude that both filamentous keratins and Hsp70 are required for the rescue rephosphorylation of mature atypical PKC, regulating the subcellular distribution and steady-state levels of active PKC iota...
  4. ncbi Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter
    W Clay Gustafson
    Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 279:9400-8. 2004
    ..Our results indicate that Bcr-Abl-mediated transformation involves transcriptional activation of the PKCiota gene, which in turn is required for Bcr-Abl-mediated chemoresistance...
  5. ncbi Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms
    Atsushi Suzuki
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 239 0004
    J Biochem 133:9-16. 2003
    ....
  6. ncbi Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells
    Flavia A Wald
    Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL 33135, USA
    J Cell Sci 121:644-54. 2008
    ....
  7. ncbi Correlation of aPKC-iota and E-cadherin expression with invasion and prognosis of cholangiocarcinoma
    Qiang Li
    Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Hepatobiliary Pancreat Dis Int 7:70-5. 2008
    ....
  8. ncbi HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta
    Yamina Bennasser
    Laboratoire d Immuno Virologie, EA 3038, Universite Paul Sabatier, 31062 Toulouse, France
    FASEB J 16:546-54. 2002
    ..Altogether, these results suggest that the induction of IL-10 by Tat is strictly dependent on the PKC-delta and -betaII isoforms...
  9. ncbi Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity
    Tomoyuki Yamanaka
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Japan
    Curr Biol 13:734-43. 2003
    ..However, how physically separated proteins interact remains to be clarified...
  10. ncbi Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62
    P Sanchez
    Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, Canto Blanco, Spain
    Mol Cell Biol 18:3069-80. 1998
    ..This is particularly relevant in light of the role played by the aPKCs in mitogenic cell signaling events...
  11. ncbi A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Cell Immunol 137:1-13. 1991
    ....
  12. ncbi The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors
    Yasuyuki Kojima
    Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Hum Pathol 39:824-31. 2008
    ..This is also the first evidence to show aPKC lambda/iota overexpression in breast cancer and demonstrates that its localization is associated with the trend of pathologic type of the tumor...
  13. ncbi Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C
    Y Noda
    Department of Molecular and Structural Biology, Kyushu University Graduate School of Medical Science, Fukuoka 812 8582, Japan
    Genes Cells 6:107-19. 2001
    ..However, little is known about a link between PAR proteins and the GTPases in cell polarization...
  14. ncbi Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures
    A Suzuki
    Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    J Cell Biol 152:1183-96. 2001
    ..These results indicate that aPKC is involved in the evolutionarily conserved PAR protein complex, and plays critical roles in the development of the junctional structures and apico-basal polarization of mammalian epithelial cells...
  15. ncbi HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system
    H Idriss
    Sealy Center for Molecular Science, The University of Texas Medical Branch Galveston, TX 77555 0851, USA
    Int J Biochem Cell Biol 31:1443-52. 1999
    ..Our results indicate that purified HIV-1 RT can be phosphorylated by several mammalian protein kinases in vitro and during expression in baculovirus infected insect cells...
  16. ncbi A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1
    A Balendran
    MRC Protein Phosphorylation Unit, Division of Signal Transduction Therapy, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 275:20806-13. 2000
    ..These findings indicate that the hydrophobic motif of PRK2 and PKCzeta acts as a "docking site" enabling the recruitment of PDK1 to these substrates. This is essential for their phosphorylation by PDK1 in cells...
  17. ncbi The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    G Joberty
    Markey Center for Cell Signaling, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908 0577, USA
    Nat Cell Biol 2:531-9. 2000
    ..This assembly is implicated in the formation of normal tight junctions at epithelial cell-cell contacts. Thus, Par6 is a key adaptor that links Cdc42 and atypical PKCs to Par3...
  18. ncbi HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes
    I W Park
    Division of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Blood 97:352-8. 2001
    ..These data indicate that the HIV-1 Tat protein may act as a protocytokine by causing the release of MCP-1 from the endothelial monolayer, and thereby facilitating monocyte transmigration into tissues via a PKC signaling pathway...
  19. ncbi Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway
    A Badou
    Laboratoire d Immuno Virologie EA3038, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    J Virol 74:10551-62. 2000
    ..This production of IL-10 induced by Tat could participate in the progression of HIV infection to AIDS...
  20. ncbi Regulation of glioblastoma cell invasion by PKC iota and RhoB
    R M Baldwin
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Oncogene 27:3587-95. 2008
    ..PKC iota and RhoB are, therefore, mutually antagonistic, potentially creating a sensitive switch between invasive and non-invasive phenotypes...
  21. ncbi Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium
    M B Huang
    Department of Biochemistry, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Acquir Immune Defic Syndr 25:375-89. 2000
    ....
  22. ncbi Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains
    Lijun Xu
    University of Florida Shands Cancer Center, Department of Medicine, University of Florida, Gainesville, 32610 0232, USA
    J Biol Chem 281:4457-66. 2006
    ..These findings reveal a novel role for PKCiota as a nicotine-activated, physiological calpain kinase that directly phosphorylates and activates calpains, leading to enhanced migration and invasion of human lung cancer cells...
  23. ncbi Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 144:3928-35. 1990
    ....
  24. ncbi Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C
    A Jakobovits
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    EMBO J 9:1165-70. 1990
    ..Our results indicate that PKC regulates the process of HIV-1 transactivation, suggesting a key role for the mitogenic induction of trans-activation in the transition of HIV from latency to productive growth...
  25. ncbi Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway
    Danny Ramzy
    Heart Transplant Program, University of Toronto, Toronto, Ontario, Canada
    Circulation 114:I319-26. 2006
    ..We assessed the effects of elevated ET-1 levels as seen after I/R to determine if ET-1 modulates nitric oxide (NO) production via the translocation of specific protein kinase C (PKC) isoforms...
  26. ncbi Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer
    Astrid M Eder
    Department of Molecular Therapeutics, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:12519-24. 2005
    ..These results implicate PKCiota as a potential oncogene in ovarian cancer regulating epithelial cell polarity and proliferation and suggest that PKCiota is a novel target for therapy...
  27. ncbi Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity
    Roderick P Regala
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 280:31109-15. 2005
    ..Our data indicate that PKCiota may be an attractive molecular target for mechanism-based therapies for treatment of lung cancer...
  28. ncbi Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase
    Zhaohui Jin
    University of Florida Shands Cancer Center, Department of Medicine, University of Florida, Gainesville, Florida 32610 0232, USA
    J Biol Chem 280:16045-52. 2005
    ....
  29. ncbi Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine 92717
    Int J Immunopharmacol 16:197-204. 1994
    ..The most striking change was observed in PKC-zeta isozymes levels. This study for the first time demonstrates that HIV-1 gp120 affects calcium-independent PKC isozymes in U937 cells...
  30. ncbi Protein kinase C iota: human oncogene, prognostic marker and therapeutic target
    Alan P Fields
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Pharmacol Res 55:487-97. 2007
    ..Throughout, we identify key unanswered questions and exciting future avenues of investigation regarding this important oncogenic molecule...
  31. ncbi In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46
    A M Holmes
    Biochemistry Department, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Arch Biochem Biophys 335:8-12. 1996
    ..Several Tat peptides, containing serine at position 46, are the only ones which are phosphorylated at significant rates. Several other Tat peptides containing potential protein kinase C phosphorylation sites are not phosphorylated...
  32. ncbi Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport
    Mini P Sajan
    James A Haley Veterans Medical Center and Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 281:17466-73. 2006
    ..These findings in knockdown and, more convincingly, rescue studies, strongly support the hypothesis that aPKCs are required for insulin-stimulated glucose transport in myocytes and adipocytes...
  33. ncbi Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo
    Nicole R Murray
    Mayo Clinic Comprehensive Cancer Center, Griffin Cancer Research Building, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    J Cell Biol 164:797-802. 2004
    ..Our data demonstrate that PKCiota is required for oncogenic Ras- and carcinogen-mediated colon carcinogenesis in vivo and define a procarcinogenic signaling axis consisting of Ras, PKCiota, and Rac1...
  34. ncbi The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
    M T Diaz-Meco
    Centro de Biología Molecular Consejo Superior de Investigaciones Cientificas Universidad Autónoma de Madrid
    Cell 86:777-86. 1996
    ..These findings support a role for the atypical PKC subspecies in the control of cell growth and survival...
  35. ncbi Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis
    L Jamieson
    Sealy Center for Oncology and Hematology, University of Texas Medical Branch, Galveston, Texas 77555 1048, USA
    J Biol Chem 274:3927-30. 1999
    ..Furthermore, they identify PKCiota as a critical downstream target of Bcr-Abl that is sufficient to mediate the anti-apoptotic effects of Bcr-Abl...
  36. ncbi Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells
    E Razin
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Biol Chem 274:34272-6. 1999
    ..We found protein kinase C-interacting protein 1 (PKCI) specifically associated with mi in yeast two-hybrid screening...
  37. ncbi The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation
    L Sanz
    Laboratorio Glaxo Wellcome CSIC de Biología Molecular y Celular, Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Spain
    EMBO J 18:3044-53. 1999
    ..Together, these results demonstrate that the interaction of p62 with RIP serves to link the atypical PKCs to the activation of NF-kappaB by the TNFalpha signaling pathway...
  38. ncbi Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis
    N R Murray
    Sealy Center for Oncology and Hematology and Department of Pharmacology, University of Texas Medical Branch, Galveston, Texas 77555 1048, USA
    J Biol Chem 272:27521-4. 1997
    ..PKC iota also protects K562 cells against taxol-induced apoptosis, indicating that it plays a general protective role against apoptotic stimuli. These data support a role for PKC iota in leukemia cell survival...
  39. ncbi The response of phospholipase C/protein kinase C and adenylyl cyclase/protein kinase A pathways in porcine theca interna cells to opioid agonist FK 33-824
    T Kaminski
    Department of Animal Physiology, University of Warmia and Mazury in Olsztyn, 10 719 Olsztyn Kortowo 1A, Poland
    Domest Anim Endocrinol 27:379-96. 2004
    ..Protein kinase C (PKC) inhibitors, staurosporine (1-100 nM), D-sphingosine (10-500 nM), and PKCi (100-2000 nM), both added alone and together with the opioid agonist, depressed release of the steroid hormones...
  40. ncbi Effect of protein kinase C inhibitor (PKCI) on radiation sensitivity and c-fos transcription
    E K Choi
    Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea
    Int J Radiat Oncol Biol Phys 49:397-405. 2001
    ..Here we have studied the effect of PKC inhibitor (PKCI) on radiation sensitivity and c-fos transcription in normal and AT cells, and also studied whether PKCI effect on c-..
  41. ncbi RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling
    Seena K Ajit
    Neuroscience Discovery, Wyeth Research CN 8000, Princeton NJ 08543, USA
    Cell Signal 19:723-30. 2007
    Protein kinase C interacting protein (PKCI-1) was identified among the potential interactors from a yeast two hybrid screen of human brain library using N terminal of RGSZ1 as a bait...
  42. ncbi Resveratrol attenuates adenosine diphosphate-induced platelet activation by reducing protein kinase C activity
    Yu Min Yang
    Department of CCU, The First Affiliated Hospital, Inner Mongolia Medical College, Hohhot, China
    Am J Chin Med 36:603-13. 2008
    ..Moreover, DL-erythro-1,3-Dihydroxy-2-aminooctadecane, an elective protein kinase C inhibitor (PKCI), and RESV had additive effects of inhibiting the percentage of platelet aggregation and surface P-selectin-..
  43. ncbi The involvement of protein kinases in signalling of opioid agonist FK 33-824 in porcine granulosa cells
    T Kaminski
    Department of Animal Physiology, Faculty of Biology, University of Warmia and Mazury in Olsztyn, Oczapowski Street 1A, Olsztyn Kortowo 10 719, Poland
    Anim Reprod Sci 91:107-22. 2006
    ..Protein kinase C (PKC) inhibitors - staurosporine (1-100 nM), d-sphingosine (10-500 nM) and PKCi (100-2000 nM) - both alone and in combination with FK 33-824 reduced E2 release from the cells in relation to the ..
  44. ncbi Modulation of ACh receptor currents by arachidonic acid
    T Nishizaki
    Department of Physiology, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Brain Res Mol Brain Res 57:173-9. 1998
    ..The potentiation was blocked by the selective protein kinase C (PKC) inhibitor, GF109203X or PKC inhibitor peptide (PKCI)...
  45. ncbi A molecular supermatrix of the rabbits and hares (Leporidae) allows for the identification of five intercontinental exchanges during the Miocene
    Conrad A Matthee
    Evolutionary Genomics Group, Department of Zoology, University of Stellenbosch, Stellenbosch, 7602, South Africa
    Syst Biol 53:433-47. 2004
    ..Five nuclear (SPTBN1, PRKCI, THY, TG, and MGF) and two mitochondrial (cytochrome b and 12S rRNA) gene fragments were analyzed singly and in ..
  46. ncbi Arachidonic acid potentiates currents through Ca2+-permeable AMPA receptors by interacting with a CaMKII pathway
    T Nishizaki
    Department of Physiology, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Brain Res Mol Brain Res 67:184-9. 1999
    ..inhibitor of cAMP-dependent protein kinase (PKA), H-89, the selective inhibitors of protein kinase C (PKC), PKCI and GF109203X, the mitogen-activated protein (MAP) kinase kinase inhibitor, PD98059, or the inactive CaMKII ..
  47. ncbi Arachidonic acid induces a long-lasting facilitation of hippocampal synaptic transmission by modulating PKC activity and nicotinic ACh receptors
    T Nishizaki
    Department of Physiology, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Brain Res Mol Brain Res 69:263-72. 1999
    ..Xenopus oocytes, and the effect was blocked by the selective protein kinase C (PKC) inhibitors, such as GF109203X, PKCI, and co-expressed active PKC inhibitor peptide...
  48. ncbi High glucose decreases collagenase expression and increases TIMP expression in cultured human peritoneal mesothelial cells
    Jin Ju Kim
    Yonsei University College of Medicine, Department of Internal Medicine, 134 Shinchon Dong Seodaemoon Gu, Seoul, Korea, 120 752
    Nephrol Dial Transplant 23:534-41. 2008
    ..This study was undertaken to elucidate the effects of high glucose on these proteolytic processes in cultured HMPCs...
  49. ncbi Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family
    M G Klein
    Herbert Irving Comprehensive Cancer Center, Room 1509, 701 West 168th Street, New York, New York, 10032, USA
    Exp Cell Res 244:26-32. 1998
    ..This led to the isolation of a murine PKCI homologue (mPKCI)...
  50. ncbi Suppression of progression and metastasis of established colon tumors in mice by intravenous delivery of short interfering RNA targeting KITENIN, a metastasis-enhancing protein
    Ji Hee Lee
    Medical Research Center for Gene Regulation, Chonnam National University Medical School, Kwangju, South Korea
    Cancer Res 65:8993-9003. 2005
    ..mediators of these actions: 90K protein, a known immune modulatory glycoprotein, and protein kinase C inhibitor (PKCI). 90K was increased in the culture medium from CT-26/antisense KITENIN/90K cells...
  51. ncbi Age- and sex-related differences in contrast sensitivity in C57BL/6 mice
    Bart van Alphen
    Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 50:2451-8. 2009
    ..In addition, the authors tested a mutant in which plasticity in the cerebellum is impaired by expressing a protein kinase C inhibitor. This inhibitor is also expressed in the retina, possibly affecting vision...
  52. ncbi Novel immunohistochemical markers for the differentiation of lobular and ductal invasive breast carcinomas
    Gulisa Turashvili
    Laboratory of Molecular Pathology, Department of Pathology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 151:59-64. 2007
    ..The aim of our study was to identify the diagnostic usefulness of novel markers in the differentiation of these tumor types...
  53. ncbi [Neomycin inhibits nicotinic receptor-mediated response in pheochromocytoma (PC12) cells]
    Li jun Shi
    Department of Physiology, Beijing Medical College of PLA, Beijing, China
    Sheng Li Xue Bao 54:441-5. 2002
    ..However, intracellular dialysis with a PKC inhibitor (PKCI 19-31, 0.1~5 micromol/L) did not affect the inhibitory effect of neomycin...
  54. ncbi Utility of nuclear DNA intron markers at lower taxonomic levels: phylogenetic resolution among nine Tragelaphus spp
    Sandi Willows-Munro
    Evolutionary Genomics Group, Department of Zoology, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa
    Mol Phylogenet Evol 35:624-36. 2005
    ..and to provide additional data pertinent to tragelaphid evolution, we sequenced four nuclear DNA segments (MGF, PRKCI, SPTBN, and THY) and combined these data with mitochondrial DNA sequences from three genes (cytochrome b, 12S rRNA,..
  55. ncbi [mRNA expression of genes related to avian sex determination during female-to-male sex reversal in ZW chicken embryos]
    Jiang Xia Zheng
    College of Animal Science and Technology, China Agricultural University, Beijing, China
    Yi Chuan 29:81-6. 2007
    ..This finding might account for the specific effect of PKCIW, functioning via heterodimerization with PKCI during avian sex determination...
  56. ncbi Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins
    Raphael Lemaire
    Boston University School of Medicine, The Arthritis Center, Boston, Massachusetts 02118, USA
    Genes Dev 16:594-607. 2002
    ..The isolated cDNA, referred to here as PKCI-r (for PKCI-related), is closely related to the protein kinase C interacting protein (PKCI-1) gene...
  57. ncbi Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins
    C D Lima
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 93:5357-62. 1996
    The three-dimensional structure of protein kinase C interacting protein 1 (PKCI-1) has been solved to high resolution by x-ray crystallography using single isomorphous replacement with anomalous scattering...
  58. ncbi Supersensitivity to amphetamine in protein kinase-C interacting protein/HINT1 knockout mice
    Elisabeth Barbier
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Neuropsychopharmacology 32:1774-82. 2007
    Protein kinase C interacting protein/histidine triad nucleotide binding protein 1 (PKCI/HINT1) is a member of the histidine triad protein family...
  59. ncbi Wpkci, encoding an altered form of PKCI, is conserved widely on the avian W chromosome and expressed in early female embryos: implication of its role in female sex determination
    T Hori
    Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555 Japan
    Mol Biol Cell 11:3645-60. 2000
    ..clones were demonstrated to be derived from the mRNA encoding an altered form of PKC inhibitor/interacting protein (PKCI), and its gene was named Wpkci...
  60. ncbi NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors
    María Rodríguez-Muñoz
    Department of Molecular, Cellular and Developmental Neurobiology, Cajal Institute, Madrid, Spain
    Cell Signal 20:1855-64. 2008
    ..receptor (MOR) binds to the protein kinase C-interacting protein/histidine triad nucleotide binding protein 1 (PKCI/HINT1) which in turn binds the regulator of G-protein signalling RGSZ1/Z2 (RGSZ) protein...
  61. ncbi Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone level
    Elisabeth Barbier
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, Baltimore, Maryland 21201, USA
    BMC Neurosci 10:132. 2009
    Protein kinase C interacting protein (PKCI/HINT1) is a small protein belonging to the histidine triad (HIT) family proteins. Its brain immunoreactivity is located in neurons and neuronal processes...
  62. ncbi Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis
    Roderick P Regala
    Departments of Cancer Biology and Pathology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida, USA
    Cancer Res 69:7603-11. 2009
    ..by Cre-mediated recombination in the lung with or without simultaneous genetic loss of the mouse PKCiota gene, Prkci. Genetic loss of Prkci dramatically inhibits Kras-initiated hyperplasia and subsequent lung tumor formation in ..
  63. ncbi Aberrant gene expression in human non small cell lung carcinoma cells exposed to demethylating agent 5-aza-2'-deoxycytidine
    Bao Zhu Yuan
    Laboratory of Cancer Genetics, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neoplasia 6:412-9. 2004
    ..of tyrosine protein kinase ABL2 (ABL2) gene and upregulation of hint/protein kinase C inhibitor 1 (Hint/PKCI-1), DVL1, TIMP-1, and TRP-1 genes were found in expanded observations in two or three of five 5-aza-dC-treated ..
  64. ncbi Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1)
    P M Brzoska
    Department of Radiation Oncology, University of California, San Francisco, California, 94143, USA
    Genomics 36:151-6. 1996
    ..cDNA sequence, genomic mapping, and immunolocalization of the first human member of the protein kinase C inhibitor (PKCI-1) gene family...
  65. ncbi Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome
    Tobias B Huber
    Renal Division, University Hospital Freiburg, Breisacher Strasse 66, D 79106 Freiburg, Germany
    J Am Soc Nephrol 20:798-806. 2009
    ..These results suggest that aPKC signaling is fundamental to glomerular maintenance and development...
  66. ncbi Apical polarity protein PrkCi is necessary for maintenance of spinal cord precursors in zebrafish
    Randolph K Roberts
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA
    Dev Dyn 238:1638-48. 2009
    ..of zebrafish spinal cord precursors using time-lapse imaging and tested the function of protein kinase C, iota (PrkCi), a member of the Par complex of proteins necessary for apicobasal polarity in the nervous system...
  67. ncbi Attenuation of renal ischemia-reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation
    Shady M Eldaif
    Division of Cardiothoracic Surgery, Department of Surgery, Emory University School of Medicine and Carlyle Fraser Heart Center Cardiothoracic Research Laboratory, Emory Crawford Long Hospital, Atlanta, GA 30308 2225, USA
    Transpl Int 23:217-26. 2010
    ..4) PoC + ARi: PoC plus the AR antagonist 8-rho-(sulfophenyl) theophylline (8-SPT). (5) PoC + PKCi: PoC plus the PKC antagonist chelerythrine (Che)...
  68. ncbi Oculomotor plasticity during vestibular compensation does not depend on cerebellar LTD
    M Faulstich
    Systems Neurobiology Laboratory, Salk Institute, La Jolla, CA, USA
    J Neurophysiol 96:1187-95. 2006
    ..which LTD is specifically blocked in Purkinje cells via expression of a peptide inhibitor of protein kinase C (L7-PKCi mutants)...
  69. ncbi Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?
    Eric Burguiere
    Laboratoire de Physiologie de la Perception et de l Action, UMR CNRS 7152, 11 place Marcelin Berthelot, College de France, 75005 Paris, France
    Nat Neurosci 8:1292-4. 2005
    L7-PKCI transgenic mice, which lack parallel fiber-Purkinje cell long-term depression (LTD), were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation...
  70. ncbi Role of the cerebellar cortex in conditioned goal-directed behavior
    Eric Burguiere
    Navigation, Memory and Aging team, UMR CNRS 7102, Universite Pierre et Marie Curie, F 75005, Paris, France
    J Neurosci 30:13265-71. 2010
    ..The mouse mutants L7-PKCi, which suffer from impaired PKC-dependent processes such as parallel fiber to Purkinje cell long-term depression (..
  71. ncbi High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors
    Peter M Haverty
    Department of Bioinformatics, Genentech, Inc, South San Francisco, CA, USA
    BMC Med Genomics 2:21. 2009
    ..Likewise, the cell polarity regulators PRKCI and ECT2 were identified as putative drivers of two distinct amplicons on 3q...
  72. ncbi MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family
    C D Lima
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Structure 5:763-74. 1997
    ..The structural analysis of FHIT will identify critical residues involved in substrate binding and catalysis, and will provide insights into the in vivo function of HIT proteins...
  73. ncbi Numb controls E-cadherin endocytosis through p120 catenin with aPKC
    Kazuhide Sato
    Department of Cell Pharmacology, Nagoya University Graduate School of Medicine, Showa, Nagoya, Aichi 466 8550, Japan
    Mol Biol Cell 22:3103-19. 2011
    ..Thus, we propose that aPKC phosphorylates Numb to prevent its binding to p120 and ?-adaptin, thereby attenuating E-cadherin endocytosis to maintain apicobasal polarity...
  74. ncbi KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells
    Yohei Yoshihama
    Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Curr Biol 21:705-11. 2011
    ..These results strongly support the notion that KIBRA regulates epithelial cell polarity by suppressing apical exocytosis through direct inhibition of aPKC kinase activity in the PAR3-aPKC-PAR6 complex...
  75. ncbi PKCzetaII is a target for degradation through the tumour suppressor protein pVHL
    Xavier Iturrioz
    Protein Phosphorylation Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields Laboratories, London WC2A 3PX, UK
    FEBS Lett 581:1397-402. 2007
    ..The results indicate that pVHL recruits PKCzetaII via its PB1 domain and causes ubiquitination and degradation via the distal C-terminus of PKCzetaII...
  76. ncbi Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity
    Björn Hartleben
    Renal Division, University Hospital Freiburg, D 79106 Freiburg, Germany
    J Biol Chem 283:23033-8. 2008
    ....
  77. ncbi [Expression and significance of aPKC-iota and E-cadherin in cholangiocarcinoma]
    Qiang Li
    Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P R China
    Ai Zheng 26:715-8. 2007
    ..This study was to investigate the expression of aPKC-iota and E-cadherin in cholangiocarcinoma, and analyze molecular mechanisms of the invasion and metastasis of cholangiocarcinoma...
  78. ncbi NF-kappaB functions in the nervous system: from development to disease
    Sylvie Memet
    Unité de Mycologie Moléculaire, FRE CNRS 2849, Department of Infection and Epidemiology, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Biochem Pharmacol 72:1180-95. 2006
    ..g. neurons and glia. Current knowledge of the contribution of NF-kappaB to several neurodegenerative disorders, such as Alzheimer's, Parkinson's and Huntington's diseases is also summarized...
  79. ncbi Atypical protein kinase C regulates primary dendrite specification of cerebellar Purkinje cells by localizing Golgi apparatus
    Koji Tanabe
    Laboratory for Vertebrate Axis Formation, RIKEN Center for Developmental Biology, Kobe, Hyogo 650 0047, Japan
    J Neurosci 30:16983-92. 2010
    ..We also demonstrated that in a mutant of an atypical protein kinase C (aPKC), Prkci, Purkinje cells retain multiple primary dendrites and show disrupted localization of the Golgi apparatus...
  80. ncbi Involvement of PKC-iota in glioma proliferation
    R Patel
    Department of Chemistry, University of South Florida, and James A Haley Veterans Hospital, Tampa, FL 33612, USA
    Cell Prolif 41:122-35. 2008
    ..However, in vivo, the status and function of PKC-iota in human normal brain tissue, gliomas, benign and malignant meningiomas as well as its in vitro status in proliferating and confluent glioma cells, remains unknown...
  81. ncbi Distribution and expression of protein kinase C interactive protein (PKCI/HINT1) in mouse central nervous system (CNS)
    Qing Liu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Neurochem Res 33:1263-76. 2008
    Protein kinase C interactive protein (PKCI; also known as histidine triad protein, HINT1) is a small intracellular protein widely expressed in tissues from both the peripheral and CNS...
  82. ncbi Survey of the effect of genetic variations on gene expression in human prefrontal cortex and its application to genetics of psychiatric disorders
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Neurosci Res 70:238-42. 2011
    ..We found that SNPs in the AKAP10 and PRKCI genes are significantly associated with bipolar disorder and gene expression variation.
  83. ncbi Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis
    Stefan Rohr
    Max Delbrück Center MDC Strasse 10, 13125 Berlin, Germany
    Development 133:107-15. 2006
    ..Here, we show that zebrafish heart and soul (Has)/protein kinase C iota (PRKCi) is required tissue-autonomously within the myocardium for normal heart morphogenesis and that this function ..
  84. ncbi [HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway]
    Y Bennasser
    Laboratoire d Immuno Virologie, Université Paul Sabatier 118, route de Narbonne, 31062 Toulouse
    J Soc Biol 195:319-26. 2001
    ..Using microspectrofluorimetry and confocal microscopy, we also show that Tat induces a calcium influx...
  85. ncbi Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells
    P Borgatti
    Division of Signal Transduction, Harvard Institute of Medicine, Beth Israel Hospital, Boston, Massachusettes 02115, USA
    Biochem Biophys Res Commun 242:332-7. 1998
    ..Taken together, these findings demonstrate that extracellular Tat shows a cytokine-like activity in PC12 cells, being able to trigger an intracellular signalling cascade which involves PKC-alpha, -epsilon, and -zeta...
  86. ncbi Decrease in acetylcholine-induced current by neomycin in PC12 cells
    Li jun Shi
    Department of Physiology, Beijing Medical College of PLA, Beijing 100071, China
    Arch Biochem Biophys 403:35-40. 2002
    ..C activation by using an exogenous activator produced inhibition of I(ACh), while using protein kinase C inhibitor (PKCI 19-31) had no effect on the inhibition of I(ACh) induced by neomycin...
  87. ncbi PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions
    Motoyuki Kohjima
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 299:641-6. 2002
    ..Nevertheless PAR3beta, expressed intrinsically or extrinsically, localizes to the tight junctions, indicating that the localization does not require the ternary complex formation...
  88. ncbi Regulation of cell survival by atypical protein kinase C isozymes
    Hans H Grunicke
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz pregel Str 3, A-6020, Innsbruck, Austria
    Adv Enzyme Regul 43:213-28. 2003
  89. ncbi Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis
    Tao Su
    Herbert Irving Comprehensive Cancer Center and Integrated Program in Cellular, Molecular, and Biophysical Studies, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:7824-9. 2003
    PKC-interacting protein (PKCI), also designated histidine triad nucleotide-binding protein 1, belongs to the histidine triad (HIT) family of proteins...
  90. ncbi Structure-based analysis of catalysis and substrate definition in the HIT protein family
    C D Lima
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Science 278:286-90. 1997
    ..Fragile histidine triad protein (FHIT) and protein kinase C interacting protein (PKCI) were used in a structure-based approach to elucidate characteristics of in vivo ligands and reactions...
  91. ncbi Carbachol induces inward current in rat neostriatal neurons through a G-protein-coupled mechanism
    K S Hsu
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, ROC
    Neurosci Lett 224:79-82. 1997
    ..not affected by intracellular dialysis of the neostriatal neurons with either protein kinase C (PKC) inhibitors, PKCI 19-36 (5 microM) or NPC-15437 (20 microM), or a potent cAMP-dependent protein kinase (PKA) inhibitor, Rp-cAMPS (25 ..
  92. ncbi Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins
    N Korsisaari
    Haartman Institute and Biocentrum Helsinki, P O Box 21, University of Helsinki, 00014 Helsinki, Finland
    J Biol Chem 275:34837-40. 2000
    ..Here, we report a novel interaction between Cdk7 and a histidine triad (HIT) family protein, Hint/PKCI-1...
  93. ncbi Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C
    L Varticovski
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111
    Biochemistry 27:3682-90. 1988
    ..These sites are compared to the phosphorylation sites previously located in the structurally related protein lipocortin II...
  94. ncbi Human immunodeficiency virus induces phosphorylation of its cell surface receptor
    A P Fields
    Johns Hopkins Oncology Center, Baltimore, Maryland 21231
    Nature 333:278-80. 1988
    ..These results indicate a possible role for HIV-induced CD4 phosphorylation in viral entry and identify a potential target for antiviral therapy...
  95. ncbi HIT family genes: FHIT but not PKCI-1/HINT produces altered transcripts in colorectal cancer
    J Elnatan
    Molecular Biology Laboratory, Tan Tock Seng Hospital, Singapore, Republic of Singapore
    Br J Cancer 81:874-80. 1999
    Forty-five colorectal adenocarcinomas were examined for alterations in the HIT family genes FHIT and PKCI-1/HINT by a combination of reverse transcriptase polymerase chain reaction and DNA sequencing...
  96. ncbi Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C
    Eva Zemlickova
    University of Edinburgh, School of Biomedical and Clinical Laboratory Sciences, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Biochem Biophys Res Commun 307:459-65. 2003
    ..Centaurin-alpha(1) is also a substrate for all PKC classes and we have identified the two sites of phosphorylation. This is the first report of a kinase that phosphorylates centaurin-alpha(1)...
  97. ncbi Role of protein kinase C-iota in transformed non-malignant RWPE-1 cells and androgen-independent prostate carcinoma DU-145 cells
    H Y Win
    Department of Chemistry, University of South Florida, Tampa, Florida, USA
    Cell Prolif 42:182-94. 2009
    ..Objective: In this study, we investigated the role of atypical protein kinase C-iota (PKC-iota) in androgen independent prostate DU-145 carcinoma cellscompared to transformed non-malignant prostate RWPE-1 cells...
  98. ncbi Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates
    J Tozser
    Department of Biochemistry and Molecular Biology, University Medical School of Debrecen, Hungary
    Eur J Biochem 265:423-9. 1999
    ....
  99. ncbi Protein kinase C isoforms in human erythrocytes
    R B Govekar
    Biochemistry and Molecular Biology Division, Cancer Research Institute, Tata Memorial Centre, Parel, Mumbai, India
    Ann Hematol 80:531-4. 2001
    ....
  100. ncbi Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling
    Y P Lim
    Signal Transduction Laboratory, Institute of Molecular and Cell Biology, National University of Singapore, 30 Medical Drive, Singapore 117609, Republic of Singapore
    J Biol Chem 274:19025-34. 1999
    ..It is likely that FRS2 serves as an anchoring protein for targeting activated atypical PKCs to the cell plasma membrane in signaling pathways...
  101. ncbi The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC
    L Ren
    Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Oncogene 28:792-802. 2009
    ..These data are the first to suggest a dynamic regulation of ezrin phosphorylation during metastasis and to connect the PKC family members with this regulation...

Research Grants62

  1. Cellular and Molecular Mechanisms Regulating Photoreceptor Morphology
    ABIGAIL M JENSEN; Fiscal Year: 2010
    ..2) Examine the role of Prkci in regulating Crumbs protein function and photoreceptor and Muller glial morphology...
  2. Role of Protein Kinase C Iota in Colon Carcinogenesis
    Nicole Murray; Fiscal Year: 2006
    ..Several lines of evidence suggest that the atypical PKC iota isoform (PKCi) plays an important promotive role in colon carcinogenesis...
  3. Apical Ezrin Assembly the Cytoskeleton and Diarrheal Disorders
    Pedro Salas; Fiscal Year: 2007
    ..apical localization of ezrin in intestinal cells and provides a microdomain-restricted site for its activation by PKCi. The assembly of this ezrin-based scaffold is essential for the function of the effectors of secretory diarrheas (..
  4. Apical Ezrin Assembly the Cytoskeleton and Diarrheal Disorders
    PEDRO JI SALAS; Fiscal Year: 2010
    ..apical localization of ezrin in intestinal cells and provides a microdomain-restricted site for its activation by PKCi. The assembly of this ezrin-based scaffold is essential for the function of the effectors of secretory diarrheas (..
  5. VTC Events Mediated by the Rab2 Complex
    Ellen J Tisdale; Fiscal Year: 2010
    ..Rab2- mediated vesicle formation requires atypical PKCi/X and GAPDH...
  6. Wwox and Fhit loss and the DNA damage response in breast cancer subtypes
    Kay Huebner; Fiscal Year: 2010
    ..Chemotherapy is currently the only option for these cancers and might become a better option if targeted inhibition of DNA repair pathways were combined with DNA damaging agents, such as carboplatin. ..
  7. Role of Protein Kinase C in Colon Carcinogenesis
    ALAN FIELDS; Fiscal Year: 2007
    ..PKCbetaII also induces an invasive phenotype in RIE cells through activation of a PKCbetaII->Ras/Mek->PKCI/Rac1 signaling pathway...
  8. Wwox as a Critical Signal Mediator in Breast Cancer
    Kay Huebner; Fiscal Year: 2007
    ..4. Map the extent of WWOX promoter methylation throughout surgically removed cancerous breast tissues. This aim will determine if WWOX silencing is a marker of a field cancerization effect. ..
  9. Fhit modulation of cell cycle progression and DNA damage response
    Kay Huebner; Fiscal Year: 2010
    ..cycle, DDR and apoptosis associated proteins in early oral and upper gastrointestinal tract lesions of Fhit-deficient mice before and after FHIT replacement by AdenoFHIT oral gene therapy. , ..
  10. Fhit modulation of cell cycle progression and DNA damage response
    Kay Huebner; Fiscal Year: 2007
    ..cycle, DDR and apoptosis associated proteins in early oral and upper gastrointestinal tract lesions of Fhit-deficient mice before and after FHIT replacement by AdenoFHIT oral gene therapy. , ..
  11. Protein Kinase C Signaling Mechanisms in Cancer
    Alan P Fields; Fiscal Year: 2010
    ..This project will elucidate the PKC? signaling mechanisms that drive lung cancer growth and assess the importance of PKC? signaling in lung cancer development, progression and spread in pre-clinical animal models in vivo. ..
  12. Wwox and Fhit loss and the DNA damage response in breast cancer subtypes
    Kay Huebner; Fiscal Year: 2009
    ..Chemotherapy is currently the only option for these cancers and might become a better option if targeted inhibition of DNA repair pathways were combined with DNA damaging agents, such as carboplatin. ..
  13. Fhit modulation of cell cycle progression and DNA damage response
    Kay Huebner; Fiscal Year: 2009
    ..cycle, DDR and apoptosis associated proteins in early oral and upper gastrointestinal tract lesions of Fhit-deficient mice before and after FHIT replacement by AdenoFHIT oral gene therapy. , ..
  14. PROTEIN KINASE C ISOTYPES IN LEUKEMIA CELL PHYSIOLOGY
    ALAN FIELDS; Fiscal Year: 1999
    ..Our results may uncover novel targets for therapeutic intervention in this disease and are likely to be relevant to the biology of many cancers. ..
  15. PROTEIN KINASE C AND COLON CARCINOGENESIS
    ALAN FIELDS; Fiscal Year: 2003
    ..These studies will allow the first direct analysis of the role of PKC betaII in colon cancer in two relevant animal models of the human disease. ..
  16. PROTEIN KINASE C ISOTYPES IN LEUKEMIA CELL PHYSIOLOGY
    ALAN FIELDS; Fiscal Year: 2002
    ....