PLA2G10

Summary

Gene Symbol: PLA2G10
Description: phospholipase A2, group X
Alias: GXPLA2, GXSPLA2, SPLA2, GX sPLA2, group 10 secretory phospholipase A2, group X secretory phospholipase A2, phosphatidylcholine 2-acylhydrolase 10, sPLA2-X
Species: human

Top Publications

  1. ncbi Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2
    L Cupillard
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, Sophia Antipolis, 660 route des Lucioles, 06560 Valbonne, France
    J Biol Chem 272:15745-52. 1997
  2. ncbi Potent modification of low density lipoprotein by group X secretory phospholipase A2 is linked to macrophage foam cell formation
    Kohji Hanasaki
    Shionogi Research Laboratories, Shionogi and Co, Ltd, Sagisu 5 12 4, Fukushima ku, Osaka 553 0002, Japan
    J Biol Chem 277:29116-24. 2002
  3. ncbi Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology
    Danielle M J Curfs
    Departments of Molecular Genetics and Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Universiteitssingel 50, Maastricht, The Netherlands
    J Biol Chem 283:21640-8. 2008
  4. ncbi Neuronal expression and neuritogenic action of group X secreted phospholipase A2
    Seiko Masuda
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Shinagawa ku, Tokyo, USA
    J Biol Chem 280:23203-14. 2005
  5. ncbi The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2
    Sarah Gora
    INSERM U525, Universite Pierre et Marie Curie Paris 6, Faculte de Medecine Pierre et Marie Curie, Paris, France
    Biochim Biophys Acta 1761:1093-9. 2006
  6. ncbi Atherogenic properties of LDL particles modified by human group X secreted phospholipase A2 on human endothelial cell function
    Sonia Athina Karabina
    INSERM UMRS 525, Faculte de Medecine Pierre et Marie Curie, 91, Boulevard de l Hopital, 75634 Paris, France
    FASEB J 20:2547-9. 2006
  7. ncbi Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation
    C Ruth Wooton-Kee
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky 40536 0084, USA
    Arterioscler Thromb Vasc Biol 24:762-7. 2004
  8. ncbi Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase A2
    Jae Ouk Kim
    Vaccine Research Center, NIAID, National Institutes of Health, Room 4502, Bldg 40, MSC 3005, 40 Convent Dr, Bethesda, MD 20892 3005, USA
    J Virol 81:1444-50. 2007
  9. ncbi Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI
    D W Snyder
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 288:1117-24. 1999
  10. ncbi Signal transduction in esophageal and LES circular muscle contraction
    K M Harnett
    Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
    Yale J Biol Med 72:153-68. 1999

Research Grants

  1. Amyloid Induced Proinflam. Pathways /Cerebrovasculature
    Michael Mullan; Fiscal Year: 2003
  2. Biochemical Studies of 14-kDa Phospholipases A2
    Michael Gelb; Fiscal Year: 2007
  3. Secretory Phospholipase A2s in Airway Pathophysiology
    Teal S Hallstrand; Fiscal Year: 2010
  4. Aging Stratum Corneum pH and Barrier Function
    Theodora M Mauro; Fiscal Year: 2010
  5. PROTEASE INHIBITOR RELATED DYSLIPIDEMIA
    Christine Wanke; Fiscal Year: 2009
  6. Stratum Corneum Acidification in the Neonate
    Kenneth Feingold; Fiscal Year: 2007
  7. Group V sPla2 in Inflammation and Innate Immunity
    Barbara Balestrieri; Fiscal Year: 2007
  8. PROTEASE INHIBITOR RELATED DYSLIPIDEMIA
    Christine Wanke; Fiscal Year: 2007
  9. PROTEASE INHIBITOR RELATED DYSLIPIDEMIA
    Christine A Wanke; Fiscal Year: 2010
  10. Novel Direct Approaches Toward Bioactive Heterocycles
    Vladimir Gevorgyan; Fiscal Year: 2010

Detail Information

Publications138 found, 100 shown here

  1. ncbi Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2
    L Cupillard
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, Sophia Antipolis, 660 route des Lucioles, 06560 Valbonne, France
    J Biol Chem 272:15745-52. 1997
    ..In this report, a cDNA coding for a novel sPLA2 has been isolated from human fetal lung, and its gene has been mapped to chromosome 16p13.1-p12...
  2. ncbi Potent modification of low density lipoprotein by group X secretory phospholipase A2 is linked to macrophage foam cell formation
    Kohji Hanasaki
    Shionogi Research Laboratories, Shionogi and Co, Ltd, Sagisu 5 12 4, Fukushima ku, Osaka 553 0002, Japan
    J Biol Chem 277:29116-24. 2002
    ..We demonstrate here that group X secretory phospholipase A2 (sPLA2-X) may be involved in this process...
  3. ncbi Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology
    Danielle M J Curfs
    Departments of Molecular Genetics and Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Universiteitssingel 50, Maastricht, The Netherlands
    J Biol Chem 283:21640-8. 2008
    ..Interestingly, enhanced sPLA(2)-X activity in macrophages in vivo leads to fatal pulmonary defects, suggesting a crucial role for sPLA(2)-X in inflammatory lung disease...
  4. ncbi Neuronal expression and neuritogenic action of group X secreted phospholipase A2
    Seiko Masuda
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Shinagawa ku, Tokyo, USA
    J Biol Chem 280:23203-14. 2005
    ..These observations suggest the potential contribution of sPLA(2)-X to neuronal differentiation, and possibly repair, under certain conditions...
  5. ncbi The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2
    Sarah Gora
    INSERM U525, Universite Pierre et Marie Curie Paris 6, Faculte de Medecine Pierre et Marie Curie, Paris, France
    Biochim Biophys Acta 1761:1093-9. 2006
    ..In conclusion, our study shows that hGX sPLA(2) may be a novel player in PAF regulation during inflammatory processes...
  6. ncbi Atherogenic properties of LDL particles modified by human group X secreted phospholipase A2 on human endothelial cell function
    Sonia Athina Karabina
    INSERM UMRS 525, Faculte de Medecine Pierre et Marie Curie, 91, Boulevard de l Hopital, 75634 Paris, France
    FASEB J 20:2547-9. 2006
    ..Our study examined the presence of hGX sPLA2 in human atherosclerotic lesions and investigated the ability of hGX modified LDL to alter human endothelial cell (..
  7. ncbi Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation
    C Ruth Wooton-Kee
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky 40536 0084, USA
    Arterioscler Thromb Vasc Biol 24:762-7. 2004
    Secretory phospholipase A2 (sPLA2) enzymes hydrolyze the sn-2 fatty acyl ester bond of phospholipids to produce a free fatty acid and a lysophospholid...
  8. ncbi Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase A2
    Jae Ouk Kim
    Vaccine Research Center, NIAID, National Institutes of Health, Room 4502, Bldg 40, MSC 3005, 40 Convent Dr, Bethesda, MD 20892 3005, USA
    J Virol 81:1444-50. 2007
    ..A specific secretory PLA2, sPLA2-X, is shown here to neutralize human immunodeficiency virus type 1 (HIV-1) through degradation of the viral ..
  9. ncbi Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI
    D W Snyder
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 288:1117-24. 1999
    LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, LY315920 inhibited sPLA2 activity with an IC50 of 9 +/- 1 nM or 7...
  10. ncbi Signal transduction in esophageal and LES circular muscle contraction
    K M Harnett
    Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
    Yale J Biol Med 72:153-68. 1999
    ..activity of a low molecular weight (approximately 14 kDa) pancreatic-like (group 1) secreted phospholipase A2 (sPLA2) and production of arachidonic acid (AA), which is metabolized to prostaglandins and thromboxanes...
  11. ncbi Alterations of concentrations of calcium and arachidonic acid and agglutinations of microfilaments in host cells during Toxoplasma gondii invasion
    Liwei Li
    Department of Medical Microbiology and Parasitology, Medical School of Zhejiang University, Hangzhou, 310058, China
    Vet Parasitol 157:21-33. 2008
    ..Elevated [Ca2+]i induced reorganization of host cell microfilaments. The invasion also activated secretory PLA2 (sPLA2) and cytosolic PLA2 (cPLA2) of the parasite to release AA, which increased the permeability of cell membrane.
  12. ncbi Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases
    Vanessa Moreira
    Laboratorio de Farmacologia, Instituto Butantan, Sao Paulo, Brazil
    Toxicon 52:428-39. 2008
    The effects of myotoxin III (MT-III), a phospholipase A(2) (sPLA2) from Bothrops asper snake venom, and crotoxin B (CB), a neurotoxic and myotoxic sPLA2 from the venom of Crotalus durissus terrificus, on cyclooxygenases (COXs) expression ..
  13. ncbi Human secretory phospholipase A2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice
    Uwe J F Tietge
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Arterioscler Thromb Vasc Biol 22:1213-8. 2002
    ..Secretory phospholipase A2 (sPLA2), an acute-phase protein, may play a key role in the pathophysiology of this phenomenon.
  14. ncbi Secretory low-molecular-weight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: factors of chronic proliferative cholangitis
    J Shoda
    Department of Gastroenterology, Institute of Clinical Medicine, The University of Tsukuba, Ibaraki, Japan
    Hepatology 29:1026-36. 1999
    ..phospholipases A2 (sPLA2s) as inflammatory mediators or factors modulating cell functions via their specific sPLA2-receptor, and also on the production and secretion of altered mucin molecules from the inflamed bile ducts...
  15. ncbi Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2)
    Rao S Koduri
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 277:5849-57. 2002
    Group IIA secreted phospholipase A(2) (sPLA2) is known to display potent Gram-positive bactericidal activity in vitro and in vivo...
  16. ncbi Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2
    E C Landucci
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil
    Toxicon 38:199-208. 2000
    ..complexed with phospholipase A2) and heparin on rat paw edema induced by different secretory phospholipases A2 (sPLA2) have been investigated...
  17. ncbi Biochemistry and physiology of mammalian secreted phospholipases A2
    Gerard Lambeau
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Universite de Nice Sophia Antipolis, 06560 Valbonne, France
    Annu Rev Biochem 77:495-520. 2008
    ..The mammalian genome contains 10 enzymatically active secreted PLA2s (sPLA2s) and two sPLA2-related proteins devoid of lipolytic enzymatic activity...
  18. ncbi CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792 3232, USA
    J Biol Chem 281:6718-25. 2006
    ..Transient middle cerebral artery occlusion (tMCAO) significantly increased PLA2 activity, secretory PLA2 (sPLA2)-IIA mRNA and protein levels, PtdCho-PLC activity, and PLD2 protein expression following reperfusion...
  19. ncbi Honeybee venom secretory phospholipase A2 induces leukotriene production but not histamine release from human basophils
    F B Mustafa
    Inflammation and Cancer Laboratory, Department of Physiology and NUS Immunology Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Clin Exp Immunol 151:94-100. 2008
    ..We wished to examine if secretory phospholipase A2, a systemic allergen found in honey bee venom (HBV-sPLA2) may activate basophils directly leading to rapid systemic mediator release...
  20. ncbi Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom
    D O Toyama
    Centro de Cidncias Biológicas e da Saúde, Univesidade Mackenzie, Sao Paulo, Brazil
    Toxicon 53:417-26. 2009
    ..their controlling effect on serine proteases is well acknowledged, their action on secretory phospholipase A2 (sPLA2) remains obscure...
  21. ncbi NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    J Wehkamp
    Department of Internal Medicine I, Robert Bosch Hospital, Stuttgart, Germany
    Gut 53:1658-64. 2004
    ..Paneth cells also express NOD2. To address the hypothesis that the function of NOD2 may affect expression of Paneth cell defensins, we compared their expression levels with respect to NOD2 mutations in Crohn's disease...
  22. ncbi Crucial role of group IIA phospholipase A2 in pancreatitis-associated adrenal injury in acute necrotizing pancreatitis
    Sheng Xu
    Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, PR China
    Pathol Res Pract 206:73-82. 2010
    This study investigated the mechanistic role of group IIA phospholipase A2 (sPLA2-IIA) in the process of pancreatitis-associated adrenal injury in acute necrotizing pancreatitis...
  23. ncbi Dissociation between the phospholipases C and A2 activities in stimulated platelets and their involvement in the arachidonic acid liberation
    A Faili
    , , Institut Pasteur, Paris, France
    Br J Haematol 88:149-55. 1994
    In previous work we have demonstrated that platelets depleted from secretory phospholipase A2 (sPLA2) produced similar amounts of thromboxane (Tx)B2 as control platelets upon stimulation by thrombin...
  24. ncbi Role of arachidonic acid and its metabolites in the priming of NADPH oxidase in human polymorphonuclear leukocytes by peritoneal dialysis effluent
    I Daniels
    Medical Research Centre, City Hospital, Nottingham, United Kingdom
    Clin Diagn Lab Immunol 5:683-9. 1998
    ..We were unable to determine the relative roles of secretory PLA2 (sPLA2) and cytosolic PLA2 (cPLA2) since the selective sPLA2 inhibitor scalaradial (0 to 100 microM) inhibited oxidase ..
  25. ncbi Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection
    T C Wang
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 114:675-89. 1998
    ..A mouse model of Helicobacter felis infection was used to study possible genetic determinants of the response to infection...
  26. ncbi Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2
    Olaf H Temmink
    Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Mol Cancer Ther 9:1047-57. 2010
    ..Surprisingly, microarray-mRNA analysis revealed a strong increase of secretory phospholipase-A2 (sPLA2; 47-fold), which was also found by reverse transcription-PCR (RT-PCR; 211-fold)...
  27. ncbi Cytosolic phospholipase A2 Group IValpha but not secreted phospholipase A2 Group IIA, V, or X induces interleukin-8 and cyclooxygenase-2 gene and protein expression through peroxisome proliferator-activated receptors gamma 1 and 2 in human lung cells
    Rafal Pawliczak
    Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:48550-61. 2004
    ..Chem. 277, 33153-33163). In this study we investigated the influence of cPLA2 and secreted phospholipase A2 (sPLA2) Group IIA, Group V, and Group X on IL-8 and COX-2 expression in human lung epithelial cells (A549 cells)...
  28. ncbi Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachido
    Won K Han
    Medical Services, Massachusetts General Hospital, Department of Medicine and Anesthesia, Harvard Medical School, Massachusetts, USA
    J Biol Chem 278:24153-63. 2003
    ..When sPLA2 and cPLA2alpha are both present, the effect of H2O2 is manifested by preferential release of AA compared with ..
  29. ncbi PLA2 mediated arachidonate free radicals: PLA2 inhibition and neutralization of free radicals by anti-oxidants--a new role as anti-inflammatory molecule
    B L Nanda
    Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India
    Curr Top Med Chem 7:765-77. 2007
    ..PLA2 enzymes have been classified into calcium dependent cPLA2 and sPLA2 and calcium independent iPLA2 forms...
  30. ncbi Increased levels of circulating microparticles in primary Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity
    Jeremie Sellam
    Rhumatologie, Hopital Bicetre, Assistance Publique Hopitaux de Paris AP HP, INSERM U802, Universite Paris Sud 11, 78 rue du General Leclerc, 94270, Le Kremlin Bicetre, France
    Arthritis Res Ther 11:R156. 2009
    ....
  31. ncbi Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, 94121, USA
    J Invest Dermatol 122:320-9. 2004
    ..Likewise, SC secretory phospholipase A2 (sPLA2) activity, measured with a fluorometric assay, is low at birth, but increases progressively (by 66%) over the ..
  32. ncbi Differential activation of human neutrophil cytosolic phospholipase A2 and secretory phospholipase A2 during priming by 1,2-diacyl- and 1-O-alkyl-2-acylglycerols
    M C Seeds
    Department of Internal Medicine Section on Pulmonary and Critical Care, Bowman Gray School of Medicine, Wake Forest University, Medical Center Blvd, Winston Salem, NC 27157, USA
    Biochim Biophys Acta 1394:224-34. 1998
    ..Therefore, we investigated the actions of EAG and AAG specifically on neutrophil cytosolic (cPLA2) and secretory (sPLA2) phospholipase A2s...
  33. ncbi In vivo protective role of human group IIa phospholipase A2 against experimental anthrax
    Alejandro Piris-Gimenez
    Unité Toxines et Pathogénie Bactérienne Centre National de la Recherche Scientifique Unité de Recherche Associée 2172, Paris, France
    J Immunol 175:6786-91. 2005
    ..anthracis infection in nonimmunized hosts. Group IIA secreted phospholipase A2 (sPLA2-IIA) is produced in particular by macrophages and possesses potent antibacterial activity especially against Gram-..
  34. ncbi A direct role for secretory phospholipase A2 and lysophosphatidylcholine in the mediation of LPS-induced gastric injury
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, University of Texas Medical School at Houston, Texas, USA
    Shock 33:634-8. 2010
    ..induces an increase in gastric permeability in parallel with the luminal appearance of secretory phospholipase A2 (sPLA2) and its product, lysophosphatidylcholine (lyso-PC)...
  35. ncbi Effect of IS-741 (a new synthetic antiinflammatory agent) on acute necrotizing pancreatitis in dogs. Significance of its inhibitory effect on cytosolic phospholipase A2
    S Isaji
    First Department of Surgery, Mie University School of Medicine, Tsu, Mie, Japan
    Digestion 60:47-51. 1999
    ..cPLA2 activity in the pancreas, lung and renal cortex was much lower in group B than in group A, but sPLA2 activity in these tissues did not differ significantly between the two groups...
  36. ncbi Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice
    Hiroyasu Sato
    Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    J Clin Invest 120:1400-14. 2010
    ..Here, we show that group III phospholipase A2 (sPLA2-III), a member of the secreted phospholipase A2 (sPLA2) family, is expressed in the mouse proximal epididymal ..
  37. ncbi sPLA2-X stimulates cutaneous melanocyte dendricity and pigmentation through a lysophosphatidylcholine-dependent mechanism
    Glynis A Scott
    Department of Dermatology, University or Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Invest Dermatol 126:855-61. 2006
    ..The predominant secretory phospholipase expressed by keratinocytes is group X secretory phospholipase A2 (sPLA2), which liberates large amounts of AA and the lysophospholipid lysophosphatidylcholine (LPC), ..
  38. ncbi Identification of differential expression of genes in hepatocellular carcinoma by suppression subtractive hybridization combined cDNA microarray
    Yuefang Liu
    Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing 210029, PR China
    Oncol Rep 18:943-51. 2007
    ..of methylglyoxal known as GLO1 and an enzyme which increases the formation of prostaglandin E(2) known as PLA2G10 were up-regulated in HCC...
  39. ncbi Secretory phospholipase A2 deposition on contact lenses and its effect on bacterial adhesion
    Emma B H Hume
    Vision Cooperative Research Centre, The University of New South Wales, Sydney, New South Wales, Australia
    Invest Ophthalmol Vis Sci 45:3161-4. 2004
    Secretory phospholipase A2 (sPLA2) is a potent antibacterial enzyme in tears and has been found to kill Staphylococcus aureus rapidly in vitro...
  40. ncbi Bee venom secretory phospholipase A2 and phosphatidylinositol-homologues cooperatively disrupt membrane integrity, abrogate signal transduction and inhibit proliferation of renal cancer cells
    Thomas Putz
    Department of Urology and kompetenzzentrum medizin tirol, Innsbruck Medical University, Innsbruck, Austria
    Cancer Immunol Immunother 56:627-40. 2007
    Bee venom secretory phospholipase A2 (bv-sPLA2) and phosphatidylinositol-(3,4)-bisphosphate (PtdIns(3,4)P2) act synergistically to induce cell death in tumour cells of various origins with concomitant stimulation of the immune system...
  41. ncbi MMP production in human fibrosarcoma cells and their invasiveness are regulated by group IB secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2
    Michal Gorovetz
    Department of Pharmacology, Hebrew University School of Pharmacy, Hebrew University Hadassah Medical School, Jerusalem, Israel 91120
    Front Biosci 13:1917-25. 2008
    ..Human fibrosarcoma cells were found to express and secrete type IB, IIA and V sPLA2. The cells were found also to express the M-type sPLA2 receptor...
  42. ncbi Deposition of lipid, protein, and secretory phospholipase A2 on hydrophilic contact lenses
    Hiroshi Mochizuki
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Eye Contact Lens 34:46-9. 2008
    ..The concentration of secretory phospholipase A2 (sPLA2), the enzyme that hydrolyzes phospholipids, in tears is known to exceed the levels found in serum by four orders ..
  43. ncbi Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis
    Barbara Balestrieri
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:6691-8. 2006
    We have previously reported that group V secretory phospholipase A2 (sPLA2) amplifies the action of cytosolic phospholipase A2(cPLA2) alpha in regulating eicosanoid biosynthesis by mouse peritoneal macrophages stimulated with zymosan (..
  44. ncbi Elevated levels of small, low-density lipoprotein with high affinity for arterial matrix components in patients with rheumatoid arthritis: possible contribution of phospholipase A2 to this atherogenic profile
    E Hurt-Camejo
    Goteborg University, Sweden
    Arthritis Rheum 44:2761-7. 2001
    ..This work studied the presence of inflammatory and atherogenic lipoprotein markers that could explain the high incidence of cardiovascular disease (CVD) reported in rheumatoid arthritis (RA) patients...
  45. ncbi Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation
    Hiroyasu Sato
    Department of Biological Sciences, Graduate School of Humanities and Sciences, Ochanomizu University, 2 1 1 Ohtsuka, Bunkyo ku, Tokyo 112 8610, Japan
    Biochem J 421:17-27. 2009
    PLA2 (phospholipase A2) group III is an atypical sPLA2 (secretory PLA2) that is homologous with bee venom PLA2 rather than with other mammalian sPLA2s...
  46. ncbi Secretory phospholipases A2 induce beta-glucuronidase release and IL-6 production from human lung macrophages
    M Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Immunol 164:4908-15. 2000
    ..Group IIA sPLA2 has been detected in inflammatory fluids, and its plasma level is increased in inflammatory diseases...
  47. ncbi Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice
    Jessica Escoffier
    Grenoble Institute of Neuroscience, INSERM U836, Grenoble, France
    J Clin Invest 120:1415-28. 2010
    ..Several studies have suggested a role for members of the secreted phospholipase A2 (sPLA2) family in capacitation, acrosome reaction (AR), and fertilization, but the molecular nature of these enzymes and ..
  48. ncbi Effects of low molecular weight sulfated galactan fragments from Botryocladia occidentalis on the pharmacological and enzymatic activity of sPLA2 from Crotalus durissus cascavella
    M H Toyama
    UNESP, Campus do Litoral Paulista, São Vicente, Brasil
    Protein J 29:567-71. 2010
    ..and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2...
  49. ncbi A natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains
    B P Kennedy
    Department of Biochemistry and Molecular Biology, Merck Frosst Center for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    J Biol Chem 270:22378-85. 1995
    The synovial fluid or group II secretory phospholipase A2 (sPLA2) has been implicated as an important agent involved in a number of inflammatory processes...
  50. ncbi Bile acids cause secretory phospholipase A2 activity enhancement, revertible by exogenous surfactant administration
    Daniele De Luca
    Pediatric Intensive Care Unit, Department of Anaesthesiology and Intensive Care, University Hospital A Gemelli, Catholic University of the Sacred Heart, L go A Gemelli 8, 00168, Rome, Italy
    Intensive Care Med 35:321-6. 2009
    ..Secretory phospholipase A2 (sPLA2) is now known as a key enzyme in the lung injury pathways and is supposed to be responsible for surfactant ..
  51. ncbi Therapeutic time-window of a group IIA phospholipase A2 inhibitor in rabbit acute lung injury: correlation with lung surfactant protection
    S Furue
    Discovery Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    Crit Care Med 29:719-27. 2001
    OBJECTIVE: We attempted to determine whether group IIA secretory phospholipase A2 (sPLA2-IIA) blockade after the onset of lung injury exerted therapeutic efficacy in the treatment of oleic acid (OA)-induced acute lung injury by using S-..
  52. ncbi Distribution of the phospholipase A2 receptor messenger RNA in human gestational tissues
    E K Moses
    Department of Perinatal Medicine, Royal Women s Hospital, Carlton, Victoria, Australia
    Placenta 19:35-40. 1998
    Recently, a model has been proposed for the involvement of secretory phospholipase A2 (sPLA2) in the onset of and/or progression of human labour via the metabolism of cell membrane glycerophospholipids to generate biologically active, ..
  53. ncbi Inhibition of interleukin-1beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the proto-oncogene BCL-6
    Lucas Ravaux
    UMR Physiologie et Physiopathologie, Universite Pierre et Marie Curie, CNRS, 7 quai Saint Bernard, 75252 Paris, France
    Mol Cell Biol 27:8374-87. 2007
    ..during atherosclerosis is characterized by the release of large amounts of group IIA secretory phospholipase A2 (sPLA2-IIA)...
  54. ncbi Complement-induced phospholipase A2 activation in experimental membranous nephropathy
    A V Cybulsky
    Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
    Kidney Int 57:1052-62. 2000
    ..By analogy, in cultured rat GEC, sublytic C5b-9 injures plasma membranes and releases arachidonic acid (AA) and eicosanoids, due to activation of phospholipase A2 (PLA2). This study addresses the mechanisms of PLA2 activation...
  55. ncbi Group IIA secretory PLA2 inhibition by ursolic acid: a potent anti-inflammatory molecule
    A Nataraju
    Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore 570 006, Karnataka, India
    Curr Top Med Chem 7:801-9. 2007
    ..However its interaction with pro-inflammatory PLA2 is not known. Ursolic acid inhibited secretory PLA2 (sPLA2) enzymes purified from Vipera russelli, Naja naja venom and human pleural fluid and synovial fluid...
  56. ncbi Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesis
    Sang Ho Choi
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 98:801-11. 2006
    ..in brain AA cascade, we examined the expression and activity of COX-2 and phospholipase A2 enzymes (cPLA2 and sPLA2), as well as the expression of terminal prostaglandin E synthases (cPGES, mPGES-1, and - 2) in wild type and COX-1(..
  57. ncbi Differential effects of lysophospholipids on exocytosis in rat PC12 cells
    May Thu Ma
    Department of Oral and Maxillofacial Surgery, National University of Singapore, Singapore, Singapore
    J Neural Transm 117:301-8. 2010
    Secretory phospholipase A2 (sPLA2) activity is present in the CNS and the sPLA2-IIA isoform has been shown to induce exocytosis in cultured hippocampal neurons...
  58. ncbi Increased hepatic cholesterol accumulation in transgenic mice overexpressing human secretory phospholipase A2 group IIA
    Rolf Eckey
    Institute for Clinical Chemistry and Laboratory Medicine, Medical Faculty, Technical University of Dresden, Dresden, Germany
    Inflammation 28:59-65. 2004
    It has been demonstrated in transgenic mice that the overexpression of human phospholipase A2 group IIA (sPLA2), an acute-phase reactant, is associated with depressed plasma cholesterol levels, altered lipoprotein compositions, and ..
  59. ncbi Activation of phospholipase A2 in human neutrophils by polyunsaturated fatty acids and its role in stimulation of superoxide production
    B S Robinson
    Department of Immunopathology, Women s and Children s Hospital, 72 King William Road, North Adelaide, South Australia 5006, Australia
    Biochem J 336:611-7. 1998
    ..C20:4(n-6) or C22:6(n-3) evoked activation of the 85 kDa cytosolic PLA2 (cPLA2) and the 14 kDa secretory PLA2 (sPLA2), but not the cytosolic Ca2+-independent PLA2. In contrast, C20:0 did not activate any of the PLA2 isoforms...
  60. ncbi Synthesis of sn-1 functionalized phospholipids as substrates for secretory phospholipase A2
    Lars Linderoth
    Department of Chemistry, Technical University of Denmark, Denmark
    Chem Phys Lipids 146:54-66. 2007
    Secretory phospholipase A2 (sPLA2) represents a family of small water-soluble enzymes that catalyze the hydrolysis of phospholipids in the sn-2 position liberating free fatty acids and lysophospholipids...
  61. ncbi Uteroglobin binding proteins: regulation of cellular motility and invasion in normal and cancer cells
    G C Kundu
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    Ann N Y Acad Sci 923:234-48. 2000
    ..While its anti-inflammatory effects, in part, stem from the inhibition of soluble phospholipase A2 (sPLA2) activity, the mechanism(s) of its antichemotactic effects is not clearly understood...
  62. ncbi Mechanisms of lysophosphatidic acid production
    Junken Aoki
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Semin Cell Dev Biol 15:477-89. 2004
    ..However, apparently certain extracellular phospholipases such as secretory PLA2 (sPLA2-IIA), membrane-associated PA-selective PLA1 (mPA-PLA1), lecithin-cholesterol acyltransferase (LCAT), and lysoPLD ..
  63. ncbi [Allergy and neurotoxicity induced by bee sting. Case report and literature review]
    Martha Patricia Valencia Zavala
    Servicio de alergia e inmunologia clinica, Hospital General de Mexico
    Rev Alerg Mex 54:177-85. 2007
    ..That neurotoxic venom secretory phospholipases A2 (sPLA2) have specific receptors in brain membranes called N-type receptors that are likely to play a role in the ..
  64. ncbi Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis
    Hiroyasu Sato
    Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
    J Biol Chem 283:33483-97. 2008
    ..that phosphatidylcholine was efficiently converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E...
  65. ncbi Reduced complement activation during cardiopulmonary bypass does not affect the postoperative acute phase response
    J van den Goor
    Department of Cardio Thoracic Surgery, Academic Medical Center of the University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Cardiothorac Surg 26:926-31. 2004
    ..CPB circuits contained either non-coated- (UMS), Carmeda- (BPS) or Trillium-coated oxygenators (BAS)...
  66. ncbi Restoration of enzymatic activity in a Ser-49 phospholipase A2 homologue decreases its Ca(2+)-independent membrane-damaging activity and increases its toxicity
    Toni Petan
    Department of Molecular and Biomedical Sciences, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biochemistry 46:12795-809. 2007
    Ammodytin L (AtnL) is a Ser-49 secretory phospholipase A2 (sPLA2) homologue with myotoxic activity...
  67. ncbi sPLA2-IIa is an inflammatory mediator when the ocular surface is compromised
    Dongmei Chen
    Department of Ophthalmology, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Eye Res 88:880-8. 2009
    b>sPLA2-IIa is an enzyme at high concentration in tears that has been known as an innate barrier of the ocular surface against microbial infection...
  68. ncbi Assessment of systemic inflammatory response (SIR) in patients undergoing radiofrequency ablation or partial liver resection for liver tumors
    M C Jansen
    Department of Surgery, Academic Medical Center, Meibergdreef 9, 1109 AZ Amsterdam, The Netherlands
    Eur J Surg Oncol 34:662-7. 2008
    ..Aim of this study was to assess the degree of SIR after radiofrequency ablation (RFA) in comparison with major (MR) or minor (mR) liver resection...
  69. ncbi A-002 (Varespladib), a phospholipase A2 inhibitor, reduces atherosclerosis in guinea pigs
    Jose O Leite
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    BMC Cardiovasc Disord 9:7. 2009
    The association of elevated serum levels of secretory phospholipase A2 (sPLA2) in patients with cardiovascular disease and their presence in atherosclerotic lesions suggest the participation of sPLA2 enzymes in this disease...
  70. ncbi Vav3 oncogene is involved in regulation of secretory phospholipase A2-IIa expression in prostate cancer
    Zhongyun Dong
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Oncol Rep 25:1511-6. 2011
    Our previous study revealed that Vav3 oncogene and secretory phospholipase A2-IIa (sPLA2-IIa) are overexpressed in androgen-independent prostate cancer cells relative to their androgen-dependent counterparts and contribute to development ..
  71. ncbi Therapeutic potential of peptides with neutralizing ability towards the venom and toxin (CaTx-I) of crotalus adamanteus
    Ramar Perumal Samy
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Curr Top Med Chem 11:2540-55. 2011
    ..0001 ?M) using a Cayman chemical human secretory phospholipase A2 (sPLA2, Type II) assay kit...
  72. ncbi Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease
    Sarah Gora
    INSERM, UMRS937, UPMC Université Paris 06 and Faculté de Médecine Pierre et Marie Curie, 91, Boulevard de l Hopital, 75634, Paris, France
    J Mol Med (Berl) 87:723-33. 2009
    ..To elucidate whether hGX sPLA2 plays a causative role in coronary artery disease (CAD), we screened the human PLA2G10 gene to identify polymorphisms and possible associations with CAD end-points in a prospective study, AtheroGene...
  73. ncbi Correlation between sPLA2-IIA and phosgene-induced rat acute lung injury
    Hong Li Chen
    Department of Toxicology, Fourth Military Medical University, Xi an, China
    Inhal Toxicol 21:374-80. 2009
    ..Moreover, the trend of this elevation correlated well with the severity of lung injury. These results indicate that sPLA(2)-IIA probably participates in phosgene-induced acute lung injury...
  74. ncbi Nanostructured lipid carriers as delivery system for the phopholipase A2 inhibitors PX-18 and PX-13 for dermal application
    J Pardeike
    Department of Pharmaceutical Technology, Biopharmaceutics and NutriCosmetics, Freie Universitat Berlin, Germany
    Pharmazie 66:357-61. 2011
    PX-18 and PX-13 are secretory phospholipase A2-IIA (sPLA2-IIA) inhibitors. An increased expression of sPLA2 in psoriatic skin has been reported. The selective inhibition of this enzyme is a new therapeutic approach...
  75. ncbi Secretory phospholipase A2 hydrolysis of phospholipid analogues is dependent on water accessibility to the active site
    Gunther H Peters
    Department of Chemistry, MEMPHYS Center for Biomembrane Physics, Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Am Chem Soc 129:5451-61. 2007
    ..of the glycerol backbone has been synthesized and shown to be a good substrate for secretory phospholipase A2 (sPLA2)...
  76. ncbi Phospholipase A2-like activity of human bocavirus VP1 unique region
    Xiao wang Qu
    Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, PR China
    Biochem Biophys Res Commun 365:158-63. 2008
    ..The purified VP1 unique protein (VP1U) showed a typical Ca2+-dependent secreted PLA2-like (sPLA2) activity, which was inhibited by sPLA2-specific inhibitors in a time-dependent manner...
  77. ncbi Quercetin as an inhibitor of snake venom secretory phospholipase A2
    Camila Aparecida Cotrim
    Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas, Rua Monteiro Lobato 255, Campinas, SP, Brazil
    Chem Biol Interact 189:9-16. 2011
    ..we evaluated the effects of the flavonoid quercetin on Crotalus durissus terrificus secretory phospholipase A2 (sPLA2), an important protein involved in the release of arachidonic acid from phospholipid membranes...
  78. ncbi Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease
    Sonia Chalbot
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314 6399, USA
    Clin Chem 55:2171-9. 2009
    ....
  79. ncbi Extracellular phospholipases in atherosclerosis
    Sonia Athina Karabina
    INSERM UMRS 937, Université Pierre et Marie Curie UPMC Paris 6, Faculte de Medecine Pierre et Marie Curie, 91 Boulevard de l Hopital, Paris 75634 Cedex 13, France
    Biochimie 92:594-600. 2010
    ..Among secreted PLA2s (sPLA2), the group X sPLA2 (PLA2GX), due to its very high activity towards phosphatidylcholine the main phospholipid of ..
  80. ncbi Kinetic properties of pancreatic and intestinal sPLA2 from chicken and mammals using the monomolecular film technique
    Aida Karray
    Laboratoire de Biochimie et de Genie Enzymatique des Lipases, Ecole Nationale d Ingenieurs de Sfax, Sfax, Tunisia
    J Colloid Interface Sci 363:620-5. 2011
    The interfacial kinetic and binding data for the pancreatic and intestinal sPLA2 from bird and mammals show that these enzymes have dramatically different ability to bind and hydrolyse phospholipids...
  81. ncbi Crystal structure of Natratoxin, a novel snake secreted phospholipaseA2 neurotoxin from Naja atra venom inhibiting A-type K+ currents
    Pu Hu
    Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, People s Republic of China
    Proteins 72:673-83. 2008
    ..Here, a novel snake sPLA2 peptide neurotoxin, Natratoxin, composed of 119 amino acid residues and purified from Naja atra venom was reported...
  82. ncbi Simvastatin inhibits sPLA2 IIa expression in aorta and myocardium
    Li Wei-hua
    Department of Cardiology, The First Hospital of Xiamen, Fujian Medical University, The Cardiovascular Institute of Xiamen, China
    Arch Med Res 40:67-72. 2009
    Group IIa secretory phospholipase A2 (sPLA2 IIa) induces atherosclerosis by altering systemic lipoprotein mechanism...
  83. ncbi Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice
    Melissa Zack
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
    Atherosclerosis 214:58-64. 2011
    ..Specific interventions that prevent AAA progression remain to be identified. In this study, we tested the hypothesis that Group X secretory phospholipase A(2) (GX sPLA(2)), an enzyme implicated in inflammatory processes, mediates AAA...
  84. ncbi Effects of human parvovirus B19 VP1 unique region protein on macrophage responses
    Bor Show Tzang
    Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
    J Biomed Sci 16:13. 2009
    Activity of secreted phospholipase A (sPLA2) has been implicated in a wide range of cellular responses. However, little is known about the function of human parvovirus B19-VP1 unique region (VP1u) with sPLA2 activity on macrophage.
  85. ncbi Phospholipase A2 subclasses in acute respiratory distress syndrome
    Eirini Kitsiouli
    Department of Biological Applications and Technologies, School of Sciences and Technologies, University of Ioannina, Greece
    Biochim Biophys Acta 1792:941-53. 2009
    ..lung damage and others have a role in lung surfactant recycling preserving lung function: Secreted forms (groups sPLA2-IIA, -V, -X) can directly hydrolyze surfactant phospholipids...
  86. ncbi Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells
    Caroline E von Allmen
    Cytos Biotechnology AG, Wagistrasse 25, CH 8952 Schlieren, Switzerland
    Proc Natl Acad Sci U S A 106:11673-8. 2009
    ..Here, we show that secreted phospholipase A2 (sPLA2)-IID is selectively produced by Tregs...
  87. ncbi Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X
    Ying Lai
    Division of Pulmonary and Critical Care, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 285:41491-500. 2010
    ..Transactivation of eosinophils by sPLA(2)-X may be an important mechanism leading to CysLT formation in the airways of patients with asthma...
  88. ncbi Phospholipase A2 in chamber angle of normal eyes and patients with primary open angle glaucoma and exfoliation glaucoma
    Seppo Rönkkö
    Department of Ophthalmology, University of Kuopio, Kuopio, Finland
    Mol Vis 13:408-17. 2007
    ..Therefore, our aim was to examine the expression of group IIA secretory PLA2 (sPLA2-IIA), group V secretory PLA2 (sPLA2-V), calcium-independent PLA2 (iPLA2), and cytosolic PLA2 (cPLA2) type in the ..
  89. ncbi Lysophosphatidylcholine mediates melanocyte dendricity through PKCzeta activation
    Glynis A Scott
    Department of Dermatology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Invest Dermatol 127:668-75. 2007
    ..Secretory phospholipase-A2 type X (sPLA2-X) is released by epidermal keratinocytes and we have shown that lysophosphatidylcholine (LPC), the main ..
  90. ncbi Effects of an endothelin B receptor agonist on secretory phospholipase A2-IIA-induced apoptosis in cortical neurons
    Tatsurou Yagami
    Discovery Research Laboratories, Shionogi and Co, Ltd, 12 4 Sagisu 5 chome, Fukushima ku, Osaka 553 0002, Japan
    Neuropharmacology 48:291-300. 2005
    ..Human group IIA secretory phospholipase A2 (sPLA2-IIA) is expressed in the cerebral cortex after brain ischemia and causes neuronal cell death via apoptosis...
  91. ncbi Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition
    Stijn A I Ghesquiere
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Lipid Res 46:201-10. 2005
    ..Group IIa secretory phospholipase A2 (sPLA2 IIa) is a key candidate player in the enzymatic modification of low density lipoproteins...
  92. ncbi Effect of a selective inhibitor of secretory phospholipase A2, S-5920/LY315920Na, on experimental acute pancreatitis in rats
    Yasuhiko Tomita
    Discovery Research Laboratories, Shionogi and Co, Ltd, 5 12 4 Sagisu, Fukushima ku, Osaka 553 0002, Japan
    J Pharmacol Sci 96:144-54. 2004
    We investigated the efficacy of a potent inhibitor of secretory phospholipase A2 (sPLA2), S-5920/LY315920Na, in an experimental model of acute pancreatitis in rats...
  93. ncbi Endocytic properties of the M-type 180-kDa receptor for secretory phospholipases A2
    E Zvaritch
    Institut de Pharmacologie Moleculaire et Cellulaire, Valbonne, France
    J Biol Chem 271:250-7. 1996
    Endocytic properties of the M-type 180-kDa receptor for secretory phospholipases A2 (sPLA2) were first investigated in rabbit myocytes that express it at high levels...
  94. ncbi Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study
    Maung Maung Thwin
    Venom and Toxin Research Program, Department of Anatomy, National University of Singapore, Singapore
    Arthritis Res Ther 6:R282-94. 2004
    We evaluated the therapeutic effect of secretory phospholipase A2 (sPLA2)-inhibitory peptide at a cellular level on joint erosion, cartilage destruction, and synovitis in the human tumor necrosis factor (TNF) transgenic mouse model of ..
  95. ncbi Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption
    Yoshiyuki Satake
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:16488-94. 2004
    Conclusions regarding the contribution of low molecular weight secretory phospholipase A2 (sPLA2) enzymes in eicosanoid generation have relied on data obtained from transfected cells or the use of inhibitors that fail to discriminate ..
  96. ncbi Secreted phospholipase A2-induced neurotoxicity and epileptic seizures after intracerebral administration: an unexplained heterogeneity as emphasized with paradoxin and crotoxin
    F Dorandeu
    Department of Toxicology, Unit of Neuropharmacology, Centre de Recherches du Service de Sante des Armees, La Tronche, France
    J Neurosci Res 54:848-62. 1998
    After intracerebral injection, some toxic secreted phospholipases A2 (sPLA2) can induce epileptic seizures which bases are currently ill known...
  97. ncbi Cloning and recombinant expression of a novel mouse-secreted phospholipase A2
    E Valentin
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, UPR 411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 274:19152-60. 1999
    ..Here, we report the cloning and expression of a novel sPLA2 isolated from mouse thymus...
  98. ncbi Determination of enzymatic activity and properties of secretory phospholipase A2 by capillary electrophoresis
    S Choi
    Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea
    J Chromatogr A 853:285-93. 1999
    ..CE) system coupled with a diode array UV detector was used for the assay of secretory phospholipase A2 (sPLA2) activity...
  99. ncbi Augmented prostaglandin E2 generation resulting from increased activities of cytosolic and secretory phospholipase A2 and induction of cyclooxygenase-2 in interleukin-1 beta-stimulated rat calvarial cells during the mineralizing phase
    S Higashi
    Product Research Laboratory, Chugai Pharmaceutical Co Ltd, Toshima, Tokyo, Japan
    Inflamm Res 49:102-11. 2000
    ..To assess prostaglandin (PG) E2 production by osteoblasts during the mineralizing phase after interleukin (IL)-1beta stimulation, using an in vitro system of rat calvarial cells cultured for 21 days...
  100. ncbi Genomic structure and evolution of a novel gene (PLA2L) with duplicated phospholipase A2-like domains
    P E Kowalski
    Terry Fox Laboratory, B C Cancer Agency, Vancouver, British Columbia, Canada
    Genomics 39:38-46. 1997
    In a previous study, we isolated a novel human cDNA with two domains of homology to secreted phospholipase A2 (sPLA2) embedded within a much larger open reading frame...
  101. ncbi Expression of group IIA secretory phospholipase A2 is elevated in prostatic intraepithelial neoplasia and adenocarcinoma
    Jiazhong Jiang
    Department of Pathology, Division of Biostatistics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Pathol 160:667-71. 2002
    ..Group IIa secretory PLA2 (sPLA2) can generate arachidonate from cellular phospholipids...

Research Grants72

  1. Amyloid Induced Proinflam. Pathways /Cerebrovasculature
    Michael Mullan; Fiscal Year: 2003
    ..peripheral mammalian artery, freshly solubilized B-amyloid (Ar) peptides stimulate a pro-inflammatory pathway (sPLA2-MAPK-cPLA2-AA-LOX/COX) involving activation of secretory phospholipase A2 (PLA2), mitogen-activated protein kinase ..
  2. Biochemical Studies of 14-kDa Phospholipases A2
    Michael Gelb; Fiscal Year: 2007
    ..Mammals also contain an sPLA2 receptor, the M-type sPLA2 receptor, which was discovered by use of venom sPLA2s...
  3. Secretory Phospholipase A2s in Airway Pathophysiology
    Teal S Hallstrand; Fiscal Year: 2010
    ..Recently, 9 secretory PLA2s (sPLA2)s have been identified that act in concert with the well-described group IVa cytosolic PLA2 (cPLA2a) to release AA ..
  4. Aging Stratum Corneum pH and Barrier Function
    Theodora M Mauro; Fiscal Year: 2010
    ..the combined activity of two endogenous mechanisms, the Na+/H+ antiporter (NHE1) and the secretory phospholipase (sPLA2) enzymes, although the relative contribution of each agent in supplying SC acidity to specific regions of the SC ..
  5. PROTEASE INHIBITOR RELATED DYSLIPIDEMIA
    Christine Wanke; Fiscal Year: 2009
    ..We propose to expand our studies of chronic inflammation adding CRP isoforms and sPLA2 to the determination of CRP to examine the association of these with atherogenic lipid profiles and with abnormal ..
  6. Stratum Corneum Acidification in the Neonate
    Kenneth Feingold; Fiscal Year: 2007
    ..1) histidase conversion of histidine to urocanic acid, 2) metabolism of phospholipids to free fatty acids by sPLA2, and/or 3) transport of hydrogen ions into the extracellular space by NHE1, are not yet fully developed in newborn ..
  7. Group V sPla2 in Inflammation and Innate Immunity
    Barbara Balestrieri; Fiscal Year: 2007
    ..Using group V secretory PLA2 (sPLA2)-null mouse peritoneal macrophages we showed that group V sPLA2 amplifies the action of cytosolic PLA2alpha (cPLA2 ..
  8. PROTEASE INHIBITOR RELATED DYSLIPIDEMIA
    Christine Wanke; Fiscal Year: 2007
    ..We propose to expand our studies of chronic inflammation adding CRP isoforms and sPLA2 to the determination of CRP to examine the association of these with atherogenic lipid profiles and with abnormal ..
  9. PROTEASE INHIBITOR RELATED DYSLIPIDEMIA
    Christine A Wanke; Fiscal Year: 2010
    ..We propose to expand our studies of chronic inflammation adding CRP isoforms and sPLA2 to the determination of CRP to examine the association of these with atherogenic lipid profiles and with abnormal ..
  10. Novel Direct Approaches Toward Bioactive Heterocycles
    Vladimir Gevorgyan; Fiscal Year: 2010
    ..various diversely substituted indolizines not easily available by existing techniques, potential selective group V sPLA2 inhibitors;lamellarin D and its analogs;novel lamellarin-campthothecin hybrid pentacyclic scaffolds, potential ..
  11. Smooth muscle cell lipid metabolism and serum amyloid A
    Barbara Schreiber; Fiscal Year: 2007
    ..Our gene microarray analysis showed that SAA induces expression of secretory phospholipase A2 (sPLA2) and calcium-dependent cytosolic phospholipase A2 (cPLA2)...
  12. Smooth muscle cell lipid metabolism and serum amyloid A
    Barbara M Schreiber; Fiscal Year: 2010
    ..Our gene microarray analysis showed that SAA induces expression of secretory phospholipase A2 (sPLA2) and calcium-dependent cytosolic phospholipase A2 (cPLA2)...
  13. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..membrane and mitochondrial phospholipase A2 (PLA2) that is raM-Ca 2+ dependent (characteristic of secretory PLA2; sPLA2), supporting the hypothesis and Aim 1...
  14. Regulation of HMGB1 Release in Endotoxemia
    Haichao Wang; Fiscal Year: 2007
    ..endotoxin, which stimulates macrophages to sequentially release TNF,IFN-gamma, secretory phospholipase A2 (sPLA2), nitric oxide, and HMGB1...
  15. Regulation of HMGB1 Release in Endotoxemia
    Haichao Wang; Fiscal Year: 2007
    ..endotoxin, which stimulates macrophages to sequentially release TNF, IFN-gamma, secretory phospholipase A2 (sPLA2), nitric oxide, and HMGB1...
  16. Regulation of HMGB1 Release in Endotoxemia
    Haichao Wang; Fiscal Year: 2009
    ..endotoxin, which stimulates macrophages to sequentially release TNF, IFN-gamma, secretory phospholipase A2 (sPLA2), nitric oxide, and HMGB1...
  17. Regulation of HMGB1 Release in Endotoxemia
    Haichao Wang; Fiscal Year: 2010
    ..endotoxin, which stimulates macrophages to sequentially release TNF, IFN-gamma, secretory phospholipase A2 (sPLA2), nitric oxide, and HMGB1...
  18. The Impact of Omega three Fatty Acids on Vascular Function and cIMT in HIV
    Christine Wanke; Fiscal Year: 2009
    ..on HDL-C levels, HDL subprofiles, composition of membrane phospholipids, chronic inflammation as measured by CRP, sPLA2 and by levels of arachidonic acid. 3...
  19. The Impact of Omega three Fatty Acids on Vascular Function and cIMT in HIV
    Christine A Wanke; Fiscal Year: 2010
    ..on HDL-C levels, HDL subprofiles, composition of membrane phospholipids, chronic inflammation as measured by CRP, sPLA2 and by levels of arachidonic acid. 3...
  20. MECHANISMS OF AIRWAY HYPERRESPONSIVENESS
    Alan Leff; Fiscal Year: 2001
    ..preliminary studies indicate that ligation to FN causes increased activity of cytosolic PLA2 (cPLA2) and increased sPLA2 activity with corresponding translocation of these isoforms...
  21. 5-LIPOXYGENASE PRODUCTS IN ASTHMATIC IMMUNE RESPONSE
    William Henderson; Fiscal Year: 2002
    ..important in development of allergic inflammation and AHR? and b) Will blockade of secretory phospholipase A2 (sPLA2) and PAF inhibit allergic lung inflammation and AHR? and Specific Aim 3...
  22. Group V Phospholipase A2 and Pulmonary Inflammation
    Jonathan Arm; Fiscal Year: 2006
    ..there is a body of evidence that cPLA2 requires the co-ordinate action of a low molecular weight, secretory PLA2 (sPLA2), most likely group V sPLA2. Group V sPLA2 is expressed by both mast cells and macrophages...
  23. Group X sPLA2: Regulator of lipolysis and glucose homeostasis
    Nancy R Webb; Fiscal Year: 2010
    ..Based on our preliminary findings, we hypothesize that GX sPLA2 expressed by adipose tissue macrophages modulates the equilibrium between adipocyte lipid storage and lipid ..
  24. Group X sPLA2: Regulator of lipolysis and glucose homeostasis
    Nancy Webb; Fiscal Year: 2009
    ..Based on our preliminary findings, we hypothesize that GX sPLA2 expressed by adipose tissue macrophages modulates the equilibrium between adipocyte lipid storage and lipid ..
  25. Group V Phospholipase A2 and Pulmonary Inflammation
    Howard R Katz; Fiscal Year: 2010
    ..application is to understand the biological function(s) of an enzyme termed secretory group V phospholipase A2 (sPLA2), particularly as it pertains to control of infections and pulmonary inflammation...
  26. Group V Phospholipase A2 and Pulmonary Inflammation
    Howard Katz; Fiscal Year: 2009
    ..application is to understand the biological function(s) of an enzyme termed secretory group V phospholipase A2 (sPLA2), particularly as it pertains to control of infections and pulmonary inflammation...
  27. Action of Phospholipase A2 on Apoptotic Cells
    John Bell; Fiscal Year: 2005
    Secretory phospholipase A2 (sPLA2) binds to lipid bilayers and catalyzes hydrolysis of phospholipids. Normally, cells resist the enzyme's action, but they become susceptible during apoptosis or trauma...
  28. Novel Direct Approaches Toward Bioactive Heterocycles
    Vladimir Gevorgyan; Fiscal Year: 2007
    ..various diversely substituted indolizines not easily available by existing techniques, potential selective group V sPLA2 inhibitors; lamellarin D and its analogs, and novel lamellarin-campthothecin hybrid pentacyclic scaffolds, ..
  29. Novel Direct Approaches Toward Bioactive Heterocycles
    Vladimir Gevorgyan; Fiscal Year: 2009
    ..various diversely substituted indolizines not easily available by existing techniques, potential selective group V sPLA2 inhibitors; lamellarin D and its analogs, and novel lamellarin-campthothecin hybrid pentacyclic scaffolds, ..
  30. PHOSPHOLIPASE ACTIVATION IN ASPIRIN INTOLERANT ASTHMA
    ESTHER LANGMACK; Fiscal Year: 2002
    ..The relative contribution of the two main phospholipases involved in AA release, secretory phospholipase A2 (sPLA2) and cytosolic phospholipase A2 (cPLA2), to AA release and AA-derived mediator production in AIA, will be ..
  31. BIOPHYSICAL PRINCIPLES OF PERISTALTIC PHENOMENA
    Piero Biancani; Fiscal Year: 2002
    ..tone may be associated with activity of a low molecular weight pancreatic-like (type 1) secreted phospholipase A2 (sPLA2) and production of arachidonic acid (AA), which is metabolized to prostaglandins and thromboxanes...
  32. Phospholipase A2-mediated surfactant hydrolysis and dysfunction in ALI and ARDS
    ROBERT DUNCAN HITE; Fiscal Year: 2010
    ..Secretory phospholipases A2 (sPLA2) are potent mediators of surfactant injury, and are increased in the BAL fluid in ALI/ARDS...
  33. Phospholipase A2-mediated surfactant hydrolysis and dysfunction in ALI and ARDS
    ROBERT HITE; Fiscal Year: 2007
    ..Secretory phospholipases A2 (sPLA2) are potent mediators of surfactant injury, and are increased in the BAL fluid in ALI/ARDS...