phospholipid transfer protein

Summary

Gene Symbol: phospholipid transfer protein
Description: phospholipid transfer protein
Alias: BPIFE, HDLCQ9, BPI fold containing family E, lipid transfer protein II
Species: human

Top Publications

  1. ncbi Active plasma phospholipid transfer protein is associated with apoA-I- but not apoE-containing lipoproteins
    Marian C Cheung
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA
    J Lipid Res 47:1315-21. 2006
  2. ncbi Elevation of plasma phospholipid transfer protein increases the risk of atherosclerosis despite lower apolipoprotein B-containing lipoproteins
    Jessica Lie
    Departments of Biochemistry, Erasmus University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Lipid Res 45:805-11. 2004
  3. ncbi Phospholipid transfer protein interacts with and stabilizes ATP-binding cassette transporter A1 and enhances cholesterol efflux from cells
    John F Oram
    Department of Medicine, University of Washington, Seattle, Washington 98195 6426, USA
    J Biol Chem 278:52379-85. 2003
  4. ncbi Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP)
    Minna Kärkkäinen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, Helsinki FIN 00251, Finland
    J Biol Chem 277:15413-8. 2002
  5. ncbi Acute elevation of plasma PLTP activity strongly increases pre-existing atherosclerosis
    Matthijs Moerland
    Department Cell Biology and Genetics Vascular Surgery, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 28:1277-82. 2008
  6. ncbi Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis
    Kevin D O'Brien
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Wash, USA
    Circulation 108:270-4. 2003
  7. ncbi PLTP secreted by HepG2 cells resembles the high-activity PLTP form in human plasma
    Sarah Siggins
    National Public Health Institute, Department of Molecular Medicine, Biomedicum, P O Box 104, Fin 00251 Helsinki, Finland
    J Lipid Res 44:1698-704. 2003
  8. ncbi Elevation of systemic PLTP, but not macrophage-PLTP, impairs macrophage reverse cholesterol transport in transgenic mice
    Hannelore Samyn
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Atherosclerosis 204:429-34. 2009
  9. ncbi Reduction of HDL levels lowers plasma PLTP and affects its distribution among lipoproteins in mice
    Hannelore Samyn
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Biochim Biophys Acta 1791:790-6. 2009
  10. ncbi Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells
    Catherine M Desrumaux
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Lipid Res 44:1453-61. 2003

Research Grants

  1. FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORS
    Sergio Fazio; Fiscal Year: 2009
  2. Molecular and Funcitonal Analysis of Human A-I
    Vassilis I Zannis; Fiscal Year: 2010
  3. FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORS
    Sergio Fazio; Fiscal Year: 2010
  4. IMMUNOCHEMICAL STRUCTURE/FUNCTION OF APOLIPOPROTEIN A-I
    Linda Curtiss; Fiscal Year: 2007
  5. PROTEINS OF COAGULATION PATHWAYS
    John H Griffin; Fiscal Year: 2010
  6. MECHANISM OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 1993
  7. ENZYMATIC REACTIONS OF PLASMA LIPOPROTEINS
    HENRY POWNALL; Fiscal Year: 2000
  8. Molecular Mechanisms of Biogenesis of Apolipoprotein B-Containing Lipoproteins
    Nassrin Dashti; Fiscal Year: 2009
  9. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009
  10. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications147 found, 100 shown here

  1. ncbi Active plasma phospholipid transfer protein is associated with apoA-I- but not apoE-containing lipoproteins
    Marian C Cheung
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA
    J Lipid Res 47:1315-21. 2006
    Plasma phospholipid transfer protein (PLTP) is a multifaceted protein with diverse biological functions. It has been shown to exist in both active and inactive forms...
  2. ncbi Elevation of plasma phospholipid transfer protein increases the risk of atherosclerosis despite lower apolipoprotein B-containing lipoproteins
    Jessica Lie
    Departments of Biochemistry, Erasmus University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Lipid Res 45:805-11. 2004
    Plasma phospholipid transfer protein (PLTP) transfers phospholipids between lipoproteins and mediates HDL conversion. PLTP-overexpressing mice have increased atherosclerosis...
  3. ncbi Phospholipid transfer protein interacts with and stabilizes ATP-binding cassette transporter A1 and enhances cholesterol efflux from cells
    John F Oram
    Department of Medicine, University of Washington, Seattle, Washington 98195 6426, USA
    J Biol Chem 278:52379-85. 2003
    ..Thus, PLTP mimics apolipoproteins in removing cellular lipids by the ABCA1 pathway, except that PLTP acts more as an intermediary in the transfer of cellular lipids to lipoprotein particles...
  4. ncbi Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP)
    Minna Kärkkäinen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, Helsinki FIN 00251, Finland
    J Biol Chem 277:15413-8. 2002
    Plasma phospholipid transfer protein (PLTP) plays an important role in lipoprotein metabolism...
  5. ncbi Acute elevation of plasma PLTP activity strongly increases pre-existing atherosclerosis
    Matthijs Moerland
    Department Cell Biology and Genetics Vascular Surgery, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 28:1277-82. 2008
    ..A transgenic mouse model was generated that allows conditional expression of human PLTP, based on the tetracycline-responsive gene system, to study the effects of an acute increase in plasma PLTP activity as may occur in inflammation...
  6. ncbi Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis
    Kevin D O'Brien
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Wash, USA
    Circulation 108:270-4. 2003
    b>Phospholipid transfer protein (PLTP) plays an important role in HDL particle metabolism and may modulate hepatic secretion of apolipoprotein B-containing lipoproteins...
  7. ncbi PLTP secreted by HepG2 cells resembles the high-activity PLTP form in human plasma
    Sarah Siggins
    National Public Health Institute, Department of Molecular Medicine, Biomedicum, P O Box 104, Fin 00251 Helsinki, Finland
    J Lipid Res 44:1698-704. 2003
    Plasma phospholipid transfer protein (PLTP) is an important regulator of plasma HDL levels and HDL particle distribution. PLTP is present in plasma in two forms, one with high and the other with low phospholipid transfer activity...
  8. ncbi Elevation of systemic PLTP, but not macrophage-PLTP, impairs macrophage reverse cholesterol transport in transgenic mice
    Hannelore Samyn
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Atherosclerosis 204:429-34. 2009
    b>Phospholipid transfer protein (PLTP) is a multifunctional protein synthesized by various cell types and secreted into the plasma. Plasma PLTP is able to transfer phospholipids between lipoproteins and modulate HDL particles...
  9. ncbi Reduction of HDL levels lowers plasma PLTP and affects its distribution among lipoproteins in mice
    Hannelore Samyn
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Biochim Biophys Acta 1791:790-6. 2009
    b>Phospholipid transfer protein (PLTP) is associated with HDL particles in plasma, where it transfers phospholipids between lipoproteins and remodels HDL particles...
  10. ncbi Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells
    Catherine M Desrumaux
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Lipid Res 44:1453-61. 2003
    b>Phospholipid transfer protein (PLTP) in plasma promotes phospholipid transfer from triglyceride-rich lipoproteins to HDL and plays a major role in HDL remodeling...
  11. ncbi Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I
    P J Pussinen
    National Public Health Institute, Department of Biochemistry, Helsinki, Finland
    J Lipid Res 39:152-61. 1998
    The interaction of plasma phospholipid transfer protein (PLTP) with HDL has not been characterized in detail, although we have reported that the apoA-I/apoA-II molar ratio in the HDL particle influences PLTP-mediated HDL conversion, but ..
  12. ncbi The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions
    Bryan A Laffitte
    Howard Hughes Medical Institute, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1662, USA
    Mol Cell Biol 23:2182-91. 2003
    ..Here we demonstrate that LXRs also regulate plasma lipoprotein metabolism through control of the phospholipid transfer protein (PLTP) gene...
  13. ncbi Phospholipid transfer protein: full-length cDNA and amino acid sequence in maize. Amino acid sequence homologies between plant phospholipid transfer proteins
    F Tchang
    Laboratoire de Physiologie Cellulaire, UA 1180 Centre National de la Recherche Scientifique, Universite P et M Curie, Paris, France
    J Biol Chem 263:16849-55. 1988
    We have determined the primary structure of a phospholipid transfer protein (PLTP) isolated from maize seeds. This protein consists of 93 amino acids and shows internal homology originating in the repetition of (do)decapeptides...
  14. ncbi Oxidative modification of HDL3 in vitro and its effect on PLTP-mediated phospholipid transfer
    J Huuskonen
    Department of Biochemistry, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Biochim Biophys Acta 1391:181-92. 1998
    ..and its effect on the ability of these particles to act as phospholipid acceptors in human plasma phospholipid transfer protein (PLTP)-mediated lipid transfer were investigated...
  15. ncbi Dose-dependent action of atorvastatin in type IIB hyperlipidemia: preferential and progressive reduction of atherogenic apoB-containing lipoprotein subclasses (VLDL-2, IDL, small dense LDL) and stimulation of cellular cholesterol efflux
    Maryse Guerin
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 551, Hopital de la Pitie, Pavillon Benjamin Delessert, 83 Boulevard de l hopital, 75651 Paris, Cedex 13, France
    Atherosclerosis 163:287-96. 2002
    ..063 g/ml), on CETP-mediated cholesteryl ester transfer from HDL to apoB-containing lipoproteins, on phospholipid transfer protein activity and on plasma-mediated cellular cholesterol efflux in patients (n=10) displaying type IIB ..
  16. ncbi Cloning and expression in phospholipid containing cultures of the gene encoding the specific phosphatidylglycerol/phosphatidylinositol transfer protein from Aspergillus oryzae: evidence that the pg/pi-tp is tandemly arranged with the putative 3-ketoacyl-C
    E Record
    Laboratoire de Biotechnologie des Champignons Filamenteux, INRA, CESB ESIL, Faculte des Sciences de Luminy, Parc Scientifique et Technologique, Case Postale 925, 13288 Marseille 09, Cedex, France
    Gene 262:61-72. 2001
    The phosphatidylglycerol/phosphatidylinositol transfer protein (PG/PI-TP) is a new and original phospholipid transfer protein (PLTP) isolated from the Deuteromycete, Aspergillus oryzae. We have isolated a genomic clone of the A...
  17. ncbi Phospholipid transfer protein gene knock-out mice have low high density lipoprotein levels, due to hypercatabolism, and accumulate apoA-IV-rich lamellar lipoproteins
    S Qin
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York NY 10032, USA
    J Lipid Res 41:269-76. 2000
    b>Phospholipid transfer protein gene knock-out (Pltp KO) mice have defective transfer of very low density lipoprotein (VLDL) phospholipids into high density lipoprotein (HDL) and markedly decreased HDL levels (Jiang et al. 1999. J. Clin...
  18. ncbi Deletions of helices 2 and 3 of human apoA-I are associated with severe dyslipidemia following adenovirus-mediated gene transfer in apoA-I-deficient mice
    Angeliki Chroni
    Section of Molecular Genetics, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biochemistry 44:4108-17. 2005
    ..The phospholipid transfer protein (PLTP) activity of plasma containing the apoA-I[Delta(89-99)] mutant was decreased to 32% of the WT ..
  19. ncbi Macrophage phospholipid transfer protein deficiency and ApoE secretion: impact on mouse plasma cholesterol levels and atherosclerosis
    Ruijie Liu
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Arterioscler Thromb Vasc Biol 27:190-6. 2007
    ..We investigated the relationship between PLTP and apoE in macrophages and the atherogenic relevance in a mouse model...
  20. ncbi Twenty four hour insulin infusion impairs the ability of plasma from healthy subjects and Type 2 diabetic patients to promote cellular cholesterol efflux
    R P Dullaart
    Department of Endocrinology, State University Hospital Groningen, PO Box 30 001, 9700 R B Groningen, The Netherlands
    Atherosclerosis 157:49-56. 2001
    ..Exogenous hyperinsulinaemia may not only decrease HDL cholesterol, but also plasma phospholipid transfer protein (PLTP) activity...
  21. ncbi The nuclear receptors FXR and LXRalpha: potential targets for the development of drugs affecting lipid metabolism and neoplastic diseases
    E J Niesor
    Symphar, Innovative Pharmaceutical Research, 1290 Versoix, Geneva, Switzerland
    Curr Pharm Des 7:231-59. 2001
    ..The natural and synthetic FXR agonists trigger differentiation, inhibit cell proliferation and are potent inducers of apoptosis. The 1,1-bisphosphonate ester SR-45023A (Apomine) is presently being developed as an antineoplastic drug...
  22. ncbi Cellular cholesterol efflux to plasma from moderately hypercholesterolaemic type 1 diabetic patients is enhanced, and is unaffected by simvastatin treatment
    R De Vries
    Department of Endocrinology, University of Groningen and University Medical Center Groningen, P O Box 30 001, Groningen, 9700, The Netherlands
    Diabetologia 48:1105-13. 2005
    ..Cellular cholesterol efflux to plasma is important in reverse cholesterol transport and may be affected by simvastatin in type 1 diabetes mellitus...
  23. ncbi High-density lipoprotein (HDL) transport in the metabolic syndrome: application of a new model for HDL particle kinetics
    Juying Ji
    Lipoprotein Research Unit, School of Medicine and Pharmacology, Royal Perth Hospital, Box X2213 GPO, Perth, WA 6847, Australia
    J Clin Endocrinol Metab 91:973-9. 2006
    ....
  24. ncbi Alterations in lipoprotein homeostasis during human experimental endotoxemia and clinical sepsis
    Johannes H M Levels
    Department of Experimental Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Biochim Biophys Acta 1771:1429-38. 2007
    ..transfer protein (CETP) activities were seen, whereas positive correlations between plasma phospholipid transfer protein (PLTP) activity and acute phase markers such as CRP and LPS binding protein were observed...
  25. ncbi Introduction of the human PLTP transgene suppresses the atherogenic diet-induced increase in plasma phospholipid transfer activity in C57BL/6 mice
    A Y Tu
    Department of Medicine, University of Washington, Seattle 98103, USA
    Int J Clin Lab Res 29:14-21. 1999
    The human plasma phospholipid transfer protein (PLTP) has been shown to facilitate the transfer of phospholipids between lipoproteins and convert high-density lipoproteins into larger and smaller particles in vitro...
  26. ncbi Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E
    Xian Cheng Jiang
    Downstate Medical Center, State University of New York, New York, New York 11203, USA
    J Biol Chem 277:31850-6. 2002
    ..b>Phospholipid transfer protein (PLTP) promotes vitamin E removal from atherogenic lipoproteins in vitro, and PLTP deficiency has ..
  27. ncbi Lipoprotein lipase and hepatic lipase: their relationship with HDL subspecies Lp(A-I) and Lp(A-I,A-II)
    Marian C Cheung
    Department of Medicine, University of Washington, Seattle, WA 98103, USA
    J Lipid Res 44:1552-8. 2003
    ..50, P <or= 0.006). Similar studies were performed with phospholipid transfer protein (PLTP). Only total Lp(A-I) triglyceride in women (not men) (r = 0.71, P = 0...
  28. ncbi SAA and PLTP activity in plasma of periodontal patients before and after full-mouth tooth extraction
    S Vuletic
    Department of Medicine, University of Washington, Seattle, Washington 98109, United States
    Oral Dis 14:514-9. 2008
    To assess whether treatment of advanced periodontal disease affects plasma levels of serum amyloid A (SAA) and phospholipid transfer protein (PLTP) activity.
  29. ncbi Phospholipid transfer protein deficiency impairs apolipoprotein-B secretion from hepatocytes by stimulating a proteolytic pathway through a relative deficiency of vitamin E and an increase in intracellular oxidants
    Xian Cheng Jiang
    State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 280:18336-40. 2005
    Genetic deficiency of the plasma phospholipid transfer protein (PLTP) in mice unexpectedly causes a substantial impairment in liver secretion of apolipoprotein-B (apoB), the major protein of atherogenic lipoproteins...
  30. ncbi Alpha-tocopherol modulates phosphatidylserine externalization in erythrocytes: relevance in phospholipid transfer protein-deficient mice
    Alexis Klein
    INSERM U498, IFR100, Universite de Bourgogne, Dijon, France
    Arterioscler Thromb Vasc Biol 26:2160-7. 2006
    ..The aim of the present study was to assess the effect of alpha-tocopherol, the main vitamin E isomer on phosphatidylserine (PS) exposure at the surface of circulating erythrocytes, and to determine consequences on erythrocyte properties...
  31. ncbi Human plasma phospholipid transfer protein activity is decreased by acute hyperglycaemia: studies without and with hyperinsulinaemia in Type 1 diabetes mellitus
    P H N Oomen
    Department of Endocrinology, University Hospital Groningen, Groningen, The Netherlands
    Diabet Med 22:768-74. 2005
    Little is known about the regulation of phospholipid transfer protein (PLTP), that plays a key role in lipoprotein metabolism...
  32. ncbi Absence of endogenous phospholipid transfer protein impairs ABCA1-dependent efflux of cholesterol from macrophage foam cells
    Miriam Lee-Rueckert
    Wihuri Research Institute, Helsinki, Finland
    J Lipid Res 47:1725-32. 2006
    In vitro experiments have demonstrated that exogenous phospholipid transfer protein (PLTP), i.e. purified PLTP added to macrophage cultures, influences ABCA1-mediated cholesterol efflux from macrophages to HDL...
  33. ncbi Plasma phospholipid transfer protein activity in patients with low HDL and cardiovascular disease treated with simvastatin and niacin
    M C Cheung
    Division of Metabolism, Endocrinology, and Nutrition, University of Washington, School of Medicine, Seattle 98103, USA
    Biochim Biophys Acta 1537:117-24. 2001
    Plasma phospholipid transfer protein (PLTP) is an important modulator of high-density lipoprotein (HDL) metabolism, regulating its particle size, composition, and mass...
  34. ncbi Vitamin E transfer from lipid emulsions to plasma lipoproteins: mediation by multiple mechanisms
    M Hacquebard
    Universite Libre de Bruxelles, 1070, Brussels, Belgium
    Lipids 43:663-71. 2008
    ....
  35. ncbi Phospholipid transfer protein-deficient mice absorb less cholesterol
    Ruijie Liu
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Box 5, Brooklyn, NY 11203, USA
    Arterioscler Thromb Vasc Biol 27:2014-21. 2007
    b>Phospholipid transfer protein (PLTP) plays an important role in lipoprotein metabolism and atherosclerosis. PLTP gene knockout (KO) mice show significant reduction of plasma cholesterol levels...
  36. ncbi Increased cholesterol efflux from cultured fibroblasts to plasma from hypertriglyceridemic type 2 diabetic patients: roles of pre beta-HDL, phospholipid transfer protein and cholesterol esterification
    R De Vries
    Department of Endocrinology, University Medical Centre Groningen, University of Groningen, PO Box 30 001, Groningen, 9700 RB, The Netherlands
    Atherosclerosis 196:733-41. 2008
    ..plasma lipids, HDL cholesterol and phospholipids, plasma pre beta-HDL and pre beta-HDL formation, phospholipid transfer protein (PLTP) activity, plasma cholesterol esterification (EST) and cholesteryl ester transfer (CET) and the ..
  37. ncbi Altered phospholipid transfer protein gene expression and serum lipid profile by topotecan
    Rudel A Saunders
    Department of Medicine, The University of Toledo, College of Medicine, Toledo, OH, United States
    Biochem Pharmacol 80:362-9. 2010
    ..response to topotecan in the human hepatoma HepG2 cells and found a striking induction of the phospholipid transfer protein (PLTP) gene expression by topotecan...
  38. ncbi Macrophage phospholipid transfer protein contributes significantly to total plasma phospholipid transfer activity and its deficiency leads to diminished atherosclerotic lesion development
    Riikka Vikstedt
    National Public Health Institute, Department of Molecular Medicine, Biomedicum, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 27:578-86. 2007
    Systemic phospholipid transfer protein (PLTP) deficiency in mice is associated with a decreased susceptibility to atherosclerosis, whereas overexpression of human PLTP in mice increases atherosclerotic lesion development...
  39. ncbi Molecular characterization of rabbit phospholipid transfer protein: choroid plexus and ependyma synthesize high levels of phospholipid transfer protein
    Roland Gander
    Department of Medicine, University of Innsbruck, Austria
    J Lipid Res 43:636-45. 2002
    b>Phospholipid transfer protein (PLTP) plays an important role in plasma lipoprotein metabolism. However, PLTP is expressed in a wide range of tissues suggesting additional local functions...
  40. ncbi Molecular cloning and functional expression of cDNA encoding the pig plasma phospholipid transfer protein
    P J Pussinen
    Department of Biochemistry, National Public Health Institute, Helsinki, Finland
    J Lipid Res 38:1473-81. 1997
    ..of the phospholipid mass transfer in human plasma, the other half being accounted for by the plasma phospholipid transfer protein (PLTP). This makes the pig an ideal subject for the study of PLTP structure and function...
  41. ncbi The reverse cholesterol transport system as a potential mediator of luteolysis in the primate corpus luteum
    Randy L Bogan
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, West Campus, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Reproduction 139:163-76. 2010
    ..facilitating high-density lipoprotein formation (lecithin:cholesterol acyltransferase or LCAT; phospholipid transfer protein or PLTP)...
  42. ncbi Lipid transfer proteins: past, present and perspectives
    Eder C R Quintao
    Lipids Lab, LIM 10, Faculty of Medical Sciences, University of Sao Paulo, SP, Brazil
    Atherosclerosis 209:1-9. 2010
    ..Therefore, the biological roles of PLTP and CETP must be carefully monitored when investigating drugs that inhibit their activity in the prevention of atherosclerosis...
  43. ncbi LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size
    Hiroaki Okazaki
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 285:6801-10. 2010
    ..T0901317 increased mRNAs not only for enzymes of fatty acid and triglyceride synthesis, but also for phospholipid transfer protein (PLTP), which transfers phospholipids into nascent VLDL, allowing particle expansion...
  44. ncbi Apolipoprotein E highly correlates with AbetaPP- and tau-related markers in human cerebrospinal fluid
    Simona Vuletic
    Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington School of Medicine, Seattle, WA 98109, USA
    J Alzheimers Dis 15:409-17. 2008
    We assessed cerebrospinal fluid (CSF) levels of apolipoprotein E (apoE), phospholipid transfer protein (PLTP) activity, cholesterol, secreted amyloid-beta protein precursor alpha and beta (sAbetaPPalpha, sAbetaPPbeta), amyloid-beta ..
  45. ncbi Decreasing dietary fat saturation lowers HDL-cholesterol and increases hepatic HDL binding in hamsters
    A H Terpstra
    Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Br J Nutr 83:151-9. 2000
    ..Levels of phospholipid transfer protein (PLTP) tended to be higher with increasing fat saturation but this effect was not significant...
  46. ncbi Plasma lipid transfer proteins, high-density lipoproteins, and reverse cholesterol transport
    C Bruce
    Department of Medicine, Columbia University, New York, New York 10032, USA
    Annu Rev Nutr 18:297-330. 1998
    Cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP) are members of the lipid transfer/lipopolysaccharide binding protein gene family...
  47. ncbi Phospholipid transfer protein deficiency ameliorates diet-induced hypercholesterolemia and inflammation in mice
    Lorraine Shelly
    Department of Cardiovascular, Metabolic, and Endocrine Diseases, Pfizer Global Research Division, Pfizer, Inc, Groton, CT 06340, USA
    J Lipid Res 49:773-81. 2008
    b>Phospholipid transfer protein (PLTP) facilitates the transfer of phospholipids from triglyceride-rich lipoproteins into HDL. PLTP has been shown to be an important factor in lipoprotein metabolism and atherogenesis...
  48. ncbi [High-density lipoproteins (HDL) size and composition are modified in the rat by a diet supplemented with "Hass" avocado (Persea americana Miller)]
    Oscar Pérez Méndez
    Departamento de Fisiologia, INCICH
    Arch Cardiol Mex 77:17-24. 2007
    ..To determine the effects of dietary avocado on HDL structure and their associated enzyme, paraoxonase 1 (PON1)...
  49. ncbi Posterolateral thigh perforator varicosities in 12 patients: a normal deep venous system and successful treatment with ultrasound-guided sclerotherapy
    Pierre van Neer
    Department of Dermatology, Laurentius Hospital, Roermond, The Netherlands
    Dermatol Surg 32:1346-52; discussion 1351-2. 2006
    ..To determine whether in patients with posterolateral thigh perforator (PLTP) varicosities ultrasound-guided sclerotherapy (USGS) is successful and to determine any deep venous anomaly...
  50. ncbi Functional analysis of the transcriptional activity of the mouse phospholipid transfer protein gene
    A Y Tu
    Department of Medicine, Northwest Lipid Research Laboratories, University of Washington, 2121 N 35th Street, Seattle, WA 98103, USA
    Biochem Biophys Res Commun 287:921-6. 2001
    b>Phospholipid transfer protein (PLTP) plays an important role in the metabolism of plasma high density lipoprotein. The mouse gene encoding PLTP and its promoter region has been cloned in our laboratory...
  51. ncbi Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis
    Marcel Scheideler
    Institute for Genomics and Bioinformatics and Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria
    BMC Genomics 9:340. 2008
    ....
  52. ncbi Protective modulation of carotid atherosclerosis in hyperalphalipoproteinemic individuals
    F D Santiago
    Clinical Pathology Department, Medical School, University of Campinas, Campinas, SP, Brazil
    Int J Cardiovasc Imaging 26:27-34. 2010
    ....
  53. ncbi Mouse model of paraquat-poisoned lungs and its gene expression profile
    Masafumi Tomita
    Department of Medical Toxicology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Japan
    Toxicology 231:200-9. 2007
    ..These changes in gene expression, which are equalled to functional activities of proteins, will be the targets for future studies focused on the development on PQ-induced pulmonary damage...
  54. ncbi Human apoA-I/C-III/A-IV gene cluster transgenic rabbits: effects of a high-cholesterol diet
    Delia Recalde
    Unité d Expression des Gènes Eucaryotes, Institut Pasteur, Paris, France
    FEBS Lett 572:294-8. 2004
    ....
  55. ncbi European Lipoprotein Club: report of the 21st Annual Conference, Tutzing, September 28-October 1, 1998
    P Benlian
    Department of Biochemistry and Molecular Biology, Hopital Saint Antoine, Paris, France
    Atherosclerosis 144:449-58. 1999
    ....
  56. ncbi Plasma phospholipid transfer protein deficiency in mice is associated with a reduced thrombotic response to acute intravascular oxidative stress
    Catherine Desrumaux
    Institut National de la Sante et de la Recherche Medicale, UMR866, Dijon, France
    Arterioscler Thromb Vasc Biol 30:2452-7. 2010
    Earlier in vitro studies suggested a putative role for the plasma phospholipid transfer protein (PLTP) in the modulation of blood coagulation...
  57. ncbi Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease
    N Demeester
    Department of Biochemistry, University of Gent, B 9000 Gent, Belgium
    J Lipid Res 41:963-74. 2000
    ..CSF lipoproteins induced a significant cholesterol efflux from cultured rat astrocytes, suggesting that they play an active role in maintaining the cholesterol homeostasis in brain cells...
  58. ncbi Relation of baseline plasma phospholipid transfer protein (PLTP) activity to left ventricular systolic dysfunction in patients referred for coronary angiography
    Erdal Cavusoglu
    Department of Medicine, Division of Cardiology, SUNY Downstate Medical Center, Brooklyn, NY 11203 2098, United States
    Atherosclerosis 207:261-5. 2009
    b>Phospholipid transfer protein (PLTP) is an important modulator of phospholipid transfer and exchange among proteins. It also plays a role in inflammation and oxidative stress...
  59. ncbi Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol
    Sabine M Post
    TNO Quality of Life, Department of Biomedical Research, Gaubius Laboratory, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:2724-30. 2006
    ..We investigated the effect of Cyp7a1 deficiency on HDL metabolism in APOE*3-Leiden transgenic mice...
  60. ncbi Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo
    Nigora Mukhamedova
    BakerIDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    J Lipid Res 49:2312-22. 2008
    Eight proteins potentially involved in cholesterol efflux [ABCA1, ABCG1, CYP27A1, phospholipid transfer protein (PLTP), scavenger receptor type BI (SR-BI), caveolin-1, cholesteryl ester transfer protein, and apolipoprotein A-I (apoA-I)] ..
  61. ncbi Effect of plasma phospholipid transfer protein deficiency on lethal endotoxemia in mice
    Thomas Gautier
    INSERM, Centre de Recherche UMR866, Faculte de Medecine, Institut Fédératif de Recherche Santé STIC, Universitéde Bourgogne, 21079 Dijon, France
    J Biol Chem 283:18702-10. 2008
    ..In addition to LBP, the lipid transfer/lipopolysaccharide-binding protein gene family includes the phospholipid transfer protein (PLTP)...
  62. ncbi Phospholipid transfer protein deficiency reduces sperm motility and impairs fertility of mouse males
    Véronique Drouineaud
    Laboratoire de Biologie de la Reproduction, EA Génétique et Reproduction 3185, CHU Dijon, Dijon, France
    FASEB J 20:794-6. 2006
    ..biology, and its transport in mammalian plasma and brain was shown to be governed by plasma phospholipid transfer protein (PLTP)...
  63. ncbi Characterization of the mouse gene encoding phospholipid transfer protein
    A Y Tu
    Department of Medicine, University of Washington, Seattle 98103, USA
    Gene 188:115-8. 1997
    The mouse gene encoding phospholipid transfer protein (PLTP) was cloned from 129/SvJ lambdaFIX(R) II library and characterized for the first time. It is comprised of 16 exons separated by 15 introns...
  64. ncbi Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists
    Véronique Drouineaud
    Laboratoire de Biologie de la Reproduction, CECOS Franche Comté Bourgogne EA Génétique et Reproduction 3185, CHU Dijon, Dijon, France
    Mol Hum Reprod 13:373-9. 2007
    ..Our study identifies LXRs as new, key actors contributing to regulation of cholesterol metabolism and steroidogenesis in luteinized granulosa cells...
  65. ncbi Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins
    C J Kirschning
    Molecular Sepesis Research Laboratory, Max Delbrück Center for Molecular Medicine MDC, University Hospital Charite, Humboldt University, Berlin, Germany
    Genomics 46:416-25. 1997
    ..This high degree of similarity supports functional studies by others suggesting that like LBP, PLTP may also be able to bind and transport bacterial lipopolysaccharide...
  66. ncbi Cholesterol accumulation is increased in macrophages of phospholipid transfer protein-deficient mice: normalization by dietary alpha-tocopherol supplementation
    Nicolas Ogier
    INSERM U866, Centre de Recherche, IFR Santé STIC, Faculte de Medecine, Universite de Bourgogne, Dijon, France
    Arterioscler Thromb Vasc Biol 27:2407-12. 2007
    b>Phospholipid transfer protein (PLTP) is a multifunctional, extracellular lipid transport protein that plays a major role in lipoprotein metabolism and atherosclerosis...
  67. ncbi Genetic variation in phospholipid transfer protein modulates lipoprotein profiles in hyperalphalipoproteinemia
    Mary B Engler
    Department of Physiological Nursing, University of California San Francisco, San Francisco, CA 94143, USA
    Metabolism 57:1719-24. 2008
    We previously demonstrated the role of a phospholipid transfer protein (PLTP) gene variation (rs2294213) in determining levels of high-density lipoprotein cholesterol (HDL-C) in hypoalphalipoproteinemia (HypoA)...
  68. ncbi PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice
    Willeke de Haan
    Department of General Internal Medicine, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Biochim Biophys Acta 1791:191-7. 2009
    ..We conclude that chronic PXR agonism dose-dependently reduces plasma HDL-cholesterol in the presence of CETP...
  69. ncbi Macrophage cholesterol efflux to plasma and HDL in subjects with low and high homocysteine levels: a FIELD substudy
    Marianna Maranghi
    Helsinki University Central Hospital, Biomedicum, Haartmaninkatu 8 PO Box 700, FIN 00029 Helsinki, Finland
    Atherosclerosis 219:259-65. 2011
    ..plasma or HDL to facilitate cholesterol efflux from THP-1 foam cells; (2) plasma potential to generate pre?-HDL; (3) plasma phospholipid transfer protein (PLTP) activity, serum PON-1 mass and activity, HDL particle size and distribution.
  70. ncbi The role of phospholipid transfer protein in lipoprotein-mediated neutralization of the procoagulant effect of anionic liposomes
    C Oslakovic
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
    J Thromb Haemost 8:766-72. 2010
    ..b>Phospholipid transfer protein (PLTP) mediates transfer of PLs between HDL and other lipoproteins and conversion of HDL into larger ..
  71. ncbi Increased biglycan in aortic valve stenosis leads to the overexpression of phospholipid transfer protein via Toll-like receptor 2
    Habib Derbali
    Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725 Chemin Ste Foy Québec, Quebec, Canada, G1V 4G5
    Am J Pathol 176:2638-45. 2010
    ..The microarray results indicated that only biglycan (BGN) and phospholipid transfer protein (PLTP) were overexpressed in the AS valves. These results were then confirmed by quantitative PCR...
  72. ncbi Innate immune response triggered by triacyl lipid A is dependent on phospholipid transfer protein (PLTP) gene expression
    Thomas Gautier
    Centre de Recherche INSERM UMR866, Universite de Bourgogne, Faculte de Medecine, 7 Boulevard Jeanne d Arc, BP87900, 21079 Dijon Cedex, France
    FASEB J 24:3544-54. 2010
    ..Because plasma phospholipid transfer protein (PLTP) transfers hexaacyl LPS, its impact on metabolism and biological activity of triacyl lipid A in ..
  73. ncbi Human apoA-I increases macrophage foam cell derived PLTP activity without affecting the PLTP mass
    Marius R Robciuc
    National Institute for Health and Welfare, Public Health Genomics Research Unit and FIMM, Institute for Molecular Medicine Finland, Helsinki, Finland
    Lipids Health Dis 9:59. 2010
    b>phospholipid transfer protein (PLTP) plays important roles in lipoprotein metabolism and atherosclerosis and is expressed by macrophages and macrophage foam cells (MFCs)...
  74. ncbi CpG array analysis of histone H3 lysine 4 trimethylation in peripheral blood mononuclear cells of uremia patients
    Li Zhang
    Department of Nephrology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China
    DNA Cell Biol 30:179-86. 2011
    ..Such novel findings show the significance of H3K4me3 as a potential biomarker or promising target for epigenetic-based uremia therapies...
  75. ncbi Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project
    Guillaume Lettre
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1001300. 2011
    ..Our project has developed resources and methods that address both admixture- and SNP-association to maximize power for genetic discovery in even larger African-American consortia...
  76. ncbi Plasma phospholipid transfer protein activity is independently determined by obesity and insulin resistance in non-diabetic subjects
    Rindert de Vries
    Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Atherosclerosis 217:253-9. 2011
    b>Phospholipid transfer protein (PLTP) is an emerging cardio-metabolic risk factor which is intricately involved in lipoprotein metabolism...
  77. ncbi Genetic and nongenetic sources of variation in phospholipid transfer protein activity
    Gail P Jarvik
    Department of Medicine Division of Medical Genetics, University of Washington, Seattle, WA, USA
    J Lipid Res 51:983-90. 2010
    b>Phospholipid transfer protein (PLTP) belongs to the lipid transfer/lipopolysaccharide-binding protein gene family. Expression of PLTP has been implicated in the development of atherosclerosis...
  78. ncbi Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice
    Constance Schmelzer
    Institute of Human Nutrition and Food Science, Molecular Prevention, Christian Albrechts University of Kiel, Heinrich Hecht Platz 10, Kiel, Germany
    Mol Nutr Food Res 54:805-15. 2010
    ..These data may explain, at least in part, the decelerating effects on degenerative processes observed in Q(10)H(2)-supplemented SAMP1 mice...
  79. ncbi Human plasma phospholipid transfer protein specific activity is correlated with HDL size: implications for lipoprotein physiology
    Marian C Cheung
    Department of Medicine, University of Washington, Seattle, WA 98109 4517, USA
    Biochim Biophys Acta 1791:206-11. 2009
    To gain further insights into the relationship between plasma phospholipid transfer protein (PLTP) and lipoprotein particles, PLTP mass and phospholipid transfer activity were measured, and their associations with the level and size of ..
  80. ncbi Plasma phospholipid transfer protein, cholesteryl ester transfer protein and lecithin:cholesterol acyltransferase in end-stage renal disease (ESRD)
    Madeleine V Pahl
    Division of Nephrology and Hypertension, University of California, Irvine, CA, USA
    Nephrol Dial Transplant 24:2541-6. 2009
    ..Several plasma proteins including phospholipid transfer protein (PTLP), cholesteryl ester transfer protein (CETP) and lecithin:cholesterol acyltransferase (LCAT) ..
  81. ncbi Plasma pre beta-HDL formation is decreased by atorvastatin treatment in type 2 diabetes mellitus: Role of phospholipid transfer protein
    G M Dallinga-Thie
    Academic Medical Center Amsterdam, The Netherlands
    Biochim Biophys Acta 1791:714-8. 2009
    Atorvastatin lowers plasma phospholipid transfer protein (PLTP) activity, which stimulates pre-beta-HDL generation in vitro...
  82. ncbi Phospholipid transfer protein reduces phosphorylation of tau in human neuronal cells
    Weijiang Dong
    Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington School of Medicine, Seattle, Washington 98109, USA
    J Neurosci Res 87:3176-85. 2009
    ..In this study we provide evidence that phospholipid transfer protein (PLTP), one of the main lipid transfer proteins in the brain, significantly reduces levels of ..
  83. ncbi Novel roles of hepatic lipase and phospholipid transfer protein in VLDL as well as HDL metabolism
    Rien van Haperen
    Department of Cell Biology and Genetics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Biochim Biophys Acta 1791:1031-6. 2009
    Elevated plasma phospholipid transfer protein (PLTP) expression may increase atherosclerosis in mice by reducing plasma HDL and increasing hepatic VLDL secretion...
  84. ncbi Haptoglobin inhibits phospholipid transfer protein activity in hyperlipidemic human plasma
    Ryan J Henderson
    Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia V6T1Z3, Canada
    Lipids Health Dis 8:27. 2009
    Haptoglobin is a plasma protein that scavenges haemoglobin during haemolysis. Phospholipid Transfer Protein (PLTP) transfers lipids from Low Density Lipoproteins (LDL) to High Density Lipoproteins (HDL)...
  85. ncbi Plasma PLTP activity is inversely associated with HDL-C levels
    Xueying Chen
    Institute of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, PR China
    Nutr Metab (Lond) 6:49. 2009
    ABSTRACT: Phospholipid transfer protein (PLTP) is an important modulator of lipoprotein metabolism, including interparticle phospholipid transfer, remodeling of HDL, cholesterol and phospholipid efflux from peripheral tissues, and the ..
  86. ncbi Dry eye symptoms are increased in mice deficient in phospholipid transfer protein (PLTP)
    Niko L Setälä
    Department of Ophthalmology, University of Helsinki, Helsinki, Finland
    Am J Pathol 178:2058-65. 2011
    ..b>Phospholipid transfer protein (PLTP) mediates phospholipid transfer processes between serum lipoproteins and is also a normal ..
  87. ncbi Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency
    X C Jiang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA
    Nat Med 7:847-52. 2001
    ..The studies reveal a major, unexpected role of PLTP in regulating the secretion of BLp and identify PLTP as a therapeutic target...
  88. ncbi Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1
    Omar L Francone
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Biochemistry 42:8569-78. 2003
    ..Plasma phospholipid transfer protein (PLTP) and lecithin cholesterol acyltransferase (LCAT) activities were decreased by more than 80%, ..
  89. ncbi Plasma phospholipid transfer protein-mediated reactions are impaired by hypochlorite-modification of high density lipoprotein
    Pirkko J Pussinen
    Institute of Dentistry, University of Helsinki, P O Box 63, FIN 00014, Helsinki, Finland
    Int J Biochem Cell Biol 35:192-202. 2003
    The two main functions of phospholipid transfer protein (PLTP) are the transfer of phospholipids between plasma lipoproteins and the conversion of high density lipoprotein (HDL), where prebeta-HDL particles are generated...
  90. ncbi Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors
    Alfredo Morabia
    Division of Clinical Epidemiology, Geneva University Hospitals, Switzerland
    Hum Mol Genet 12:2733-43. 2003
    ..We propose a model involving these 14 genetic and non-genetic risk factors for evaluation in future independent studies...
  91. ncbi Periodontitis decreases the antiatherogenic potency of high density lipoprotein
    Pirkko J Pussinen
    Institute of Dentistry, University of Helsinki, Finland
    J Lipid Res 45:139-47. 2004
    ..7), HDL composition, and key proteins of HDL metabolism were determined. After periodontal treatment, phospholipid transfer protein (PLTP) activity was 6.2% (P<0...
  92. ncbi Early differential gene expression of rat lung after exposure to paraquat
    Masafumi Tomita
    Department of Medical Toxicology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
    Free Radic Res 38:821-9. 2004
    ..Four clones were finally determined to be significantly affected. These genes were mRNAs for plasma phospholipid transfer protein (PLTP), CL1BA protein, (latrophilin: LPH), and alphaII-spectrin as well as one unknown gene...
  93. ncbi Lipid transfer protein activities in type 1 diabetic patients without renal failure and nondiabetic control subjects and their association with coronary artery calcification
    H M Colhoun
    Royal Free and University College London Medical School, UK
    Diabetes 50:652-9. 2001
    ..the role of cholesteryl ester transfer (CET), cholesteryl ester transfer protein (CETP) activity, and phospholipid transfer protein (PLTP) activity in the increased prevalence of coronary artery calcification (CAC) in diabetic ..
  94. ncbi Remodeling of HDL remnants generated by scavenger receptor class B type I
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY, USA
    J Lipid Res 45:1666-73. 2004
    ..HDL remnant conversion is not altered in phospholipid transfer protein (PLTP)-deficient mouse plasma or by the addition of purified PLTP...
  95. ncbi Anti-inflammatory effects of phospholipid transfer protein (PLTP) deficiency in mice
    Axel Schlitt
    Department of Anatomy and Cell Biology, State University of New York, Downstate Medical Center, Brooklyn, 11203, USA
    Biochim Biophys Acta 1733:187-91. 2005
    We previously reported that phospholipid transfer protein-deficient (PLTP KO) mice exhibit a lower rate of atherosclerosis...
  96. ncbi Phospholipid transfer protein (PLTP) mRNA expression is stimulated by developing embryos in the oviduct
    Kai Fai Lee
    Department of Obstetrics and Gynaecology, The University of Hong Kong, Pokfulam, Hong Kong, Peoples Republic of China
    J Cell Biochem 95:740-9. 2005
    ..This molecule would be a target to delineate the mechanisms and the roles of oviductal secretory proteins on early embryonic development...
  97. ncbi Plasma phospholipid transfer protein activity and subclinical inflammation in type 2 diabetes mellitus
    K C B Tan
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokufulam Road, Hong Kong, Hong Kong
    Atherosclerosis 178:365-70. 2005
    b>Phospholipid transfer protein (PLTP) transfers phospholipids between lipoproteins, and plays an essential role in HDL metabolism...
  98. ncbi Acute-phase HDL in phospholipid transfer protein (PLTP)-mediated HDL conversion
    P J Pussinen
    National Public Health Institute, Department of Biochemistry, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Atherosclerosis 155:297-305. 2001
    In reverse cholesterol transport, plasma phospholipid transfer protein (PLTP) converts high density lipoprotein(3) (HDL(3)) into two new subpopulations, HDL(2)-like particles and prebeta-HDL...
  99. ncbi PLTP activity decreases with weight loss: changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity
    Susan J Murdoch
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 44:1705-12. 2003
    b>Phospholipid transfer protein (PLTP) activity is elevated in obese and diabetic subjects...
  100. ncbi Increased fecal bile acid excretion in transgenic mice with elevated expression of human phospholipid transfer protein
    Sabine M Post
    Gaubius Laboratory, TNO Prevention and Health, PO Box 2215, 2301 CE, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 23:892-7. 2003
    ..b>Phospholipid transfer protein (PLTP) promotes the transfer of phospholipids between lipoproteins and modulates HDL size and ..

Research Grants62

  1. FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORS
    Sergio Fazio; Fiscal Year: 2009
    ..We have discovered a functional connection between two proteins (apoE and LRP1) that improves cholesterol disposal in plaque macrophages, and may lead to development of new drugs for regression of coronary plaques. ..
  2. Molecular and Funcitonal Analysis of Human A-I
    Vassilis I Zannis; Fiscal Year: 2010
    ..This information is important in the design of new pharmaceuticals to increase HDL levels while preserving the atheroprotective functions of HDL and thus decrease the risk for cardiovascular disease. ..
  3. FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORS
    Sergio Fazio; Fiscal Year: 2010
    ..We have discovered a functional connection between two proteins (apoE and LRP1) that improves cholesterol disposal in plaque macrophages, and may lead to development of new drugs for regression of coronary plaques. ..
  4. IMMUNOCHEMICAL STRUCTURE/FUNCTION OF APOLIPOPROTEIN A-I
    Linda Curtiss; Fiscal Year: 2007
    ..The first aim will identify the role of phospholipid transfer protein (PLTP) in the generation of lipid-poor apoAI in vivo and in vitro...
  5. PROTEINS OF COAGULATION PATHWAYS
    John H Griffin; Fiscal Year: 2010
    ..For aim 2, we hypothesize that plasma phospholipid transfer protein (PLTP) can directly influence plasma coagulability and thrombin generation by novel direct ..
  6. MECHANISM OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 1993
    ..These studies will provide the first systematic test of the most explicit model of neuronal information storage yet proposed. The information acquired may well be relevant to the general questions of memory storage...
  7. ENZYMATIC REACTIONS OF PLASMA LIPOPROTEINS
    HENRY POWNALL; Fiscal Year: 2000
    ..which include cholesteryl ester transfer protein (CETP), lecithin:cholesterol acyltransferase (LCAT), phospholipid transfer protein (PLTP), and hepatic lipase (HL)...
  8. Molecular Mechanisms of Biogenesis of Apolipoprotein B-Containing Lipoproteins
    Nassrin Dashti; Fiscal Year: 2009
    ..2) The initial lipid transfer to the lipid pocket is mediated by phospholipid transfer protein (PLTP)...
  9. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009
    ..of EL and HL with the lipid transfer proteins cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP), the implications and mechanisms of upregulation of EL activity in the obese insulin resistant ..
  10. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009
    ..of EL and HL with the lipid transfer proteins cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP), the implications and mechanisms of upregulation of EL activity in the obese insulin resistant ..
  11. LIPID TRANSFER MECHANISMS
    HENRY POWNALL; Fiscal Year: 2005
    ..A phospholipid transfer protein (PLTP) in human plasma is a key protein in the remodeling of HDL...
  12. High-Density Lipoprotein Species--Structures and Roles
    John Kane; Fiscal Year: 2005
    ..3) To characterize the HDL species that are substrates and products of SR-Bl, -hepatic lipase (HL), -phospholipid transfer protein (PLTP), and - mediated reactions...
  13. RETINOID SIGNALING BY A NEW NUCLEAR HORMONE RECEPTOR
    David Moore; Fiscal Year: 2002
    ..4) ES cell lines defective in the RIP14 gene will be generated and used to create mice deficient in RIP14. ..
  14. CELLULAR DISORDERS IN FAMILIAL HDL DEFICIENCIES
    John Oram; Fiscal Year: 2003
    ..These studies will help design therapeutic approaches for correcting cellular disorders associated with low plasma HDL and increased risk for heart disease. ..
  15. Anti-inflammatory, cholesterol export, and cardioprotective functions of ABCA1
    John Oram; Fiscal Year: 2009
    ..This research will investigate the cell pathways involved in the cholesterol removal and anti-inflammatory actions of ABCA1 and determine if these pathways protect against heart disease in animals. ..
  16. Atherogenic Effects of Oxidized High Density Lipoproteins
    John Oram; Fiscal Year: 2006
    ....
  17. Modulation of ABCA1 Expression and Activity
    John Oram; Fiscal Year: 2007
    ..These studies will suggest possible sites of impairment of the ABCA1 pathway and uncover potential therapeutic targets for treating cardiovascular disease. ..