phospholamban

Summary

Gene Symbol: phospholamban
Description: phospholamban
Alias: CMD1P, CMH18, PLB, cardiac phospholamban
Species: human

Top Publications

  1. ncbi Common variants at ten loci influence QT interval duration in the QTGEN Study
    Christopher Newton-Cheh
    Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Nat Genet 41:399-406. 2009
  2. ncbi Common variants at ten loci modulate the QT interval duration in the QTSCD Study
    Arne Pfeufer
    Institute of Human Genetics, Helmholtz Center Munich, Germany
    Nat Genet 41:407-14. 2009
  3. ncbi A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids
    Kobra Haghighi
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0575, USA
    Hum Mutat 29:640-7. 2008
  4. ncbi Phospholamban R14 deletion results in late-onset, mild, hereditary dilated cardiomyopathy
    Megan M DeWitt
    Department to Medicine, Section of Cardiology, The University of Chicago, Chicago, Illinois, USA
    J Am Coll Cardiol 48:1396-8. 2006
  5. ncbi A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy
    Kobra Haghighi
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 103:1388-93. 2006
  6. ncbi Genetic deletion of arginine 14 in phospholamban causes dilated cardiomyopathy with attenuated electrocardiographic R amplitudes
    Maximilian G Posch
    Experimental and Clinical Research Center ECRC, Berlin, Germany
    Heart Rhythm 6:480-6. 2009
  7. ncbi Mutational screening of phospholamban gene in hypertrophic and idiopathic dilated cardiomyopathy and functional study of the PLN -42 C>G mutation
    Maria Medin
    Hospital Universitario Juan Canalejo, Spain
    Eur J Heart Fail 9:37-43. 2007
  8. ncbi Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs)
    Michio Asahi
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    J Biol Chem 277:26725-8. 2002
  9. ncbi Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human
    Kobra Haghighi
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Invest 111:869-76. 2003
  10. ncbi Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban
    Joachim P Schmitt
    Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 299:1410-3. 2003

Research Grants

  1. Characterizing autoimmunity in NOD mouse islets, PLN and spleen
    Daniel Kaufman; Fiscal Year: 2007
  2. Cardiac Sarcoplasmic Reticulum Calcium Cycling Proteins
    Evangelia G Kranias; Fiscal Year: 2010
  3. Calcium Handling in Cardiac Pathophysiology
    Evangelia Kranias; Fiscal Year: 2009
  4. Calcium Handling in Cardiac Pathophysiology
    Evangelia G Kranias; Fiscal Year: 2010
  5. Mechanisms regulating SR Ca2+ ATPase in the Atria
    Muthu Periasamy; Fiscal Year: 2010
  6. AKAP Regulation of PKA Targeting in the Heart
    Meredith Bond; Fiscal Year: 2009
  7. Phospholemman and Na-Pump Function in Cardiac Myocytes
    Donald M Bers; Fiscal Year: 2010
  8. Troponin and Heart Function in Health and Disease
    JOSEPH MARK METZGER; Fiscal Year: 2010
  9. NMR Structural Analysis of Calcium Regulation in Muscle
    Gianluigi Veglia; Fiscal Year: 2010
  10. RECEPTOR TOPOGRAPHY IN MICROVASCULAR LEUKOCYTE ADHESION
    Ulrich von Andrian; Fiscal Year: 2005

Detail Information

Publications158 found, 100 shown here

  1. ncbi Common variants at ten loci influence QT interval duration in the QTGEN Study
    Christopher Newton-Cheh
    Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Nat Genet 41:399-406. 2009
    ..5% of the variation in QT interval. These results, together with an accompanying paper, offer insights into myocardial repolarization and suggest candidate genes that could predispose to sudden cardiac death and drug-induced arrhythmias...
  2. ncbi Common variants at ten loci modulate the QT interval duration in the QTSCD Study
    Arne Pfeufer
    Institute of Human Genetics, Helmholtz Center Munich, Germany
    Nat Genet 41:407-14. 2009
    ..These results, together with an accompanying paper from the QTGEN consortium, identify new candidate genes for ventricular arrhythmias and SCD...
  3. ncbi A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids
    Kobra Haghighi
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0575, USA
    Hum Mutat 29:640-7. 2008
    Depressed calcium handling by the sarcoplasmic reticulum (SR) Ca-ATPase and its regulator phospholamban (PLN) is a key characteristic of human and experimental heart failure...
  4. ncbi Phospholamban R14 deletion results in late-onset, mild, hereditary dilated cardiomyopathy
    Megan M DeWitt
    Department to Medicine, Section of Cardiology, The University of Chicago, Chicago, Illinois, USA
    J Am Coll Cardiol 48:1396-8. 2006
    The purpose of this research was to determine the phenotypic spectrum associated with phospholamban gene (PLN) mutations.
  5. ncbi A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy
    Kobra Haghighi
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 103:1388-93. 2006
    ..we identified a previously uncharacterized deletion of arginine 14 (PLN-R14Del) in the coding region of the phospholamban (PLN) gene in a large family with hereditary heart failure. No homozygous individuals were identified...
  6. ncbi Genetic deletion of arginine 14 in phospholamban causes dilated cardiomyopathy with attenuated electrocardiographic R amplitudes
    Maximilian G Posch
    Experimental and Clinical Research Center ECRC, Berlin, Germany
    Heart Rhythm 6:480-6. 2009
    ..Thus, identification of disease-causing mutations is a challenging and time-consuming task. Genotype-phenotype associations may alleviate identification of the underlying mutation...
  7. ncbi Mutational screening of phospholamban gene in hypertrophic and idiopathic dilated cardiomyopathy and functional study of the PLN -42 C>G mutation
    Maria Medin
    Hospital Universitario Juan Canalejo, Spain
    Eur J Heart Fail 9:37-43. 2007
    b>Phospholamban is an endogenous sarcoplasmic reticulum calcium ATPase inhibitor with a regulatory effect on cardiac contraction/relaxation coupling...
  8. ncbi Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs)
    Michio Asahi
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    J Biol Chem 277:26725-8. 2002
    ..of fast-twitch skeletal muscle (SERCA1a), is also expressed in cardiac and slow-twitch skeletal muscles where phospholamban (PLN) and SERCA2a are expressed...
  9. ncbi Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human
    Kobra Haghighi
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Invest 111:869-76. 2003
    ..In mice, disruption of the PLN gene encoding phospholamban (PLN) or expression of dominant-negative PLN mutants enhances SR and cardiac function, but effects of PLN ..
  10. ncbi Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban
    Joachim P Schmitt
    Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 299:1410-3. 2003
    ..congestive heart failure is caused by a dominant Arg --> Cys missense mutation at residue 9 (R9C) in phospholamban (PLN), a transmembrane phosphoprotein that inhibits the cardiac sarcoplasmic reticular Ca2+-adenosine ..
  11. ncbi Sarcolipin regulates sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholamban
    Michio Asahi
    Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, Canada M5G 1L6
    Proc Natl Acad Sci U S A 100:5040-5. 2003
    b>Phospholamban (PLN), a regulator of sarco(endo)plasmic reticulum Ca(2+)-ATPases (SERCAs), interacts with both the cytosolic N domain and transmembrane helices M2, M4, M6, and M9 of SERCA...
  12. ncbi Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy
    Susumu Minamisawa
    Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666, Tokyo, Japan
    Biochem Biophys Res Commun 304:1-4. 2003
    b>Phospholamban is an endogenous inhibitor of sarcoplasmic reticulum calcium ATPase and plays a prime role in cardiac contractility and relaxation. Phospholamban may be a candidate gene responsible for cardiomyopathy...
  13. ncbi Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy
    Christine Chiu
    Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, Sydney Australia
    J Mol Cell Cardiol 43:337-43. 2007
    ..for mutations in the Ca(2+) regulatory genes, sorcin (SRI), calstabin (FKBP1B), calsequestrin (CASQ2), phospholamban (PLN), sarcolipin (SLN), calreticulin (CALR3) and calmodulin (CALM)...
  14. ncbi Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease
    Michele Rossini
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Kidney Int 68:2621-8. 2005
    ....
  15. ncbi Kinetic analysis of covalent hybrid plasminogen activators: effect of CNBr-degraded fibrinogen on kinetic parameters of Glu1-plasminogen activation
    P P Lee
    Department of Medicine, University of Chicago Medical Center/Michael Reese Hospital and Medical Center, Pritzker School of Medicine, University of Chicago, Illinois 60616
    Biochemistry 27:7506-13. 1988
    ..CNBr-Fg enhanced significantly the activities of only two activators, t-PA and PlnA-t-PAB...
  16. ncbi Activation of CD4+ and CD8+ lymphocyte subsets by streptozotocin in the popliteal lymph node assay. II. Comparison with acute graft-vs-host reaction in H-2 incompatible F1 mouse hybrids
    K Krzystyniak
    Laboratoire d'Immunotoxicologie, INSERM U80, , Lyon, France
    Immunopharmacol Immunotoxicol 14:865-82. 1992
    ..abstract truncated at 400 words)..
  17. ncbi Purification and characterization of secretory phospholipase B, lysophospholipase and lysophospholipase/transacylase from a virulent strain of the pathogenic fungus Cryptococcus neoformans
    S C Chen
    Centre for Infectious Diseases and Microbiology, University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia
    Biochem J 347:431-9. 2000
    ..A highly active extracellular phospholipase, demonstrating phospholipase B (PLB), lysophospholipase (LPL) and lysophospholipase/transacylase (LPTA) activities, was purified to homogeneity from C...
  18. ncbi Reduced sarcoplasmic reticulum Ca2+ uptake and increased Na+-Ca2+ exchanger expression in left ventricle myocardium of dogs with progression of heart failure
    Sudhish Mishra
    Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI 48202, USA
    Heart Vessels 20:23-32. 2005
    ..These regulatory proteins include Ca(2+)-ATPase (SERCA 2A), phospholamban (PLB), ryanodine-sensitive Ca(2+) release channels (RR), and the sarcolemmal Na(+)-Ca(2+) exchanger (NCX)...
  19. ncbi Differential expression of homing receptors and vascular addressins in tonsils and draining lymph nodes: Effect of Brucella infection in sheep
    Vanessa Suraud
    UR 1282, Unité d Infectiologie Animale et Santé Publique, Institut National de Recherche Agronomique, Centre de Tours Nouzilly, F 37380 Nouzilly, France
    Vet Immunol Immunopathol 115:239-50. 2007
    ....
  20. ncbi Immunomodulatory effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin tested by the popliteal lymph node assay
    F Fan
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Toxicol Pathol 23:513-7. 1995
    ..Results also suggest that drugs may be useful surrogates to study the mechanism of toxicity of environmental chemicals that cannot be administered to humans...
  21. ncbi Phosphorylation of phospholamban by cAMP-dependent protein kinase enhances interactions between Ca-ATPase polypeptide chains in cardiac sarcoplasmic reticulum membranes
    S Negash
    Department of Biochemistry, University of Kansas, Lawrence 66045 2106, USA
    Biochemistry 35:11247-59. 1996
    ..accompany the activation of the cardiac sarcoplasmic reticulum (SR) Ca-ATPase following the phosphorylation of phospholamban (PLB)...
  22. ncbi Frequency-dependent acceleration of relaxation in mammalian heart: a property not relying on phospholamban and SERCA2a phosphorylation
    Carlos A Valverde
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, 60 y 120, 1900 La Plata, Argentina
    J Physiol 562:801-13. 2005
    ..is the Ca(2+)-calmodulin-dependent protein kinase (CaMKII)-dependent phosphorylation of the Thr(17) site of phospholamban (PLN)...
  23. ncbi Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast
    Clive P Morgan
    Department of Physiology, Rockefeller Building, University College London, University St, London WC1E 6JJ, UK
    Biochem J 382:441-9. 2004
    ..14, 253-257]. We assayed Dictyostelium lysates to demonstrate the presence of a highly active phospholipase B (PLB) enzyme that removed both fatty-acid chains from phosphatidylcholine and produced the water-soluble ..
  24. ncbi Investigating the TNP-OVA and direct popliteal lymph node assays for the detection of immunostimulation by drugs associated with anaphylaxis in humans
    Bradford W Gutting
    Drug Safety Evaluation, Pfizer Global Research and Development, Groton Laboratories, Groton, CT 06340, USA
    J Appl Toxicol 22:177-83. 2002
    ....
  25. ncbi Development of the natural response of immunoglobulin secreting cells in the pig as a function of organ, age and housing
    A T Bianchi
    Department of Mammalian Virology, DLO Institute of Animal Science and Health, Lelystad, The Netherlands
    Dev Comp Immunol 23:511-20. 1999
    ....
  26. ncbi Relative roles of pneumolysin and hydrogen peroxide from Streptococcus pneumoniae in inhibition of ependymal ciliary beat frequency
    R A Hirst
    Department of Child Health, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
    Infect Immun 68:1557-62. 2000
    ..There is also a slight additive effect of pneumolysin and H(2)O(2) on ependymal toxicity; however, the precise mechanism of action and the role of these toxins in pathogenesis remain unclear...
  27. ncbi Roles of CaM kinase II and phospholamban in SNP-induced relaxation of murine gastric fundus smooth muscles
    Minkyung Kim
    Dept of Physiology and Cell Biology, Univ of Nevada School of Medicine, Anderson Bldg MS352, Reno, NV 89557, USA
    Am J Physiol Cell Physiol 291:C337-47. 2006
    ..Our findings that caffeine relaxes and hyperpolarizes murine gastric fundus smooth muscles and increases phospholamban (PLB) phosphorylation by Ca2+/calmodulin (CaM)-dependent protein kinase II (CaM kinase II) suggest that PLB ..
  28. ncbi Viscum album agglutinin-I induces degradation of cytoskeletal proteins in leukaemia PLB-985 cells differentiated toward neutrophils: cleavage of non-muscle myosin heavy chain-IIA by caspases
    Valérie Lavastre
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, QC, Canada
    Br J Haematol 138:545-54. 2007
    The role of the anti-cancer agent Viscum album agglutinin-I (VAA-I) in leukaemia PLB-985 cells differentiated toward a neutrophil-like phenotype by dimethylsulphoxide (PLB-985D) has never been studied...
  29. ncbi Reduced inhibitor 1 and 2 activity is associated with increased protein phosphatase type 1 activity in left ventricular myocardium of one-kidney, one-clip hypertensive rats
    Ramesh C Gupta
    Cardiovascular Medicine, Department of Medicine, Henry Ford Heart and Vascular Institute, Henry Ford Health System, Detroit, MI 48202, USA
    Mol Cell Biochem 269:49-57. 2005
    ..activity and protein expression of PP1, INH-1 and INH-2 and phosphorylation of sarcoplasmic reticulum (SR) phospholamban (PLB), a substrate of PP1 and modulator of SR Ca2+-ATPase activity, in failing and non-failing hearts...
  30. ncbi The homeostasis of phosphatidylcholine and lysophosphatidylcholine was not disrupted during tri-o-cresyl phosphate-induced delayed neurotoxicity in hens
    Wei Yuan Hou
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Datunlu Road, Beijing 100101, PR China
    Toxicology 252:56-63. 2008
    ..of OPIDN have recently been discovered that NTE acts as lysophospholipase (LysoPLA) in mice and phospholipase B (PLB) in cultured mammalian cells...
  31. ncbi Defective Ca(2+) handling proteins regulation during heart failure
    S T Hu
    Department of Biophysics, Second Military Medical University, Shanghai, People s Republic of China
    Physiol Res 60:27-37. 2011
    ..calmodulin, sorcin, calsequestrin, protein phosphatase 1, protein phosphatase 2A), Ca(2+) ATPase (SERCA2a), PLB phosphorylation at Ser16 (PLB-S16), PLB phosphorylation at Thr17 (PLB-T17), L-type Ca(2+) channel (Cav1...
  32. ncbi Popliteal lymph node enlargement and antibody production in the mouse induced by zimeldine and related compounds with varying side chains
    C Thomas
    Research Institute of Toxicology, University of Utrecht, The Netherlands
    Int J Immunopharmacol 12:561-8. 1990
    ..The capacity of the compounds to induce PLN responses appeared not related to their pharmacological potential to inhibit the reuptake of serotonin and noradrenaline.(ABSTRACT TRUNCATED AT 250 WORDS)..
  33. ncbi Role of dual-site phospholamban phosphorylation in the stunned heart: insights from phospholamban site-specific mutants
    M Said
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas 60 y 120, 1900 La Plata, Argentina
    Am J Physiol Heart Circ Physiol 285:H1198-205. 2003
    Phosphorylation of phospholamban (PLB) at Ser16 (protein kinase A site) and at Thr17 [Ca2+/calmodulin kinase II (CaMKII) site] increases sarcoplasmic reticulum Ca2+ uptake and myocardial contractility and relaxation...
  34. ncbi Structural requirements for hydantoins and 2-thiohydantoins to induce lymphoproliferative popliteal lymph node reactions in the mouse
    M E Kammuller
    Department of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Sciences, University of Utrecht, The Netherlands
    Int J Immunopharmacol 10:997-1010. 1988
    ..The PLN assay may therefore be useful as a preliminary short-term screening method for identification of (classes of) compounds able to induce lymphoproliferative reactions.(ABSTRACT TRUNCATED AT 400 WORDS)..
  35. ncbi Comparable levels of Ca-ATPase inhibition by phospholamban in slow-twitch skeletal and cardiac sarcoplasmic reticulum
    Deborah A Ferrington
    Department of Biochemistry, University of Kansas, Lawrence, Kansas 66045, USA
    Biochemistry 41:13289-96. 2002
    Alterations in expression levels of phospholamban (PLB) relative to the sarcoplasmic reticulum (SR) Ca-ATPase have been suggested to underlie defects of calcium regulation in the failing heart and other cardiac pathologies...
  36. ncbi Molecular karyotype variation in Leishmania (Viannia) peruviana: indication of geographical populations in Peru distributed along a north-south cline
    J C Dujardin
    Laboratory of Protozoology, Institute of Tropical Medicine, Prince Leopold, Antwerpen, Belgium
    Ann Trop Med Parasitol 87:335-47. 1993
    ..All the isolates could be distinguished from L. braziliensis by their pLb-134 hybridization patterns...
  37. ncbi Phospholamban oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase binding measured by fluorescence resonance energy transfer in living cells
    Eileen M Kelly
    Department of Physiology, Loyola University Chicago, Maywood, Illinois 60153, USA
    J Biol Chem 283:12202-11. 2008
    b>Phospholamban (PLB) oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase (SERCA) binding were quantified by fluorescence resonance energy transfer (FRET) in an intact cellular environment...
  38. ncbi [Effects of NADPH oxidase inhibition on cardiac function and myocardial calcium regulatory proteins in rabbits with heart failure]
    Yu Liu
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:883-6. 2009
    ..To investigate the effects of NADPH oxidase inhibition on cardiac function and myocardial calcium regulatory proteins mRNA expressions in rabbits with heart failure (HF)...
  39. ncbi Mouse popliteal lymph node assay for assessment of allergic and autoimmunity-inducing potentials of low-molecular-weight drugs
    K Shinkai
    Japan Pharmaceutical Manufacturers Association, Tokyo, Japan
    J Toxicol Sci 24:95-102. 1999
    ....
  40. ncbi Effects of simvastatin on cardiac performance and expression of sarcoplasmic reticular calcium regulatory proteins in rat heart
    Xia Zheng
    The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
    Acta Pharmacol Sin 26:696-704. 2005
    ..function and the alteration of gene and protein expression of the sarcoplasmic calcium regulatory proteins, including sarcoplasmic reticulum Ca2+-ATPase (SERCA), phospholamban (PLB), and ryanodine receptor 2 (RyR2) in rat hearts.
  41. ncbi Role of phospholamban in cyclic GMP mediated signaling in cardiac myocytes
    Qihang Zhang
    Heart and Brain Circulation Laboratory, Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854 8021, USA
    Cell Physiol Biochem 20:157-66. 2007
    ..the hypothesis that the negative functional effects of cyclic GMP on cardiac myocytes were mediated through phospholamban (PLB) and activation of sarcoplasmic reticulum Ca(2+)-ATPase...
  42. ncbi [Anatomic and clinical study on 4-bone-tunnel double-bundle anterior cruciate ligament]
    Jia kuo Yu
    Institute of Sports Medicine, Peking University Third Hospital, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 89:2019-24. 2009
    ..To conduct a primary clinical analysis on 411 cases of arthroscopic 4 bone-tunnel double-bundle anterior cruciate ligament (ACL) reconstruction done by one operator on the basis of anatomic measurements of cadaver knees...
  43. ncbi Applicability of the popliteal lymph node assay in the Brown-Norway rat
    F Verdier
    Laboratoire d'Immunotoxicologie Fondamentale et Clinique, INSERM U80-CNRS URA 1177-UCBL, , Lyon, France
    Immunopharmacol Immunotoxicol 12:669-77. 1990
    ..This first set of experiments indicates that the PLN assay is applicable to Brown-Norway rats and warrants further investigation...
  44. ncbi Effects of imposed pursed-lips breathing on respiratory mechanics and dyspnea at rest and during exercise in COPD
    Jadranka Spahija
    School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada
    Chest 128:640-50. 2005
    To investigate the effect of volitional pursed-lips breathing (PLB) on breathing pattern, respiratory mechanics, operational lung volumes, and dyspnea in patients with COPD.
  45. ncbi Phospholamban modulates the functional coupling between nucleotide domains in Ca-ATPase oligomeric complexes in cardiac sarcoplasmic reticulum
    Linda T L Chen
    Biological Sciences Division, Pacific Northwest National Laboratory, P O Box 999, Richland, Washington 99352, USA
    Biochemistry 48:2411-21. 2009
    Oligomeric interactions between Ca-ATPase polypeptide chains and their modulation by phospholamban (PLB) were measured in native cardiac sarcoplasmic reticulum (SR) microsomes...
  46. ncbi Cytosolic phospholipase A2 is responsible for prostaglandin E2 and leukotriene B4 formation in phagocyte-like PLB-985 cells: studies of differentiated cPLA2-deficient PLB-985 cells
    I Furstenberg Liberty
    Department of Clinical Biochemistry, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Leukoc Biol 76:176-84. 2004
    Our previously established model of cytosolic phospholipase A(2) (cPLA(2))-deficient, differentiated PLB-985 cells (PLB-D cells) was used to determine the physiological role of cPLA(2) in eicosanoid production...
  47. ncbi The homeostasis of phosphatidylcholine and lysophosphatidylcholine in nervous tissues of mice was not disrupted after administration of tri-o-cresyl phosphate
    Wei Yuan Hou
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China
    Toxicol Sci 109:276-85. 2009
    Neuropathy target esterase (NTE) is proven to act as a lysophospholipase (LysoPLA) in mice and phospholipase B (PLB) in cultured mammalian cells...
  48. ncbi Familial protein-losing enteropathy and protein-losing nephropathy in Soft Coated Wheaten Terriers: 222 cases (1983-1997)
    M P Littman
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6010, USA
    J Vet Intern Med 14:68-80. 2000
    ..The prognosis is poor. Compared with previously reported intestinal and renal diseases in dogs, a new, distinctive familial predisposition for both PLE and PLN has been recognized in the SCWT breed...
  49. ncbi Competing irradiation techniques for para-aortic lymph nodes: dose distribution and NTCP for the kidney
    Meinhard Nevinny-Stickel
    Department of Therapeutic Radiology and Oncology, Innsbruck Medical University, Innsbruck, Austria
    Int J Radiat Oncol Biol Phys 63:1206-13. 2005
    ....
  50. ncbi Effects of CMAP and electrostatic cutoffs on the dynamics of an integral membrane protein: the phospholamban study
    Y Houndonougbo
    Department of Chemistry, Biochemistry and Institute of Biomedical Studies, Baylor University, 101 Bagby Ave, Waco, TX 76706, USA
    J Biomol Struct Dyn 26:17-34. 2008
    In our effort to understand the microscopic structure and dynamics of phospholamban (PLB), a small integral membrane protein, we have performed a series of 5-20 ns molecular dynamics simulations to explore the influence of environment (..
  51. ncbi Effects on recovery during acidosis in cardiac myocytes overexpressing CaMKII
    Can M Sag
    Department of Cardiology and Pneumology Heart Center, Georg August University Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    J Mol Cell Cardiol 43:696-709. 2007
    ..shortening during late phase acidosis are suggested to be associated with CaMKII-dependent processes of which phospholamban (PLB) phosphorylation may play an important role...
  52. ncbi Lusitropic effects of dobutamine in young and aged mice in vivo
    Emily D Hirleman
    Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, Arizona 85724, USA
    J Extra Corpor Technol 40:10-5. 2008
    ..elements by sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA2a), which is regulated by an inhibitory protein, phospholamban (PLB)...
  53. ncbi Role of leucine 31 of phospholamban in structural and functional interactions with the Ca2+ pump of cardiac sarcoplasmic reticulum
    Zhenhui Chen
    Krannert Institute of Cardiology and the Department of Medicine, Indiana University School of Medicine, 1800 N Capitol Ave, Indianapolis, Indiana 46202, USA
    J Biol Chem 280:10530-9. 2005
    The ability of two loss-of-function mutants, L31A and L31C, of phospholamban (PLB) to bind to and inhibit the Ca(2+) pump of cardiac sarcoplasmic reticulum (SERCA2a) was investigated using a molecular cross-linking approach...
  54. ncbi Increased particulate partitioning of PKC epsilon reverses susceptibility of phospholamban knockout hearts to ischemic injury
    Kimberly N Gregory
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0575, USA
    J Mol Cell Cardiol 36:313-8. 2004
    ..of sarcoplasmic reticulum Ca(2+) cycling through inhibition or ablation of the Ca(2+) ATP-ase inhibitor phospholamban (PLN), which shows promise as a treatment for heart failure, could be beneficial in ischemic heart disease...
  55. ncbi Peptide inhibitors use two related mechanisms to alter the apparent calcium affinity of the sarcoplasmic reticulum calcium pump
    Michael R Afara
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Biochemistry 47:9522-30. 2008
    The primary sequence of phospholamban (PLB) has provided a template for the rational design of peptide inhibitors of the sarcoplasmic reticulum calcium ATPase (SERCA)...
  56. ncbi Femoral bone strength and its relation to cortical and trabecular changes after treatment with PTH, alendronate, and their combination as assessed by finite element analysis of quantitative CT scans
    Tony M Keaveny
    Department of Mechanical Engineering, University of California, Berkeley, California 94720 1740, USA
    J Bone Miner Res 23:1974-82. 2008
    ..were assigned to either PTH, ALN, or their combination (CMB) in year 1 and were switched to either ALN or placebo (PLB) treatment in year 2: PTH-PLB, PTH-ALN, CMB-ALN, and ALN-ALN (year 1-year 2) treatments...
  57. ncbi Depressed contractile reserve and impaired calcium handling of cardiac myocytes from chronically unloaded hearts are ameliorated with the administration of physiological treatment dose of T3 in rats
    Y Minatoya
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Acta Physiol (Oxf) 189:221-31. 2007
    Chronic cardiac unloading causes a time-dependent upregulation of phospholamban (PLB) and depression of myocyte contractility in normal rat hearts...
  58. ncbi Chemoattractant mechanism of Th1 cells in class III and IV lupus nephritis
    Shinji Morimoto
    Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
    Autoimmunity 42:143-9. 2009
    ..These findings suggest that combination of Th1 inducers and chemokine inhibition might be powerful threrapeutic approach in PLN...
  59. ncbi Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice
    Tong Zhang
    Department of Pharmacology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0636, USA
    Circ Res 106:354-62. 2010
    ..We hypothesized that phospholamban (PLN) ablation would restore SR Ca(2+) load and prevent the decreased ventricular contractility, dilation and ..
  60. ncbi Potential risks of femoral tunnel drilling through the far anteromedial portal: a cadaveric study
    Mitsuhiro Nakamura
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Arthroscopy 25:481-7. 2009
    ..The purpose of this study was to estimate the potential risks when drilling femoral tunnels through the far anteromedial portal in double-bundle anterior cruciate ligament reconstruction in cadaveric knees...
  61. ncbi Perlecan knockdown in metastatic prostate cancer cells reduces heparin-binding growth factor responses in vitro and tumor growth in vivo
    Cristiana Savorè
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Clin Exp Metastasis 22:377-90. 2005
    ..We conclude that Pln is an essential ECM component involved in growth responses of metastatic prostate cancer cells to HBGFs deposited in local and metastatic microenvironment...
  62. ncbi [Comparison of cardiac function and expression and activity of myocardial calcium regulatory proteins in rabbit systolic and diastolic heart failure models.]
    Lei Wang
    Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China E mail
    Sheng Li Xue Bao 61:551-8. 2009
    ..The mRNA expression levels of sarcoplasmic reticulum Ca(2+) ATPase 2a (SERCA2a) and phospholamban (PLB) were evaluated by RT-PCR...
  63. ncbi Elevated levels of endogenous adenosine alter metabolism and enhance reduction in contractile function during low-flow ischemia: associated changes in expression of Ca(2+)-ATPase and phospholamban
    H T Sommerschild
    Institute for Experimental Medical Research, Ulleval Hospital, Oslo, Norway
    J Mol Cell Cardiol 31:1897-911. 1999
    ..catecholamine-induced increase in contractile function mainly through inhibition of phosphorylation of phospholamban (PLB), the main regulatory protein of Ca(2+)-ATPase in sarcoplasmic reticulum (SR), and during ischemia it ..
  64. ncbi Popliteal lymph node reactions in mice induced by the drug zimeldine
    C Thomas
    Department of Toxicology, University of Utrecht, The Netherlands
    Int J Immunopharmacol 11:693-702. 1989
    ..The protracted nature of the reaction may indicate that zimeldine somehow interferes with inhibitory feedback mechanisms...
  65. ncbi Expression of slow skeletal troponin I in hearts of phospholamban knockout mice alters the relaxant effect of beta-adrenergic stimulation
    Beata M Wolska
    Department of Medicine, Section of Cardiology, University of Illinois at Chicago, Chicago, Ill 60612 7323, USA
    Circ Res 90:882-8. 2002
    ..in an enhanced relaxation rate in association with phosphorylation of both cardiac troponin I (cTnI) and phospholamban (PLB)...
  66. ncbi Vasodilator-stimulated phosphoprotein regulates inside-out signaling of beta2 integrins in neutrophils
    Ravi K Deevi
    Centre for Infection and Immunity, Queen s University Belfast, Belfast, Northern Ireland, United Kingdom
    J Immunol 184:6575-84. 2010
    ..found that fMLP-induced activation of Rap1 in human polymorphonuclear leukocytes or neutrophils and differentiated PLB-985 cells was blocked by inhibitors of the NO/guanosine-3',5'-cyclic monophosphate-dependent protein kinase (cGKI) ..
  67. ncbi Identification of functional domains of rat intestinal phospholipase B/lipase. Its cDNA cloning, expression, and tissue distribution
    H Takemori
    Department of Molecular Physiological Chemistry, Osaka University Medical School, Japan
    J Biol Chem 273:2222-31. 1998
    A cDNA encoding a rat intestinal Ca(2+)-independent phospholipase B/lipase (PLB/LIP) was cloned from an ileac mucosa cDNA library using a probe amplified by polymerase chain reaction based on the purified enzyme's sequence...
  68. ncbi Lymphocyte populations and adhesion molecule expression in bovine tonsils
    M C Rebelatto
    Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907 1243, USA
    Vet Immunol Immunopathol 73:15-29. 2000
    ..Similarities between the human and bovine tonsils suggest that cattle may provide a good model to study the role of the tonsil in the respiratory immune response...
  69. ncbi Mechanism of reversal of phospholamban inhibition of the cardiac Ca2+-ATPase by protein kinase A and by anti-phospholamban monoclonal antibody 2D12
    Zhenhui Chen
    Krannert Institute of Cardiology and the Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 282:20968-76. 2007
    Our model of phospholamban (PLB) regulation of the cardiac Ca(2+)-ATPase in sarcoplasmic reticulum (SERCA2a) states that PLB binds to the Ca(2+)-free, E2 conformation of SERCA2a and blocks it from transitioning from E2 to E1, the Ca(2+)-..
  70. ncbi Fine ambient particles from various sites in europe exerted a greater IgE adjuvant effect than coarse ambient particles in a mouse model
    Torunn Alberg
    Norwegian Institute of Public Health, Division of Environmental Medicine, Oslo, Norway
    J Toxicol Environ Health A 72:1-13. 2009
    ....
  71. ncbi Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity
    Béatrice Regnault
    Immunophysiology and Intracellular Parasitism Unit, Department of Parasitology and Mycology, 75015 Paris, France
    BMC Med Genomics 2:63. 2009
    ..Analysis of gene expression profiles has the potential to provide a global understanding of the disease and to generate novel hypothesis concerning the initiation of the autoimmune process...
  72. ncbi Probing excited states and activation energy for the integral membrane protein phospholamban by NMR CPMG relaxation dispersion experiments
    Nathaniel J Traaseth
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55445, USA
    Biochim Biophys Acta 1798:77-81. 2010
    b>Phospholamban (PLN) is a dynamic single-pass membrane protein that inhibits the flow of Ca(2+) ions into the sarcoplasmic reticulum (SR) of heart muscle by directly binding to and inhibiting the SR Ca(2+)ATPase (SERCA)...
  73. ncbi Radiologic evaluation of the insertion sites of the 2 functional bundles of the anterior cruciate ligament using 3-dimensional computed tomography
    Stephan Lorenz
    Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Am J Sports Med 37:2368-76. 2009
    ..Reference values for the anatomic insertions are necessary for radiographic intra- and postoperative control and fluoroscopy-based navigation...
  74. ncbi Description of the attachment geometry of the anteromedial and posterolateral bundles of the ACL from arthroscopic perspective for anatomical tunnel placement
    Joan W H Luites
    Research, Development and Education, OrthoResearch Unit, Sint Maartenskliniek, P O Box 9011, 6500 GM, Nijmegen, The Netherlands
    Knee Surg Sports Traumatol Arthrosc 15:1422-31. 2007
    The anterior cruciate ligament (ACL) consists of an anteromedial bundle (AMB) and a posterolateral bundle (PLB)...
  75. ncbi Solution structure of the cytoplasmic domain of phopholamban: phosphorylation leads to a local perturbation in secondary structure
    R J Mortishire-Smith
    Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, United Kingdom
    Biochemistry 34:7603-13. 1995
    Peptides representing the N-terminal domain (Ia) of the cardiac sarcoplasmic reticulum protein phospholamban (residues 1-25 [PLB(1-25)] and a phosphorylated form [pPLB(1-25)]) were synthesized and their conformations examined using ..
  76. ncbi Chronic human immunodeficiency virus type 1 infection stimulates distinct NF-kappa B/rel DNA binding activities in myelomonoblastic cells
    A Roulston
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 67:5235-46. 1993
    ..induction of NF-kappa B binding activity was examined in a myeloid cell model of HIV-1 infection derived from the PLB-985 cell line...
  77. ncbi Influence of prolactin and growth hormone on the activation of dwarf mouse lymphocytes in vivo
    R R Gala
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201
    Proc Soc Exp Biol Med 204:224-30. 1993
    ..These findings strongly suggest that PRL and/or GH play an important role at some stage of the T cell activation process in vivo. Further studies are needed to precisely identify the defect in the dwarf mice...
  78. ncbi Identification of the druggable concavity in homology models using the PLB index
    Shinji Soga
    Molecular Medicine Research Laboratories, Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    J Chem Inf Model 47:2287-92. 2007
    ..We previously proposed an index named PLB (propensity for ligand binding), which is based on the amino acid composition characteristically observed at the ..
  79. ncbi Low-dose intramuscular polymyxin B improves survival of septic rats
    T Mayumi
    Department of Emergency Medicine, Nagoya University School of Medicine, Japan
    Shock 11:82-6. 1999
    Polymyxin B (PLB) is a cationic antibiotic that also stoichiometrically neutralizes the lipid A moiety of endotoxin...
  80. ncbi Förster transfer recovery reveals that phospholamban exchanges slowly from pentamers but rapidly from the SERCA regulatory complex
    Seth L Robia
    Department of Physiology, 102 5609, Loyola University Chicago, 2160 South First Ave, Maywood, IL 60153, USA
    Circ Res 101:1123-9. 2007
    b>Phospholamban (PLB) or the sarcoplasmic reticulum Ca2+-ATPase (SERCA) were fused to cyan fluorescent protein (CFP) and coexpressed with PLB fused to yellow fluorescent protein (YFP)...
  81. ncbi Differential effects of phospholamban and Ca2+/calmodulin-dependent kinase II on [Ca2+]i transients in cardiac myocytes at physiological stimulation frequencies
    Andreas A Werdich
    Department of Biomedical Engineering, Vanderbilt University, 6301 Stevenson Center, VU Station B 351631, Nashville, TN 37235 1631, USA
    Am J Physiol Heart Circ Physiol 294:H2352-62. 2008
    ..from and Ca(2+) uptake into the sarcoplasmic reticulum via the phosphorylation of the ryanodine receptor 2 and phospholamban (PLN), respectively...
  82. ncbi Regulation of sarcoplasmic reticulum Ca2+ reuptake in porcine airway smooth muscle
    Venkatachalem Sathish
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Lung Cell Mol Physiol 294:L787-96. 2008
    ..We examined regulation of SERCA in porcine ASM: our hypothesis was that the regulatory protein phospholamban (PLN) and the calmodulin (CaM)-CaM kinase (CaMKII) pathway (both of which are known to regulate SERCA in ..
  83. ncbi Targeted ablation of the phospholamban gene is associated with a marked decrease in sensitivity in aortic smooth muscle
    J Lalli
    University of Cincinnati, College of Medicine, Department of Molecular and Cellular Physiology, OH 45267 0576, USA
    Circ Res 80:506-13. 1997
    b>Phospholamban (PLB) is a protein associated with the Ca(2+)-ATPase of the sarcoplasmic reticulum (SR) in cardiac, slow-twitch skeletal, and smooth muscle...
  84. ncbi Solid-state (2)H and (15)N NMR studies of side-chain and backbone dynamics of phospholamban in lipid bilayers: investigation of the N27A mutation
    Shidong Chu
    Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
    Biochim Biophys Acta 1798:210-5. 2010
    b>Phospholamban (PLB) is an integral membrane protein regulating Ca(2+) transport through inhibitory interaction with sarco(endo)plasmic reticulum calcium ATPase (SERCA)...
  85. ncbi [Construction of lentiviral vector carrying human VE-cadherin gene and expression of VE-cadherin in leukemic cell line Sup-B15]
    Huan Xin Zhang
    Laboratory of Transplantation Immunology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:574-7. 2011
    ..The VE-cadherin DNA fragment was subcloned into pLB vector to generate a lentiviral vector pLB-VEC...
  86. ncbi The relationship between different spectral forms of the protochlorophyllide oxidoreductase complex and the structural organisation of prolamellar bodies isolated from Zea mays
    Eva Selstam
    Umea Plant Science Centre, Department of Plant Physiology, University of Umea, Umea, Sweden
    Photosynth Res 108:47-59. 2011
    Incubation of prolamellar bodies (PLB) in high-salt media leads to changes in PLB structure and properties of their protochlorophyllide oxidoreductase-protochlorophyllide (POR-PChlide) complex...
  87. ncbi Efficacy of aripiprazole adjunctive to lithium or valproate in the long-term treatment of patients with bipolar I disorder with an inadequate response to lithium or valproate monotherapy: a multicenter, double-blind, randomized study
    Ronald Marcus
    Bristol Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA
    Bipolar Disord 13:133-44. 2011
    ..safety of aripiprazole (ARI) adjunctive to lithium (Li) or valproate (Val) (ARI+Li?/?Val) compared with placebo (PLB) adjunctive to Li or Val (PLB+Li?/?Val) as maintenance therapy for patients with bipolar I disorder who had an ..
  88. ncbi New dendronized polymers from acrylate Behera amine and their ability to produce visco-elastic structured fluids when mixed with CTAT worm-like micelles
    Julio C Cuggino
    Departamento de Quimica Organica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    J Colloid Interface Sci 357:147-56. 2011
    ..However, such synergistic viscosity enhancement saturated at rather low concentrations (25ppm) indicating an apparent lower solubility as compared to PL1, a fact that may be related to its higher molecular weight...
  89. ncbi SERCA2a superinhibition by human phospholamban triggers electrical and structural remodeling in mouse hearts
    Hong Sheng Wang
    Department of Pharmacology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0575, USA
    Physiol Genomics 43:357-64. 2011
    b>Phospholamban (PLN), the reversible inhibitor of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a), is a key regulator of myocyte Ca(2+) cycling with a significant role in heart failure...
  90. ncbi Does pelvic lymph nodes irradiation using intensity modulated radiation therapy increase rectal and bladder toxicities in patients with prostate carcinoma?
    M Garipagaoglu
    Acibadem University, Department of Radiation Oncology, Istanbul, Turkey
    J BUON 15:668-73. 2010
    ....
  91. ncbi PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: summary of the literature and implications for genetic testing
    Andrew P Landstrom
    Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA
    Am Heart J 161:165-71. 2011
    ..We sought to determine the spectrum and prevalence of mutations in PLN-encoded phospholamban in a large cohort of HCM cases as a potential cause of mutation-negative HCM.
  92. ncbi Clinical characterization and prognostic factors of primary lymphoma of bone in case of Chinese patients
    Jia Jia Huang
    State Key Laboratory of Oncology in Southern China, Department of Medical Oncology, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, China
    Med Oncol 28:S476-82. 2011
    Primary lymphoma of bone (PLB) is a very rare neoplasm. Many aspects of this entity have not been well defined or reported in Chinese population. The purpose of our study is to identify the prognostic factors of PLB...
  93. ncbi Factors discriminating spontaneous pursed-lips breathing use in patients with COPD
    Jadranka Spahija
    McGill University, Montreal, Quebec, Canada
    COPD 7:254-61. 2010
    Pursed-lips breathing (PLB) is often spontaneously performed by chronic obstructive pulmonary disease (COPD) patients. The aim of this study was to evaluate spontaneous PLB prevalence and to identify factors discriminating its use...
  94. ncbi Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy
    Shunichi Yokoe
    Department of Biochemistry, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Glycobiology 20:1217-26. 2010
    ..b>Phospholamban (PLN) regulates the function of SERCA2a via its Ser(16)-phosphorylation...
  95. ncbi A novel custom resequencing array for dilated cardiomyopathy
    Rebekah S Zimmerman
    Laboratory for Molecular Medicine, Partners Healthcare Center for Personalized Genetic Medicine, Cambridge, Massachusetts 02139, USA
    Genet Med 12:268-78. 2010
    ..Novel sequencing platforms have now opened up avenues for more comprehensive diagnostic testing while simultaneously decreasing test cost and turn around time...
  96. ncbi Afa/Dr-expressing, diffusely adhering Escherichia coli strain C1845 triggers F1845 fimbria-dependent phosphatidylserine externalization on neutrophil-like differentiated PLB-985 cells through an apoptosis-independent mechanism
    Nicolas Sémiramoth
    INSERM, UMR756 Signalisation et Physiopathologie des Cellules Epithéliales, and Universite Paris Sud XI, Faculte de Pharmacie, Chatenay Malabry, France
    Infect Immun 78:2974-83. 2010
    ..Using the human PLB-985 cell line differentiated into fully mature neutrophils, we found that the wild-type enterovirulent E...
  97. ncbi Real-time PCR expression profiling of genes encoding potential virulence factors in Candida albicans biofilms: identification of model-dependent and -independent gene expression
    Heleen Nailis
    Laboratory for Pharmaceutical Microbiology, Universiteit Gent, Harelbekestraat 72, B 9000, Ghent, Belgium
    BMC Microbiol 10:114. 2010
    ..wall protein) and of genes belonging to the ALS (agglutinin-like sequence), SAP (secreted aspartyl protease), PLB (phospholipase B) and LIP (lipase) gene families is associated with biofilm growth on mucosal surfaces...
  98. ncbi Repression of cardiac phospholamban gene expression is mediated by thyroid hormone receptor-{alpha}1 and involves targeted covalent histone modifications
    Madesh Belakavadi
    Department of Physiology and Biophysics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Endocrinology 151:2946-56. 2010
    b>Phospholamban (PLB) is a critical regulator of Ca(2+) cycling in heart muscle cells, and its gene expression is markedly down-regulated by T(3)...
  99. ncbi (15)N Solid-state NMR spectroscopic studies on phospholamban at its phosphorylated form at ser-16 in aligned phospholipid bilayers
    Shidong Chu
    Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, USA
    Biochim Biophys Acta 1798:312-7. 2010
    Wild-type phospholamban (WT-PLB) is a pentameric transmembrane protein that regulates the cardiac cycle (contraction and relaxation)...
  100. ncbi Ca2+ binding to site I of the cardiac Ca2+ pump is sufficient to dissociate phospholamban
    Zhenhui Chen
    Department of Medicine, Indiana University School of Medicine, Krannert Institute of Cardiology, Indianapolis, Indiana 46202, USA
    J Biol Chem 285:3253-60. 2010
    b>Phospholamban (PLB) inhibits the activity of SERCA2a, the Ca(2+)-ATPase in cardiac sarcoplasmic reticulum, by decreasing the apparent affinity of the enzyme for Ca(2+)...
  101. ncbi Activating and deactivating roles of lipid bilayers on the Ca(2+)-ATPase/phospholamban complex
    Martin Gustavsson
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, United States
    Biochemistry 50:10367-74. 2011
    ..the sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA) in the presence and absence of its endogenous regulator, phospholamban (PLN)...

Research Grants83

  1. Characterizing autoimmunity in NOD mouse islets, PLN and spleen
    Daniel Kaufman; Fiscal Year: 2007
    ..The results will help guide our thinking on potential therapeutic approaches, as well as the utility of biomarkers based on peripheral T cell responses. ..
  2. Cardiac Sarcoplasmic Reticulum Calcium Cycling Proteins
    Evangelia G Kranias; Fiscal Year: 2010
    ..SR Ca-uptake during diastole is mediated by SERCA2a and its reversible regulator phospholamban (PLN);Ca is stored by calsequestrin;and Ca is released during systole through the ryanodine receptor and its ..
  3. Calcium Handling in Cardiac Pathophysiology
    Evangelia Kranias; Fiscal Year: 2009
    ..The major functions of the SR are: Ca-uptake mediated by SERCA2a and its reversible regulator phospholamban (PLN); Ca-storage through calsequestrin and the histidine rich Ca-binding protein (HRC); and Ca-release ..
  4. Calcium Handling in Cardiac Pathophysiology
    Evangelia G Kranias; Fiscal Year: 2010
    ..The major functions of the SR are: Ca-uptake mediated by SERCA2a and its reversible regulator phospholamban (PLN);Ca-storage through calsequestrin and the histidine rich Ca-binding protein (HRC);and Ca-release ..
  5. Mechanisms regulating SR Ca2+ ATPase in the Atria
    Muthu Periasamy; Fiscal Year: 2010
    ..The activity of SERCA pump is regulated by two small molecular weight proteins, phospholamban (PLB) and sarcolipin (SLN)...
  6. AKAP Regulation of PKA Targeting in the Heart
    Meredith Bond; Fiscal Year: 2009
    ..We also demonstrated that phosphorylation of Rll, and PKA substrates (Tnl, MBP-C and PLB), is decreased in failing human hearts...
  7. Phospholemman and Na-Pump Function in Cardiac Myocytes
    Donald M Bers; Fiscal Year: 2010
    ..During the initial award period, we showed that PLM regulates NKA similar to the way phospholamban (PLB) regulates SR Ca-ATPase (SERCA)...
  8. Troponin and Heart Function in Health and Disease
    JOSEPH MARK METZGER; Fiscal Year: 2010
    ..Therefore the health relevance of the proposal is substantial and highly significant to the mission of the National Institutes of Health. ..
  9. NMR Structural Analysis of Calcium Regulation in Muscle
    Gianluigi Veglia; Fiscal Year: 2010
    ..SERCA's function is regulated by two membrane inhibitors: phospholamban (PLN) and sarcolipin (PLN), expressed primarily in cardiac and skeletal muscle, respectively...
  10. RECEPTOR TOPOGRAPHY IN MICROVASCULAR LEUKOCYTE ADHESION
    Ulrich von Andrian; Fiscal Year: 2005
    ..This may lead to a better understanding of physiologic and pathologic phenomena in PLN and result in improved vaccination protocols against tumors, infections and inflammatory diseases. ..
  11. Cardiac Sarcoplasmic Reticulum Calcium Cycling Proteins
    Evangelia Kranias; Fiscal Year: 2009
    ..The main SR proteins responsible for these functions are: the Ca-transport ATPase (SERCA2) with its regulator phospholamban (PLN); the Ca-storage proteins, calsequestrin and a histidine rich Ca-binding protein (HRC); and the Ca-..
  12. Cardiac Sarcoplasmic Reticulum Calcium Cycling Proteins
    Evangelia Kranias; Fiscal Year: 2007
    ..The main SR proteins responsible for these functions are: the Ca-transport ATPase (SERCA2) with its regulator phospholamban (PLN); the Ca-storage proteins, calsequestrin and a histidine rich Ca-binding protein (HRC); and the Ca-..
  13. CaMKII in Sinus Node Physiology and Disease
    Mark Anderson; Fiscal Year: 2009
    ..kinase II (CaMKII) is a serine- threonine kinase that regulates the SR-associated Ca2+ homeostatic proteins, phospholamban (PLN) and ryanodine receptors (RyR)...
  14. CaMKII in Sinus Node Physiology and Disease
    Mark E Anderson; Fiscal Year: 2010
    ..kinase II (CaMKII) is a serine- threonine kinase that regulates the SR-associated Ca2+ homeostatic proteins, phospholamban (PLN) and ryanodine receptors (RyR)...
  15. DIABETIC CARDIOMYOPATHY AND CALCIUM FLUX
    Wolfgang Dillmann; Fiscal Year: 2003
    ..sarcoplasmic reticulum (SR) calcium loading, calcium spark patterns and NA+/Ca exchanger activity and the phospholamban (Plb) phosphorylation status...
  16. Deaf1 isoforms control changes in PTA expression in the NOD PLN during T1D pathog
    CHARLES GARRISON FATHMAN; Fiscal Year: 2010
    ..The studies proposed here will examine the role of Deaf1 in maintaining peripheral tolerance and help us understand how a change in Deaf1 splicing may contribute to the pathogenesis of T1D. ..
  17. Structural Dynamics of Muscle Calcium ATPase Regulation
    DAVID DALE THOMAS; Fiscal Year: 2010
    ..SERCA), the large integral membrane enzyme that pumps calcium into the SR and thus relaxes the muscle, and on phospholamban (PLB), the small integral membrane protein that regulates SERCA in the heart...
  18. T Cell Reactivity in Human Pancreatic Draining Lymph Nodes in Type 1 Diabetes
    David Hafler; Fiscal Year: 2003
    ..These investigations are designed to provide novel targets and approaches for the treatment of human autoimmune disease. ..
  19. BIOPHYSICAL STUDIES OF MEMBRANE MOLECULAR DYNAMICS
    David Thomas; Fiscal Year: 2007
    ..SERCA), the large integral membrane enzyme that pumps calcium into the SR and thus relaxes the muscle, and phospholamban (PLB) and sarcolipin (SLN), the small integral membrane proteins that regulate SERCA...
  20. BIOPHYSICAL STUDIES OF MEMBRANE MOLECULAR DYNAMICS
    David Thomas; Fiscal Year: 2003
    ..on the Ca-ATPase, the integral membrane enzyme that pumps calcium into the SR and thus relaxes the muscle, and phospholamban (PLB), the integral membrane peptide involved in regulating the Ca-ATPase in the heart...
  21. T Cell Activation in Lymph nodes
    Ulrich H von Andrian; Fiscal Year: 2010
    ..This information may lead to improved strategies for clinical immunomodulation, e.g. for vaccinations, tumor therapy and treatment of infectious, inflammatory and autoimmune diseases. ..
  22. T Cell Activation in Lymph nodes
    Ulrich von Andrian; Fiscal Year: 2009
    ..This information may lead to improved strategies for clinical immunomodulation, e.g. for vaccinations, tumor therapy and treatment of infectious, inflammatory and autoimmune diseases. ..
  23. T Cell Activation in Lymph nodes
    Ulrich von Andrian; Fiscal Year: 2007
    ..This information may lead to improved strategies for clinical immunomodulation, e.g. for vaccinations, tumor therapy and treatment of infectious, inflammatory and autoimmune diseases. ..
  24. ClC-3 ion transport modulates NADPH oxidase-dependent PMN priming by endotoxin
    Jessica G Moreland; Fiscal Year: 2010
    ..Whole cell patch clamp analysis of human and murine PMNs along with differentiated PLB cells will be employed to directly observe the relevant conductances, and will allow the use of molecular tools to ..
  25. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    ROGER JOSEPH HAJJAR; Fiscal Year: 2010
    ..with a decrease in the activity of the SR Ca2+-ATPase (SERCA2a), which is at least partially due to enhanced phospholamban (PLN) inhibition...
  26. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    ROGER JOSEPH HAJJAR; Fiscal Year: 2011
    ..with a decrease in the activity of the SR Ca2+-ATPase (SERCA2a), which is at least partially due to enhanced phospholamban (PLN) inhibition...
  27. PHOSPHOLIPASE B--MECHANISMS AUGMENTING CANDIDA VIRULENCE
    Mahmoud Ghannoum; Fiscal Year: 2003
    ..on exploiting the concept of candidal virulence by identifying and characterizing factors, such as phospholipase B (PLB), that augment the pathogenicity of this important nosocomial pathogen...
  28. B cells and draining lymph node function in arthritic flair
    Edward Schwarz; Fiscal Year: 2009
    ..Here we propose to test this theory in mouse models and RA patients. ..
  29. Dissection of cellular interactions in T1DM with integrated functional genomics
    Martin Hessner; Fiscal Year: 2009
    ....
  30. Dissection of cellular interactions in T1DM with integrated functional genomics
    MARTIN JOHN HESSNER; Fiscal Year: 2010
    ....
  31. Dissecting Dendritic Cell Function in Autoimmune Diabetes
    Jonathan Katz; Fiscal Year: 2009
    ..Aim 2: To determine if NKT cell-produced INF-9 and pDC-produced IDO establish a regulatory circuit that controls diabetogenic T cells in vivo. ..
  32. Type 1 diabetes: the role of commensal microbiota
    Alexander V Chervonsky; Fiscal Year: 2010
    ....
  33. Dissecting Dendritic Cell Function in Autoimmune Diabetes
    JONATHAN DAVID KATZ; Fiscal Year: 2010
    ..Aim 2: To determine if NKT cell-produced INF-9 and pDC-produced IDO establish a regulatory circuit that controls diabetogenic T cells in vivo. ..
  34. CARDIAC SARCOPLASMIC RETICULIM CALCIUM CYCLING PROTEINS
    Evangelia Kranias; Fiscal Year: 2004
    ..b>Phospholamban is another SR protein, which plays a crucial role in the regulation of the Ca2+-ATPase activity and myocardial ..
  35. The role of syndecan-4 in the regulation of JNK activation in human neutrophils
    PATRICK ARNDT; Fiscal Year: 2007
    ..chemical inhibitors, blocking antibodies, small interfering RNAs, and protein transduction of neutrophils and the PLB-985 cell line, which can be differentiated into neutrophil-like cells...