perlecan

Summary

Gene Symbol: perlecan
Description: heparan sulfate proteoglycan 2
Alias: HSPG, PLC, PRCAN, SJA, SJS, SJS1, basement membrane-specific heparan sulfate proteoglycan core protein, endorepellin (domain V region), perlecan proteoglycan
Species: human

Top Publications

  1. ncbi Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan
    M Kvansakul
    Biophysics Section, Blackett Laboratory, Imperial College, Prince Consort Road, London SW7 2BW, UK
    EMBO J 20:5342-6. 2001
  2. ncbi BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan
    Eva M Gonzalez
    Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:7080-7. 2005
  3. ncbi Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity
    Alexander Nyström
    Department of Pathology, Anatomy, and Cell Biology, and Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Blood 114:4897-906. 2009
  4. ncbi Microfibrils at basement membrane zones interact with perlecan via fibrillin-1
    Kerstin Tiedemann
    Department of Medical Molecular Biology, University of Lubeck, 23538 Lubeck, Germany
    J Biol Chem 280:11404-12. 2005
  5. ncbi Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis
    Maurizio Mongiat
    Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:17491-9. 2003
  6. ncbi Heparanase degrades syndecan-1 and perlecan heparan sulfate: functional implications for tumor cell invasion
    Jane Reiland
    Department of Comparative Biomedical Sciences SVM, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    J Biol Chem 279:8047-55. 2004
  7. ncbi Perlecan is essential for cartilage and cephalic development
    E Arikawa-Hirasawa
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 23:354-8. 1999
  8. ncbi The perlecan heparan sulfate proteoglycan mediates cellular uptake of HIV-1 Tat through a pathway responsible for biological activity
    Elias G Argyris
    The Dorrance H Hamilton Laboratories, Division of Infectious Diseases and Environmental Medicine, Center for Human Virology and Biodefense, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 330:481-6. 2004
  9. ncbi Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan
    Maurizio Mongiat
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:4238-49. 2003
  10. ncbi Signal transduction in esophageal and LES circular muscle contraction
    K M Harnett
    Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
    Yale J Biol Med 72:153-68. 1999

Research Grants

  1. ACTIVATION OF PI-SPECIFIC PHOSPHOLIPASE C ENZYMES
    Mary Roberts; Fiscal Year: 2003
  2. ACTIVATION OF PI-SPECIFIC PHOSPHOLIPASE C ENZYMES
    Mary Roberts; Fiscal Year: 2007
  3. Activation of PI Specific Phospholipase C Enzymes
    MARY FEDARKO ROBERTS; Fiscal Year: 2010
  4. Mechanism for Regulation of Phospholipase C by G Protein
    Alan Smrcka; Fiscal Year: 2005
  5. GPI PHOSPHOLIPASE C OF T BRUCEI
    Kojo Mensa Wilmot; Fiscal Year: 2001
  6. LIPID-PROTEIN INTERACTIONS
    O Griffith; Fiscal Year: 1992
  7. PHOSPHOLIPASE C AND ISLET BETA CELLS
    GRANT KELLEY; Fiscal Year: 2002
  8. REGULATION OF PHOSPHOLIPASE C
    John Sondek; Fiscal Year: 2007
  9. REGULATION OF PHOSPHOLIPASE C
    John Sondek; Fiscal Year: 2007
  10. SIGNAL TRANSDUCTION DEFECTS IN HUMAN PLATELETS
    A Rao; Fiscal Year: 2006

Detail Information

Publications182 found, 100 shown here

  1. ncbi Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan
    M Kvansakul
    Biophysics Section, Blackett Laboratory, Imperial College, Prince Consort Road, London SW7 2BW, UK
    EMBO J 20:5342-6. 2001
    Nidogen and perlecan are large multifunctional basement membrane (BM) proteins conserved in all metazoa...
  2. ncbi BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan
    Eva M Gonzalez
    Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:7080-7. 2005
    Endorepellin, the C-terminal domain of the heparan sulfate proteoglycan perlecan, possesses angiostatic activity...
  3. ncbi Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity
    Alexander Nyström
    Department of Pathology, Anatomy, and Cell Biology, and Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Blood 114:4897-906. 2009
    Endorepellin, the C-terminal domain of perlecan, is a powerful angiogenesis inhibitor. To dissect the mechanism of endorepellin-mediated endothelial silencing, we used an antibody array against multiple tyrosine kinase receptors...
  4. ncbi Microfibrils at basement membrane zones interact with perlecan via fibrillin-1
    Kerstin Tiedemann
    Department of Medical Molecular Biology, University of Lubeck, 23538 Lubeck, Germany
    J Biol Chem 280:11404-12. 2005
    ..Here we demonstrate that the proteoglycan perlecan is an associated component of microfibrils typically close to basement membrane zones...
  5. ncbi Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis
    Maurizio Mongiat
    Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:17491-9. 2003
    The goal of this study was to discover novel partners for perlecan, a major heparan sulfate proteoglycan of basement membranes, and to examine new interactions through which perlecan may influence cell behavior...
  6. ncbi Heparanase degrades syndecan-1 and perlecan heparan sulfate: functional implications for tumor cell invasion
    Jane Reiland
    Department of Comparative Biomedical Sciences SVM, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    J Biol Chem 279:8047-55. 2004
    ..Conversely, another HSPG, perlecan, is an important component of basement membranes and ECM, which can promote invasive behavior...
  7. ncbi Perlecan is essential for cartilage and cephalic development
    E Arikawa-Hirasawa
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 23:354-8. 1999
    b>Perlecan, a large, multi-domain, heparan sulfate proteoglycan originally identified in basement membrane, interacts with extracellular matrix proteins, growth factors and receptors, and influences cellular signalling...
  8. ncbi The perlecan heparan sulfate proteoglycan mediates cellular uptake of HIV-1 Tat through a pathway responsible for biological activity
    Elias G Argyris
    The Dorrance H Hamilton Laboratories, Division of Infectious Diseases and Environmental Medicine, Center for Human Virology and Biodefense, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 330:481-6. 2004
    ..Herein, we report that human WiDr cells, which express perlecan but no other HSPGs, can internalize 125I-labeled Tat with minimal lysosomal degradation...
  9. ncbi Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan
    Maurizio Mongiat
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:4238-49. 2003
    b>Perlecan, a ubiquitous basement membrane heparan sulfate proteoglycan, plays key roles in blood vessel growth and structural integrity...
  10. ncbi Signal transduction in esophageal and LES circular muscle contraction
    K M Harnett
    Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
    Yale J Biol Med 72:153-68. 1999
    ..e., phosphatidylcholine-specific phospholipase C (PC-PLC), phospholipase D (PLD), and the high molecular weight (85 kDa) cytosolic phospholipase A2 (cPLA2) to induce ..
  11. ncbi 5-Hydroxytryptamine receptor-mediated phosphoinositide hydrolysis in canine cultured tracheal smooth muscle cells
    C M Yang
    Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
    Br J Pharmacol 111:777-86. 1994
    ..We therefore investigated the effects of 5-HT on phospholipase C (PLC)-mediated phosphoinositide (PI) hydrolysis and its regulation in canine cultured tracheal smooth muscle cells (..
  12. ncbi Hyperactivation of phospholipase C does not support the enhanced proliferation of aortic smooth muscle cells from spontaneously hypertensive rats
    J L Paquet
    INSERM U7, , Paris, France
    Am J Hypertens 4:651-60. 1991
    ..various agonists tested under the same experimental conditions confirm that the classical pathogenic diagram: (PLC hyperactivation----increase in c-fos transcription----enhanced cell proliferation) may apply to the action of ..
  13. ncbi [Increased phosphorylations of proteins involved in the expression of the physiologic response of platelets in SHR rats]
    S Koutouzov
    , INSERM U 7, , Paris, France
    Arch Mal Coeur Vaiss 83:1317-20. 1990
    In primary hypertension, phospholipase C (PLC) is hypersensitive in several target tissues (platelets, vascular smooth muscle cells, aortic fibroblasts)...
  14. ncbi Vasopressin-stimulated [3H]-inositol phosphate and [3H]-phosphatidylbutanol accumulation in A10 vascular smooth muscle cells
    R Plevin
    Department of Biochemistry, University of Glasgow
    Br J Pharmacol 107:109-15. 1992
    ..Therefore stimulation of PKC may have opposing roles in the regulation of agonist activation of PLC and PLD.7...
  15. ncbi Aging and calcitriol regulation of IP3 production in rat skeletal muscle and intestine
    M M Facchinetti
    Dept. Biologia, Bioquimica and Farmacia, San Juan, Bahia Blanca, Argentina
    Horm Metab Res 33:10-5. 2001
    ..D3] in rat skeletal muscle and duodenum stimulates the hydrolysis of polyphosphoinositides by phospholipase C (PLC), generating the second messengers inositol trisphosphate (IP3) and diacylglycerol (DAG), and that this mechanism ..
  16. ncbi [Role of external calcium on the growth of aortic smooth muscle cells in SHR]
    J L Paquet
    INSERM U 7, , Paris
    Arch Mal Coeur Vaiss 83:1179-82. 1990
    ..FCS-induced PLC activation is equivalent in both types of cells...
  17. ncbi Clinical pattern of cutaneous drug eruption among children and adolescents in north India
    V K Sharma
    Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Pediatr Dermatol 12:178-83. 1995
    ..FDE), 10 erythema multiforme (EM), 6 (12%) toxic epidermal necrolysis (TEN), 5 (10%) Stevens-Johnson syndrome (SJS), 3 (6%) urticaria, and 2 (4%) erythroderma...
  18. ncbi [Correlation between hepatitis B virus infection and chronic liver disease in Okinawa]
    H Sakugawa
    First Department of Internal Medicine, University Hospital, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 66:14-21. 1992
    ..005). In contrast, mortality rates of both liver cirrhosis (LC) and primary liver cancer (PLC) in Okinawa are the lowest in Japan...
  19. ncbi The c-erbA beta thyroid hormone receptor. Expression and cDNA sequence analysis of the hormone-binding domain in human cancer cell lines
    V T Chow
    Department of Microbiology, Faculty of Medicine, National University of Singapore, Kent Ridge
    Acta Oncol 33:499-505. 1994
    ..significant expression of the c-erbA beta gene was detected in the SiHa, CaSki, HeLa cervical carcinoma; Hep3B, PLC/PRF/5, Mahlavu hepatocellular carcinoma; HT-1080 fibrosarcoma cell lines; as well as in normal MRC-5 embryo lung ..
  20. ncbi Quantitative comparisons of muscarinic and bradykinin receptor-mediated Ins (1,4,5)P3 accumulation and Ca2+ signalling in human neuroblastoma cells
    G B Willars
    Department of Cell Physiology and Pharmacology, University of Leicester
    Br J Pharmacol 114:1133-42. 1995
    ..Agonist potencies were unaffected by lowering [Ca2+]e. Thus, a consistent but small amount of PLC activity during rapid activation appears to be sensitive to lowered [Ca2+]e, whilst activity during sustained ..
  21. ncbi Protein A-activated rat splenic lymphocyte proliferation involves tyrosine kinase-phospholipase C-protein kinase C pathway
    T Das
    Immunotechnology Section, Bose Institute, Calcutta, India
    Immunopharmacol Immunotoxicol 22:75-90. 2000
    ..splenic lymphocytes in a dose dependent manner and stimulates proliferation via tyrosine kinase-phospholipase C (PLC)-Ca2+-dependent protein kinase C (PKC) pathway...
  22. ncbi Diacylglycerol generated by exogenous phospholipase C activates the mitogen-activated protein kinase pathway independent of Ras- and phorbol ester-sensitive protein kinase C: dependence on protein kinase C-zeta
    M van Dijk
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Biochem J 323:693-9. 1997
    ..the plasma membrane by treating Rat-1 fibroblasts with bacterial phosphatidylcholine-specific phospholipase C (PC-PLC). This treatment leads to activation of mitogen-activated protein kinase (MAPK)...
  23. ncbi The signal transducer for the dopamine-1 regulated sodium transport in renal cortical brush border membrane vesicles
    C C Felder
    Section on Pharmacology, National Institute of Mental Health, Bethesda, Maryland
    Am J Hypertens 3:47S-50S. 1990
    ..DA-1 agonists stimulate adenylate cyclase (AC) and phospholipase C (PLC) activity in both membranes...
  24. ncbi [Molecular mechanisms controlling the proliferation of aortic smooth muscle cells in spontaneously hypertensive rats]
    J L Paquet
    INSERM U 7, , Paris
    Arch Mal Coeur Vaiss 82:1319-21. 1989
    ..However other molecular processes may be involved, as suggested by the growth inhibition exerted by heparin without any action on PLC activity.
  25. ncbi Signaling through CD5 involves acidic sphingomyelinase, protein kinase C-zeta, mitogen-activated protein kinase kinase, and c-Jun NH2-terminal kinase
    M Simarro
    Servei d'Immunologia, , , Barcelona, Spain
    J Immunol 162:5149-55. 1999
    ..biochemical events triggered by CD5 stimulation, which include the phosphatidylcholine-specific phospholipase C (PC-PLC)-dependent activation of acidic sphingomyelinase (A-SMase) in normal and lymphoblastoid T and B cells...
  26. ncbi Enhanced proliferating activity of cultured smooth muscle cells from SHR
    J L Paquet
    Department of Pharmacology, Hopital Necker, Paris, France
    Am J Hypertens 2:108-10. 1989
    ..was determined by cell counting and measurement of nuclear-tritiated thymidine incorporation and phospholipase C (PLC) activation by measurement of 3h-inositol mono-, di-, tri-, and tetra-phosphates formed from preincorporated 3h-myo-..
  27. ncbi Assessment of cell culture and polymerase chain reaction procedures for the detection of polioviruses in wastewater
    W O Grabow
    Department of Medical Virology, University of Pretoria, South Africa
    Bull World Health Organ 77:973-80. 1999
    ..Optimal isolation of polioviruses was accomplished by parallel inoculation of L20B mouse cells and at least the PLC/PRF/5 human liver and buffalo green monkey (BGM) kidney cell lines...
  28. ncbi Application of capillary electrophoresis to determination of enzyme activity and other properties of phosphatidylinositol-specific phospholipase C
    M J Suh
    Doping Control Center, Korea Institute of Science and Technology, Seoul, South Korea
    J Chromatogr A 781:263-70. 1997
    ..MEKC is used to analyze the activity of phosphatidylinositol-specific phospholipase C (PI-PLC) with convenience and precision...
  29. ncbi Ocular surface inflammation mediated by innate immunity
    Mayumi Ueta
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan
    Eye Contact Lens 36:269-81. 2010
    ..of the ocular surface epithelium, innate immunity and ocular surface inflammation, and Stevens-Johnson syndrome (SJS) and abnormality of innate immunity...
  30. ncbi Platelet-derived growth factor activation of mitogen-activated protein kinase depends on the sequential activation of phosphatidylcholine-specific phospholipase C, protein kinase C-zeta and Raf-1
    M C Van Dijk
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Biochem J 325:303-7. 1997
    ..previously reported that, in Rat-1 fibroblasts, PDGF activates a phosphatidylcholine-specific phospholipase C (PC-PLC) and that the product, diacylglycerol, somehow activates protein kinase C-zeta (PKC-zeta)...
  31. ncbi The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study
    Susan Shur Fen Gau
    Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
    J Clin Psychopharmacol 28:509-17. 2008
    ..carbamazepine and valproate) and other medications (including other anticonvulsants) and the risks of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) among patients with bipolar disorder.
  32. ncbi Phosphatidic acid regulates signal output by G protein coupled receptors through direct interaction with phospholipase C-beta(1)
    Irene Litosch
    Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
    Cell Signal 21:1379-84. 2009
    ..phospholipase D (PLD) and additionally by diacylglycerol kinases (DGK), both stimulates phospholipase C-beta(1) (PLC-beta(1)) and potentiates stimulation of PLC-beta(1) activity by Galpha(q) in vitro...
  33. ncbi Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population
    Wichittra Tassaneeyakul
    Departments of Pharmacology, Khon Kaen University, Khon Kaen, Thailand
    Pharmacogenet Genomics 19:704-9. 2009
    ..reported as a common cause of severe cutaneous adverse drug reactions (SCAR) including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)...
  34. ncbi High-dose intravenous immunoglobulins in the treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese patients: a retrospective study of 82 cases
    Jinbo Chen
    Department of Dermatology, Peking Union Medical College, Beijing, 100730, China
    Eur J Dermatol 20:743-7. 2010
    Stevens-Johnson Syndrome (SJS) and Toxic epidermal necrolysis (TEN) are drug-induced diseases with a low incidence but high mortality...
  35. ncbi Identification and characterization of novel microRNAs from Schistosoma japonicum
    Xiangyang Xue
    Institute for Infectious Diseases and Vaccine Development, Tongji University School of Medicine, Shanghai, China
    PLoS ONE 3:e4034. 2008
    ..Although a large number of miRNAs have been identified from plants to mammals, it remains no experimental proof whether schistosome exist miRNAs...
  36. ncbi Activation of host phospholipases C and D in macrophages after infection with Listeria monocytogenes
    H Goldfine
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6076, USA
    Infect Immun 68:5735-41. 2000
    ..result from the actions of secreted bacterial proteins, including phosphatidylinositol-specific phospholipase C (PI-PLC), a broad-range phospholipase C, and listeriolysin O (LLO) (S. J. Wadsworth and H. Goldfine, Infect. Immun...
  37. ncbi Comparison of two different preparations of ibuprofen with regard to the time course of their analgesic effect. A randomised, placebo-controlled, double-blind cross-over study using laser somatosensory evoked potentials obtained from UW-irritated skin in
    Klaus Seibel
    HPR Human Pharmacodynamic Research GmbH, Munich, Germany
    Arzneimittelforschung 54:444-51. 2004
    ..of Dolormin as a single dose) in comparison with standard Ibu tablets (two tablets as a single dose) and placebo (Plc) utilising the objective, quantitative (high resolution) method of Laser algesimetry...
  38. ncbi Role of lipid packing in the activity of phospholipase C-delta1 as determined by hydrostatic pressure measurements
    M Rebecchi
    Department of Anesthesiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Biochem J 341:571-6. 1999
    ..monolayers revealed a large decrease in the activity of phosphoinositide-specific phospholipase C-delta(1) (PLC-delta(1)) which catalyses the hydrolysis of PtdIns(4, 5)P(2) as lateral pressure is applied to the membrane...
  39. ncbi A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs
    Christine Lonjou
    INSERM, U563 Paul Sabatier University III, Toulouse, France
    Pharmacogenet Genomics 18:99-107. 2008
    Stevens-Johnson syndrome (SJS) and its severe form, toxic epidermal necrolysis (TEN), are rare but life-threatening cutaneous adverse reactions to drugs, especially to allopurinol, carbamazepine, lamotrigine, phenobarbital, phenytoine, ..
  40. ncbi Analysis of platelet-derived growth factor-induced phospholipase D activation in mouse embryo fibroblasts lacking phospholipase C-gamma1
    J A Hess
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0295, USA
    J Biol Chem 273:20517-24. 1998
    ..In order to investigate a role for phospholipase C-gamma1 (PLC-gamma1), we used targeted disruption of the Plcg1 gene in the mouse to develop Plcg1(+/+) and Plcg1(-/-) cell lines...
  41. ncbi Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions
    Shuen Iu Hung
    Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei, Taiwan
    Pharmacogenet Genomics 16:297-306. 2006
    ..cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)...
  42. ncbi Purification and G protein subunit regulation of a phospholipase C-beta from Xenopus laevis oocytes
    T M Filtz
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 271:31121-6. 1996
    ..Premont, R. T., Landau, E. M., and Iyengar, R. J. Biol. Chem. 268, 19915-19918) cloned a Xenopus phospholipase C (PLC-betaX) that exhibits homology to the PLC-beta class of isoenzymes...
  43. ncbi Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux
    J R Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    Biochemistry 39:15199-207. 2000
    ..phosphatidylcholine-specific phospholipases C and D (PC-PLs) and phosphatidylinositol-specific phospholipase C (PI-PLC). However, only activation of PC-PLs was linked to the HDL-induced cholesterol efflux...
  44. ncbi The natural history of Stevens Johnson syndrome: patterns of chronic ocular disease and the role of systemic immunosuppressive therapy
    M Victoria De Rojas
    Moorfields Eye Hospital, 162 City Road, London EC1V 2PD, UK
    Br J Ophthalmol 91:1048-53. 2007
    To characterize patterns of chronic ocular disease in patients with Stevens-Johnson syndrome (SJS) and its variant toxic epidermal necrolysis (TEN), and to describe their response to treatment.
  45. ncbi The impact of total body photography on biopsy rate in patients from a pigmented lesion clinic
    Jessica Risser
    Department of Dermatology, Emory University, Atlanta, GA 30322, USA
    J Am Acad Dermatol 57:428-34. 2007
    ....
  46. ncbi Severe adverse skin reactions to nonsteroidal antiinflammatory drugs: A review of the literature
    Kristina E Ward
    College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA
    Am J Health Syst Pharm 67:206-13. 2010
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs) are described.
  47. ncbi Expression of Mycobacterium leprae 18-kDa antigen in yeast in a GPI-anchored form
    A G Amorim
    Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, , Brasil
    Braz J Med Biol Res 27:623-6. 1994
    ..In addition, these cells react with an alpha-CRD antibody after GPI-PLC treatment. The non-transformed cells are negative...
  48. ncbi Phospholipase C-beta4 is essential for the progression of the normal sleep sequence and ultradian body temperature rhythms in mice
    Masayuki Ikeda
    Department of Chronobiology, Graduate School of Innovative Life Science, University of Toyama, Toyama, Japan
    PLoS ONE 4:e7737. 2009
    ..e., narcolepsy) in orexin-deficient mutant animals. Phospholipase C (PLC) mediates the signaling of numerous metabotropic receptors, including orexin receptors...
  49. ncbi Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity
    Jong Soo Chang
    Department of Life Science, College of Natural Science, Daejin University, Kyeonggido 487 711, Korea
    J Biol Chem 277:19697-702. 2002
    ..Phospholipase C (PLC)-gamma1 has two putative PH domains, an NH(2)-terminal and a split PH domain...
  50. ncbi Requirement of the Listeria monocytogenes broad-range phospholipase PC-PLC during infection of human epithelial cells
    ANGELIKA GRUNDLING
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115 6092, USA
    J Bacteriol 185:6295-307. 2003
    In this study, we investigated the requirement of the Listeria monocytogenes broad-range phospholipase C (PC-PLC) during infection of human epithelial cells. L...
  51. ncbi Glycosylphosphatidylinositol-specific phospholipase C regulates transferrin endocytosis in the African trypanosome
    Sandesh Subramanya
    Department of Cellular Biology, University of Georgia, 724 Biological Sciences Building, Athens, GA 30602, USA
    Biochem J 417:685-94. 2009
    GPI-PLC (glycosylphosphatidylinositol-specific phospholipase C) is expressed in bloodstream-form Trypanosoma brucei, a protozoan that causes human African trypanosomiasis...
  52. ncbi Paucicellular lymphocytic colitis: is it a minor form of lymphocytic colitis? A clinical pathological and immunological study
    Fernando Fernández-Bañares
    Department of Gastroenterology, Hospital Mutua Terrassa, Universitat de Barcelona, Terrassa, Barcelona, Spain
    Am J Gastroenterol 104:1189-98. 2009
    It has been suggested that paucicellular lymphocytic colitis (PLC) should be considered to be part of the morphological spectrum of microscopic colitis...
  53. ncbi [Expressions of epidermal growth factor receptor signaling substances in gastric mucosal cells influenced by serum derived from rats treated with electroacupuncture at stomach meridian acupoints]
    Jie Yan
    College of Acupuncture and Massage, Hunan University of Traditional Chinese Medicine, Changsha, Hunan Province 410007, China
    Zhong Xi Yi Jie He Xue Bao 5:338-42. 2007
    ..with electroacupuncture at stomach meridian acupoints on the expressions of epidermal growth factor receptor (EGFR) signaling substances phospholipase C gamma-1 (PLC gamma-1), protein kinase C (PKC) and c-myc in gastric mucosal cells.
  54. ncbi Fatal toxic epidermal necrolysis associated with minoxidil
    Lamis R Karaoui
    Pharmacy Department, Saint Michael s Medical Center, Newark, New Jersey 07102, USA
    Pharmacotherapy 29:460-7. 2009
    ..its powerful antihypertensive effect, and less frequently, rashes, bullous eruptions, and Stevens-Johnson syndrome (SJS)...
  55. ncbi Diacylglycerol generated in CHO cell plasma membrane by phospholipase C is used for triacylglycerol synthesis
    R A Igal
    Instituto de Investigaciones Bioquimicas de La Plata, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina
    J Lipid Res 42:88-95. 2001
    ..TAG), we studied the direct formation of TAG from endogenous DAG generated by bacterial phospholipase C (PLC)...
  56. ncbi The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase
    Christine Tkaczyk
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:48474-84. 2003
    ..is generally believed to be dependent on phosphatidylinositide 3-kinase (PI 3-kinase)-mediated phospholipase C (PLC)gamma activation...
  57. ncbi [A 25-year-old woman with primary Sjögren syndrome who developed optic neuritis and encephalomyelitis associated with an anti-aquaporin 4 antibody]
    Hirotaka Kato
    Department of Neurology, Showa University School of Medicine
    Rinsho Shinkeigaku 49:576-81. 2009
    ..a 25-year-old woman who developed optic neuritis and encephalomyelitis following primary Sjögren's syndrome (SjS)...
  58. ncbi Targeting of protein kinase C-epsilon during Fcgamma receptor-dependent phagocytosis requires the epsilonC1B domain and phospholipase C-gamma1
    Keylon L Cheeseman
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
    Mol Biol Cell 17:799-813. 2006
    ..The role of phospholipase D (PLD), phosphatidylinositol-specific phospholipase C (PI-PLC)-gamma1, and PI-PLC-gamma2 in PKC-epsilon accumulation was assessed...
  59. ncbi Phylogenetic analysis of phospholipase C genes from Clostridium perfringens types A to E and Clostridium novyi
    K Tsutsui
    Third Department of Internal Medicine, Kagawa Medical School, Japan
    J Bacteriol 177:7164-70. 1995
    ..perfringens were examined by analysis of differences in the nucleotide sequences of phospholipase C genes (plc genes) among 10 strains, including 3 strains for which the plc gene sequences have been previously reported...
  60. ncbi Cloning and characterization of a gene encoding phosphatidyl inositol-specific phospholipase C from Trypanosoma cruzi
    T Nozaki
    Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan
    Mol Biochem Parasitol 102:283-95. 1999
    A gene encoding phosphatidyl inositol-4,5-bisphosphate phospholipase C (PLC) was cloned from the protozoan parasite Trypanosoma cruzi...
  61. ncbi Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets
    B S Gross
    Department of Pharmacology, University of Oxford, UK
    Eur J Biochem 263:612-23. 1999
    ..which is part of the collagen receptor glycoprotein VI, the tyrosine kinase Syk and phospholipase C-gamma2 (PLC-gamma2)...
  62. ncbi HLA class I and II gene polymorphisms in Stevens-Johnson syndrome with ocular complications in Japanese
    Mayumi Ueta
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Mol Vis 14:550-5. 2008
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute-onset mucocutaneous diseases induced by infectious agents and/or inciting drugs...
  63. ncbi Xylem embolism alleviated by ion-mediated increase in hydraulic conductivity of functional xylem: insights from field measurements
    Patrizia Trifilò
    Dipartimento di Scienze della Vita M Malpighi, Universita di Messina, Salita Sperone 31, 98166 Messina S Agata, Italy
    Tree Physiol 28:1505-12. 2008
    ..tested whether this ionic effect partly compensates for the embolism-induced loss of stem hydraulic conductivity (PLC) by increasing K(h) of functioning conduits...
  64. ncbi Atrial natriuretic peptide-C receptor-induced attenuation of adenylyl cyclase signaling activates phosphatidylinositol turnover in A10 vascular smooth muscle cells
    Rima Mouawad
    Department of Physiology, Faculty of Medicine, University of Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, Canada, H3C 3J7
    Mol Pharmacol 65:917-24. 2004
    ..activation has been shown to inhibit adenylyl cyclase (AC) activity as well as to stimulate phospholipase C (PLC) signaling pathways...
  65. ncbi Association study of lamotrigine-induced cutaneous adverse reactions and HLA-B*1502 in a Han Chinese population
    Dong mei An
    Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
    Epilepsy Res 92:226-30. 2010
    ..HLA)-B*1502 has been strongly associated with CBZ-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)...
  66. ncbi Phospholipase C-delta1 modulates sustained contraction of rat mesenteric small arteries in response to noradrenaline, but not endothelin-1
    Christopher J Clarke
    Cardiovascular Research Group, School of Clinical and Laboratory Science, Univ of Manchester, Core Technology Facility 3floor 46 Grafton St, Manchester M13 9NT, UK
    Am J Physiol Heart Circ Physiol 295:H826-34. 2008
    Vasoconstrictors activate phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP(2)), leading to calcium mobilization, protein kinase C activation, and contraction...
  67. ncbi Acute renal failure and its risk factors in Stevens-Johnson syndrome and toxic epidermal necrolysis
    Chi Chih Hung
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Am J Nephrol 29:633-8. 2009
    ..We thus investigated the renal outcome of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), the most severe drug-induced cutaneous hypersensitivity, and hypothesize ..
  68. ncbi Prevention of highly emetogenic chemotherapy-induced vomiting: a double blind, randomized crossover study to compare pancopride (LAS 30451) and pancopride plus dexamethasone
    E Aranda
    Medical Oncology Department, University Hospital Reina Sofia, , Spain
    Tumori 81:432-4. 1995
    ..METHODS: PNC (0.2 mg/kg. i.v. 30 min before chemotherapy) plus placebo (PLC) was compared with PNC (same dose and schedule) plus DXM (20 mg. i.v. immediately before PNC)...
  69. ncbi Comparison of diagnostic accuracy for cutaneous malignant melanoma between general dermatology, plastic surgery and pigmented lesion clinics
    J E Osborne
    Department of Dermatology, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Br J Dermatol 148:252-8. 2003
    Since the 1980s there have been dedicated pigmented lesion clinics (PLCs) in the U.K. Important considerations when comparing the efficacy of the PLC with other referral clinics include diagnostic accuracy.
  70. ncbi Solution conformations of short-chain phosphatidylcholine. Substrates of the phosphatidylcholine-preferring PLC of Bacillus cereus
    S F Martin
    Department of Chemistry and Biochemistry, University of Texas, Austin, TX 78712, USA
    Biochim Biophys Acta 1464:104-12. 2000
    The phosphatidylcholine (PC)-preferring phospholipase C (PLC) from Bacillus cereus (PLC(Bc)) hydrolyzes various 1,2-diacyl derivatives of PC at different rates...
  71. ncbi Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis during first weeks of antiepileptic therapy: a case-control study. Study Group of the International Case Control Study on Severe Cutaneous Adverse Reactions
    B Rzany
    Department of Dermatology, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany
    Lancet 353:2190-4. 1999
    ..about whether all antiepileptic drugs are associated with the severe cutaneous reactions Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)...
  72. ncbi Tolbutamide and diazoxide modulate phospholipase C-linked Ca(2+) signaling and insulin secretion in beta-cells
    C Schofl
    Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Am J Physiol Endocrinol Metab 278:E639-47. 2000
    ..free Ca(2+) and potentiate glucose-induced insulin release by activating receptors linked to phospholipase C (PLC)...
  73. ncbi Regulation of phospholipase C-beta activity by phosphatidic acid: isoform dependence, role of protein kinase C, and G protein subunits
    Irene Litosch
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Biochemistry 42:1618-23. 2003
    Phosphatidic acid (PA) stimulates phospholipase C-beta(1) (PLC-beta(1)) activity and promotes G protein stimulation of PLC-beta(1) activity...
  74. ncbi Association of HLA-B*1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population
    Choong Chor Chang
    Department of Dermatology, Kuala Lumpur Hospital Allergy and Immunology Research Center, Kuala Lumpur, Malaysia
    Int J Dermatol 50:221-4. 2011
    ..cutaneous adverse drug reactions such as toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS)...
  75. ncbi Calcium-sensing receptor-mediated activation of phospholipase C-gamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts
    S L Godwin
    Department of Orthodontics, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 30:559-66. 2002
    ..Ca(e)-mediated chemotaxis of these bone-forming cells is dependent on phospholipase C (PLC) and blocked by the Gi-protein inhibitor pertussis toxin...
  76. ncbi [Stevens-Johnson syndrome and toxic epidermal necrolysis in Lomé (Togo). Evolutional and etiological profiles of 40 cases]
    P Pitche
    Service de Dermatologie, Réanimation des brûlés, CHU Tokoin, Lome, Togo
    Ann Dermatol Venereol 132:531-4. 2005
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous drug reactions, the prognosis of which largely depends on the quality of their treatment...
  77. ncbi Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1
    Catharina W Wieland
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Infect Immun 70:1352-8. 2002
    ..P. aeruginosa lipopolysaccharide (LPS), phosholipase C (PLC), and exotoxin A (ETA) were evaluated for their ability to induce pulmonary inflammation in mice following ..
  78. ncbi Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain
    Kazuki Nagasawa
    Department of Environmental Biochemistry, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina, Kyoto 607 8414, Japan
    Life Sci 73:1453-62. 2003
    ..that hyperoxia exerts oxidative stress on the rat cerebral cortex, and the protein levels of phospholipase C (PLC) -beta1 and -delta1, but not PLC-gamma1, were changed...
  79. ncbi Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes
    T Pawelczyk
    Department of Molecular Medicine, Medical University of Gdansk, Poland
    Eur J Biochem 262:291-8. 1999
    In order to acquire an understanding of phospholipase C-delta3 (PLC-delta3) action on substrate localized in lipid membrane we have studied the binding of human recombinant PLC-delta3 to large, unilamellar phospholipid vesicles (LUVs)...
  80. ncbi pH-regulated activation and release of a bacteria-associated phospholipase C during intracellular infection by Listeria monocytogenes
    H Marquis
    Department of Microbiology, University of Colorado Health Sciences Center, School of Medicine Box B 175, 4200 E 9th Avenue, Denver, CO 80262, USA
    Mol Microbiol 35:289-98. 2000
    ..Escape from these vacuoles is mediated in part by a bacterial phospholipase C (PC-PLC), whose activation requires cleavage of an N-terminal peptide...
  81. ncbi [Stevens-Johnson syndrome, toxic epidermal necrolysis and phenytoin. Factors linked to a higher risk]
    M S Gómez-Criado
    Departamento de Farmacovigilancia, Pfizer España, Madrid, Spain
    Rev Neurol 38:1056-60. 2004
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe, although not very common, clinical skin pictures that are usually related to the use of medication...
  82. ncbi Combination therapy of intravenous immunoglobulin and corticosteroid in the treatment of toxic epidermal necrolysis and Stevens-Johnson syndrome: a retrospective comparative study in China
    Yongsheng Yang
    Department of Dermatology, Affiliated Huashan Hospital, Fudan University, Shanghai, China
    Int J Dermatol 48:1122-8. 2009
    Toxic epidermal necrolysis (TEN) and Stevens-Johnson Syndrome (SJS) are drug-induced diseases with no well-established treatments. The application of corticosteroid therapy is controversial...
  83. ncbi Diagnostic accuracy of primary liver cancer: implications for cancer registration
    F Donato
    Cattedra di Igiene, , Italy
    Tumori 81:86-90. 1995
    ..some standardized criteria for classifying incident cases of liver cancer into either primary liver cancer (PLC) or unspecified liver cancer (ULC) on the basis of the diagnostic examinations performed and their results...
  84. ncbi Arabidopsis type-III phosphatidylinositol 4-kinases ?1 and ?2 are upstream of the phospholipase C pathway triggered by cold exposure
    Elise Delage
    CNRS, EAC7180, Physiologie Cellulaire et Moléculaire des Plantes, Paris and UPMC Univ Paris 06, UR5, Physiologie Cellulaire et Moléculaire des Plantes, Paris, France
    Plant Cell Physiol 53:565-76. 2012
    ..This lipid is the substrate of phosphoinositide-dependent phospholipase C (PI-PLC) that produces diacylglycerol (DAG) which can be phosphorylated to phosphatidic acid (PtdOH)...
  85. ncbi Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population
    Chaichon Locharernkul
    Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Epilepsia 49:2087-91. 2008
    ..studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations...
  86. ncbi Identification and characterization of a new phospholipase C-like protein, PLC-L(2)
    M Otsuki
    Department of Biochemistry, Institute of Medical Science, University of Tokyo, Japan
    Biochem Biophys Res Commun 266:97-103. 1999
    We have isolated a cDNA encoding a novel protein, PLC-L(2), with homology to the phospholipase C-like protein PLC-L and delta-type phospholipase C...
  87. ncbi Recurrence patterns in patients with early stage non-small cell lung cancers undergoing positive pleural lavage cytology
    Yukitoshi Satoh
    Department of Thoracic Surgical Oncology, Cancer Institute Hospital, Tokyo, Japan
    Ann Thorac Surg 83:197-202. 2007
    Cytologic approaches such as pleural lavage cytology (PLC) are considered as possible aids to assessing prognosis of lung cancers...
  88. ncbi Compartmentalization of the broad-range phospholipase C activity to the spreading vacuole is critical for Listeria monocytogenes virulence
    P S Marie Yeung
    Department of Microbiology and Immunology, Cornell University, VMC C5 169, Ithaca, NY 14853 6401, USA
    Infect Immun 75:44-51. 2007
    ..The broad-range phospholipase C (PC-PLC) of L. monocytogenes contributes to bacterial escape from vacuoles formed upon cell-to-cell spread...
  89. ncbi Differential gene expressions in the lacrimal gland during development and onset of keratoconjunctivitis sicca in Sjögren's syndrome (SJS)-like disease of the C57BL/6.NOD-Aec1Aec2 mouse
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Exp Eye Res 88:398-409. 2009
    ..These two genetic regions confer Sjögren's syndrome (SjS)-like disease in SjS-non-susceptible C57BL/6 mice...
  90. ncbi Reduced perlecan expression and accumulation in human carotid atherosclerotic lesions
    Phan Kiet Tran
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Atherosclerosis 190:264-70. 2007
    ..Analysis of the specimens by gene microarray showed a selective reduction in perlecan gene expression, whereas, expression of the other heparan sulfate proteoglycans in the artery wall, agrin and ..
  91. ncbi GTPgammaS antagonizes the mastoparan-induced in vitro activity of PIP-phospholipase C from symbiotic root nodules of Phaseolus vulgaris
    César De Los Santos-Briones
    Centro de Investigación Científica de Yucatán, Merida, Mexico
    Physiol Plant 135:237-45. 2009
    Phospholipase C (PLC) has been suggested to have a role in signal perception by Nod factors (NFs) in legume root hair cells...
  92. ncbi IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    J Immunol 179:382-90. 2007
    NOD.B10-H2(b) and NOD/LtJ mice manifest, respectively, many features of primary and secondary Sjögren's syndrome (SjS), an autoimmune disease affecting primarily the salivary and lacrimal glands leading to xerostomia (dry mouth) and ..
  93. ncbi Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene
    E Arikawa-Hirasawa
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 27:431-4. 2001
    b>Perlecan is a large heparan sulfate (HS) proteoglycan present in all basement membranes and in some other tissues such as cartilage, and is implicated in cell growth and differentiation...
  94. ncbi Molecular cloning, expression and regulatory activity of G alpha 11- and beta gamma-subunit-stimulated phospholipase C-beta from avian erythrocytes
    G L Waldo
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill 27599 7365, USA
    Biochem J 316:559-68. 1996
    A turkey erythrocyte phospholipase C (PLC) has been instrumental in delineating the role of G-proteins in receptor-regulated inositol lipid signalling...
  95. ncbi Activation of PLC and PI 3 kinase by PDGF receptor alpha is not sufficient for mitogenesis and migration in mesangial cells
    G G Choudhury
    Department of Medicine, University of Texas Health Science Center, San Antonio, USA
    Kidney Int 57:908-17. 2000
    ..In this study, we investigated the effect of PDGF AA on cell migration, PI 3 kinase and phospholipase C (PLC) activation, and the role of these two enzymes in mediating biological responses in these cells in response to all ..
  96. ncbi Is there a way to diagnose spinal instability in acute burst fractures by performing ultrasound?
    T Vordemvenne
    Department of Trauma and Reconstructive Surgery, University of Munster, Waldeyer Strasse1, 48149, Munster, Germany
    Eur Spine J 18:964-71. 2009
    ..value of ultrasound diagnostics for the assessment of traumatic lesions of the posterior ligament complex (PLC) in burst fractures of the thoracolumbar spine. This was a prospective validating cohort study...
  97. ncbi The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors
    Jadee L Upshaw
    Department of Immunology, and Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Immunol 175:213-8. 2005
    The two isoforms of phospholipase C (PLC)-gamma couple immune recognition receptors to important calcium- and protein kinase C-dependent cellular functions...
  98. ncbi Two waves of the nuclear phospholipase C activity in serum-stimulated HL-60 cells during G(1) phase of the cell cycle
    Vesna Lukinovic-Skudar
    Department of Physiology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 3, Zagreb, Croatia
    Biochim Biophys Acta 1771:514-21. 2007
    Phosphatidylinositol-specific phospholipase C (PI-PLC) is activated in cell nuclei during the cell cycle progression...
  99. ncbi Identification of possible candidate genes regulating Sjögren's syndrome-associated autoimmunity: a potential role for TNFSF4 in autoimmune exocrinopathy
    Cuong Q Nguyen
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    Arthritis Res Ther 10:R137. 2008
    Sjögren syndrome (SjS) is a systemic autoimmune disease in which an immunological attack primarily against the salivary and lacrimal glands results in the loss of acinar cell tissue and function, leading to stomatitis sicca and ..
  100. ncbi Catalytic activity of nuclear PLC-beta(1) is required for its signalling function during C2C12 differentiation
    Giulia Ramazzotti
    Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, 40126 Bologna, Italy
    Cell Signal 20:2013-21. 2008
    Here we report that PLC-beta(1) catalytic activity plays a role in the increase of cyclin D3 levels and induces the differentiation of C2C12 skeletal muscle cells...

Research Grants93

  1. ACTIVATION OF PI-SPECIFIC PHOSPHOLIPASE C ENZYMES
    Mary Roberts; Fiscal Year: 2003
    ..Since PI-PLC enzymes are water-soluble and their normal substrates, phosphoinositides, are localized in membranes, their ..
  2. ACTIVATION OF PI-SPECIFIC PHOSPHOLIPASE C ENZYMES
    Mary Roberts; Fiscal Year: 2007
    ..activator of protein kinase C), and inositol phosphates (cyclic 1,2-inositol phosphate in the case of bacterial PI-PLC and both cIP and inositol-1-phosphate from PI for mammalian Pl-PLC isozymes)...
  3. Activation of PI Specific Phospholipase C Enzymes
    MARY FEDARKO ROBERTS; Fiscal Year: 2010
    Mammalian phosphatidylinositol specific phospholipase C (PI-PLC) enzymes are multidomain proteins that are key regulators of phosphoinositide-signaling, They have critical roles in cell growth and proliferation...
  4. Mechanism for Regulation of Phospholipase C by G Protein
    Alan Smrcka; Fiscal Year: 2005
    Hydrolysis of phosphatidylinositol 4,5 bisphosphate by phosphatidylinositol-specific phospholipase C (PLC) is a central process in hormone regulation of cellular physiology in virtually all mammalian tissues...
  5. GPI PHOSPHOLIPASE C OF T BRUCEI
    Kojo Mensa Wilmot; Fiscal Year: 2001
    ..T. brucei expresses a phospholipase C (GPI-PLC) which cleaves GPIs with high efficiency...
  6. LIPID-PROTEIN INTERACTIONS
    O Griffith; Fiscal Year: 1992
    ..b) Mapping of the lipid binding region of phosphatidylinositol-specific phospholipase C (PI-PLC). PI-PLC cleaves and PI into two parts: lipid-soluble diacylglycerol (DG) and water-soluble inositol phosphate...
  7. PHOSPHOLIPASE C AND ISLET BETA CELLS
    GRANT KELLEY; Fiscal Year: 2002
    Phosphatidylinositol-specific phospholipase C (PLC) plays an important role in the regulation of insulin secretion by diverse nutrient and hormone secretagogues...
  8. REGULATION OF PHOSPHOLIPASE C
    John Sondek; Fiscal Year: 2007
    ..occur either through heptahelical receptors coupled to heterotrimeric G proteins that activate phospholipase C-J3 (PLC-13) isozymes or through tyrosine kinase-activating receptors producing SH2 domain-dependent activation of PLC-'/...
  9. REGULATION OF PHOSPHOLIPASE C
    John Sondek; Fiscal Year: 2007
    ..either through heptahelical receptors coupled to heterotrimeric G proteins that activate phospholipase C-beta (PLC-beta) isozymes or through tyrosine kinase-activating receptors producing SH2 domain-dependent activation of PLC-..
  10. SIGNAL TRANSDUCTION DEFECTS IN HUMAN PLATELETS
    A Rao; Fiscal Year: 2006
    ..unrecognized deficiencies in two major platelet proteins involved in signal transduction, phospholipase C-beta2 (PLC-beta2) and the GTP-binding protein Galphaq...
  11. Anaerobic Bacteria as Oncopathic Agents for Pancreatic Cancer
    Savio Woo; Fiscal Year: 2009
    ..We have deleted its alpha toxin gene that encodes phospholipase c (Cp/plc-), and showed that the mutant strain can no longer cause gas gangrene in mice...
  12. STRUCTURE/FUNCTION OF PI-SPECIFIC PHOSPHOLIPASE C
    O Griffith; Fiscal Year: 2001
    Phosphoinositide-specific phospholipase C (PI-PLC) isozymes play a central role in receptor-mediated signal transduction in mammalian cells, cleaving the membrane lipid phosphatidylinositol 4,5-biphosphate to generate two second ..
  13. Regulation of TRP channels and visual transduction by PIs
    Craig Montell; Fiscal Year: 2010
    ..Drosophila phototransduction functions through a phospholipase C (PLC)-dependent signaling system, and culminates in Ca2+ and Na+ influx, via TRP channels...
  14. STRUCTURE/FUNCTION OF SIGNAL TRANSDUCING COMPONENTS
    SRINIVAS RAVI IYENGAR; Fiscal Year: 1999
    ..alpha and beta gamma subunits regulate the activities of effectors such as adenylyl cyclase(AC), phospholipase C(PLC) and K+ channels...
  15. MICROTUBULE-BASED TRANSPORT IN LACRIMAL GLAND FUNCTION
    Sarah F Hamm Alvarez; Fiscal Year: 2010
    ..KCS can occur with the systemic autoimmune disease, Sjogren's syndrome (SjS), or independently...
  16. REGULATION OF PHOSPHOLIPASE C
    T Harden; Fiscal Year: 2002
    ..This response for most receptors involves activation of a G-protein, which in turn activates phospholipase C (PLC)...
  17. Multiple Mechanisms of Nasal Chemoreception
    DIEGO contact RESTREPO; Fiscal Year: 2010
    ..our proposal on our finding that the transient receptor channel M5 (TRPM5), an effector in the phospholipase C (PLC) pathway, is expressed in a subset of olfactory sensory neurons in the main olfactory epithelium whose axons ..
  18. Tyrosine Kinases in Renal Vasoconstrictor Signaling
    PAMELA CARMINES; Fiscal Year: 2007
    ..vasoconstriction via engagement of AT1 receptors (AT1R), which provoke G protein-mediated phospholipase C (PLC) activation and the rise in intracellular Ca2+ concentration ([Ca2+]i) that fuels activation of the contractile ..
  19. MECHANISMS OF ENDOSOME TO LYSOSOME TRANSPORT IN YEAST
    Thomas Vida; Fiscal Year: 2005
    ..genetics and inadequate understanding remains in transfer of proteins from the pre- lysosomal compartment (PLC) to the lysosome...
  20. Escape of Bacillus anthracis from the phagsome
    Howard Goldfine; Fiscal Year: 2004
    ..vacuole of a macrophage using listeriolysin O (LLO) and a phosphatidylinositol-specific phospholipase C (PI-PLC). Genes orthologous to LLO and PI-PLC have recently been discovered in Ba by the genome sequencing project...
  21. GLYCOSPHINGOLIPID METABOLISM AND MENTAL RETARDATION
    Glyn Dawson; Fiscal Year: 2000
    ..The two major Specific Aims are: 1) To understand how receptors are coupled to the activation of phospholipase C (PLC) and the hydrolysis of phosphoinositides, and how this system is regulated by protein kinase A, protein kinase C, ..
  22. Mechanism of Transcription Control by Drosophila TAF250
    DAVID WASSARMAN; Fiscal Year: 2006
    ..core promoter surrounding the transcription start site of a gene nucleates assembly of the preinitiation complex (PlC), which contains RNA polymerase II (Pol II) and the general transcription factors TFIIA, TFIIB, TFIIE, TFIIF, and ..