PDE1A

Summary

Gene Symbol: PDE1A
Description: phosphodiesterase 1A, calmodulin-dependent
Alias: HCAM1, HSPDE1A, 3',5' cyclic nucleotide phosphodiesterase, 61 kDa Cam-PDE, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase, calmodulin-dependent phosphodiesterase, cam-PDE 1A, hCam-1, phosphodiesterase-1A
Species: human

Top Publications

  1. ncbi Variants in PDE11A and PDE1A are not associated with citalopram response
    K S Teranishi
    Mol Psychiatry 12:1061-3. 2007
  2. ncbi Differential effects of tamoxifen-like compounds on osteoclastic bone degradation, H(+)-ATPase activity, calmodulin-dependent cyclic nucleotide phosphodiesterase activity, and calmodulin binding
    J P Williams
    Department of Pathology, University of Alabama at Birmingham 35294, USA
    J Cell Biochem 66:358-69. 1997
  3. ncbi Eburnamine derivatives and the brain
    Adám Vas
    Chemical Works of Gedeon Richter Ltd, Budapest, Hungary
    Med Res Rev 25:737-57. 2005
  4. ncbi Expression of messenger ribonucleic acid encoding for phosphodiesterase isoenzymes in human female genital tissues
    Stefan Uckert
    Hannover Medical School Department of Urology, Hannover, Germany, and IPF Pharmaceuticals GmbH Urological Research Unit, Hannover, Germany
    J Sex Med 4:1604-9. 2007
  5. ncbi Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cells
    M Cecilia Ortiz-Capisano
    Department of Medicine, Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1469-76. 2009
  6. ncbi Interaction of a kinesin-like protein with calmodulin isoforms from Arabidopsis
    V S Reddy
    Department of Biology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Biol Chem 274:31727-33. 1999
  7. ncbi Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells
    Mikael Ahlstrom
    Department of Applied Chemistry and Microbiology, University of Helsinki, P O Box 66, Helsinki 00014, Finland
    Biochem Pharmacol 69:267-75. 2005
  8. ncbi Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity
    Karina Matthiesen
    Department of Molecular Neurobiology, H Lundbeck A S, Ottiliavej 9, 2500 Copenhagen Valby, Denmark
    Biochem J 423:401-9. 2009
  9. ncbi Dihydroartemisinin can inhibit calmodulin, calmodulin-dependent phosphodiesterase activity and stimulate cellular immune responses
    Shokoofe Noori
    Department of Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    Int Immunopharmacol 10:213-7. 2010
  10. ncbi Fosinopril prevents the pulmonary arterial remodeling in sinoaortic-denervated rats by regulating phosphodiesterase
    Xia Tao
    Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, China
    J Cardiovasc Pharmacol 51:24-31. 2008

Research Grants

  1. Familiar Intracranial Aneurysm Study II (FIA II)
    Joseph Broderick; Fiscal Year: 2009
  2. Familial Intracranial Aneurysm Study II (FIA II)
    JOSEPH PAUL BRODERICK; Fiscal Year: 2010
  3. Regulation, interaction, and inhibitor discovery of phosphodiesterases
    Hengming Ke; Fiscal Year: 2010
  4. Novel PDE Inhibitors for Depression
    LAWRENCE WENNOGLE; Fiscal Year: 2007
  5. CONTROL OF CELL DIVISION BY CYCLIC AMP
    JAMES MALLER; Fiscal Year: 1980
  6. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
  7. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED FATEMI; Fiscal Year: 2009
  8. GABAergic Dysfunction in Autism
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
  9. CNS transcription modulation in peripheral inflammation
    Ma Li Wong; Fiscal Year: 2002
  10. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications82

  1. ncbi Variants in PDE11A and PDE1A are not associated with citalopram response
    K S Teranishi
    Mol Psychiatry 12:1061-3. 2007
  2. ncbi Differential effects of tamoxifen-like compounds on osteoclastic bone degradation, H(+)-ATPase activity, calmodulin-dependent cyclic nucleotide phosphodiesterase activity, and calmodulin binding
    J P Williams
    Department of Pathology, University of Alabama at Birmingham 35294, USA
    J Cell Biochem 66:358-69. 1997
    ..However, calmodulin antagonist activity varies between specific reactions, and free calcium regulates specificity of some interactions. Effects on whole cells probably also reflect other properties, including transport into cells...
  3. ncbi Eburnamine derivatives and the brain
    Adám Vas
    Chemical Works of Gedeon Richter Ltd, Budapest, Hungary
    Med Res Rev 25:737-57. 2005
    ..as a neuroprotective agent many non clinical and clinical studies proved vinpocetine's effects on calmodulin dependent phosphodiesterase E1, on sodium, calcium channels, peripheral benzodiazepine receptor, and glutamate receptors as ..
  4. ncbi Expression of messenger ribonucleic acid encoding for phosphodiesterase isoenzymes in human female genital tissues
    Stefan Uckert
    Hannover Medical School Department of Urology, Hannover, Germany, and IPF Pharmaceuticals GmbH Urological Research Unit, Hannover, Germany
    J Sex Med 4:1604-9. 2007
    ..The elevated expression of PDE5 in the human penile erectile tissue is considered the reason for the high clinical efficacy of PDE5 inhibitors in the pharmacotherapy of male erectile dysfunction...
  5. ncbi Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cells
    M Cecilia Ortiz-Capisano
    Department of Medicine, Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1469-76. 2009
    ..To determine which PDE1 isoform is involved, we performed Western blot analysis for PDE1A, B, and C. Only Western blot analysis for PDE1C showed a characteristic band apparent at 80 kDa...
  6. ncbi Interaction of a kinesin-like protein with calmodulin isoforms from Arabidopsis
    V S Reddy
    Department of Biology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Biol Chem 274:31727-33. 1999
    ..However, the affinity of calmodulin-4 and -6 isoforms for the motor was about the same. Based on these studies, we conclude that all calmodulin isoforms bind to the motor protein but with different affinities...
  7. ncbi Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells
    Mikael Ahlstrom
    Department of Applied Chemistry and Microbiology, University of Helsinki, P O Box 66, Helsinki 00014, Finland
    Biochem Pharmacol 69:267-75. 2005
    ..Expression of the following cAMP-PDE subtypes were detected by reverse transcriptase PCR (RT-PCR): PDE1A, PDE1C, PDE2A, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE10A and PDE11A...
  8. ncbi Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity
    Karina Matthiesen
    Department of Molecular Neurobiology, H Lundbeck A S, Ottiliavej 9, 2500 Copenhagen Valby, Denmark
    Biochem J 423:401-9. 2009
    ..In contrast with other GAF domain-containing PDEs, and with what has previously been predicted, ligand binding to the GAF domains of PDE10A and PDE11A does not stimulate catalytic activity...
  9. ncbi Dihydroartemisinin can inhibit calmodulin, calmodulin-dependent phosphodiesterase activity and stimulate cellular immune responses
    Shokoofe Noori
    Department of Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    Int Immunopharmacol 10:213-7. 2010
    ..The data indicated that DHA could stimulate the delayed type hypersensitivity (DTH) against sheep blood cells in Balb/c mice and reduced the tumor growth in vivo against invasive ductal carcinoma in Balb/c mice...
  10. ncbi Fosinopril prevents the pulmonary arterial remodeling in sinoaortic-denervated rats by regulating phosphodiesterase
    Xia Tao
    Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, China
    J Cardiovasc Pharmacol 51:24-31. 2008
    ..To study the effects of fosinopril on sinoaortic denervation (SAD)-induced pulmonary vascular remodeling and on phosphodiesterases (PDE) 1 in rats...
  11. ncbi Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway
    E Brigino
    Department of Pediatrics, University of South Florida, St Petersburg 33701, USA
    Proc Natl Acad Sci U S A 94:3178-82. 1997
    ..These findings indicate that extracellular Nef may contribute to the immunopathogenesis of HIV infection by inducing IL-10...
  12. ncbi Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons
    C Yan
    Department of Pharmacology, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 92:9677-81. 1995
    ..The high affinity for cAMP of this Ca2+/calmodulin-dependent PDE and the fact that its mRNA is highly concentrated in olfactory sensory neurons suggest an important role for it in a Ca(2+)-regulated olfactory signal termination...
  13. ncbi 3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues
    K Loughney
    ICOS Corporation, Bothell, WA, USA
    Int J Impot Res 17:320-5. 2005
    ..No PDE11A protein was detected in blood vessels or cardiac myocytes. None of the four potential PDE11A proteins were detected in human skeletal muscle, testis, or penis...
  14. ncbi Calmodulin inhibitory activity of the malbrancheamides and various analogs
    Kenneth A Miller
    Department of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, CO 80523 1872, USA
    Bioorg Med Chem Lett 18:6479-81. 2008
    ..2.2]diazaoctane core oxidation state on the ability of these analogs to inhibit calmodulin dependent phosphodiesterase (PDE1) was studied, and a number of potent compounds were identified.
  15. ncbi Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy
    Clint L Miller
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Circ Res 105:956-64. 2009
    ..Ca(2+)/calmodulin (CaM)-activated cGMP-hydrolyzing PDE1 family may play a pivotal role in balancing intracellular Ca(2+)/CaM and cGMP signaling; however, its function in cardiomyocytes is unknown...
  16. ncbi Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase
    M Hayashi
    Department of Molecular and Cellular Pharmacology, Department of Medical Informatics, First Department of Surgery, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie, 514, Japan
    Biochem Biophys Res Commun 250:751-6. 1998
    ..cAMP hydrolytic activity was unaffected by cGMP and no cGMP PDE hydrolysis were detectable at concentrations up to 100 microM. These findings suggest that PDE8B is a new member of the PDE8 family...
  17. ncbi Cloning of dog heart PDE1A - a first detailed characterization at the molecular level in this species
    J C Clapham
    Department of Crystallography, Birkbeck College, Malet Street, WC1E 7HX, London, UK
    Gene 268:165-71. 2001
    ..dog heart cDNA as a probe suggested the presence of an additional form of PDE1, in heart only, separate from the PDE1A group which was present in both heart and skeletal muscle...
  18. ncbi Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) splice variants from bovine cardiac muscle
    Shankar B Das
    Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E5
    Gene 396:283-92. 2007
    ..Interestingly, compared to other mammalian species, bovine PDE1A, PDE-small and PDE-large show a deletion at the C-terminal end of the catalytic domain of the gene...
  19. ncbi Gene expression and protein localization of calmodulin-dependent phosphodiesterase during ontogenesis of chick retina
    Stefania Deplano
    Dipartimento di Biologia, Universita di Genova, Genova, Italy
    J Neurosci Res 86:1017-23. 2008
    ..b>PDE1A was highly expressed at the early stages and decreased as development proceeded...
  20. ncbi Contribution of the cyclic nucleotide phosphodiesterases PdeA and PdeB to adaptation of Myxococcus xanthus cells to osmotic or high-temperature stress
    Yoshio Kimura
    Department of Life Sciences, Faculty of Agriculture, Kagawa University, Miki cho, Kagawa, Japan 761 0795
    J Bacteriol 188:823-8. 2006
    ..These results suggest that PdeA and PdeB may be involved in osmotic adaptation during spore germination and temperature adaptation during vegetative growth through the regulation of cAMP levels...
  21. ncbi Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival
    David J Nagel
    Cardiovascular Research Institute, University of Rochester, New York, USA
    Circ Res 98:777-84. 2006
    ..Here, we demonstrate that PDE1A, a Ca2+-calmodulin-stimulated PDE preferentially hydrolyzing cGMP, is predominantly cytoplasmic in medial "..
  22. ncbi Expression of cAMP and cGMP-phosphodiesterase isoenzymes 3, 4, and 5 in the human clitoris: immunohistochemical and molecular biology study
    Matthias Oelke
    Department of Urology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Urology 67:1111-6. 2006
    ..We sought to elucidate the presence of the phosphodiesterase (PDE) isoenzymes 3, 4, and 5 in the human clitoris using immunohistochemical and molecular biology methods...
  23. ncbi Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina
    Rocco Santone
    Dipartimento di Biologia di Base e Applicata, Universita di L Aquila, Coppito, Italy
    J Neurosci Res 84:1020-6. 2006
    ..Two PDE1A antibodies (against N-terminal and C-terminal peptides) detected a band at 79 kDa never described before...
  24. ncbi Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1
    Fiona Murray
    Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Am J Physiol Lung Cell Mol Physiol 292:L294-303. 2007
    ..Real-time PCR and immunoblotting demonstrated that the expression of PDE1A, PDE1C, PDE3B, and PDE5A was enhanced in PASMC from both IPAH and SPH patients compared with control PASMC...
  25. ncbi Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy
    Ralph Theo Schermuly
    University of Giessen Lung Centre, Justus Liebig Universitat Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Circulation 115:2331-9. 2007
    ..The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation...
  26. ncbi Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes
    Fabrice Vandeput
    Cardiology Section, Veterans Affairs Salt Lake City Health Care System, 500 Foothill Boulevard, Salt Lake City, UT 84148, USA
    J Biol Chem 282:32749-57. 2007
    ....
  27. ncbi Differential 2-D protein gel electrophoresis analysis of Legionella pneumophila wild type and Tat secretion mutants
    Emmy De Buck
    Laboratory of Bacteriology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Int J Med Microbiol 298:449-61. 2008
    ..LvrE was shown to play a role in intracellular growth in differentiated U937 cells...
  28. ncbi Adenosine deaminase inhibition enhances the inotropic response mediated by A1 adenosine receptor in hyperthyroid guinea pig atrium
    Adam Kemeny Beke
    Department of Ophthalmology, University of Debrecen, PO Box 30, H 4012 Debrecen, Hungary
    Pharmacol Res 56:124-31. 2007
    ..Furthermore, in the case of EHNA, inhibition of PDE2 also appears to contribute to the enhanced A1 adenosine receptor signaling in the hyperthyroid guinea pig atrium...
  29. ncbi The Rv0805 gene from Mycobacterium tuberculosis encodes a 3',5'-cyclic nucleotide phosphodiesterase: biochemical and mutational analysis
    Avinash R Shenoy
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India
    Biochemistry 44:15695-704. 2005
    ....
  30. ncbi Desensitization of the soluble guanylyl cyclase/cGMP pathway by lipopolysaccharide in rat isolated pulmonary artery but not aorta
    M S H El-Awady
    Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    Br J Pharmacol 155:1164-73. 2008
    ..To investigate the function of soluble guanylyl cyclase (sGC)/3',5'-cyclic guanosine monophosphate (cGMP) pathway in lipopolysaccharide (LPS)-induced changes in vascular reactivity of rat isolated pulmonary artery and aorta...
  31. ncbi Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1
    Fernanda R Giachini
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Hypertension 57:655-63. 2011
    ..1 ± 0.3 vs 5.3 ± 0.1). No differences in sildenafil-induced relaxation were observed. PDE1A and PDE1C expressions in aorta and PDE1A expression in SMA were increased in Ang II rats...
  32. ncbi Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II
    Walid Mokni
    CNRS UMR 7213, Biophotonique et Pharmacologie, Faculte de Pharmacie, Universite de Strasbourg, Illkirch, France
    PLoS ONE 5:e14227. 2010
    ..broadly increased (+130% for PDE1; +76% for PDE2; +113% for PDE5) and associated with increased expressions for PDE1A, PDE1C and PDE5A. The cGMP-PDE1 activation by Ca(2+)/CaM was reduced. BNP expression was increased by 3...
  33. ncbi Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells
    Kye Im Jeon
    Aab Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, NY 14642, USA
    FEBS J 277:5026-39. 2010
    ..Ca(2+)/calmodulin-stimulated phosphodiesterase 1 (PDE1) isozymes, including PDE1A and PDE1C, play integral roles in regulating the proliferation of synthetic VSMCs...
  34. ncbi Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis
    Abdurazzag Abusnina
    CNRS UMR 7213 Laboratoire de Biophotonique et Pharmacologie, Universite de Strasbourg, Faculte de Pharmacie, 74 route du Rhin, Illkirch, France
    Cell Signal 23:152-60. 2011
    ..Our results showed that TQ specifically repressed PDE1A expression in the acute lymphoblastic leukemia Jurkat cell line...
  35. ncbi Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues
    Viktor Lakics
    Neuroscience Discovery Research, Neurodegeneration Drug Hunting Team, Eli Lilly and Company Limited, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom
    Neuropharmacology 59:367-74. 2010
    ..In this study, we have established the mRNA expression profile all PDE isoenzymes (PDE1A/B/C, 2A, 3A/B, 4A/B/C/D, 5A, 6A/B/C, 7A/B, 8A/B, 9A, 10A, 11A) in a human cDNA collection consisting of 10 brain ..
  36. ncbi Levels of phosphodiesterase 4A and 4B are altered by chronic treatment with psychotropic medications in rat frontal cortex
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, Minneapolis, Minnesota 55455, USA
    Synapse 64:550-5. 2010
    ..We also measured levels of nine PDE subtypes via qRT-PCR in FC and found significant upregulation of PDE1A and PDE8B following treatment with olanzapine, while treatment with lithium reduced expression of mRNA for PDE8B...
  37. ncbi Intrinsic sex-specific differences in microvascular endothelial cell phosphodiesterases
    JianJie Wang
    Dept of Biomedical Science, Missouri State Univ, Springfield, 65897, USA
    Am J Physiol Heart Circ Physiol 298:H1146-54. 2010
    ..The predominant isoform among PDE1-5, present in both XY and XX EC, was PDE4. Expression mRNA levels of PDE1A (male > female) and PDE3B (male < female) were sex dependent; PDE2A, PDE4D, and PDE5A were sex independent...
  38. ncbi Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 67:1110-3. 2010
    ..We sought to replicate these associations in a study of a serotonin-norepinephrine reuptake inhibitor...
  39. ncbi Expression, activity, and function of phosphodiesterases in the mature and immature ductus arteriosus
    Hanguan Liu
    Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA
    Pediatr Res 64:477-81. 2008
    ..With advancing gestation, mRNA expression of the smooth muscle PDE isoforms (PDE1A, 1B, 1C, 3A, 3B, 4D, and 5A) increased in the ductus as did their hydrolytic activities...
  40. ncbi PDEs1-5 activity and expression in tissues of cirrhotic rats reveal a role for aortic PDE3 in NO desensitization
    Rima Tahseldar-Roumieh
    Biophotonique et Pharmacologie, CNRS UMR 7213, Universite de Strasbourg, 74 route du Rhin, Illkirch, France
    Int J Exp Pathol 90:605-14. 2009
    ..kidney of rats with cirrhosis had increased activity of PDE1 and PDE4 but not PDE5, and increased expression of PDE1A. Unexpectedly and interestingly, there was no change in cirrhotic aorta PDE5, but an increase in PDE3 and PDE4 ..
  41. ncbi The PDE1A-PKCalpha signaling pathway is involved in the upregulation of alpha-smooth muscle actin by TGF-beta1 in adventitial fibroblasts
    Hai Yan Zhou
    Shanghai Key Laboratory of Vascular Biology, Ruijin Hospital, and Laboratory of Vascular Biology, Health Science Center, Shanghai JiaoTong University School of Medicine and Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, Shanghai, China
    J Vasc Res 47:9-15. 2010
    ..This study aimed to evaluate the role of cyclic nucleotide phosphodiesterase 1A (PDE1A) in the formation of adventitial myofibroblasts induced by transforming growth factor (TGF)-beta(1).
  42. ncbi Intracranial self-stimulation to the lateral hypothalamus, a memory improving treatment, results in hippocampal changes in gene expression
    G Huguet
    Universitat de Girona, Departament de Biologia, Facultat de Ciencies, Campus de Montilivi, 17071 Girona, Spain
    Neuroscience 162:359-74. 2009
    ..Most of the proteins encoded by these genes, such as calmodulin-dependent-phosphodiesterase 1 A (Pde1a), are part of signal transduction machineries or are related to anti-apoptosis, as heat shock 70 kDa protein 1A (..
  43. ncbi The refinement of the critical region for the 2q31.2q32.3 deletion syndrome indicates candidate genes for mental retardation and speech impairment
    Alessandro Cocchella
    Division of Medical Genetics, Galliera Hospital, Genova, Italy
    Am J Med Genet B Neuropsychiatr Genet 153:1342-6. 2010
    ..The critical region points to a few genes, namely NEUROD1, ZNF804A, PDE1A, and ITGA4, which are good candidates to explain the cognitive and behavioural phenotype, as well as the severe ..
  44. ncbi Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+
    Tasmina A Goraya
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK
    Cell Signal 20:359-74. 2008
    ....
  45. ncbi Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1
    Abdurazzag Abusnina
    CNRS UMR 7213 Laboratoire de Biophotonique et Pharmacologie, Universite de Strasbourg, Faculte de Pharmacie, Illkirch, France
    Mol Nutr Food Res 55:1677-89. 2011
    ..Therefore, this study investigated PDE1-5 participations in the anti-proliferative properties of curcumin in B16F10 murine melanoma cells...
  46. ncbi Inhibition of phosphodiesterase 1 augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs with acute pulmonary hypertension
    Oleg V Evgenov
    Dept of Anesthesia and Critical Care, Mass General Hospital, Boston, MA 02114, USA
    Am J Physiol Lung Cell Mol Physiol 290:L723-L729. 2006
    ..Using RT-PCR, we detected PDE1A, PDE1B, and PDE1C mRNAs in pulmonary arteries and veins isolated from healthy lambs...
  47. ncbi Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence
    M Guipponi
    Division of Medical Genetics, University of Geneva Medical School and Cantonal Hospital of Geneva, Switzerland
    Hum Genet 103:386-92. 1998
    ..Since functional disturbances in intraneuronal signal transmission via second messengers play an important role in the pathophysiology of affective disorders, PDE9A is a strong candidate for such a role by position and function...
  48. ncbi Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase
    K Loughney
    ICOS Corporation, Bothell, WA 98021, USA
    Gene 216:139-47. 1998
    ..A 5'-splice variant, PDE5A2, encodes an 833-amino-acid protein with eight unique amino acids at the amino terminus. PDE5A maps to chromosome 4q 25-27...
  49. ncbi Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1
    J Yu
    ICOS Corporation, Bothell, WA 98021, USA
    Cell Signal 9:519-29. 1997
    ..The HSPDE1B1 gene was mapped to human chromosome 12. A partial genomic sequence of HSPDE1B1 was isolated and shown to contain two splice junctions that are conserved in the rat PDE4 and the Drosophila dunce genes...
  50. ncbi Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase
    G J Rosman
    ICOS Corporation, Bothell, WA 98201, USA
    Gene 191:89-95. 1997
    ..The different amino termini probably arise from alternative exon splicing of the PDE2A mRNA...
  51. ncbi E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts
    X Fu
    Department of Pathology, University of California, San Diego, School of Medicine, La Jolla 92093, USA
    Mol Cell Biol 17:1503-12. 1997
    ..chain, natriuretic peptide receptor C, mitochondrial fumarase, and the 3',5'-cyclic nucleotide phosphodiesterase, PDE1A) and 5 encoded new proteins related to angiogenin, ion channels, villin, epidermal growth factor repeat proteins, ..
  52. ncbi Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase
    S Spence
    Division of Biochemistry and Molecular Biology, University of Glasgow, Scotland, U K
    Biochem J 321:157-63. 1997
    ..Reverse transcriptase-PCR analyses, using degenerate primers able to detect the PDE1A and PDE1B isoforms, successfully amplified a fragment of the predicted size from RNA preparations of both CHO ..
  53. ncbi Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells
    X Jiang
    Department of Pharmacology, University of Connecticut Health Center, Farmington 06030, USA
    Proc Natl Acad Sci U S A 93:11236-41. 1996
    ..This suggests that PDEs, particularly PDE1B1, because its expression is selective, may be useful targets for inducing the death of leukemic cells...
  54. ncbi The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner
    C Yan
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 271:25699-706. 1996
    ..In summary, these findings suggest that the PDE1C gene undergoes tissue-specific alternative splicing that generates structurally and functionally diverse gene products...
  55. ncbi Characterization of a periplasmic 3':5'-cyclic nucleotide phosphodiesterase gene, cpdP, from the marine symbiotic bacterium Vibrio fischeri
    P V Dunlap
    Biology Department, Woods Hole Oceanographic Institution, Massachusetts 02543
    J Bacteriol 175:4615-24. 1993
    ..The mutant exhibited no obvious sensitivity to high extracellular concentrations of cAMP (5 and 10 mM), suggesting that the enzyme does not play a role in defense against extracellular cAMP...
  56. ncbi Mechanism of nafazatrom-induced inhibition of rat uterus contractions in vitro
    B Cantabrana
    Departamento de Medicina, Facultad de Medicina, Oviedo, Spain
    Arch Int Pharmacodyn Ther 301:285-98. 1989
    ....
  57. ncbi Comparative effects of vinpocetine and 8-Br-cyclic GMP on the contraction and 45Ca-fluxes in the rabbit aorta
    P J Chiu
    Department of Pharmacology, Schering-Plough Corporation, Bloomfield, NJ 07003
    Am J Hypertens 1:262-8. 1988
    ..The results suggest that vinpocetine may effect vasodilatation through blockade of the slow channel and selective inhibition of CaM-PDE in the vascular smooth muscle...
  58. ncbi Dissimilar mechanisms of action of anticalmodulin drugs: quantitative analysis
    F Orosz
    Institute of Enzymology, Hungarian Academy of Sciences, Budapest
    Mol Pharmacol 38:910-6. 1990
    ..The approach used in this study makes it possible to screen for the calmodulin antagonist effect of other drugs as well...
  59. ncbi Characterization of the human calmodulin-like protein expressed in Escherichia coli
    J A Rhyner
    Laboratory for Biochemistry, Swiss Federal Institute of Technology, Zurich
    Biochemistry 31:12826-32. 1992
    ..The highly tissue-specifically-expressed CLP represents a novel human Ca(2+)-binding protein showing characteristics of a CaM isoform...
  60. ncbi Molecular cloning of DNA encoding a calmodulin-dependent phosphodiesterase enriched in striatum
    J W Polli
    Section on Immunology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852
    Proc Natl Acad Sci U S A 89:11079-83. 1992
    ..By using nucleic acid probes for PDE1B1, the mechanisms that control its highly selective gene expression can now be studied at the molecular level...
  61. ncbi A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase
    D R Repaske
    Division of Pediatric Endocrinology, University of North Carolina, Chapel Hill 27599
    J Biol Chem 267:18683-8. 1992
    ..Molecular cloning of these PDEs will provide valuable tools for investigating the roles of these isozymes in regulation of intracellular concentrations of the cyclic nucleotides...
  62. ncbi Isolation and characterization of PDE10A, a novel human 3', 5'-cyclic nucleotide phosphodiesterase
    K Loughney
    ICOS Corporation, Bothell, WA 98021, USA
    Gene 234:109-17. 1999
    ..It hydrolyzed both cAMP and cGMP. Inhibitors that are selective for other PDE families are poor inhibitors of PDE10A; however, PDE10A is inhibited by the non-specific PDE inhibitor, IBMX...
  63. ncbi A new peptide (1150Da) selectively activates the calcium-calmodulin sensitive isoform of cyclic nucleotide phosphodiesterase from human myometrium
    M J Leroy
    INSERM U 361, Maternite Baudelocque, Paris, France
    Biochem Biophys Res Commun 184:700-5. 1992
    ..recently purified in rat and calf myometrium, is able to stimulate up to 55-fold, the calcium-calmodulin dependent phosphodiesterase isoform...
  64. ncbi Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm
    Valeria Vasta
    Department of Pharmacology, University of Washington, Seattle, 98195, USA
    Biol Reprod 73:598-609. 2005
    ..We have cloned from mouse testis a novel calmodulin-stimulated cyclic nucleotide phosphodiesterase 1A isoform, Pde1a_v7 (mmPDE1A7), which arises from an alternative transcription start in the cyclic nucleotide ..
  65. ncbi Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracellular second messenger systems
    F Martel
    Department of Biochemistry, Faculty of Medicine, Porto, Portugal
    Naunyn Schmiedebergs Arch Pharmacol 364:487-95. 2001
    ..showed an increase in the presence of exogenous alkaline phosphatase. In conclusion, these results suggest that hEMT is regulated by phosphorylation/dephosphorylation mechanisms, being active in the dephosphorylated state...
  66. ncbi Analysis of the autism chromosome 2 linkage region: GAD1 and other candidate genes
    Raquel Rabionet
    Department of Medicine, Center for Human Genetics, 595 LaSalle St, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 372:209-14. 2004
    ..whose levels are reduced in autopsy brain material from autistic subjects, and STK17B, ABI2, CTLA4, CD28, NEUROD1, PDE1A, HOXD1 and DLX2...
  67. ncbi Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A
    Tasmina A Goraya
    Department of Pharmacology, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1PD, United Kingdom
    J Biol Chem 279:40494-504. 2004
    ..In 1321N1 human astrocytoma cells, the endogenous PDE1 (identified as PDE1A by reverse transcriptase-PCR) was largely insensitive to Ca2+ released from carbachol-sensitive stores but was ..
  68. ncbi Positive inotropic effect of the inhibition of cyclic GMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase (PDE2) on guinea pig left atria in eu- and hyperthyroidism
    R Gesztelyi
    Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary
    Gen Physiol Biophys 22:501-13. 2003
    ....
  69. ncbi [The radiation-modifying capacity of xenogenic apotransferrin for the number of endogenous colony forming units in the spleen of irradiated mice]
    A N Koterov
    State Research Center Institute of Biophysics, Ministry of Public Health of Russian Federation, Moscow, 123182 Russia
    Radiats Biol Radioecol 43:647-53. 2003
    ....
  70. ncbi cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles
    Noriyuki Yanaka
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, Yodogawa ku, Osaka 532 8505, Japan
    Biosci Biotechnol Biochem 67:973-9. 2003
    ..The absence of significant changes in PDE1A and PDE2A mRNA levels indicated that the two PDE activities were post-transcriptionally up-regulated...
  71. ncbi Implication of calmodulin-dependent phosphodiesterase type 1 during bovine sperm capacitation
    Valerie Fournier
    Departement des Sciences Animales, Universite Laval, Quebec, Quebec Canada
    J Androl 24:104-12. 2003
    ..Although cAMP regulation by PDE 1 may occur early during capacitation, downstream events appear to prevent full capacitation from occurring prematurely...
  72. ncbi Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa
    Linda Lefievre
    Urology Research Laboratory, Royal Victoria Hospital and Faculty of Medicine, McGill University, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Biol Reprod 67:423-30. 2002
    ..Immunocytochemical data indicated that PDE1A, a variant of PDE1, is localized on the equatorial segment of the sperm head as well as on the mid and principal ..
  73. ncbi Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I
    Mirko Ritter
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, D 93042 Regensburg, Germany
    Genomics 79:693-702. 2002
    ..several encoded known proteins, including serum amyloid A(2a) (SAA(2a)), apoC-I, and phosphodiesterase HCAM1 (PDE1A), found to interact with apoA-I...
  74. ncbi Differential changes in the expression of cyclic nucleotide phosphodiesterase isoforms in rat brains by chronic treatment with electroconvulsive shock
    C H Cho
    Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Korea
    Exp Mol Med 32:110-4. 2000
    ..In the hippocampus, the expression of PDE1A/B (694%), PDE4A (158%), PDE4B (323 %), and PDE4D (181%) isoforms was increased from the controls, but the ..
  75. ncbi The effects of phosphodiesterase inhibition on cyclic GMP and cyclic AMP accumulation in the hippocampus of the rat
    - van Staveren WC
    Maastricht University, Department of Psychiatry and Neuropsychology, Universiteitssingel 50, POB 616, 6200 MD, Maastricht, The Netherlands
    Brain Res 888:275-286. 2001
    ..The results suggest an interaction between cGMP and cAMP signalling pathways in astrocytes of the rat hippocampus...
  76. ncbi Hormone-specific combinations of isoforms of adenylyl cyclase and phosphodiesterase in the rat liver
    K Yamatani
    The Third Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iidanishi, 990 9585, Yamagata, Japan
    Regul Pept 99:45-52. 2001
    ....
  77. ncbi Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization
    H Michibata
    Discovery Research Laboratory, Tanabe Seiyaku Co Ltd, 2 50 Kawagishi 2 chome, Toda, Saitama 335 8505, Japan
    Biochim Biophys Acta 1517:278-87. 2001
    We report here the identification of novel human PDE1A splice variants, their tissue distribution patterns, genomic structure, and chromosomal localization of the gene...
  78. ncbi Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis
    C Yan
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    Biol Reprod 64:1746-54. 2001
    ..We examined the spatial and temporal expression profiles of three knownCaM-PDE genes, PDE1A, PDE1B, and PDE1C, in the testis...
  79. ncbi Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants
    Mark Fidock
    Discovery Biology, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
    Cell Signal 14:53-60. 2002
    ..We isolated cDNAs representing multiple splice variants of PDE1A, 1B and 1C from a variety of tissues. Included among these were two novel splice variants for PDE1A and 1B...
  80. ncbi Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample
    Michael Cabanero
    Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 3719, USA
    Pharmacogenet Genomics 19:235-8. 2009
    ..We genotyped three single nucleotide polymorphisms (SNPs) in PDE11A (rs1880916), PDE1A (rs1549870), and PDE9A (rs729861) for replication and we also report three additional SNPs in PDE11A (rs3770016, ..
  81. ncbi Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases
    K Loughney
    ICOS Corporation, Bothell, Washington 98021, USA
    J Biol Chem 271:796-806. 1996
    ..One, Hcam1 (PDE1A3), corresponds to the bovine 61-kDa CaM PDE (PDE1A2)...
  82. ncbi Isolation, expression and analysis of splice variants of a human Ca2+/calmodulin-stimulated phosphodiesterase (PDE1A)
    P B Snyder
    ICOS Corporation, Bothell, WA 98021, USA
    Cell Signal 11:535-44. 1999
    The PDE1A gene encodes a Ca2+/calmodulin-stimulated 3',5'-cyclic nucleotide phosphodiesterase (PDE)...

Research Grants37

  1. Familiar Intracranial Aneurysm Study II (FIA II)
    Joseph Broderick; Fiscal Year: 2009
    ..a final GWAS dataset of 407 FIA cases and 396 controls, we identified COL9A1 (collagen 9A1 gene) and PDE1A (phosphodiesterase 1A gene) as high priority candidate genes based not only the strength of the association with FIA but also on ..
  2. Familial Intracranial Aneurysm Study II (FIA II)
    JOSEPH PAUL BRODERICK; Fiscal Year: 2010
    ..a final GWAS dataset of 407 FIA cases and 396 controls, we identified COL9A1 (collagen 9A1 gene) and PDE1A (phosphodiesterase 1A gene) as high priority candidate genes based not only the strength of the association with FIA but also on ..
  3. Regulation, interaction, and inhibitor discovery of phosphodiesterases
    Hengming Ke; Fiscal Year: 2010
    ..of PDE8A and its complexes with inhibitors and with the binding protein I?B, (3) structural and kinetic studies on PDE1A in complex with calmodulin, and (4) structure-based discovery of PDE4 inhibitors for treatment of inflammatory ..
  4. Novel PDE Inhibitors for Depression
    LAWRENCE WENNOGLE; Fiscal Year: 2007
    ..We have developed a detailed plan to assess potential toxicities associated with PDE-1B inhibitors. ..
  5. CONTROL OF CELL DIVISION BY CYCLIC AMP
    JAMES MALLER; Fiscal Year: 1980
    ..Such altered phosphoproteins may be candidates for regulatory molecules that maintain the physiological arrest of the oocyte on prophase...
  6. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  7. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  8. GABAergic Dysfunction in Autism
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  9. CNS transcription modulation in peripheral inflammation
    Ma Li Wong; Fiscal Year: 2002
    ..The proposed studies will result in new data that will be needed for us to generate novel testable hypotheses, which will provide the framework for future R0l applications. ..
  10. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  11. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  12. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  13. Depression/Metabolic Syndrome in Mexican-American Women.
    Ma Li Wong; Fiscal Year: 2006
    ..This work will address this important area by the study of an population group who is markedly under represented in patient-oriented investigation. ..
  14. Prenatal Virally Induced Brain Disorder in Mouse
    S Fatemi; Fiscal Year: 2007
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  15. Pharmacogenetics of Antidepressant Drugs
    Ma Li Wong; Fiscal Year: 2007
    ..This K-24 award will make possible for the P.I. to significantly increase her time allocation for patient-oriented research and for mentoring of junior trainees and fellows in clinical research. ..
  16. GABAergic and Reelin Deficits in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..subjects with bipolar disorder, major depression, and matched controls. Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development. ..