p70S6K

Summary

Gene Symbol: p70S6K
Description: ribosomal protein S6 kinase, 70kDa, polypeptide 1
Alias: PS6K, S6K, S6K1, STK14A, p70(S6K)-alpha, p70-S6K, p70-alpha, 70 kDa ribosomal protein S6 kinase 1, P70S6K1, S6K-beta-1, p70 S6 kinase, alpha 1, p70 S6 kinase, alpha 2, p70 S6K-alpha, p70 S6KA, ribosomal protein S6 kinase I, ribosomal protein S6 kinase beta-1, serine/threonine kinase 14 alpha, serine/threonine-protein kinase 14A
Species: human

Top Publications

  1. ncbi Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes
    P T Pham
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Biochem 79:427-41. 2000
  2. ncbi Treatment with TNF-alpha and IFN-gamma alters the activation of SER/THR protein kinases and the metabolic response to IGF-I in mouse c2c12 myogenic cells
    Katarzyna Grzelkowska-Kowalczyk
    Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences SGGW, Nowoursynowska 159, 02 776, Warsaw, Poland
    Cell Mol Biol Lett 15:13-31. 2010
  3. ncbi G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells
    Ning Gao
    1820 MBR Cancer Center and Dept of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Am J Physiol Cell Physiol 287:C281-91. 2004
  4. ncbi Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini
    J R Grove
    Medical Services, Massachusetts General Hospital, Boston
    Mol Cell Biol 11:5541-50. 1991
  5. ncbi Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation
    Tomoko Sunami
    Department of Chemistry, Tsukuba Research Institute, Banyu Pharmaceutical Company, Limited, Tsukuba, Ibaraki, 300 2611, Japan
    J Biol Chem 285:4587-94. 2010
  6. ncbi Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
    Masao Saitoh
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Biol Chem 277:20104-12. 2002
  7. ncbi Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase
    Xiuwen Tang
    Division of Cell Signalling, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 374:137-43. 2003
  8. ncbi The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    Laura S Harrington
    Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Rd, London SW3 6JB, England, UK
    J Cell Biol 166:213-23. 2004
  9. ncbi IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells
    Kiyotaka Kawauchi
    Department of Medicine, Daini Hospital, Tokyo Women s Medical University, Arakawa ku, Tokyo, Japan
    J Immunol 174:5261-9. 2005
  10. ncbi Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
    S Isotani
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 274:34493-8. 1999

Research Grants

  1. Amino Acids and Muscle Protein Synthesis
    Robert Wolfe; Fiscal Year: 2006
  2. Mechanism of thrombin-induced tolerance to brain injury
    Guohua Xi; Fiscal Year: 2010
  3. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2005
  4. Mechanisms of S6K1 Mediated Insulin Resistance
    George Thomas; Fiscal Year: 2007
  5. Mechanisms of S6K1 Mediated Insulin Resistance
    George Thomas; Fiscal Year: 2010
  6. Alcohol Consumption and Risk of NHL: Role of MTOR Dysfunction
    RONALD BENJAMIN GARTENHAUS; Fiscal Year: 2010
  7. Alcohol Consumption and Risk of NHL: Role of MTOR Dysfunction
    Ronald Gartenhaus; Fiscal Year: 2009
  8. Mitotic Regulation of Ribosomal S6 Protein Kinases
    Omar Shah; Fiscal Year: 2004
  9. Pharmacodynamic-guided Dose-finding Study of Rapamycin
    Manuel Hidalgo; Fiscal Year: 2005
  10. Autophagy and protein translation in neural function & neurodegeneration
    Albert R La Spada; Fiscal Year: 2010

Detail Information

Publications155 found, 100 shown here

  1. ncbi Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes
    P T Pham
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Biochem 79:427-41. 2000
    Enhanced phosphorylation of the ribosomal protein s6 kinase, p70(s6k), and the translational repressor, 4E-BP1, are associated with either insulin-induced or amino acid-induced protein synthesis...
  2. ncbi Treatment with TNF-alpha and IFN-gamma alters the activation of SER/THR protein kinases and the metabolic response to IGF-I in mouse c2c12 myogenic cells
    Katarzyna Grzelkowska-Kowalczyk
    Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences SGGW, Nowoursynowska 159, 02 776, Warsaw, Poland
    Cell Mol Biol Lett 15:13-31. 2010
    ..was to compare the effects of TNF-alpha, IL-1beta and IFN-gamma on the activation of protein kinase B (PKB), p70(S6k), mitogen-activated protein kinase (MAPK) and p90( rsk ), and on IGF-I-stimulated glucose uptake and protein ..
  3. ncbi G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells
    Ning Gao
    1820 MBR Cancer Center and Dept of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Am J Physiol Cell Physiol 287:C281-91. 2004
    ..The inhibition of PI3K activity also inhibited the phosphorylation of AKT and p70S6K1, but not extracellular regulated kinase 1/2...
  4. ncbi Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini
    J R Grove
    Medical Services, Massachusetts General Hospital, Boston
    Mol Cell Biol 11:5541-50. 1991
    ..Transient expression of p70 alpha I and alpha II S6 kinase cDNA in COS cells results in a 2.5- to 4-fold increase in overall S6 kinase activity...
  5. ncbi Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation
    Tomoko Sunami
    Department of Chemistry, Tsukuba Research Institute, Banyu Pharmaceutical Company, Limited, Tsukuba, Ibaraki, 300 2611, Japan
    J Biol Chem 285:4587-94. 2010
    ..We report the crystal structures of the kinase domain of p70S6K1 bound to staurosporine in both the unphosphorylated state and in the 3'-phosphoinositide-dependent kinase-1-..
  6. ncbi Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
    Masao Saitoh
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Biol Chem 277:20104-12. 2002
    A critical step in S6 kinase 1 (S6K1) activation is Thr(229) phosphorylation in the activation loop by the phosphoinositide-dependent protein kinase (PDK1)...
  7. ncbi Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase
    Xiuwen Tang
    Division of Cell Signalling, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 374:137-43. 2003
    ..cholinergic receptors, coupled to phospholipase C, evoked a persistent 10-20-fold activation of p70 S6 kinase (S6K1)...
  8. ncbi The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    Laura S Harrington
    Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Rd, London SW3 6JB, England, UK
    J Cell Biol 166:213-23. 2004
    ..The tuberous sclerosis complex (TSC1-2) suppresses cell growth by negatively regulating a protein kinase, p70S6K (S6K1), which generally requires PI3K signals for its activation...
  9. ncbi IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells
    Kiyotaka Kawauchi
    Department of Medicine, Daini Hospital, Tokyo Women s Medical University, Arakawa ku, Tokyo, Japan
    J Immunol 174:5261-9. 2005
    ..hTERT was coimmunoprecipitated with Akt, Hsp90, mTOR, and p70 S6 kinase (S6K), suggesting that these molecules form a physical complex...
  10. ncbi Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
    S Isotani
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 274:34493-8. 1999
    ....
  11. ncbi Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells
    Xiao Feng Le
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Mol Cancer Ther 6:2843-57. 2007
    ..LY294002), c-jun NH(2)-terminal kinase (SP600125), and mammalian target of rapamycin (mTOR)/p70 S6 kinase (p70S6K; rapamycin) increased cyclin G2 expression...
  12. ncbi Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer
    F J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer Res 59:1408-11. 1999
    ..As part of an examination of expressed sequence tags for novel amplified genes in this region, we identified PS6K amplifications in both breast tumor tissues and cell lines...
  13. ncbi Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling
    Kathleen A Martin
    Division of Vascular Surgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Biol Chem 282:36112-20. 2007
    ..reported that rapamycin promotes VSMC differentiation by inhibiting the mammalian target of rapamycin (mTOR) target S6K1. Here, we show that rapamycin activates Akt and induces contractile protein expression in human VSMC in an insulin-..
  14. ncbi mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    Marina K Holz
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 123:569-80. 2005
    In response to nutrients, energy sufficiency, hormones, and mitogenic agents, S6K1 phosphorylates several targets linked to translation...
  15. ncbi Dual requirement for a newly identified phosphorylation site in p70s6k
    B A Moser
    Department of Growth Control, Friedrich Miescher Institut, Basel, Switzerland
    Mol Cell Biol 17:5648-55. 1997
    The activation of p70s6k is associated with multiple phosphorylations at two sets of sites...
  16. ncbi 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
    D R Alessi
    Department of Biochemistry, MRC Phosphorylation Unit, University of Dundee, Dundee, UK
    Curr Biol 8:69-81. 1998
    ..It is not known which protein kinases phosphorylate and activate p70...
  17. ncbi Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway
    Ding Yu Lee
    Division of Medical Engineering Research, National Health Research Institutes, Miaoli 350, Taiwan
    J Biol Chem 285:30-42. 2010
    ..5 +/- 4 dynes/cm(2)) to MG63 cells induced sustained activation of phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR/p70S6K (p70S6 kinase) signaling cascades and hence cell proliferation, which was accompanied by increased expression of ..
  18. ncbi RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
    P E Burnett
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:1432-7. 1998
    ..Here, we show that RAFT1 directly phosphorylates p70(S6k), 4E-BP1, and 4E-BP2 and that serum stimulates RAFT1 kinase activity with kinetics similar to those of p70(S6k) and ..
  19. ncbi Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region
    I Gout
    Ludwig Institute for Cancer Research, London W1P 8BY and the Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, United Kingdom
    J Biol Chem 273:30061-4. 1998
    ..The p70beta kinase was found to be significantly less sensitive to wortmannin and rapamycin than p70alpha. These results indicate that p70beta has the potential to participate in the regulation of protein synthesis and the cell cycle...
  20. ncbi Phosphorylation and activation of p70s6k by PDK1
    N Pullen
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Science 279:707-10. 1998
    Activation of the protein p70s6k by mitogens leads to increased translation of a family of messenger RNAs that encode essential components of the protein synthetic apparatus...
  21. ncbi Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C zeta-dependent manner
    A M Valverde
    , Centro Mixto CSIC/UCM, Facultad de Farmacia, Universidad Complutense, 28040, Madrid, Spain
    FEBS Lett 472:153-8. 2000
    ..However, activation of Akt/PKB or p70 S6 kinase (p70(s6k)) by insulin remained unaltered...
  22. ncbi Changes of insulin-mediated protein kinases phosphorylation and the expression of IGFBP-3 in skeletal muscle of streptozotocin-diabetic mice
    K Grzelkowska-Kowalczyk
    Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Nowoursynowska 159, 02 776 Warsaw, Poland
    Pol J Vet Sci 8:231-40. 2005
    ..the basal and insulin-mediated phosphorylation of protein kinase B (PKB), protein kinase Czeta (PKCzeta), p70(S6k), mitogen-activated protein kinase (MAPK)/p90(rsk) pathway and the expression of IGFBP-3, -4, and -5 in mice ..
  23. ncbi Mechanism of PDK1-catalyzed Thr-229 phosphorylation of the S6K1 protein kinase
    Malik M Keshwani
    Department of Chemistry, University of Miami, Coral Gables, Florida 33124, USA
    J Biol Chem 284:22611-24. 2009
    PDK1 (phosphoinositide-dependent protein kinase-1) catalyzes phosphorylation of Thr-229 in the T-loop of S6K1 alpha II (the 70-kDa 40 S ribosomal protein S6 kinase-1 alpha II isoform), and Thr-229 phosphorylation is synergistic with C-..
  24. ncbi Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain
    C Martín De La Vega
    Departamento de Investigacion, Hospital Ramon y Cajal, Ctra Colmenar Km 9, 28034 Madrid, Spain
    Biochem J 357:819-26. 2001
    ..4E-BP1) phosphorylation levels, eIF4F complex formation, as well as eIF2B and ribosomal protein S6 kinase (p70(S6K)) activities, were determined in different subcellular fractions from the cortex and the hippocampus [the CA1-..
  25. ncbi Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1
    Ayaz Najafov
    University of Dundee, Scotland, UK
    Biochem J 433:357-69. 2011
    ..or MEF (mouse embryonic fibroblast) cells ablated T-loop residue phosphorylation and activation of SGK isoforms and S6K1 induced by serum or IGF1 (insulin-like growth factor 1)...
  26. ncbi Methionine deprivation regulates the S6K1 pathway and protein synthesis in avian QM7 myoblasts without activating the GCN2/eIF2 alpha cascade
    Sonia Métayer-Coustard
    INRA, UR83 Recherches Avicoles, Nouzilly, France
    J Nutr 140:1539-45. 2010
    Amino acids modulate mRNA translation through the 70 kDa ribosomal protein S6 kinase (S6K1) and the general control nondepressible 2 protein kinase (GCN2)/eukaryotic initiation factor 2 alpha eIF2 alpha pathways...
  27. ncbi S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
    Mario Pende
    Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland
    Mol Cell Biol 24:3112-24. 2004
    ..In mammals, two genes encoding homologous S6Ks, S6K1 and S6K2, have been identified...
  28. ncbi A potential role for extracellular signal-regulated kinases in prostaglandin F2alpha-induced protein synthesis in smooth muscle cells
    G N Rao
    Division of Cardiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 274:12925-32. 1999
    ..and phosphatidylinositol 3-kinase (PI3-kinase) and their downstream targets ribosomal protein S6 kinase (p70(S6k)) and eukaryotic initiation factor eIF4E and its regulator 4E-BP1...
  29. ncbi Branched chain amino acids activate messenger ribonucleic acid translation regulatory proteins in human skeletal muscle, and glucocorticoids blunt this action
    Z Liu
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 86:2136-43. 2001
    ..of eukaryotic initiation factor 4E-binding protein 1 (eIF4E-BP1) and ribosomal protein S6 kinase (p70(S6K)) in skeletal muscle of seven healthy volunteers...
  30. ncbi mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
    Juan M García-Martínez
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 416:375-85. 2008
    ..established that mTORC1 [mTOR (mammalian target of rapamycin) complex 1] phosphorylates the hydrophobic motif of S6K (S6 kinase), whereas mTORC2 (mTOR complex 2) phosphorylates the hydrophobic motif of Akt (also known as protein ..
  31. ncbi Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
    Juan M García-Martínez
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD15EH, Scotland, UK
    Biochem J 421:29-42. 2009
    ..of AGC (protein kinase A/protein kinase G/protein kinase C) family kinases such as Akt (protein kinase B), S6K (p70 ribosomal S6 kinase) and SGK (serum and glucocorticoid protein kinase)...
  32. ncbi Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue
    Christopher J Lynch
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 283:E503-13. 2002
    ..This results in phosphorylation of the ribosomal protein S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E-binding protein-1 (4E-BP1), two proteins involved in the initiation phase of ..
  33. ncbi Luteinizing hormone stimulates mammalian target of rapamycin signaling in bovine luteal cells via pathways independent of AKT and mitogen-activated protein kinase: modulation of glycogen synthase kinase 3 and AMP-activated protein kinase
    Xiaoying Hou
    Professor and Director of Research and Development, 983255 Nebraska Medical Center, Omaha, Nebraska 68198 3255, USA
    Endocrinology 151:2846-57. 2010
    ..activation of the LH receptor stimulates the phosphorylation of the MTOR substrates ribosomal protein S6 kinase 1 (S6K1) and eukaryotic translation initiation factor 4E binding protein 1...
  34. ncbi An intracellular calcium signal activates p70 but not p90 ribosomal S6 kinase in liver epithelial cells
    L M Graves
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 272:1920-8. 1997
    ..kinase C activity (the phorbol ester 12-O-tetradecanoylphorbol-13-acetate) to activate p70 ribosomal S6 kinase (p70(S6K)) and p90 ribosomal S6 kinase (p90(RSK))...
  35. ncbi AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2alpha
    Edward W Arvisais
    Olson Center for Women s Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska 68198 3255, USA
    J Biol Chem 281:26904-13. 2006
    ..to determine whether PGF2alpha stimulates the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase 1 (S6K1) signaling pathway in steroidogenic luteal cells...
  36. ncbi Tissue-specific regulation of 4E-BP1 and S6K1 phosphorylation by alpha-ketoisocaproate
    Fumiaki Yoshizawa
    Department of Animal Science, Utsunomiya University, 350 Mine machi, Utsunomiya, Tochigi 321 8505, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:56-60. 2004
    ..repressor, eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (S6K1)...
  37. ncbi The S6 kinase signaling pathway in the control of development and growth
    George Thomas
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Biol Res 35:305-13. 2002
    ..immunosuppressant rapamycin, a bacterial macrolide, in conjunction with dominant interfering and activated forms of S6K1 has helped to establish the role of this signaling cascade in the regulation of growth and proliferation (Dennis ..
  38. ncbi Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway
    Francisco Altamirano
    Facultad de Medicina, Instituto de Ciencias Biomedicas, Centro FONDAP Estudios Moleculares de la Celula, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile
    J Endocrinol 202:299-307. 2009
    ..Testosterone increases the phosphorylation of mTOR and its downstream targets 40S ribosomal protein S6 kinase 1 (S6K1; also known as RPS6KB1) and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1)...
  39. ncbi Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis
    Marco Tampellini
    Division of Medical Oncology, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Regione Gonzole 10, 10043, Orbassano, Turin, Italy
    Virchows Arch 450:321-8. 2007
    ..in colorectal carcinoma (CRC) cells regulates cell adhesion and invasiveness via ribosomal protein S6 kinase (S6K) phosphorylation in pre-clinical studies...
  40. ncbi Glucocorticoids differentially modulate insulin-mediated protein and glycogen synthetic signaling downstream of protein kinase B in rat myocardium
    Yangsong Wu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Endocrinology 145:1161-6. 2004
    ..phosphorylation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (p70(S6K)) (P < 0.003 for both). Insulin enhanced the phosphorylation of Akt (P < 0.04), 4E-BP1 (P < 0...
  41. ncbi Developmental decline in components of signal transduction pathways regulating protein synthesis in pig muscle
    Scot R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 282:E585-92. 2002
    ..of the eukaryotic initiation factor (eIF)4E-binding protein (4E-BP1) and the ribosomal protein S6 kinase (S6K1). These effects of feeding are substantially reduced with development...
  42. ncbi Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    Andrew R Tee
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:13571-6. 2002
    ..signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1)...
  43. ncbi Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth
    Amelia Smyk
    Institute of Biochemistry, Warsaw University, Warsaw, Poland
    FEBS J 273:4728-41. 2006
    ..The screen yielded polymerase delta interacting protein 46 or S6K1 Aly/REF-like target (PDIP46/SKAR), a protein possessing one RNA recognition motif (RRM) and being a protein partner ..
  44. ncbi Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism
    Charles H Lang
    Pennsylvania State College of Medicine, Department of Cellular and Molecular Physiology H166, Hershey, PA 17033, USA
    Alcohol Clin Exp Res 28:1758-67. 2004
    ..the ability of alcohol to suppress insulin-like growth factor (IGF)-I stimulation of ribosomal S6 kinase 1 (S6K1) and 4E-BP1 phosphorylation, which are central elements in the signal transduction pathway used to coordinate the ..
  45. ncbi Expression, purification, and characterization of a structurally disordered and functional C-terminal autoinhibitory domain (AID) of the 70 kDa 40S ribosomal protein S6 kinase-1 (S6K1)
    Timothy J Ragan
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, P O Box 016129, Miami, FL 33101 6129, USA
    Protein Expr Purif 57:271-9. 2008
    b>S6K1 is a member of the AGC subfamily of serine-threonine protein kinases, whereby catalytic activation requires dual phosphorylation of critical residues in the conserved T-loop (T229) and hydrophobic motif (HM; T389) peptide regions of ..
  46. ncbi Immunohistochemical analysis of Ki-67, PCNA and S6K1/2 expression in human breast cancer
    Valeriy Lyzogubov
    R E Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS of Ukraine, Kyiv, Ukraine
    Exp Oncol 27:141-4. 2005
    To assess the correlation between the expression profiles of ribosomal protein S6 kinase (S6K1/2), Ki-67 nuclear antigen (Ki-67) and proliferating cell nuclear antigen (PCNA) in human breast adenocarcinomas.
  47. ncbi Arabidopsis S6 kinase mutants display chromosome instability and altered RBR1-E2F pathway activity
    Rossana Henriques
    Royal Holloway, University of London, School of Biological Sciences, Egham Hill, Egham, UK
    EMBO J 29:2979-93. 2010
    ..single- and double-knockout mutations and RNA-interference (RNAi)-silencing lines in the linked Arabidopsis S6K1 and S6K2 genes...
  48. ncbi Regulation of ribosomal protein S6 kinases by ubiquitination
    Mong Lien Wang
    Department of Structural and Molecular Biology, University College London, Gower Street, Darwin Building, London WC1E 6BT, United Kingdom
    Biochem Biophys Res Commun 369:382-7. 2008
    Ribosomal protein S6 kinase (S6K) is a key player in the regulation of cell growth and energy metabolism via the mTOR and PI3K signalling pathways...
  49. ncbi Contraction-mediated mTOR, p70S6k, and ERK1/2 phosphorylation in aged skeletal muscle
    Jascha D Parkington
    Department of Health Sciences, Boston University, Boston, MA 02215, USA
    J Appl Physiol 97:243-8. 2004
    ..TA) muscles were assayed for mammalian target of rapamycin (mTOR), 70-kDa ribosomal protein S6 kinase (p70(S6K)), and extracellular signal-regulated kinase (ERK) 1/2 phosphorylation and total protein either at baseline, ..
  50. ncbi Role of mTOR signaling in intestinal cell migration
    J Marc Rhoads
    Div of Gastroenterology, Dept of Pediatrics, Univ of Texas Medical School at Houston, 6431 Fannin St, MSB 7 137, Houston, TX 77030, USA
    Am J Physiol Gastrointest Liver Physiol 291:G510-7. 2006
    ..of the mammalian target of rapamycin (mTOR; FRAP), which is functionally linked to ribosomal protein s6 kinase (p70(s6k)), a kinase that plays a critical regulatory role in the translation of mRNAs and protein synthesis...
  51. ncbi mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF
    Katherine M Hannan
    Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, USA
    Mol Cell Biol 23:8862-77. 2003
    ..mTOR) is a key regulator of cell growth acting via two independent targets, ribosomal protein S6 kinase 1 (S6K1) and 4EBP1...
  52. ncbi Functions and regulation of the 70kDa ribosomal S6 kinases
    Tim R Fenton
    Ludwig Institute for Cancer Research, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0660, USA
    Int J Biochem Cell Biol 43:47-59. 2011
    The 70kDa ribosomal protein S6 kinases, S6K1 and S6K2 are two highly homologous serine/threonine kinases that are activated in response to growth factors, cytokines and nutrients...
  53. ncbi Phosphatidylinositol 3-kinase (PI-3K)/Akt but not PI-3K/p70 S6 kinase signaling mediates IGF-1-promoted lens epithelial cell survival
    Gudiseva Chandrasekher
    Department of Ophthalmology and Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 45:3577-88. 2004
    ..the ability of insulin-like growth factor (IGF)-1 to prevent apoptosis in lens epithelial cells and the involvement of phosphatidylinositol 3-kinase (PI-3K)/Akt and PI-3K/p70 S6 kinase (p70 S6K) signaling in the cell-survival process.
  54. ncbi Nitric oxide donors selectively potentiate thrombin-stimulated p70(S6k) activity and morphological changes in Swiss 3T3 cells
    L A Berven
    John Curtin School of Medical Research, Australian National University, Canberra City, ACT, 2601, Australia
    Biochem Biophys Res Commun 266:352-60. 1999
    ..We report here that nitric oxide (NO) donors selectively enhance thrombin-stimulated p70(S6k) activity by 40-60%, an effect that was sustained for 24 h...
  55. ncbi AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions
    David M Thomson
    Human Performance Laboratory, Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
    J Appl Physiol 104:625-32. 2008
    ..ACC), Akt, eukaryotic initiation factor 4E-binding protein (4E-BP1), 70-kDa ribosomal protein S6 kinase (S6K1), and eukaryotic elongation factor 2 (eEF2) phosphorylations were assessed by Western blot...
  56. ncbi Beta-adrenergic receptors (betaAR) regulate cardiomyocyte proliferation during early postnatal life
    Y T Tseng
    Department of Pediatrics, Rhode Island Hospital, Women and Infants Hospital of Rhode Island, Brown Medical School, 101 Dudley St, Providence, RI 02905, USA
    FASEB J 15:1921-6. 2001
    ..further demonstrated that betaAR blockade induced a prompt deactivation of the p70 ribosomal protein S6 kinase (p70 S6K). To confirm these results, we measured p70 S6K activity directly...
  57. ncbi S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade
    Usha Narayanan
    Department of Human Genetics, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 283:18478-82. 2008
    ..Here we identify ribosomal protein S6 kinase (S6K1) as a major FMRP kinase in the mouse hippocampus, finding that activity-dependent phosphorylation of FMRP by S6K1 ..
  58. ncbi Involvement of TSC genes and differential expression of other members of the mTOR signaling pathway in oral squamous cell carcinoma
    Sanjukta Chakraborty
    Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, Bangalore, India
    BMC Cancer 8:163. 2008
    ..However, not much is known about the involvement of this pathway in tumorigenesis of OSCC. We therefore investigated the role of the tumor suppressor genes, TSC1 and TSC2, and other members of this pathway in tumorigenesis of OSCC...
  59. ncbi Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats
    Yanbin Zheng
    Section of Endocrinology, The University of Chicago, 900 E 57th Street, KCBD Room 8122, Chicago, Illinois 60637, USA
    J Endocrinol 203:337-47. 2009
    ..The activity of IRS1 serine/threonine kinases - including JNK, ERK, MTOR/p70(S6K) (RPS6KB1 as listed in the MGI Database), glycogen synthase kinase 3beta (GSK3B), AMPK (PRKAA1 as listed in the MGI ..
  60. ncbi Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle
    Zhenqi Liu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, PO Box 801410, Charlottesville, VA 22908 1410, USA
    Am J Physiol Endocrinol Metab 286:E523-8. 2004
    ..A rapamycin-sensitive pathway, most likely acting via ribosomal 70-kDa protein S6 kinase (p70(S6K)), has also been implicated in the regulation of GSK-3 and GS by insulin...
  61. ncbi A p85 subunit-independent p110alpha PI 3-kinase colocalizes with p70 S6 kinase on actin stress fibers and regulates thrombin-stimulated stress fiber formation in swiss 3T3 cells
    S O Johanson
    John Curtin School of Medical Research, Australian National University, Canberra, 2600, Australia
    Exp Cell Res 248:223-33. 1999
    ..Recently our laboratory demonstrated the involvement of p70 S6 kinase (p70(s6k)) activation in thrombin-induced stress fiber formation in Swiss 3T3 cells...
  62. ncbi Acute hyperglycemia rapidly stimulates VEGF mRNA translation in the kidney. Role of angiotensin type 2 receptor (AT2)
    Robert T Day
    O Brien Kidney Research Center, Department of Medicine Nephrology, University of Texas Health Science Center, San Antonio, TX 78229, United States
    Cell Signal 22:1849-57. 2010
    ..The Akt-mTOR-p70(S6K) signaling pathway, involved in the activation of mRNA translation, was activated in hyperglycemic kidneys and was ..
  63. ncbi [The investigations on the relationship between the birth weight of fetus and the P70 S6K as well as mechanism insulin regulate the birth weight of fetus]
    Dong Mei Li
    Department of Obstetrics, Shengjing Hospital of China Medical University, Shenyang 110004, China
    Zhonghua Yi Xue Za Zhi 89:2924-7. 2009
    To investigate the relationship between the birth weight of fetus and the P(70)S6K from ribosome in cells of placental tissues and investigate whether insulin can affect the P(70)S6K by the PI3K/AKT/mTOR (P(70)S6K) signaling pathway in ..
  64. ncbi In vivo role of the phosphate groove of PDK1 defined by knockin mutation
    Barry J Collins
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee, DD1 5EH, UK
    J Cell Sci 118:5023-34. 2005
    ..Agonists stimulate the activation of the AGC kinases p70 ribosomal S6 kinase (S6K), p90 ribosomal S6 kinase (RSK) and serum and glucocorticoid-induced protein kinase (SGK), by inducing the ..
  65. ncbi Immunohistochemical analysis of S6K1 and S6K2 expression in human breast tumors
    Liliya O Savinska
    Institute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine
    Eksp Onkol 26:24-30. 2004
    ..of recombinant S6K2 for biochemical studies; to generate and characterise specific MABs against recombinant S6K2; to study the patterns S6K1 and S6K2 expression and subcellular localization in normal, benign and malignant breast tissues.
  66. ncbi Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation
    K A Martin
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:7892-8. 2001
    ..S6K2 is highly homologous to S6K1 in the core kinase and linker regulatory domains but differs from S6K1 in the N- and C-terminal regions and is ..
  67. ncbi The ubiquitination of ribosomal S6 kinases is independent from the mitogen-induced phosphorylation/activation of the kinase
    J Gwalter
    Research Department of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Int J Biochem Cell Biol 41:828-33. 2009
    ..We have recently demonstrated that steady-state levels of S6K isoforms, S6K1 and S6K2, are regulated by ubiquitination-mediated proteasomal degradation...
  68. ncbi Nutrient sensing in the mTOR/S6K1 signalling pathway
    P Gulati
    Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Biochem Soc Trans 35:236-8. 2007
    Nutrient overload induces constitutive S6K1 (S6 kinase 1) activation, which leads to insulin resistance by suppressing insulin-induced class I PI3K (phosphoinositide 3-kinase) signalling [Um, Frigerio, Watanabe, Picard, Joaquin, Sticker, ..
  69. ncbi Monitoring antitumor efficacy of rapamycin in Kaposi sarcoma
    Salvatore Di Paolo
    Department of Emergency and Organ Transplants, Division of Nephrology, Dialysis and Transplantation, University of Bari, Policlinico Piazza Giulio Cesare, 11 70124 Bari, Italy
    Am J Kidney Dis 49:462-70. 2007
    ....
  70. ncbi The effect of the protein level in a pre-starter diet on the post-hatch performance and activation of ribosomal protein S6 kinase in muscle of neonatal broilers
    Nadia Everaert
    Laboratory for Physiology and Immunology of Domestic Animals, Department of Biosystems, K U Leuven, Kasteelpark Arenberg, 30, 3001 Leuven, Belgium
    Br J Nutr 103:206-11. 2010
    The cytoplasmic serine/threonine ribosomal protein S6 kinase (S6K1) plays a critical role in controlling protein translation...
  71. ncbi ERK and p38 pathways regulate amino acid signalling
    Eduard Casas-Terradellas
    Departament de Ciències Fisiològiques II, IDIBELL, Campus de Bellvitge, Universitat de Barcelona, E 08907, L Hospitalet de Llobregat, Barcelona, Spain
    Biochim Biophys Acta 1783:2241-54. 2008
    The ribosomal protein S6 kinase 1 (S6K1) is emerging as a common downstream target of signalling by hormones and nutrients such as insulin and amino acids. Here, we have investigated how amino acids signal through the S6K1 pathway...
  72. ncbi Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis
    Caterina Nardella
    Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 71:3669-75. 2011
    The S6K1 and S6K2 kinases are considered important mTOR signaling effectors, yet their contribution to tumorigenesis remains unclear...
  73. ncbi S6K1 is acetylated at lysine 516 in response to growth factor stimulation
    Tim R Fenton
    Department of Structural and Molecular Biology, University College London, Gower Street, Darwin Building, London WC1E 6BT, UK
    Biochem Biophys Res Commun 398:400-5. 2010
    The 70kDa ribosomal protein S6 kinase 1 (S6K1) plays important roles in the regulation of protein synthesis, cell growth and metabolism...
  74. ncbi Effects of elevated circulating hormones on resistance exercise-induced Akt signaling
    Barry A Spiering
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA
    Med Sci Sports Exerc 40:1039-48. 2008
    ..We hypothesized that elevated circulating hormones would potentiate the signaling response...
  75. ncbi Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCalpha
    Richard D Byrne
    Division of Cell and Molecular Biology, Imperial College, London SW7 2AZ, United Kingdom
    Cell Signal 19:321-9. 2007
    ..that c48/80 is an effective activator of PI 3-kinases as judged by the increased phosphorylation of PKB and p70(S6K) in fibroblasts in a PI 3-kinase dependent fashion...
  76. ncbi Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo
    T R Fenton
    Research Department of Structural and Molecular Biology, University College London, London, United Kingdom
    Int J Biochem Cell Biol 42:359-66. 2010
    The 70kDa ribosomal protein S6 kinases (S6K1 and S6K2) play important roles in the regulation of protein synthesis, cell growth and survival...
  77. ncbi Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)
    Laura R Pearce
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland, U K
    Biochem J 431:245-55. 2010
    b>S6K1 (p70 ribosomal S6 kinase 1) is activated by insulin and growth factors via the PI3K (phosphoinositide 3-kinase) and mTOR (mammalian target of rapamycin) signalling pathways...
  78. ncbi Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia
    Evrim Erdemoglu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
    Eur J Obstet Gynecol Reprod Biol 145:195-9. 2009
    The effects of metformin on S6K1, which is a crucial effector of mTOR signaling, and on endometrium were studied in a mouse model of endometrial hyperplasia induced by unopposed estradiol or tamoxifen.
  79. ncbi Phosphatidylinositol-3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo(a)pyrene-induced cell cycle alternation via cell cycle regulatory proteins in human embryo lung fibroblasts
    Ai Gao
    National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, 29 Nan Wei Road, Beijing 100050, PR China
    Toxicol Lett 170:30-41. 2007
    ..alternations were accompanied with transactivation of activator protein-1 (AP-1) and phosphorylation of Akt and p70(S6K)...
  80. ncbi Endothelial p70 S6 kinase 1 in regulating tumor angiogenesis
    Ling Zhi Liu
    Department of Pathology, Lab of Reproductive Medicine, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, China
    Cancer Res 68:8183-8. 2008
    The p70 S6 kinase 1 (p70S6K1) exerts its function in regulating protein synthesis, cell proliferation, cell cycle progression, and cell survival in response to growth factors and other cellular signals...
  81. ncbi Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors
    Fumihiko Furuya
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Steroids 74:628-34. 2009
    ..of phosphatidylinositol 3-kinase (PI3K) to activate the downstream AKT-mammalian target of rapamycin (mTOR) and p70(S6K) and PI3K-integrin-linked kinase-matrix metalloproteinase-2 signaling pathways...
  82. ncbi The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer
    X B Trinh
    Translational Cancer Research Group Antwerp, St Augustinus Hospital, Antwerp, Belgium
    Br J Cancer 100:971-8. 2009
    ..Although VEGF-A inhibitors are classified as anti-angiogenic drugs, these data suggest that the working mechanism has an important additional modality of targeting the tumour cells directly...
  83. ncbi Post exercise carbohydrate-protein supplementation: phosphorylation of muscle proteins involved in glycogen synthesis and protein translation
    J L Ivy
    Exercise Physiology and Metabolism Laboratory, Department of Kinesiology and Health Education, The University of Texas, Austin, Texas 78712 0360, USA
    Amino Acids 35:89-97. 2008
    The enzymes Akt, mTOR, p70(S6K), rpS6, GSK3, and glycogen synthase interact in the control of protein and/or glycogen synthesis in skeletal muscle, and each has been found to respond to exercise and nutrient supplementation...
  84. ncbi Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction
    Gemma Vilahur
    Cardiovascular Research Center, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain
    J Mol Cell Cardiol 50:522-33. 2011
    ..P-Bcl2, Bax, P-p53, active-caspase-3); 2) the TLR-4-MyD88-dependent and independent pathways; 3) Akt/mTOR/P70(S6K) axis activation; and, 4) fibrosis (TGF-?, collagen1-A1/A3)...
  85. ncbi Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis
    Benjamin A Corl
    Department of Animal Sciences, North Carolina State University, Raleigh, NC 27695, USA
    J Nutr 138:24-9. 2008
    We previously showed that phosphorylation of p70 S6 kinase (p70(S6k)) in the intestine is increased during viral enteritis...
  86. ncbi Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells
    Stacey A Santi
    Tumor Biology Group, Regional Cancer Program of the Sudbury Regional Hospital, Sudbury, Ontario, Canada
    PLoS ONE 6:e14614. 2011
    ..Currently, the unique role of each Akt isoform and their relevance to human breast cancer are poorly understood...
  87. ncbi S6K1 deficiency protects against apoptosis in hepatocytes
    Agueda Gonzalez-Rodriguez
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, c Arturo Duperier 4, 28029 Madrid, Spain
    Hepatology 50:216-29. 2009
    The mammalian target of rapamycin (mTOR)/S6K1 signaling pathway controls cell growth and proliferation...
  88. ncbi Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones
    Seong Hwan Hwahng
    Innovative Drug Research Center for Metabolic and Inflammatory Disease, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea
    Hepatology 49:1913-25. 2009
    ..protein kinase (AMPK) activators, prevent insulin resistance through AMPK-dependent p70 ribosomal S6 kinase-1 (S6K1) inhibition...
  89. ncbi Protein ingestion further augments S6K1 phosphorylation in skeletal muscle following resistance type exercise in males
    Rene Koopman
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht 6200 MD, The Netherlands
    J Nutr 137:1880-6. 2007
    ..the impact of carbohydrate and/or protein ingestion before and after exercise on ribosomal protein S6 kinase (S6K1) and S6 phosphorylation status in human skeletal muscle tissue. Seven healthy, untrained men (22.5 +/- 0...
  90. ncbi Tissue-specific regulation of S6K1 by insulin in chickens divergently selected for growth
    S Duchêne
    INRA, UR83 Recherches Avicoles, F 37380 Nouzilly, France
    Gen Comp Endocrinol 156:190-8. 2008
    ..Paradoxically, muscle p70 S6 kinase (S6K1), a kinase controlling protein synthesis and growth, was markedly activated in response to insulin...
  91. ncbi VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation
    Henri H Versteeg
    Laboratory for Experimental Internal Medicine and the Department of Oncology, Academic Medical Center, Meibergdreef 9, AZ Amsterdam NL 1105, The Netherlands
    J Biol Chem 277:27065-72. 2002
    ..Here we show that FVIIa induces a transient phosphorylation of p70/p85(S6K) and p90(RSK) in BHK cells stably transfected with either full-length TF or with a cytoplasmic domain-truncated TF ..
  92. ncbi Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression
    Marta López-Peláez
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Madrid, Spain
    Eur J Immunol 41:1733-41. 2011
    LPS stimulation activates IKK and different MAP kinase pathways, as well as the PI3K-Akt-mTOR-p70 S6k pathway, a negative regulator of these MyD88-dependent intracellular signals...
  93. ncbi Glucocorticoids modulate amino acid-induced translation initiation in human skeletal muscle
    Zhenqi Liu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1410, USA
    Am J Physiol Endocrinol Metab 287:E275-81. 2004
    ..of eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1), ribosomal protein S6 kinase (p70(S6K)), and eIF2alpha and the guanine nucleotide exchange activity of eIF2B were measured...
  94. ncbi Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    Kenta Hara
    Biosignal Research Center, Kobe University, 657 8501, Kobe, Japan
    Cell 110:177-89. 2002
    ..elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo...
  95. ncbi The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
    R M Biondi
    Division of Signal Transduction Therapy, MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    EMBO J 20:4380-90. 2001
    PKB/Akt, S6K1 and SGK are related protein kinases activated in a PI 3-kinase-dependent manner in response to insulin/growth factors signalling...
  96. ncbi Oral administration of leucine stimulates phosphorylation of 4E-bP1 and S6K 1 in skeletal muscle but not in liver of diabetic rats
    Fumiaki Yoshizawa
    Department of Animal Science, Faculty of Agriculture, Utsunomiya University, Tochigi, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:59-64. 2002
    ..eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and 70-kDa ribosomal protein S6 kinase (S6K1), two key regulatory proteins involved in the initiation of mRNA translation...
  97. ncbi Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1
    Sopheap Phin
    Department of Biological Sciences, California State University at Long Beach, 1250 Bellflower Blvd, Long Beach, CA 90840, USA
    Biochem J 373:583-91. 2003
    Ribosomal S6 kinase 2 (S6K2) is a serine/threonine kinase identified as a homologue of p70 ribosomal S6 kinase 1 (S6K1)...
  98. ncbi Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity
    T A Diggle
    Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK
    Biochem J 353:621-6. 2001
    ..Our data demonstrate an important role for the phosphorylation of Ser-499 in the activation of eEF-2K by PKA and the inhibition of protein synthesis...
  99. ncbi Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism
    Ivan Nemazanyy
    Department of Structure and Function of Nucleic Acid, The Institute of Molecular Biology and Genetics, 150 Zabolotnogo St, Kyiv 03143, Ukraine
    FEBS Lett 578:357-62. 2004
    ..We demonstrate for the first time that CoA synthase associates specifically with S6K1. The association was observed between native and transiently overexpressed proteins in vivo, as well as by BIAcore ..
  100. ncbi TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and eIF4E in cardiac muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Biochem 94:419-31. 2005
    ..The phosphorylation of mTOR, S6K1, the ribosomal protein (rp) S6, and eIF4G was not altered in hearts from septic rats under basal conditions...
  101. ncbi The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin
    Lloyd P McMahon
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 22:7428-38. 2002
    ..controls mRNA translation initiation by modulating phosphorylation of the translational regulators PHAS-I and p70(S6K). Here we show that in vitro mTOR is able to phosphorylate these two regulators at comparable rates...

Research Grants72

  1. Amino Acids and Muscle Protein Synthesis
    Robert Wolfe; Fiscal Year: 2006
    ..in an increased phosphorylation of the eIF4E binding protein 1 (4E-BP1) and the 70KDa ribosomal protein S6 kinase (S6K1)...
  2. Mechanism of thrombin-induced tolerance to brain injury
    Guohua Xi; Fiscal Year: 2010
    ..a thrombin receptor) and the activation of phosphatidylinositol 3 kinase (PI3K)/ ribosomal protein S6 kinases (p70 S6K) and extracellular signal-regulated kinases (ERK)/p70 S6K pathways in mediating protection from neuronal death ..
  3. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2005
    ..found that the mitogenic pathway involving phosphotidylinositol-3 kinase (P13K) and ribosomal protein S6 kinase 1 (S6K1) is inactivated in fetal liver, but that an alternative mechanism exists for maintaining the hyperphosphorylation ..
  4. Mechanisms of S6K1 Mediated Insulin Resistance
    George Thomas; Fiscal Year: 2007
    ..Here we provide preliminary data in the mouse, showing that one such component, ribosomal protein S6 kinase 1 (S6K1), plays not only a positive role in insulin-induced anabolic responses associated with cell growth, but also a ..
  5. Mechanisms of S6K1 Mediated Insulin Resistance
    George Thomas; Fiscal Year: 2010
    ..Here we provide preliminary data in the mouse, showing that one such component, ribosomal protein S6 kinase 1 (S6K1), plays not only a positive role in insulin-induced anabolic responses associated with cell growth, but also a ..
  6. Alcohol Consumption and Risk of NHL: Role of MTOR Dysfunction
    RONALD BENJAMIN GARTENHAUS; Fiscal Year: 2010
    ..There is recent evidence suggesting that chronic alcohol intake is associated with suppression of the mTOR/p70 S6K signaling pathway, a pathway that plays key roles in the control of important cellular processes, including cell ..
  7. Alcohol Consumption and Risk of NHL: Role of MTOR Dysfunction
    Ronald Gartenhaus; Fiscal Year: 2009
    ..There is recent evidence suggesting that chronic alcohol intake is associated with suppression of the mTOR/p70 S6K signaling pathway, a pathway that plays key roles in the control of important cellular processes, including cell ..
  8. Mitotic Regulation of Ribosomal S6 Protein Kinases
    Omar Shah; Fiscal Year: 2004
    ..Three S6 kinases (p70S6K1, p85S6K2, and p54S6K2) derived from two separate genes (S6K1 and S6K2) are currently known, all of which share ..
  9. Pharmacodynamic-guided Dose-finding Study of Rapamycin
    Manuel Hidalgo; Fiscal Year: 2005
    ..In Specific Aim # 2 we will confirm that the dose selected in Specific Aim # 1 is effective in inhibiting S6K activity in pair tumor biopsies...
  10. Autophagy and protein translation in neural function & neurodegeneration
    Albert R La Spada; Fiscal Year: 2010
    ..proteinopathy, by crossing HD mice onto a reduced protein translation background, using two different models (S6K1 null and 4E-BP1 transgenic mice)...
  11. Autophagy and protein translation in neural function & neurodegeneration
    Albert La Spada; Fiscal Year: 2009
    ..proteinopathy, by crossing HD mice onto a reduced protein translation background, using two different models (S6K1 null and 4E-BP1 transgenic mice)...
  12. Genetics of Wing and Cell-Size Evolution in Nasonia
    John Werren; Fiscal Year: 2007
    ..5% of the genome, approximately 1.7Mb. We have also mapped several insulin-signaling genes, two of which (e.g. s6k, tor) map closely to loci involved in the wing size differences...
  13. SIGNAL TRANSDUCTION TO PP70 S6K
    John Blenis; Fiscal Year: 1999
    ....
  14. Role of Leucine Metabolism in Leucine Signaling
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2010
    ..Further, substrates of mTOR, lipin, S6K1 and 4EBP1&2, have been alternatively implicated in either obesity or resistance to obesity...
  15. Role of Leucine Metabolism in Leucine Signaling
    Christopher Lynch; Fiscal Year: 2009
    ..Further, substrates of mTOR, lipin, S6K1 and 4EBP1&2, have been alternatively implicated in either obesity or resistance to obesity...
  16. Role of Leucine Metabolism in Leucine Signaling
    Christopher Lynch; Fiscal Year: 2007
    ..Further, substrates of mTOR, lipin, S6K1 and 4EBP1&2, have been alternatively implicated in either obesity or resistance to obesity...
  17. Cytokine Regulation of Muscle Protein Synthesis During Infection
    Charles H Lang; Fiscal Year: 2010
    ..basal conditions and in response to leucine by determining whether sepsis alters the interaction of 4E-BP1 and S6K1 with the scaffold protein raptor, the binding activity of the eIF3 scaffolding complex, and/or the binding of PDCD4 ..
  18. Cytokine Regulation of Muscle Protein Synthesis During Infection
    Charles Lang; Fiscal Year: 2009
    ..basal conditions and in response to leucine by determining whether sepsis alters the interaction of 4E-BP1 and S6K1 with the scaffold protein raptor, the binding activity of the eIF3 scaffolding complex, and/or the binding of PDCD4 ..
  19. Integrin-collagen signaling and control of fibroblast proliferation
    Craig A Henke; Fiscal Year: 2010
    ..This leads to unrestrained PI3K/Akt/S6K1 activity and underlies the pathologic proliferation of IPF fibroblasts on polymerized collagen...
  20. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2007
    ..target of rapamycin (mTOR), a serine/threonine kinase that controls phosphorylation of two other protein factors S6K1 and 4E-BP1 that regulate mRNA translation and formation of an active elF4E-elF4G complex and elF4G phosphorylation...
  21. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2009
    ..target of rapamycin (mTOR), a serine/threonine kinase that controls phosphorylation of two other protein factors S6K1 and 4E-BP1 that regulate mRNA translation and formation of an active elF4E-elF4G complex and elF4G phosphorylation...
  22. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    Scot R Kimball; Fiscal Year: 2010
    ..target of rapamycin (mTOR), a serine/threonine kinase that controls phosphorylation of two other protein factors S6K1 and 4E-BP1 that regulate mRNA translation and formation of an active elF4E-elF4G complex and elF4G phosphorylation...
  23. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2007
    ..target of rapamycin (mTOR), a serine/threonine kinase that controls phosphorylation of two other protein factors S6K1 and 4E-BP1 that regulate mRNA translation and formation of an active elF4E-e!F4G complex and elF4G phosphorylation...
  24. Tuberin and hamartin in rapamycin-sensitive & rapamycin-insensitive smooth muscle
    Geraldine A Finlay; Fiscal Year: 2010
    ..enriched in brain), with downstream constitutive activation of mTOR (mammalian target of rapamycin), S6Kinase (S6K) and S6, leading to increased cellular growth...
  25. Tuberin and hamartin in rapamycin-sensitive & rapamycin-insensitive smooth muscle
    Geraldine Finlay; Fiscal Year: 2009
    ..enriched in brain), with downstream constitutive activation of mTOR (mammalian target of rapamycin), S6Kinase (S6K) and S6, leading to increased cellular growth...
  26. mTOR in Growth and Protection of Hypertrophying Myocardium
    Dhandapani Kuppuswamy; Fiscal Year: 2011
    ..Akt (protein kinase B) via UPS, and mTORC1, which regulates protein translation and cell size via molecules such as S6K1 and its recently identified substrate, SKAR (S6K1 Aly/REF-like target)...
  27. The Role of TSC2 and Rho GTPases in LAM
    VERA KRYMSKAYA; Fiscal Year: 2009
    ..tuberous sclerosis complex 2 (TSC2) as a negative regulator of mammalian target of rapamycin (mTOR)/p70 S6 kinase (S6K1) in LAM. These pre-clinical findings led to a Phase 2 rapamycin clinical trial for LAM patients...
  28. mTOR in Growth and Protection of Hypertrophying Myocardium
    Dhandapani Kuppuswamy; Fiscal Year: 2010
    ..Akt (protein kinase B) via UPS, and mTORC1, which regulates protein translation and cell size via molecules such as S6K1 and its recently identified substrate, SKAR (S6K1 Aly/REF-like target)...
  29. The Role of TSC2 and Rho GTPases in LAM
    Vera P Krymskaya; Fiscal Year: 2010
    ..tuberous sclerosis complex 2 (TSC2) as a negative regulator of mammalian target of rapamycin (mTOR)/p70 S6 kinase (S6K1) in LAM. These pre-clinical findings led to a Phase 2 rapamycin clinical trial for LAM patients...
  30. RGS: A Molecular Switch Regulating Irreversible ASM Growth/Contraction in Asthma
    REYNOLD ALEXANDER PANETTIERI; Fiscal Year: 2010
    ..Growth factors require activation of Src, phosphatidylinositol 3-kinase (PI3K) and S6K1 to stimulate ASM growth...
  31. RGS: A Molecular Switch Regulating Irreversible ASM Growth/Contraction in Asthma
    Reynold Panettieri; Fiscal Year: 2009
    ..Growth factors require activation of Src, phosphatidylinositol 3-kinase (PI3K) and S6K1 to stimulate ASM growth...
  32. Interrupting Akt-S6K1 metabolic control to enhance apoptotic responses in CML
    David R Plas; Fiscal Year: 2010
    ..data in this proposal show that Akt signals increased metabolism and survival through the downstream protein kinase S6K1. Interestingly, S6K1 is also a negative regulator of upstream elements in the PI3K/Akt pathway, acting in a ..
  33. Molecular Pathogenesis of the Hamartoma Syndromes
    David Kwiatkowski; Fiscal Year: 2007
    ..approach for tumors arising in mouse models of PJS and TSC; Project 3 (Perrimon) -- Dissection of Tsc1/Tsc2/TOR/S6K Signaling in Drosophila: perform hypothesis driven RNAi screens to identify additional pathway components and ..
  34. Role of adipocytokines, leptin and adiponectin in breast carcinogenesis
    Dipali Sharma; Fiscal Year: 2010
    ..Adiponectin activates AMPK in an LKB1-dependent manner, and inhibits S6K activation demonstrating the involvement of LKB1-AMPK-S6K axis...