OLR1

Summary

Gene Symbol: OLR1
Description: oxidized low density lipoprotein (lectin-like) receptor 1
Alias: CLEC8A, LOX1, LOXIN, SCARE1, SLOX1, C-type lectin domain family 8 member A, hLOX-1, lectin-type oxidized LDL receptor 1, ox LDL receptor 1, oxidized low-density lipoprotein receptor 1, oxidized low-density lipoprotein receptor 1, soluble form, scavenger receptor class E, member 1
Species: human

Top Publications

  1. ncbi An endothelial receptor for oxidized low-density lipoprotein
    T Sawamura
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan
    Nature 386:73-7. 1997
  2. ncbi The splice variant LOXIN inhibits LOX-1 receptor function through hetero-oligomerization
    Silvia Biocca
    Department of Neuroscience and Laboratory of Clinical Biochemistry, University of Tor Vergata, Rome, Italy
    J Mol Cell Cardiol 44:561-70. 2008
  3. ncbi Lox-1: the multifunctional receptor underlying cardiovascular dysfunction
    Sayoko Ogura
    Department of Vascular Physiology, National Cardiovascular Center, Suita, Japan
    Circ J 73:1993-9. 2009
  4. ncbi In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction
    Ruggiero Mango
    Department of Biopathology and Diagnostic Imaging, University of Tor Vergata, Via Montpellier 1, Rome, Italy
    Circ Res 97:152-8. 2005
  5. ncbi Lectin-like oxidized LDL receptor-1 (LOX-1) supports adhesion of mononuclear leukocytes and a monocyte-like cell line THP-1 cells under static and flow conditions
    Kazutaka Hayashida
    Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    FEBS Lett 511:133-8. 2002
  6. ncbi On the association of the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction or coronary artery disease
    Elisabetta Trabetti
    Department of Mother and Child and of Biology Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy
    Eur J Hum Genet 14:127-30. 2006
  7. ncbi LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells
    Dayuan Li
    Department of Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Arterioscler Thromb Vasc Biol 23:816-21. 2003
  8. ncbi Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cells: the potential role of transcription factor NF-kappaB
    D Li
    Departments of Medicine and Physiology, University of Arkansas and VA Medical Center, Little Rock, USA
    Circulation 102:1970-6. 2000
  9. ncbi Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction
    Mariko Tatsuguchi
    The Heart Institute of Japan, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Biochem Biophys Res Commun 303:247-50. 2003
  10. ncbi Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions
    H Kataoka
    Departments of Geriatric Medicine, and Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circulation 99:3110-7. 1999

Research Grants

  1. 15-LOX-15(S)-HETE axis and angiogenesis
    Gadiparthi N Rao; Fiscal Year: 2010
  2. RECEPTOR FOR GP96 ON MACROPHAGES AND DENDRITIC CELLS
    Pramod Srivastava; Fiscal Year: 2007
  3. EICOSANOIDS AND VASCULAR WALL REMODELING
    Gadiparthi N Rao; Fiscal Year: 2010
  4. DNA Diagnostics for Minimizing Metabolic Side-Effects of Antipsychotics
    GUALBERTO RUANO; Fiscal Year: 2007
  5. Physiogenomic Arrays for Clinical Neuropsychiatry
    GUALBERTO RUANO; Fiscal Year: 2006
  6. OXIDANT STRESS AND ENDOTHELIAL CELL METABOLISM
    LORRAINE SORDILLO; Fiscal Year: 2001

Scientific Experts

Detail Information

Publications136 found, 100 shown here

  1. ncbi An endothelial receptor for oxidized low-density lipoprotein
    T Sawamura
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan
    Nature 386:73-7. 1997
    ..The cloned receptor is a membrane protein that belongs structurally to the C-type lectin family, and is expressed in vivo in vascular endothelium and vascular-rich organs...
  2. ncbi The splice variant LOXIN inhibits LOX-1 receptor function through hetero-oligomerization
    Silvia Biocca
    Department of Neuroscience and Laboratory of Clinical Biochemistry, University of Tor Vergata, Rome, Italy
    J Mol Cell Cardiol 44:561-70. 2008
    ..We have recently identified a truncated naturally occurring variant of the human receptor LOX-1, named LOXIN, which lacks part of the C-terminus lectin-like domain...
  3. ncbi Lox-1: the multifunctional receptor underlying cardiovascular dysfunction
    Sayoko Ogura
    Department of Vascular Physiology, National Cardiovascular Center, Suita, Japan
    Circ J 73:1993-9. 2009
    ..Furthermore, LOX-1-related tools might open new gateways from diagnosis to therapeutics for cardiovascular diseases...
  4. ncbi In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction
    Ruggiero Mango
    Department of Biopathology and Diagnostic Imaging, University of Tor Vergata, Via Montpellier 1, Rome, Italy
    Circ Res 97:152-8. 2005
    ..that intronic SNPs, linked to MI, regulate the expression of a new functional splicing isoform of the OLR1 gene, LOXIN, which lacks exon 5...
  5. ncbi Lectin-like oxidized LDL receptor-1 (LOX-1) supports adhesion of mononuclear leukocytes and a monocyte-like cell line THP-1 cells under static and flow conditions
    Kazutaka Hayashida
    Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    FEBS Lett 511:133-8. 2002
    ..Taken together, LOX-1 can work as a cell surface receptor for mononuclear leukocytes under both static and flow conditions...
  6. ncbi On the association of the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction or coronary artery disease
    Elisabetta Trabetti
    Department of Mother and Child and of Biology Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy
    Eur J Hum Genet 14:127-30. 2006
    The human oxidised low-density lipoprotein receptor 1 (OLR1) gene is a functional candidate for atherosclerosis...
  7. ncbi LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells
    Dayuan Li
    Department of Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Arterioscler Thromb Vasc Biol 23:816-21. 2003
    ..We examined the role of LOX-1, a receptor for oxidized (ox) LDL, in the expression of CD40/CD40L in cultured human coronary artery endothelial cells (HCAECs)...
  8. ncbi Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cells: the potential role of transcription factor NF-kappaB
    D Li
    Departments of Medicine and Physiology, University of Arkansas and VA Medical Center, Little Rock, USA
    Circulation 102:1970-6. 2000
    ..In this study, we investigated the regulation of Ang II receptors (AT1R and AT2R) by ox-LDL and the role of the redox-sensitive transcription factor NF-kappaB in this process...
  9. ncbi Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction
    Mariko Tatsuguchi
    The Heart Institute of Japan, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Biochem Biophys Res Commun 303:247-50. 2003
    Lectin-like oxidized low-density lipoprotein receptor (LOX-1/OLR1) has been suggested to play a role in the progression of atherogenesis...
  10. ncbi Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions
    H Kataoka
    Departments of Geriatric Medicine, and Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circulation 99:3110-7. 1999
    ..The relationship of this novel receptor for Ox-LDL to atherogenesis, however, has not yet been clarified. In this study, we explored the expression of LOX-1 in the atherosclerotic lesions of human carotid arteries...
  11. ncbi Elevated soluble lectin-like oxidized LDL receptor-1 (sLOX-1) levels in obese postmenopausal women
    Tina E Brinkley
    Department of Kinesiology, University of Maryland, College Park, Maryland, USA
    Obesity (Silver Spring) 16:1454-6. 2008
    ..In conclusion, obese women have higher sLOX-1 levels, which may reflect increased LOX-1 expression in adipose tissue...
  12. ncbi An oxidized low-density lipoprotein receptor gene variant is inversely associated with the severity of coronary artery disease
    Reiko Ohmori
    First Department of Internal Medicine, National Defense Medical College, Saitama, Japan
    Clin Cardiol 27:641-4. 2004
    ..The expression of LOX-1 was shown to be upregulated in atherosclerotic lesions. Recently, LOX-1 gene polymorphism (G501C) was reported to be associated with myocardial infarction (MI)...
  13. ncbi Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD
    Joshua W Knowles
    Division of Cardiovascular Medicine, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
    BMC Med Genet 9:23. 2008
    The lectin-like oxidized LDL receptor LOX-1 (encoded by OLR1) is believed to play a key role in atherogenesis and some reports suggest an association of OLR1 polymorphisms with myocardial infarction (MI)...
  14. ncbi The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1
    HaJeung Park
    Biomolecular Crystallography Group, Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 280:13593-9. 2005
    ..Based on the arrangement of critical binding residues on the Lox-1 structure, we propose a binding mode for the recognition of modified low density lipoprotein and other Lox-1 ligands...
  15. ncbi The 3'-UTR C>T polymorphism of the oxidized LDL-receptor 1 (OLR1) gene does not associate with coronary artery disease in Italian CAD patients or with the severity of coronary disease
    Federica Sentinelli
    Department of Clinical Sciences, Institute of Clinical Medicine, Division of Endocrinology, University of Rome La Sapienza, Rome, Italy
    Nutr Metab Cardiovasc Dis 16:345-52. 2006
    ..endothelial cells internalize and degrade oxLDL through the endothelial lectin-like oxidized LDL receptor 1 (OLR1)...
  16. ncbi Human lectin-like oxidized low-density lipoprotein receptor-1 functions as a dimer in living cells
    Qiuhong Xie
    National Food Research Institute, Tsukuba, Ibaraki 305 8642, Japan
    DNA Cell Biol 23:111-7. 2004
    ..These results provide the first evidence for the existence of hLOX-1 dimers/oligomers...
  17. ncbi Association of single nucleotide polymorphisms in the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction
    R Mango
    J Med Genet 40:933-6. 2003
  18. ncbi Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to OxLDL
    Izuru Ohki
    Department of Structural Biology, Biomolecular Engineering Research Institute 6 2 3, Furuedai, Suita, Osaka, 565 0874, Japan
    Structure 13:905-17. 2005
    ..Based on the LDL model structure, possible binding modes of LOX-1 to OxLDL are proposed...
  19. ncbi Small concentrations of oxLDL induce capillary tube formation from endothelial cells via LOX-1-dependent redox-sensitive pathway
    Abhijit Dandapat
    Department of Cardiovascular Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Ark 72205 7199, USA
    Arterioscler Thromb Vasc Biol 27:2435-42. 2007
    ..Low levels of reactive oxygen species (ROS) function as signaling molecules for angiogenesis. We postulated that low concentrations of oxLDL might induce low levels of ROS and initiate angiogenesis...
  20. ncbi Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor
    H Yoshida
    University of California, San Diego, Department of Medicine, 0682, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Biochem J 334:9-13. 1998
    ..These results suggest that differentiation induces the expression of LOX-1 in macrophages, where it may play a role as a scavenger receptor and/or a receptor for oxidized LDL...
  21. ncbi Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease
    Qi Chen
    Department of Human Genetics, University of Pittsburgh, PA 15261, USA
    Circulation 107:3146-51. 2003
    We examined the association of 3 polymorphisms in the lectin-like oxidized LDL receptor-1 (LOX1 or OLR1) gene with coronary artery disease in the Women's Ischemia Syndrome Evaluation (WISE) study population.
  22. ncbi Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene
    T Aoyama
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan
    Biochem J 339:177-84. 1999
    ..3-p13.2 region of chromosome 12. Since the locus for a familial hypertension has been mapped to the overlapping region, LOX-1 might be the gene responsible for the hypertension...
  23. ncbi Single-nucleotide polymorphism typing based on pyrosequencing chemistry and acryl-modified glass chip
    Huan Huang
    China Pharmaceutical University, Nanjing, P R China
    Electrophoresis 30:991-8. 2009
    ..25 microL of PCR products can give a successful genotyping. To evaluate the method, four SNPs, OLR1-C15577T, OLR1-C14417G, PPARG-Pro12Ala, and PPARG-C2821T, were detected...
  24. ncbi Changes of oxidase and hydrolase activities in pecan leaves elicited by black pecan aphid (Hemiptera: Aphididae) feeding
    Yigen Chen
    Department of Entomology, University of Georgia, Griffin, GA 30223, USA
    J Econ Entomol 102:1262-9. 2009
    ..feeding also influences activity of two lipoxygenase isozymes, with LOX3 being more frequently induced than LOX1. Foliar LOX3 activity was more frequently induced by M...
  25. ncbi Continuous measurement of the lipoxygenase-catalyzed oxidation of unsaturated lipids using the monomolecular film technique
    Abdelkarim Abousalham
    Enzymology at Interfaces and Physiology of Lipolysis, UPR 9025 CNRS, 31, Chemin Joseph Aiguier, 13402 Marseille, Cedex 20, France
    Pharm Res 23:2469-74. 2006
    ..presents the first detailed kinetic investigation involving the continuous measurement of the soybean lipoxygenase 1 (LOX1)-catalyzed oxidation of unsaturated lipids using the monomolecular film technique at an argon/water interface.
  26. ncbi Identification of natural killer cell receptor clusters in the platypus genome reveals an expansion of C-type lectin genes
    Emily S W Wong
    Faculty of Veterinary Science, University of Sydney, B19 RMC Gunn, Sydney, NSW, 2006, Australia
    Immunogenetics 61:565-79. 2009
    ..Many have arisen as the result of a lineage-specific expansion. Orthologs of OLR1, CD69, KLRE, CLEC12B, and CLEC16p genes were also identified...
  27. ncbi 15(S)-HETE production in human retinal microvascular endothelial cells by hypoxia: Novel role for MEK1 in 15(S)-HETE induced angiogenesis
    Arun K Bajpai
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Invest Ophthalmol Vis Sci 48:4930-8. 2007
    To examine for the expression of 15-lipoxygenase 1 (15-LOX1) and 15-LOX2 in human retinal microvascular endothelial cells (HRMVECs) and study the role of arachidonic acid metabolites of these enzymes in angiogenesis.
  28. ncbi Lipoxygenase metabolites modulate vascular-derived platelet activating factor production following endotoxin challenge
    C M Corl
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA
    Vet Immunol Immunopathol 136:98-107. 2010
    ..This study sought to determine if eicosanoids derived from the 15-lipoxygenase (15-LOX1) pathway can modulate the biosynthesis of PAF in cultured bovine aortic endothelial cells (BAEC) following ..
  29. ncbi Characterization of three potato lipoxygenases with distinct enzymatic activities and different organ-specific and wound-regulated expression patterns
    J Royo
    Centro Nacional de Biotecnologia CSIC, Campus Cantoblanco UAM, Carretera Colmenar Viejo km 15, 500, 28049 Madrid, Spain
    J Biol Chem 271:21012-9. 1996
    ..From their deduced amino acid sequences, three distinct classes are defined (Lox1, Lox2, and Lox3)...
  30. ncbi Identification of a methyl jasmonate-responsive region in the promoter of a lipoxygenase 1 gene expressed in barley grain
    J Rouster
    Carlsberg Research Laboratory, Copenhagen, Denmark
    Plant J 11:513-23. 1997
    ..b>Lox1 transcription was shown to be methyl jasmonate (MeJA)- and wound-inducible in leaves, but Lox1 transcripts were not ..
  31. ncbi Anti-beta2GPI-antibody-induced endothelial cell gene expression profiling reveals induction of novel pro-inflammatory genes potentially involved in primary antiphospholipid syndrome
    C Hamid
    Research Institute of Healthcare Sciences, University of Wolverhampton, UK
    Ann Rheum Dis 66:1000-7. 2007
    ..To determine the effects of primary antiphospholipid syndrome (PAPS)-derived anti-beta(2)GPI antibodies on gene expression in human umbilical vein endothelial cells (HUVEC) by gene profiling using microarrays...
  32. ncbi Robust immunohistochemical staining of several classes of proteins in tissues subjected to autolysis
    Joseph Maleszewski
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Histochem Cytochem 55:597-606. 2007
    ..The robustness of signal for 16 proteins (MMP1, MMP2, MMP3, MMP9, TIMP1, TIMP2, TIMP3, AGER, MSR, SCARB1, OLR1, CD36, LTF, LGALS3, LYZ, and DDOST) and two measures of advanced glycation end products (AGE, CML) was evaluated...
  33. ncbi Conformational flexibility in mammalian 15S-lipoxygenase: Reinterpretation of the crystallographic data
    Jongkeun Choi
    Department of Chemistry, Seoul National University, Seoul, Korea
    Proteins 70:1023-32. 2008
    ..The crystal structure of rabbit 15S-LOX1 that was reported by Gillmor et al. in 1997 has played key roles for understanding the properties of mammalian LOXs...
  34. ncbi Compact spheroid formation by ovarian cancer cells is associated with contractile behavior and an invasive phenotype
    Katharine L Sodek
    Department of Cell and Systems Biology, University of Toronto, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Int J Cancer 124:2060-70. 2009
    ..beta1 integrin function, including fibronectin (FN), connective tissue growth factor (CTGF/CCN2), lysyl oxidase (LOX1), tissue transglutaminase 2 (TGM2) and urinary plasminogen activator receptor (uPAR)...
  35. ncbi A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2
    M Renedo
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, Madrid, 28006, Spain
    Genomics 65:129-36. 2000
    ..symbol KLRG1)-A2M-PZP-A2MP-NKRP1A (HGMW-approved symbol KLRB1)-CD69-AICL (HGMW-approved symbol CLECSF2)-KLRF1-OLR1-CD94 (HGMW-approved symbol KLRD1)-NKG2D (HGMW-approved symbol D12S2489E)-PGFL-NKG2F (HGMW-approved symbol KLRC4)-..
  36. ncbi A mitogen-activated protein kinase gene, AhMPK3 of peanut: molecular cloning, genomic organization, and heterologous expression conferring resistance against Spodoptera litura in tobacco
    Koppolu Raja Rajesh Kumar
    Department of Plant Sciences, University of Hyderabad, Hyderabad 500046, India
    Mol Genet Genomics 282:65-81. 2009
    ..larvae of Spodoptera litura and constitutively higher transcript levels of defense response genes like PR1a, PR1b, LOX1, PI-II etc...
  37. ncbi A cell-based assay for screening lipoxygenase inhibitors
    Dileep G Nair
    Department of Physiology and Biochemistry, Queen s University, Kingston, ON, Canada
    Prostaglandins Other Lipid Mediat 90:98-104. 2009
    ..5-LOX, "platelet-type" 12-LOX (p12-LOX) and 15-LOX type 1 (15-LOX1), originally identified in leukocytes, platelets, and reticulocytes, respectively, generate lipid mediators ..
  38. ncbi Association of the OLR1 gene with milk composition in Holstein dairy cattle
    H Khatib
    Department of Dairy Science, University of Wisconsin, Madison 53706, USA
    J Dairy Sci 89:1753-60. 2006
    Oxidized low-density lipoprotein receptor (OLR1) is the major protein that binds, internalizes, and degrades oxidized low-density lipoprotein...
  39. ncbi Soybean seed lipoxygenase genes: molecular characterization and development of molecular marker assays
    Julian M Lenis
    Division of Plant Sciences, University of Missouri, 108 Waters Hall, Columbia, MO 65211, USA
    Theor Appl Genet 120:1139-49. 2010
    Soybean seeds contain three lipoxygenase (Lox) enzymes that are controlled by separate genes, Lox1, Lox2 and Lox3...
  40. ncbi Relationship between lectin-like oxidized low-density lipoprotein receptor 1 expression and preoperative echogenic findings of vulnerable carotid plaque
    Atsushi Saito
    Tohoku University Hospital Emergency Center, Konan Hospital, Sendai, Japan
    Acta Neurochir (Wien) 152:589-95. 2010
    Lectin-like oxidized low-density lipoprotein 1 (LOX1) is an important cell surface receptor for the progression of atherosclerosis...
  41. ncbi Selenium inhibits 15-hydroperoxyoctadecadienoic acid-induced intracellular adhesion molecule expression in aortic endothelial cells
    Lorraine M Sordillo
    Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824, USA
    Free Radic Biol Med 44:34-43. 2008
    ..The 15-lipoxygenase 1 (15-LOX1) pathway can generate several proinflammatory eicosanoids that are known to enhance ICAM-1 expression within the ..
  42. ncbi Dual positional and stereospecificity of lipoxygenase isoenzymes from germinating barley (green malt): biotransformation of free and esterified linoleic acid
    Leif Alexander Garbe
    Institut fur Biotechnologie, Molekularanalytik, Technische Universitat Berlin, Seestrasse 13, D 13353 Berlin, Germany
    J Agric Food Chem 54:946-55. 2006
    The lipoxygenase isoenzymes LOX1 and LOX2 from green malt were separated by isoelectric focusing, and their catalytic properties regarding complex lipids as substrates were characterized...
  43. ncbi Genotyping OLR1 gene: a genomic biomarker for cardiovascular diseases
    Lucia Vecchione
    Department of Biopathology and Diagnostic Imaging, Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, University of Tor Vergata, Rome, Italy
    Recent Pat Cardiovasc Drug Discov 2:147-51. 2007
    ..to myocardial infarction, regulate the expression of a new functional splicing isoform of the OLR1 gene, called LOXIN. The ratio OLR1/LOXIN mRNA is increased in subjects carrying the risk haplotype...
  44. ncbi Lectin-like oxidized low-density lipoprotein receptor 1 and matrix metalloproteinase expression in ruptured and unruptured multiple dissections of distal middle cerebral artery: case report
    Atsushi Saito
    Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 1 1 Seiryomachi, Aoba, Sendai, Miyagi, 980 8574, Japan
    Acta Neurochir (Wien) 152:1235-40. 2010
    Oxidized low-density lipoprotein receptor 1 (LOX1) is a critical factor for atherosclerosis in a variety of vascular diseases; however, its major role in cerebral arterial dissecting aneurysm is unclear.
  45. ncbi Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration
    Harihara S K Potula
    Department of Physiology, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 284:31142-55. 2009
    To understand the role of human 15-lipoxygenase 1 (15-LOX1) in vascular wall remodeling, we have studied the effect of the major 15-LOX1 metabolite of arachidonic acid, 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), on vascular smooth ..
  46. ncbi A novel lipoxygenase in pea roots. Its function in wounding and biotic stress
    Pasqua Veronico
    Institute of Plant Protection, Bari Section, Consiglio Nazionale delle Ricerche, 70126 Bari, Italy
    Plant Physiol 141:1045-55. 2006
    ..The predicted LOXN2 structure lacked a loop present in soybean (Glycine max) LOX1, in a position consistent with control of the degree of substrate access to the catalytic site and for LOXN2's dual ..
  47. ncbi Effect of ABCG2, PPARGC1A, OLR1 and SCD1 gene polymorphism on estimated breeding values for functional and production traits in Polish Holstein-Friesian bulls
    J Komisarek
    Department of Cattle Breeding and Milk Production, Poznan University of Life Sciences, Poznan, Poland
    J Appl Genet 50:125-32. 2009
    This study investigated the impact of 6 polymorphisms located in the ABCG2, PPARGC1A, OLR1 and SCD1 genes on estimated breeding values for milk production, longevity, somatic cell count and reproductive traits...
  48. ncbi CD36 mRNA expression is increased in CD14+ monocytes of patients with coronary heart disease
    D Teupser
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    Clin Exp Pharmacol Physiol 35:552-6. 2008
    ..MSR1), scavenger receptor class B member 1 (SRB1), lectin-like oxidized low-density lipoprotein (LDL) receptor 1 (LOX1), CD36, LDL receptor (LDLR)), reverse cholesterol transport (apolipoprotein E (ApoE), ATP-binding cassette sub-..
  49. ncbi Molecular enzymology of lipoxygenases
    Igor Ivanov
    Institute of Biochemistry, University Medicine Berlin Charite, Germany
    Arch Biochem Biophys 503:161-74. 2010
    ..Although soybean LOX1 was discovered more than 60years ago, the structural biology of these enzymes was not studied until the mid 1990s...
  50. ncbi [New insights in atherosclerosis research: LOX-1, leading actor of cardiovascular diseases]
    G Novelli
    Dipartimento di Biopatologia e Diagnostica per Immagini, Universita di Roma Tor Vergata, Italia
    Clin Ter 158:239-48. 2007
    The OLR1 gene encodes a cell-surface endocytosis receptor (LOX-1) for oxidized low density lipoprotein (OxLDL)...
  51. ncbi A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases
    Heather A Hirsch
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 17:348-61. 2010
    ..As in atherosclerosis, oxidized LDL and its receptor OLR1 activate the inflammatory pathway through NF-kappaB, leading to transformation...
  52. ncbi Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis
    Yasushi Ishigaki
    Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan
    Circulation 118:75-83. 2008
    ..In addition, oxidized LDL (oxLDL) is suggested to play roles in the formation and progression of atherosclerosis. However, whether lowering oxLDL alone, rather than total LDL, affects atherogenesis remains unclear...
  53. ncbi Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells
    P Hermanz-Falcón
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
    Immunogenetics 53:288-95. 2001
    ..The DECTIN-1 gene was localized in the natural killer gene complex on human Chromosome 12p12.3-p13.2, between OLR1 and CD94 (position 21.8 cM on the genetic map)...
  54. ncbi Candidate genes for late-onset Alzheimer's disease: focus on chromosome 12
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Mech Ageing Dev 127:36-47. 2006
    ..Polymorphisms in different susceptibility genes on chromosome 12 (A2M, LRP1, CP2 and OLR1) are now being suggested as possible genetic markers for increased risk of developing AD...
  55. ncbi Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson St, Hartford, CT, United States
    Clin Chim Acta 400:48-55. 2009
    ..The balance of efficacy and safety of TZD varies widely from patient to patient. Genetic variability may reveal pathophysiological pathways underlying weight gain associated with TZD therapy and due to adiposity and/or edema...
  56. ncbi The role of vascular factors in late-onset sporadic Alzheimer's disease. Genetic and molecular aspects
    A Rocchi
    Department of Neuroscience, Neurological Clinic, University of Pisa, Italy
    Curr Alzheimer Res 6:224-37. 2009
    ..Other possible genes include VLDL-R, LRP, NOS3, CST3, OLR1, MTHFR, PON1 and VEGF, but many of the related studies have shown conflicting results...
  57. ncbi Molecular cloning and biochemical characterization of a lipoxygenase in almond (Prunus dulcis) seed
    G Mita
    Istituto di Ricerca sulle Biotecnologie Agroalimentari, C N R, Lecce, Italy
    Eur J Biochem 268:1500-7. 2001
    ..0 kDa and a predicted pI of 5.61. Almond seed lipoxygenase shows 71% identity with an Arabidopsis LOX1 gene and is closely related to tomato fruit and potato tuber lipoxygenases...
  58. ncbi [Development of a new type soybean germplasm with null lipoxygenase isozymes]
    Fen Xia Han
    Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Key Lab for Crop Genetics and Breeding of Ministry of Agriculture, Beijing 100081, China
    Yi Chuan Xue Bao 32:197-202. 2005
    ..3 line). It is the first new soybean germplasm with null Lox1.2...
  59. ncbi Phosphatase and dehydrogenase activities in anodic chamber of single chamber microbial fuel cell (MFC) at variable substrate loading conditions
    M Venkateswar Reddy
    Bioengineering and Environmental Centre, Indian Institute of Chemical Technology, Hyderabad, India
    Bioelectrochemistry 77:125-32. 2010
    ..911kg COD/m(3)-day. Increase in OLR showed improvement in substrate degradation [OLR1, 56.32% (0.11kg COD/m(3)-day); OLR2, 56.42% (0.26kg COD/m(3)-day); OLR3, 59.53% (0.54kg COD/m(3)-day); OLR4, 64...
  60. ncbi Molecular sequence variations of the lipoxygenase-2 gene in soybean
    Jin Hee Shin
    Department of Plant Science and Research Institute for Agriculture and Life Sciences, Seoul National University, San 56 1, Sillim dong, Gwanak Gu, Seoul, 151 921, The Republic of Korea
    Theor Appl Genet 124:613-22. 2012
    Soybean lipoxygenase genes comprise a multi-gene family, with the seed lipoxygenase isozymes LOX1, LOX2, and LOX3 present in soybean seeds...
  61. ncbi Changes in oxylipin synthesis after Phytophthora infestans infection of potato leaves do not correlate with resistance
    Marie Laure Fauconnier
    Plant Biology Unit, Gembloux Agricultural University, Passage des Déportés 2, 5030 Gembloux, Belgium
    Plant Physiol Biochem 46:823-31. 2008
    ..A Northern blot preliminary study revealed that lipoxygenase (lox1 and lox3) and divinyl ether synthase genes were clearly up-regulated 96h after leaf inoculation with P. infestans...
  62. ncbi Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study
    Qi Chen
    Department of Human Genetics, and Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    J Lipid Res 52:801-7. 2011
    ..with serum lipid levels and nine candidate genes including APOE, APOH, APOA5, LPL, LRP1, HL, CETP, PON1, and OLR1. IgM anti-oxLDL levels were significantly higher in the >20% stenosis group than in the ? 20% stenosis group in ..
  63. ncbi Expression and localization of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in murine and human placentas
    Hiroo Satoh
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Histochem Cytochem 56:773-84. 2008
    ..These localization patterns of LOX-1 in murine and human placentas suggest the possible involvement of LOX-1 in high oxidative stress conditions of pregnancy...
  64. ncbi Soluble lectin-like oxidized low density lipoprotein receptor-1 in type 2 diabetes mellitus
    Kathryn C B Tan
    Department of Medicine, University of Hong Kong, Hong Kong, China
    J Lipid Res 49:1438-44. 2008
    ..sLOX-1 level is increased in type 2 diabetes. Both glucose and AGEs are important determinants of LOX-1 expression, and lowering glucose and AGEs leads to a reduction in sLOX-1...
  65. ncbi Anaerobic co-digestion of poultry blood with OFMSW: FTIR and TG-DTG study of process stabilization
    M J Cuetos
    Institute of Natural Resources IRENA, Avda de Portugal 41, University of Leon, 24071 Leon, Spain
    Environ Technol 30:571-82. 2009
    ..mesophilic anaerobic digester was studied with a hydraulic retention time (HRT) of 36 days and an organic loading (OLR1) of 1.5 kg VSS feed m(-3) d(-1)...
  66. ncbi Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells
    Yi Shi
    Cardiovascular Research, Institute of Physiology, University of Zurich, Zurich, Switzerland
    Arterioscler Thromb Vasc Biol 31:2090-7. 2011
    ..The present study was designed to elucidate the proatherogenic mechanisms by which p66(Shc) mediates oxidized low-density lipoprotein (oxLDL) uptake by the endothelium, a critical step in plaque formation...
  67. ncbi LOX-1: a critical player in the genesis and progression of myocardial ischemia
    Jingjun Lu
    Department of Emergency Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China
    Cardiovasc Drugs Ther 25:431-40. 2011
    ..Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, is a scavenger receptor that plays a fundamental role in the genesis and progression of atherosclerosis and ..
  68. ncbi Effect of exposure of human monocyte-derived macrophages to high, versus normal, glucose on subsequent lipid accumulation from glycated and acetylated low-density lipoproteins
    Fatemeh Moheimani
    Free Radical Group, The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW 2042, Australia
    Exp Diabetes Res 2011:851280. 2011
    ..High glucose elevated LOX1 mRNA, but decreased SR-AI, SR-BI, LDLR, and CD36 mRNA. SR-BI and CD36 protein levels were decreased...
  69. ncbi Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies
    Cynthia Palmieri-Thiers
    Université de Corse, CNRS UMR6134 SPE, Laboratoire de Biochimie et Biologie Moléculaire Végétales, campus Grimaldi, BP52, 20250 Corte, France
    Arch Biochem Biophys 509:82-9. 2011
    ..Recently, we isolated a cDNA encoding a LOX, named olive LOX1, from olive fruit of which the deduced amino acid sequence shows more than 50% identity with plant LOXs...
  70. ncbi Oxidised LDL internalisation by the LOX-1 scavenger receptor is dependent on a novel cytoplasmic motif and is regulated by dynamin-2
    Jane E Murphy
    Endothelial Cell Biology Unit, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK
    J Cell Sci 121:2136-47. 2008
    ..Taken together, these findings indicate that LOX-1 is internalised by a clathrin-independent and dynamin-2-dependent pathway and is thus likely to mediate OxLDL trafficking in vascular tissues...
  71. ncbi Serum sLOX-1 levels are associated with the presence and severity of angiographic coronary artery disease in patients with metabolic syndrome
    Bo Li
    Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, 1 Xinsi Road, Xian, Shanxi, P R China
    Clin Invest Med 33:E398-404. 2010
    ..We sought to assess whether serum sLOX-1 levels are correlated with the presence and severity of CAD in patients with metabolic syndrome (MetS) undergoing coronary angiography...
  72. ncbi Effect of polymorphisms in the FASN, OLR1, PPARGC1A, PRL and STAT5A genes on bovine milk-fat composition
    A Schennink
    Animal Breeding and Genomics Centre, Wageningen University, PO Box 338, 6700 AH Wageningen, The Netherlands
    Anim Genet 40:909-16. 2009
    ..in the ATP-binding cassette G2 (ABCG2), fatty acid synthase (FASN), oxidized low-density lipoprotein receptor 1 (OLR1), peroxysome proliferator-activated receptor-gamma coactivator-1alpha (PPARGC1A), prolactin (PRL) and signal ..
  73. ncbi Granulosa cell subtypes respond by autophagy or cell death to oxLDL-dependent activation of the oxidized lipoprotein receptor 1 and toll-like 4 receptor
    Heike Serke
    Institute of Anatomy, University of Leipzig, Leipzig, Germany
    Autophagy 5:991-1003. 2009
    ..has been observed in granulosa cell cultures via the oxLDL-dependent activation of lectin-like oxidized low density lipoprotein receptor 1 (LOX-1)...
  74. ncbi Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive
    María N Padilla
    Instituto de la Grasa, Avda Padre Garcia Tejero 4, 41012 Seville, Spain
    Phytochemistry 74:58-68. 2012
    ..Picual). The deduced amino acid sequence displayed significant similarity to known plant LOX1 sequences. Genomic Southern blot analysis suggests that only one copy of Oep2LOX1 is present in the olive genome...
  75. ncbi Coordinated transcriptional regulation of the divinyl ether biosynthetic genes in tobacco by signal molecules related to defense
    Alessandro Fammartino
    University of Turin, DiVaPRA Plant Pathology, Via L da Vinci 44, I 10095 Grugliasco TO, Italy
    Plant Physiol Biochem 48:225-31. 2010
    ..In this work, the regulation of NtLOX1 and NtDES1 expression by signal molecules was investigated in LOX1 promoter-reporter transgenic plants and by RT-qPCR...
  76. ncbi ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production
    Mark D Mattaliano
    Biological Technologies, Wyeth Research, Cambridge, MA 02140, USA
    Am J Physiol Cell Physiol 298:C1180-7. 2010
    ..In summary, a functional proteomics approach has enabled us to identify novel LOX-1 interactors that potentially contribute to the cellular and signaling functions of LOX-1...
  77. ncbi Increased lectin-like oxidized low-density lipoprotein receptor-1 expression in the maternal vasculature of women with preeclampsia: role for peroxynitrite
    Sowndramalingam Sankaralingam
    Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 53:270-7. 2009
    ....
  78. ncbi [Relationship between the expressions of lectin-like oxidized low-density lipoprotein receptor-1 and apoptosis associated genes in placenta tissues and the pathogenesis of preeclampsia]
    Tao Meng
    Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110003, China
    Zhonghua Fu Chan Ke Za Zhi 43:405-9. 2008
    ..To explore the expressions of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and apoptosis related genes caspase-3, Bax and bcl-2 in placenta, and their associations with the pathogenesis of preeclampsia...
  79. ncbi Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers
    Chiara Ferrandi
    Merck Serono Research RBM S p A, I 10010, Turin, Italy
    Mult Scler 17:43-56. 2011
    ..Autoimmune activation and deregulated apoptosis of T lymphocytes are involved in multiple sclerosis (MS). c-Jun N-terminal kinase (JNK) plays a role in T-cell survival and apoptosis...
  80. ncbi Surface plasmon resonance study on functional significance of clustered organization of lectin-like oxidized LDL receptor (LOX-1)
    Izuru Ohki
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0198, Japan
    Biochim Biophys Acta 1814:345-54. 2011
    ..In combination with the analyses on the loss-of-binding mutant W150A, we concluded that the clustered organization of the properly formed homodimeric CTLD is essential for the strong binding of LOX-1 to OxLDL...
  81. ncbi Glycoxidized LDL increases lectin-like oxidized low density lipoprotein receptor-1 in diabetes mellitus
    Sammy W M Shiu
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Atherosclerosis 203:522-7. 2009
    ....
  82. ncbi Modulation of placental protein expression of OLR1: implication in pregnancy-related disorders or pathologies
    M Ethier-Chiasson
    Laboratoire de Physiologie Materno Foetale, Departement des Sciences Biologiques, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Reproduction 136:491-502. 2008
    The lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (OLR1) is a newly described receptor for oxidatively modified LDL. The human pregnancy is associated with hyperlipidemia and oxidative stress...
  83. ncbi [Expression of lectin-liked oxidized low density lipoprotein receptor-1 and apoptosis associated genes in placenta and the relationship thereof with morbility of early-onset preeclampsia]
    Tao Meng
    Department of Obstetrics, First Hospital of China Medical University, Shenyang 110001, China
    Zhonghua Yi Xue Za Zhi 88:2633-5. 2008
    ....
  84. ncbi LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells
    Koichi Sugimoto
    First Department of Internal Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Cardiovasc Res 84:127-36. 2009
    ..Membrane type 1 matrix metalloproteinase (MT1-MMP) has been shown to be involved in atherogenesis. This study was conducted to investigate the role of the LOX-1-MT1-MMP axis in RhoA and Rac1 activation in response to ox-LDL in ECs...
  85. ncbi Molecular characterization and temporal expression analyses indicate that the MIC (Meloidogyne Induced Cotton) gene family represents a novel group of root-specific defense-related genes in upland cotton (Gossypium hirsutum L.)
    Martin J Wubben
    USDA ARS, Crop Science Research Laboratory, Genetics and Precision Agriculture Research Unit, MS 39762, USA
    Planta 228:111-23. 2008
    ..A time-course analysis of defense gene expression (PR10, ERF5, CDNS, LOX1, POD4, POD8) in resistant and susceptible cotton roots showed that RKN infection specifically elicits the induction ..
  86. ncbi Population differences in allele frequencies at the OLR1 locus may suggest geographic disparities in cardiovascular risk events
    Irene M Predazzi
    Department of Biopathology and Diagnostic Imaging, Section of Medical Genetics, School of Medicine, Tor Vergata University, Via Montpellier 1, Rome, Italy
    Ann Hum Biol 37:136-48. 2010
    ..The oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1) gene is the main receptor of ox-LDL...
  87. ncbi LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells
    Jane E Murphy
    Endothelial Cell Biology Unit, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Biochem J 393:107-15. 2006
    ..The LOX-1 membrane protein is thus a Ca2+-dependent phospholipid receptor, revealing novel recognition of phospholipids by mammalian lectins...
  88. ncbi Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor
    X Shi
    National Food Research Institute, Tsukuba, Ibaraki 305 8642, Japan
    J Cell Sci 114:1273-82. 2001
    ....
  89. ncbi Essential role of cytoplasmic sequences for cell-surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1)
    Mingyi Chen
    Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    J Mol Cell Cardiol 39:553-61. 2005
    ..Collectively, these results indicate that the N-terminal cytoplasmic domain of LOX-1 determines the correct expression of the lectin domain on the cell-surface...
  90. ncbi No association between polymorphisms in the lectin-like oxidised low density lipoprotein receptor (ORL1) gene on chromosome 12 and Alzheimer's disease in a UK cohort
    Antonia Pritchard
    Molecular Psychiatry Department, Division of Neuroscience, Queen Elizabeth Psychiatric Hospital, University of Birmingham, Birmingham B15 2QZ, UK
    Neurosci Lett 366:126-9. 2004
    ..investigating the +1071 and +1073 polymorphisms in the lectin-like oxidised low density lipoprotein receptor (OLR1) gene with AD, a gene that lies within the area of chromosome 12 linkage...
  91. ncbi Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12
    Erin Luedecking-Zimmer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Hum Genet 111:443-51. 2002
    ..to the A2M gene and because it is abundantly expressed in the brain, we reasoned that the oxidized LDL-receptor 1 (OLR1) gene could be a candidate gene for AD...
  92. ncbi The lectin-like oxidized low-density lipoprotein receptor and its role in atherosclerosis
    Mehmet Cilingiroglu
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Atheroscler Rep 7:103-7. 2005
    ..LOX-1 is inducible and regulated by multiple factors known to underlie atherogenesis. Further understanding of this receptor may lead to potential molecular targets for prevention and treatment of atherosclerosis...
  93. ncbi NF-kappa B activation in endothelial cells treated with oxidized high-density lipoprotein
    Toshiyuki Matsunaga
    Department of Biochemistry, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 303:313-9. 2003
    ..Taking all of the above findings together, ox-HDL activates NF-kappa B via binding to LOX-1 on the cell surface, followed by enhancement of intracellular ROS production in endothelial cells...
  94. ncbi A new 9-lipoxygenase cDNA from developing rice seeds
    Kouichi Mizuno
    Institute of Agricultural and Forest Engineering, University of Tsukuba, Tsukuba Science City, Ibaraki 305 8572, Japan
    Plant Cell Physiol 44:1168-75. 2003
    We isolated a novel C9 position specific lipoxygenase (r9-LOX1) cDNA from developing rice seeds. The enzymatic features of r9-LOX1 resembled those of rice LOX-L3 known to be contained in rice germ and to have C9-specific LOX activity...
  95. ncbi [Effects of LOX-1 on expression of adhesion molecules induced by ox-LDL in HUVECs]
    Hui Lian Zhu
    School of Public Health, Sun Yat Sen University, Guangzhou 510080, China
    Zhonghua Xin Xue Guan Bing Za Zhi 33:743-7. 2005
    ..To investigate the effects of oxidized low-density lipoprotein receptor 1 (LOX-1) on secretion of adhesive molecules mediated by ox-LDL in human umbilical endothelial cells (HUVECs)...
  96. ncbi Lysophosphatidylcholine upregulates LOX-1, chemokine receptors, and activation-related transcription factors in human T-cell line Jurkat
    Yuko Hara
    Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    J Thromb Thrombolysis 26:113-8. 2008
    ..Further, it suggested that lysoPC and CD4 T cells accumulating in atherosclerotic lesions contribute to the development of arteriosclerosis...
  97. ncbi Additional support for an association between OLR1 and milk fat traits in cattle
    H Khatib
    Department of Dairy Science, University of Wisconsin, Madison, WI 53706, USA
    Anim Genet 38:308-10. 2007
    The bovine oxidized LDL receptor 1 (OLR1) was chosen as a candidate gene for association tests with milk composition traits. Genotyping of 773 Italian Brown Swiss for a SNP at position 8232 in OLR1 (NW_215807:g...
  98. ncbi The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile
    S Yamanaka
    Department of Pharmacology, Osaka City University Medical School, Osaka, 545 8585, Japan
    Genomics 54:191-9. 1998
    ..In the present study, we cloned and characterized the human LOX-1 gene (HGMW-approved symbol OLR1). The gene structure of LOX-1 resembles that of the natural killer cell receptors...
  99. ncbi An Arabidopsis thaliana lipoxygenase gene can be induced by pathogens, abscisic acid, and methyl jasmonate
    M A Melan
    Department of Biological Sciences, Wellesley College, Massachusetts 02181
    Plant Physiol 101:441-50. 1993
    ..DNA blot analysis indicated that Arabidopsis contains a single gene, LOX1, with appreciable homology to the cDNA clone...
  100. ncbi The centromeric part of the human NK gene complex: linkage of LOX-1 and LY49L with the CD94/NKG2 region
    C Bull
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Genes Immun 1:280-7. 2000
    ..In addition, in the course of these studies several EST sequences were localized in the region, one immediately upstream of the LY49L gene...
  101. ncbi Oxidized-LDL through LOX-1 increases the expression of angiotensin converting enzyme in human coronary artery endothelial cells
    Dayuan Li
    Department of Internal Medicine, University of Arkansas for Medical Sciences, Mail Slot 532, 4301 W Markham, Little Rock, AR 72205, USA
    Cardiovasc Res 57:238-43. 2003
    ..In addition, we studied the effect of the HMG CoA reductase inhibitor simvastatin on this interaction...

Research Grants18

  1. 15-LOX-15(S)-HETE axis and angiogenesis
    Gadiparthi N Rao; Fiscal Year: 2010
    The presence of two 15-lipoxygenases (15-LOXs), namely, 15-LOX1 and 15-LOX2, has been reported in humans...
  2. RECEPTOR FOR GP96 ON MACROPHAGES AND DENDRITIC CELLS
    Pramod Srivastava; Fiscal Year: 2007
    ..a) Definition of the hsp90/gp96/hsp70 domains involved in interaction with CD91, and if necessary, LOX1 ;(b) Definition of the CD91 domain(s) involved in interaction with hsp90 and gp96...
  3. EICOSANOIDS AND VASCULAR WALL REMODELING
    Gadiparthi N Rao; Fiscal Year: 2010
    ..Specific Aim 4: Overexpression of 15-LOX1/2 exacerbates injury-induced neointima formation via production of 15(S)-HETE and thereby in the enhancement of SMC ..
  4. DNA Diagnostics for Minimizing Metabolic Side-Effects of Antipsychotics
    GUALBERTO RUANO; Fiscal Year: 2007
    ..The products will enable DNA- guided medicine: the determination of which AAP is most suitable and the implementation of clinical safeguards, individualized to each patient, using his/her personal genome. ..
  5. Physiogenomic Arrays for Clinical Neuropsychiatry
    GUALBERTO RUANO; Fiscal Year: 2006
    ..The program will develop NeuroPsych Gene Array products as a new tool for systems understanding of neuropsychiatric and neurodegenerative diseases leading to early diagnosis and personalized therapy. ..
  6. OXIDANT STRESS AND ENDOTHELIAL CELL METABOLISM
    LORRAINE SORDILLO; Fiscal Year: 2001
    ..Results form these studies will provide the molecular basis of how Se deficiency can modify resistance to metabolic vascular disorders. ..