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Genomes and Genes
| NID2SummaryGene Symbol: NID2 Description: nidogen 2 (osteonidogen) Alias: NID-2, nidogen-2, osteonidogen Species: human Top Publications
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Publications
Nidogen-2: a new serum biomarker for ovarian cancerCynthia Kuk
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
Clin Biochem 43:355-61. 2010..New ovarian cancer biomarkers suitable for early disease diagnosis, prognosis or monitoring could improve patient management and outcomes...- Nidogen-2: a new basement membrane protein with diverse binding propertiesE Kohfeldt
Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
J Mol Biol 282:99-109. 1998..Both nidogens were cell-adhesive for a restricted number of cell lines, with nidogen-2 having a higher activity. Together, these data suggest that nidogen-2 can compensate for some but not all functional activities ascribed to nidogen-1... - The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparinHongmin Tu
Collagen Research Unit, Biocenter and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Aapistie 7, FIN 90220 Oulu, Finland
J Biol Chem 277:23092-9. 2002.... - Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic miceNicolai Miosge
Department of Histology, Georg August Universitat Gottingen, D 37075, Gottingen, Germany
Matrix Biol 21:611-21. 2002..The data support the nidogen-2 compensation hypothesis to explain the limited phenotype observed following elimination of the nidogen-1 gene... - Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancerLinda Ulazzi
Dipartimento di Medicina Sperimentale e Diagnostica e Centro Interdipartimentale per la Ricerca sul Cancro, Universita di Ferrara, Ferrara, Italy
Mol Cancer 6:17. 2007Nidogens are highly conserved proteins of basement membranes. Two nidogen proteins, nidogen 1 and nidogen 2, are known in mammals. - Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic developmentN Miosge
Zentrum Anatomie, Abteilung Histologie, Goettingen, Germany
Histochem J 33:523-30. 2001..These two proteins might well be able to fulfil identical functions during human organogenesis... - Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecanM Hopf
Max Planck Institut fur Biochemie, Martinsried, D 82152, Germany
J Mol Biol 311:529-41. 2001..This implicates a complex cluster of heterotypic interaction sites apparently important for the supramolecular organization of perlecan in tissues... - Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteinsT Sasaki
Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152, Martinsried, Germany
FEBS Lett 460:280-4. 1999..The colocalization of these proteins emphasizes the potential for in vivo interactions... - Identification of differentially expressed genes in individual bovine preimplantation embryos produced by nuclear transfer: improper reprogramming of genes required for developmentMartha Pfister-Genskow
Infigen, Inc, DeForest, Wisconsin 53532, USA
Biol Reprod 72:546-55. 2005..associated with stress responses (heat shock protein 27) along with major histocompatibility complex class I, nidogen 2, a putative transport protein, heterogeneous nuclear ribonuclear protein K, mitochondrial 16S rRNA, and ES1 (a .. - Impaired wound healing in mice lacking the basement membrane protein nidogen 1Anke Baranowsky
Department of Dermatology, University Hospital Cologne, Cologne, Germany
Matrix Biol 29:15-21. 2010..However, neurological deficits in nidogen 1 null mice, not seen in the absence of nidogen 2, also suggest isoform specific functions... - SgrA, a nidogen-binding LPXTG surface adhesin implicated in biofilm formation, and EcbA, a collagen binding MSCRAMM, are two novel adhesins of hospital-acquired Enterococcus faeciumAntoni P A Hendrickx
Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, Rm G04 614, 3584 CX Utrecht, The Netherlands
Infect Immun 77:5097-106. 2009..identify a surface adhesin among bacteria (SgrA) that binds to the extracellular matrix molecules nidogen 1 and nidogen 2, which are constituents of the basal lamina. EcbA is a novel E... - Identification and validation of the methylated TWIST1 and NID2 genes through real-time methylation-specific polymerase chain reaction assays for the noninvasive detection of primary bladder cancer in urine samplesIsabelle Renard
OncoMethylome Sciences SA, Liege, Belgium
Eur Urol 58:96-104. 2010..Accumulating evidence suggests that DNA methylation markers could serve as sensitive and specific cancer biomarkers... - The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expressionFrank A Simmen
Department of Physiology and Biophysics, and the Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
Reprod Biol Endocrinol 6:41. 2008..This cell line provides a unique model for identifying KLF9 downstream gene targets and signaling pathways... - Isolation and characterization of virulent bacteriophages against Escherichia coli serogroups O1, O2, and O78N Jamalludeen
Department of Food Science, University of Guelph, Guelph, Ontario N1G 3W1, Canada
Poult Sci 88:1694-702. 2009..Seven phages were isolated; only 2 of them, EC-Nid1 and EC-Nid2, were selected for further characterization... - A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junctionMichael A Fox
Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
Neural Dev 3:24. 2008..In each case, the synaptic isoform plays key roles in organizing the neuromuscular junction. Here, we analyze the fourth family, composed of nidogen-1 and -2... - Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survivalVesela P Kovacheva
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
FASEB J 23:1054-63. 2009..choline-supplemented rats overexpressed genes that confer favorable prognosis in human cancers (Klf6, Klf9, Nid2, Ntn4, Per1, and Txnip) and underexpressed those associated with aggressive disease (Bcar3, Cldn12, Csf1, Jag1, .. - Alterations of extracellular matrix components and proteinases in human corneal buttons with INTACS for post-laser in situ keratomileusis keratectasia and keratoconusEzra Maguen
Ophthalmology Research, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Cornea 27:565-73. 2008..To perform an immunohistochemical evaluation of corneas with INTACS for post-laser in situ keratomileusis (LASIK) keratectasia and keratoconus, obtained after corneal transplantation... - Basement membrane protein nidogen-1 shapes hippocampal synaptic plasticity and excitabilityAnju Vasudevan
Center for Biochemistry and Center for Molecular Medicine Cologne, University of Cologne, Joseph Stelzmann Str 52, 50931 Koln, Germany
Hippocampus 20:608-20. 2010..Using nidogen-1 knockout mice, with or without additional heterozygous nidogen-2 knockout (NID1(-/-)/NID2(+/+) or NID1(-/-)/NID2(+/-)), we demonstrate that nidogen is essential for normal neuronal network excitability and .. - Lack of nidogen-2 increases blood pressure, glomerular and tubulointerstitial damage in DOCA-salt hypertensionK Amann
University of Erlangen Nuernberg, University of Luebeck, Erlangen, Germany
Eur J Clin Invest 39:116-25. 2009..We tested the hypothesis that nidogen-2 mediated cell-matrix interactions are important to maintain glomerular integrity and structure in renal hyperperfusion and hypertension... - Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changesMehrnoosh Saghizadeh
Ophthalmology Research Laboratories, Cedars Sinai Medical Center, Los Angeles, CA, USA
Brain Res Bull 81:262-72. 2010..The data suggest that MMP-10 and CTSF may be responsible for abnormal marker patterns and impaired wound healing in diabetic corneas. Inhibition of these proteinases in diabetic corneas may alleviate diabetic keratopathy symptoms... - Decompression from saturation using oxygen: its effect on DCS and RNA in large swineNina Malkevich
Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
Aviat Space Environ Med 81:15-21. 2010..To evaluate any benefit of HBO during decompression, we used a 70-kg swine model of saturation and examined lung tissue by microarray analysis for evidence of RNA regulation... - Expression of extracellular matrix components is disrupted in the immature and adult estrogen receptor ?-null mouse ovaryAlexandra Zalewski
Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
PLoS ONE 7:e29937. 2012..Similarly, Nidogen 2, a highly conserved basement membrane glycoprotein, is elevated in ER?-null follicles at PND 13 into adulthood, .. - Clinical significance of decreased nidogen-2 expression in the tumor tissue and serum of patients with hepatocellular carcinomaZhi xiang Cheng
Department of Hepatobiliary Surgery, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
J Surg Oncol 105:71-80. 2012..However, the expression and function of nidogen-2 in hepatocellular carcinoma (HCC) remains unknown at present. In this study, we sought to investigate the potential role of nidogen-2 in HCC... - Gain and loss of extracellular molecules in sporadic inclusion body myositis and polymyositis--a proteomics-based studyKathrin Doppler
Department of Pathology and Neuropathology, Divison of Neuropathology, University Hospital of Tubingen, Tubingen, Germany
Brain Pathol 22:32-40. 2012..Similar to BM remodeling, the specific deposition of PRELP and biglycan may represent a mechanism to defend against immune attack. Loss of P component may affect the anchorage of the myofiber in the endomysium... - NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and salivaR Guerrero-Preston
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, Maryland 21231, USA
Cancer Prev Res (Phila) 4:1061-72. 2011..Promoter methylation of KIF1A (? = 0.64), HOXA9 (? = 0.60), NID2 (? = 0.60), and EDNRB (? = 0... - Differential gene expression profiling of aggressive and nonaggressive follicular carcinomasMichelle D Williams
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Hum Pathol 42:1213-20. 2011..CKS2), and 4 genes that distinguished aggressive follicular carcinomas from nonaggressive follicular carcinomas (NID2, TM7SF2, TRIM2, and GLTSCR2)... - Transcriptomic signature of trophoblast differentiation in a human embryonic stem cell modelMélanie Marchand
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, USA
Biol Reprod 84:1258-71. 2011..Some of them are hypothesized to be associated mainly with extracellular matrix remodeling (e.g., NID2) and cell migration and invasion (e.g., RAB25)... - SMOC1 is a tenascin-C interacting protein over-expressed in brain tumorsFlorence Brellier
Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
Matrix Biol 30:225-33. 2011..The present study thus identified SMOC1 as a new cancer-associated protein capable of interacting with tenascin-C in vitro... - Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chainSharada Mokkapati
Department of Dermatology, University Hospital of Cologne, 50937 Cologne, Germany
J Biol Chem 286:1911-8. 2011..Furthermore, although nidogen 1 deposition was strongly reduced, nidogen 2 appeared unchanged... - Comprehensive profiling of cartilage extracellular matrix formation and maturation using sequential extraction and label-free quantitative proteomicsRichard Wilson
Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Melbourne, Victoria 3052, Australia
Mol Cell Proteomics 9:1296-313. 2010..The extraction profile and matrix-associated immunostaining implicates protease nexin-1 in cartilage development in vitro and in vivo... - [Detection of bladder cancer in voided urine samples]A Thomas
Service d Urologie, CHU de Liege, Belgique
Rev Med Liege 64:9-14. 2009..recently publised in European Urology, have shown that the identification by MSP of 2 methylated genes, TWIST1 and NID2, in voided urine samples, is a sensitive (+/- 90%) and specific (+/- 93%) test for the detection of bladder cancer... - Mossbauer evidence for an exchange-coupled {[Fe4S4]1+ Nip1+} A-cluster in isolated alpha subunits of acetyl-coenzyme A synthase/carbon monoxide dehydrogenaseXiangshi Tan
Department of Chemistry and Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
J Am Chem Soc 130:6712-3. 2008..Relative to the inactive {[Fe4S4]2+ Nip2+ Nid2+} state, the activated state appears to be 2-electrons more reduced, but the location of these electrons within the .. - Nidogen-1 and nidogen-2 in healthy human cartilage and in late-stage osteoarthritis cartilageJenny Kruegel
Georg August University, Goettingen, Germany
Arthritis Rheum 58:1422-32. 2008..To investigate the presence and function of nidogen-1 and nidogen-2 in healthy human cartilage and in late-stage osteoarthritis (OA) cartilage... - Basement membrane composition in the early mouse embryo day 7Nikolaus Gersdorff
Department of Prosthodontics, Georg August Universitat Gottingen, Gottingen, Germany
Dev Dyn 233:1140-8. 2005..In conclusion, laminin-1 might be the only laminin isoform in the early mouse embryo that, together with the other main BM components, nidogens, collagen type IV, and perlecan, is synthesized by all three germ layers... - Laminin gamma3 chain binds to nidogen and is located in murine basement membranesNikolaus Gersdorff
Department of Prosthodontics, University of Goettingen, D 37075 Goettingen, Germany
J Biol Chem 280:22146-53. 2005..Ultrastructural immunogold staining localized the gamma3 chain to basement membranes of these tissues... - DNA microarrays and likelihood ratio bioinformatic methods: discovery of human melanocyte biomarkersThomas P Dooley
IntegriDerm Inc, Birmingham, AL 35211 6908, USA
Pigment Cell Res 16:245-53. 2003..Some of the melanocytic biomarkers identified here may be useful in molecular diagnostics, as potential molecular targets for drug discovery, and for understanding the biochemistry of melanocytic cells... - Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogensKatriina Salmivirta
Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
Exp Cell Res 279:188-201. 2002..These findings revealed extensive coregulation of nidogen-1 and -2 expression and much more complementary functions of the two nidogens than previously recognized... - Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is not essential for basement membrane formation in miceJurgen Schymeinsky
Department of Protein Chemistry, Max Planck Institute for Biochemistry, D 82152 Martinsried, Germany
Mol Cell Biol 22:6820-30. 2002..Nidogen-2 deficiency does not lead to hemorrhages in mice as one may have expected. Our results show that nidogen-2 is not essential for basement membrane formation or maintenance... - The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchorEva Bengtsson
Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, SE 221 84 Lund, Sweden
J Biol Chem 277:15061-8. 2002..Based on the location of PRELP and its interaction with perlecan heparan sulfate chains and collagen, we propose a function of PRELP as a molecule anchoring basement membranes to the underlying connective tissue... - Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteinsT Sasaki
Max Planck Institut fur Biochemie, Martinsried, D 82152, Germany
J Mol Biol 314:751-63. 2001..Immunological studies showed a similar partial processing in cell culture and tissues and the persistence of the released fragment in tissues. This indicated that both N-terminal regions of the gamma2 chain may have a function in vivo... - The absence of nidogen 1 does not affect murine basement membrane formationM Murshed
Department of Dermatology, Medical Faculty, University of Cologne, Germany
Mol Cell Biol 20:7007-12. 2000..b>Nidogen 2 staining is increased in certain basement membranes, where it is normally only found in scant amounts... - LDL receptor-related protein as a component of the midkine receptorH Muramatsu
Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
Biochem Biophys Res Commun 270:936-41. 2000..Brushin/megalin, which is also a high molecular weight protein belonging to the LDL receptor family, bound to MK less strongly than LRP. These findings suggest that LRP is a component of the receptor complex for MK... - Ultrastructural colocalization of nidogen-1 and nidogen-2 with laminin-1 in murine kidney basement membranesN Miosge
Zentrum Anatomie, Abteilung Histologie, Goettingen, Germany
Histochem Cell Biol 113:115-24. 2000..The results indicate that nidogen-1 and nidogen-2 could well substitute for one another in some of their biological activities in kidney, for example, stabilizing basement membrane networks in vivo... - Expression of nidogens in rat uterus and embryo during decidualization and implantationHakan Oner
Department of Histology and Embryology, Faculty of Veterinary Medicine, Akdeniz University, 15100 Burdur, Turkey
J Morphol 267:822-30. 2006..These results indicate that nidogen-1 and nidogen-2 could play important roles during embryogenesis, decidualization, and implantation in the endometrium of rat uterus... - Hematopoietic cells are a source of nidogen-1 and nidogen-2 during mouse liver developmentLaurice T Tomte
Department of Histology, University of Goettingen, Goettingen, Germany
J Histochem Cytochem 54:593-604. 2006..We suggest that nidogens may, to some extent, take part in the regulation of hepatic hematopoiesis... - IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virusJuan Tan
Key Laboratory of Molecular Microbiology and Biotechnology Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China
J Virol 82:4275-83. 2008..The interaction involves NID2 (IFP35/Nmi homology domain) of IFP35 and the central domain of BTas... - Compositional differences between infant and adult human corneal basement membranesAndrea Kabosova
Ophthalmology Research Laboratories, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Invest Ophthalmol Vis Sci 48:4989-99. 2007..Adult human corneal epithelial basement membrane (EBM) and Descemet's membrane (DM) components exhibit heterogeneous distribution. The purpose of the study was to identify changes of these components during postnatal corneal development... - Framingham Heart Study genome-wide association: results for pulmonary function measuresJemma B Wilk
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
BMC Med Genet 8:S8. 2007..We conducted genome-wide association (GWA) analyses (Affymetrix 100K SNP GeneChip) for measures of lung function in the Framingham Heart Study... - Immunohistochemical evaluation of two corneal buttons with post-LASIK keratectasiaEzra Maguen
Ophthalmology Research, Cedars Sinai Medical Center, Los Angeles, CA, USA
Cornea 26:983-91. 2007..To examine immunohistochemically 2 human corneal buttons after corneal transplantation for post-laser in situ keratomileusis (LASIK) keratectasia... - The autoantigen in anti-p200 pemphigoid is synthesized by keratinocytes and fibroblasts and is distinct from nidogen-2Silke C Hofmann
Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
J Invest Dermatol 128:87-95. 2008.... - The absence of one or both nidogens does not alter basement membrane composition in adult murine kidneyN Gersdorff
Department of Prosthodontics, Georg August University Goettingen, Goettingen, Germany
Histol Histopathol 22:1077-84. 2007..The results indicate that the lack of nidogen-1, nidogen-2, or both nidogens, plays no crucial role in the occurrence and localization of laminin-111, collagen type IV, and perlecan in murine tubular renal basement membranes... - A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localizationNaoyuki Kobayashi
Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
J Biol Chem 282:11805-16. 2007..Immunoelectron microscopy localized fibulin-4 and -5 to fibrillin microfibrils at distinct locations. Our studies suggest there are unique and redundant functions shared by these structurally related proteins... - Differential expression of entactin-1/nidogen-1 and entactin-2/nidogen-2 in myogenic differentiationRicarda Neu
Institute of Physiology Charité, University Medicine Berlin, Arnimallee 22, 14195 Berlin, Germany
Differentiation 74:573-82. 2006..These data suggest important and distinct functions of entactin-1 and -2 in myogenic differentiation... - Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic cocultureRoswitha Nischt
Department of Dermatology, University of Cologne, Cologne, Germany
J Invest Dermatol 127:545-54. 2007.... - Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophilsShijun Wang
Cardiovascular Medicine Unit, National Heart and Lung Institute, Division of Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London W12 ONN, England, UK
J Exp Med 203:1519-32. 2006.... - Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteinsJ F Talts
Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
EMBO J 18:863-70. 1999..This demonstrated similar binding repertoires for the LG modules of three basement membrane proteins involved in cell-matrix interactions and supramolecular assembly...
Research Grants
- SULFOTRANSFERASE EXPRESSION IN EPITHELIA AND CARCINOMASTHOMAS DOOLEY; Fiscal Year: 2001..The anticipated results will provide valuable insights into the roles of the human ST gene superfamily in the metabolism and bioavailability of drugs and endogenous compounds in human epithelia and cancers. ..
- Dietary Factors in Colon Cancer PreventionFRANK ALBERT SIMMEN; Fiscal Year: 2010....
- Dietary Factors in Colon Cancer PreventionFRANK ALBERT SIMMEN; Fiscal Year: 2011..These studies have strong translational significance for improving the health and quality of life of the overweight/obese population at risk for or afflicted with colo-rectal cancer. ..