neurofilament M

Summary

Gene Symbol: neurofilament M
Description: neurofilament, medium polypeptide
Alias: NEF3, NF-M, NFM, 160 kDa neurofilament protein, neurofilament 3, neurofilament medium polypeptide, neurofilament triplet M protein, neurofilament, medium polypeptide 150kDa, neurofilament-3 (150 kD medium)
Species: human

Top Publications

  1. ncbi Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits
    P H Tu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    J Cell Biol 129:1629-40. 1995
  2. ncbi Identification of six phosphorylation sites in the COOH-terminal tail region of the rat neurofilament protein M
    Z S Xu
    Department of Anatomy and Neurobiology and Biochemistry, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 267:4467-71. 1992
  3. ncbi Aberrant neuronal and mitochondrial proteins in hippocampus of transgenic mice overexpressing human Cu/Zn superoxide dismutase 1
    Joo Ho Shin
    Department of Pediatrics, University of Vienna, A 1090, Vienna, Austria
    Free Radic Biol Med 37:643-53. 2004
  4. ncbi High-performance liquid chromatographic determination of n-methylformamide, a biological index for occupational exposure to dimethylformamide
    G Tranfo
    Institute for Occupational Prevention and Safety, Department of Occupational Hygiene, Rome, Italy
    J Chromatogr A 847:19-24. 1999
  5. ncbi Chronic treatment with high doses of corticosterone decreases cytoskeletal proteins in the rat hippocampus
    Marina Cereseto
    Instituto de Investigaciones Farmacológicas ININFA, UBA CONICET, Junín 956 5to piso 1113, Buenos Aires, Argentina
    Eur J Neurosci 24:3354-64. 2006
  6. ncbi CpG island hypermethylation in human astrocytomas
    Xiwei Wu
    Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA
    Cancer Res 70:2718-27. 2010
  7. ncbi MHC haplotype involvement in avian resistance to an ectoparasite
    Jeb P Owen
    Department of Entomology, University of California, Riverside, CA, 92521, USA
    Immunogenetics 60:621-31. 2008
  8. ncbi Mice with the deleted neurofilament of low-molecular-weight (Nefl) gene: 1. Effects on regional brain metabolism
    M Dubois
    Faculte des Sciences, UPRES PSY CO EA 1780, Universite de Rouen, Mont Saint Aignan, France
    J Neurosci Res 80:741-50. 2005
  9. ncbi Isolation of multipotent stem cells from adult rat periodontal ligament by neurosphere-forming culture system
    Wanida Techawattanawisal
    Department of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Biochem Biophys Res Commun 357:917-23. 2007
  10. ncbi Effectiveness of a large-scale iron-fortified milk distribution program on anemia and iron deficiency in low-income young children in Mexico
    Juan A Rivera
    Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Publica, Avenida Universidad 655, Colonia Sta Ma Ahuacatitlán, CP 62508, Cuernavaca, Morelos, Mexico
    Am J Clin Nutr 91:431-9. 2010

Research Grants

  1. DYNAMICS OF THE NEURONAL CYTOSKELETON IN AGING BRAIN
    Ralph A Nixon; Fiscal Year: 2010
  2. DYNAMICS OF THE NEURONAL CYTOSKELETON IN AGING BRAIN
    Ralph Nixon; Fiscal Year: 2006
  3. FUSION PROTEINS IN THE MOLECULAR PATHOGENESIS OF APL
    Pier Paolo Pandolfi; Fiscal Year: 1999
  4. Neurofilaments, SOD1 and Motor Neuron Diseases
    Don Cleveland; Fiscal Year: 2007
  5. Organ lumen morphogenesis in C. elegans
    VERENA GOBEL; Fiscal Year: 2004
  6. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2007
  7. MT COBRE: EFFECT OF LEAD ON DEVELOPMENT OF AUDITORY TEMPORAL PROCESSING
    DIANA LURIE; Fiscal Year: 2006
  8. Differential Gene Expression in the Cochlear Nucleus
    David Friedland; Fiscal Year: 2007
  9. Genetic Control of Olfactory Bulb Size in Schizophrenia
    Lise Rioux; Fiscal Year: 2006
  10. Hippocampal Retinoid Pathway in Schizophrenia
    Lise Rioux; Fiscal Year: 2002

Scientific Experts

Detail Information

Publications103 found, 100 shown here

  1. ncbi Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits
    P H Tu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    J Cell Biol 129:1629-40. 1995
    ..system (CNS) and peripheral nervous system (PNS) neurons, are heteropolymers formed from the high (NFH), middle (NFM), and low (NFL) molecular weight NF subunits...
  2. ncbi Identification of six phosphorylation sites in the COOH-terminal tail region of the rat neurofilament protein M
    Z S Xu
    Department of Anatomy and Neurobiology and Biochemistry, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 267:4467-71. 1992
    ..The identification of these sites should aid in investigations of the function of the phosphorylation of this protein and provides criteria for identifying the relevant kinases...
  3. ncbi Aberrant neuronal and mitochondrial proteins in hippocampus of transgenic mice overexpressing human Cu/Zn superoxide dismutase 1
    Joo Ho Shin
    Department of Pediatrics, University of Vienna, A 1090, Vienna, Austria
    Free Radic Biol Med 37:643-53. 2004
    ..factor, synaptosomal-associated protein 25, dynamin-1, neurofilament triplet L protein, neurofilament triplet M protein, neuronal tropomodulin, and neuronal protein 25 were significantly decreased in Tg-SOD1...
  4. ncbi High-performance liquid chromatographic determination of n-methylformamide, a biological index for occupational exposure to dimethylformamide
    G Tranfo
    Institute for Occupational Prevention and Safety, Department of Occupational Hygiene, Rome, Italy
    J Chromatogr A 847:19-24. 1999
    ..HMMF and NFM can be measured independently using HPLC analysis...
  5. ncbi Chronic treatment with high doses of corticosterone decreases cytoskeletal proteins in the rat hippocampus
    Marina Cereseto
    Instituto de Investigaciones Farmacológicas ININFA, UBA CONICET, Junín 956 5to piso 1113, Buenos Aires, Argentina
    Eur J Neurosci 24:3354-64. 2006
    ..Twenty-one days later, light, medium and heavy subunits of intermediate neurofilaments (NFL, NFM and NFH) and the microtubule-associated protein 2 (MAP2) were quantified by immunohistochemistry in Ammon's horn ..
  6. ncbi CpG island hypermethylation in human astrocytomas
    Xiwei Wu
    Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA
    Cancer Res 70:2718-27. 2010
    ....
  7. ncbi MHC haplotype involvement in avian resistance to an ectoparasite
    Jeb P Owen
    Department of Entomology, University of California, Riverside, CA, 92521, USA
    Immunogenetics 60:621-31. 2008
    ..only at the MHC, were comparatively infested with a cosmopolitan ectoparasite of birds-northern fowl mite (NFM)-which is also a serious pest species of poultry...
  8. ncbi Mice with the deleted neurofilament of low-molecular-weight (Nefl) gene: 1. Effects on regional brain metabolism
    M Dubois
    Faculte des Sciences, UPRES PSY CO EA 1780, Universite de Rouen, Mont Saint Aignan, France
    J Neurosci Res 80:741-50. 2005
    Neuronal intermediate filaments consist of the NFL subunit linked with NFM and NFH, and their alterations have been proposed as a pathogenesic cause in motor neuron diseases...
  9. ncbi Isolation of multipotent stem cells from adult rat periodontal ligament by neurosphere-forming culture system
    Wanida Techawattanawisal
    Department of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Biochem Biophys Res Commun 357:917-23. 2007
    ..PDL-derived spheres differentiated into multinucleated myotubes, NFM-positive neuron-like cells, GFAP-positive astrocyte-like cells and CNPase-positive oligodendrocyte-like cells...
  10. ncbi Effectiveness of a large-scale iron-fortified milk distribution program on anemia and iron deficiency in low-income young children in Mexico
    Juan A Rivera
    Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Publica, Avenida Universidad 655, Colonia Sta Ma Ahuacatitlán, CP 62508, Cuernavaca, Morelos, Mexico
    Am J Clin Nutr 91:431-9. 2010
    ..Anemia during infancy impairs neurodevelopment. Little information has been published about the effectiveness of large-scale programs on anemia and iron-deficiency prevention...
  11. ncbi High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal
    Takafumi Wataya
    Institute of Pathology and Departments of Physiology and Biophysics, and Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 277:4644-8. 2002
    ..are only detected in neurofilament heavy subunit (NFH) and, to a lesser extent, neurofilament medium subunit (NFM), both lysine-rich proteins, consistent with the adducts being limited to lysine residues...
  12. ncbi [Transcription of cytoskeleton protein genes in differentiation of neurons from mouse embryonic stem cells induced by small molecules]
    Min Hua Xu
    Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou 310058, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 38:242-8. 2009
    ....
  13. ncbi Neurofilament localization and phosphorylation in the developing inner ear of the rat
    Edith L G M Tonnaer
    Radboud University Nijmegen Medical Center, Department of Otorhinolaryngology, Head and Neck Surgery, Donders Institute for Brain, Cognition and Behaviour, Center for Neuroscience, Philips van Leydenlaan 15, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Hear Res 267:27-35. 2010
    ..and 30 days after birth, using antibodies against phosphorylated as well as non-phosphorylated light (NFL), medium (NFM) and heavy (NFH) neurofilament subunits...
  14. ncbi The polypeptide composition of moving and stationary neurofilaments in cultured sympathetic neurons
    Yanping Yan
    Department of Neuroscience, Center for Molecular Neurobiology, The Ohio State University, Columbus, Ohio 43210, USA
    Cell Motil Cytoskeleton 64:299-309. 2007
    ..All neurofilaments, both moving and stationary, contained NFL, NFM, peripherin and alpha-internexin along>85% of their length...
  15. ncbi Detection of thromboxane A(2) receptor mRNA in rabbit nodose ganglion neurons
    Michael J Wacker
    Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA
    Neurosci Lett 386:121-6. 2005
    ..then designed based on this sequence and used in conjunction with a neuronal marker, medium weight neurofilament (NFM), in multiplex RT-PCR reactions...
  16. ncbi Surface engineering of electrospun polyethylene terephthalate (PET) nanofibers towards development of a new material for blood vessel engineering
    Zuwei Ma
    Nanoscience and Nanotechnology Initiative, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore
    Biomaterials 26:2527-36. 2005
    Non-woven polyethylene terephthalate nanofiber mats (PET NFM) were prepared by electrospinning technology and were surface modified to mimic the fibrous proteins in native extracellular matrix towards constructing a biocompatible surface ..
  17. ncbi Artificial intelligence and bladder cancer arrays
    P J Wild
    Institute of Surgical Pathology, University Hospital Zurich
    Verh Dtsch Ges Pathol 91:308-19. 2007
    ..Here, we describe a new method of microarray analysis using neurofuzzy modeling (NFM), a form of artificial intelligence, and integrate it with artificial neural networks (ANN) to investigate non-..
  18. ncbi Axonal transport and cytoskeletal changes in the laminar regions after elevated intraocular pressure
    Chandrakumar Balaratnasingam
    Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Australia
    Invest Ophthalmol Vis Sci 48:3632-44. 2007
    ....
  19. ncbi Cell body response to injury in motoneurons and primary sensory neurons of a mutant mouse, Ola (Wld), in which Wallerian degeneration is delayed
    M A Bisby
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    J Comp Neurol 359:653-62. 1995
    ..and DRG neurons was similar in both strains of mice, as was the initial decrease in medium-weight neurofilament (NFM) mRNA in facial motoneurons, and the increase in JUN immunoreactivity in both types of neurons...
  20. ncbi The application of artificial intelligence to microarray data: identification of a novel gene signature to identify bladder cancer progression
    James W F Catto
    Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    Eur Urol 57:398-406. 2010
    ..Gene expression microarrays can reveal insights into disease biology and identify novel biomarkers. However, these experiments produce large datasets that are difficult to interpret...
  21. ncbi Validation of the internal reference technique for microdialysis measurements of interstitial histamine in the rat
    M Rizell
    Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden
    Life Sci 65:1765-71. 1999
    The internal reference technique (IRT) was compared with the no net flux method (NFM) as a microdialysis calibration technique for sampling of interstitial histamine in the rat...
  22. ncbi Heterodimeric associations between neuronal intermediate filament proteins
    E S Athlan
    Department of Biochemistry, McGill University, 3655 Drummond Street, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 272:31073-8. 1997
    Formation of protein dimers involving alpha-internexin, peripherin, and the neurofilament (NF) proteins NFH, NFM, and NFL was investigated by partial renaturation of various combinations of individually purified subunits in buffered 2 M ..
  23. ncbi Biocatalytic nylon nanofibrous membranes
    Alessandra Arecchi
    Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Universita di Milano, Via Celoria, 2, 20133 Milan, Italy
    Anal Bioanal Chem 398:3097-103. 2010
    Nylon-6 nanofibrous membranes (NFM) have been prepared, characterized and used to build-up electrochemical biosensing devices...
  24. ncbi Neurofilament metabolism in sporadic amyotrophic lateral sclerosis
    M J Strong
    The John P Robarts Research Institute, and the Department of Clinical Neurological Sciences, The University of Western Ontario, London, Ontario, Canada
    J Neurol Sci 169:170-7. 1999
    ..This occurred in the absence of modifications in NFH, NFM or neuronal nitric oxide synthase (Type I NOS; nNOS) steady state mRNA levels...
  25. ncbi The effect of lead on the avian auditory brainstem
    Diana I Lurie
    Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy and Allied Health Sciences, The University of Montana, Skaggs Building Room 304, 32 Campus Drive, Missoula, MT 59812 1552, USA
    Neurotoxicology 27:108-17. 2006
    ..However, Pb exposure does result in significant decreases in the amount of the medium weight neurofilament protein (NFM) as well as decreased NFM phosphorylation within the axons connecting auditory nuclei in the avian brainstem...
  26. ncbi Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells
    Tatiana Tondreau
    Institut Jules Bordet, Universite Libre de Bruxelles, Laboratory of Experimental Hematology, 121, Bd de Waterloo, 1000 Brussels, Belgium
    BMC Genomics 9:166. 2008
    ..Indeed, many studies have demonstrated that MSC can give rise to neuronal cells as well as many tissue-specific cell phenotypes...
  27. ncbi Nucleotide excision repair in yeast
    S Prakash
    Sealy Center for Molecular Science, University of Texas Medical Branch, 6 103 Medical Research Building, Galveston, TX 77555 1061, USA
    Mutat Res 451:13-24. 2000
    ..and Rad1-Rad10 form one subassembly called NEF1, the Rad4-Rad23 complex is named NEF2, Rad2 and TFIIH constitute NEF3, and the Rad7-Rad16 complex is called NEF4...
  28. ncbi Development and evaluation of new sustained-release floating microspheres
    Ninan Ma
    School of Pharmacy, Shenyang Pharmaceutical University, Wen Hua Road No 103, Shenyang, Liaoning Province, People s Republic of China
    Int J Pharm 358:82-90. 2008
    ..In contrast, non-floating system (NFM) could be emptied within 2.5h...
  29. ncbi Quantitative RT PCR approach to evaluate the neurogenic and gliagenic gene expression of cultured human amniotic epithelial cells
    G C Tan
    Department of Pathology, Universiti Kebangsaan Malaysia Medical Center
    Med J Malaysia 63:51-2. 2008
    ..the neural stem cell genes (Nestin, NSE and Vimentin), mature neuronal genes (TH, MAP-2, beta-III-tubulin and NFM) and glial genes (CNPase, MBP and Olig)...
  30. ncbi Accurate linear radiofrequency lesions guided by a nonfluoroscopic electroanatomic mapping method during atrial fibrillation
    L Gepstein
    Cardiovascular System Laboratory, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa
    Pacing Clin Electrophysiol 24:1672-8. 2001
    ..The accuracy of guiding the application of continuous RF lesions by a nonfluoroscopic mapping system (NFM) during AF in goats was tested...
  31. ncbi Release of folic acid in mesoporous NFM-1 silica
    Chunfang Zhou
    Nanologica AB, Drottning Kristinas väg 45, SE 114 28 Stockholm, Sweden
    J Nanosci Nanotechnol 10:7398-401. 2010
    Mesoporous NFM-1 silica with folic acid as template was prepared taking advantage of the supramolecular self-assembly of pterin groups and their abilities to form hexagonal liquid crystal phases...
  32. ncbi Cerebrospinal fluid and serum antibodies against neurofilaments in patients with amyotrophic lateral sclerosis
    L Fialova
    First Faculty of Medicine, Institute of Medical Biochemistry, Charles University, Prague, Czech Republic
    Eur J Neurol 17:562-6. 2010
    ..The aim of the study was to assess autoimmune involvement in amyotrophic lateral sclerosis (ALS)...
  33. ncbi Reduction of VOC emissions by a membrane-based gas absorption process
    Rui Li
    School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
    J Environ Sci (China) 21:1096-102. 2009
    ..using a hydrophobic polypropylene hollow fiber membrane contactor and the aqueous solution of N-formyl morpholine (NFM) as absorbent. The effects of various factors on the overall mass transfer coefficient was investigated...
  34. ncbi Surface modification of electrospun PLLA nanofibers by plasma treatment and cationized gelatin immobilization for cartilage tissue engineering
    Jyh Ping Chen
    Department of Chemical and Materials Engineering, Chang Gung University, Kwei San, Taoyuan, Taiwan, ROC
    Acta Biomater 7:234-43. 2011
    ..and to show in vitro and in vivo the potential applications of CG-grafted PLLA nanofibrous membranes (CG-PLLA NFM) as a cartilage tissue engineering scaffold...
  35. ncbi Optimized necrotic enteritis model producing clinical and subclinical infection of Clostridium perfringens in broiler chickens
    Shu Biao Wu
    School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia
    Avian Dis 54:1058-65. 2010
    ..perfringens but showed a significantly higher C. perfringens count than the non-fishmeal (NFM) control group...
  36. ncbi Time-dependent effects of elevated intraocular pressure on optic nerve head axonal transport and cytoskeleton proteins
    Chandrakumar Balaratnasingam
    Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Australia
    Invest Ophthalmol Vis Sci 49:986-99. 2008
    ..To study the time-dependent effects of elevated intraocular pressure (IOP) on axonal transport and cytoskeleton proteins in the porcine optic nerve head...
  37. ncbi Bioactive electrospun silver nanoparticles-containing polyurethane nanofibers as wound dressings
    Jyh Ping Chen
    Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 333, Taiwan, China
    J Nanosci Nanotechnol 10:7560-4. 2010
    Nanofibrous membrane (NFM) intended as wound dressing was prepared by electrospinning polyurethane (PU) solution containing silver ion, followed by reduction of silver ion to silver nanoparticles...
  38. ncbi [Nitrogen flow in farming-feeding system and its environmental impact in China]
    Min peng Chen
    Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China
    Huan Jing Ke Xue 28:2342-9. 2007
    By applying nitrogen flow model for farming-feeding system (NFM-FFS) which integrates soil full nitrogen balance model with inventory analysis for agricultural pollution, nitrogen flow in China farming-feeding systems and its ..
  39. ncbi Lead exposure during development results in increased neurofilament phosphorylation, neuritic beading, and temporal processing deficits within the murine auditory brainstem
    Linda G Jones
    Center for Environmental Health Sciences, The University of Montana, Missoula, Montana 59812, USA
    J Comp Neurol 506:1003-17. 2008
    ..contrast, Pb exposure alters neuronal structural proteins by inducing increased phosphorylation of both the medium (NFM) and high-weight (NFH) forms of neurofilament within auditory brainstem nuclei...
  40. ncbi Glutamate receptor pathology is present in the hippocampus following repeated sub-lethal soman exposure in the absence of spatial memory deficits
    Erik A Johnson
    US Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Comparative Medicine Division, Comparative Pathology Branch, Aberdeen Proving Ground, MD 21010 5400, USA
    Neurotoxicology 29:73-80. 2008
    ..No significant differences in neurofilament medium (NFM), neurofilament light (NFL) or synaptophysin densitometry were detected and alpha-II-spectrin proteolytic breakdown ..
  41. ncbi The influence of patterned nanofiber meshes on human mesenchymal stem cell osteogenesis
    Albino Martins
    Department of Polymer Engineering, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark, Zona Industrial da Gandra, S Cláudio do Barco, 4806 909 Caldas das Taipas, Guimaraes, Portugal
    Macromol Biosci 11:978-87. 2011
    A specially designed electroconductive collector enables the electrospinning of P-NFM composed of areas of parallel/uniaxially aligned fibers and areas of random/orthogonal nanofiber distribution...
  42. ncbi Effects of hot and cold foods on signals of heart rate variability and nail fold microcirculation of healthy young humans: a pilot study
    Dan Ping Chao
    Graduate Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, Republic of China
    Chin J Physiol 54:145-52. 2011
    ..We found that the capillary red blood cell (RBC) velocity in nail fold microcirculation (NFM) of the subjects with hot constitution accelerated significantly after taking the hot-attribute aged ginger tea, ..
  43. ncbi N-phenylmaleimide derivatives as mimetic agents of the pro-inflammatory process: myeloperoxidase activation
    Vânia F Noldin
    Department of Pharmaceutical Sciences, Center of Science and Health, Federal University of Santa Catarina, 88040 900 Florianopolis SC, Brazil
    Pharmacol Rep 63:772-80. 2011
    ..The synthetic compounds N-phenylmaleimide (NFM) and 4-methyl-N-phenylmaleimide (Me-NFM) increased the MPO activity in vitro (of isolated enzyme and in isolated ..
  44. ncbi Consumption of commercial whole and non-fat milk increases the incidence of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats
    Li Qiang Qin
    Department of Obstetrics and Gynecology, School of Medicine, Yamanashi University, Chuo City, Shimokato 1110, Yamanashi 409 3898, Japan
    Cancer Detect Prev 31:339-43. 2007
    ..Although the consumptions of milk and dairy products were considered to be a risk factor for breast cancer in some epidemiological studies, the results were inconsistent...
  45. ncbi Gamma-diketone axonopathy: analyses of cytoskeletal motors and highways in CNS myelinated axons
    Lihai Zhang
    Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10467 2490, USA
    Toxicol Sci 117:180-9. 2010
    ..Although previous mechanistic research focused on neurofilament triplet proteins (NFL, NFM, NFH), other cytoskeletal targets are possible...
  46. ncbi Functional neural differentiation of human adipose tissue-derived stem cells using bFGF and forskolin
    Sujeong Jang
    Department of Physiology, Chonnam National University Medical School, Gwangju 501190, Republic of Korea
    BMC Cell Biol 11:25. 2010
    ..We characterized the multipotent ability of human adipose tissue-derived stem cells (hADSCs) as MSCs and investigated the neural differentiation potential of these cells...
  47. ncbi Electrospun carbon nanotubes-gold nanoparticles embedded nanowebs: prosperous multi-functional nanomaterials
    Tae Gyung Kim
    Department of Nano Science and Technology, Kyungpook National University, Daegu, 702 701, Korea
    Nanotechnology 21:134021. 2010
    ..disperse multiwalled carbon nanotubes (MWNT) within electrospun polyvinylidene fluoride nanofibrous membranes (PVdF-NFM). Subsequently, MWNT(CD-IC)/PVdF-NFM was loaded with gold (Au) particles...
  48. ncbi Ordering off the menu: assessing compliance with a nonformulary medication policy
    Tara L Pummer
    School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Pharmacother 43:1251-7. 2009
    ..Institutional policies can support compliance with formulary systems and address these issues. However, periodic review is needed to assess the effectiveness of NFM policies.
  49. ncbi Comparative efficacy of oil solution and wettable powder of lambda-cyhalothrin to naturally occurring Ornithonyssus sylviarum infestation of chickens
    Baoliang Pan
    College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China
    Vet Parasitol 164:353-6. 2009
    The Northern Fowl Mite (NFM), Ornithonyssus sylviarum, is one of the most important and common pests of poultry...
  50. ncbi Electrospinning of poly(dimethylsiloxane)/poly(methyl methacrylate) nanofibrous membrane: fabrication and application in protein microarrays
    Dayong Yang
    Suzhou Institute of Nano tech and Nano bionics, Chinese Academy of Sciences, Suzhou 215125, China
    Biomacromolecules 10:3335-40. 2009
    ..The prepared PDMS/PMMA nanofibrous membrane (PDMS/PMMA NFM) was successfully used as substrates for protein microarrays...
  51. ncbi Synergy of serum and cerebrospinal fluid antibodies against axonal cytoskeletal proteins in patients with different neurological diseases
    L Fialova
    First Faculty of Medicine, Charles University in Prague, Institute of Medical Biochemistry, Prague, Czech Republic
    Folia Biol (Praha) 55:23-6. 2009
    Autoantibodies against different axonal cytoskeletal proteins [the light (NFL) and medium (NFM) subunit of neurofilament and tubulin (TUB)] in serum and cerebrospinal fluid may be generated in response to the release of cytoskeleton from ..
  52. ncbi Host inflammatory response governs fitness in an avian ectoparasite, the northern fowl mite (Ornithonyssus sylviarum)
    Jeb P Owen
    Department of Entomology, University of California, Riverside, CA 92521, USA
    Int J Parasitol 39:789-99. 2009
    ..This study focused on an ectoparasite of birds--the northern fowl mite (NFM) (Ornithonyssus sylviarum)...
  53. ncbi Copy number changes of the microcephalin 1 gene (MCPH1) in patients with autism spectrum disorders
    H M Ozgen
    Department of Child and Adolescent Psychiatry, University Medical Centre, Utrecht, The Netherlands
    Clin Genet 76:348-56. 2009
    ..1-> p21.2) containing at least three candidate genes; MCPH1 and DLGAP2 within the 6.9-Mb terminal deletion and NEF3 within the concomitant 14.1-Mb duplication...
  54. ncbi Simulating cranio-maxillofacial surgery based on mixed-element biomechanical modelling
    Shengzheng Wang
    Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, Shanghai 200240, China
    Comput Methods Biomech Biomed Engin 13:419-29. 2010
    ..This paper presents a nonlinear finite mixed-element model (NFM-EM) to enhance the tissue behaviour in the simulation...
  55. ncbi Neurofuzzy modeling to determine recurrence risk following radical cystectomy for nonmetastatic urothelial carcinoma of the bladder
    James W F Catto
    Department of Automatic Control and Systems Engineering, University of Sheffield, Sheffield, UK
    Clin Cancer Res 15:3150-5. 2009
    ..We developed a neurofuzzy model (NFM) to predict disease recurrence following RC and PLND in patients who are not usually administered adjuvant ..
  56. ncbi Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer
    R Tabares-Seisdedos
    Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, CIBER SAM, University of Valencia, Valencia, Spain
    Mol Psychiatry 14:563-89. 2009
    ..in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric ..
  57. ncbi Alterations in neurofilaments content and calpains activity of sciatic nerve of carbon disulfide-treated rats
    Fuyong Song
    Institute of Toxicology, Shandong University, 44 West Wenhua Road, 250012 Jinan, Shandong, People s Republic of China
    Arch Toxicol 83:587-94. 2009
    ..Furthermore, the levels of mRNA expression of NFH, NFM and NFL genes were up-regulated consistently in spinal cords of treated rats...
  58. ncbi The effect of mushroom and pokeweed extract on salmonella, egg production, and weight loss in molting hens
    W L Willis
    Department of Animal Sciences, North Carolina Agricultural and Technical State University, Greensboro 27411, USA
    Poult Sci 87:2451-7. 2008
    ..FFW), 2) full-fed + mushroom (FFM), 3) full-fed + pokeweed (FFP), 4) nonfed + H(2)0 (NFW), 5) nonfed + mushroom (NFM), 6) nonfed + pokeweed (NFP), 7) full-fed alfalfa meal + H(2)0 (FFAW), 8) full-fed alfalfa meal + mushroom (FFAM), ..
  59. ncbi Increased expression of cdk5/p25 in N2a cells leads to hyperphosphorylation and impaired axonal transport of neurofilament proteins
    Jie Zhou
    Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Life Sci 86:532-7. 2010
    ..The increased cdk5 expression and enhanced phosphorylation of tau and NFs have been seen in AD patients. Our study aimed at investigating the effects of increased cdk5 activity on axonal transport of neurofilaments (NFs)...
  60. ncbi Hierarchical starch-based fibrous scaffold for bone tissue engineering applications
    Albino Martins
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Portugal
    J Tissue Eng Regen Med 3:37-42. 2009
    ..microfibres in a grid-like arrangement, intercalated by a mesh-like structure with randomly distributed nanofibres (NFM)...
  61. ncbi Characterization of two proteolytically derived soluble polypeptides from the neurofilament triplet components NFM and NFH
    T K Chin
    Department of Biophysics, King s College London, U K
    Biochem J 264:53-60. 1989
    ..purified to homogeneity the regions derived by chymotryptic digestion of the ox neurofilament polypeptides NFH and NFM; the regions, called M1 and M2, are thought to form part of the projecting sidearms of mammalian neurofilaments [..
  62. ncbi Matrix metalloproteinase-9 promotes nerve growth factor-induced neurite elongation but not new sprout formation in vitro
    Veronica I Shubayev
    San Diego VA Healthcare System, San Diego, California, USA
    J Neurosci Res 77:229-39. 2004
    ..Finally, phosphorylated neurofilament M (NFM-p), a marker for regenerative elongation, was induced with MMP-9 treatment and was inhibited by the anti-..
  63. ncbi Negative neurofilament light and tau immunostaining in frontotemporal dementia
    Magnus Sjogren
    Department of Neuropsychiatry, Sahlgrenska University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 17:346-9. 2004
    We investigated the immunohistochemical stainability of phosphorylated tau and the light (NFL), intermediate (NFM), and heavy (NFH) neurofilament proteins in postmortem brain tissue from 8 patients with frontotemporal dementia (FTD), for ..
  64. ncbi Identification of endogenous phosphorylation sites of bovine medium and low molecular weight neurofilament proteins by tandem mass spectrometry
    Sarah Trimpin
    Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, USA
    Biochemistry 43:2091-105. 2004
    ..TOF) mass spectrometry (MS) shows molecular masses for bovine NFP subunits of 63, 105, and 125 kDa for NFL, NFM, and NFH...
  65. ncbi Neurobehavioral characteristics of mice with modified intermediate filament genes
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM, Rouen, France
    Rev Neurosci 14:369-85. 2003
    ..In addition, spatial learning was impaired in transgenic mice expressing transgenes for NFH and NFM, similar to the memory deficits reported in patients with ALS.
  66. ncbi Mutation analysis of the neurofilament M gene in Parkinson's disease
    Rejko Kruger
    Department of Neurology, Neurodegeneration Laboratory, University of Tubingen, Hoppe Seyler Strasse 3, D 72076, Tubingen, Germany
    Neurosci Lett 351:125-9. 2003
    b>Neurofilament M, a major component of Lewy bodies, represents an interesting candidate in the pathogenesis of Parkinson's disease (PD). We performed detailed mutation analyses of the NF-M gene in 322 familial and sporadic PD patients...
  67. ncbi Charcot-Marie-Tooth disease with giant axons: a clinicopathological and genetic entity
    G Lus
    Department of Neurological Sciences, First Division of Clinical Neurology, Faculty of Medicine, Second University of Naples and Interuniversity Center for Research in Neuroscience, Naples, Italy
    Neurology 61:988-90. 2003
    ..This family with CMT and giant axons has a pathologic and genetic entity distinct from classic CMT...
  68. ncbi Does diabetes target ganglion neurones? Progressive sensory neurone involvement in long-term experimental diabetes
    D W Zochodne
    Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Brain 124:2319-34. 2001
    ..assessed using quantitative in situ hybridization studies for mRNA markers that included alpha CGRP, beta CGRP, NFM, t alpha 1-tubulin, SP, VIP, B50 (GAP43), galanin, somatostatin, PACAP, HSP27, c-jun, SNAP 25, p75, TrkA, TrkB and ..
  69. ncbi Topical application of garlic reduces northern fowl mite infestation in laying hens
    G P Birrenkott
    Department of Animal and Veterinary Sciences, Clemson University, South Carolina 29634 0361, USA
    Poult Sci 79:1575-7. 2000
    Northern fowl mites (NFM) are external parasites that can lower egg production and cause anemia and even death in laying hens. An experiment was conducted with New Hampshire Red and Single Comb White Leghorn laying hens...
  70. ncbi Identification of the major multiphosphorylation site in mammalian neurofilaments
    V M Lee
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia
    Proc Natl Acad Sci U S A 85:1998-2002. 1988
    ..e., MAP2 and tau...
  71. ncbi The DNA-dependent ATPase activity of yeast nucleotide excision repair factor 4 and its role in DNA damage recognition
    S N Guzder
    Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, Texas 77555 1061, USA
    J Biol Chem 273:6292-6. 1998
    ..that inclusion of NEF4 to the reconstituted nucleotide excision repair system consisting of purified NEF1, NEF2, NEF3, and replication protein A results in marked stimulation of damage-specific DNA incision...
  72. ncbi RFLP for BgI II at the human neurofilament medium chain (NEF3) gene locus
    Y Ding
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104-6141
    Nucleic Acids Res 20:1429. 1992
  73. ncbi Yeast Rad7-Rad16 complex, specific for the nucleotide excision repair of the nontranscribed DNA strand, is an ATP-dependent DNA damage sensor
    S N Guzder
    Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, Texas 77555 1061, USA
    J Biol Chem 272:21665-8. 1997
    ..DNA damage sensor that specifically functions with the ensemble of nucleotide excision repair factor (NEF) 1, NEF2, NEF3, and replication protein A in the repair of transcriptionally inactive DNA...
  74. ncbi Cytoplasmic O-GlcNAc modification of the head domain and the KSP repeat motif of the neurofilament protein neurofilament-H
    D L Dong
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 271:20845-52. 1996
    ..The proximity of O-GlcNAc and phosphorylation sites in both head and tail domains of each subunit indicates that these modifications may influence one another and play a role in filament assembly and network formation...
  75. ncbi Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M
    D L Dong
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 268:16679-87. 1993
    ..Specific identification of these O-GlcNAc attachment sites has set the stage for more detailed mutagenic analysis of O-GlcNAc functions on neurofilaments...
  76. ncbi Sequence and structure of the mouse gene coding for the largest neurofilament subunit
    J P Julien
    Institut du Cancer de Montreal, Centre Hospitalier Notre Dame, Canada
    Gene 68:307-14. 1988
    ..The nfh gene shares two common intron positions with the nfl and nfm genes, but has an additional intron that occurs at a location equivalent to one of the introns in non-neuronal ..
  77. ncbi The G336S variant in the human neurofilament-M gene does not affect its assembly or distribution: importance of the functional analysis of neurofilament variants
    Raul Perez-Olle
    Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA
    J Neuropathol Exp Neurol 63:759-74. 2004
    ..Our data suggest that if the G336S variant is involved in the development of PD, it does not appear to be due to defects in the assembly and distribution of NFs...
  78. ncbi Fine localization of Nefl and Nef3 and its exclusion as candidate gene for lens rupture 2(lr2)
    Sang Dal Rhee
    Korea Research Institute of Chemical Technology, Yusong gu, Taejon
    Exp Anim 53:295-301. 2004
    ..Components of neurofilament proteins, neurofilament light polypeptide (Nefl) and neurofilament3 medium (Nef3), were linked to D14Mit87 which was not separated from the lr2 locus in the homozygosity mapping...
  79. ncbi Neuronal cytoskeletal alterations in an experimental model of depression
    A Reines
    Instituto de Investigaciones Farmacológicas ININFA, CONICET, Buenos Aires, Argentina
    Neuroscience 129:529-38. 2004
    ..Microtubule-associated protein 2 (MAP-2) and light (NFL; 68 kDa), medium (NFM; 160 kDa) and heavy (NFH; 200 kDa) neurofilament subunit immunostainings were analyzed employing morphometric ..
  80. ncbi Differential expression of cytoskeletal genes in the cochlear nucleus
    David R Friedland
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:447-65. 2006
    ..e., Nefh, Nef3, and Nfl) among the subdivisions of the cochlear nucleus...
  81. ncbi Neuro-fuzzy modeling: an accurate and interpretable method for predicting bladder cancer progression
    James W F Catto
    Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    J Urol 175:474-9. 2006
    ..b>NFM is an alternate form of artificial intelligence using fuzzy logic (which is a multivalued logic which provides ..
  82. ncbi Fortifying milk with ferrous gluconate and zinc oxide in a public nutrition program reduced the prevalence of anemia in toddlers
    Salvador Villalpando
    Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    J Nutr 136:2633-7. 2006
    ..28 mg/400 mL of zinc as zinc oxide, and 48 mg/400 mL of ascorbic acid, or nonfortified milk (NFM) with 0.2 mg iron/400 mL, 1.9 mg zinc/400 mL, and 6.8 mg ascorbic acid/400 mL...
  83. ncbi Biodegradable polymer nanofiber mesh to maintain functions of endothelial cells
    Wei He
    Division of Bioengineering, National University of Singapore, Singapore
    Tissue Eng 12:2457-66. 2006
    ..Mechanical testing showed that tensile modulus and strength were greater for the aligned P(LLA-CL) NFM than for the random NFM...
  84. ncbi Electrospun poly(vinylidene fluoride)/poly(aminophenylboronic acid) composite nanofibrous membrane as a novel glucose sensor
    K M Manesh
    Department of Chemistry Graduate School, Kyungpook National University, Daegu 702 701, South Korea
    Anal Biochem 360:189-95. 2007
    Electrospinning was used to prepare the nanofibrous membrane (NFM) of the composite comprising poly(vinylidene fluoride) and poly(aminophenylboronic acid) (PVdF/PAPBA-NFM)...
  85. ncbi Mutation analysis of patients with neuronal intermediate filament inclusion disease (NIFID)
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute on Aging, Porter Neuroscience Building, Building 35 Room 1A1010 35 Convent Drive, Bethesda, MD 20892, USA
    Neurobiol Aging 27:778.e1-778.e6. 2006
    Abnormal neuronal aggregates of alpha-internexin and the three neurofilament (NF) subunits, NFL, NFM, and NFH have recently been identified as the signature lesions of neuronal intermediate filament (IF) inclusion disease (NIFID), a ..
  86. ncbi Fabrication of collagen-coated biodegradable polymer nanofiber mesh and its potential for endothelial cells growth
    Wei He
    Division of Bioengineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore
    Biomaterials 26:7606-15. 2005
    ..The aim of this study was to design a nanofiber mesh (NFM) that facilitates viability, attachment and phenotypic maintenance of human coronary artery endothelial cells (..
  87. ncbi Performance of a neuro-fuzzy model in predicting weight changes of chronic schizophrenic patients exposed to antipsychotics
    T H Lan
    Department of Psychiatry, Yu Li Hospital, Department of Health, Yu Li, Hualien County, Taiwan
    Mol Psychiatry 13:1129-37. 2008
    ..Here we examined the performance of neuro-fuzzy modeling (NFM) in predicting weight changes in chronic schizophrenic patients exposed to antipsychotics...
  88. ncbi Sphere formation and expression of neural proteins by human corneal stromal cells in vitro
    Saiko Uchida
    Department of Ophthalmology, Tokyo University School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Invest Ophthalmol Vis Sci 46:1620-5. 2005
    ..To demonstrate the presence of corneal stromal precursors that express neural markers in vitro...
  89. ncbi Pre- and postweaning attributes in faunated and ciliate-free calves fed calf starter with or without fish meal
    A Sahoo
    Rumen Microbiology Section, Animal Nutrition Division, Indian Veterinary Research Institute Izatnagar 243 122 UP, India
    J Dairy Sci 88:2027-36. 2005
    ..were distributed in 4 equal groups involving dietary treatments of prestarter diets with (FM) or without fish meal (NFM) in a faunated (F) or ciliate-free (D) ruminal environment to study the ruminal fermentative development in pre-and ..
  90. ncbi How the projection domains of NF-L and alpha-internexin determine the conformations of NF-M and NF-H in neurofilaments
    F A M Leermakers
    Wageningen University, The Netherlands
    Eur Biophys J 39:1323-34. 2010
    ..Replacing all L-tails by alpha-projections destroys the substructure of the NF corona and this alters the NF response to the phosphorylation of long tails...
  91. ncbi Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis
    Ales Bartos
    Charles University in Prague, Third Faculty of Medicine, Dept of Neurology, University Hospital Kralovske Vinohrady, Srobarova 50, 100 34, Prague 10, Czech Republic
    J Neurol 254:20-5. 2007
    ..Both immunoglobulin G (IgG) and M (IgM) responses against the purified native medium subunit of neurofilaments (NFM) using enzyme-linked immunosorbent assay (ELISA) were determined in paired serum and cerebrospinal fluid samples ..
  92. ncbi Characterization of olfactory bulb glomeruli in schizophrenia
    Lise Rioux
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Schizophr Res 77:229-39. 2005
    ..The absence of change in the level of poorly phosphorylated neurofilament of moderate and high molecular weight (NFM/HP) suggested no lack of dendritic innervation despite a previously seen reduction of glomerular MAP2 level in ..
  93. ncbi Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins
    L M Fleming
    Department of Psychiatry, University of Alabama, Birmingham, 35294 0017, USA
    Exp Neurol 138:252-60. 1996
    ..recombinant tau (T4L), the shortest isoform of human recombinant tau (T3), and the 160-kDa neurofilament protein (NFM). ApoE4 did not bind T3, T4L, or NFM in this assay...
  94. ncbi The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family
    M W Myers
    EMBO J 6:1617-26. 1987
    ..This finding suggests a common origin of the neurofilament subunits, whose evolutionary relationship to other intermediate filament genes is uncertain...
  95. ncbi Phosphoproteomic analysis of synaptosomes from human cerebral cortex
    Joseph A DeGiorgis
    Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Proteome Res 4:306-15. 2005
    ..The study shows that new phosphoproteomic strategies can be used to analyze subcellular fractions from small amounts of tissue for the identification of phosphorylated residues for research and potentially for diagnostic purposes...
  96. ncbi Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis
    Michael L Garcia
    Ludwig Institute for Cancer Research and Department of Neurosciences, University of California at San Diego, 9500 Gilman Drive, CMM E Room 3072, La Jolla, CA 92093 0670, USA
    Neurobiol Dis 21:102-9. 2006
    ..Thus, mutations in neurofilaments are possible risk factors that may contribute to pathogenesis in ALS in conjunction with one or more additional genetic or environmental factors, but are not significant primary causes of ALS...
  97. ncbi Association of the dopamine receptor interacting protein gene, NEF3, with early response to antipsychotic medication
    Rael D Strous
    Beer Yaakov Mental Health Center, Beer Yaakov and Sackler Faculty of Medicine, Tel Aviv, Israel
    Int J Neuropsychopharmacol 10:321-33. 2007
    ..Twenty-two single nucleotide polymorphisms (SNPs) were analysed in five DRIP-encoding genes. Two SNPs in NEF3, which encodes the DRIP, neurofilament-medium (NF-M), were associated with early response (rs1457266, p=0...
  98. ncbi Transcription of intermediate filament genes is enhanced in focal cortical dysplasia
    J P Taylor
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Acta Neuropathol 102:141-8. 2001
    ..Radiolabeled aRNA from single neurons was used to probe cDNA arrays containing the low (NFL), medium (NFM) and high (NFH) molecular weight neurofilament isoform, alpha-internexin, desmin, vimentin, peripherin (PRPH), ..
  99. ncbi O-glycosylation of the tail domain of neurofilament protein M in human neurons and in spinal cord tissue of a rat model of amyotrophic lateral sclerosis (ALS)
    Nina Lüdemann
    Department of Neurobiology, University of Osnabruck, Barbarastrasse 11, D 49076 Osnabrück
    J Biol Chem 280:31648-58. 2005
    ....
  100. ncbi [Detection of level and mutation of neurofilament mRNA in Alzheimer's disease]
    Yipeng Wang
    Department of Pathophysiology, Research Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Yi Xue Za Zhi 82:519-22. 2002
    ..To study if the increase of levels of neurofilament (NF)-M and NF-L in brain of Alzheimer's diseases (AD) is caused by increase of NF-M and NF-L...
  101. ncbi Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins
    Kiran Bhaskar
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
    Neurochem Int 44:35-44. 2004
    ....

Research Grants26

  1. DYNAMICS OF THE NEURONAL CYTOSKELETON IN AGING BRAIN
    Ralph A Nixon; Fiscal Year: 2010
    ..We identified the middle subunit of NF (NFM) as uniquely crucial for NF transport and key NF scaffold functions...
  2. DYNAMICS OF THE NEURONAL CYTOSKELETON IN AGING BRAIN
    Ralph Nixon; Fiscal Year: 2006
    ..We propose to identify this site of phosphorylation on NFH and NFM subunits and define its regulation by protein kinases and phosphatases in vivo (Aim 1)...
  3. FUSION PROTEINS IN THE MOLECULAR PATHOGENESIS OF APL
    Pier Paolo Pandolfi; Fiscal Year: 1999
    ..tge breakpoints lie within the RARalpha locus on chromosomes 17, the PNL gave on 15, the PLZF gene on 11 and the NFM gene on chromosome 5...
  4. Neurofilaments, SOD1 and Motor Neuron Diseases
    Don Cleveland; Fiscal Year: 2007
    ..Using gene replacement in mice to produce NFM that cannot be phosphorylated or that mimics phosphorylation, the effects of eliminating or chronically modifying ..
  5. Organ lumen morphogenesis in C. elegans
    VERENA GOBEL; Fiscal Year: 2004
    ..Transgenic lines expressing fluorescently labeled apical (ERM-1::GFP) versus basolateral (NFM-1 ::GFP) epithelial membrane markers of the three tubular organs will be screened by genome-wide RNA interference (..
  6. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2007
    ..This proposal aims to determine the value of MMPs as biomarkers of neurodegeneration that could be used for the early diagnosis of neurodegenerative disease and the efficacy of neuroprotective therapy to spinal cord injury. ..
  7. MT COBRE: EFFECT OF LEAD ON DEVELOPMENT OF AUDITORY TEMPORAL PROCESSING
    DIANA LURIE; Fiscal Year: 2006
    ..These results, combined with our previous studies of Pb on the avian CNS and on avian behavior have resulted in a submission of a major grant proposal to the NIH. ..
  8. Differential Gene Expression in the Cochlear Nucleus
    David Friedland; Fiscal Year: 2007
    ..These data will also provide a powerful template upon which to test and design novel treatments for improving hearing, discrimination and tinnitus in a significant portion of the population. ..
  9. Genetic Control of Olfactory Bulb Size in Schizophrenia
    Lise Rioux; Fiscal Year: 2006
    ....
  10. Hippocampal Retinoid Pathway in Schizophrenia
    Lise Rioux; Fiscal Year: 2002
    ..A correlation between RAR expression and Fyn or GAP-43 expression will better define the role of retinoid dysfunction in relation to memory and learning deficits in schizophrenia. ..
  11. Transduction of the Mouse Auditory System with AAV
    DIANA LURIE; Fiscal Year: 2003
    ..The focus of these future studies will be on delivering specific genes to the auditory system that potentially play a role in both the functional recovery of the cochlea, as well as neuroprotection following cochlear damage. ..
  12. Markers of olfactory neurotransmission in Schizophrenia
    Lise Rioux; Fiscal Year: 2004
    ..The effect of the antipsychotic on the expression of these proteins will also be investigated in mice chronically treated with haloperidol to discriminate between disease- and treatment related changes. ..
  13. EFFECT OF LEAD ON THE DEVELOPMENT OF AUDITORY TEMPORAL PROCESSING
    DIANA LURIE; Fiscal Year: 2002
    ..If so, the definition of a minimal toxic lead level in children will need to be reduced below the 10 p.g/dLstandard currently in use. ..