MYCL1

Summary

Gene Symbol: MYCL1
Description: v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)
Alias: LMYC, MYCL, bHLHe38, class E basic helix-loop-helix protein 38, l-myc-1 proto-oncogene, myc-related gene from lung cancer, protein L-Myc-1
Species: human

Top Publications

  1. ncbi Alterations in exon 1 of c-myc and expression of p62c-myc in cervical squamous cell carcinoma
    J J O'Leary
    Nuffield Department of Pathology and Bacteriology, University of Oxford, UK
    J Clin Pathol 50:896-903. 1997
  2. ncbi Novel mutation in the KCNQ4 gene in a large kindred with dominant progressive hearing loss
    Z Talebizadeh
    Center for Hereditary Communication Disorders, Boys Town National Research Hospital, Omaha, Nebraska
    Hum Mutat 14:493-501. 1999
  3. ncbi Two haplotypes of 5' untranslated region in L-myc gene with different internal ribosome entry site activity
    Hiroshi Kumimoto
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Oncol 26:287-93. 2005
  4. ncbi Biological characteristics of neuroblastoma with partial deletion in the short arm of chromosome 1
    E Hiyama
    Department of General Medicine, Hiroshima University School of Medicine, Japan
    Med Pediatr Oncol 36:67-74. 2001
  5. ncbi Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: genetic reclassification and correlation with clinical features
    U Schiemann
    Medizinische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Digestion 69:166-76. 2004
  6. ncbi Molecular analysis of primary and recurrent giant cell tumors of bone
    Uma N M Rao
    Department of Pathology, University of Pittsburgh Medical Center Presbyterian Shadyside, Room WG02 9, 5230 Centre Avenue, Pittsburgh, PA 15213, USA
    Cancer Genet Cytogenet 158:126-36. 2005
  7. ncbi Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification
    Y H Kim
    Department of Pathology, Stanford University, Stanford, CA 94305 5176, USA
    Oncogene 25:130-8. 2006
  8. ncbi Genome wide copy number abnormalities in pediatric medulloblastomas as assessed by array comparative genome hybridization
    Ken C Lo
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Brain Pathol 17:282-96. 2007
  9. ncbi Myc proteins as therapeutic targets
    W C Gustafson
    Department of Pediatrics, University of California, San Francisco, CA 94158 9001, USA
    Oncogene 29:1249-59. 2010
  10. ncbi Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family
    J Spring
    Joint Program in Neonatology, Harvard Medical School, Boston, Massachusetts 02115
    Genomics 21:597-601. 1994

Research Grants

  1. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    Kathleen R Cho; Fiscal Year: 2010
  2. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    KATHLEEN CHO; Fiscal Year: 2009
  3. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    KATHLEEN CHO; Fiscal Year: 2007
  4. Mutational load in buccal cells from lung cancer patients and controls
    Robbert Slebos; Fiscal Year: 2007
  5. Molecular Pathogenesis of Ovarian Endometrioid Adenocarc
    KATHLEEN CHO; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications76

  1. ncbi Alterations in exon 1 of c-myc and expression of p62c-myc in cervical squamous cell carcinoma
    J J O'Leary
    Nuffield Department of Pathology and Bacteriology, University of Oxford, UK
    J Clin Pathol 50:896-903. 1997
    ..To examine human papillomavirus (HPV) positive and negative squamous cell carcinomas of the cervix for structural alterations in exon 1 c-myc; and to investigate the expression pattern of p62, the protein product of c-myc...
  2. ncbi Novel mutation in the KCNQ4 gene in a large kindred with dominant progressive hearing loss
    Z Talebizadeh
    Center for Hereditary Communication Disorders, Boys Town National Research Hospital, Omaha, Nebraska
    Hum Mutat 14:493-501. 1999
    ..6 for the marker MYCL1 at straight theta = 0.0...
  3. ncbi Two haplotypes of 5' untranslated region in L-myc gene with different internal ribosome entry site activity
    Hiroshi Kumimoto
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Oncol 26:287-93. 2005
    ..C-8G showed approximately 2-fold higher IRES activity than A-9G in both cos 7 and HeLa S3 cells, suggesting that two polymorphisms in the L-myc exon 1 might be involved in regulation of L-myc protein expression...
  4. ncbi Biological characteristics of neuroblastoma with partial deletion in the short arm of chromosome 1
    E Hiyama
    Department of General Medicine, Hiroshima University School of Medicine, Japan
    Med Pediatr Oncol 36:67-74. 2001
    ..We also found that the unfavorable neuroblastoma often have a loss of heterozygosity (LOH) at the MYCL locus.
  5. ncbi Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: genetic reclassification and correlation with clinical features
    U Schiemann
    Medizinische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Digestion 69:166-76. 2004
    ..As a consequence, tumors in HNPCC reveal alterations in the length of simple repetitive genomic sequences like poly-A, poly-T, CA or GT repeats (microsatellites) in at least 90% of the cases...
  6. ncbi Molecular analysis of primary and recurrent giant cell tumors of bone
    Uma N M Rao
    Department of Pathology, University of Pittsburgh Medical Center Presbyterian Shadyside, Room WG02 9, 5230 Centre Avenue, Pittsburgh, PA 15213, USA
    Cancer Genet Cytogenet 158:126-36. 2005
    ..Involvement of 1p (including MYCL) and 9q regions has not been previously reported in GCT of bone...
  7. ncbi Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification
    Y H Kim
    Department of Pathology, Stanford University, Stanford, CA 94305 5176, USA
    Oncogene 25:130-8. 2006
    ..DNA amplifications corresponding to oncogenes known to be amplified in SCLC, including MYC (8q24), MYCN (2p24) and MYCL1 (1p34)...
  8. ncbi Genome wide copy number abnormalities in pediatric medulloblastomas as assessed by array comparative genome hybridization
    Ken C Lo
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Brain Pathol 17:282-96. 2007
    ..Amplifications in this series included MYCL, MYCN and MYC previously implicated in medulloblastoma pathogenesis, as well as novel amplicons on chromosomes 2, 4,..
  9. ncbi Myc proteins as therapeutic targets
    W C Gustafson
    Department of Pediatrics, University of California, San Francisco, CA 94158 9001, USA
    Oncogene 29:1249-59. 2010
    Myc proteins (c-myc, Mycn and Mycl) target proliferative and apoptotic pathways vital for progression in cancer...
  10. ncbi Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family
    J Spring
    Joint Program in Neonatology, Harvard Medical School, Boston, Massachusetts 02115
    Genomics 21:597-601. 1994
    ..Synd1 is next to Nmyc, Synd2 close to myc, Synd3 near Lmyc, and Synd4 on the same chromosome as Bmyc...
  11. ncbi A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes
    Zunyan Dai
    Program of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH, 43210, USA
    Hum Mol Genet 12:791-801. 2003
    ..one novel amplicon on chromosome 11q22, in addition to previously reported amplicons that include oncogenes MYCC, MYCL1 and previously identified amplification of chromosomal regions 6q21 and 3q26-27...
  12. ncbi Association of L-myc polymorphism with lung cancer susceptibility and prognosis in relation to age-selected controls and stratified cases
    Chuen Ming Shih
    Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan, ROC
    Lung Cancer 36:125-32. 2002
    ..004, by the log rank test). These data suggest that the S allele of the L-myc polymorphism may be associated with lung cancer progression...
  13. ncbi A new polymorphism (Ser362Thr) of the L-myc gene is not associated with lung adenocarcinoma risk and prognosis
    M Spinola
    Department of Experimental Oncology Thoracic Surgery Pathology, Istituto Nazionale Tumori, Milan, Italy
    Eur J Cancer Prev 13:87-9. 2004
    ..Thus, the present results do not support candidacy of the L-myc Ser362Thr polymorphism for the functional polymorphism of the L-myc genomic region...
  14. ncbi New insights into testicular germ cell tumorigenesis from gene expression profiling
    Rolf I Skotheim
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    Cancer Res 62:2359-64. 2002
    ..Several genes novel to testicular tumorigenesis were consistently up- or down-regulated, including POV1, MYCL1, MYBL2, MXI1, and DNMT2...
  15. ncbi Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ
    Hanne Primdahl
    Department of Clinical Biochemistry, Aarhus University Hospital at Skejby, 8200 Aarhus N, Denmark
    Oncol Rep 9:551-5. 2002
    ..Allelic deletions in urine sediments seem to be at least as common in patients with carcinoma in situ as in patients with bladder tumors...
  16. ncbi Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer
    Takeshi Kambara
    Department of Gastroenterological Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Clin Cancer Res 10:1758-63. 2004
    ..Our aim in the present study was to determine whether allelic losses on 1p were likely to be of much value in predicting the prognosis of CRC cases...
  17. ncbi Is there any correlation between restriction fragment length polymorphism of the L-MYC gene and metastasis of human nonsmall cell lung cancer?
    Ilhan Yaylim
    Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Istanbul, Turkey
    Cancer Genet Cytogenet 134:118-22. 2002
    ..Our results suggested that L-myc gene polymorphism was not a suitable prognostic marker of metastatic development in Turkish NSCLC patients...
  18. ncbi Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review)
    Deyin Xing
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, China
    Oncol Rep 10:1615-23. 2003
    ..For polymorphisms in GSTT1, XPD, CCND1, and L-Myc, the risk estimate from the studies was sufficiently precise to exclude an OR >/=1.5...
  19. ncbi MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis
    K Demopoulos
    Department of Virology, Medical School, University of Crete, P O Box 1393, Heraklion, Crete, Greece
    J Cell Mol Med 6:215-22. 2002
    ..3, 3p21.32-p21.1, 5q32-q33.1, 9p21 and 17p13.1 where MYCL1, FHIT, SPARC, p16(Ink4) and TP53 genes have been mapped respectively...
  20. ncbi Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas
    Rong Wu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Pathol 162:1603-10. 2003
    ..The data implicate L-MYC gene amplification and/or overexpression in human OvCa pathogenesis...
  21. ncbi Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas
    Xin Mao
    Skin Tumour Unit and Dermatopathology Department, St John s Institute of Dermatology, St Thomas Hospital, London, United Kingdom
    Blood 101:1513-9. 2003
    ..syndrome (SS) (71%), gains of FGFR1 (8p11), PTPN (20q13), and BCR (22q11) in 4 cases (57%), and gains of MYCL1 (1p34), PIK3CA (3q26), HRAS (11p15), MYBL2 (20q13), and ZNF217 (20q13) in 3 cases (43%)...
  22. ncbi Yaf2 inhibits Myc biological function
    Britta Mädge
    Division of Cytogenetics H0400, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Lett 193:171-6. 2003
    The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors...
  23. ncbi Meta-analysis suggests association of L-myc EcoRI polymorphism with cancer prognosis
    Monica Spinola
    Department of Experimental Oncology, Istituto Nazionale Tumori, and Molecular and Genetic Epidemiology Unit, Ospedale Policlinico IRCCS, Milan, Italy
    Clin Cancer Res 10:4769-75. 2004
    ..8; 95% CI, 1.2-2.9), and cancer risk (OR, 1.25; 95% CI, 1.07-1.45). The meta-analysis suggests that the L-myc EcoRI polymorphism is a marker of tumor prognosis in lung cancer and possibly in other types of cancer...
  24. ncbi Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma
    Thaddeus D Allen
    G W Hooper Research Foundation, University of California, San Francisco, San Francisco, California 94143 0552, USA
    Cancer Res 71:6010-8. 2011
    ..Interestingly, Myc and MycL1 were expressed in the adenomas, suggesting that selection for enhanced Myc activity may facilitate tumorigenesis...
  25. ncbi A 5'-region polymorphism modulates promoter activity of the tumor suppressor gene MFSD2A
    Francesca Colombo
    Department of Predictive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Mol Cancer 10:81. 2011
    The MFSD2A gene maps within a linkage disequilibrium block containing the MYCL1-EcoRI polymorphism associated with prognosis and survival in lung cancer patients...
  26. ncbi Genetic variation in an miRNA-1827 binding site in MYCL1 alters susceptibility to small-cell lung cancer
    Fang Xiong
    Department of Medical Oncology, Chinese Academy of Medical Sciences, Beijing, China
    Cancer Res 71:5175-81. 2011
    ..We identified 2 SNPs, rs3134615 and rs2291854, which were located in the 3'-UTR of the L-MYC gene MYCL1 and the neuronal development Achaete-Scute Complex homolog ASCL1...
  27. ncbi Association of a MYCL1 single nucleotide polymorphism, rs3134613, with susceptibility to diffuse-type gastric cancer and with differentiation of gastric cancer in a southeast Chinese population
    Shu Qin Chen
    Key laboratory of Ministry of Education for Gastrointestinal Cancer, Research Center of Molecular Medicine, Fujian Medical University, Fuzhou, China
    DNA Cell Biol 29:739-43. 2010
    A MYCL1 single nucleotide polymorphism, rs3134613, has been reported to play an important role in many cancers. However, its involvement in gastric cancer is controversial...
  28. ncbi MYC in oncogenesis and as a target for cancer therapies
    Ami Albihn
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Adv Cancer Res 107:163-224. 2010
    MYC proteins (c-MYC, MYCN, and MYCL) regulate processes involved in many if not all aspects of cell fate...
  29. ncbi Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists
    Parveen Bhatti
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Radiat Res 173:214-24. 2010
    ..Even though a complete understanding of the way(s) in which these variants may increase breast cancer risk remains elusive, this approach may yield clues for further investigation...
  30. ncbi Cell proliferation-related genetic polymorphisms and gastric cancer risk: systematic review and meta-analysis
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Eur J Hum Genet 17:1658-67. 2009
    ..Larger studies are warranted to clarify the effect of cell proliferation-related genetic polymorphisms on gastric carcinogenesis...
  31. ncbi Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc
    Kelly G Paulson
    Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    J Invest Dermatol 129:1547-55. 2009
    ..RB1, and a previously unreported focal amplification at 1p34 was present in 39% of tumors and centers on L-Myc (MYCL1)...
  32. ncbi L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers
    Aydin Gozu
    Department of Plastic and Reconstructive Surgery, Vakif Gureba Research and Education Hospital, Istanbul, Turkey
    Arch Otolaryngol Head Neck Surg 134:725-8. 2008
    ..To evaluate the presence of L-myc gene variations as a genetic predisposition to head and neck nonmelanoma skin cancer (HNNMSC) and lower lip cancer (LLC)...
  33. ncbi L-myc gene polymorphism and risk of thyroid cancer
    I Yaylim-Eraltan
    Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Istanbul Research and Education Hospital, Surgery Clinic, Istanbul, Turkey
    Exp Oncol 30:117-20. 2008
    ..L-myc gene polymorphism is a representative genetic trait responsible for an individual's susceptibility to several cancers. However, there have been no reports concerning the association between thyroid cancer and L-myc gene polymorphism...
  34. ncbi Filiform serrated adenomas: a clinicopathologic and immunophenotypic study of 18 cases
    Rhonda K Yantiss
    Weill Medical College of Cornell University, Department of Pathology, New York, NY 10021, USA
    Am J Surg Pathol 31:1238-45. 2007
    ..loci evaluated, including 1 at D5S346 [adenomatous polyposis coli (APC) gene], 1 at D17S250 (p53 gene), and 2 at MYCL (chromosome 1p34)...
  35. ncbi Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival
    Monica Spinola
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Milan, Italy
    Lung Cancer 55:271-7. 2007
    ..a region associated with lung cancer progression on chromosome 1p34 identified a 106 kb LD block that includes MYCL1, TRIT1 (tRNA isopentenyltransferase 1) and MFSD2 (major facilitator superfamily domain-containing 2)...
  36. ncbi Mutagenic effect of cadmium on tetranucleotide repeats in human cells
    Robbert J C Slebos
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mutat Res 602:92-9. 2006
    ..For this study, we selected a panel of three hypermutable tetranucleotide markers (MycL1, D7S1482 and DXS981) and studied their suitability as readout for the mutagenic effects of cadmium...
  37. ncbi High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumors
    Martin Gerard McCabe
    Department of Pathology, University of Cambridge, Division of Molecular Histopathology, UK
    J Neuropathol Exp Neurol 65:549-61. 2006
    ..Novel amplifications were identified, some encompassing oncogenes MYCL1, PDGFRA, KIT, and MYB not previously reported to show amplification in these tumors...
  38. ncbi Detection of occult high graded microsatellite instabilities in MMR gene mutation negative HNPCC tumors by addition of complementary marker analysis
    U Schiemann
    Medizinsche Klinik und Poliklinik, Ludwig Maximilians Universitat, Munchen, Germany
    Eur J Med Res 10:23-8. 2005
    ..In 90% of the cases, molecular analyses reveal microsatellite instabilities due to germline mutations in DNA mismatch repair (MMR) genes, mainly MLH1, MSH2, among these tumors...
  39. ncbi Loss of heterozygosity and allelic imbalance in apocrine metaplasia of the breast: microdissection microsatellite analysis
    Abdel Ghani A Selim
    Department of Histopathology, St Bartholomew s Hospital, St Bartholomew s and the Royal London School of Medicine and Dentistry, University of London, West Smithfield, London EC1A 7BE, UK
    J Pathol 196:287-91. 2002
    ..Occasional examples of LOH and/or AI were identified in 2/28 (7.1%) informative cases at 1p (MYCL1), 2/14 (14.3%) at 11q (INT2), 1/15 (6.7%) at 13q (D13S267), 3/22 (13.6%) at 16q (D16S539), 2/23 (8...
  40. ncbi Close correlation between restriction fragment length polymorphism of L-myc gene and susceptibility to gastric cancer
    Turgay Isbir
    Department of Molecular Medicine, Institute of Experimental Medical Research, University of Istanbul, DETAE 34390, P O Box 7 Capa, Istanbul, Turkey
    Cancer Detect Prev 26:454-7. 2002
    ..Our aim was to test the hypothesis that there was association between L-myc S allele in gastric cancer and predisposition to the disease...
  41. ncbi Exclusion of the familial melanoma locus (MLM) from the PND/D1S47 and MYCL1 regions of chromosome arm 1p in 7 Australian pedigrees
    D J Nancarrow
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Herston, Australia
    Genomics 12:18-25. 1992
    ..In addition, we can exclude a region of about 20 cM around the MYCL1/D1S57 loci.
  42. ncbi The human myc gene family: structure and activity of L-myc and an L-myc pseudogene
    R A DePinho
    Howard Hughes Medical Institute, New York
    Genes Dev 1:1311-26. 1987
    ..Our analyses clearly prove that L-myc represents a functional member of the myc oncogene family and further delineate structural features that may be important for the common and divergent functions of the members of this gene family...
  43. ncbi The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs
    J de Greve
    National Cancer Institute and Naval Hospital, Bethesda, Maryland 20814
    Mol Cell Biol 8:4381-8. 1988
    ..These observations suggest that alternative RNA processing of the L-myc transcript could play a role in determining the steady-state levels of the p60L-myc and p66L-myc proteins...
  44. ncbi Structure and expression of the murine L-myc gene
    E Legouy
    Department of Biochemistry, College of Physicians and Surgeons of Columbia University, New York, NY 10032
    EMBO J 6:3359-66. 1987
    ..We discuss these findings in the context of potential functional domains and the possibility of overlapping and distinct activities of myc-family proteins...
  45. ncbi Chromosome localization and expression pattern of Lmyc and Bmyc in murine embryonal carcinoma cells
    S Ingvarsson
    Department of Tumor Biology, Karolinska Institutet, Stockholm, Sweden
    Oncogene 3:679-85. 1988
    Using Southern blot analysis of DNA from mouse-hamster somatic cell hybrids, we have mapped Lmyc and Bmyc, two members of the myc family of genes, to mouse chromosomes 4 and 2, respectively...
  46. ncbi A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes
    J D Ceci
    Mammalian Genetics Laboratory, BRI Basic Research Program, NCI Frederick Cancer Research Facility, Maryland 21701
    Genomics 5:699-709. 1989
    ..common sites of viral integration have been assigned regional locations on chromosome 4 including Mos, Lyn, Jun, Lmyc, Lck, Fgr, and Dsi-1. Additional loci mapped in this study to chromosome 4 were Tsha, Mup-1, Rrm2-ps1, Ifa, and Anf...
  47. ncbi The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences
    N Ikegaki
    Department of Human Genetics, University of Pennsylvania, School of Medicine, Philadelphia, 19104
    EMBO J 8:1793-9. 1989
    ..The short form polypeptides have a half-life of approximately 120-180 min. The L-myc protein is not detectable in the mitotic cells, suggesting that the L-myc protein expression is tightly regulated during the cell cycle...
  48. ncbi Mapping and characterization of an X-linked processed gene related to MYCL1
    C C Morton
    Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02115
    Genomics 4:367-75. 1989
    ..to the myc family of proto-oncogenes has been characterized and found to be a processed gene related to L-MYC (MYCL1)...
  49. ncbi Alterations of oncogenes in metastatic tumours of human gastric carcinomas
    T Tsujino
    First Department of Pathology, Hiroshima University School of Medicine, Japan
    Br J Cancer 62:226-30. 1990
    ..sites in 12 autopsy cases of gastric carcinomas were analysed for alterations of ERBB, ERBB2, HST1, INT2 and LMYC genes by Southern blot hybridisation...
  50. ncbi Assignment of 12 loci to rat chromosome 5: evidence that this chromosome is homologous to mouse chromosome 4 and to human chromosomes 9 and 1 (1p arm)
    C Szpirer
    Universite Libre de Bruxelles, Departement de Biologie Moleculaire, Rhode St Genese, Belgium
    Genomics 6:679-84. 1990
    ..on human chromosome 9 (interferon alpha and beta, galactosyltransferase, orosomucoid, and aldolase B genes) and on the short arm of human chromosome 1 (MYCL, glucose transporter, protein kinase LCK, and atrial natriuretic factor genes).
  51. ncbi Immunohistochemical demonstration of altered intracellular localization of the C-Myc oncogene product in human colorectal neoplasms
    A R Williams
    Department of Pathology, University of Edinburgh, U K
    J Pathol 160:287-93. 1990
    ..The distribution of the c-myc oncogene product p62 was examined by immunohistochemistry using the monoclonal antibody Mycl-9E10 in a series of 50 colorectal resections for carcinoma...
  52. ncbi IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis
    T Moroy
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    EMBO J 9:3659-66. 1990
    ..However, the Emu-L-myc tumors do not express detectable levels of endogenous myc family genes indicating that the L-myc protein can substitute for c- or N-myc in the generation and growth of lymphoid neoplasms...
  53. ncbi Genetic mapping of meander tail, a mouse mutation affecting cerebellar development
    C Fletcher
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Genomics 9:647-55. 1991
    ..The loci included in this analysis are Calb, Ggtb, Lv, b, Ifa, mea, D4Rp1, Glut-1, Lck, Lmyc-1, and Eno-1. This analysis positions the mea phenotypic locus in the interval between Ifa and Glut1...
  54. ncbi Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc
    E M Blackwood
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Science 251:1211-7. 1991
    ..These results suggest that Myc family proteins undergo a restricted set of interactions in the cell and may belong to the more general class of eukaryotic DNA-binding transcription factors...
  55. ncbi A linkage map of distal mouse chromosome 12
    M Cho
    Department of Biochemistry, NYU Medical Center, NY 10016
    Mamm Genome 1:30-6. 1991
    ..variants detected with the creatine kinase probe allowed definition of four additional genetic loci: Ck-1 near Lmyc-1 on Chromosome 4; Ck-2 between Upg-1 and Hprt-ps1 (D17Rp10) on distal Chromosome 17; Ck-4 near Mpmv-17 and Mls-3 ..
  56. ncbi Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes
    J Santos
    Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, NY 10016
    Cytogenet Cell Genet 62:217-9. 1993
    DNA probes for the NRAS, HRAS, KRAS2, LCK, RAF1, MET, MYCL1, MYCN, MYB, ERBB2, FOS, CSF1R, and SRC protooncogene loci; the retinoblastoma gene locus (RB1); the tumor virus integration sites INT2, PVT1, and MLV12; and the locus of the ..
  57. ncbi Chromosomal localization of four human zinc finger cDNAs
    K Huebner
    Jefferson Cancer Institute, Thomas Jefferson Medical College, Philadelphia, PA 19107
    Hum Genet 91:217-22. 1993
    ..carries many ZNF loci and other genes with zinc finger encoding motifs; the pT3 clone additionally detected a locus designated ZNF78L2, which mapped to chromosome region 1p, most likely in the region 1p32 where the MYCL and JUN loci map.
  58. ncbi Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor
    S Sinha
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genomics 37:260-3. 1996
    ..We assigned the mouse CBF-C gene (designated Nfyc) to chromosome 4 with tight linkage to Lmyc. Our mouse linkage data suggest that the human NFYC homolog will map to 1p32.
  59. ncbi Genome wide detection of oncogene amplifications in nasopharyngeal carcinoma by array based comparative genomic hybridization
    Angela Bik Yu Hui
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong, P R China
    Int J Oncol 20:467-73. 2002
    ..Non-random gene amplifications were identified for the first time in NPC on MYCL1 in 1p34.3 and on TERC and PIK3CA at 3q26.3...
  60. ncbi L-myc genotype is associated with different susceptibility to lung cancer in smokers
    Hiroshi Kumimoto
    Central Laboratory and Radiation Biology, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Jpn J Cancer Res 93:1-5. 2002
    ..The OR for smoking in SS-genotype patients diagnosed within 2 years was higher than that in other SS patients, suggesting that smoking-related lung cancer in SS genotype might exhibit a poorer prognosis...
  61. ncbi [Deletion of YNZ22 and ALU-VPA/MYCL1 loci in human colonic adenocarcinoma and postoperative prognosis]
    K N Kashkin
    Mol Biol (Mosk) 35:798-804. 2001
    ..Analysis of both YNZ22 and Alu-VpA/MycL1 (1p34.3) loci in the tumor allowed reliable relapse prognosis in 76% of the CC patients...
  62. ncbi Function and regulation of the transcription factors of the Myc/Max/Mad network
    B Luscher
    Abt Biochemie und Molekularbiologie, Institut fur Biochemie, Universitätsklinikum der RWTH, Pauwelstrasse 30, 52057 Aachen, Germany
    Gene 277:1-14. 2001
    ..Thus the antagonism of Myc and Mad proteins is explained at the molecular level by the recruitment of opposing chromatin remodeling activities...
  63. ncbi Different susceptibility of each L-myc genotype to esophageal cancer risk factors
    H Kumimoto
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Jpn J Cancer Res 92:735-9. 2001
    ..40, respectively. The age-sex-adjusted ORs for both factors combined were 12.77, 18.45 and 1.44, respectively. These results suggested that the L-myc polymorphism might modify the effects of lifestyle factors on esophageal cancer risk...
  64. ncbi A Dutch family with progressive sensorineural hearing impairment linked to the DFNA2 region
    R J Ensink
    Department of Otorhinolaryngology and Head Neck Surgery, University Hospital, Nijmegen, The Netherlands
    Eur Arch Otorhinolaryngol 257:62-7. 2000
    ..Linkage to DFNA2 was established with maximum lod scores of 4.7 and 3.2 for the flanking markers of the DFNA2 region (D1S432;MYCL1).
  65. ncbi Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN
    D Bannasch
    Division of Cytogenetics H0400, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Oncogene 18:6810-7. 1999
    ..Therefore only a very small amount of MycN and Nmi is likely to be involved in MycN/Nmi interaction in vivo...
  66. ncbi Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc
    M J FitzGerald
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118, USA
    Oncogene 18:2489-98. 1999
    ....
  67. ncbi Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2
    E Redolfi
    Istituto di Tecnologie Biomediche Avanzate, CNR, Segrate, Italy
    FEBS Lett 446:273-7. 1999
    ..Based on computer analysis, the MYC-like sequence (MYCL3) is 98.2% identical to a portion of exon 3 of the MYCL1 gene and maps to the Xq27.2 region, between the DXS312 and DXS292 loci.
  68. ncbi Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization
    F Speleman
    Department of Medical Genetics, University Hospital, Gent, Belgium
    Cytogenet Cell Genet 72:189-90. 1996
    b>MYCL1 has been previously mapped to 1p32. This position was in contradiction with our mapping data of 1p deletions in neuroblastoma cell lines...
  69. ncbi MYCL genotypes and loss of heterozygosity in non-small-cell lung cancer
    K M Fong
    Department of Pathology, University of Queensland Medical School, Herston, Australia
    Br J Cancer 74:1975-8. 1996
    Some studies have suggested that the S allele of the MYCL oncogene, which results from an intragenic EcoRI restriction fragment length polymorphism (RFLP), may be associated with cancer susceptibility...
  70. ncbi Linkage analysis of progressive hearing loss in five extended families maps the DFNA2 gene to a 1.25-Mb region on chromosome 1p
    G Van Camp
    Department of Medical Genetics, University of Antwerp UIA, Belgium
    Genomics 41:70-4. 1997
    ..25-Mb region between markers D1S432 and MYCL1. Different haplotypes segregating with the hearing loss were found in all five families, suggesting that different ..
  71. ncbi Delivery to cancer cells of antisense L-myc oligonucleotides incorporated in fusogenic, cationic-lipid-reconstituted influenza-virus envelopes (cationic virosomes)
    E R Waelti
    Institute of Pathology, University of Bern, Switzerland
    Int J Cancer 77:728-33. 1998
    ..These results suggest that cationic virosomes may have great potential as an efficient delivery system for antisense oligonucleotides in cancer therapy...
  72. ncbi Testis-specific expression of the human MYCL2 gene
    N G Robertson
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115
    Nucleic Acids Res 19:3129-37. 1991
    We have characterized the expression of MYCL2, an intronless X-linked gene related to MYCL1. RNase protection analysis of a panel of human normal and tumor tissues has revealed that MYCL2 is expressed almost exclusively in human adult ..
  73. ncbi Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing
    F Kaye
    NCI Navy Medical Oncology Branch, Naval Hospital, Bethesda, Maryland
    Mol Cell Biol 8:186-95. 1988
    ..In contrast, other mRNA transcripts, generated by alternative processing, could encode a truncated protein with a novel carboxy-terminal end...
  74. ncbi EcoRI polymorphism of the L-myc gene in gastric cancer patients
    Aldona Dlugosz
    Department of Gastroenterology, Pomeranian Academy of Medicine, Szczecin, Poland
    Eur J Gastroenterol Hepatol 14:1231-5. 2002
    ....
  75. ncbi Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner
    W R Atchley
    Department of Genetics, North Carolina State University, Raleigh 27695 7614, USA
    Proc Natl Acad Sci U S A 92:10217-21. 1995
    ..It is suggested that the reduced variability in max stems from natural selection acting to preserve dimerization capability with products of myc and related genes...
  76. ncbi L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma
    Hiroaki Suzuki
    Department of Clinical Research, Sapporo National Hospital, Shiroishi ku, Sapporo 003 0804, Japan
    Oncol Rep 9:345-7. 2002
    ..Our results showed that the L-myc RFLP is not a strong prognostic marker compared with histologic pattern of invasion in lung adenocarcinoma...

Research Grants16

  1. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    Kathleen R Cho; Fiscal Year: 2010
    ....
  2. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    KATHLEEN CHO; Fiscal Year: 2009
    ....
  3. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    KATHLEEN CHO; Fiscal Year: 2007
    ....
  4. Mutational load in buccal cells from lung cancer patients and controls
    Robbert Slebos; Fiscal Year: 2007
    ....
  5. Molecular Pathogenesis of Ovarian Endometrioid Adenocarc
    KATHLEEN CHO; Fiscal Year: 2006
    ..abstract_text> ..