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Genomes and Genes | MMP24SummaryGene Symbol: MMP24 Description: matrix metallopeptidase 24 (membrane-inserted) Alias: MMP25, MT-MMP5, MT5-MMP, MMP-24, MT-MMP 5, MT5MMP, MTMMP5, matrix metalloproteinase 24 (membrane-inserted), matrix metalloproteinase-24, membrane-type 5 matrix metalloproteinase, membrane-type matrix metalloproteinase 5, membrane-type-5 matrix metalloproteinase Species: human Top Publications
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Publications
Matrix metalloproteinases and their tissue inhibitors in cuprizone-induced demyelination and remyelination of brain white and gray matterJelena Skuljec
Department of Neurology, Hannover Medical School, Hannover, Germany
J Neuropathol Exp Neurol 70:758-69. 2011..b>Matrix metalloproteinase 24 mRNA was downregulated during both demyelination and remyelination...- Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genesClara L Sampieri
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
Matrix Biol 27:128-38. 2008..Anisomycin alone induced MMP9 and TIMP3, along with MMP25 and MMP19... - Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosisRegine Gaetje
Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
Gynecol Endocrinol 23:567-73. 2007..Various members of the MMPs also seem to play an important role in the invasion process of endometriosis; however, so far only a limited number of studies have focused on membrane-associated MMPs... - Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signallingBlair Hopwood
Division of Tissue Pathology, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia, 5000, Australia
Arthritis Res Ther 9:R100. 2007..of these genes are targets of either the WNT (wingless MMTV integration) signalling pathway (TWIST1, IBSP, S100A4, MMP25, RUNX2 and CD14) or the transforming growth factor (TGF)-beta/bone morphogenic protein (BMP) signalling pathway (.. - Oxidised, glycated LDL selectively influences tissue inhibitor of metalloproteinase-3 gene expression and protein production in human retinal capillary pericytesJ L Barth
Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC, USA
Diabetologia 50:2200-8. 2007.... - The role of stratifin in fibroblast-keratinocyte interactionAbelardo Medina
BC Professional Fire Fighters Burn and Wound Healing Laboratory, Division of Plastic Surgery, University of British Columbia, Vancouver, BC, Canada
Mol Cell Biochem 305:255-64. 2007..In this review, we will focus on site of synthesis and mode of action of stratifin in skin and wound healing... - MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical propertiesQing Sun
Department of Pathology and Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
J Biol Chem 282:21998-2010. 2007b>MMP25 (MT6-MMP) is one of the two glycosylphosphatidylinositol-anchored matrix metalloproteinases (MMPs) that have been suggested to play a role in pericellular proteolysis... - Immunoscreening of a cutaneous T-cell lymphoma library for plasma membrane proteinsMieun Lee
Skin Cancer Unit D070, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Cancer Immunol Immunother 56:783-95. 2007..Further analysis will unravel whether the list of identified proteins harbors candidates, which might be accessible for antibodies from outside the cell... - [Analysis of differential expression genes related to different metastasis potential of adenoid cystic carcinoma using restriction fragments differential display PCR]You guang Lu
Department of Anatomy, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041 PR China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:505-10. 2006..To construct differential expression profiles of adenoid cystic carcinoma cell lines for screening candidate genes related to metastasis and to verify some candidate genes in adenoid cystic carcinoma... - Membrane localization of membrane type 5 matrix metalloproteinase by AMPA receptor binding protein and cleavage of cadherinsSara Monea
Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 26:2300-12. 2006.... - Identification of a novel human MT5-MMP transcript variant in multipotent NT2 cellsHeather H Ross
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, VA, United States
FEBS Lett 581:5923-8. 2007..In vitro, MT5-MMPvar translated into a approximately 55 kDa protein. It was also detected in NT2, hNT and adult human hippocampus. These results suggest more than one human MT5-MMP transcript may exist in the central nervous system... - Pericellular-acting proteases in human first trimester deciduaMargreet Plaisier
Division of Reproductive Medicine, Department of Gynaecology, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands
Mol Hum Reprod 14:41-51. 2008..These data are consistent with a differential regulation of pericellular proteases in decidua by pregnancy-induced hormones, immune cells and EVT... - New signaling pathways from cancer progression modulators to mRNA expression of matrix metalloproteinases in breast cancer cellsGregory S Delassus
Department of Pathology, Saint Louis University School of Medicine, St Louis, Missouri 63104 1004, USA
J Cell Physiol 226:3378-84. 2011..The MMPs tested are MMP1, MMP2, MMP7, MMP13, MMP14, MMP16, MMP19, and MMP25. The proteins that were overexpressed are cancer inhibitors (NME, DRG1, IL10), enhancers (SOD2, FAK, IL17, and .. - Many new down- and up-regulatory signaling pathways, from known cancer progression suppressors to matrix metalloproteinases, differ widely in cells of various cancersGregory S Delassus
Department of Pathology, Saint Louis University School of Medicine, St Louis, Missouri 63104 1004, USA
J Cell Physiol 224:549-58. 2010..interleukin 4, p16(INK4alpha), p53, PTEN, and RKIP, and on MMP1, MMP2, MMP7, MMP13, MMP14, MMP16, MMP19, and MMP25. To this end, in the present study we tested the effects of raising the cellular levels of wild-type copies of .. - Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulationAlicia R Folgueras
Departamento de Bioquímica y Biología Molecular and Laboratorio de Farmacología, Facultad de Medicina, Instituto Universitario de Oncologia, Universidad de Oviedo, 33006 Oviedo, Spain
Proc Natl Acad Sci U S A 106:16451-6. 2009..We report that MT5-MMP is expressed by CGRP-containing peptidergic nociceptors in dorsal root ganglia and that Mmp24-deficient mice display enhanced sensitivity to noxious thermal stimuli under basal conditions... - The nutrigenomics of asthma: molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawalKatherine J Baines
Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan NSW Australia
OMICS 13:355-65. 2009..the innate immune receptors TLR2, IL1R2, CD93, the signaling molecules IRAK2, IRAK3, and neutrophil proteases MMP25 and CPD... - [Inhibitory effects of RNA interference on MMP-24 expression and invasiveness of ovarian cancer SKOV(3) cells]Ya ping Luo
Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Nan Fang Yi Ke Da Xue Xue Bao 29:781-4. 2009..To investigate the inhibitory effect of RNA interference (RNAi) on MMP-24 expression and invasiveness of ovarian cancer SKOV(3) cells... - Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosisSergey A Shiryaev
Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, California, United States of America
PLoS ONE 4:e4952. 2009..The splice variants of the single MBP gene (Golli-MBP BG21 and J37) are widely expressed in the neurons and also in the immune cells. The relative contribution of the individual MMPs to the MBP cleavage is not known... - Identification and role of the homodimerization interface of the glycosylphosphatidylinositol-anchored membrane type 6 matrix metalloproteinase (MMP25)Huiren Zhao
Department of Pathology, Wayne State University and Proteases and Cancer Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
J Biol Chem 283:35023-32. 2008The membrane type (MT) 6 matrix metalloproteinase (MMP) (MMP25) is a glycosylphosphatidylinositol-anchored matrix metalloproteinase (MMP) that is highly expressed in leukocytes and in some cancer tissues... - Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortionsM Plaisier
Department Biomedical Research, Gaubius Laboratory TNO Quality and Life, PB Box 2215, Leiden 2301 CE, The Netherlands
Hum Reprod 24:185-97. 2009..This study analysed decidual vascular adaptation to implantation in correlation with miscarriage in decidual secretory endometrium (DSE), decidua parietalis (DP) and decidua basalis (DB) of miscarriage patients and matched controls... - MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancerAnjum Sohail
Department of Pathology, School of Medicine, and Proteases and Cancer Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
Cancer Metastasis Rev 27:289-302. 2008..Finally, we comment on the new scientific challenges that lie ahead to better understand the function and role in cancer of these intriguing but yet unique MMPs... - The role of matrix metalloproteinases in the morphogenesis of the cerebellar cortexJia Luo
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, Morgantown, West Virginia, USA
Cerebellum 4:239-45. 2005..The potential contributions of these enzymes to granule neuron migration, Purkinje cell dendritogenesis and synaptogenesis are discussed... - Tissue mRNA expression in rat of newly described matrix metalloproteinasesFabian Bernal
Department of Neurology, Research Group for Clinical and Experimental Neuroimmunology, Heinrich Heine University, Dusseldorf, Germany
Biol Res 38:267-71. 2005..The present study highlights the differential distribution pattern of newly described MMPs among different tissues and underlines differences in the mRNA expression between different species... - Upregulated expression of human membrane type-5 matrix metalloproteinase in kidneys from diabetic patientsA M Romanic
Department of Cardiovascular Pharmacology, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
Am J Physiol Renal Physiol 281:F309-17. 2001..These results provide the first evidence of the expression of a MT-MMP in diabetes and suggest a novel role for MT5-MMP in the pathogenesis of renal tubular atrophy and end-stage renal disease... - Expression and localization of transcripts of MT5-MMP and its related MMP in the ovary of the medaka fish Oryzias latipesA Kimura
Division of Biological Sciences, Graduate School of Science, Hokkaido University, 060 0810, Sapporo, Japan
Biochim Biophys Acta 1518:115-23. 2001..These results strongly suggest that a MT5-MMP/gelatinase A cascade may possibly operate in the process of spawning and/or other events associated with ovulated oocytes or fertilized eggs of the medaka fish... - Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain-specific MMP highly expressed in cerebellumY Sekine-Aizawa
Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198 Japan
Eur J Neurosci 13:935-48. 2001.... - Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25)W R English
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
FEBS Lett 491:137-42. 2001..the biochemical characterisation of the catalytic domain of membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP25, leukolysin)... - Developmental regulation of membrane type-5 matrix metalloproteinase (MT5-MMP) expression in the rat nervous systemD M Jaworski
Department of Anatomy, University of Vermont College of Medicine, Given C454, Burlington, VT, USA
Brain Res 860:174-7. 2000..Membrane type-5 MMP is predominantly expressed in the brain. The present report is the first to demonstrate the temporal regulation and spatial distribution of MT5-MMP mRNA during nervous system development... - Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2-->H Kinoh
Department of Cancer Cell Research, Institute of Medical Science, The University of Tokyo, Japan
Cytogenet Cell Genet 87:97-8. 1999 - Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineageD Pei
Department of Pharmacology, University of Minnesota, Minneapolis 55455, USA
Cell Res 9:291-303. 1999..Taken together, leukolysin may be part of the proteolytic arsenal deployed by leukocytes during inflammatory responses. Molecular cloning of a novel MMP: MMP:25.. - Expression, purification and characterization of recombinant mouse MT5-MMP protein productsX Wang
Department of Pharmacology, University of Minnesota, Minneapolis 55455, USA
FEBS Lett 462:261-6. 1999We have recently identified the fifth member of the membrane-type matrix metalloproteinase subfamily, MT5-MMP/MMP24, which is expressed in a brain specific manner (Duanqing Pei (1999) J. Biol. Chem. 274, 8925-8932)... - Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumorsE Llano
Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Oviedo, Spain
Cancer Res 59:2570-6. 1999..These data suggest that MT5-MMP may contribute to the activation of progelatinase A in tumor tissues, in which it is overexpressed, thereby facilitating tumor progression... - Membrane-type 5 matrix metalloproteinase is expressed in differentiated neurons and regulates axonal growthH Hayashita-Kinoh
Division of Cancer Cell Research, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, 108 8639, Japan
Cell Growth Differ 12:573-80. 2001..Thus, MT5-MMP expressed in neurons may play a role in axonal growth that contributes to the regulation of neural network formation... - Screening of novel matrix metalloproteinases (MMPs) in human fetal membranesStephen J Fortunato
The Perinatal Research Center of The Women s Health Research and Education Foundation, Nashville, Tennessee 37203, USA
J Assist Reprod Genet 19:483-6. 2002..The objective of this study is to document the expression pattern of most of the MMPs cloned and sequenced so far in amniochorion during preterm premature rupture of membranes (pPROM), at term not in labor and during term labor... - Elastin-derived peptides enhance angiogenesis by promoting endothelial cell migration and tubulogenesis through upregulation of MT1-MMPArnaud Robinet
Laboratoire de Biochimie et Biologie Moleculaire, CNRS UMR 6198, IFR 53 Biomolecules, Faculte de Medecine, Universite de Reims Champagne Ardenne, 51 rue Cognacq Jay, 51095 Reims Cedex, France
J Cell Sci 118:343-56. 2005..Finally, the effect of elastin peptides on pseudotube formation in MT1-MMP-siRNA transfected cells was totally abolished. These data emphasise the crucial role of MT1-MMP in the elastin-induced angiogenic phenotype of endothelial cells... - Structure and expression of Furin mRNA in the ovary of the medaka, Oryzias latipesKatsueki Ogiwara
Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060 0810, Japan
J Exp Zool A Comp Exp Biol 301:449-59. 2004..Temporary and spatial expression patterns of the medaka fish furin were similar to those of stromelysin-3 and MT5-MMP during oocyte growth and postnatal development... - Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWVPing Wang
Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
J Biol Chem 279:20461-70. 2004..Furthermore, Mint-3 significantly increased the level of MT5-MMP on the cell surface without affecting its synthesis and internalization. Therefore, Mints may be the adaptor proteins that regulate the trafficking of MT-MMPs... - Association of chromosomal regions 3p21.2, 10p13, and 16p13.3 with nonsyndromic cleft lip and palateSusan H Blanton
University of Virginia, Charlottesville, Virginia, USA
Am J Med Genet A 125:23-7. 2004..3, and 16q12-13, and the region containing the WNT5A gene on chromosome 3p21. Markers from three of the regions, 10p13, 16p13.3 (MMP25), and 3p21.2, yielded findings that are sufficiently significant to warrant closer investigation. - Absence of mechanical allodynia and Abeta-fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinaseKiyoshi Komori
Department of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
FEBS Lett 557:125-8. 2004..These findings suggest that MT5-MMP is essential for the development of mechanical allodynia and plays an important role in neuronal plasticity in this mouse model... - Threonine 98, the pivotal residue of tissue inhibitor of metalloproteinases (TIMP)-1 in metalloproteinase recognitionMeng Huee Lee
Cambridge Institute for Medical Research, Wellcome Trust Medical Research Council Building, Cambridge University, Cambridge CB2 2XY, United Kingdom
J Biol Chem 279:17562-9. 2004..Not only have we unlocked the molecular basis for the inactivity of TIMP-1 against several of the MPs, but also our findings fundamentally modify the current beliefs on the molecular mechanism of TIMP-MP recognition and selectivity... - Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bondJing Nie
Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Cancer Res 63:6758-62. 2003..Taken these facts together, we conclude that MT6-MMP may participate in tumor invasion and metastasis by directly converting proMMP-2 into active form... - Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinasesTakahisa Takino
Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
Oncogene 22:4617-26. 2003..We propose that metastin could be used as an antimetastatic agent in combination with MMP inhibitor, or MMP-resistant forms of metastin could be developed and may also be efficacious... - mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissueMonika Jung
Department of Urology, University Hospital Charite, Humboldt University Berlin, Berlin, Germany
Prostate 55:89-98. 2003.... - Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMPD Pei
Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Biol Chem 274:8925-32. 1999..Taken together, these properties serve to distinguish MT5-MMP as a versatile MT-MMP playing an important role in extracellular matrix remodeling events in the brain and during embryonic development...
Research Grants
- The rpL7a in neuronal developmentJia Luo; Fiscal Year: 2006..Furthermore, the studies will provide an important insight into the mechanisms of extra-ribosomal function of ribosomal proteins. ..