MITF

Summary

Gene Symbol: MITF
Description: microphthalmia-associated transcription factor
Alias: WS2, WS2A, bHLHe32, class E basic helix-loop-helix protein 32
Species: human

Top Publications

  1. ncbi c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi
    M Wu
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 14:301-12. 2000
  2. ncbi Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, Oxted, Surrey, RH8 0TL, United Kingdom
    Genes Dev 20:3426-39. 2006
  3. ncbi Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance
    K Takeda
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Hum Mol Genet 9:125-32. 2000
  4. ncbi Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF
    Jinyan Du
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Boston Children s Hospital, Boston, MA 02115, USA
    Cancer Cell 6:565-76. 2004
  5. ncbi MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
    T J Hemesath
    Division of Pediatric Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 391:298-301. 1998
  6. ncbi Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9
    W Xu
    Roy M and Phyllis Gough Huffington Center on Aging, Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza M320 and VAMC, Houston, Texas, 77030, USA
    Exp Cell Res 255:135-43. 2000
  7. ncbi Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF
    Claudia Wellbrock
    Signal Transduction Team, The Institute of Cancer Research, Cancer Research UK Centre of Cell and Molecular Biology, London, United Kingdom
    PLoS ONE 3:e2734. 2008
  8. ncbi Pigmentation-related genes and their implication in malignant melanoma susceptibility
    Lara P Fernandez
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid E 28029, Spain
    Exp Dermatol 18:634-42. 2009
  9. ncbi Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
    Levi A Garraway
    Department of Medical Oncology, and Melanoma Program in Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 436:117-22. 2005
  10. ncbi Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling
    Kim C Mansky
    Department of Molecular Genetics and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 277:11077-83. 2002

Research Grants

  1. ATF2 in melanoma development and progression
    ZE apos EV A RONAI; Fiscal Year: 2010
  2. Characterization of neural crest stem cells in human hair follicles.
    Xiaowei Xu; Fiscal Year: 2010
  3. Mi: Modulating Osteoclast Gene Expression and Function
    Michael Ostrowski; Fiscal Year: 2009
  4. Signaling Pathways for UV-Induced Melanogenic Responses
    Zalfa Abdel Malek; Fiscal Year: 2007
  5. Mi: Modulating Osteoclast Gene Expression and Function
    Michael C Ostrowski; Fiscal Year: 2010
  6. Mitf: A Master Gene for Melanocyte Development
    David E Fisher; Fiscal Year: 2010
  7. Mitf: A Master Gene for Melanocyte Development
    David Fisher; Fiscal Year: 2007
  8. The role of Mc1r in melanocytic UV-induced DNA damage and repair responses
    JOHN A DORAZIO; Fiscal Year: 2010
  9. Mitf: A Master Gene for Melanocyte Development
    David E Fisher; Fiscal Year: 2010
  10. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications181 found, 100 shown here

  1. ncbi c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi
    M Wu
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 14:301-12. 2000
    ....
  2. ncbi Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, Oxted, Surrey, RH8 0TL, United Kingdom
    Genes Dev 20:3426-39. 2006
    ..in melanomas invasiveness can be regulated epigenetically by the microphthalmia-associated transcription factor, Mitf, via regulation of the DIAPH1 gene encoding the diaphanous-related formin Dia1 that promotes actin polymerization ..
  3. ncbi Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance
    K Takeda
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Hum Mol Genet 9:125-32. 2000
    b>MITF (microphthalmia-associated transcription factor) is a basic-helix-loop-helix-leucine zipper (bHLHZip) factor which regulates expression of tyrosinase and other melanocytic genes via a CATGTG promoter sequence, and is involved in ..
  4. ncbi Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF
    Jinyan Du
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Boston Children s Hospital, Boston, MA 02115, USA
    Cancer Cell 6:565-76. 2004
    ..expression, CDK2 exhibits tissue-specific regulation by the essential melanocyte lineage transcription factor MITF. In addition, functional studies revealed this regulation to be critical for maintaining CDK2 kinase activity and ..
  5. ncbi MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
    T J Hemesath
    Division of Pediatric Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 391:298-301. 1998
    ..The pathway represents a new application of the general MAP kinase machinery in transducing a signal between a tissue-specific receptor at the cell surface and a tissue-specific transcription factor in the nucleus...
  6. ncbi Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9
    W Xu
    Roy M and Phyllis Gough Huffington Center on Aging, Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza M320 and VAMC, Houston, Texas, 77030, USA
    Exp Cell Res 255:135-43. 2000
    The basic helix-loop-helix/leucine zipper (bHLH/ZIP) microphthalmia-associated transcription factor (MITF) regulates transcription of genes encoding enzymes essential for melanin biosynthesis in melanocytes and retinal pigmented ..
  7. ncbi Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF
    Claudia Wellbrock
    Signal Transduction Team, The Institute of Cancer Research, Cancer Research UK Centre of Cell and Molecular Biology, London, United Kingdom
    PLoS ONE 3:e2734. 2008
    The Microphthalmia-associated transcription factor (MITF) is an important regulator of cell-type specific functions in melanocytic cells...
  8. ncbi Pigmentation-related genes and their implication in malignant melanoma susceptibility
    Lara P Fernandez
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid E 28029, Spain
    Exp Dermatol 18:634-42. 2009
    ..that had been mainly associated with congenital pigmentation syndromes (ADTB3A, ATRN, CHS1, EDNRB, HPS, KIT, MGRN1, MITF, MLANA, MYO5A, MYO7A, OA1, OCA2, PAX3 and SOX10) were selected...
  9. ncbi Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
    Levi A Garraway
    Department of Medical Oncology, and Melanoma Program in Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 436:117-22. 2005
    ..maps with gene expression signatures derived from NCI60 cell lines, we identified the melanocyte master regulator MITF (microphthalmia-associated transcription factor) as the target of a novel melanoma amplification...
  10. ncbi Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling
    Kim C Mansky
    Department of Molecular Genetics and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 277:11077-83. 2002
    ..The microphthalmia transcription factor (MITF) is required for terminal differentiation of osteoclasts...
  11. ncbi Frequent mutations in the MITF pathway in melanoma
    Julia C Cronin
    National Human Genome Research Institute, Bethesda, MD, USA
    Pigment Cell Melanoma Res 22:435-44. 2009
    Microphthalmia-associated transcription factor (MITF) is involved in melanocyte cell development, pigmentation and neoplasia...
  12. ncbi Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus
    N Fuse
    Department of Molecular Biology and Applied Physiology Saitama Cancer Center, Saitama 362 080, Japan
    J Biochem 126:1043-51. 1999
    Microphthalmia-associated transcription factor (MITF) is a basic helix-loop-helix-leucine zipper protein, and plays an important role in the development of various cell types, such as neural-crest-derived melanocytes and optic-cup-derived ..
  13. ncbi Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling
    Ken ichi Yasumoto
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    EMBO J 21:2703-14. 2002
    ..between the basic helix-loop-helix and leucine-zipper region of microphthalmia-associated transcription factor (MITF) and LEF-1...
  14. ncbi Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells
    Jane Goodall
    Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, United Kingdom
    Cancer Res 68:7788-94. 2008
    ..In melanoma and in melanocyte development, the microphthalmia-associated transcription factor (Mitf) controls survival, differentiation, proliferation, and migration/metastasis...
  15. ncbi STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression
    Akiko Joo
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Oncogene 23:726-34. 2004
    ..We found that the microphthalmia-associated transcription factor (MITF), an essential transcription factor for melanocyte development and pigmentation, induces anchorage-independent ..
  16. ncbi Tietz syndrome (hypopigmentation/deafness) caused by mutation of MITF
    S D Smith
    Center for Hereditary Communication Disorders, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA
    J Med Genet 37:446-8. 2000
    ..This family was reascertained and a missense mutation was found in the basic region of the MITF gene in family members with Tietz syndrome...
  17. ncbi Sumoylation of MITF and its related family members TFE3 and TFEB
    Arlo J Miller
    Dana Farber Cancer Institute and Children s Hospital, Department of Pediatric Hematology Oncology, Melanoma Program in Medical Oncology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:146-55. 2005
    b>MITF and its related family members TFE3 and TFEB heterodimerize with each other, recognize the same DNA sequences, and are subject to many of the same post-translational modifications...
  18. ncbi Genomic analysis of the Microphthalmia locus and identification of the MITF-J/Mitf-J isoform
    Christine L Hershey
    Division of Pediatric Hematology Oncology and Melanoma Program in Medical Oncology, Dana Farber Cancer Institute and Children s Hospital, Harvard Medical School, 44 Binney Street, Dana 630, Boston, MA 02115, USA
    Gene 347:73-82. 2005
    ..Waardenburg Syndrome Type 2 is caused by mutations in the human Microphthalmia-associated transcription factor (MITF) gene...
  19. ncbi Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 OTL, UK
    Nature 433:764-9. 2005
    ..The microphthalmia-associated transcription factor Mitf has a crucial but poorly defined role in melanoblast and melanocyte survival and in differentiation...
  20. ncbi Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner
    Hideki Murakami
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Pigment Cell Res 18:265-77. 2005
    The microphthalmia transcription factor MITF plays important roles in several cell lineages including retinal and neural crest-derived pigment cells...
  21. ncbi The melanocyte-specific isoform of the microphthalmia transcription factor affects the phenotype of human melanoma
    Edgar Selzer
    Department of Radiotherapy and Radiobiology, University Hospital Vienna, 1090 Vienna, Austria
    Cancer Res 62:2098-103. 2002
    The microphthalmia transcription factor MITF plays a pivotal role in the development and differentiation of melanocytes...
  22. ncbi Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation
    Claudia Wellbrock
    Signal Transduction Team, Cancer Research UK Centre of Cell and Molecular Biology, The Institute of Cancer Research, London SW3 6JB, England, UK
    J Cell Biol 170:703-8. 2005
    ..Microphthalmia-associated transcription factor (MITF) is an important melanocyte differentiation and survival factor, but its role in melanoma is unclear...
  23. ncbi Microphthalmia-associated transcription factor (MITF): multiplicity in structure, function, and regulation
    S Shibahara
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    J Investig Dermatol Symp Proc 6:99-104. 2001
    Microphthalmia-associated transcription factor (MITF) regulates the differentiation and development of melanocytes and retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme ..
  24. ncbi c-Met expression is regulated by Mitf in the melanocyte lineage
    Gael G McGill
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    J Biol Chem 281:10365-73. 2006
    ..the mechanism by which HGF up-regulates its receptor, we found that c-Met is a direct transcriptional target of Mitf. This was confirmed with chromatin immunoprecipitation experiments of the human c-Met promoter, as well as by the ..
  25. ncbi Microphthalmia transcription factor as a molecular marker for circulating tumor cell detection in blood of melanoma patients
    Kazuo Koyanagi
    Department of Molecular Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Clin Cancer Res 12:1137-43. 2006
    Microphthalmia transcription factor (Mitf), which is important in melanocyte development and melanoma growth, was assessed using real-time quantitative reverse transcription-PCR assay to investigate its expression as a marker for ..
  26. ncbi Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1
    Hideo Saito
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Biol Chem 277:28787-94. 2002
    ..is associated with heterozygous mutations in the gene encoding microphthalmia-associated transcription factor (MITF) and characterized by deafness and hypopigmentation due to lack of melanocytes in the inner ear and skin...
  27. ncbi Evolutionary sequence comparison of the Mitf gene reveals novel conserved domains
    Jón Hallsteinn Hallsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Pigment Cell Res 20:185-200. 2007
    The microphthalmia-associated transcription factor (MITF) is a member of the MYC family of basic helix-loop-helix leucine zipper transcription factors...
  28. ncbi Simultaneous suppression of MITF and BRAF V600E enhanced inhibition of melanoma cell proliferation
    Kenji Kido
    Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku ku, Tokyo
    Cancer Sci 100:1863-9. 2009
    Microphthalmia-associated transcription factor (MITF) is a master gene regulating differentiation of melanocytes, and a lineage survival oncogene mediating pro-proliferative function in malignant melanoma...
  29. ncbi SWI/SNF chromatin remodeling complex is critical for the expression of microphthalmia-associated transcription factor in melanoma cells
    Jiri Vachtenheim
    Laboratory of Molecular Biology, University Hospital, Charles University, Prague, Czech Republic
    Biochem Biophys Res Commun 392:454-9. 2010
    The microphthalmia-associated transcription factor (MITF) is required for melanocyte development, maintenance of the melanocyte-specific transcription, and survival of melanoma cells...
  30. ncbi A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes
    Wade E Huber
    Division of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:45224-30. 2003
    ..of melanocytes via activation of melanocyte-restricted microphthalmia-associated transcription factor (M-MITF) expression...
  31. ncbi Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor gene
    N Fuse
    Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 219:702-7. 1996
    Microphthalmia-associated transcription factor (MITF), the human homolog of the mouse microphthalmia gene product, regulates melanocyte-specific transcription of the tyrosinase gene that codes for an essential enzyme in melanin ..
  32. ncbi MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma
    Jinyan Du
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Harvard Medical School, Boston, USA
    Am J Pathol 163:333-43. 2003
    The clinically important melanoma diagnostic antibodies HMB-45, melan-A, and MITF (D5) recognize gene products of the melanocyte-lineage genes SILV/PMEL17/GP100, MLANA/MART1, and MITF, respectively...
  33. ncbi Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene
    K Yasumoto
    Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Miyagi, Japan
    Mol Cell Biol 14:8058-70. 1994
    ..of a ubiquitous transcription factor, USF, and a novel factor, microphthalmia-associated transcription factor (MITF), recently cloned as the human homolog of the mouse microphthalmia (mi) gene product...
  34. ncbi A gene for Waardenburg syndrome type 2 maps close to the human homologue of the microphthalmia gene at chromosome 3p12-p14.1
    A E Hughes
    Department of Medical Genetics, Belfast City Hospital, UK
    Nat Genet 7:509-12. 1994
    ..05 at zero recombination. Interestingly, the human homologue (MITF) of the mouse microphthalmia gene, a good candidate at the phenotypic level, has recently been mapped to 3p12.3-p14...
  35. ncbi Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium
    S Amae
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Miyagi, Japan
    Biochem Biophys Res Commun 247:710-5. 1998
    Mutations at the mouse locus encoding microphthalmia-associated transcription factor (Mitf) affect the development of many cell types, including retinal pigment epithelium (RPE), melanocytes, mast cells, and osteoclasts...
  36. ncbi Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes
    K Yasumoto
    Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Aoba ku, Sendai, Japan
    J Biol Chem 272:503-9. 1997
    ..a CATGTG motif, which was shown here to be bound in vitro by microphthalmia-associated transcription factor (MITF)...
  37. ncbi MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1
    Feng Liu
    Department of Medicine, Chao Family Comprehensive Cancer Center, Irvine School of Medicine, University of California, Orange, California 92868, USA
    J Invest Dermatol 129:422-31. 2009
    Microphthalmia-associated transcription factor (MiTF) is a key transcription factor for melanocyte lineage survival. Most previous work on this gene has been focused on its role in development...
  38. ncbi MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A
    Amy E Loercher
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 168:35-40. 2005
    ..Here, we show that the master melanocyte differentiation factor, microphthalmia transcription factor (MITF), regulates cell cycle exit by activating the cell cycle inhibitor INK4A, a tumor suppressor that frequently is ..
  39. ncbi Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes
    C Bertolotto
    Institut National de la Sante et de la Recherche Medicale U385, Biologie et Physiopathologie de la Peau, Faculte de Medecine, Paris, France
    J Cell Biol 142:827-35. 1998
    ..These findings disclose the mechanism by which cAMP stimulates tyrosinase expression and melanogenesis and emphasize the critical role of microphthalmia as signal transducer in cAMP-induced melanogenesis and pigment cell differentiation...
  40. ncbi Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
    Gael G McGill
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 109:707-18. 2002
    Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken...
  41. ncbi Transcriptional regulation in melanoma
    Devarati Mitra
    Biology and Biomedical Sciences Program, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Hematol Oncol Clin North Am 23:447-65, viii. 2009
    ..networks of transcriptional activation and repression is microphthalmia-associated transcription factor (MITF), a melanocyte lineage marker that increases pigment production and exhibits diverse effects on cell survival, ..
  42. ncbi Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor
    Miguel F Segura
    Department of Pathology, Interdisciplinary Melanoma Cooperative Group, New York University Medical Center New York, NY 10016, USA
    Proc Natl Acad Sci U S A 106:1814-9. 2009
    ..Our data provide a mechanism for invasion and survival in melanoma that could prove applicable to metastasis of other cancers and suggest that miRNA silencing may be a worthwhile therapeutic strategy...
  43. ncbi Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene
    M Tassabehji
    Department of Medical Genetics, St Mary s Hospital, Manchester, UK
    Nat Genet 8:251-5. 1994
    ..We recently mapped a WS2 gene to chromosome 3p12.3-p14.1 and proposed as a candidate gene MITF, the human homologue of the mouse microphthalmia (mi) gene...
  44. ncbi Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas
    Jasmin N Dynek
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Res 68:3124-32. 2008
    ..Herein, we show that the lineage survival oncogene microphthalmia-associated transcription factor (MITF) is a critical regulator of ML-IAP transcription in melanoma cells...
  45. ncbi The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia-associated transcription factor (MITF) and other melanogenesis-related proteins in normal and pathological skin, hair follicles and melanocytic nevi
    Song Lu
    Division of Dermatology, Albany Medical College MC 81, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Cutan Pathol 37:26-40. 2010
    ..TRPM1 is transcriptionally regulated by the essential melanocyte transcription factor MITF (microphthalmia-associated transcription factor)...
  46. ncbi What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis
    Ana Abad
    Departamento de Inmunologia, Microbiologia y Parasitologia, Facultad de Ciencia y Tecnologia, UPV EHU, Campus de Bizkaia, Leioa, Spain
    Rev Iberoam Micol 27:155-82. 2010
    ..and related genes, such as a diffusible toxic substance from conidia, gliotoxin (gliP and gliZ), mitogillin (res/mitF/asp f 1), hemolysin (aspHS), festuclavine and fumigaclavine A-C, fumitremorgin A-C, verruculogen, fumagillin, ..
  47. ncbi Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature
    Andrew L Folpe
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Surg Pathol 29:1558-75. 2005
    ..S-100 protein, smooth muscle actins (SMA), desmin, vimentin, HMB45, Melan-A, microphthalmia transcription factor (MiTF), TFE3, CD117, and CD34 was performed. Clinical follow-up information was obtained...
  48. ncbi Microphthalmia transcription factor in the immunohistochemical diagnosis of metastatic melanoma: comparison with four other melanoma markers
    M Miettinen
    Armed Forces Institute of Pathology, Department of Soft Tissue Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 25:205-11. 2001
    ..based on the study of a small number of tumors, it was suggested that microphthalmia transcription factor (MITF) is 100% sensitive in the identification of metastatic melanoma...
  49. ncbi Absence of TRP-2 in melanogenic melanocytes of human hair
    Stephane Commo
    L Oréal Recherche Centre de recherche C ZVIAK, Groupe biologie du cheveu, 90 rue du General Roguet, 92583 Clichy Cedex, France
    Pigment Cell Res 17:488-97. 2004
    ..Numerous proteins involved in melanocyte function have been identified including pMel-17, Mitf-M, Sox10, tyrosinase, tyrosinase related proteins-1 (TRP-1) and -2 (TRP-2)...
  50. ncbi Molecular bases of congenital hypopigmentary disorders in humans and oculocutaneous albinism 1 in Japan
    Y Tomita
    Department of Dermatology, Nagoya University School of Medicine, Japan
    Pigment Cell Res 13:130-4. 2000
    ..factor paired box 3 (PAX3) works at the promoter region of the microphthalmia-associated transcription factor (MITF) gene, and the MITF transcription factor orders the expression of c-kit, which encodes the receptor for stem-cell ..
  51. ncbi Expression patterns of MITF during human cutaneous embryogenesis: evidence for bulge epithelial expression and persistence of dermal melanoblasts
    Briana C Gleason
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Cutan Pathol 35:615-22. 2008
    ..The melanocyte master transcriptional regulator, microphthalmia transcription factor (MITF), identifies mature melanocytes as well as melanocyte precursor stem cells that reside in the bulge region of the ..
  52. ncbi Rapid frozen section immunostaining of melanocytes by microphthalmia-associated transcription factor
    L Frank Glass
    Department of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, FL, USA
    Am J Dermatopathol 32:319-25. 2010
    ..article, we report the use of a rapid, 35-minute protocol using microphthalmia-associated transcription factor (MITF) IHC for identifying melanocytes in frozen tissue for its potential use in MMS...
  53. ncbi Kit(+) melanocytes seem to contribute to melanocyte proliferation after UV exposure as precursor cells
    Y Kawaguchi
    Research Laboratories Menard Cosmetic Co, Nishi ku, Nagoya, Japan
    J Invest Dermatol 116:920-5. 2001
    ..0 and 31.7 cells per mm(2), respectively. Only a few Mitf(+) cells and no TRP-2(+) cells were observed...
  54. ncbi Specific expression of Gsta4 in mouse cochlear melanocytes: a novel role for hearing and melanocyte differentiation
    Shigeyuki Uehara
    Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan
    Pigment Cell Melanoma Res 22:111-9. 2009
    ..b>Mitf(mi-bw) is one of the known recessive alleles of the mouse microphthalmia-associated transcription factor (Mitf) ..
  55. ncbi Augmented chemosensitivity in black-eyed white Mitfmi-bw mice, lacking melanocytes
    Kazuhisa Takeda
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Japan
    J Biochem 141:327-33. 2007
    Microphthalmia-associated transcription factor (Mitf) is responsible for differentiation of melanocytes, and a recessive Mitf mutant, black-eyed white (bw) mouse, is characterized by the lack of melanocytes in the skin and inner ear...
  56. ncbi Deficient eosinophil chemotaxis-promoting activity of genetically normal mast cells transplanted into subcutaneous tissue of Mitfmi-vga9/Mitfmi-vga9 mice: comparison of the activity and mast cell distribution pattern with KitW/KitW-vMice
    Keisuke Oboki
    Department of Pathology Room C2, Graduate School of Frontier Bioscience and Medical School, Osaka University, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Am J Pathol 165:1141-50. 2004
    Despite the practical lack of mast cells in the skin tissue of WBB6F(1)-Kit(W)/Kit(W-v), the skin tissue of WBB6F(1)-Mitf(mi-vga9)/Mitf(mi-vga9) mice contains one third of mast cells than that of WBB6F(1)-+/+ mice...
  57. ncbi A dominant negative mutant of microphthalmia transcription factor (MITF) lacking two transactivation domains suppresses transcription mediated by wild type MITF and a hyperactive MITF derivative
    Jiri Vachtenheim
    Laboratory of Molecular Biology, University Hospital, 3rd Medical Faculty, Charles University, Prague, Czech Republic
    Pigment Cell Res 17:43-50. 2004
    Microphthalmia transcription factor (MITF) positively regulates transcription of differentiation-related genes in several cell lineages, including melanocytes...
  58. ncbi Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma
    Liqing Zhuang
    Discipline of Pathology, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia
    Mod Pathol 20:416-26. 2007
    ..was correlated with histopathologic features, clinical progress and expression of transcription factors (AP-2, MITF and p-Stat3). Bcl-2 was expressed in 100% of benign nevi and thin melanoma (<or=1...
  59. ncbi The regulation of miRNA-211 expression and its role in melanoma cell invasiveness
    Joseph Mazar
    Sanford Burnham Medical Research Institute, Orlando, Florida, United States of America
    PLoS ONE 5:e13779. 2010
    ..The transcription factor MITF, important for melanocyte development and function, is needed for high TRPM1 expression...
  60. ncbi Epithelia-mesenchyme interaction plays an essential role in transdifferentiation of retinal pigment epithelium of silver mutant quail: localization of FGF and related molecules and aberrant migration pattern of neural crest cells during eye rudiment forma
    Masasuke Araki
    Developmental Neurobiology Laboratory, Nara Women s University, Nara, 630 8506, Japan
    Dev Biol 244:358-71. 2002
    ..b>Mitf is considered to be the responsible gene and to function similarly to the mouse microphthalmia mutation, and tissue ..
  61. ncbi Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome
    N Bondurand
    Génétique Moléculaire et Physiopathologie, INSERM U468, et Laboratoire de Biochimie et Génétique Moléculaire, AP HP, Hopital Henri Mondor, Creteil Cedex, France
    Hum Mol Genet 9:1907-17. 2000
    ..gene whereas some WS2 cases are associated with mutations in the microphthalmia-associated transcription factor (MITF) gene...
  62. ncbi Retina regeneration in the chick embryo is not induced by spontaneous Mitf downregulation but requires FGF/FGFR/MEK/Erk dependent upregulation of Pax6
    Jason R Spence
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    Mol Vis 13:57-65. 2007
    To elucidate the early cellular events that take place during induction of retina regeneration in the embryonic chick, focusing on the relationship between fibroblast growth factor (FGF) signaling and the regulation of Pax6 and Mitf.
  63. ncbi Pigmented neurofibroma: review of Japanese patients with an analysis of melanogenesis demonstrating coexpression of c-met protooncogene and microphthalmia-associated transcription factor
    Toru Motoi
    Department of Pathology, The University of Tokyo Hospital, Tokyo 113 8655, Japan
    Hum Pathol 36:871-7. 2005
    ..Immunohistochemical examination included known melanogenic markers, microphthalmia-associated transcription factor (MITF), which is a key regulator of melanogenesis, and 2 tyrosine kinase receptors, c-Met and c-Kit, which regulate the ..
  64. ncbi Importance of leucine zipper domain of mi transcription factor (MITF) for differentiation of mast cells demonstrated using mi(ce)/mi(ce) mutant mice of which MITF lacks the zipper domain
    E Morii
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Blood 97:2038-44. 2001
    The mi transcription factor (MITF) is a basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factor that is important for the development of mast cells...
  65. ncbi Levels of retinoic acid and retinaldehyde dehydrogenase expression in eyes of the Mitf-vit mouse model of retinal degeneration
    T Duncan
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Vis 5:9. 1999
    Several reports have characterized the retinal degeneration observed in the Mitf(vit) mutant mouse...
  66. ncbi Expression of tyrosinase and the tyrosinase related proteins in the Mitfvit (vitiligo) mouse eye: implications for the function of the microphthalmia transcription factor
    S B Smith
    Department of Cellular Biology, Medical College of Georgia, Augusta, GA 30912 2000, USA
    Exp Eye Res 66:403-10. 1998
    b>Mitf (Microphthalmia transcription factor), a basic-helix-loop-helix zipper protein, encoded at the microphthalmia (Mitf) locus, regulates the transcription of the gene encoding tyrosinase, the rate-limiting enzyme in melanin biosynthesis,..
  67. ncbi Involvement of transcription factor encoded by the mouse mi locus (MITF) in expression of p75 receptor of nerve growth factor in cultured mast cells of mice
    T Jippo
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Blood 90:2601-8. 1997
    ..of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (hereafter called MITF). Cultured mast cells (CMCs) of mi/mi genotype showed a poor response to nerve growth factor (NGF)...
  68. ncbi Distinct roles for the SgIGSF adhesion molecule and c-kit receptor tyrosine kinase in the interaction between mast cells and the mesentery
    Kenji Watabe
    Department of Pathology, Graduate School of Medicine, Osaka University, Suita 565 0871, Japan
    Biochem Biophys Res Commun 324:782-8. 2004
    ..F1-Sl/Sld [KIT ligand stem cell factor mutant], and F1-tg/tg [a practically microphthalmia transcription factor (MITF)-null mutant] mice...
  69. ncbi Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF
    L Hou
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Development 127:5379-89. 2000
    ..depends on the tyrosine kinase receptor KIT and the basic-helix-loop-helix-leucine zipper transcription factor MITF. KIT and MITF show complex interactions in that MITF is needed for the maintenance of Kit expression in ..
  70. ncbi Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF
    M Nguyen
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Development 127:3581-91. 2000
    ..is associated with the initial coexpression of the basic-helix-loop-helix-zipper transcription factor MITF, which is later needed solely in the pigmented epithelium, and a set of distinct transcription factors that become ..
  71. ncbi Evidence suggesting digenic inheritance of Waardenburg syndrome type II with ocular albinism
    Pei Wen Chiang
    Department of Pediatrics, UC Denver DNA Diagnostic Laboratory, UC Denver School of Medicine, Aurora, Colorado
    Am J Med Genet A 149:2739-44. 2009
    ..In most patients, WS2 results from mutations in the MITF gene...
  72. ncbi The melanocyte inducing factor MITF is stably expressed in cell lines from human clear cell sarcoma
    K K C Li
    Department of Biology, HK University of Science and Technology, Kowloon, HK, China
    Br J Cancer 89:1072-8. 2003
    ..The melanocytic character of CCS suggests that the microphthalmia-associated transcription factor (Mitf), a major inducer of melanocytic differentiation, may be miss-expressed in CCS...
  73. ncbi Role of Mitf in differentiation and transdifferentiation of chicken pigmented epithelial cell
    M Mochii
    Department of Developmental Biology, National Institute for Basic Biology, Okazaki, Japan
    Dev Biol 193:47-62. 1998
    b>Mitf encodes a basic helix-loop-helix-leucine-zipper (bHLHzip) protein that is known to function in the development of melanocytes, pigmented epithelial cells (PECs), osteoclasts, and mast cells...
  74. ncbi Abnormal expression of mouse mast cell protease 5 gene in cultured mast cells derived from mutant mi/mi mice
    E Morii
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Blood 90:3057-66. 1997
    ..of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (hereafter called MITF). The consensus sequence recognized and bound by bHLH-Zip transcription factors is CANNTG...
  75. ncbi The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis
    Francesco Vetrini
    Telethon Institute of Genetics and Medicine TIGEM, Via P Castellino 111, 80131 Naples, Italy
    Mol Cell Biol 24:6550-9. 2004
    ..We demonstrated that Oa1 is a target of Mitf and that this regulatory mechanism is conserved in the human gene...
  76. ncbi Analysis of esterification of retinoids in the retinal pigmented epithelium of the Mitf-vit (vitiligo) mutant mouse
    B L Evans
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912 2000, USA
    Mol Vis 3:11. 1997
    Mice homozygous for the vitiligo mutation of the microphthalmia (Mitf) gene have a retinal degeneration characterized by slow loss of photoreceptor cells and compromised retinal pigment epithelial (RPE) structure and function...
  77. ncbi Additive effect of mouse genetic background and mutation of MITF gene on decrease of skin mast cells
    Eiichi Morii
    Department of Pathology, Medical School Graduate School of Frontier Bioscience, Osaka University, Yamada oka, Suita, Japan
    Blood 101:1344-50. 2003
    The mi transcription factor (MITF) is a basic-helix-loop-helix leucine zipper transcription factor and is encoded by mi locus...
  78. ncbi Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor
    K Opdecamp
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Development 124:2377-86. 1997
    The more than 20 different Mitf mutations in the mouse are all associated with deficiencies in neural crest-derived melanocytes that range from minor functional disturbances with some alleles to complete absence of mature melanocytes with ..
  79. ncbi A novel isoform of microphthalmia-associated transcription factor inhibits IL-8 gene expression in human cervical stromal cells
    Xiang Hong Li
    Division of Reproductive Endocrinology and Urogynecology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9032, USA
    Mol Endocrinol 24:1512-28. 2010
    ..identification of a novel isoform of micropthalmia-associated transcription factor in human cervical stromal cells (MiTF-CX) that is down-regulated 12-fold during cervical ripening and that represses expression of IL-8...
  80. ncbi MITF is necessary for generation of prostaglandin D2 in mouse mast cells
    Eiichi Morii
    Department of Pathology, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    J Biol Chem 279:48923-9. 2004
    ..A basic-helix-loop-helix leucine zipper transcription factor termed MITF is essential for the development of mast cells...
  81. ncbi Number of mast cells in the peritoneal cavity of mice: influence of microphthalmia transcription factor through transcription of newly found mast cell adhesion molecule, spermatogenic immunoglobulin superfamily
    Eiichi Morii
    Department of Pathology, Room C2, Osaka University Medical School, Yamada oka 2 2, Suita 565 0871, Japan
    Am J Pathol 165:491-9. 2004
    The mi (microphthalmia) locus of mice encodes a transcription factor, MITF. B6-tg/tg mice that do not express any MITF have white coats and small eyes...
  82. ncbi HMB-45 and Melan-A are useful in the differential diagnosis between granular cell tumor and malignant melanoma
    Briana C Gleason
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Dermatopathol 29:22-7. 2007
    ..Immunohistochemical stains for S-100 protein, A, HMB-45, and microphthalmia transcription factor (MITF) were performed in all cases. All of the tumors were positive for S-100 protein...
  83. ncbi Expressional changes in the intracellular melanogenesis pathways and their possible role in the pathogenesis of vitiligo
    Külli Kingo
    Department of Dermatology and Venerology, Centre of Molecular and Clinical Medicine, University of Tartu, Tartu, Estonia
    J Dermatol Sci 52:39-46. 2008
    ..In our previous study we established significant increase of melanocortin receptor expression in unaffected skin of vitiligo patients compared to healthy subjects...
  84. ncbi Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression
    Peter Westenskow
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Development 136:2505-10. 2009
    ..The transcription factors microphthalmia-associated transcription factor (Mitf) and orthodenticle homolog 2 (Otx2) are crucial for RPE development and function; however, very little is known ..
  85. ncbi Baicalein inhibits melanogenesis through activation of the ERK signaling pathway
    Xiaohong Li
    Dermatology Department, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, P R China
    Int J Mol Med 25:923-7. 2010
    ..the effect on two protein kinases, ERK and Akt and downstream microphthalmia-associated transcription factor (MITF) were examined by Western blotting and RT-PCR...
  86. ncbi MITF: a stream flowing for pigment cells
    M Tachibana
    Research Institute, Saitama Cancer Center, Ina, Japan
    Pigment Cell Res 13:230-40. 2000
    Microphthalmia-associated transcription factor (MITF) is a transcription factor with a basic-helix-loop-helix-leucine zipper (bHLHZip) structure...
  87. ncbi Duplicate mitf genes in zebrafish: complementary expression and conservation of melanogenic potential
    J A Lister
    Department of Biological Structure, Center for Developmental Biology, University of Washington, HSB G514, Seattle, Washington 98195 7420, USA
    Dev Biol 237:333-44. 2001
    ..Here, we describe a second zebrafish mitf gene, mitfb, which may fulfill this role...
  88. ncbi Altered expression of the iron transporter Nramp1 (Slc11a1) during fetal development of the retinal pigment epithelium in microphthalmia-associated transcription factor Mitf(mi) and Mitf(vitiligo) mouse mutants
    J Gelineau-van Waes
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5455, USA
    Exp Eye Res 86:419-33. 2008
    Microphthalmia-associated transcription factor (Mitf) is expressed in neural crest cell-derived melanocytes, and in the retinal pigment epithelium (RPE) during ocular development...
  89. ncbi Genomic, transcriptional and mutational analysis of the mouse microphthalmia locus
    J H Hallsson
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Genetics 155:291-300. 2000
    ..In humans, MITF mutations cause Waardenburg syndrome type 2A (WS2A) and Tietz syndrome, autosomal dominant disorders resulting in deafness and hypopigmentation...
  90. ncbi "Transcription physiology" of pigment formation in melanocytes: central role of MITF
    Jiri Vachtenheim
    University Hospital, Prague, Czech Republic
    Exp Dermatol 19:617-27. 2010
    ..The genes for melanin synthesis and deposition are coordinately expressed in melanocytes. The transcription factor MITF, which has been reported to activate more than 25 genes in pigment cells, has emerged as an essential regulator not ..
  91. ncbi Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF
    Kapil Bharti
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:1169-78. 2008
    During vertebrate eye development, the transcription factor MITF plays central roles in neuroepithelial domain specification and differentiation of the retinal pigment epithelium...
  92. ncbi MiTF links Erk1/2 kinase and p21 CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells
    Feng Liu
    Department of Medicine, University of California Irvine School of Medicine, Orange, CA 92868, USA
    Mol Cancer 9:214. 2010
    As a survival factor for melanocytes lineage cells, MiTF plays multiple roles in development and melanomagenesis. What role MiTF plays in the DNA damage response is currently unknown...
  93. ncbi Defective co-activator recruitment in osteoclasts from microphthalmia-oak ridge mutant mice
    Sudarshana M Sharma
    Department of Molecular and Cellular Biochemistry, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    J Cell Physiol 220:230-7. 2009
    The three basic DNA-binding domain mutations of the microphthalmia-associated transcription factor (Mitf), Mitf(mi/mi), Mitf(or/or), and Mitf(wh/wh) affect osteoclast differentiation with variable penetrance while completely impairing ..
  94. ncbi Identification of a distal enhancer for the melanocyte-specific promoter of the MITF gene
    Ken ichi Watanabe
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Pigment Cell Res 15:201-11. 2002
    ..WS type 2 is associated with mutations in the gene encoding microphthalmia-associated transcription factor (MITF) that is required for melanocyte differentiation...
  95. ncbi Ovulation defect and its restoration by bone marrow transplantation in osteopetrotic mutant mice of Mitf(mi)/Mitf(mi) genotype
    H Watanabe
    Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Japan
    Biol Reprod 57:1394-400. 1997
    Mutation within the Mitf gene causes, in microphthalmic Mitf(mi)/Mitf(mi) (mi/mi) mice, multiple defects, including white coat color and functional defects in macrophages and osteoclasts...
  96. ncbi Microphthalmia transcription factor analysis in posterior uveal melanomas
    Frederic Mouriaux
    Service d Ophtalmologie, Centre Hopitalier de Lens, route de la Bassee, Lens 62307, France
    Exp Eye Res 76:653-61. 2003
    The protein encoded by the Microphthalmia gene (MITF) is a transcription factor essential for the development and survival of melanocytes. It serves as a master regulator in modulating extracellular signals...
  97. ncbi The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor
    Nicholas A Meadows
    Institute for Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia
    J Biol Chem 282:1891-904. 2007
    Microphthalmia transcription factor (MITF) regulates osteoclast function by controling the expression of genes, including tartrate-resistant acid phosphatase (TRAP) and cathepsin K in response to receptor activator of nuclear factor-..
  98. ncbi Microphthalmia transcription factor: a sensitive and specific marker for malignant melanoma in cytologic specimens
    C C Dorvault
    Department of Pathology, University of Alabama at Birmingham, 35249 6823, USA
    Cancer 93:337-43. 2001
    ..Microphthalmia transcription factor (Mitf) is a nuclear transcription factor critical for the development and survival of melanocytes and has been shown as a ..
  99. ncbi Impaired expression of integrin alpha-4 subunit in cultured mast cells derived from mutant mice of mi/mi genotype
    D K Kim
    Department of Pathology, the Department of Internal Medicine II, The Department of Hematology and Oncology, Osaka University Medical School, Suita, Japan
    Blood 92:1973-80. 1998
    ..a member of the basic-helix-loop-helix-leucine zipper protein family of transcription factors (hereafter called MITF)...
  100. ncbi Differential expression of cathepsin K in neoplasms harboring TFE3 gene fusions
    Guido Martignoni
    Department of Pathology and Diagnostic, University of Verona, Verona, Italy
    Mod Pathol 24:1313-9. 2011
    Cathepsin K is a protease whose expression is driven by microphthalmia transcription factor (MITF) in osteoclasts...
  101. ncbi Characterization of excess hard tissue occurring in the mesio-buccal surface of the mandibular first molar in microphthalmic mouse
    Tadafumi Tomohiro
    Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine, 2 1 3 Tsurumi, Tsurumi ku, Yokohama 230 8501, Japan
    Arch Oral Biol 52:828-35. 2007
    The aim of the present study was to characterize the excess hard tissue on the mandible of the microphthalmic mouse having a mutation at the mitf locus.

Research Grants67

  1. ATF2 in melanoma development and progression
    ZE apos EV A RONAI; Fiscal Year: 2010
    ..Initial analysis of melanocytes identified a set of pigmentation genes, including MITF, MC1R, Silver, DCT and TYRP1, whose expression is altered in the absence of functional ATF2...
  2. Characterization of neural crest stem cells in human hair follicles.
    Xiaowei Xu; Fiscal Year: 2010
    ..We will study the interaction of Wnt3a, stem cell factor and endothelin-3 with Mitf during this process. We expect that bulge hNCSCs retain the pluripotency and function of embryonic NCSCs...
  3. Mi: Modulating Osteoclast Gene Expression and Function
    Michael Ostrowski; Fiscal Year: 2009
    The microphthalmia transcription factor (MITF) is required for terminal differentiation of developmentally unrelated cell types including osteoclasts, mast cells, pigmented retinal epithelial cells and melanocytes and regulates distinct ..
  4. Signaling Pathways for UV-Induced Melanogenic Responses
    Zalfa Abdel Malek; Fiscal Year: 2007
    ..to elucidate whether the survival effects of ET-1 and/or alpha-MSH involve activation of the transcription factor Mitf, which upregulates Bcl2 expression, by modulating the activities of ERK1/2, p38 and JNK/SAPK, and CREB in UVB-..
  5. Mi: Modulating Osteoclast Gene Expression and Function
    Michael C Ostrowski; Fiscal Year: 2010
    The microphthalmia transcription factor (MITF) is required for terminal differentiation of developmentally unrelated cell types including osteoclasts, mast cells, pigmented retinal epithelial cells and melanocytes and regulates distinct ..
  6. Mitf: A Master Gene for Melanocyte Development
    David E Fisher; Fiscal Year: 2010
    b>MITF is a master transcriptional regulator of melanocyte pigmentation as well as lineage survival...
  7. Mitf: A Master Gene for Melanocyte Development
    David Fisher; Fiscal Year: 2007
    b>MITF is a master transcriptional regulator of melanocyte pigmentation as well as lineage survival...
  8. The role of Mc1r in melanocytic UV-induced DNA damage and repair responses
    JOHN A DORAZIO; Fiscal Year: 2010
    ..and by investigating the ability of cAMP-responsive transcription factors downstream of Mc1r signaling (namely Mitf and CREB) to bind to and induce transcription of NER enzyme promoters...
  9. Mitf: A Master Gene for Melanocyte Development
    David E Fisher; Fiscal Year: 2010
    b>MITF is a master transcriptional regulator of melanocyte pigmentation as well as lineage survival...
  10. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2007
    ..it is in its most active form and is able to cooperate with the microphthalmia transcription factor (MITF) to induce melanocytes to differentiate and cease proliferating...
  11. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2009
    ..it is in its most active form and is able to cooperate with the microphthalmia transcription factor (MITF) to induce melanocytes to differentiate and cease proliferating...
  12. Role of TRPM1 (Melastatin1) in the Biology of Human Melanocytes
    Vijayasaradhi Setaluri; Fiscal Year: 2010
    ..Tissue distribution and promoter regulation by microphthalmia transcription factor (MITF) confirmed TRPM1 as a melanocyte-restricted TRP...
  13. Regulation of Melanocyte Differentiation by SWI/SNF Chromatin Remodeling Enzymes
    Ivana L de la Serna; Fiscal Year: 2010
    ..Microphthalmia Transcription Factor (MITF) is the master regulator of melanocyte differentiation and activates the expression of genes important for melanin ..
  14. Molecular signatures of melanoma histology and progression: A Population Based A
    Abrar A Qureshi; Fiscal Year: 2010
    ..by two robust signatures: one broadly defined by a cluster of microphthalmia and melanocyte differentiation genes ("MITF" class) and a more heterogeneous group of inflammation, innate immune, and growth-related genes ("IIG" class)...
  15. Molecular signatures of melanoma histology and progression: A Population Based A
    Abrar Qureshi; Fiscal Year: 2009
    ..by two robust signatures: one broadly defined by a cluster of microphthalmia and melanocyte differentiation genes ("MITF" class) and a more heterogeneous group of inflammation, innate immune, and growth-related genes ("IIG" class)...
  16. Transcriptional Regulation of Melanocyte Development
    Thomas Hornyak; Fiscal Year: 2003
    ..The specific aims of this proposal are to understand the function of the transcription factors Mitf and Pax3 in melanocyte development and to determine how the misexpression of a basic helix-loop-helix transcription ..
  17. Transcriptional Regulation of Melanocyte Development
    FAITH STRICKLAND; Fiscal Year: 2004
    ..The specific aims of this proposal are to understand the function of the transcription factors Mitf and Pax3 in melanocyte development and to determine how the misexpression of a basic helix-loop-helix transcription ..
  18. Developmental Checkpoints of Murine Mast Cells
    Koichi Akashi; Fiscal Year: 2009
    ..1, GATA-2 and MITF, and of neutrophils/monocyte-related transcription factor, C/EBPalpha, in mast cell development...
  19. Molecular Pathway in Retina Regeneration
    Katia Del Rio Tsonis; Fiscal Year: 2004
    ..This study will determine the roles of microphthalmia (Mitf), a rPEC specific transciptional factor, Pax-6 a well known regulator of retina development, as well as the role of ..
  20. Genetic networks that regulate the mast lineage
    Clifford Takemoto; Fiscal Year: 2007
    ..The microphthalmia-associated transcription factor (Mitf) is essential for the development of mast cells; our laboratory has recently cloned and characterized a novel ..
  21. Genetic networks that regulate the mast lineage
    Clifford Takemoto; Fiscal Year: 2009
    ..The microphthalmia-associated transcription factor (Mitf) is essential for the development of mast cells; our laboratory has recently cloned and characterized a novel ..
  22. Mechanisms Controlling RPE Development
    Sabine Fuhrmann; Fiscal Year: 2010
    ..While some genes crucial for RPE development and function (e.g. Mitf, Otx2) are known, it is unclear how RPE-specific gene expression is initiated and maintained...
  23. Transcriptional Regulation of Osteoclasts by Mitf
    Yi Ling Lin; Fiscal Year: 2005
    ..Mice carrying semidominant Mitf alleles exhibit various degrees of osteopetrosis, indicating Mitf is a promising tool for studying gene regulation ..
  24. The MiT Transcription Factor in Pediatric Malignancies
    David Fisher; Fiscal Year: 2007
    ..Another, TFE3, modulates osteoclast development together with Mitf. We recently cloned a recurring translocation in Papillary Renal Cell Carcinoma (PRCC), and identified the MiT ..
  25. Role of TFE3 in Renal Cell Carcinoma
    Christopher Roman; Fiscal Year: 2004
    ..TFE3, a member of the MiT transcription factor family that includes Mitf, the gene mutated in microphthalmia, has been implicated in TGFa, Wnt, and c-kit signaling pathways...
  26. Coloney Stimulating Factor 1 regulation and role in bone
    Karl Insogna; Fiscal Year: 2007
    ..proliferation and differentiation, the latter dependent in part on activation of the transcription factor, Mitf. Recent evidence indicates an important role for CSF1 in states of accelerated bone loss including estrogen-..