MDM4

Summary

Gene Symbol: MDM4
Description: Mdm4 p53 binding protein homolog (mouse)
Alias: HDMX, MDMX, MRP1, MDM4-related protein 1, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein, double minute 4, human homolog of; p53-binding protein, mdm2-like p53-binding protein, protein Mdm4, protein Mdmx
Species: human

Top Publications

  1. ncbi Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
    Erik Meulmeester
    Department of Molecular and Cell Biology, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
    Mol Cell 18:565-76. 2005
  2. ncbi Ribosomal protein S7 is both a regulator and a substrate of MDM2
    Yan Zhu
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Mol Cell 35:316-26. 2009
  3. ncbi ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
    Lihong Chen
    Molecular Oncology Program, H Lee Moffitt Comprehensive Cancer Center and Research Institute, Tampa, FL 33612, USA
    EMBO J 24:3411-22. 2005
  4. ncbi c-Abl phosphorylates Hdmx and regulates its interaction with p53
    Valentina Zuckerman
    Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Biol Chem 284:4031-9. 2009
  5. ncbi Mutual dependence of MDM2 and MDMX in their functional inactivation of p53
    Jijie Gu
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Biol Chem 277:19251-4. 2002
  6. ncbi High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas
    Yasmine A Valentin-Vega
    Department of Cancer Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 38:1553-62. 2007
  7. ncbi Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX
    Baoli Hu
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Cancer Res 67:8810-7. 2007
  8. ncbi Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
    K Linke
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Cell Death Differ 15:841-8. 2008
  9. ncbi HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea
    Genglin Jin
    Department of Pathology, Pediatric Brain Tumor Foundation Institute and Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuro Oncol 12:956-66. 2010
  10. ncbi MDM4 (MDMX) and its Transcript Variants
    F Mancini
    National Council of Research, Institute of Neurobiology and Molecular Medicine, Roma
    Curr Genomics 10:42-50. 2009

Research Grants

  1. Effect of nutritional status on MRP2 expression and biliary excretion of bispheno
    Angela L Slitt; Fiscal Year: 2010
  2. Effect of nutritional status on MRP2 expression and biliary excretion of bispheno
    ANGELA SLITT; Fiscal Year: 2009
  3. Effect of nutritional status on MRP2 expression and biliary excretion of bispheno
    ANGELA SLITT; Fiscal Year: 2009
  4. TRANSPORT CHARACTERISTICS OF PEPTIDE MIMETICS
    RONALD BORCHARDT; Fiscal Year: 2003
  5. Molecular Targeting of Drug Delivery System to Cancer
    Tamara Minko; Fiscal Year: 2010
  6. Molecular Targeting of Drug Delivery System to Cancer
    Tamara Minko; Fiscal Year: 2007
  7. Molecular Targeting of Drug Delivery System to Cancer
    Tamara Minko; Fiscal Year: 2009
  8. MECHANISM OF ATP DEPENDENT TRANSPORT BY MRP1 PROTEIN
    Xiu Bao Chang; Fiscal Year: 2005
  9. Improved Anti-HIV Therapy with P-glycoprotein Inhibitors
    KEVIN FRENCH; Fiscal Year: 2002
  10. Two Photon Imaging of Drug Uptake Efflux & Modulation in MDR Tumor Cells in vivo
    AHMAD SAFA; Fiscal Year: 2007

Detail Information

Publications171 found, 100 shown here

  1. ncbi Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
    Erik Meulmeester
    Department of Molecular and Cell Biology, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
    Mol Cell 18:565-76. 2005
    ..HAUSP also modulates p53 stability indirectly by deubiquitination and stabilization of Hdm2. The Hdmx protein affects p53 stability as well through its interaction with and regulation of Hdm2...
  2. ncbi Ribosomal protein S7 is both a regulator and a substrate of MDM2
    Yan Zhu
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Mol Cell 35:316-26. 2009
    ..Notably, the MDM2 homolog MDMX facilitates the inhibition of MDM2 E3 ligase activity by S7...
  3. ncbi ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
    Lihong Chen
    Molecular Oncology Program, H Lee Moffitt Comprehensive Cancer Center and Research Institute, Tampa, FL 33612, USA
    EMBO J 24:3411-22. 2005
    ..Rapid activation of p53 by ionizing radiation is dependent on signaling by the ATM kinase. MDM2 and MDMX are important p53 regulators and logical targets for stress signals...
  4. ncbi c-Abl phosphorylates Hdmx and regulates its interaction with p53
    Valentina Zuckerman
    Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Biol Chem 284:4031-9. 2009
    ..For this to occur, p53 must be relieved from its major inhibitors, Mdm2 (Hdm2 in humans) and Mdmx (Mdm4; Hdmx in humans)...
  5. ncbi Mutual dependence of MDM2 and MDMX in their functional inactivation of p53
    Jijie Gu
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Biol Chem 277:19251-4. 2002
    b>MDMX, an MDM2-related protein, has emerged as yet another essential negative regulator of p53 tumor suppressor, since loss of MDMX expression results in p53-dependent embryonic lethality in mice...
  6. ncbi High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas
    Yasmine A Valentin-Vega
    Department of Cancer Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 38:1553-62. 2007
    ..A novel p53 inhibitor, MDM4, was more recently identified. The role of MDM4 in cancer development is not well understood...
  7. ncbi Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX
    Baoli Hu
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Cancer Res 67:8810-7. 2007
    The p53 tumor suppressor plays a key role in protection against malignant transformation. MDM2 and MDMX are important regulators of the transcriptional activity and stability of p53 by binding to its NH(2) terminus...
  8. ncbi Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
    K Linke
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Cell Death Differ 15:841-8. 2008
    ..During normal non-stress conditions p53 is targeted for degradation by MDM2. MDM2 can also target itself and MDMX for degradation...
  9. ncbi HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea
    Genglin Jin
    Department of Pathology, Pediatric Brain Tumor Foundation Institute and Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuro Oncol 12:956-66. 2010
    ..Quantitative real-time PCR measurements revealed that HDMX is the most commonly amplified and overexpressed gene in the 1q32 locus...
  10. ncbi MDM4 (MDMX) and its Transcript Variants
    F Mancini
    National Council of Research, Institute of Neurobiology and Molecular Medicine, Roma
    Curr Genomics 10:42-50. 2009
    ..Alterations of their gene status, mainly amplification events, have been frequently observed in human tumors.MDM4 is one of the two members of the MDM family...
  11. ncbi Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7
    Feroz Sarkari
    Department of Molecular Genetics, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    J Mol Biol 402:825-37. 2010
    ..The ability of USP7 to also deubiquitinate and control the turnover of HdmX was recently demonstrated...
  12. ncbi MdmX inhibits ARF mediated Mdm2 sumoylation
    Mithua Ghosh
    Department of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio 45435, USA
    Cell Cycle 4:604-8. 2005
    ..In this present work, we report that MdmX can undergo ARF-mediated sumoylation similar to that reported for Mdm2...
  13. ncbi Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage
    Yaron Pereg
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Proc Natl Acad Sci U S A 102:5056-61. 2005
    ..Here we show that efficient damage-induced degradation of human Hdmx depends on functional ATM and at least three sites on the Hdmx that are phosphorylated in response to DSBs...
  14. ncbi Regulation of p53-MDMX interaction by casein kinase 1 alpha
    Lihong Chen
    H Lee Moffitt Cancer Center, MRC3057A, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cell Biol 25:6509-20. 2005
    b>MDMX is a homolog of MDM2 that is critical for regulating p53 function during mouse development. MDMX degradation is regulated by MDM2-mediated ubiquitination. Whether there are other mechanisms of MDMX regulation is largely unknown...
  15. ncbi Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis
    Frank Bartel
    Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, Halle Saale, Germany
    Int J Cancer 117:469-75. 2005
    The product of the HDMX (or MDM4) gene is structurally related to the MDM2 oncoprotein and is also capable of interacting with the tumor suppressor protein p53...
  16. ncbi Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity
    Davide Danovi
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    Mol Cell Biol 24:5835-43. 2004
    ..Furthermore, the human Mdmx ortholog, Hdmx, was found to be overexpressed in a significant percentage of various human tumors and amplified in 5% of primary ..
  17. ncbi MdmX represses E2F1 transactivation
    Mark Wunderlich
    Wright State University, Department of Biochemistry and Molecular Biology, Dayton, Ohio 45435, USA
    Cell Cycle 3:472-8. 2004
    Based on knockout mouse studies, Mdm2 and MdmX have been identified as critical regulators of the p53 tumor suppressor protein, at least during early development...
  18. ncbi DNA damage-induced MDMX degradation is mediated by MDM2
    Hidehiko Kawai
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Biol Chem 278:45946-53. 2003
    Although genetic studies have demonstrated that MDMX is essential to maintain p53 activity at low levels in non-stressed cells, it is unknown whether MDMX regulates p53 activation by DNA damage...
  19. ncbi MDM2 promotes ubiquitination and degradation of MDMX
    Yu Pan
    Molecular Oncology Program, H Lee Moffitt Comprehensive Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cell Biol 23:5113-21. 2003
    ..Recent studies showed that the MDM2 homolog MDMX is also an important regulator of p53...
  20. ncbi The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein
    Gordon D Strachan
    Department of Pathology, University of Pennsylvania School of Dental Medicine, 4010 Locust St, Rm 312 Levy Research, Philadelphia 19104 6002, USA
    J Cell Biochem 88:557-68. 2003
    ..Here we identify the MDMX oncoprotein as an E2F-1-binding factor, from a yeast-two hybrid screen using a portion of the E2F-1 protein as &..
  21. ncbi Targeting the conformational transitions of MDM2 and MDMX: insights into dissimilarities and similarities of p53 recognition
    Antonio Macchiarulo
    Dipartimento di Chimica e Tecnologia del Farmaco, Universita di Perugia, Via del Liceo 1, Perugia, Italy
    J Chem Inf Model 48:1999-2009. 2008
    MDM2 and MDMX are oncogenic homologue proteins that regulate the activity and stability of p53, a tumor suppressor protein involved in more than 50% of human cancers...
  22. ncbi ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation
    Erik Meulmeester
    Department of Molecular and Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Cell Cycle 4:1166-70. 2005
    The p53 tumor suppressor protein has a major role in protecting genome integrity. Under normal circumstances Mdmx and Mdm2 control the activity of p53...
  23. ncbi Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization
    Simona Giglio
    Laboratory of Molecular Oncogenesis, Regina Elena Cancer Institute
    Cancer Res 65:9687-94. 2005
    The HDMX protein is closely related to HDM2 with which it shares different structural domains, particularly the p53 binding domain and the ring finger domain, where the two HDM proteins interact...
  24. ncbi Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding
    Vanessa Lopez-Pajares
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Biol Chem 283:13707-13. 2008
    ..We have shown previously that the MDM2-MDMX complex functions as an integral unit in targeting p53 for degradation...
  25. ncbi Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene
    Gurinder Singh Atwal
    The Ludwig Institute for Cancer Research, University of Oxford, Oxford, United Kingdom
    Proc Natl Acad Sci U S A 106:10236-41. 2009
    ..In this report, we analyze the haplotype structure of MDM4, a structural homolog of MDM2, in several different human populations...
  26. ncbi RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity
    Hidehiko Kawai
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 67:6026-30. 2007
    ..domain of MDM2 that is essential for its E3 ligase activity mediates binding to itself and its structural homologue MDMX. Whereas it has been reported that RING domain interactions are critical, it is not well understood how they affect ..
  27. ncbi Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2
    Rajesh K Singh
    Department of Biology, University of Konstanz, 78457 Konstanz, Germany
    J Biol Chem 282:10901-7. 2007
    ..Mdm2 can bind to itself and to the structurally related protein MdmX, and these interactions involve the RING finger domain of Mdm2 and MdmX, respectively...
  28. ncbi A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer
    Diptee A Kulkarni
    Department of Medicine Division of Medical Oncology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Carcinogenesis 30:1910-5. 2009
    Murine double minute 4 (MDM4) shares significant structural homology with murine double minute 2 (MDM2) and interacts and regulates transcriptional activity of the tumor suppressor p53...
  29. ncbi An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
    Stjepan Uldrijan
    The Beatson Institute for Cancer Research, Glasgow, UK
    EMBO J 26:102-12. 2007
    ..of the C-terminal tail correlated with a failure of these mutants to oligomerize with MDM2, or with the related protein MDMX (HDMX)...
  30. ncbi Inactivation of the p53 pathway in retinoblastoma
    Nikia A Laurie
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 444:61-6. 2006
    ..In contrast to this prevailing theory, here we show that the tumour surveillance pathway mediated by Arf, MDM2, MDMX and p53 is activated after loss of RB1 during retinogenesis...
  31. ncbi Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4
    Dawn S Chandler
    Center for Childhood Cancer, Columbus Children s Research Institute and Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Cancer Res 66:9502-8. 2006
    ..The murine double-minute protein MDM2 and its homologue MDM4 (also known as MDMX) are critical regulators of p53...
  32. ncbi Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage
    Yaron Pereg
    Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Cell Biol 26:6819-31. 2006
    ..posttranslational modifications on p53 itself, as well as phosphorylation of p53's essential inhibitors, Hdm2 and Hdmx. Recently we showed that ATM- and Hdm2-dependent ubiquitination and subsequent degradation of Hdmx following DSB ..
  33. ncbi 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation
    Yetao Jin
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239, USA
    EMBO J 25:1207-18. 2006
    It has been shown that MDMX inhibits the activity of the tumor suppressor p53 by primarily cooperating with the p53 feedback regulator MDM2. Here, our study shows that this inhibition can be overcome by 14-3-3gamma and Chk1...
  34. ncbi Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
    Cynthia LeBron
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    EMBO J 25:1196-206. 2006
    The MDM2 homolog MDMX is an important regulator of p53 during mouse embryonic development. DNA damage promotes MDMX phosphorylation, nuclear translocation, and degradation by MDM2...
  35. ncbi Effects of MdmX on Mdm2-mediated downregulation of pRB
    Chiharu Uchida
    Department of Biochemistry 1, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    FEBS Lett 580:1753-8. 2006
    ..In the present study, we assessed the effects of MdmX, a structural homolog of Mdm2, on the Mdm2-mediated ubiquitination of pRB...
  36. ncbi MdmX inhibits Smad transactivation
    Madhavi Kadakia
    Department of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio, USA
    Oncogene 21:8776-85. 2002
    ..Our goal in this study was to examine whether overexpression of Mdm2 or MdmX, a Mdm2-related protein, could affect Smad-induced transactivation...
  37. ncbi Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
    Domenico Migliorini
    Department of Experimental Oncology, European Institute of Oncology, 435 Via Ripamonti, 20141 Milan, Italy
    Mol Cell Biol 22:5527-38. 2002
    We report here the characterization of a mutant mouse line with a specific gene trap event in the Mdm4 locus. Absence of Mdm4 expression results in embryonic lethality (10...
  38. ncbi MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts
    Francesca Gentiletti
    Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Oncogene 21:867-77. 2002
    b>MDMX is a p53 binding protein, which shares a high degree of homology with MDM2, a negative regulator of the tumor suppressor p53. MDMX has been shown to counteract MDM2-dependent p53 degradation and to stabilize p53 in its inactive form...
  39. ncbi Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
    J Parant
    The University of Texas M D Anderson Cancer Center, Department of Molecular Genetics, Section of Cancer Genetics, Box 11, 1515 Holcombe Blvd, Houston, Texas, USA
    Nat Genet 29:92-5. 2001
    ..The recently discovered MDM2-related protein MDM4 (also known as MDMX) has some of the same properties as MDM2...
  40. ncbi MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2
    Yetao Jin
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Dr, MS4053, Indianapolis, IN 46202, USA
    Mol Cell Biol 28:1218-29. 2008
    ..Here we report that the MDM2 analog, MDMX, also displays a similar activity. MDMX directly bound to p21 and mediated its proteasomal degradation...
  41. ncbi MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation
    M W Jackson
    Department of Oncology Pathology, Cancer Center Karolinska, Karolinska Institutet and Hospital, S 171 76 Stockholm, Sweden
    J Biol Chem 276:25336-41. 2001
    ..The primary regulator of p53 protein stability is the Mdm2 protein. ARF and MdmX are two proteins that have recently been shown to inhibit Mdm2-mediated degradation of p53 via distinct ..
  42. ncbi MDM2 and MDMX can interact differently with ARF and members of the p53 family
    X Wang
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, China
    FEBS Lett 490:202-8. 2001
    ..and selectivity of different members of the p53 family (p53, p63, and p73) and the MDM2 family (MDM2 and MDMX)...
  43. ncbi MDMX: a novel p53-binding protein with some functional properties of MDM2
    A Shvarts
    Laboratory of Molecular Carcinogenesis, Sylvius Laboratories, Leiden University, The Netherlands
    EMBO J 15:5349-57. 1996
    Here we report the isolation of a cDNA encoding a new p53-associating protein. This new protein has been called MDMX on the basis of its structural similarity to MDM2, which is especially notable in the p53-binding domain...
  44. ncbi MDM2 and MDMX bind and stabilize the p53-related protein p73
    W M Ongkeko
    Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, UK
    Curr Biol 9:829-32. 1999
    ..Like MDM2, the MDM2-related protein MDMX also bound p73 and stabilized the level of p73...
  45. ncbi Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties
    Andrea Prodosmo
    Lab Molecular Oncogenesis, Regina Elena Cancer Institute, Rome, Italy
    J Mol Med (Berl) 86:585-96. 2008
    ..A new p53 regulator, MDM4 (a.k.a. MDMX or HDMX) an analog of MDM2, represents a new oncogene although its impact on tumor properties remains largely unexplored...
  46. ncbi Phosphorylation of MdmX by CDK2/Cdc2(p34) is required for nuclear export of Mdm2
    Bertha Elias
    Department of Oncological Sciences, Cancer Center, Mount Sinai School of Medicine, One Gustive L Levy Place, Box 1130, New York, NY 10029, USA
    Oncogene 24:2574-9. 2005
    Mdm2 and MdmX function as cellular regulators of the p53 tumor suppressor protein...
  47. ncbi Modification of MDMX by sumoylation
    Yu Pan
    Molecular Oncology Program, H Lee Moffitt Comprehensive Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Biochem Biophys Res Commun 332:702-9. 2005
    b>MDMX is a homolog of MDM2 and is critical for regulating p53 function during mouse development...
  48. ncbi MDMX regulation of p53 response to ribosomal stress
    Daniele M Gilkes
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    EMBO J 25:5614-25. 2006
    ..We found that p53 activation by ribosomal stress requires degradation of MDMX in an MDM2-dependent fashion...
  49. ncbi DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation
    Koji Okamoto
    Radiobiology Division, National Cancer Center Research Institute, Tsukiji 5 1 1, Chuo Ku, Tokyo 104 0045, Japan
    Mol Cell Biol 25:9608-20. 2005
    ..Genetic data indicate that Mdmx as well as Mdm2 plays a major role in maintaining p53 activity at low levels in nonstressed cells...
  50. ncbi Regulation of MDMX expression by mitogenic signaling
    Daniele M Gilkes
    H Lee Moffitt Cancer Center, MRC3057A, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cell Biol 28:1999-2010. 2008
    b>MDMX is an important regulator of p53 transcriptional activity and stress response. MDMX overexpression and gene amplification are implicated in p53 inactivation and tumor development...
  51. ncbi MDMX inhibits the p300/CBP-mediated acetylation of p53
    Peter Sabbatini
    Research Institute, University of California, School of Medicine, San Francisco, California 94080, USA
    DNA Cell Biol 21:519-25. 2002
    ..b>MDMX is an MDM2-like protein that shares with MDM2 the ability to interact with p53 and, in turn, inhibit p53-mediated ..
  52. ncbi Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
    D A Sharp
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6069, USA
    J Biol Chem 274:38189-96. 1999
    ..Here we report that MDM2 physically interacts with a structurally related protein termed MDMX. The results obtained in these studies provide evidence that C-terminal RING finger domains, contained within both ..
  53. ncbi MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis
    Francesca Mancini
    Laboratory of Molecular Oncogenesis, Regina Elena Cancer Institute, Via delle Messi d Oro 156, Rome 00158, Italy
    J Biol Chem 279:8169-80. 2004
    Rescue of embryonic lethality in MDM4(-/-) mice through concomitant loss of p53 has revealed a functional partnership between the two proteins...
  54. ncbi DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms
    Changgong Li
    Molecular Oncology Program, H Lee Moffitt Comprehensive Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Mol Cell Biol 22:7562-71. 2002
    The MDM2 homolog MDMX is an important regulator of p53 activity during embryonic development. MDMX inactivation in mice results in embryonic lethality in a p53-dependent fashion...
  55. ncbi MDM2 interacts with MDMX through their RING finger domains
    S Tanimura
    Institute of Life Sciences, Kurume University, Japan
    FEBS Lett 447:5-9. 1999
    ..b>MDMX is structurally related to MDM2 and also binds to p53. However, the function of MDMX has not been clarified yet...
  56. ncbi P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals
    E R Meaden
    Department of Pharmacology and Therapeutics, University of Liverpool, Pharmacology Research Laboratories, 70 Pembroke Place, Liverpool, UK
    J Antimicrob Chemother 50:583-8. 2002
    ....
  57. ncbi Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells
    Jelmer J van Zanden
    Division of Toxicology, Wageningen University, PO Box 8000, 6700 EA, Wageningen, The Netherlands
    Biochem Pharmacol 67:1607-17. 2004
    ..the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump (MRP1 and MRP2) activity by structurally related flavonoids, in GSTP1-1 transfected MCF7 cells (pMTG5)...
  58. ncbi The synthesis and characterization of cellular membrane affinity chromatography columns for the study of human multidrug resistant proteins MRP1, MRP2 and human breast cancer resistant protein BCRP using membranes obtained from Spodoptera frugiperda (Sf9)
    Prateek A Bhatia
    National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, MD 21224 6825, USA
    Talanta 81:1477-81. 2010
    ..membrane affinity chromatography columns) have been developed for the study of the human multidrug transporters MRP1, MRP2 and the breast cancer resistance protein (BCRP)...
  59. ncbi Novel bicistronic retroviral vector expressing gamma-glutamylcysteine synthetase and the multidrug resistance protein 1 (MRP1) protects cells from MRP1-effluxed drugs and alkylating agents
    G Rappa
    Department of Tumor Biology, Norwegian Radium Hospital, Montebello, Oslo 0310, Norway
    Hum Gene Ther 12:1785-96. 2001
    We have constructed two retroviral vectors, one expressing multidrug resistance protein 1 (MRP1) alone (SF91MRP) and the other expressing MRP1 and gamma-glutamylcysteine synthetase (gamma-GCS), the rate-limiting enzyme of glutathione ..
  60. ncbi Modulators of multidrug resistance associated proteins in the management of anticancer and antimicrobial drug resistance and the treatment of inflammatory diseases
    An Kui Yang
    Department of Head and Neck Surgery, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Curr Top Med Chem 10:1732-56. 2010
    Human multidrug resistance protein (MRP/ABCC) family contains 9 members (MRP1-9) which transport a structurally diverse array of anticancer and antimicrobial drugs and several important endogenous substances including prostaglandins (PGs) ..
  61. ncbi Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Mol Cell Biochem 296:85-95. 2007
    ..P-glycoprotein (P-gp or ABCB1), mitoxantrone resistance protein (MXR or ABCG2) and multidrug resistance protein 1 (MRP1 or ABCC1) was investigated, to assess whether an ultimate metabolite form of curcuminoids (THC) is able to modulate ..
  62. ncbi Functional expression of P-glycoprotein and multidrug resistance-associated protein (Mrp1) in primary cultures of rat astrocytes
    X Declèves
    INSERM U26, Hopital Fernand Widal, Paris, France
    J Neurosci Res 60:594-601. 2000
    ..The aim of this study was to compare the expression of P-gp and of multidrug resistance-associated protein (Mrp1), another drug efflux pump, in cultured neonatal rat brain astrocytes and in cultured brain capillary endothelial ..
  63. ncbi [Interaction of WAVE1 and genes involved in multiple drug resistance in children with acute myeloblastic leukemia]
    Ming Hua Yang
    Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhonghua Er Ke Za Zhi 48:175-9. 2010
    ..Expression and/or activity of P-glycoprotein (P-gp), multiple resistance-associated protein-1 (MRP1), lung-resistance related protein (LRP) and breast cancer resistance protein (BCRP) have been considered to be ..
  64. ncbi Simultaneous activity of MRP1 and Pgp is correlated with in vitro resistance to daunorubicin and with in vivo resistance in adult acute myeloid leukemia
    O Legrand
    Universite Paris 6, Formation de Recherche Claude Bernard, E 9912 INSERM, and Service d Hématologie, Hopital Hotel Dieu, Paris, France
    Blood 94:1046-56. 1999
    In adult acute myeloid leukemia (AML), the weight of the contribution of the combined activity of Pgp and MRP1 to drug resistance is not known...
  65. ncbi MRP1/GS-X pump ATPase expression: is this the explanation for the cytoprotection of the heart against oxidative stress-induced redox imbalance in comparison to skeletal muscle cells?
    Mauricio S Krause
    Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Cell Biochem Funct 25:23-32. 2007
    ..Since MRP1 gene product (a GS-X pump ATPase) is a physiological GSSG transporter, adult Wistar rats were tested for MRP1 ..
  66. ncbi Homocamptothecin-daunorubicin association overcomes multidrug-resistance in breast cancer MCF7 cells
    David Chauvier
    Unite MeDIAN, CNRS FRE2141, UFR Pharmacie, IFR53, Reims, France
    Breast Cancer Res Treat 73:113-25. 2002
    ..However, its cytotoxicity was altered by MRP1, but not Pgp, in naturally MRP1-expressing HT29 cells, and etoposide- and doxorubicin-resistant MCF7/VP and MCF7/..
  67. ncbi Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces
    Silvia Gazzin
    INSERM U842, Universite de Lyon, Lyon 1, Faculte de Medecine Laennec, F 69372 Lyon, France
    J Comp Neurol 510:497-507. 2008
    ..ABCb1 (Pgp) and ABCc1 (Mrp1) transporters are two major proteins of neuroprotection whose localization and functional significance at both ..
  68. ncbi Functional expression of the multidrug resistance protein 1 in microglia
    Shannon Dallas
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Ontario, Canada
    J Pharmacol Exp Ther 307:282-90. 2003
    ..Because microglia are the primary brain cells infected by the human immunodeficiency virus type 1 (HIV-1), MRP1 expression within microglia may contribute to lower brain accumulation of anti-HIV drugs...
  69. ncbi Resistance to mitoxantrone in multidrug-resistant MCF7 breast cancer cells: evaluation of mitoxantrone transport and the role of multidrug resistance protein family proteins
    S K Diah
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Res 61:5461-7. 2001
    ..The resistant cell line, MCF7/VP, expresses high levels of MRP1, whereas the parental cell line, MCF7/WT, does not...
  70. ncbi Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes
    Omar Janneh
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, CO, Londonderry BT52 1SA, UK
    J Antimicrob Chemother 60:987-93. 2007
    ..activity of drug efflux transporters, such as P-glycoprotein (P-gp) and multidrug resistance-associated proteins (MRP1/MRP2), may limit intracellular drug accumulation...
  71. ncbi Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells
    C S Morrow
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 273:20114-20. 1998
    To examine the role of multidrug resistance protein 1 (MRP1) and glutathione S-transferases (GSTs) in cellular resistance to antineoplastic drugs, derivatives of MCF7 breast carcinoma cells were developed that express MRP1 in combination ..
  72. ncbi Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines
    D W Zhang
    Cancer Research Laboratories and Department of Pathology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 276:13231-9. 2001
    Murine multidrug resistance protein 1 (mrp1), unlike human MRP1, does not confer resistance to anthracyclines...
  73. ncbi Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1)
    Kazuma Maeno
    Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Kingston, ON, Canada K7L 3N6
    Drug Metab Dispos 37:1411-20. 2009
    Multidrug resistance protein 1 (MRP1) confers drug resistance and also mediates cellular efflux of many organic anions...
  74. ncbi Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity
    Anass Haimeur
    Cancer Research Laboratories, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 277:41326-33. 2002
    The multidrug resistance protein, MRP1 (ABCC1), is an ATP-binding cassette transporter that confers resistance to chemotherapeutic agents...
  75. ncbi In vitro and in vivo downregulation of MRP1 by antisense oligonucleotides: a potential role in neuroblastoma therapy
    Bryone J Kuss
    Institute of Child Health, University College London, London, United Kingdom
    Int J Cancer 98:128-33. 2002
    The expression of MRP1 (multidrug resistance protein-1) is associated with chemoresistance and poor prognosis in neuroblastoma...
  76. ncbi Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens development
    Jenny C Geatrell
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, Wales CF24 3LU, UK
    Exp Eye Res 88:1137-51. 2009
    ..blotting confirmed developmentally regulated expression of Axl and Mcl-1 during mouse lens development and of Mdm2, Mdm4/X and p53 during mouse and chick lens development...
  77. ncbi Photo-activation of the hydrophobic probe iodonaphthylazide in cells alters membrane protein function leading to cell death
    Mathias Viard
    Nanobiology Program, Center of Cancer Research, National Cancer Institute, Frederick, Maryland, USA
    BMC Cell Biol 10:21. 2009
    ..of INA in various cell lines, including those over-expressing the multi-drug resistance transporters MRP1 or Pgp, leads to cell death. We analyzed mechanisms of cell killing by INA-UV treatment...
  78. ncbi Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function
    Isabelle J Létourneau
    Department of Pharmacology and Toxicology, Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Drug Metab Dispos 35:1372-9. 2007
    The ATP-binding cassette multidrug resistance protein 1 MRP1 (ABCC1) mediates the cellular efflux of organic anions including conjugated metabolites, chemotherapeutic agents, and toxicants...
  79. ncbi Mrp1 localization and function in cardiac mitochondria after doxorubicin
    Paiboon Jungsuwadee
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 0305, USA
    Mol Pharmacol 75:1117-26. 2009
    Multidrug resistance-associated protein 1 (Mrp1; Abcc1) is expressed in sarcolemma of murine heart, where it probably protects the cardiomyocyte by mediating efflux of endo- and xenobiotics...
  80. ncbi Expression of proteins associated with therapy resistance in rhabdomyosarcoma and neuroblastoma tumour cells
    Anna Pituch-Noworolska
    Department of Clinical Immunology, Polish American Institute of Paediatrics, Jagiellonian University Medical College, ul Wielicka 265, 30 663 Krakow
    Pol J Pathol 60:168-73. 2009
    ..The immunohistochemical staining for p-gp (p-glycoprotein), MRP1 (multidrug resistance associated protein 1), BCRP (breast cancer resistance protein) and LRP (lung resistance ..
  81. ncbi The use of Tris-lipidation to modify drug cytotoxicity in multidrug resistant cells expressing P-glycoprotein or MRP1
    Ross A Davey
    Bill Walsh Cancer Research Laboratories, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Br J Pharmacol 137:1280-6. 2002
    ..a substrate for an ATP-dependent transporter such as P-glycoprotein or the multidrug resistance-associated protein (MRP1), which are involved in cellular efflux of drugs...
  82. ncbi Identification of domains participating in the substrate specificity and subcellular localization of the multidrug resistance proteins MRP1 and MRP2
    Toshikazu Konno
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 278:22908-17. 2003
    The human multidrug resistance protein MRP1 and its homolog, MRP2, are both thought to be involved in cancer drug resistance and the transport of a wide variety of organic anions, including the cysteinyl leukotriene C4 (LTC4) (Km = 0...
  83. ncbi Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione
    K Barnouin
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Br J Cancer 77:201-9. 1998
    The human multidrug resistance protein (MRP1) confers resistance of cells to a number of different cytostatic drugs and functions as an export pump for glutathione S-conjugates, glucuronides and other amphiphilic anions...
  84. ncbi Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: transporter specificity and structure-activity relationship
    Kazuhiro Katayama
    Department of Chemotherapy, Kyoritsu University of Pharmacy, Tokyo, 105 8512, Japan
    Cancer Chemother Pharmacol 60:789-97. 2007
    ..such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and multidrug resistance-related protein 1 (MRP1), confer resistance to various anticancer agents...
  85. ncbi Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells
    Shigeru Tatebe
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Biochem Biophys Res Commun 290:1427-33. 2002
    ..In this study, we reported that among the six members of the multidrug resistance protein gene (MRP1 to MRP6) family which encode membrane transporters for a diverse group of antitumor agents, expression of MRP1 and ..
  86. ncbi [Reversing multidrug resistance of epidermoid carcinoma drug-resistant cell line KB-MRP1 by tetrandrine]
    Xiao Song Chen
    Department of Respiratory Medicine, Affiliated Provincial Hospital, Anhui Medical University, Hefei, Anhui, 230001, PR China
    Ai Zheng 26:846-50. 2007
    ..This study was to investigate the reversal effect of tetrandrine on multidrug resistance of human epidermoid carcinoma cell line KB-MRP1.
  87. ncbi ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transport
    Runying Yang
    Mayo Foundation, S C Johnson Medical Research Center, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 278:30764-71. 2003
    Multidrug resistance-associated protein (MRP1) transports solutes in an ATP dependent manner by utilizing its two nonequivalent nucleotide binding domains (NBDs) to bind and hydrolyze ATP. The two NBDs possess different properties (Gao, M...
  88. ncbi The leucotriene C4 binding sites in multidrug resistance protein 1 (ABCC1) include the first membrane multiple spanning domain
    Joel Karwatsky
    Institute of Parasitology and Department of Biochemistry, McGill University, Ste Anne de Bellevue, Quebec H9X 3V9, Canada
    Biochemistry 44:340-51. 2005
    The multiple drug resistance protein 1 (MRP1 or ABCC1) transports anticancer drugs and normal cell metabolites. Leucotriene C(4) (LTC(4)) is one of the highest affinity substrates of MRP1...
  89. ncbi P-glycoprotein and multidrug resistance associated protein-1 activity in 132 acute myeloid leukemias according to FAB subtypes and cytogenetics risk groups
    Ollivier Legrand
    Laboratoire E 03 55 INSERM, EA 1529, Universite Paris VI, France
    Haematologica 89:34-41. 2004
    We studied the function of both Pgp and MRP1 to identify subgroups of patients who could benefit from Pgp reversion, and to clarify in different FAB subtypes and in cytogenetic risk groups their expression and function.
  90. ncbi Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 Amsterdam, The Netherlands
    Neuroscience 118:417-29. 2003
    ..of the multidrug resistance gene 1 encoded P-glycoprotein (P-gp) and the multidrug resistance-associated protein 1 (MRP1) by immunocytochemistry...
  91. ncbi Indoloquinoxaline compounds that selectively antagonize P-glycoprotein
    C D Smith
    Department of Pharmacology, Pennsylvania State University, Hershey 17033, USA
    Oncol Res 12:219-29. 2000
    ..The pharmacologies of the two best-studied transporters, P-glycoprotein (Pgp) and MRP1, are partially overlapping but distinct...
  92. ncbi [Expression of proteins associated with multidrug resistance and resistance to chemotherapy in lung cancer]
    Alfredo Paredes Lario
    Servicio de Oncologia, Hospital Donostia, San Sebastian, Guipuzcoa, Espana
    Arch Bronconeumol 43:479-84. 2007
    ..Membrane transporters are proteins that play a crucial role in resistance to chemotherapy. The aim of this study was to assess the influence of membrane transporter protein expression on chemotherapeutic response...
  93. ncbi Role of the Multidrug Resistance Protein 1 in protection from heavy metal oxyanions: investigations in vitro and in MRP1-deficient mice
    Aurelio Lorico
    Department of Tumor Biology, Norwegian Radium Hospital, Montebello, 0310, Norway
    Biochem Biophys Res Commun 291:617-22. 2002
    The Multidrug Resistance Protein 1 (MRP1) is a membrane pump that mediates the efflux of a wide variety of xenobiotics, including arsenical and antimonial compounds, as demonstrated by the study of MRP1-transfected cell lines...
  94. ncbi Human T cell cytokine responses are dependent on multidrug resistance protein-1
    Jinsong Zhang
    Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892 4555, USA
    Int Immunol 18:485-93. 2006
    Multidrug resistance protein-1 (MRP1) belongs to subfamily C of the ATP-binding cassette transporters, and exports leukotriene C(4) and organic anions including the fluorescent calcium indicator indo-1...
  95. ncbi CFTR, MDR1, and MRP1 immunolocalization in normal human nasal respiratory mucosa
    M A Wioland
    Service d Histologie Biologie Tumorale, Universite Pierre et Marie Curie, Paris VI, Hopital Tenon, France
    J Histochem Cytochem 48:1215-22. 2000
    CFTR (cystic fibrosis transmembrane conductance regulator), MDR1 (multidrug resistance), and MRP1 (multidrug resistance-associated protein), members of the ABC transporter superfamily, possess multiple functions, particularly Cl(-), anion,..
  96. ncbi Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin
    Heleen M Wortelboer
    TNO Nutrition and Food Research, P O Box 360, 3700 AJ Zeist, The Netherlands
    Chem Res Toxicol 16:1642-51. 2003
    The multidrug resistance proteins MRP1 and MRP2 are efflux transporters with broad substrate specificity, including glutathione, glucuronide, and sulfate conjugates...
  97. ncbi Role of GSH in estrone sulfate binding and translocation by the multidrug resistance protein 1 (MRP1/ABCC1)
    Alice Rothnie
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 281:13906-14. 2006
    Multidrug resistance protein 1 (MRP1/ABCC1) is an ATP-dependent efflux pump that can confer resistance to multiple anticancer drugs and transport conjugated organic anions...
  98. ncbi Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1
    D J A de Groot
    Department of Medical Oncology, University of Groningen and University Medical Center, PO Box 30 001, 9700 RB, Groningen, The Netherlands
    Br J Cancer 97:1077-83. 2007
    ..The non-steroidal anti-inflammatory drug indomethacin is an inhibitor of multidrug resistance protein 1 (MRP1) function...
  99. ncbi Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3)
    Anne Lespine
    Laboratoire de Pharmacologie Toxicologie INRA, Toulouse, France
    Chem Biol Interact 159:169-79. 2006
    ..was measured in A549 cells (calcein or 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein, BCECF) and in HL60-MRP1 (calcein). Ivermectin induced calcein and BCECF retention in A549 cells (IC(50) at 1 and 2...
  100. ncbi Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1)
    Florinda Gennuso
    Neuropharmacology Section, OASI Institute for Research and Care on Mental Retardation and Brain Aging, 94018 Troina, Italy
    Proc Natl Acad Sci U S A 101:2470-5. 2004
    ..brain against cytotoxic insults, express the ATP-dependent transporter, multidrug resistance-associated protein 1 (Mrp1), which mediates export of organic anions, probably including UCB...

Research Grants75

  1. Effect of nutritional status on MRP2 expression and biliary excretion of bispheno
    Angela L Slitt; Fiscal Year: 2010
    ..Preliminary data demonstrates that RES increases the mRNA and protein expression of Mrp1-4, 6 in human hepatocytes and mouse liver along with induction of genes regulated by the transcription factor ..
  2. Effect of nutritional status on MRP2 expression and biliary excretion of bispheno
    ANGELA SLITT; Fiscal Year: 2009
    ..Preliminary data demonstrates that RES increases the mRNA and protein expression of Mrp1-4, 6 in human hepatocytes and mouse liver along with induction of genes regulated by the transcription factor ..
  3. Effect of nutritional status on MRP2 expression and biliary excretion of bispheno
    ANGELA SLITT; Fiscal Year: 2009
    ..Preliminary data demonstrates that RES increases the mRNA and protein expression of Mrp1-4, 6 in human hepatocytes and mouse liver along with induction of genes regulated by the transcription factor ..
  4. TRANSPORT CHARACTERISTICS OF PEPTIDE MIMETICS
    RONALD BORCHARDT; Fiscal Year: 2003
    ..g., multidrug resistance associated protein (MDR1) and multidrug resistance associated proteins (MRP1, MRP2))...
  5. Molecular Targeting of Drug Delivery System to Cancer
    Tamara Minko; Fiscal Year: 2010
    ..drug (doxorubicin);(3) suppressor of pump drug resistance (antisense oligonucleotides or siRNA targeted to MRP1 and MRP2 proteins);(4) suppressor of nonpump cellular resistance (antisense oligonucleotides or siRNA targeted to ..
  6. Molecular Targeting of Drug Delivery System to Cancer
    Tamara Minko; Fiscal Year: 2007
    ..drug (doxorubicin); (3) suppressor of pump drug resistance (antisense oligonucleotides or siRNA targeted to MRP1 and MRP2 proteins); (4) suppressor of nonpump cellular resistance (antisense oligonucleotides or siRNA targeted to ..
  7. Molecular Targeting of Drug Delivery System to Cancer
    Tamara Minko; Fiscal Year: 2009
    ..drug (doxorubicin); (3) suppressor of pump drug resistance (antisense oligonucleotides or siRNA targeted to MRP1 and MRP2 proteins); (4) suppressor of nonpump cellular resistance (antisense oligonucleotides or siRNA targeted to ..
  8. MECHANISM OF ATP DEPENDENT TRANSPORT BY MRP1 PROTEIN
    Xiu Bao Chang; Fiscal Year: 2005
    Overexpression of P-glycoprotein (P-gp) and/or multidrug resistance-associated protein (MRP1) is associated with resistance of tumors to a wide range of chemotherapeutic drugs...
  9. Improved Anti-HIV Therapy with P-glycoprotein Inhibitors
    KEVIN FRENCH; Fiscal Year: 2002
    ..The closely related transporter MRP1 is expressed by all normal tissues, so that inhibition of this protein increases drug toxicity in non-target ..
  10. Two Photon Imaging of Drug Uptake Efflux & Modulation in MDR Tumor Cells in vivo
    AHMAD SAFA; Fiscal Year: 2007
    ..P-glycoprotein (Pgp, product of the MDR1 gene) and the Multidrug resistance Related Protein (MRP, product of the MRP1 gene) are membrane transporters that produce increased drug effiux from tumor cells...
  11. Benzo[i]phenanthridines: TOP1-Targeting Antitumor Agents
    EDMOND LAVOIE; Fiscal Year: 2006
    ..overcoming multidrug resistance associated with efflux transporters such as BCRP, as well as MDR1 (P-glycoprotein), MRP1, and LRP; 2) to assess in vivo efficacy using various human tumor cell lines, including those that express MDR1 and ..
  12. ATP-Ubiquitin Dependent Proteolysis
    Arthur L Haas; Fiscal Year: 2010
    ..Specific Aim 3 will continue studies on the enzymology of Mdm2 and MdmX homo- and heterodimers as ubiquitin ligases...
  13. In vivo function of Mdm2 E3 ubiquitin ligase
    Yanping Zhang; Fiscal Year: 2010
    ..that compromise p53 functions occur in 50% of human cancers, and elevated levels of two p53 inhibitors Mdm2 and Mdm4 occur in most of the rest...
  14. Differential regulation of cardiomyocyte survival and hypertrophy
    Peter Erhardt; Fiscal Year: 2010
    The overall goal of this application is to investigate the role of Mdm2 and its homolog Mdm4 in maladaptive cardiac hypertrophy and the associated apoptosis...
  15. Structural and Functional Characterization of BRCA1/BARD1
    Rachel E Klevit; Fiscal Year: 2010
    ..effort to develop new molecular insights and tools for another RING E3 ligase that is critical in cancers, Mdm2/MdmX. The overall goals for the next grant period are 1) elucidate structural and functional determinants of mono-..
  16. Structural and Functional Characterization of BRCA1/BARD1
    Rachel Klevit; Fiscal Year: 2009
    ..effort to develop new molecular insights and tools for another RING E3 ligase that is critical in cancers, Mdm2/MdmX. The overall goals for the next grant period are 1) elucidate structural and functional determinants of mono-..
  17. ONTOGENY OF HEPATIC ION TRANSPORT
    Frederick Suchy; Fiscal Year: 2007
    ..Finally, the development of the canalicular multi specific organic anion transporter (cMOAT/Mrp1) will be defined including a correlation of transport activity in canalicular membrane vesicles with levels of Mrp2 ..
  18. Metabolism and Pharmacogenetics in MDMA-Induced Toxicity
    Rafael de la Torre; Fiscal Year: 2009
    ..that regulate the efflux from hepatocytes and the passage through the blood brain barrier of conjugates such as MRP1 may play a role in MDMA neurotoxicity...
  19. Function of the MRP Family
    GARY KRUH; Fiscal Year: 2006
    b>MRP1 and MRP2, the founding members of the MRP family of ABC transporters, are drug efflux pumps that play prominent roles in cellular resistance to anticancer agents and in drug distribution...
  20. Function of the MRP Family
    GARY KRUH; Fiscal Year: 2006
    b>MRP1 and MRP2, the founding members of the MRP family of ABC transporters, are drug efflux pumps that play prominent roles in cellular resistance to anticancer agents and in drug distribution...
  21. Studies on a Novel Taxane Pump
    Elizabeth Hopper Borge; Fiscal Year: 2007
    ..Since MRP7 has a distinct phenotype and has the lowest homology to MRP1 of all the MRP subfamily members, it is of interest to determine the biochemical parameters which are responsible ..
  22. ATP-Ubiquitin Dependent Proteolysis
    Arthur L Haas; Fiscal Year: 2010
    ..Specific Aim 3 will continue studies on the enzymology of Mdm2 and MdmX homo- and heterodimers as ubiquitin ligases...
  23. ATP-Ubiquitin Dependent Proteolysis
    Arthur L Haas; Fiscal Year: 2011
    ..Specific Aim 3 will continue studies on the enzymology of Mdm2 and MdmX homo- and heterodimers as ubiquitin ligases...
  24. Application of ABC transporters toward enhanced arsenic detoxification
    MELISSA PISCHKE; Fiscal Year: 2007
    ..2) Explore the effects of corresponding mutations on human and plant YCF1 homologs. Human (MRP1, 2) and plant (AtMRPI, 3) multidrug resistance genes will be introduced into Aycfl yeast, and tested for their ..
  25. Regulation of Ionizing Radiation Induced DNA Damage Response
    Xiaochun Yu; Fiscal Year: 2010
    ..In this proposal, we plan to not only dissect the molecular mechanism of RNF8 underlining ionizing radiation-induced DNA damage response, but also examine the role of RNF8 in tumorigenesis in vivo. ..
  26. CLONING GENES THAT REGULATE MYOCARDIOCYTE PROLIFERATION
    Loren Field; Fiscal Year: 2002
    ..If the putative regulatory roles for these proteins are confirmed, they may serve as intracellular targets for therapeutic myocardial growth in the adult heart. ..
  27. ATP-UBIQUITIN-DEPENDENT PROTEOLYSIS
    Arthur Haas; Fiscal Year: 2003
    ..Specific Aim 3 will use kinetic methods to examine the mechanism of Mdm2- and MdmX-catalyzed autoubiquitination and p53 conjugation, the linkage specificity of the non-canonical polyubiquitin ..