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Genomes and Genes
| KIF5ASummaryGene Symbol: KIF5A Description: kinesin family member 5A Alias: D12S1889, MY050, NKHC, SPG10, KIF5A variant protein, kinesin heavy chain isoform 5A, kinesin heavy chain neuron-specific 1, kinesin, heavy chain, neuron-specific, neuronal kinesin heavy chain Species: human Top Publications
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Publications
Common variants at CD40 and other loci confer risk of rheumatoid arthritisSoumya Raychaudhuri
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Nat Genet 40:1216-23. 2008..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall).- Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locusE Y M G Fung
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
Genes Immun 10:188-91. 2009..with T1D in the regions containing genes: 2q32/STAT4, 17q21/STAT3, 5p15/ERAP1 (ARTS1), 6q23/TNFAIP3 and 12q13/KIF5A/PIP4K2C with allelic P-values ranging from 3.70 x 10(-3) to 3.20 x 10(-5)... - Cloning and localization of a conventional kinesin motor expressed exclusively in neuronsJ Niclas
Department of Pharmacology, University of California, San Francisco 94143
Neuron 12:1059-72. 1994..thought to serve all cell types, we document here that neurons express a second conventional kinesin heavy chain (nKHC) that is 65% identical in amino acid sequence to the ubiquitously expressed kinesin heavy chain (uKHC)... - Two kinesin light chain genes in mice. Identification and characterization of the encoded proteinsA Rahman
Howard Hughes Medical Institute, Division of Cellular and Molecular Medicine, Program in Biomedical Sciences and Department of Pharmacology, University of California San Diego, La Jolla, California 92093 0683, USA
J Biol Chem 273:15395-403. 1998..These results indicate that the mammalian nervous system contains multiple kinesin light chain gene products with potentially distinct functions... - The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis RegisterDarren Plant
ARC Epidemiology Unit, Manchester Academic Health Sciences Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Rheumatology (Oxford) 50:78-84. 2011..We therefore sought to investigate the role of recently identified RA susceptibility SNP markers in predicting erosive outcome in patients with recent-onset inflammatory polyarthritis (IP)... - A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosisStefan Wieczorek
Department of Human Genetics, Ruhr University, MA5 39, 44780, Bochum, Germany
J Mol Med (Berl) 88:413-21. 2010..22 single nucleotide polymorphisms (SNPs) within or in the vicinity of CCL21, CD40, CDK6, IL21, IL2RB, IRF5, KIF5A, KLF12, MMEL1, PRKCQ, STAT4, TNFAIP3, and TRAF1/C5 have been genotyped in >600 German WG cases and >800 matched .. - Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1J D Cooper
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
Genes Immun 10:S95-120. 2009..org). Support was obtained for a newly identified T1D candidate locus on chromosome 12q13.3-12q14.1 (rs1678536/KIF5A: P=8.1 x 10(-3); relative risk (RR) for minor allele=0.89, 95% CI=0.82-0... - Tight functional coupling of kinesin-1A and dynein motors in the bidirectional transport of neurofilamentsAtsuko Uchida
Center for Molecular Neurobiology and Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
Mol Biol Cell 20:4997-5006. 2009We have tested the hypothesis that kinesin-1A (formerly KIF5A) is an anterograde motor for axonal neurofilaments... - Overexpression of kinesins mediates docetaxel resistance in breast cancer cellsSarmishtha De
Department of Genetics and Pathology, Case Western Reserve University, Case Comprehensive Cancer Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Cancer Res 69:8035-42. 2009..When KIFC3 or the additional kinesins KIFC1, KIF1A, or KIF5A were overexpressed in the breast cancer cell lines MDA-MB231 and MDA-MB 468, the cells became more resistant to .. - Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritisAnne Hinks
Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK
Ann Rheum Dis 69:1049-53. 2010..Rheumatoid arthritis (RA) is an autoimmune disease that shares similar clinical and pathological features with JIA and, therefore, recently identified confirmed RA susceptibility loci are also excellent JIA candidate loci... - Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritisMichael P M van der Linden
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 60:2242-7. 2009..genome-wide association studies identified 6 genetic regions for susceptibility to autoantibody-positive RA: CD40, KIF5A/PIP4K2C, CDK6, CCL21, PRKCQ, and MMEL1/TNFRSF14... - Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasisYonghong Li
Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
Semin Immunol 21:318-27. 2009..convincing statistical evidence for at least ten non-HLA related risk genes or loci (C5/TRAF1, CD40, CTLA4, KIF5A/PIP4K2C, MMEL1/TNFRSF14, PADI4, PRKCQ, PTPN22, STAT4, and TNFAIP3/OLIG3) for RA and six (IL12B, IL13, IL23R, STAT2/.. - Complicated forms of autosomal dominant hereditary spastic paraplegia are frequent in SPG10Cyril Goizet
INSERM, UMR_S679, Paris, France
Hum Mutat 30:E376-85. 2009..Only a few different mutations in the SPG10 gene, KIF5A, have been described in pure dominant forms of the disease... - Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophreniaMasashi Ikeda
Department of Psychiatry, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
Hum Mol Genet 17:3212-22. 2008..LIS1), 14-3-3epsilon (YWHAE), growth factor receptor bound protein 2 (GRB2) and Kinesin family 5A of Kinesen1 (KIF5A)], assessing a total of 25 tagging single-nucleotide polymorphisms (SNPs) in a Japanese population... - Genetics in neuroendocrine immunology: implications for rheumatoid arthritis and osteoarthritisKlaus Stark
Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
Ann N Y Acad Sci 1193:10-4. 2010..genes like HLA-DRB1, PTPN22, STAT4, TRAF1/C5, OLIG3/TNFAIP3, CD40, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, IL2RB, and KIF5A-PIP4K2C. These association signals explain more than 50% of the genetic influence on RA... - Kinesin passing permanent blockages along its protofilament trackKerstin Dreblow
Leibniz Institute for Age Research Fritz Lipmann Institute FLI, Beutenbergstrasse 11, 07745 Jena, Germany
Biochem Biophys Res Commun 395:490-5. 2010..that exactly the kinesin-binding sites were occupied and to avoid steric effects exerted by large molecules, the KIF5A motor domain was used for blocking... - Japan spastic paraplegia research consortium (JASPAC)Yoshihisa Takiyama
Department of Neurology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
Rinsho Shinkeigaku 50:931-4. 2010..families, SPG4 was the most common form, accounting for 47%, followed by SPG31 (4%), SPG3A (3%), SPG8 (1%), and SPG10 (1%)... - Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native populationH S El-Gabalawy
Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Genes Immun 12:568-74. 2011..associated with RA, including PTPN22, TRAF1-C5, CTLA4, PADI4, STAT4, FCRL3, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, KIF5A-PIP4K2C, IL2RB, TNFAIP3, IL10-1082G/A and REL... - Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancerMin Han Tan
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue NE 50, Cleveland, OH 44195, USA
Breast Cancer Res Treat 131:849-58. 2012..49) and cisplatin (P = 0.10). Overexpression of KIFC3 and KIF5A in pre-chemotherapy samples similarly predicted resistance to paclitaxel in the MDACC cohorts (P = 0... - Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkersBrian C Tooker
Division of Allergy and Clinical Immunology, University of Colorado Denver, Aurora, CO 80045, USA
Biomarkers 16:181-91. 2011..To identify biomarkers for cancer in asbestosis patients... - A novel mutation in KIF5A gene causing hereditary spastic paraplegia with axonal neuropathyOlimpia Musumeci
Department of Neurosciences, Psychiatry and Anaesthesiology, University of Messina, Messina, Italy
Neurol Sci 32:665-8. 2011..Among the autosomal dominant HSPs (AD-HSPs), SPG10 is a rare form due to mutations in KIF5A gene (locus 12q13.3)... - A hereditary spastic paraplegia mutation in kinesin-1A/KIF5A disrupts neurofilament transportLina Wang
Center for Molecular Neurobiology and Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
Mol Neurodegener 5:52. 2010..One of the dominantly inherited forms of this disease (spastic gait type 10, or SPG10) is caused by point mutations in kinesin-1A (also known as KIF5A), which is thought to be an anterograde motor for .. - Genetic variants of connexin37 are associated with carotid intima-medial thickness and future onset of ischemic strokeHsin Bang Leu
Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
Atherosclerosis 214:101-6. 2011..This study aimed to investigate the impacts of genetic variants on IMT and future development of ischemic stroke in a cohort, followed by an independent replication study... - Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transportPing Shi
Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
Biochim Biophys Acta 1802:707-16. 2010..to the dynein situation, mutant SOD1 did not interact with anterograde transport motors of the kinesin-1 family (KIF5A, B and C)... - The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosisA Alcina
Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas CSIC, Granada, Spain
Genes Immun 11:439-45. 2010..Three SNPs were found to be associated with MS: rs1678542 in KIF5A (P=0.001, odds ratio (OR)=1.13, 95% confidence interval (CI)=1.05-1.23); rs3184504 in SH2B3 (P=0.00001, OR=1... - Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markersDarren Plant
ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
Ann Rheum Dis 69:1548-53. 2010..Genome-wide association studies have identified non-human leucocyte antigen RA susceptibility loci which associate with RA with low-to-moderate risk... - Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatmentRachael J L Tan
Arthritis Research Campaign Epidemiology Unit, Stopford Building, Oxford Road, University of Manchester, Manchester M13 9PT, UK
Ann Rheum Dis 69:1029-35. 2010..The aim of the current study was to investigate the association of markers within confirmed RA susceptibility loci with the response to anti-TNF treatment... - Genetic variants in the prediction of rheumatoid arthritisAnnette H M van der Helm-van Mil
Leiden University Medical Center, Department of Rheumatology, Leiden, The Netherlands
Ann Rheum Dis 69:1694-6. 2010.... - The role of Kinesin neck linker and neck in velocity regulationNikolina Kalchishkova
Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, D 07745 Jena, Germany
J Mol Biol 382:127-35. 2008..To elucidate the structural motifs contributing to velocity regulation, we expressed a set of Eg5- and KIF5A-based chimeric proteins with interchanged native neck linker and neck elements... - Beta-dystrobrevin interacts directly with kinesin heavy chain in brainP Macioce
Laboratory of Cell Biology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
J Cell Sci 116:4847-56. 2003..Four overlapping clones were identified that encoded Kif5A, a neuronal member of the Kif5 family of proteins that consists of the heavy chains of conventional kinesin... - Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5AChun hong Xia
Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093 0683, USA
J Cell Biol 161:55-66. 2003..we used homologous recombination to generate mice lacking the neuronal-specific conventional kinesin heavy chain, KIF5A. Because null KIF5A mutants die immediately after birth, a synapsin-promoted Cre-recombinase transgene was used to .. - A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)Evan Reid
Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, United Kingdom
Am J Hum Genet 71:1189-94. 2002We have identified a missense mutation in the motor domain of the neuronal kinesin heavy chain gene KIF5A, in a family with hereditary spastic paraplegia... - Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localizationTimur A Mavlyutov
Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Traffic 3:630-40. 2002..The C-terminal domains of KIF5B and KIF5C, but not KIF5A, associate directly with importin-beta in a RanGTPase-dependent fashion in vivo and in vitro, indicating importin-.. - Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendritesMitsutoshi Setou
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
Nature 417:83-7. 2002..These results indicate that directly binding proteins can determine the traffic direction of a motor protein... - Kinesin light-chain KLC3 expression in testis is restricted to spermatidsA Junco
Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada T2N 4N1
Biol Reprod 64:1320-30. 2001..Interestingly, the expression profiles of the three known KHCs and KLC3 differ significantly: Kif5a and Kif5b are not expressed after meiosis, and Kif5c is expressed at an extremely low level in spermatids but is .. - Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domainsX Espanel
Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Biol Chem 276:14514-23. 2001..Since overexpression of an activated form of c-Yes resulted in tyrosine phosphorylation of p53BP-2, we propose that the p53BP-2 phosphorylation, possibly in the WW1 domain-binding motif, might negatively regulate the YAP.p53BP-2 complex... - KIF5C, a novel neuronal kinesin enriched in motor neuronsY Kanai
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Neurosci 20:6374-84. 2000..KIF5s, the heavy chains of conventional kinesin (KHC), are originally identified members of KIFs, and neuronal KIF5A and ubiquitous KIF5B have been identified so far... - Defective kinesin heavy chain behavior in mouse kinesin light chain mutantsA Rahman
Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California 92093 0683, USA
J Cell Biol 146:1277-88. 1999Conventional kinesin, kinesin-I, is a heterotetramer of two kinesin heavy chain (KHC) subunits (KIF5A, KIF5B, or KIF5C) and two kinesin light chain (KLC) subunits. While KHC contains the motor activity, the role of KLC remains unknown... - A new locus for autosomal dominant "pure" hereditary spastic paraplegia mapping to chromosome 12q13, and evidence for further genetic heterogeneityE Reid
Department of Medical Genetics, University of Cambridge, Cambridge CB2 2XY, United Kingdom
Am J Hum Genet 65:757-63. 1999..61 at D12S1691, allowing us to assign a new locus for ADPHSP (a locus that we have designated "SPG10") to this region. Haplotype construction and analysis of recombination events narrowed the SPG10 locus to a 9... - Assignment of GALGT encoding beta-1, 4N-acetylgalactosaminyl-transferase (GalNAc-T) and KIF5A encoding neuronal kinesin (D12S1889) to human chromosome band 12q13 by assignment to ICI YAC 26EG10 and in situ hybridization. P J Hamlin
Molecular Medicine Unit, University of Leeds, St. James's University Hospital, Leeds (UK
Cytogenet Cell Genet 82:267-8. 1998 - Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus buddingIdo Amit
Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
Genes Dev 18:1737-52. 2004.... - Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegiaM Fichera
Genetic Diagnostic Laboratory, IRCCS Oasi M SS Troina, Italy
Neurology 63:1108-10. 2004..report a four-generation pedigree segregating an autosomal dominant phenotype for HSP and showing a linkage to the SPG10 locus, coding for Kinesin family member 5A... - GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesinKieran Brickley
Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
J Biol Chem 280:14723-32. 2005..Further studies revealed that GRIF-1 was predominantly associated with KIF5A in the brain and with KIF5B in both the heart and in HEK 293 cells... - A novel candidate locus on chromosome 11p14.1-p11.2 for autosomal dominant hereditary spastic paraplegiaGuo Hua Zhao
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
Chin Med J (Engl) 121:430-4. 2008..Thirteen loci for autosomal dominant HSP have been mapped... - Conventional kinesin holoenzymes are composed of heavy and light chain homodimersScott R DeBoer
Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Biochemistry 47:4535-43. 2008..The products of three kinesin-1 (kinesin-1A, -1B, and -1C, formerly KIF5A, -B, and -C) and two KLC (KLC1, KLC2) genes are expressed in mammalian nervous tissue, but the functional .. - Kinesin-driven transport in cell-free environmentKonrad J Böhm
Leibniz Institute for Age Research, Fritz Lipmann Institute, Molecular Motors Lab, Beutenbergstrasse 11, D 07745 Jena, Germany
Cell Biol Int 32:588-90. 2008..Moreover, it demonstrates that the neuron-specific kinesin KIF5A enables the formation of microtubules under conditions where pure tubulin does not assemble. - SPG10 is a rare cause of spastic paraplegia in European familiesR Schule
Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
J Neurol Neurosurg Psychiatry 79:584-7. 2008b>SPG10 is an autosomal dominant form of hereditary spastic paraplegia (HSP), which is caused by mutations in the neural kinesin heavy chain KIF5A gene, the neuronal motor of fast anterograde axonal transport... - Effect of spastic paraplegia mutations in KIF5A kinesin on transport activityBettina Ebbing
Institute for Cell Biology, University of Munich, Schillerstr 42, D 80336 Munich, Germany
Hum Mol Genet 17:1245-52. 2008..It is linked to at least 30 loci, among them SPG10, which causes dominant forms and originates in point mutations in the neuronal Kinesin-1 gene (KIF5A)... - Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and functionKyoung In Cho
Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
Traffic 8:1722-35. 2007..with the ubiquitous and CNS-specific kinesins, KIF5B and KIF5C, respectively, but not with the highly homologous KIF5A. Here, we determine the molecular and biological bases of the selective interaction between RanBP2 and KIF5B/KIF5C... - The role of hereditary spastic paraplegia related genes in multiple sclerosis. A study of disease susceptibility and clinical outcomeG C DeLuca
University Dept of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Woodstock Rd, Oxford, OX2 6LE, UK
J Neurol 254:1221-6. 2007..could not provide any evidence to suggest that genes involved in the pathogenesis of HSP (Paraplegin, NIPA1, KIF5A, HSPD1, Atlastin, Spartin, Spastin, PLP1, L1CAM, Maspardin and BSCL2) play a role in susceptibility to, or .. - DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2Tomoyasu Shinoda
Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Showa, Nagoya 466 8550, Japan
J Neurosci 27:4-14. 2007..DISC1 formed a ternary complex with Grb2 and kinesin heavy chain KIF5A of Kinesin-1... - Eight novel mutations in SPG4 in a large sample of patients with hereditary spastic paraplegiaFrancesca Crippa
Laboratory of Molecular Biology, IRCCS Eugenio Medea, Via D L Monza 20, 23842 Bosisio Parini, Lecco, Italy
Arch Neurol 63:750-5. 2006..Mutations in the SPG4 gene, which encodes spastin protein, are responsible for up to 45% of autosomal dominant cases... - Mutation in KIF5A can also cause adult-onset hereditary spastic paraplegiaMarcia A Blair
Department of Neurology, Vanderbilt University, Nashville, TN 37232 8552, USA
Neurogenetics 7:47-50. 2006Autosomal dominant hereditary spastic paraplegia (AD HSP) linked to chromosome 12q (SPG10) is caused by mutations in the neuronal kinesin heavy-chain KIF5A gene... - Molecular basis of dystrobrevin interaction with kinesin heavy chain: structural determinants of their bindingMarina Ceccarini
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
J Mol Biol 354:872-82. 2005..protein and localized the dystrobrevin-binding site on the cargo-binding domain of neuronal kinesin heavy chain (Kif5A)... - Chromosomal localization reveals three kinesin heavy chain genes in mouseCh Xia
Division of Cellular and Molecular Medicine, Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0683, USA
Genomics 52:209-13. 1998..Here we definitively demonstrate that mouse has three kinesin heavy chain genes, Kif5a, Kif5b, and Kif5c...
Research Grants
- Axonal Transport Deficits during Hereditary Spastic ParaplegiaGERARDO ANDRES MORFINI; Fiscal Year: 2010..Moreover, loss of function mutations in the SPG10 locus coding for a specific subunit of the molecular motor protein conventional kinesin lead to HSP, suggesting ..
- GENETIC AND IMMUNOLOGIC ANALYSIS OF MICROTUBULE PROTEINSLawrence Goldstein; Fiscal Year: 2006..Null and conditional knockout mutants in the three kinesin heavy chain (KIF5A, KIF5B, and KIF5C), and the two major kinesin light chain (KLC1 and KLC2) genes in the mouse will be generated and ..
- GENETIC AND IMMUNOLOGIC ANALYSIS OF MICROTUBULE PROTEINSLawrence Goldstein; Fiscal Year: 2002..conventional kinesin (kinesin-I) by analyzing mutants in the three different kinesin heavy chain subunits in mice (KIF5A, KIF5B, and KIF5C)...
- Mechanism of spastin-mediated microtubule severingSusan White; Fiscal Year: 2007..appears to play an important role in maintaining neural health, as mutations in microtubule motors, such as KIF5a and dynein, also cause neurodegenerative disorders...
- AXONAL TRANSPORT OF NEUROFILAMENTSAnthony Brown; Fiscal Year: 2007..The long-term goal of our research is to determine the mechanism and regulation of neurofilament protein transport along axons and the mechanisms that lead to the accumulation of neurofilaments in neurofilamentous neuropathies. ..
- Assembly and Axonal Transport of NeurofilamentsAnthony Brown; Fiscal Year: 2010....
- ASSEMBLY AND AXONAL TRANSPORT OF NEUROFILAMENT PROTEINSAnthony Brown; Fiscal Year: 2002..By testing specific hypotheses on the assembly and axonal transport of neurofilaments, the studies proposed here represent an important step toward this goal. ..