HK1

Summary

Gene Symbol: HK1
Description: hexokinase 1
Alias: HK1-ta, HK1-tb, HK1-tc, HKI, HXK1, HK I, brain form hexokinase, glycolytic enzyme, hexokinase type I, hexokinase-1
Species: human

Top Publications

  1. ncbi Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits
    Amelie Bonnefond
    CNRS UMR 8090, Institute of Biology and Lille 2 University, Pasteur Institute, Lille, France
    Diabetes 58:2687-97. 2009
  2. ncbi Gene expression and biological significance of hexokinase in erythroid cells
    Koko Murakami
    Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Acta Haematol 108:204-9. 2002
  3. ncbi Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS Genet 4:e1000312. 2008
  4. ncbi Glucose 6-phosphate release of wild-type and mutant human brain hexokinases from mitochondria
    D Andrew Skaff
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
    J Biol Chem 280:38403-9. 2005
  5. ncbi Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity
    Laetitia Arzoine
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel 84105
    J Biol Chem 284:3946-55. 2009
  6. ncbi Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding
    Salah Abu-Hamad
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Biol Chem 283:13482-90. 2008
  7. ncbi HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia
    Richard van Wijk
    Department of Clinical Chemistry and the Department of Hematology, University Medical Center Utrecht, The Netherlands
    Blood 101:345-7. 2003
  8. ncbi Hexokinase mutations that produce nonspherocytic hemolytic anemia
    M Bianchi
    Institute of Biological Chemistry G Fornaini, University of Urbino, Italy
    Blood Cells Mol Dis 21:2-8. 1995
  9. ncbi Generalized hexokinase deficiency in the blood cells of a patient with nonspherocytic hemolytic anemia
    G Rijksen
    Blood 61:12-8. 1983
  10. ncbi Identification of the cDNA for human red blood cell-specific hexokinase isozyme
    K Murakami
    Division of Pediatric Hematology, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Blood 89:762-6. 1997

Research Grants

  1. REGULATORY ENZYMES OF GLYCOLYSIS AND GLUCONEOGENESIS
    HERBERT FROMM; Fiscal Year: 1993
  2. Glycolysis and Glutamate Storage into Synaptic Vesicles
    Tetsufumi Ueda; Fiscal Year: 2007
  3. Glycolysis and Glutamate Storage into Synaptic Vesicles
    Tetsufumi Ueda; Fiscal Year: 2010
  4. HORMONAL CONTROL OF HEPATIC GLUCONEOGENESIS/GLYCOLYSIS
    Alex Lange; Fiscal Year: 2005
  5. CORNEAL STROMAL-EPITHELIAL INTERACTIONS DURING REPAIR
    JAMES ZIESKE; Fiscal Year: 1993
  6. HEXOKINASE II--STRUCTURE, REGULATION AND FUNCTION
    DARYL GRANNER; Fiscal Year: 2002
  7. HEXOKINASE II--STRUCTURE, REGULATION AND FUNCTION
    DARYL GRANNER; Fiscal Year: 1993
  8. Genetic Dissection of Age-dependent Neuroprotection Mechanisms in Drosophila
    BARRY S GANETZKY; Fiscal Year: 2010
  9. High Throughput Screening to Identify Inhibitors of a Fifth Mammalian Hexokinase
    Jeffrey Johnson; Fiscal Year: 2007
  10. Identification of Inhibitors of Trypanosoma Brucei Hexokinases
    James Morris; Fiscal Year: 2007

Detail Information

Publications144 found, 100 shown here

  1. ncbi Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits
    Amelie Bonnefond
    CNRS UMR 8090, Institute of Biology and Lille 2 University, Pasteur Institute, Lille, France
    Diabetes 58:2687-97. 2009
    ..a genome-wide association study reported an association between A1C and rs7072268 within HK1 (encoding hexokinase 1), which catalyzes the first step of glycolysis...
  2. ncbi Gene expression and biological significance of hexokinase in erythroid cells
    Koko Murakami
    Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Acta Haematol 108:204-9. 2002
    ..It is most likely that RBCs are most labile as a result of HK-I/R deficiency since the HK-I gene but not the other isozyme genes are expressed in fetal and adult RBCs...
  3. ncbi Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS Genet 4:e1000312. 2008
    ..8 x 10(-12)), SLC30A8 (rs13266634; P = 9.8 x 10(-8)), G6PC2 (rs1402837; P = 6.8 x 10(-10)), and HK1 (rs7072268; P = 6.4 x 10(-9)) loci...
  4. ncbi Glucose 6-phosphate release of wild-type and mutant human brain hexokinases from mitochondria
    D Andrew Skaff
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
    J Biol Chem 280:38403-9. 2005
    One molecule of glucose 6-phosphate inhibits brain hexokinase (HKI) with high affinity by binding to either one of two sites located in distinct halves of the enzyme...
  5. ncbi Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity
    Laetitia Arzoine
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel 84105
    J Biol Chem 284:3946-55. 2009
    ..Moreover, VDAC1-based peptides interfering with HK-mediated anti-apoptotic activity may potentiate the efficacy of conventional chemotherapeutic agents...
  6. ncbi Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding
    Salah Abu-Hamad
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Biol Chem 283:13482-90. 2008
    ..Finally, these findings suggest that interference with the binding of HK-I to mitochondria by VDAC1-derived peptides may offer a novel strategy by which to potentiate the efficacy of conventional chemotherapeutic agents...
  7. ncbi HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia
    Richard van Wijk
    Department of Clinical Chemistry and the Department of Hematology, University Medical Center Utrecht, The Netherlands
    Blood 101:345-7. 2003
    ..We report a novel homozygous missense mutation in exon 15 (c.2039C>G, HK [hexokinase] Utrecht) of HK1, the gene that encodes red blood cell-specific hexokinase-R, in a patient previously diagnosed with hexokinase ..
  8. ncbi Hexokinase mutations that produce nonspherocytic hemolytic anemia
    M Bianchi
    Institute of Biological Chemistry G Fornaini, University of Urbino, Italy
    Blood Cells Mol Dis 21:2-8. 1995
    Among glycolytic enzyme defects, hexokinase (ATP: D-hexose 6-phosphotransferase, EC 2.7.1.1; HK) deficiency is a very rare disease where the predominant clinical effect is nonspherocytic hemolytic anemia...
  9. ncbi Generalized hexokinase deficiency in the blood cells of a patient with nonspherocytic hemolytic anemia
    G Rijksen
    Blood 61:12-8. 1983
    ..Although the total hexokinase activity in lymphocytes was normal, the amount of hexokinase type I was decreased to about 50% of normal...
  10. ncbi Identification of the cDNA for human red blood cell-specific hexokinase isozyme
    K Murakami
    Division of Pediatric Hematology, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Blood 89:762-6. 1997
    ..Its nucleotide sequence was identical to HKI cDNA except for the 5' extreme end...
  11. ncbi Hexokinase regulates kinetics of glucose transport and expression of genes encoding hexose transporters in Saccharomyces cerevisiae
    T Petit
    , 28029 Madrid, Spain
    J Bacteriol 182:6815-8. 2000
    ..Expression of genes encoding hexokinases from Schizosaccharomyces pombe or Yarrowia lipolytica in a hxk1 hxk2 glk1 strain prevented derepression of the high-affinity transport system at high concentrations of glucose.
  12. ncbi Immunohistochemistry of neuron-specific and glia-specific proteins
    T Iwanaga
    Department of Anatomy, Niigata University School of Medicine, Japan
    Arch Histol Cytol 52:13-24. 1989
    ..Neuron-specific enolase (NSE), a brain-specific isozyme of the glycolytic enzyme enolase, is characterized by its consistent occurrence in the cytoplasm of mature neurons...
  13. ncbi Family origin and the response of threespine stickleback, Gasterosteus aculeatus, to thermal acclimation
    H Guderley
    , , Quebec, Canada
    J Comp Physiol B 171:91-101. 2001
    ..growth, and food conversion, relative tissue and organ masses and activities of a mitochondrial and a glycolytic enzyme in pectoral and axial muscle of individually housed fish from six families during acclimation to 8 degrees C ..
  14. ncbi The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha
    H K Jindal
    Department of Biochemistry, University of Nebraska Medical Center, Omaha 68198
    J Biol Chem 266:5169-76. 1991
    ..By amino acid sequence homology, we have identified PRP 2 as the glycolytic enzyme 3-phosphoglycerate kinase...
  15. ncbi Identification, sequence analysis, and expression of a Corynebacterium glutamicum gene cluster encoding the three glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and triosephosphate isomerase
    B J Eikmanns
    Institut für Biotechnologie 1 des Forschungszentrums Jülich GmbH, Germany
    J Bacteriol 174:6076-86. 1992
    To investigate a possible chromosomal clustering of glycolytic enzyme genes in Corynebacterium glutamicum, a 6.4-kb DNA fragment located 5' adjacent to the structural phosphoenolpyruvate carboxylase (PEPCx) gene ppc was isolated...
  16. ncbi Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs
    N Vionnet
    Centre National Recherche Scientifique, Institut Pasteur de Lille, France
    Diabetes 46:1062-8. 1997
    ..ISL1), caudal-type homeodomain 3 (CDX3), proprotein convertase 2 (PCSK2), cholecystokinin B receptor (CCKBR), hexokinase 1 (HK1), hexokinase 2 (HK2), mitochondrial FAD-glycerophosphate dehydrogenase (GPD2), liver and muscle forms of ..
  17. ncbi The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase works as an arsenate reductase in human red blood cells and rat liver cytosol
    Zoltan Gregus
    Department of Pharmacology and Pharmacotherapy, Toxicology Section, University of Pecs, Medical School, Pecs, Hungary
    Toxicol Sci 85:859-69. 2005
    ..In conclusion, the key glycolytic enzyme GAPDH can fortuitously catalyze the reduction of AsV to AsIII, if GSH, NAD, and glycolytic substrate are ..
  18. ncbi Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins
    Sandro E Fogaça
    Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Tres de Maio 100, São Paulo 04044 20, Brazil
    Biochem J 380:775-81. 2004
    The kininogenase activities of mouse (mK1), rat (rK1) and human (hK1) tissue kallikreins were assayed with the bradykinin-containing synthetic peptides Abz-MTEMARRPPGFSPFRSVTVQNH2 (where Abz stands for o-aminobenzoyl) and Abz-..
  19. ncbi Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver
    Daniel Cifuentes
    Institute for Research in Biomedicine, Universitat de Barcelona, Barcelona, Catalonia 08028, Spain
    J Biol Chem 283:5642-9. 2008
    ..b>Hexokinase type I or II (HKI, HKII) substitutes for GK in hepatomas and in embryonic livers...
  20. ncbi Computational study of glyceraldehyde-3-phosphate dehydrogenase of Entamoeba histolytica: implications for structure-based drug design
    Sangeeta Kundu
    Bioinformatics Centre, Bose Institute, Acharya J C Boses Centenary Building, P 1 12 C I T Scheme VIIM, Kolkata 700054, India
    J Biomol Struct Dyn 25:25-33. 2007
    ..dehydrogenase (GAPDH) of the pathogenic protozoa Entamoeba histolytica (Eh) is a major glycolytic enzyme and an attractive drug target since this parasite lacks a functional citric acid cycle and is dependent ..
  21. ncbi Vitamin A status of the minority ethnic group of Karen hill tribe children aged 1-6 years in Northern Thailand
    Prasong Tienboon
    Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200
    Asia Pac J Clin Nutr 16:158-62. 2007
    ..vitamin A status was assessed by using Simplified Dietary Assessment (SDA) method and Helen Keller International (HKI) food frequency method. Descriptive statistics were used to analyse the data...
  22. ncbi Entamoeba histolytica: computer-assisted modeling of phosphofructokinase for the prediction of broad-spectrum antiparasitic agents
    C L Byington
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    Exp Parasitol 87:194-202. 1997
    Pyrophosphate-dependent phosphofructokinase (PPi-PFK) is the rate-limiting glycolytic enzyme found in the pathogenic protists Entamoeba histolytica, Giardia lamblia, Toxoplasma gondii, Trichomonas vaginalis, and Naegleria fowleri...
  23. ncbi Novel alleles of yeast hexokinase PII with distinct effects on catalytic activity and catabolite repression of SUC2
    S Hohmann
    Laboratorium voor Moleculaire Celbiologie, Katholieke Universiteit Leuven, Heverlee, Flanders, Belgium
    Microbiology 145:703-14. 1999
    ..The phosphorylation of glucose or fructose is catalysed by hexokinase PI (Hxk1), hexokinase PII (Hxk2) and a specific glucokinase (Glk1)...
  24. ncbi Contribution of the mannan backbone of cryptococcal glucuronoxylomannan and a glycolytic enzyme of Staphylococcus aureus to contact-mediated killing of Cryptococcus neoformans
    Reiko Ikeda
    Department of Microbiology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    J Bacteriol 189:4815-26. 2007
    ..neoformans. Thus, TPI on S. aureus adheres to the capsule of C. neoformans by recognizing the structure of mannotriose units in the backbone of GXM; we suggest that this contact is required for killing of C. neoformans...
  25. ncbi Lysine biosynthesis in selected pathogenic fungi: characterization of lysine auxotrophs and the cloned LYS1 gene of Candida albicans
    R C Garrad
    Department of Microbiology, Miami University, Oxford, Ohio 45056
    J Bacteriol 174:7379-84. 1992
    ..and saccharopine dehydrogenase) of the alpha-aminoadipate pathway and glucose-6-phosphate dehydrogenase, a glycolytic enzyme used as a control, were demonstrated in wild-type cells of these organisms...
  26. ncbi The Botrytis cinerea hexokinase, Hxk1, but not the glucokinase, Glk1, is required for normal growth and sugar metabolism, and for pathogenicity on fruits
    Oliver Rui
    Phytopathology, Department of Biology, University of Kaiserslautern, 67653 Kaiserslautern, Germany
    Microbiology 153:2791-802. 2007
    ..In this study, the genes encoding glucokinase (Glk1) and hexokinase (Hxk1) from the plant-pathogenic ascomycete Botrytis cinerea were isolated and functionally characterized...
  27. ncbi Cloning, sequencing and functional overexpression of the Streptococcus equisimilis H46A gapC gene encoding a glyceraldehyde-3-phosphate dehydrogenase that also functions as a plasmin(ogen)-binding protein. Purification and biochemical characterization of
    K Gase
    Institute for Molecular Biology, Jena University, Germany
    Eur J Biochem 239:42-51. 1996
    ..2.1.12), a glycolytic enzyme apparently transported to the cell surface where it functions as a plasmin(ogen).binding protein...
  28. ncbi Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa
    D Westhoff
    Institut fur Zoophysiologie, Westfalische Wilhelms Universitat Munster, Germany
    J Cell Sci 110:1821-9. 1997
    Evidence is provided that the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase is covalently linked to the fibrous sheath...
  29. ncbi The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3-phosphate dehydrogenase
    B Modun
    Institute of Infections and Immunity, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    Infect Immun 67:1086-92. 1999
    ..the first 20 amino acid residues of Tpn with the protein databases revealed a high degree of homology to the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH)...
  30. ncbi Association of aciculin with dystrophin and utrophin
    A M Belkin
    Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599 7090
    J Biol Chem 270:6328-37. 1995
    Aciculin is a recently identified 60-kDa cytoskeletal protein, highly homologous to the glycolytic enzyme phosphoglucomutase type 1, (Belkin, A. M., Klimanskaya, I. V., Lukashev, M. E., Lilley, K., Critchley, D., and Koteliansky, V. E...
  31. ncbi Crystal structure of glucose-6-phosphate isomerase from Thermus thermophilus HB8 showing a snapshot of active dimeric state
    Hitoshi Yamamoto
    RIKEN SPring 8 Center, Harima Institute, 1 1 1 Kouto, Sayo cho, Sayo gun, Hyogo 679 5148, Japan
    J Mol Biol 382:747-62. 2008
    Glucose-6-phosphate isomerase (GPI) is a glycolytic enzyme with ill-defined oligomeric state...
  32. ncbi Ischemic preconditioning affects hexokinase activity and HKII in different subcellular compartments throughout cardiac ischemia-reperfusion
    Ebru Gurel
    Department of Anaesthesiology, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Appl Physiol 106:1909-16. 2009
    The glycolytic enzyme hexokinase (HK) is suggested to play a role in ischemic preconditioning (IPC)...
  33. ncbi Downeast anemia (dea), a new mouse model of severe nonspherocytic hemolytic anemia caused by hexokinase (HK(1)) deficiency
    L L Peters
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Blood Cells Mol Dis 27:850-60. 2001
    ..In linkage analysis, dea is nonrecombinant with the hexokinase-1 gene (Hk1) on mouse Chromosome 10...
  34. ncbi Changes in muscle mRNAs for hexokinase, phosphofructokinase-1 and glycogen synthase in acute and persistent hypoglycemia induced by tolbutamide in chickens
    Yoshinori Seki
    Animal Nutrition, Division of Life Sciences, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Comp Biochem Physiol B Biochem Mol Biol 142:201-8. 2005
    ..elucidate the specificity of glucose metabolism in chicken skeletal muscle, changes in mRNA levels of hexokinase I (HKI), hexokinase II (HKII), phosphofructokinase-1 (PFK-1) and glycogen synthase (GS) were characterized in acute and ..
  35. ncbi Mechanism of the Schiff base forming fructose-1,6-bisphosphate aldolase: structural analysis of reaction intermediates
    Esben Lorentzen
    European Molecular Biology Laboratory, Hamburg Outstation, Germany
    Biochemistry 44:4222-9. 2005
    The glycolytic enzyme fructose-1,6-bisphosphate aldolase (FBPA) catalyzes the reversible cleavage of fructose 1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate...
  36. ncbi Taxonomic utility of a phylogenetic analysis of phosphoglycerate kinase proteins of Archaea, Bacteria, and Eukaryota: insights by Bayesian analyses
    J Dennis Pollack
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
    Mol Phylogenet Evol 35:420-30. 2005
    We studied 131 protein sequences of the essentially ubiquitous glycolytic enzyme 3-phosphoglycerate kinase (3-PGK) by Bayesian analyses in three Domains: 15 Archaea, 83 Bacteria, and 33 Eukaryota...
  37. ncbi Comprehensive analysis of the pseudogenes of glycolytic enzymes in vertebrates: the anomalously high number of GAPDH pseudogenes highlights a recent burst of retrotrans-positional activity
    Yuen Jong Liu
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    BMC Genomics 10:480. 2009
    ..One of the glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), has already been noted to have one of the largest numbers of associated pseudogenes, among all proteins...
  38. ncbi Two mechanisms for oxidation of cytosolic NADPH by Kluyveromyces lactis mitochondria
    Karin M Overkamp
    Kluyver Laboratory of Biotechnology, Delft University of Technology, Julianalaan 67, NL 2628 BC Delft, The Netherlands
    Yeast 19:813-24. 2002
    Null mutations in the structural gene encoding phosphoglucose isomerase completely abolish activity of this glycolytic enzyme in Kluyveromyces lactis and Saccharomyces cerevisiae. In S...
  39. ncbi Fodinicola feengrottensis gen. nov., sp. nov., an actinomycete isolated from a medieval mine
    Marc René Carlsohn
    Leibniz Institut für Naturstoff Forschung und Infektionsbiologie e V, Hans Knöll Institut, Beutenbergstrasse 11a, 07745 Jena, Germany
    Int J Syst Evol Microbiol 58:1529-36. 2008
    ..A 16S rRNA gene sequence similarity study indicated that strain HKI 0501(T) forms an individual line of descent and is related to certain members of the suborder Frankineae, order ..
  40. ncbi Spermatogenic cell-specific type 1 hexokinase is the predominant hexokinase in sperm
    Noriko Nakamura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Mol Reprod Dev 75:632-40. 2008
    ..We previously identified three variant transcripts of Hk1 that are expressed specifically in spermatogenic cells, have different 5' untranslated regions, and encode a ..
  41. ncbi Cotransport of glyceraldehyde-3-phosphate dehydrogenase and actin in axons of chicken motoneurons
    A Yuan
    Neuroscience Centre, University of Otago Medical School, Dunedin, New Zealand
    Cell Mol Neurobiol 19:733-44. 1999
    ..mass, pI, amino acid composition, and immunostaining, the unrecognized protein was identified as the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). 3...
  42. ncbi Growth condition-dependent synchronized changes in transcript levels of type II hexokinase and type 1 glucose transporter in tumor cells
    Y Shinohara
    Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1, 770 8505, Tokushima, Japan
    Biochim Biophys Acta 1499:242-8. 2001
    ..In AH130 cells cultured in dishes, HKI and HKII were expressed at a similar level, but HKIII and HKIV were not...
  43. ncbi Effects of ammonium feeding on the production of bioactive metabolites (cordycepin and exopolysaccharides) in mycelial culture of a Cordyceps sinensis fungus
    P H Leung
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    J Appl Microbiol 103:1942-9. 2007
    To examine the effects of ammonium feeding on the production of cordycepin (3'-deoxyadenosine, a nucleoside analogue) and exopolysaccharides (EPS) in mycelial culture of a new Cordyceps sinensis fungus Cs-HK1.
  44. ncbi Sperm from mice carrying two t haplotypes do not possess a tyrosine phosphorylated form of hexokinase
    P Olds-Clarke
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Mol Reprod Dev 43:94-104. 1996
    Mouse sperm contain a tyrosine phosphorylated form of hexokinase type 1 (HK1; Kalab et al., 1994: J Biol Chem 269:3810-3817) that has properties consistent with an integral plasma membrane protein...
  45. ncbi Effect of heart transplantation on skeletal muscle metabolic enzyme reserve and fiber type in end-stage heart failure patients
    Gary L Pierce
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, College of Health and Human Performance, University of Florida, Gainesville, FL, USA
    Clin Transplant 21:94-100. 2007
    ..MHC type I, towards more glycolytic MHC IIx fibers, reductions in oxidative enzyme activity, and increase in glycolytic enzyme activity. However, it is unknown if muscle myopathy is reversed following heart transplantation...
  46. ncbi Structure of a fructose-1,6-bis(phosphate) aldolase liganded to its natural substrate in a cleavage-defective mutant at 2.3 A(,)
    K H Choi
    Structural Biology Group, Department of Physiology, Boston University School of Medicine, 80 East Concord Street, Boston, Massachusetts 02118 2394, USA
    Biochemistry 38:12655-64. 1999
    Class I fructose-1,6-bis(phosphate) aldolase is a glycolytic enzyme that catalyzes the cleavage of fructose 1,6-bis(phosphate) through a covalent Schiff base intermediate...
  47. ncbi Effects of temperature on physiology and reproductive success of a montane leaf beetle: implications for persistence of native populations enduring climate change
    Elizabeth P Dahlhoff
    Department of Biology, Santa Clara University, Santa Clara, California 95053, USA
    Physiol Biochem Zool 81:718-32. 2008
    ..The glycolytic enzyme phosphoglucose isomerase (PGI) is a marker of temperature adaptation in C. aeneicollis...
  48. ncbi Glyceraldehyde-3-phosphate dehydrogenase aggregate formation participates in oxidative stress-induced cell death
    Hidemitsu Nakajima
    Laboratory of Veterinary Pharmacology, Graduate School of Science, Osaka Prefecture University, Izumisano 5988531, Osaka, Japan
    J Biol Chem 284:34331-41. 2009
    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)(2) is a classic glycolytic enzyme that also mediates cell death by its nuclear translocation under oxidative stress...
  49. ncbi The muscle-specific calmodulin-dependent protein kinase assembles with the glycolytic enzyme complex at the sarcoplasmic reticulum and modulates the activity of glyceraldehyde-3-phosphate dehydrogenase in a Ca2+/calmodulin-dependent manner
    Puneet Singh
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 279:35176-82. 2004
    ..Thus, the activation of CaMKIIbeta(M) in response to calcium signaling would serve to modulate GAPDH and thereby ATP and NADH levels at the SR membrane, which in turn will regulate calcium transport processes...
  50. ncbi Activation mechanism of the multifunctional transcription factor repressor-activator protein 1 (Rap1p)
    C M Drazinic
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville 32610 0266, USA
    Mol Cell Biol 16:3187-96. 1996
    ..The upstream activating sequence (UAS) elements of glycolytic enzyme genes in Saccharomyces cerevisiae are excellent model systems for the study of combinatorial interactions...
  51. ncbi Onchocerca volvulus glycolytic enzyme fructose-1,6-bisphosphate aldolase as a target for a protective immune response in humans
    James S McCarthy
    University of Western Australia, Department of Medicine, Fremantle Hospital, Fremantle, Western Australia, Australia
    Infect Immun 70:851-8. 2002
    ..It contained an open reading frame of 363 amino acids encoding the glycolytic enzyme fructose 1,6 bisphosphate aldolase (Ov-fba-1)...
  52. ncbi Reversible nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase upon serum depletion
    H D Schmitz
    Biocentre, Goethe University of Frankfurt, Germany
    Eur J Cell Biol 80:419-27. 2001
    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH; E.C. 1.2.1.12) functions as a glycolytic enzyme within the cytoplasm, but beside its metabolic function it is involved in early steps of apoptosis, which trigger the translocation of GAPDH ..
  53. ncbi Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children
    Rachel Pardes Berger
    Department of Pediatrics, Pittsburgh Child Advocacy Center, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 5213, USA
    Pediatrics 109:E31. 2002
    ..Neuron-specific enolase (NSE) is a glycolytic enzyme that is localized primarily to the neuronal cytoplasm...
  54. ncbi RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism
    Azamat Aslanukov
    Third Wave Technologies, Madison, Wisconsin, United States of America
    PLoS Genet 2:e177. 2006
    ..and in vivo and colocalizes with the mitochondrial metallochaperone, Cox11, and the pacemaker of glycolysis, hexokinase type I (HKI) via its leucine-rich domain...
  55. ncbi Alpha-enolase plasminogen receptor in myogenesis
    Roser Lopez-Alemany
    Institut de Recerca Oncologica, Centre d Oncologia Molecular, L Hospitalet de Llobregat, Barcelona, Spain
    Front Biosci 10:30-6. 2005
    ..Alpha-enolase, although traditionally considered a glycolytic enzyme, constitutes a receptor for plasminogen on several cell types, serving to localize and promote plasminogen ..
  56. ncbi Molecular evolution of the vertebrate hexokinase gene family: Identification of a conserved fifth vertebrate hexokinase gene
    David M Irwin
    Department of Laboratory Medicine and Pathobiology, Banting and Best Diabetes Centre, University of Toronto, Toronto, Canada
    Comp Biochem Physiol Part D Genomics Proteomics 3:96-107. 2008
    ..A total of four hexokinases have been characterized in a diversity of vertebrates-HKI, HKII, HKIII, and HKIV...
  57. ncbi The Treponema pallidum tro operon encodes a multiple metal transporter, a zinc-dependent transcriptional repressor, and a semi-autonomously expressed phosphoglycerate mutase
    Karsten R O Hazlett
    Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, Connecticut 06030 3710, USA
    J Biol Chem 278:20687-94. 2003
    ..tro operon encodes an ABC transporter (TroABCD), a transcriptional repressor (TroR), and the essential glycolytic enzyme phosphoglycerate mutase (Gpm)...
  58. ncbi Mitochondria-associated hexokinases play a role in the control of programmed cell death in Nicotiana benthamiana
    Moonil Kim
    BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Taejon 305 333, Korea
    Plant Cell 18:2341-55. 2006
    ..In this study, virus-induced gene silencing (VIGS) of a hexokinase-encoding Hxk1 caused necrotic lesions on leaves, abnormal leaf morphology, and retarded plant growth in Nicotiana benthamiana...
  59. ncbi Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2
    L Bourgeois
    Laboratory of Enzymology and Protein Chemistry, CNRS EP 117, University Francois Rabelais, 37032 Tours, France
    J Biol Chem 272:29590-5. 1997
    ..They were used to compare the substrate specificities of hK1 and hK2, which both have trypsin-like specificity, and thus differ from chymotrypsin-like hK3...
  60. ncbi The glyceraldehyde-3-phosphate dehydrogenase polypeptides encoded by the Saccharomyces cerevisiae TDH1, TDH2 and TDH3 genes are also cell wall proteins
    M L Delgado
    Departamentos de Microbiología y Ecología, and Bioquímica y Biología Molecular, Universitat de Valencia, Avda Vicent Andres Estelles s n, 46100 Burjasssot Valencia, Spain
    Microbiology 147:411-7. 2001
    The authors show that the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Saccharomyces cerevisiae, previously thought to be restricted to the cell interior, is also present in the cell wall...
  61. ncbi Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate
    Zhao Chen
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Biochim Biophys Acta 1787:553-60. 2009
    ..Hexokinase II (HKII) is a key glycolytic enzyme that plays a role in the regulation of the mitochondria-initiated apoptotic cell death...
  62. ncbi Effects of Tween 80 and pH on mycelial pellets and exopolysaccharide production in liquid culture of a medicinal fungus
    Yuan Shuai Liu
    Department of Applied Biology and Chemical Technology, State Key Laboratory of Chinese Medicine and Molecular Pharmacology in Shenzhen, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    J Ind Microbiol Biotechnol 39:623-8. 2012
    ..and exopolysaccharide (EPS) production in liquid culture of a valuable medicinal fungus Cordyceps sinensis Cs-HK1. In the medium containing 20 g l?¹ glucose and 6 g l?¹ peptone as the sole nitrogen source, the Cs-HK1 fungal ..
  63. ncbi The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks
    Melissa J Caimano
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030 3715, USA
    Infect Immun 79:3117-30. 2011
    ..The other TCS consists of a hybrid histidine kinase, Hk1, and the response regulator Rrp1...
  64. ncbi Novel expression of kallikreins, kallikrein-related peptidases and kinin receptors in human pleural mesothelioma
    Jessica Chee
    Lung Institute of Western Australia, Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Nedlands WA, Australia
    Biol Chem 388:1235-42. 2007
    ..The kallikrein serine proteases [tissue (hK1) and plasma (hKB1) kallikreins, and kallikrein-related peptidases (KRP/hK2-15)] and the mitogenic kinin peptides ..
  65. ncbi Clotrimazole inhibits and modulates heterologous association of the key glycolytic enzyme 6-phosphofructo-1-kinase
    Patricia Zancan
    Laboratório de Enzimologia e Controle do Metabolismo, Departamento de Fármacos, Faculdade de Farmacia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Biochem Pharmacol 73:1520-7. 2007
    ..Here, we show that clotrimazole directly inhibits the key glycolytic enzyme 6-phosphofructo-1-kinase (PFK)...
  66. ncbi Anti-invasion, anti-proliferation and anoikis-sensitization activities of lapatinib in nasopharyngeal carcinoma cells
    Vivian Wai Yan Lui
    Department of Clinical Oncology, Chinese University of Hong Kong, Hong Kong, SAR, Hong Kong
    Invest New Drugs 29:1241-52. 2011
    ..For the most lapatinib-sensitive cell line (HK1-LMP1, with IC(50) ? 600 nM), which harbored the highest levels of both EGFR and HER-2, inhibition of cell growth ..
  67. ncbi Cooperation of Ha-ras and Bcl-2 during multistep skin carcinogenesis
    Sangjun Lee
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Carcinog 46:949-57. 2007
    ..The apoptotic index (AI) following UV-irradiation was significantly lower in HK1.bcl-2 and HKI.ras/bcl-2 epidermis compared to control littermates. Interestingly, the AI of HK1...
  68. ncbi Hypericin photoactivation triggers down-regulation of matrix metalloproteinase-9 expression in well-differentiated human nasopharyngeal cancer cells
    H Y Du
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Cell Mol Life Sci 64:979-88. 2007
    ..study evaluated the expression of matrix metalloproteinase-9 (MMP-9) following hypericin-PDT in well-differentiated HK1 NPC cells...
  69. ncbi Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen and angiogenin interact with common host proteins, including annexin A2, which is essential for survival of latently infected cells
    Nitika Paudel
    H M Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    J Virol 86:1589-607. 2012
    ..It is also known to associate with glycolytic enzyme 3-phosphoglyceratekinase in the primer recognition protein (PRP) complex that interacts with DNA polymerase ?..
  70. ncbi Predicting the melting point of human C-type lysozyme mutants
    Deeptak Verma
    Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC 28223, USA
    Curr Protein Pept Sci 11:562-72. 2010
    ..The glycolytic enzyme lysozyme is among the most well characterized proteins under this paradigm, due to its abundance and ease of ..
  71. ncbi HXK1 regulates carbon catabolism, sporulation, fumonisin B? production and pathogenesis in Fusarium verticillioides
    Hun Kim
    Department of Plant Pathology, University of Arkansas, Fayetteville, AR 72701, USA
    Microbiology 157:2658-69. 2011
    ..In this study, we investigated the role of a putative hexokinase-encoding gene (HXK1) in growth, development and pathogenesis...
  72. ncbi Transgenic rescue of hemolytic anemia due to red blood cell pyruvate kinase deficiency
    Hitoshi Kanno
    Department of Transfusion Medicine and Cell Processing, Tokyo Women s Medical University, Tokyo, Japan
    Haematologica 92:731-7. 2007
    Red blood cell pyruvate kinase (R-PK) deficiency is the most common glycolytic enzyme defect associated with hereditary non-spherocytic hemolytic anemia...
  73. ncbi Kinetics of transport and phosphorylation of glucose in cancer cells
    Sara Rodriguez-Enriquez
    Departamento de Bioquimica, Instituto Nacional de Cardiologia Ignacio Chavez, Tlalpan, Mexico City, Mexico
    J Cell Physiol 221:552-9. 2009
    ..why they are the main controlling steps, the GLUT and HK kinetics and the contents of GLUT1, GLUT2, GLUT3, GLUT4, HKI, and HKII were analyzed in rat hepatocarcinoma AS-30D and HeLa human cervix cancer...
  74. ncbi The development of HKI-272 and related compounds for the treatment of cancer
    Allan Wissner
    Chemical and Screening Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, USA
    Arch Pharm (Weinheim) 341:465-77. 2008
    The development of HKI-272 and EKB-569 for the treatment of cancer is described. These compounds function as irreversible inhibitors of some members of the ErbB family of receptor tyrosine kinases...
  75. ncbi Expression and evolutionary features of the hexokinase gene family in Arabidopsis
    Abhijit Karve
    Department of Genetics and Biochemistry, Clemson University, Clemson, SC, 29634, USA
    Planta 228:411-25. 2008
    Arabidopsis hexokinase1 (HXK1) is a moonlighting protein that has separable functions in glucose signaling and in glucose metabolism...
  76. ncbi Glycolytic enzyme expression in human granulosa cells
    David John Gillott
    The London Bridge Fertility, Gynaecology and Genetics Centre, London Bridge, United Kingdom
    Fertil Steril 90:1405-10. 2008
    ..To examine the differences in specific protein expression between mural and cumulus granulosa cells following 24-hour in vitro culture...
  77. ncbi Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Blood 113:5588-98. 2009
    ..The glycolytic enzyme enolase-1 (ENO-1) binds plasminogen at the cell surface, enhancing local plasmin production...
  78. ncbi Detection of neuron-specific gamma-enolase messenger ribonucleic acid in normal human leukocytes by polymerase chain reaction amplification with nested primers
    H Pechumer
    Pediatric Outpatient Clinic, University of Munich, Germany
    Lab Invest 69:743-9. 1993
    NNE (non-neuronal alpha-enolase) is a glycolytic enzyme detected in most tissues. NSE (neuron-specific gamma-enolase) is detected in normal neurons and tumors such as neuroblastoma...
  79. ncbi ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver
    Pierre Damien Denechaud
    Institut Cochin, Departement d Endocrinologie, Métabolisme et Cancer, Universite Paris Descartes, CNRS, UMR 8104, Paris, France
    J Clin Invest 118:956-64. 2008
    ..a central regulator of lipid synthesis in liver because it is required for glucose-induced expression of the glycolytic enzyme liver-pyruvate kinase (L-PK) and acts in synergy with SREBP to induce lipogenic genes such as acetyl-CoA ..
  80. ncbi Charge stabilization and entropy reduction of central lysine residues in fructose-bisphosphate aldolase
    Miguel St-Jean
    Déepartement de Biochimie, Universite de Montreal, Quebec H3C 3J7, Canada
    Biochemistry 48:4528-37. 2009
    Fructose-1,6-bisphosphate muscle aldolase is an essential glycolytic enzyme that catalyzes reversible carbon-carbon bond formation by cleaving fructose 1,6-bisphosphate to yield dihydroxyacetone phosphate (DHAP) and d-glyceraldehyde ..
  81. ncbi Human H+ATPase a4 subunit mutations causing renal tubular acidosis reveal a role for interaction with phosphofructokinase-1
    Ya Su
    Department of Medical Genetics, Cambridge University, Cambridge Institute for Medical Research, Addenbrooke s Hospital Box 139, Cambridge, CB2 0XY, UK
    Am J Physiol Renal Physiol 295:F950-8. 2008
    ..Both lie within a domain that binds the glycolytic enzyme phosphofructokinase-1 (PFK-1)...
  82. ncbi Puf1p acts in combination with other yeast Puf proteins to control mRNA stability
    Randi J Ulbricht
    Department of Biology, University of Missouri St Louis, St Louis, Missouri 63121, USA
    RNA 14:246-62. 2008
    ..of nearly 40 candidate mRNAs, we established two of these as true mRNA targets of Puf-mediated decay in yeast, HXK1 and TIF1. In a novel finding, multiple Puf proteins, including Puf1p, regulate both of these mRNAs in combination...
  83. ncbi The activity of mTOR inhibitor RAD001 (everolimus) in nasopharyngeal carcinoma and cisplatin-resistant cell lines
    Brigette B Y Ma
    State Key Laboratory in Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Cancer Drug Testing Unit, Hong Kong Cancer Institute, Chinese University of Hong Kong, Shatin, Hong Kong
    Invest New Drugs 28:413-20. 2010
    ..the activity of an mTOR inhibitor, RAD001 (Everolimus, Novartis Pharma AG, Switzerland), in 5 NPC cell lines (HK1, HONE-1, CNE-1, CNE-2, C666-1), 2 cisplatin-resistant NPC cell lines and their respective parental cell lines (HK1-..
  84. ncbi Deletion of the gene encoding the glycolytic enzyme triosephosphate isomerase (tpi) alters morphology of Salmonella enterica serovar Typhimurium and decreases fitness in mice
    Gavin K Paterson
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    FEMS Microbiol Lett 294:45-51. 2009
    The glycolytic enzyme triosephosphate isomerase (tpi) (EC 5.3.1...
  85. ncbi Sleep, aging, and lifespan in Drosophila
    Daniel Bushey
    Dept of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    BMC Neurosci 11:56. 2010
    ..Also, sleep quality has been shown to decrease in old flies, but it remains unclear whether aging-related sleep fragmentation is a generalized phenomenon...
  86. ncbi First mutation in the red blood cell-specific promoter of hexokinase combined with a novel missense mutation causes hexokinase deficiency and mild chronic hemolysis
    Karen M K de Vooght
    Department of Clinical Chemistry and Hematology, Laboratory for Red Blood Cell Research, University Medical Center Utrecht, The Netherlands
    Haematologica 94:1203-10. 2009
    ..Red blood cell-specific hexokinase is transcribed from HK1 by use of an erythroid-specific promoter...
  87. ncbi Kribbella aluminosa sp. nov., isolated from a medieval alum slate mine
    Marc René Carlsohn
    Leibniz Institut für Naturstoff Forschung und Infektionsbiologie e V, Hans Knöll Institut, 07745 Jena, Germany
    Int J Syst Evol Microbiol 57:1943-7. 2007
    Three actinomycetes (strains HKI 0478(T), HKI 0479 and HKI 0480) isolated from the surfaces of rocks in the Feengrotten medieval alum slate mine (Thuringia, Germany) were examined in a polyphasic taxonomic study...
  88. ncbi HKI-272 in non small cell lung cancer
    KWOK KIN WONG
    Department of Medical Oncology, Dana Farber Cancer Institute, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Cancer Res 13:s4593-6. 2007
    ..b>HKI-272 is an irreversible EGFR/HER/ErbB inhibitor that has been shown to inhibit the growth of T790M mutant cells in ..
  89. ncbi 2-[18F]-2-deoxy-D-glucose (FDG) uptake in human tumor cells is related to the expression of GLUT-1 and hexokinase II
    L C Ong
    Singapore General Hospital, Singapore National Cancer Centre, Singapore
    Acta Radiol 49:1145-53. 2008
    ..Many tumors have been shown to overexpress facilitated glucose transporters, especially GLUT-1 and a glycolytic enzyme, hexokinase II.
  90. ncbi Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene
    J Lytton
    Banting and Best Department of Medical Research, C H Best Institute, University of Toronto, Ontario, Canada
    J Biol Chem 263:15024-31. 1988
    ..The human kidney cDNAs, HK1 and HK2, are the products of alternative splicing...
  91. ncbi Determination of pyruvate kinase type tumor M2 in human renal cell carcinoma: a suitable tumor marker?
    Z Varga
    Department of Urology, Philipps University, Marburg, Germany
    Urol Res 30:122-5. 2002
    Renal cell carcinoma (RCC) expresses an isoform of the glycolytic enzyme pyruvate kinase (type M2)...
  92. ncbi Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy
    Hongyan Du
    Department of Anatomy, National University of Singapore, Singapore
    Int J Mol Med 10:73-6. 2002
    ..b>HK1 and CNE-2...
  93. ncbi Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex
    S Mazurek
    Institute for Biochemistry and Endocrinology, Veterinary Faculty, University of Giessen, Frankfurter Strasse 100, D 35392 Giessen, Germany
    Biochem J 356:247-56. 2001
    ..In both NIH 3T3 cell lines, transformation increased glutaminolysis and the positive correlation between alanine and lactate production...
  94. ncbi The hexokinase 2 protein regulates the expression of the GLK1, HXK1 and HXK2 genes of Saccharomyces cerevisiae
    A Rodriguez
    Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Biotecnologia de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain
    Biochem J 355:625-31. 2001
    ..source, the HXK2 gene is repressed and the HXK1 and GLK1 genes are rapidly de-repressed, producing the enzymes hexokinase 1 (Hxk1p) and glucokinase (Glk1p) respectively...
  95. ncbi [Tumor M2 pyruvate kinase in renal cell carcinoma. Studies of plasma in patients]
    J Roigas
    Klinik und Poliklinik fur Urologie, Campus Mitte, Universitatsklinikum Charite, Humboldt Universitat zu Berlin
    Urologe A 39:554-6. 2000
    ..The metabolic differences require changes in glycolytic enzyme activities and isoenzyme patterns...
  96. ncbi Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young
    S Yamada
    Department of Cell Biology, Gunma University, Japan
    Diabetologia 43:121-4. 2000
    ..These genes and the gene encoding glycolytic enzyme glucokinase (MODY2) are, however, responsible for only 15-20% of cases of MODY in the Japanese...
  97. ncbi Activation of the gene encoding the glycolytic enzyme beta-enolase during early myogenesis precedes an increased expression during fetal muscle development
    A Keller
    Laboratoire de Biochimie Cellulaire, CNRS URA 1115, College de France, Paris
    Mech Dev 38:41-54. 1992
    We define the spatial and temporal patterns of expression of the gene encoding the glycolytic enzyme, beta-enolase, during mouse ontogenesis. Transcripts were detected by in situ hybridization using 35S labelled cRNA probes...
  98. ncbi A novel NH(2)-terminal, nonhydrophobic motif targets a male germ cell-specific hexokinase to the endoplasmic reticulum and plasma membrane
    A J Travis
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6142, USA
    J Biol Chem 274:34467-75. 1999
    Although three germ cell-specific transcripts of type 1 hexokinase exist in murine male germ cells, only one form, HK1-sc, is found at the protein level...
  99. ncbi Human HKR isozyme: organization of the hexokinase I gene, the erythroid-specific promoter, and transcription initiation site
    K Murakami
    Division of Pediatric Hematology, Columbia University College of Physicians and Surgeons, New York 10032, USA
    Mol Genet Metab 67:118-30. 1999
    We previously described a cDNA for the human HKR isozyme, whose sequence is identical to that of the ubiquitous HKI isozyme, except for a unique 5' end sequence...
  100. ncbi Structure of the human hexokinase type I gene and nucleotide sequence of the 5' flanking region
    A Ruzzo
    G Fornaini Institute of Biological Chemistry, University of Urbino, Via Saffi 2, 61029 Urbino, Italy
    Biochem J 331:607-13. 1998
    This study reports the precise intron/exon boundaries and intron/exon composition of the human hexokinase type I gene...
  101. ncbi NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase from Thermoproteus tenax. The first identified archaeal member of the aldehyde dehydrogenase superfamily is a glycolytic enzyme with unusual regulatory properties
    N A Brunner
    Department of Microbiology, FB 9, Universit t GH Essen, Universit tsstrasse 5, 45117 Essen, Germany
    J Biol Chem 273:6149-56. 1998
    ..tenax. Its regulatory properties substitute for those lacking in the reversible nonregulated pyrophosphate-dependent phosphofructokinase in this variant of the Embden-Meyerhof-Parnas pathway...

Research Grants88

  1. REGULATORY ENZYMES OF GLYCOLYSIS AND GLUCONEOGENESIS
    HERBERT FROMM; Fiscal Year: 1993
    ..questions by investigation of two highly regulated enzymes of carbohydrate metabolism, human brain hexokinase (HKI) and porcine liver fructose-1, 6- bisphosphatase (FBPase)...
  2. Glycolysis and Glutamate Storage into Synaptic Vesicles
    Tetsufumi Ueda; Fiscal Year: 2007
    ..More recently we have obtained preliminary evidence that pyruvate kinase (PK), another glycolytic enzyme capable of ATP synthesis, is also bound to synaptic vesicles, and that activation of this enzyme leads to ..
  3. Glycolysis and Glutamate Storage into Synaptic Vesicles
    Tetsufumi Ueda; Fiscal Year: 2010
    ..More recently we have obtained preliminary evidence that pyruvate kinase (PK), another glycolytic enzyme capable of ATP synthesis, is also bound to synaptic vesicles, and that activation of this enzyme leads to ..
  4. HORMONAL CONTROL OF HEPATIC GLUCONEOGENESIS/GLYCOLYSIS
    Alex Lange; Fiscal Year: 2005
    ..High levels of fructose-2,6-bisphosphate allosterically activate the glycolytic enzyme 6-phosphofructo-1-kinase and inhibit the gluconeogenic enzyme fructose-1,6-bisphosphatase, thereby ..
  5. CORNEAL STROMAL-EPITHELIAL INTERACTIONS DURING REPAIR
    JAMES ZIESKE; Fiscal Year: 1993
    ..In the last four years, a component of focal contacts; alpha-enolase, a glycolytic enzyme; and epidermal growth factor (EGF) receptor were found in higher concentrations in the epithelium during ..
  6. HEXOKINASE II--STRUCTURE, REGULATION AND FUNCTION
    DARYL GRANNER; Fiscal Year: 2002
    ..There are four major hexokinases (HKI-IV) in mammalian cells...
  7. HEXOKINASE II--STRUCTURE, REGULATION AND FUNCTION
    DARYL GRANNER; Fiscal Year: 1993
    ..The major focus of the proposal is on hexoskinase II (HKII) which, like HKI and HKIII is a 100 kD isoform that is inhibited by physiologic concentrations of G-6-P...
  8. Genetic Dissection of Age-dependent Neuroprotection Mechanisms in Drosophila
    BARRY S GANETZKY; Fiscal Year: 2010
    ..wstd encodes the glycolytic enzyme, triose phosphate isomerase (Tpi) responsible for the interconversion of DHAP (dihydroxyacetone phosphate) ..
  9. High Throughput Screening to Identify Inhibitors of a Fifth Mammalian Hexokinase
    Jeffrey Johnson; Fiscal Year: 2007
    ..members of the hexokinase family (76% amino acid sequence identity and similar domain structure between HKDC1 and HK1), especially in the putative ATP-binding domain, great care must be taken to ensure the specificity of the ..
  10. Identification of Inhibitors of Trypanosoma Brucei Hexokinases
    James Morris; Fiscal Year: 2007
    ..brucei, as the pathway is essential. Inhibitors of hexokinase (TbHK), a key glycolytic enzyme, have been shown to be toxic to trypanosomes...
  11. Glucose Signaling in Plants
    Jen Sheen; Fiscal Year: 2009
    ..in the model plant Arabidopsis thaliana has provided compelling genetic and biochemical evidence that hexokinase1 (HXK1) is an evolutionarily conserved glucose sensor that integrates nutrient and hormone signals to govern gene ..
  12. Glucose Signaling in Plants
    Jen Sheen; Fiscal Year: 2010
    ..in the model plant Arabidopsis thaliana has provided compelling genetic and biochemical evidence that hexokinase1 (HXK1) is an evolutionarily conserved glucose sensor that integrates nutrient and hormone signals to govern gene ..
  13. Glucose energy metabolism in the growth and survival of B lymphocytes
    THOMAS CHILES; Fiscal Year: 2009
    ..Our results suggest that the rate-limiting glycolytic enzyme, phosphofructokinase-1 (PFK-1) is inhibited following Fc?RIIB engagement...
  14. Glucose energy metabolism in the growth and survival of B lymphocytes
    THOMAS CRANE CHILES; Fiscal Year: 2010
    ..Our results suggest that the rate-limiting glycolytic enzyme, phosphofructokinase-1 (PFK-1) is inhibited following Fc?RIIB engagement...
  15. Type-1 Diabetes: Zn2+ Potentiated Beta-Cell Death By Sirtuin-Mediated NAD+ Loss
    CHRISTIAN THOMAS SHELINE; Fiscal Year: 2010
    ..Mitochondrial and glycolytic enzyme dysfunction, pyridine cofactor and triosephosphate imbalance, and poly-ADP ribose polymerase (PARP) ..
  16. Type-1 Diabetes: Zn2+ Potentiated Beta-Cell Death By
    Christian Sheline; Fiscal Year: 2006
    ..Mitochondrial and glycolytic enzyme dysfunction, pyridine cofactor and triosephosphate imbalance, and poly-ADP ribose polymerase (PARP) ..
  17. Type-1 Diabetes: Zn2+ Potentiated Beta-Cell Death By Sirtuin-Mediated NAD+ Loss
    CHRISTIAN THOMAS SHELINE; Fiscal Year: 2010
    ..Mitochondrial and glycolytic enzyme dysfunction, pyridine cofactor and triosephosphate imbalance, and poly-ADP ribose polymerase (PARP) ..
  18. Type-1 Diabetes: Zn2+ Potentiated Beta-Cell Death By Sirtuin-Mediated NAD+ Loss
    Christian Sheline; Fiscal Year: 2007
    ..Mitochondrial and glycolytic enzyme dysfunction, pyridine cofactor and triosephosphate imbalance, and poly-ADP ribose polymerase (PARP) ..
  19. Type-1 Diabetes: Zn2+ Potentiated Beta-Cell Death By Sirtuin-Mediated NAD+ Loss
    Christian Sheline; Fiscal Year: 2009
    ..Mitochondrial and glycolytic enzyme dysfunction, pyridine cofactor and triosephosphate imbalance, and poly-ADP ribose polymerase (PARP) ..
  20. LISST
    David Sullivan; Fiscal Year: 2002
    This research program has as its goal understanding the structural basis for glycolytic enzyme co-localization and targeting at Z-discs and M- lines of the sarcomere as a means of understanding how this essential aspect of glycolytic ..
  21. PRO-APOPTOTIC GAPDH NUCLEAR ACCUMULATION AND RETINAL CELL DEATH
    E CHEPCHUMBA YEGO; Fiscal Year: 2007
    ..Nuclear accumulation of the glycolytic enzyme, glyceraldehyde-3- phosphate dehydrogenase (GAPDH), a cytosolic enzyme is an early pro-apoptotic event...
  22. NEUROPROTECTIVE GENE INDUCTION BY ANTIOXIDANT IRON CHELA
    Rajiv Ratan; Fiscal Year: 2002
    ..The increase in glycolytic enzyme activity induced by iron chelators could be abrogated by actinomycin-D, an mRNA synthase inhibitor, ..
  23. Glucose Signal Transduction Pathways in Plants
    Jen Sheen; Fiscal Year: 2007
    ..Aim 2. Proteomic and genetic analysis of the HXK1 protein complexes in glucose signaling...
  24. DISSECTION OF STRESS SIGNALING PATHWAYS TO A MAP KINASE
    Kazuhiro Shiozaki; Fiscal Year: 2007
    ..with Wis4 and Win1; (II) to uncover how oxidative stress signaling to the SAPK cascade is mediated by a glycolytic enzyme, GAPDH, which has unexpectedly been found as a component of the MAPKKK complex; and (iii) to determine how ..