GRINL1A

Summary

Gene Symbol: GRINL1A
Description: glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
Alias: DKFZp586F1918, GRINL1A downstream protein Gdown4, OTTHUMP00000163345, OTTHUMP00000163421, protein GRINL1A, protein GRINL1A, isoforms 4/5
Species: human

Publications

  1. ncbi Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A
    María F García-Mayoral
    Departamento de Espectroscopía y Estructura Molecular, Instituto de Quimica Fisica Rocasolano, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    FEBS J 277:2340-50. 2010
  2. ncbi GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity
    Raymond S Roginski
    Department of Anesthesiology and Critical Care, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroreport 19:1721-6. 2008
  3. ncbi A genome-wide association study of hypertension and blood pressure in African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    PLoS Genet 5:e1000564. 2009
  4. ncbi A quantitative atlas of mitotic phosphorylation
    Noah Dephoure
    Department of Cell Biology, Harvard University Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:10762-7. 2008
  5. ncbi Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease
    C P Jacob
    Clinical Neurochemistry and National Parkinson Foundation Centre of Excellence Research Laboratories, Clinic and Policlinic for Psychiatry and Psychotherapy, University of Wurzburg, Germany
    J Alzheimers Dis 11:97-116. 2007
  6. ncbi Diversity of translation start sites may define increased complexity of the human short ORFeome
    Masaaki Oyama
    Medical Proteomics Laboratory, University of Tokyo, Japan
    Mol Cell Proteomics 6:1000-6. 2007
  7. ncbi A Mediator-responsive form of metazoan RNA polymerase II
    Xiaopeng Hu
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:9506-11. 2006
  8. ncbi Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia
    Barbara Ann Guinn
    Department of Haematological Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, The Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, UK
    Biochem Biophys Res Commun 335:1293-304. 2005
  9. ncbi The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes
    Raymond S Roginski
    Department of Anesthesia, University of Pennsylvania School of Medicine, 336 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Genomics 84:265-76. 2004
  10. ncbi Assignment of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1 by in situ hybridization
    R S Roginski
    Department of Anesthesiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 125 Paterson Street, New Brunswick, NJ 08901, USA
    Cytogenet Cell Genet 93:143-4. 2001

Scientific Experts

  • R S Roginski
  • Barbara Guinn
  • D Ebert
  • Masaaki Oyama
  • A Adeyemo
  • María F García-Mayoral
  • Noah Dephoure
  • C P Jacob
  • Xiaopeng Hu
  • Juan P Albar
  • Ignacio Rodriguez-Crespo
  • Mónica Martínez-Moreno
  • Marta Bruix
  • Stephen J Elledge
  • Corey E Bakalarski
  • Sean A Beausoleil
  • Chunshui Zhou
  • Steven P Gygi
  • Judit Villen
  • N Zander
  • J Bartl
  • E Grunblatt
  • E Neuen-Jacob
  • P Riederer
  • T Arzberger
  • W Roggendorf
  • E Koutsilieri
  • R Ravid
  • Jennifer Catalano
  • Costin Catalin Negroiu
  • Brian Hampton
  • Averell Gnatt
  • Kyle Hubbard
  • Chidambaram Natesa Velalar
  • Dan Grosu
  • Robert G Roeder
  • Sohail Malik

Detail Information

Publications10

  1. ncbi Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A
    María F García-Mayoral
    Departamento de Espectroscopía y Estructura Molecular, Instituto de Quimica Fisica Rocasolano, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    FEBS J 277:2340-50. 2010
    ..Using DYNLL1 as bait in a yeast two-hybrid screen with a human heart library, we identified GRINL1A (ionotropic glutamate receptor N-methyl-D-aspartate-like 1A), a homolog of the ionotropic glutamate receptor N-..
  2. ncbi GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity
    Raymond S Roginski
    Department of Anesthesiology and Critical Care, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroreport 19:1721-6. 2008
    We hypothesized that proteins from the GRINL1A complex transcription unit called Gcom proteins modulate glutamatergic neurotransmission through interaction with the NR1 subunit of the N-methyl D-aspartate (NMDA) receptor...
  3. ncbi A genome-wide association study of hypertension and blood pressure in African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    PLoS Genet 5:e1000564. 2009
    ....
  4. ncbi A quantitative atlas of mitotic phosphorylation
    Noah Dephoure
    Department of Cell Biology, Harvard University Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:10762-7. 2008
    ..Analysis of non-proline site-containing phosphopeptides identified two unique motifs that suggest there are at least two undiscovered mitotic kinases...
  5. ncbi Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease
    C P Jacob
    Clinical Neurochemistry and National Parkinson Foundation Centre of Excellence Research Laboratories, Clinic and Policlinic for Psychiatry and Psychotherapy, University of Wurzburg, Germany
    J Alzheimers Dis 11:97-116. 2007
    ..Moreover, there were down-regulations of other glutamatergic receptors such as NMDA (GRINL1A) and AMPA (GRIA4) receptors...
  6. ncbi Diversity of translation start sites may define increased complexity of the human short ORFeome
    Masaaki Oyama
    Medical Proteomics Laboratory, University of Tokyo, Japan
    Mol Cell Proteomics 6:1000-6. 2007
    ..Protein expression analysis of the GRINL1A gene revealed that translation from the most upstream start site occurred on the minor alternative splicing ..
  7. ncbi A Mediator-responsive form of metazoan RNA polymerase II
    Xiaopeng Hu
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:9506-11. 2006
    ..Our results reveal a transcriptional control mechanism in which Mediator-dependent regulation is enforced by means of Gdown1, which likely restricts Pol II function only to be reversed by Mediator...
  8. ncbi Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia
    Barbara Ann Guinn
    Department of Haematological Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, The Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, UK
    Biochem Biophys Res Commun 335:1293-304. 2005
    ..in patient bone marrow (BM) and peripheral blood (PB) but not in normal donor samples (PASD1, SSX2IP, and GRINL1A). Real-time PCR (RQ-PCR) confirmed the restricted expression of PASD1 in normal donor organs...
  9. ncbi The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes
    Raymond S Roginski
    Department of Anesthesia, University of Pennsylvania School of Medicine, 336 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Genomics 84:265-76. 2004
    Sequencing of genomic DNA and cloned transcripts from the 200-kb human GRINL1A gene on chromosome 15 revealed a complex gene structure comprising at least 28 exons. In one gene model, transcription begins at exon 1 and ends at exon 15b...
  10. ncbi Assignment of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1 by in situ hybridization
    R S Roginski
    Department of Anesthesiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 125 Paterson Street, New Brunswick, NJ 08901, USA
    Cytogenet Cell Genet 93:143-4. 2001