GRB7

Summary

Gene Symbol: GRB7
Description: growth factor receptor-bound protein 7
Alias: B47, GRB7 adapter protein, epidermal growth factor receptor GRB-7
Species: human

Top Publications

  1. ncbi Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation
    Sharareh Siamakpour-Reihani
    Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA
    J Mol Recognit 24:314-21. 2011
  2. ncbi High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains
    B Margolis
    Department of Pharmacology, New York University Medical Center, NY 10016
    Proc Natl Acad Sci U S A 89:8894-8. 1992
  3. ncbi GRB-7 facilitates HER-2/Neu-mediated signal transduction and tumor formation
    Tao Bai
    Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland VA Medical Center, Portland, OR 97239, USA
    Carcinogenesis 29:473-9. 2008
  4. ncbi Association of focal adhesion kinase with Grb7 and its role in cell migration
    D C Han
    Cancer Biology Laboratories, Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 274:24425-30. 1999
  5. ncbi Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7
    Stephanie C Pero
    Department of Surgery and the Vermont Cancer Center, University of Vermont School of Medicine, Burlington, Vermont 05405, USA
    J Biol Chem 277:11918-26. 2002
  6. ncbi The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions
    D C Han
    Cancer Biology Laboratories, Department of Molecular Medicine, Cornell University, Ithaca, New York, NY 14853, USA
    Oncogene 20:6315-21. 2001
  7. ncbi Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors
    K Yokote
    Ludwig Institute for Cancer Research, Biomedical Center, S 751 24 Uppsala, Sweden
    J Biol Chem 271:30942-9. 1996
  8. ncbi Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration
    D C Han
    Cancer Biology Laboratories, Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 275:28911-7. 2000
  9. ncbi Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette
    H Lee
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Endocrinol 14:1750-75. 2000
  10. ncbi Specific peptide ligand for Grb7 signal transduction protein and pancreatic cancer metastasis
    Shinji Tanaka
    Department of Hepato Biliary Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    J Natl Cancer Inst 98:491-8. 2006

Research Grants

  1. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara Miller; Fiscal Year: 2006
  2. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION BY INTEGRINS
    Jun Lin Guan; Fiscal Year: 2004
  3. Molecular Analysis of Signal Transduction in Cell Migration
    Jun Lin Guan; Fiscal Year: 2009
  4. Molecular Analysis of Signal Transduction in Cell Migration
    Jun Lin Guan; Fiscal Year: 2006
  5. TARGETING BREAST CANCER WITH SMALL LIGANDS
    David Krag; Fiscal Year: 2006
  6. Light Activation of Retinal Insulin Receptor Signaling
    RAJU RAJALA; Fiscal Year: 2007
  7. Light Activation of Retinal Insulin Receptor Signaling
    RAJU RAJALA; Fiscal Year: 2009
  8. Light Activation of Retinal Insulin Receptor Signaling
    RAJU VS RAJALA; Fiscal Year: 2010
  9. INSULIN RECEPTOR SIGNALING IN THE RETINA
    RAJU RAJALA; Fiscal Year: 2002
  10. EASTERN COOPERATIVE ONCOLOGY GROUP
    Joseph Sparano; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications111 found, 100 shown here

  1. ncbi Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation
    Sharareh Siamakpour-Reihani
    Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA
    J Mol Recognit 24:314-21. 2011
    Adaptor proteins mediate signal transduction from cell surface receptors to downstream signaling pathways. The Grb7 protein family of adaptor proteins is constituted by Grb7, Grb10, and Grb14...
  2. ncbi High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains
    B Margolis
    Department of Pharmacology, New York University Medical Center, NY 10016
    Proc Natl Acad Sci U S A 89:8894-8. 1992
    ..Use of this expression/cloning system should increase our ability to identify downstream modulators of growth factor action...
  3. ncbi GRB-7 facilitates HER-2/Neu-mediated signal transduction and tumor formation
    Tao Bai
    Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland VA Medical Center, Portland, OR 97239, USA
    Carcinogenesis 29:473-9. 2008
    ..GRB-7 over-expression therefore plays pivotal roles in activating signal transduction and promoting tumor growth in breast cancer cells with chromosome 17q11-21 amplification...
  4. ncbi Association of focal adhesion kinase with Grb7 and its role in cell migration
    D C Han
    Cancer Biology Laboratories, Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 274:24425-30. 1999
    ..b>Grb7 is an Src homology (SH) 2-containing and pleckstrin homology domain-containing molecule, which shares significant ..
  5. ncbi Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7
    Stephanie C Pero
    Department of Surgery and the Vermont Cancer Center, University of Vermont School of Medicine, Burlington, Vermont 05405, USA
    J Biol Chem 277:11918-26. 2002
    b>Grb7 is an adapter-type signaling protein, which is recruited via its SH2 domain to a variety of receptor tyrosine kinases (RTKs), including ErbB2 and ErbB3...
  6. ncbi The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions
    D C Han
    Cancer Biology Laboratories, Department of Molecular Medicine, Cornell University, Ithaca, New York, NY 14853, USA
    Oncogene 20:6315-21. 2001
    b>Grb7 family adaptor molecules consist of Grb7, Grb10 and Grb14, each of which has several splicing variants...
  7. ncbi Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors
    K Yokote
    Ludwig Institute for Cancer Research, Biomedical Center, S 751 24 Uppsala, Sweden
    J Biol Chem 271:30942-9. 1996
    ..b>Grb7 is an SH2 and PH domain-containing molecule that is known to be overexpressed in some breast cancer tissues and ..
  8. ncbi Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration
    D C Han
    Cancer Biology Laboratories, Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 275:28911-7. 2000
    We have previously described Grb7 association with focal adhesion kinase (FAK) and its possible roles in cell migration. In this paper, we investigated the mechanisms by which Grb7 and its association with FAK regulate cell migration...
  9. ncbi Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette
    H Lee
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Endocrinol 14:1750-75. 2000
    ..In support of this hypothesis, we show that phosphorylation of caveolin-1 on tyrosine 14 confers binding to Grb7 (an SH2-domain containing protein) both in vitro and in vivo...
  10. ncbi Specific peptide ligand for Grb7 signal transduction protein and pancreatic cancer metastasis
    Shinji Tanaka
    Department of Hepato Biliary Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    J Natl Cancer Inst 98:491-8. 2006
    ..found that metastasis was strongly associated with the expression of growth factor receptor-bound protein 7 (Grb7), which contains a Src homology 2 (SH2) domain...
  11. ncbi Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3
    R J Fiddes
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Biol Chem 273:7717-24. 1998
    ..In human breast cancer cell lines, co-immunoprecipitation of Grb7 with both receptors was detected upon heregulin stimulation...
  12. ncbi ERBB2 amplifications in esophageal adenocarcinoma
    Peter S Dahlberg
    Department of Surgery, Division of Cardiovascular and Thoracic Surgery, Hennepin County Medical Center, Minneapolis, Minnesota 55455, USA
    Ann Thorac Surg 78:1790-800. 2004
    ....
  13. ncbi Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 337:1-13. 2005
    ..Phosphotyrosine 936, also in the distal kinase domain, binds the adaptor proteins APS, Grb2, and Grb7. Kit has the potential to participate in multiple signal transduction pathways as a result of interaction with ..
  14. ncbi Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14)
    H Lee
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 276:35150-8. 2001
    ..Phosphocaveolin-1 (Tyr(P)-14) localizes within caveolae near focal adhesions and, through its interaction with Grb7, augments anchorage-independent growth and epidermal growth factor-stimulated cell migration...
  15. ncbi Grb10 exceeding the boundaries of a common signaling adapter
    Heimo Riedel
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202 3917, USA
    Front Biosci 9:603-18. 2004
    ..Grb10 isoforms are members of a super family of signaling mediators that includes Grb7, Grb14, and Caenorhabditis elegans MIG-10...
  16. ncbi Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domai
    W He
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 273:6860-7. 1998
    ..resemblance to other known protein interaction domains but is highly conserved among the Grb10-related proteins Grb7 and Grb14. We show that the BPS domain interaction is dependent upon receptor tyrosine kinase activity...
  17. ncbi The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit
    Patrik Wollberg
    Ludwig Institute for Cancer Research, Biomedical Centre, P O Box 595, SE 751 24 Uppsala, Sweden
    Biochem J 370:1033-8. 2003
    ..recently demonstrated that Tyr-936 is an autophosphorylation site involved in binding the adapter proteins Grb2 and Grb7. We could further demonstrate that the critical determinant for binding of APS is the presence of either a leucine ..
  18. ncbi Lipid-protein interactions of growth factor receptor-bound protein 14 in insulin receptor signaling
    Raju V S Rajala
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Biochemistry 44:15461-71. 2005
    ..cDNA library with the cytoplasmic domain of the retinal insulin receptor (IRbeta) identified a member of the Grb7 (growth factor receptor-bound protein 7) gene family, Grb14...
  19. ncbi Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance
    Ton van Agthoven
    Department of Pathology, Cancer Genomics Center, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Clin Oncol 27:542-9. 2009
    ..Here, we explored whether these BCAR genes provide predictive value for tamoxifen resistance and prognostic information for tumor aggressiveness in breast cancer patients...
  20. ncbi The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Neurodegener 4:28. 2009
    ..abstract:..
  21. ncbi Identification of a NPXY motif in growth factor receptor-bound protein 14 (Grb14) and its interaction with the phosphotyrosine-binding (PTB) domain of IRS-1
    Raju V S Rajala
    Department of Cell Biology, University of Oklahoma Health Sciences Center, and Dean A McGee Eye Institute, Oklahoma City, Oklahoma 73104, USA
    Biochemistry 44:7929-35. 2005
    ..retinal cDNA library with the cytoplasmic domain of retinal insulin receptor identified a novel member of the Grb7 gene family, Grb14...
  22. ncbi Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor
    Bai Lin Tan
    Section of Neonatal Perinatal Medicine, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 278:11686-95. 2003
    ..early signaling pathways, including phospholipase C gamma, phosphatidylinositol 3-kinase, Src kinase, Grb2, and Grb7. The role of these pathways in Kit-induced growth, proliferation, or cooperation with Epo-R is not known...
  23. ncbi The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor
    Andrea Vecchione
    Department of Urology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Mol Cell Biol 23:3363-72. 2003
    The adapter protein Grb10 belongs to a superfamily of related proteins, including Grb7, -10, and -14 and Caenorhabditis elegans Mig10...
  24. ncbi Integrated gene copy number and expression microarray analysis of gastric cancer highlights potential target genes
    Samuel Myllykangas
    Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Int J Cancer 123:817-25. 2008
    ..Genes with the highest statistical significance included ERBB2, MUC1, GRB7, PPP1R1B and PPARBP with concomitant changes in copy number and expression...
  25. ncbi Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domain
    Paul J Scharf
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Protein Sci 13:2541-6. 2004
    ..Grb14 is a member of the Grb7 family of proteins, which also includes Grb7 and Grb10...
  26. ncbi Systematic identification of regulatory proteins critical for T-cell activation
    Peter Chu
    Rigel Pharmaceuticals Inc, 1180 Veterans Blvd, South San Francisco, CA 94080, USA
    J Biol 2:21. 2003
    ..Identifying the signaling proteins downstream of TCR activation will help us to understand the regulation of immune responses and will contribute to developing therapeutic agents that target immune regulation...
  27. ncbi Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation
    Corrine J Porter
    School of Biomedical and Chemical Sciences, University of Western Australia, WA 6009, Australia
    BMC Struct Biol 7:58. 2007
    Human growth factor receptor bound protein 7 (Grb7) is an adapter protein that mediates the coupling of tyrosine kinases with their downstream signaling pathways...
  28. ncbi Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer
    Y Nadler
    Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
    Ann Oncol 21:466-73. 2010
    Growth factor receptor-bound protein-7 (Grb7) is an adapter-type signaling protein recruited to various tyrosine kinases, including HER2/neu. Grb7-specific inhibitors are in early development...
  29. ncbi Coamplification and coexpression of GRB7 and ERBB2 is found in high grade intraepithelial neoplasia and in invasive Barrett's carcinoma
    Axel Walch
    Universitatsklinikum Freiburg, Institute of Pathology, Freiburg i Br, Germany
    Int J Cancer 112:747-53. 2004
    The human growth factor receptor-bound protein 7 gene (GRB7), the founding member of a family of adaptor molecules has been shown to regulate cell migration and has been implicated in tumor progression...
  30. ncbi Differential functions of growth factor receptor-bound protein 7 (GRB7) and its variant GRB7v in ovarian carcinogenesis
    Yajun Wang
    Department of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    Clin Cancer Res 16:2529-39. 2010
    Aberrant overexpression of growth factor receptor-bound protein 7 (GRB7) and its variant GRB7v has been found in numerous human cancers...
  31. ncbi Transduced PEP-1-Grb7 fusion protein suppressed LPS-induced COX-2 expression
    Jae Jin An
    Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Korea
    J Biochem Mol Biol 40:189-95. 2007
    ..Recently, we found that the expression of Grb7 protein was markedly decreased in AD patients using proteomic analysis...
  32. ncbi Cloning and characterization of GRB14, a novel member of the GRB7 gene family
    R J Daly
    Cancer Biology Division, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Biol Chem 271:12502-10. 1996
    ..the tyrosine-phosphorylated C terminus of the epidermal growth factor receptor identified a novel member of the GRB7 gene family, designated GRB14...
  33. ncbi Identification and characterization of mouse Erbb2 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:831-5. 2003
    The PPP1R1B-STARD3-TCAP-PNMT-MGC9753-ERBB2-MGC14832-GRB7 locus on human chromosome 17q12 is frequently amplified in human gastric and breast cancer...
  34. ncbi Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma
    S Tanaka
    Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Cell Physiol 183:411-5. 2000
    ..reported the association of tumor cell invasion with expression of growth factor receptor-bound protein 7 (Grb7)...
  35. ncbi Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14
    Veronique Bereziat
    Endocrinologie et Metabolisme, CNRS UPR 1524 Institut Cochin de Genetique Moleculaire, 24 rue du Faubourg Saint Jacques, 75674 Paris Cedex 14, France
    J Biol Chem 277:4845-52. 2002
    Grb14 belongs to the Grb7 family of adapters and was recently identified as a partner of the insulin receptor (IR). Here we show that Grb14 inhibits in vitro IR substrate phosphorylation...
  36. ncbi Dual action of epidermal growth factor: extracellular signal-stimulated nuclear-cytoplasmic export and coordinated translation of selected messenger RNA
    Nien Pei Tsai
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455
    J Cell Biol 188:325-33. 2010
    ..The effect of EGF is mediated by the RNA-binding protein Grb7 (growth factor receptor-bound protein 7), which serves as an adaptor for a specific mRNA-protein export complex and ..
  37. ncbi Identification and characterization of human ZPBP-like gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:399-404. 2003
    PP1R1B-ERBB2-GRB7 locus on human chromo-some 17q12 is frequently amplified in gastric and breast cancer...
  38. ncbi Role for the adaptor protein Grb10 in the activation of Akt
    Thomas Jahn
    Department of Internal Medicine III, Laboratory of Leukemogenesis, Technical University of Munich, Munich, Germany
    Mol Cell Biol 22:979-91. 2002
    Grb10 is a member of the Grb7 family of adapter proteins lacking intrinsic enzymatic function and encodes functional domains including a pleckstrin homology (PH) domain and an SH2 domain...
  39. ncbi Molecular determinants of Grb14-mediated inhibition of insulin signaling
    Diana Goenaga
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique CNRS Unité Mixte de Recherche UMR 8104, Paris, France
    Mol Endocrinol 23:1043-51. 2009
    Grb14 belongs to the Grb7 family of molecular adapters and was identified as an inhibitor of insulin signaling. Grb14 binds to activated insulin receptors (IR) and inhibits their catalytic activity...
  40. ncbi Genomic organization and control of the grb7 gene family
    E Lucas-Fernández
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid Arturo Duperier 4, E 28029 Madrid, Spain
    Curr Genomics 9:60-8. 2008
    b>Grb7 and their related family members Grb10 and Grb14 are adaptor proteins, which participate in the functionality of multiple signal transduction pathways under the control of a variety of activated tyrosine kinase receptors and other ..
  41. ncbi Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity
    Evan G Stein
    Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 278:13257-64. 2003
    b>Grb7, Grb10, and Grb14 are members of a distinct family of adapter proteins that interact with various receptor tyrosine kinases upon receptor activation...
  42. ncbi Identification of a novel promoter and exons of the c-ERBB-2 gene
    M Nezu
    Genetics Division, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo, 104 0045, Japan
    Biochem Biophys Res Commun 258:499-505. 1999
    ..course of studies on the structural characterization of the amplification units, we isolated four cDNA clones, A39, GRB7, C51 and CAB1 with corresponding genes localized on the c-ERBB-2 locus...
  43. ncbi 17q12-21 - the pursuit of targeted therapy in breast cancer
    R W Glynn
    Department of Surgery, Clinical Science Institute, National University of Ireland, Costello Road, Galway, Ireland
    Cancer Treat Rev 36:224-9. 2010
    ....
  44. ncbi Identification and characterization of human DFNA5L, mouse Dfna5l, and rat Dfna5l genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 25:765-70. 2004
    ..an oncogenomic recombination hotspot around the PPP1R1B-STARD3-TCAP-PNMT-PERLD1 (MGC9753)-ERBB2-C17orf37 (MGC14832)-GRB7 locus at human chromosome 17q12...
  45. ncbi Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells
    Rania Kairouz
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Cell Physiol 203:85-93. 2005
    Growth factor receptor bound (Grb)14 is a member of the Grb7 family of src homology (SH)2 domain-containing proteins...
  46. ncbi Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling
    J Graeme Hodgson
    Department of Laboratory Medicine and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, USA
    Cancer Res 65:9695-704. 2005
    ..structural similarity to the human amplicon, resulting in overexpression of at least two of the genes, Erbb2 and Grb7. Chromosome 11 amplicons distal to Erbb2 arise in a model (DB) overexpressing a mutant variant of PyMT (Y315/322F) ..
  47. ncbi A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk
    E Katz
    Breakthrough Research Unit and Division of Pathology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Br J Cancer 103:401-10. 2010
    ..C35 (C17orf37) is located on the HER2 amplicon, between HER2 and GRB7. The function of over-expressed C35 in invasive breast cancer is unknown.
  48. ncbi NMR analysis of G7-18NATE, a nonphosphorylated cyclic peptide inhibitor of the Grb7 adapter protein
    C J Porter
    School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Perth, WA, Australia
    Biopolymers 88:174-81. 2007
    G7-18NATE is a nonphosphorylated, cyclic peptide that specifically inhibits the Grb7 adapter protein implicated in several pathways critical to cell proliferation and migration...
  49. ncbi EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells
    Pei Yu Chu
    Department of Plant Pathology and Microbiology, National Taiwan University, Taipei 10617, Taiwan
    J Biol Chem 285:29279-85. 2010
    Co-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer...
  50. ncbi Tyrosine phosphorylation of Grb14 by Tie2
    Celina Sturk
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Cell Commun Signal 8:30. 2010
    ..b>Grb7, 10 and 14 are known to become serine and/or threonine phosphorylated in response to growth factor (GF) stimulation...
  51. ncbi Activating mutations and/or expression levels of tyrosine kinase receptors GRB7, RAS, and BRAF in testicular germ cell tumors
    Alan McIntyre
    Molecular Cytogenetics, Section of Molecular Carcinogenesis, The Institute of Cancer Research, Sutton, Surrey, UK
    Neoplasia 7:1047-52. 2005
    ..These receptors can bind the adaptor molecule GRB7 encoded by a gene adjacent to ERBB2 at 17q12, a region also frequently gained in TGCTs...
  52. ncbi Benzopyrazine derivatives: A novel class of growth factor receptor bound protein 7 antagonists
    Nigus D Ambaye
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Victoria 3800, Australia
    Bioorg Med Chem 19:693-701. 2011
    Growth factor receptor bound protein 7 (Grb7) is an adapter protein that functions as a downstream effector of growth factor mediated signal transduction...
  53. ncbi Preparation and crystallization of the Grb7 SH2 domain in complex with the G7-18NATE nonphosphorylated cyclic inhibitor peptide
    Min Y Yap
    Department of Biochemistry and Molecular Biology, School of Chemistry, Monash University, VIC 3800, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:1640-3. 2010
    b>Grb7 is an adapter protein that is involved in signalling pathways that mediate eukaryotic cell proliferation and migration...
  54. ncbi The adapter protein GRB10 is an endogenous negative regulator of insulin-like growth factor signaling
    Aimee M Dufresne
    Endocrinology Division and The Hallett Center for Diabetes and Endocrinology, Rhode Island Hospital, One Hoppin Street, Suite 200, Providence, Rhode Island 02903, USA
    Endocrinology 146:4399-409. 2005
    ..interfering RNA knockdown of Grb10 does not result in increased or decreased expression of the related proteins Grb7 or Grb14...
  55. ncbi Identification of genes with correlated patterns of variations in DNA copy number and gene expression level in gastric cancer
    Sanghwa Yang
    Cancer Metastasis Research Center CMRC, Yonsei University College of Medicine, Seoul 120 752, South Korea
    Genomics 89:451-9. 2007
    ..fibrous histiocytoma amplified sequence 1 (MFHAS1/MASL1), high mobility group AT-hook 2 (HMGA2), PPAR binding protein (PPARBP), growth factor receptor-bound protein 7 (GRB7), and TBC1 (tre-2, BUB2, cdc16) domain family, member 1 (TBC1D1).
  56. ncbi The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner
    Sharareh Siamakpour-Reihani
    Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003 8001, USA
    J Mol Recognit 22:9-17. 2009
    b>Grb7 is an adaptor molecule that can mediate signal transduction from multiple cell surface receptors to various downstream signaling pathways. Grb7, along with Grb10 and Grb14, make up the Grb7 protein family...
  57. ncbi Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan
    Lee H Chen
    Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 6:e28222. 2011
    ..of the initial filtered genes, we developed a prediction model based on the genes SLC22A23, PRKAG3, DPEP3, MORC2, GRB7, and FAM43A. The model had 91.7% accuracy, 81.8% sensitivity, and 94...
  58. ncbi Regulation of stress granule dynamics by Grb7 and FAK signalling pathway
    Nien Pei Tsai
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    EMBO J 27:715-26. 2008
    ..We identified growth factor receptor-bound protein 7 (Grb7), an RNA-binding, translational regulator, as an integral component of SGs, which directly interacts with Hu ..
  59. ncbi Development of binding assays for the SH2 domain of Grb7 and Grb2 using fluorescence polarization
    Jean Philippe Luzy
    INSERM U648, Laboratoire de Pharmacochimie Moleculaire et Cellulaire, UFR Biomedicale, Universite Paris Descartes, Paris, France
    J Biomol Screen 13:112-9. 2008
    Adaptor proteins Grb7 and Grb2 have been implicated as being 2 potential therapeutic targets in several human cancers, especially those that overexpress ErbB2...
  60. ncbi Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression
    Alessio Nencioni
    Department of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
    PLoS ONE 5:e9024. 2010
    ..was used to express constitutively active forms of Akt in the HER2(+) breast cancer cell line SKBR3, and Grb7 in MCF7 cells. Specific gene silencing was obtained by siRNAs transfection...
  61. ncbi Degradation of HER2 by Cbl-based chimeric ubiquitin ligases
    Xia Li
    State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, China
    Cancer Res 67:8716-24. 2007
    ..domain, with the Src homology 2 domain replaced with that from growth factor receptor binding protein 2 (Grb2), Grb7, p85, or Src...
  62. ncbi The intertwining of structure and function: proposed helix-swapping of the SH2 domain of Grb7, a regulatory protein implicated in cancer progression and inflammation
    Sally Pias
    Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico 88003 8001, USA
    Crit Rev Immunol 30:299-304. 2010
    b>Grb7 is a multidomain intracellular signaling protein that links activated tyrosine kinases with downstream signaling targets...
  63. ncbi KIT and RAS signalling pathways in testicular germ cell tumours: new data and a review of the literature
    N C Goddard
    Molecular Cytogenetics, Section of Molecular Carcinogenesis, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Int J Androl 30:337-48; discussion 349. 2007
    ..These, correlations between the expression levels of KIT, KRAS and GRB7 (which encodes an adapter molecule known to interact with the KIT tyrosine kinase receptor) and other reported ..
  64. ncbi Combination treatment with Grb7 peptide and Doxorubicin or Trastuzumab (Herceptin) results in cooperative cell growth inhibition in breast cancer cells
    S C Pero
    Department of Surgery, Vermont Cancer Comprehensive Center, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Br J Cancer 96:1520-5. 2007
    b>Grb7 has potential importance in the progression of cancer. We have previously identified a novel peptide that binds to the SH2 domain of Grb7 and inhibits its association with several different receptor tyrosine kinases...
  65. ncbi Differential modulation of cardiac potassium channels by Grb adaptor proteins
    Oana N Ureche
    Physiologisches Institut 1, University Tuebingen, Tuebingen, Germany
    Biochem Biophys Res Commun 384:28-31. 2009
    ..It is shown that coexpression of Grb adaptor proteins can reduce current amplitudes of coexpressed channels. Grb7 and 10 significantly inhibited functional currents generated by hERG, Kv1.5 and Kv4.3 channels...
  66. ncbi Uptake of a cell permeable G7-18NATE contruct into cells and binding with the Grb-7-SH2 domain
    Nigus D Ambaye
    Department of Biochemistry and Molecular Biology, Monash University, VIC 3800, Australia
    Biopolymers 96:181-8. 2011
    b>Grb7 is an adapter protein found to be overexpressed in several breast and other cancer cell types along with ErbB2...
  67. ncbi Three cases of extranodal NK/T-cell lymphoma of the nasal type diagnosed by nasal brush cytology
    Koji Kishimoto
    Department of Pathology, Showa University Fujigaoka Hospital, Yokohama, Japan
    Diagn Cytopathol 35:125-9. 2007
    ..showed staining for natural killer cell antigen CD56 as well as cytotoxic granule-associated proteins granzyme B7 (GrB7) and T-cell-restricted intercellular antigen-1 (TIA-1)...
  68. ncbi The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation
    Nien Pei Tsai
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    EMBO J 26:1522-31. 2007
    ..We now identify Grb7 as a new RNA-binding protein that serves as the molecular adaptor for transmitting Netrin-1 signals, through focal ..
  69. ncbi The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10
    A Pandey
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109 0602, USA
    J Biol Chem 270:21461-3. 1995
    ..Grb10 belongs to an emerging family of SH2 containing adapter proteins, the prototypical member being Grb7. Using glutathione S-transferase fusion proteins, it was demonstrated that the SH2 domain of Grb10 specifically ..
  70. ncbi The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta
    Bertrand Cariou
    Departement d Endocrinologie, Institut Cochin, CNRS INSERM Université René Descartes 75674 Paris, France
    Mol Cell Biol 22:6959-70. 2002
    Grb14 is a member of the Grb7 family of adapters and acts as a negative regulator of insulin-mediated signaling. Here we found that the protein kinase Czeta (PKCzeta) interacting protein, ZIP, interacted with Grb14...
  71. ncbi EphB1 associates with Grb7 and regulates cell migration
    Dong Cho Han
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 277:45655-61. 2002
    ..b>Grb7 is an adaptor molecule implicated in the regulation of cell migration...
  72. ncbi Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains
    J D Frantz
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 272:2659-67. 1997
    cDNA clones encoding human (h) Grb7 and a previously unknown protein with high homology to hGrb-IR and mGrb10 (where m indicates mouse) were found by screening expressed sequence tag data bases...
  73. ncbi New insights into testicular germ cell tumorigenesis from gene expression profiling
    Rolf I Skotheim
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    Cancer Res 62:2359-64. 2002
    ..The growth factor receptor-bound protein 7 (GRB7) and junction plakoglobin (JUP) were the two most highly overexpressed genes in the TGCTs...
  74. ncbi Investigation of the GRB2, GRB7, and CSH1 genes as candidates for the Silver-Russell syndrome (SRS) on chromosome 17q
    M P Hitchins
    J Med Genet 39:E13. 2002
  75. ncbi Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases
    A Nantel
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council, 6100 Royalmount, Montreal, Quebec H4P 2R2, Canada
    J Biol Chem 273:10475-84. 1998
    Grb10 and its close homologues Grb7 and Grb14, belong to a family of adapter proteins characterized by a proline-rich region, a central PH domain, and a carboxyl-terminal Src homology 2 (SH2) domain...
  76. ncbi Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family
    B Vayssiere
    Unité INSERM 248, Institut Curie, 26 Rue d Ulm, F 75248, Paris, France
    FEBS Lett 467:91-6. 2000
    b>Grb7 is a member of a family of molecular adapters which are able to contribute positively but also negatively to signal transduction and whose precise roles remain obscure...
  77. ncbi Lack of MHC class I surface expression on neoplastic cells and poor activation of the secretory pathway of cytotoxic cells in oral squamous cell carcinomas
    I Cruz
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Br J Cancer 81:881-9. 1999
    ..of CTLs, NK cells, and its activation, was investigated in 21 of these OSCCs using respectively, CD8, CD57 and GrB7 antibodies. The Q-Prodit measuring system was used for quantification of cytotoxic cells...
  78. ncbi Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration
    N Jones
    Division of Cancer Biology Research, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario M4N 3M5
    J Biol Chem 274:30896-905. 1999
    ..Using this approach, we demonstrate that five molecules, Grb2, Grb7, Grb14, Shp2, and the p85 subunit of phosphatidylinositol 3-kinase can interact with Tek in a phosphotyrosine-..
  79. ncbi Expression of Grb7 growth factor receptor signaling protein in kidney development and in adult kidney
    S F Leavey
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0676, USA
    Am J Physiol 275:F770-6. 1998
    b>Grb7, a signaling protein whose physiological function is unknown, binds receptor tyrosine kinases important for normal kidney development...
  80. ncbi The Grb7 family of signalling proteins
    R J Daly
    Cancer Research Program, The Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW, Australia
    Cell Signal 10:613-8. 1998
    The Grb7 family is a rapidly emerging group of Src homology (SH)2 domain-containing signalling proteins that currently contains three members, Grb7, 10 and 14...
  81. ncbi Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma
    L Q Dong
    Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas 78284 7764, USA
    J Biol Chem 272:29104-12. 1997
    ..We have also determined the human chromosome localization of Grb7 to 17q21-q22 and Grb14 to chromosome 2...
  82. ncbi Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer
    T Kishi
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 232:5-9. 1997
    ..We recently isolated four cDNA clones, A39, B47, C51, and CAB1, from 500 kilobases of yeast artificial chromosome DNA containing the c-ERBB-2 gene...
  83. ncbi Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma
    S Tanaka
    Department of Surgery, Kyushu University, Beppu, Japan
    Cancer Res 57:28-31. 1997
    Growth factor receptors transmit intracellular signals that may be important in carcinogenesis. The Grb7 protein was recently identified as a substrate of the epidermal growth factor receptor and related Her2/ erbB2 receptor-linked ..
  84. ncbi The cloning of Grb10 reveals a new family of SH2 domain proteins
    J Ooi
    Department of Pharmacology, New York University Medical Center, NY 10016, USA
    Oncogene 10:1621-30. 1995
    ..Here we report the identification of a new SH2 domain protein, Grb10. Grb10 is highly related to Grb7, an SH2 domain protein that we have previously identified...
  85. ncbi MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:1369-74. 2003
    ..Human MGC9753 gene, consisting of eight exons, were clustered with PPP1R1B, STARD3, TCAP, PNMT, ERBB2, MGC14832 and GRB7 genes within the 120-kb region...
  86. ncbi PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins
    Andrea Jenzora
    Department of Cell Biology, German Research Centre for Biotechnology, 38124 Braunschweig, Germany
    FEBS Lett 579:455-63. 2005
    ..PREL1 is a 74 kDa protein and shares homology with the Grb7-family of signalling adaptors...
  87. ncbi Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 24:757-63. 2004
    PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-MGC14832-GRB7 locus at human chromosome 17q12 is frequently amplified in human gastric cancer and breast cancer. Here, we compared human GSDML-GSDM locus with rodent genomes by using bioinformatics...
  88. ncbi Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays
    Rolf I Skotheim
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Neoplasia 5:397-404. 2003
    ..In a recent transcriptional profiling, we demonstrated the overexpression of GRB7 and JUP in TGCTs, and confirmed the reported overexpression of CCND2...
  89. ncbi The adaptor Grb7 is a novel calmodulin-binding protein: functional implications of the interaction of calmodulin with Grb7
    Hongbing Li
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, c Arturo Duperier 4, Madrid E 28029, Spain
    Oncogene 24:4206-19. 2005
    ..This site is identical in human and rodents Grb7, and shares great homology with similar regions of Grb10 and Grb14, and the Mig10 protein from Caenorhabditis ..
  90. ncbi Altered expression and deletion of RMO1 in osteosarcoma
    Kolja Eppert
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Int J Cancer 114:738-46. 2005
    ..Cloning of RMO1 revealed an open reading frame with multiple splice forms with significant homology to GRB7, 10 and 14 and MIG10 in the region containing a Pleckstrin homology domain and a Ras association domain, suggestive ..
  91. ncbi Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2
    Monika Ivancic
    Department of Biochemistry, University of Vermont College of Medicine Burlington, VT 05405, U S A
    J Biomol NMR 27:205-19. 2003
    ..Close contacts between residues responsible for binding specificity in hGrb7-SH2 and the erbB2 peptide are characterized and the potential effect of mutation of these residues on the hGrb7-SH2 domain structure is discussed...
  92. ncbi Gene expression profiling of neu-induced mammary tumors from transgenic mice reveals genetic and morphological similarities to ErbB2-expressing human breast cancers
    Eran R Andrechek
    Institute for Molecular Biology and Biotechnology, Department of Biology, McMaster University, Hamilton, Canada
    Cancer Res 63:4920-6. 2003
    ..mouse mammary tumor virus-based Neu model, the endogenous promoter tumors expressed elevated levels of two genes (Grb7 and Cab1) that are closely linked to ErbB2 and often coamplified in noninvasive ductal carcinoma in situ...
  93. ncbi Grb10 and Grb14: enigmatic regulators of insulin action--and more?
    Lowenna J Holt
    University of Cambridge, Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge CB2 2QR, UK
    Biochem J 388:393-406. 2005
    The Grb proteins (growth factor receptor-bound proteins) Grb7, Grb10 and Grb14 constitute a family of structurally related multidomain adapters with diverse cellular functions...
  94. ncbi Identification and characterization of LASP2 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:405-10. 2003
    LASP1 (also known as MLN50) gene, located centromeric to the PPP1R1B-ERBB2-GRB7 locus on human chromosome 17q12, is amplified and over-expressed in breast cancer...
  95. ncbi Prognostic value of ERBB family mRNA expression in breast carcinomas
    Ivan Bieche
    Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, St Cloud, France
    Int J Cancer 106:758-65. 2003
    ..several ErbB-specific ligands (amphiregulin and neuregulin 1) and enzymes or adaptor molecules (PI3K, Src, Shc and Grb7) in the ErbB pathway dysregulation associated with breast cancer...
  96. ncbi Grb7-based molecular therapeutics in cancer
    Stephanie C Pero
    Department of Surgery and the Vermont Cancer Center, University of Vermont School of Medicine, Given Medical Building, Burlington, VT 05405, USA
    Expert Rev Mol Med 5:1-11. 2003
    ..b>Grb7 is an adaptor-type signalling protein that is recruited via its Src-homology 2 (SH2) domain to a variety of ..
  97. ncbi NIK is a component of the EGF/heregulin receptor signaling complexes
    Danying Chen
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    Oncogene 22:4348-55. 2003
    ..This effort identified ErbB4, one of the EGF/heregulin receptors, and Grb7, an adapter protein associated with ErbB4 (ErbB, epidermal growth factor receptor family protein; EGF, epidermal ..
  98. ncbi Structural determinants of the interaction between the erbB2 receptor and the Src homology 2 domain of Grb7
    P W Janes
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Biol Chem 272:8490-7. 1997
    The Src homology 2 (SH2) domain-containing protein Grb7 and the erbB2 receptor tyrosine kinase are overexpressed in a subset of human breast cancers. They also co-immunoprecipitate from cell lysates and associate directly in vitro...
  99. ncbi Assignment of backbone 1H, 13C, and 15N resonances of human Grb7-SH2 domain in complex with a phosphorylated peptide ligand
    Peter J Brescia
    J Biomol NMR 23:77-8. 2002
  100. ncbi Grb7-SH2 domain dimerisation is affected by a single point mutation
    Corrine J Porter
    School of Biomedical and Chemical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Eur Biophys J 34:454-60. 2005
    Growth factor receptor bound protein 7 (Grb7) is an adaptor protein that is co-overexpressed and forms a tight complex with the ErbB2 receptor in a number of breast tumours and breast cancer cell lines...
  101. ncbi Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7
    A Pandey
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109 0602, USA
    J Biol Chem 271:10607-10. 1996
    ..A family of SH2 containing adapter proteins including Grb7 and Grb10 has been recently identified...

Research Grants41

  1. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara Miller; Fiscal Year: 2006
    ..in Epo-dependent regulation of TRPC2 will be determined in primary erythroblasts: the adaptor proteins Nck1/2 and Grb7, phospholipase C/inositol 1,4,5 trisphosphate, diacylglycerol, and the G-protein subunit Gi(2...
  2. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION BY INTEGRINS
    Jun Lin Guan; Fiscal Year: 2004
    ..We also found FAK interaction with another adaptor molecule Grb7 and provided evidence of potential function of the interaction in the regulation of cell migration...
  3. Molecular Analysis of Signal Transduction in Cell Migration
    Jun Lin Guan; Fiscal Year: 2009
    ..Previous funding period focused on the role of focal adhesion kinase (FAK) and its downstream target Grb7 and a putative novel FAK inhibitor FIP200 in the regulation of cell migration...
  4. Molecular Analysis of Signal Transduction in Cell Migration
    Jun Lin Guan; Fiscal Year: 2006
    ..Previous funding period focused on the role of focal adhesion kinase (FAK) and its downstream target Grb7 and a putative novel FAK inhibitor FIP200 in the regulation of cell migration...
  5. TARGETING BREAST CANCER WITH SMALL LIGANDS
    David Krag; Fiscal Year: 2006
    ..Therefore, the development of inhibitors against proteins that are overexpressed in breast cancer (e.g. Grb7) will be important in developing improved therapeutics with increased specificity and less toxicity...
  6. Light Activation of Retinal Insulin Receptor Signaling
    RAJU RAJALA; Fiscal Year: 2007
    ..The biological implications extend to the cause and treatment of a number of retinal degenerative diseases. ..
  7. Light Activation of Retinal Insulin Receptor Signaling
    RAJU RAJALA; Fiscal Year: 2009
    ..The biological implications extend to the cause and treatment of a number of retinal degenerative diseases. ..
  8. Light Activation of Retinal Insulin Receptor Signaling
    RAJU VS RAJALA; Fiscal Year: 2010
    ..Studies proposed in this grant application would help to understand the functional roles of IR and IGF-1R in photoreceptor structure, function and survival. ..
  9. INSULIN RECEPTOR SIGNALING IN THE RETINA
    RAJU RAJALA; Fiscal Year: 2002
    ..The biological implication extends to the cause and treatment of a number of retinal degenerative diseases. ..
  10. EASTERN COOPERATIVE ONCOLOGY GROUP
    Joseph Sparano; Fiscal Year: 2006
    ....
  11. BR12 Familial British and Danish Dementias and Alzheimer's Disease
    LUCIANO D ADAMIO; Fiscal Year: 2009
    ..We hope that our studies will translate into a program to develop drug for altering the course of the disease versus simply treating the symptoms like all of the approved drugs for AD currently are. ..
  12. BR12 Familial British and Danish Dementias and Alzheimer's Disease
    LUCIANO D apos ADAMIO; Fiscal Year: 2010
    ..We hope that our studies will translate into a program to develop drug for altering the course of the disease versus simply treating the symptoms like all of the approved drugs for AD currently are. ..
  13. Discovery and characterization of breast cancer genes
    John Hodgson; Fiscal Year: 2007
    ..Finally, effects on in vivo tumorigenic potential will be assessed by evaluating tumor growth in immunedeficient mice. ..
  14. EASTERN COOPERATIVE ONCOLOGY GROUP
    Joseph Sparano; Fiscal Year: 2007
    ....
  15. Cellular signaling and Trafficking of APP Family Members
    LUCIANO D ADAMIO; Fiscal Year: 2007
    ..These studies may clarify the biological role of APP family members and have important practical applications in the development of new compounds for the cure and or prevention of Alzheimer's disease. ..
  16. AIDS MALIGNANCY CONSORTIUM
    Joseph Sparano; Fiscal Year: 2005
    ..abstract_text> ..
  17. Signaling Function by APP Processing and Release of AID
    LUCIANO D ADAMIO; Fiscal Year: 2006
    ..Lastly, regulation of APP endocytosis and processing by Numb/Nbl proteins might provide potential new targets for compounds aimed to reduce Abeta production. ..
  18. Novel Animal Models of Familial British, Danish and Alzheimer's Dementia
    LUCIANO D ADAMIO; Fiscal Year: 2007
    ....