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Genomes and Genes
| GPLD1SummaryGene Symbol: GPLD1 Description: glycosylphosphatidylinositol specific phospholipase D1 Alias: GPIPLD, GPIPLDM, PIGPLD, PIGPLD1, GPI-PLD, GPI-specific phospholipase D, PI-G PLD, glycoprotein phospholipase D, phosphatidylinositol-glycan-specific phospholipase D, phospholipase D, phosphatidylinositol-glycan-specific Species: human Top Publications
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Publications
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasmaJohn C Chambers
Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
Nat Genet 43:1131-8. 2011..PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione ..- Identification of caspase 3 motifs and critical aspartate residues in human phospholipase D1b and phospholipase D2aMichelle H Wright
Department of Biological Sciences, University of Warwick, Coventry West Midlands CV4 7AL, UK
Biochem Biophys Res Commun 369:478-84. 2008.... - Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-RasMing Shi
Department of Biological Sciences, Hunter College of the City University of New York, 695 Park Avenue, New York, NY 10021, USA
Cancer Lett 258:268-75. 2007.... - Statin therapy reduces serum levels of glycosylphosphatidylinositol-specific phospholipase DMark A Deeg
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Transl Res 150:153-7. 2007..Serum glycosylphosphatidylinositol-specific phospholipase D levels are regulated by statins and may represent an additional biochemical mechanism for affecting serum triglyceride levels... - Role of glycosylphosphatidylinositol-specific phospholipase D in the homing of umbilical cord blood, mobilized peripheral blood and bone marrow-derived hematopoietic stem/progenitor cellsKui Song
Department of Hematology, Xiang Ya Hospital, Central South University, Changsha 410008, PR China
Leuk Res 31:1701-7. 2007..Our results suggested that GPI-PLD probably had no contribution to HS/PC homing, which may due to its low or no expression in UCB, BM and MPB CD34(+) cells... - Role of angiotensin II type 1A receptor phosphorylation, phospholipase D, and extracellular calcium in isoform-specific protein kinase C membrane translocation responsesAleksandra Policha
Cell Biology Research Group, Robarts Research Institute, Department of Physiology and Pharmacology, The University of Western Ontario, 100 Perth Drive, London, Ontario N6A 5K8, Canada
J Biol Chem 281:26340-9. 2006..Taken together, we show that the patterning of AT(1A)R second messenger response patterns is regulated by heterologous desensitization and PKC isoform substrate specificity... - Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchorGeorge M Verghese
Department of Medicine, University of Virginia, Charlottesville, Virginia 22908 0546, USA
Am J Physiol Cell Physiol 291:C1258-70. 2006..we show that prostasin secretion depends on GPI anchor cleavage by endogenous GPI-specific phospholipase D1 (Gpld1)... - [GPI-PLD gene exon14 polymorphisms of leucocyte in peripheral blood from healthy persons and leukemia patients]Zhi Ying Yang
Department of Biochemistry, Central South University, Changsha 410078, China
Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:28-31. 2006..To analyze the polymorphisms of glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) gene exon 14, GPI-PLD activity of leucocyte in the peripheral blood,and the relationship in leukemia patients of Han nationality in Hunan... - Cleavage with phospholipase of the lipid anchor in the cell adhesion molecule, csA, from Dictyostelium discoideumMotonobu Yoshida
Department of Agriculture, Kinki University, Nakamachi, Nara 631 8505, Japan
Comp Biochem Physiol B Biochem Mol Biol 143:138-44. 2006..In the presence of 1,10-phenanthroline, a GPI-PLD inhibitor, development of Dictyostelium was markedly inhibited, suggesting that GPI-PLD is functional in developmental regulation through cell adhesion... - Glycosylphosphatidylinositol-specific phospholipase D influences triglyceride-rich lipoprotein metabolismNandita S Raikwar
Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
Am J Physiol Endocrinol Metab 290:E463-70. 2006..These studies demonstrate that GPI-PLD affects serum TG levels by altering catabolism of TG-rich lipoproteins... - GPI-specific phospholipase D (GPI-PLD) is expressed during mouse development and is localized to the extracellular matrix of the developing mouse skeletonPatrick Gregory
Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
Bone 37:139-47. 2005..In addition, the mouse chondrocyte cell line ATDC5 expressed GPI-PLD after experimental induction of differentiation. These results implicate GPI-PLD in the process of bone formation during mouse embryogenesis... - Mutating His29, His125, His133 or His158 abolishes glycosylphosphatidylinositol-specific phospholipase D catalytic activityNandita S Raikwar
Department of Medicine, Indiana University School of Medicine and the Department of Veterans Affairs, Richard L Roudebush VAMC, Indianapolis, IN 46202, USA
Biochem J 391:285-9. 2005..Hence, His29, His125, His133 and His158 are required for GPI-PLD catalytic activity... - Effect of glycosylphosphatidylinositol specific phospholipase D gene expression levels on complement mediated killing of leukemic cells in patients with chronic myeloid leukemiaTang Jian-Hua
Department of Biochemistry, Institute of Biological Science and Technology, Central South University, Xiangya Road 88, Mail box 54number, Changsha, Hunan 410078, PR China
Clin Chim Acta 359:115-24. 2005.... - [Effect of overexpression of glycosylphosphatidylinositol-specific phospholipase D on biological character of hepatocellular carcinoma cell line HepG2]Wang jiao He
Department of Biochemistry, School of Biological Science and Technology, Central South University, Changsha, China
Zhong Nan Da Xue Xue Bao Yi Xue Ban 33:103-9. 2008..To investigate the effect of overexpression of glycosylphosphatidyl-inositol-specific phospholipase D (GPI-PLD) on the biological character of hepatocellular carcinoma cell line HepG2... - Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese womenDona L Gray
Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
Metabolism 57:473-8. 2008..Plasma GPI-PLD may serve as a clinical tool to determine the effect of a low-fat diet on insulin sensitivity... - Effects of membrane cholesterol depletion and GPI-anchored protein reduction on osteoblastic mechanotransductionYanghui Xing
Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Cell Physiol 226:2350-9. 2011..Our findings suggest that cholesterol and GPI-anchored proteins, two membrane structural components related to lipid rafts, may play an important role in osteoblastic cell mechanotransduction... - Human and mouse mast cells express and secrete the GPI-anchored isoform of CD160Nicolas Ortonne
AP HP, Groupe Hospitalier Henri Mondor Albert Chenevier, Department of Pathology, and Université Paris 12, Faculte de Medecine, Creteil, France
J Invest Dermatol 131:916-24. 2011..We also demonstrated an inhibition of T-cell cytotoxicity by HMC-1 supernatant that was partially reversed by anti-CD160 mAb. In conclusion, sCD160, produced by MCs, may have a role in T-cell-MC interactions in vivo... - Pulmonary fibrosis inducer, bleomycin, causes redox-sensitive activation of phospholipase D and cytotoxicity through formation of bioactive lipid signal mediator, phosphatidic acid, in lung microvascular endothelial cellsRishi B Patel
Lipid Signaling, Lipidomics, and Vasculotoxicity Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Dorothy M Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, 43210, USA
Int J Toxicol 30:69-90. 2011.... - An essential role for phospholipase D in the recruitment of vesicle amine transport protein-1 to membranes in human neutrophilsDelphine Faugaret
Centre de Recherche en Rhumatologie et Immunologie, Centre de recherche du CHUQ CHUL et Faculté de Médecine de l Université Laval, 2705 Boulevard Laurier, Local T1 49, Quebec, QC, G1V 4G2, Canada
Biochem Pharmacol 81:144-56. 2011..Characterization of these putative PA-binding proteins constitutes another step forward for a better understanding of the role of PLD-derived PA in neutrophil physiology... - PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic diseaseElizabeth K Speliotes
Department of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
Hepatology 52:904-12. 2010..CONCLUSION: Genetic variation at PNPLA3 confers a markedly increased risk of increasingly severe histological features of NAFLD, without a strong effect on metabolic syndrome component traits... - Glycosylphosphatidylinositol-specific phospholipase D improves glucose toleranceNandita S Raikwar
Department of Medicine and of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Metabolism 59:1413-20. 2010..Overexpressing GPI-PLD in an insulinoma cell line enhanced glucose-stimulated insulin secretion, suggesting that enhanced insulin secretion in vivo may have contributed to the improved glucose tolerance... - [Expression and activity of glycosylphosphatidylinositol-specific phospholipase d mRNA in bone marrow mononuclear cells isolated from patient with acute myeloid leukemia and their significance]Guang Fen Xiao
Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:15-8. 2010..It is worthy of further exploring whether GPI-PLD plays a certain role in process of leukemia pathogenesis... - Wnt signaling is regulated by endoplasmic reticulum retentionJ Susie Zoltewicz
Ernest Gallo Clinic and Research Center, Emeryville, CA, USA
PLoS ONE 4:e6191. 2009..Our work highlights a critical role for ER retention in regulating Wnt signaling in the mouse embryo, and gives insight into the notoriously inefficient secretion of Wnts... - Important roles of glycosylphosphatidylinositol (GPI)-specific phospholipase D and some GPI-anchored proteins in the pathogenesis of hepatocellular carcinomaJian hua Tang
Department of Biochemistry, School of Biological Sciences and Technology, Central South University, 172 Tong Zi Po Road, Changsha, Hunan 410013, PR China
Clin Biochem 42:400-7. 2009..To investigate the roles of glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) in the pathogenesis of hepatocellular carcinoma (HCC)... - Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymesXin Yuan
Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
Am J Hum Genet 83:520-8. 2008..GGT) levels (HNF1A on chromosome 12), and three loci for alkaline phosphatase (ALP) levels (ALPL on chromosome 1, GPLD1 on chromosome 6, and JMJD1C-REEP3 on chromosome 10)... - Activated human neutrophils rapidly release the chemotactically active D2D3 form of the urokinase-type plasminogen activator receptor (uPAR/CD87)Boris K Pliyev
Department of Biological and Medical Chemistry, Faculty of Fundamental Medicine, Moscow State University, Moscow, Russia
Mol Cell Biochem 321:111-22. 2009.... - Transcriptome studies of bovine endometrium reveal molecular profiles characteristic for specific stages of estrous cycle and early pregnancyS Bauersachs
Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Munich, Germany
Exp Clin Endocrinol Diabetes 116:371-84. 2008..C4, SERPING1, UTMP, CD81, IFITM1, BST2), as well as genes affecting cell adhesion ( AGRN, CD81, LGALS3BP, LGALS9, GPLD1, MFGE8, and TGM2) and remodeling of the endometrium ( CLDN4, MEP1B, LGMN, MMP19, TIMP2, TGM2, MET, and EPSTI1)... - Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cellsKaren I Mead
Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom
J Immunol 174:4803-11. 2005..Taken together, these data suggest that CTLA-4 may be stored in a specialized compartment in regulatory T cells that can be triggered rapidly for deployment to the PM in a phospholipase D- and ADP ribosylation factor-1-dependent manner... - Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipasesDavid R Jones
Department of Cell Signalling, Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Arturo Duperier 4, 28029 Madrid, Spain
FEBS Lett 579:59-65. 2005..These phosphorylation events may constitute the basis of a previously undescribed signal transduction mechanism... - Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) geneJ N Schofield
Molecular Medicine Unit, Department of Molecular Pathology, University College London, Windeyer Institute, 46 Cleveland Street, W1P 6DB, London, UK
Biochim Biophys Acta 1494:189-94. 2000..8 kb mRNA, which was detected only in the liver. Southern blot analysis shows that the human genome contains only one GPLD gene and we could only detect one of the two previously reported cDNAs... - Characterization of phospholipase D activation by GM2 activator in a cell-free systemH Jinnai
Department of Biochemistry, Kobe University School of Medicine
Kobe J Med Sci 45:181-90. 1999..These results facilitate the understanding how the metabolism of both phospholipids and gangliosides is regulated by the same protein... - Inhibition of the plasma glycosylphosphatidylinositol-specific phospholipase D by synthetic analogs of lipid A and phosphatidic acidM G Low
Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, New York, New York 10032, USA
Arch Biochem Biophys 371:332-9. 1999..We propose that this diverse group of inhibitors all bind to a common site on GPI-PLD, the central hydrophobic cavity predicted by the beta-propeller model for integrin alpha subunits and GPI-PLD... - Midportion antibodies stimulate glycosylphosphatidylinositol-specific phospholipase D activityM A Deeg
Department of Medicine, Indiana University School of Medicine and The Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202 2284, USA
Arch Biochem Biophys 370:278-84. 1999..Consistent with this is the observation that both manipulations decreased the affinity of GPI-PLD for mixed micelle substrates. These results indicate that the midportion region of GPI-PLD is important in regulating enzymatic activity... - Glycosylphosphatidylinositol-specific phospholipase D is expressed by macrophages in human atherosclerosis and colocalizes with oxidation epitopesK D O'Brien
Division of Cardiology, Department of Medicine, University of Washington, Seattle, USA
Circulation 99:2876-82. 1999..Because of its potential regulatory role in inflammatory reactions, we hypothesized that GPI-PLD might be expressed in atherosclerosis... - Glycosylphosphatidylinositol-specific phospholipase D in blood serum: is the liver the only source of the enzyme?H Rhode
Institute of Biochemistry, Medical Faculty, Friedrich Schiller University, Jena, Germany
Clin Chim Acta 281:127-45. 1999..To find possible other sources of plasma GPI-PLD besides the liver, the GPI-degrading activity was measured in different organs of the rat. Product formation was analysed using [125I]TID-labeled GPI-AP... - Mouse glycosylphosphatidylinositol-specific phospholipase D (Gpld1) characterizationR C LeBoeuf
Departments of Medicine and Nutritional Sciences, University of Washington, Box 353410, Seattle, Washington 98195 3410, USA
Mamm Genome 9:710-4. 1998..There is a single structural gene (Gpld1) mapping to mouse Chromosome (Chr) 13, and among nine tissues, liver showed the greatest abundance of GPI-PLD mRNA... - Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cellsM A Deeg
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
Endocrinology 138:819-26. 1997..These results demonstrate that beta TC3 cells secrete GPI-PLD in response to insulin secretagogues and suggest that GPI-PLD may be secreted via the regulated pathway in these cells... - Cell surface expression of a functional rubella virus E1 glycoprotein by addition of a GPI anchorE Bernasconi
Institut de Biologie Animale, Universite de Lausanne, Switzerland
J Cell Sci 109:1195-201. 1996..This study thus demonstrates that the GPI anchor has a dominant effect over the E1 pre-Golgi retention signal and that E1 is sufficient for hemadsorption... - Release of GPI-anchored membrane proteins by a cell-associated GPI-specific phospholipase DC N Metz
Department of Pathology, New York University Medical Center, NY 10016
EMBO J 13:1741-51. 1994..These studies are the first demonstration of the physiologically relevant release of GPI-anchored proteins from cells by a GPI-PLD... - Purification and characterization of glycosyl-phosphatidylinositol-specific phospholipase DK S Huang
Department of Protein Biochemistry, Hoffmann La Roche Inc, Nutley, New Jersey 07110
J Biol Chem 265:17738-45. 1990..Based upon these criteria, it appears that the purified enzyme is distinct from other phospholipases with specificity for inositol phospholipids... - Primary structure and functional activity of a phosphatidylinositol-glycan-specific phospholipase DB J Scallon
Department of Molecular Cellular Biology and Biochemistry, Hoffmann La Roche, Inc, Nutley, NJ 07110
Science 252:446-8. 1991..Cotransfection of PI-G PLD with a PI-G-anchored protein resulted in the secretion of the PI-G-anchored protein. The results suggest that the expression of PI-G PLD may influence the expression and location of PI-G-anchored proteins... - GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complexM A Deeg
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Lipid Res 42:442-51. 2001..Deeg, M. A., E. L. Bierman, and M. C. Cheung. GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex. J. Lipid Res. 2001. 42: 442--451... - Increased expression of GPI-specific phospholipase D in mouse models of type 1 diabetesM A Deeg
Department of Medicine, Indiana University School of Medicine and The Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
Am J Physiol Endocrinol Metab 281:E147-54. 2001..Our data demonstrate that serum GPI-PLD levels are altered in the diabetic state and are consistent with liver as a contributor to circulating GPI-PLD... - D3 dopamine receptor activates phospholipase D through a pertussis toxin-insensitive pathwayP Benjamin Everett
Department of Molecular Sciences, University of Tennessee Health Science Center, Suite G01, 858 Madison Avenue, Memphis, TN 38163, USA
Neurosci Lett 371:34-9. 2004..PLD activation is a novel finding for the D(3) receptor, and is the first example of an effector system where D(3) signals without G(i)/G(o) protein intermediates... - Characterization of primate trypanosome lytic factorsElena B Lugli
Department of Medical and Molecular Parasitology, New York University School of Medicine, 341, East 25th Street, New York, NY 10010, USA
Mol Biochem Parasitol 138:9-20. 2004..These findings suggest that apoL-I is not essential in all primate TLFs, and apoL-I alone is not sufficient for optimal trypanosome lytic activity in human TLF... - A distant evolutionary relationship between GPI-specific phospholipase D and bacterial phosphatidylcholine-preferring phospholipase CDaniel J Rigden
School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
FEBS Lett 569:229-34. 2004..The databases contain hitherto unnoticed close homologues of GPI-PLD from yeast and Dictyostelium discoideum... - Insulin resistance is associated with increased serum levels of glycosylphosphatidylinositol-specific phospholipase DTrisha A Kurtz
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Metabolism 53:138-9. 2004..These results suggest that increased serum GPI-PLD is associated with the insulin resistance... - Anti-mouse GPI-PLD antisera highlight structural differences between murine and bovine GPI-PLDsPatrick Gregory
Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, CH 3012 Bern, Switzerland
Biol Chem 384:1575-82. 2003..We discuss the implications of these results and stress the importance of antibody selection while investigating GPI-PLD in the mouse... - [Preliminary study of the gene structure of human glycosylphosphatidylinositol specific phospholipase D]J H Tang
Department of Biochemistry, Xiangya Medical College, Central South University, Changsha 410078, China
Hunan Yi Ke Da Xue Xue Bao 26:95-7. 2001..1-22.3 and contained 25 exons, TATA box, CAAT box, enhancer and the sequence binding homo domain of Pit-1/GHF-1... - Different distributions of human bone alkaline phosphatase isoforms in serum and bone tissue extractsPer Magnusson
Department of Biomedicine and Surgery, Bone and Mineral Metabolic Unit, Division of Clinical Chemistry, Linkoping University Hospital, SE 581 85 Linkoping, Sweden
Clin Chim Acta 325:59-70. 2002..Previous studies have shown that the relative abundance of these BALP isoforms in serum may be clinically useful for the diagnosis and management of metabolic bone disease... - GPI-specific phospholipase D mRNA expression in tumor cells of different malignancyH Xiaotong
Department of Cancer Research, Fachklinik Hornheide, University of Munster, Germany
Clin Exp Metastasis 19:291-9. 2002..The competitive RT-PCR described here represents the first quantitative assay specific for cellular GPI-PLD isoforms, and our in vitro analyses suggest that GPI-PLD expression might be associated with tumor malignancy... - Phosphorylation decreases trypsin activation and apolipoprotein al binding to glycosylphosphatidylinositol-specific phospholipase DMark A Deeg
Department of Medicine, Indiana University School of Medicine and the Department of Veterans Affairs, Indianapolis 46202, USA
Biochem Cell Biol 80:253-60. 2002..Phosphorylation also inhibits binding of GPI-PLD to apolipoprotein AI. These data are the first demonstrating that phosphorylation may regulate GPI-PLD interaction with other proteins... - Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatoninJ Jaworek
Department of Physiology, University School of Medicine, Jagiellonian University, Krakow, Poland
J Physiol Pharmacol 53:51-74. 2002.... - Screening and modulation of extracellular signals by mucous barrier. Serum glycosylphosphatidylinositol phospholipase D (GPI-PLD) releases protective mucous barrier from oral mucosaA Slomiany
University of Medicine and Dentistry of New Jersey, Research Center, Newark 07103 2400, USA
J Physiol Pharmacol 53:21-38. 2002..The aim ofthe studies described was to determine the nature of the damage or modification of oral mucous barrier by the short-term exposure to ethanol... - [Methodological study on the assay of glycosylphosphatidylinositol-specific phospholipase D activity in serum]J Tang
Department of Biochemistry, Hunan Medical University, Changsha 410078
Hunan Yi Ke Da Xue Xue Bao 24:119-22. 1999..The activities of GPI-PLD measured by this method in 100 normal subjects ranged from 30% to 50% (in terms of the percentage of converting GPI anchored PLAP substrate to the anchor-free product)... - Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteinsM C Hoener
Institut fur Biochemie und Molekularbiologie, Universitat Bern, Switzerland
Eur J Biochem 206:747-57. 1992....
Research Grants
- Analysis of Fatty Liver in the Framingham Heart Study CohortELIZABETH SPELIOTES; Fiscal Year: 2007....
- Membrane Tryptic Serine Proteases in Lung EpitheliumGeorge Verghese; Fiscal Year: 2005..The research and career development plan will prepare the candidate to become an independent investigator in lung biology. ..
- Plaque Inflammation and Dysfunctional HDL in AIM-HIGHKEVIN DOUGLAS O apos BRIEN; Fiscal Year: 2010..We will test the hypothesis that niacin helps to block the inflammation that breaks down atherosclerotic plaques by improving the ability of "good" cholesterol, HDL, to repair inflammatory damage to the plaque. ..