galactosyltransferase

Summary

Gene Symbol: galactosyltransferase
Description: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Alias: B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1, beta-1,4-GalTase 1, beta-1,4-galactosyltransferase 1, glycoprotein-4-beta-galactosyltransferase 2, lactose synthase
Species: human

Top Publications

  1. ncbi An antibody produced in tobacco expressing a hybrid beta-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes
    Hans Bakker
    Business Unit Bioscience, Plant Research International, Wageningen University and Research Center, Droevendaalsesteeg 1, 6708 PB, Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 103:7577-82. 2006
  2. ncbi Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis
    Jillian R Brown
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 284:4952-9. 2009
  3. ncbi Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins
    N Yamaguchi
    La Jolla Cancer Research Foundation, California 92037, USA
    J Biol Chem 270:12170-6. 1995
  4. ncbi Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase
    L C Lopez
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    J Biol Chem 266:15984-91. 1991
  5. ncbi Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated
    Beat E Schaub
    Institute of Physiology, University of Zurich, CH 8057 Zurich, Switzerland
    Mol Biol Cell 17:5153-62. 2006
  6. ncbi Cell surface beta 1, 4-galactosyltransferase 1 promotes apoptosis by inhibiting epidermal growth factor receptor pathway
    Zejuan Li
    Gene Research Center, Shanghai Medical College of Fudan University, Shanghai, China, 200032
    Mol Cell Biochem 291:69-76. 2006
  7. ncbi Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId
    Bengt Hansske
    Abteilung Biochemie II, Georg August Universitat Gottingen, Heinrich Düker Weg 12, D 37073 Gottingen, Germany
    J Clin Invest 109:725-33. 2002
  8. ncbi National tuberculosis programme review: experience over the period 1990-95
    A Pio
    National Programme Support, Global Tuberculosis Programme, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 75:569-81. 1997
  9. ncbi Transcriptional regulation of P450scc gene expression in neural and steroidogenic cells: implications for regulation of neurosteroidogenesis
    P Zhang
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco 94143, USA
    Mol Endocrinol 9:1571-82. 1995
  10. ncbi Transcription factors Oct-1 and C/EBPbeta (CCAAT/enhancer-binding protein-beta) are involved in the glutamate/nitric oxide/cyclic-guanosine 5'-monophosphate-mediated repression of mediated repression of gonadotropin-releasing hormone gene expression
    D D Belsham
    Department of Reproductive Medicine, The Center for Molecular Genetics, University of Califonia, La Jolla 92093, USA
    Mol Endocrinol 14:212-28. 2000

Research Grants

  1. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    Pamela L Mellon; Fiscal Year: 2010
  2. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    PAMELA MELLON; Fiscal Year: 2007
  3. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    PAMELA MELLON; Fiscal Year: 1993
  4. Circadian Regulation of Gonadotropin-Releasing Hormone
    Patrick E Chappell; Fiscal Year: 2010
  5. AUTOREGULATION OF GLOMERULAR FILTRATION RATE
    Roland Blantz; Fiscal Year: 2000
  6. B-Synuclein as a Treatment for Lewy Body Disease
    Eliezer Masliah; Fiscal Year: 2005
  7. AUTOREGULATION OF GLOMERULAR FILTRATION RATE
    Roland Blantz; Fiscal Year: 2004
  8. MOLECULAR MECHANISM OF PHOTORECEPTOR G PROTEIN SIGNALING
    Nikolai O Artemyev; Fiscal Year: 2010
  9. AUTOREGULATION OF GLOMERULAR FILTRATION RATE
    Roland Blantz; Fiscal Year: 2009
  10. AUTOREGULATION OF GLOMERULAR FILTRATION RATE
    Roland Blantz; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications149 found, 100 shown here

  1. ncbi An antibody produced in tobacco expressing a hybrid beta-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes
    Hans Bakker
    Business Unit Bioscience, Plant Research International, Wageningen University and Research Center, Droevendaalsesteeg 1, 6708 PB, Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 103:7577-82. 2006
    ..N-terminal domain of Arabidopsis thaliana xylosyltransferase and the catalytic domain of human beta-1,4-galactosyltransferase I (GalT), in tobacco causes a sharp reduction of N-glycans with potentially immunogenic core-bound xylose (..
  2. ncbi Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis
    Jillian R Brown
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 284:4952-9. 2009
    ..we show that GlcNAcbeta1-3Galbeta-O-naphthalenemethanol binds to the acceptor site of human beta1-4-galactosyltransferase much like the acceptor trisaccharide, GlcNAcbeta1-2Manbeta1-6Man, which is present on N-linked glycans...
  3. ncbi Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins
    N Yamaguchi
    La Jolla Cancer Research Foundation, California 92037, USA
    J Biol Chem 270:12170-6. 1995
    ..We show here that beta-1,4-galactosyltransferase (GT) forms homodimers and large oligomers in vivo, and the formation of the homodimers is dependent on ..
  4. ncbi Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase
    L C Lopez
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    J Biol Chem 266:15984-91. 1991
    beta 1,4-Galactosyltransferase (GalTase) is present on the plasma membrane of many cell types in addition to its traditional location within the Golgi compartment...
  5. ncbi Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated
    Beat E Schaub
    Institute of Physiology, University of Zurich, CH 8057 Zurich, Switzerland
    Mol Biol Cell 17:5153-62. 2006
    ..Here we investigate beta1,4-galactosyltransferase 1 (galT) and alpha2,6-sialyltransferase 1 (siaT), two trans-Golgi glycosyltransferases, with respect to ..
  6. ncbi Cell surface beta 1, 4-galactosyltransferase 1 promotes apoptosis by inhibiting epidermal growth factor receptor pathway
    Zejuan Li
    Gene Research Center, Shanghai Medical College of Fudan University, Shanghai, China, 200032
    Mol Cell Biochem 291:69-76. 2006
    ..These results demonstrated that cell surface beta1,4GT1 may negatively regulate cell survival possibly through inhibiting and modulating EGFR signaling pathway...
  7. ncbi Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId
    Bengt Hansske
    Abteilung Biochemie II, Georg August Universitat Gottingen, Heinrich Düker Weg 12, D 37073 Gottingen, Germany
    J Clin Invest 109:725-33. 2002
    Deficiency of the Golgi enzyme UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase I (beta4GalT I) (E.C.2.4.1...
  8. ncbi National tuberculosis programme review: experience over the period 1990-95
    A Pio
    National Programme Support, Global Tuberculosis Programme, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 75:569-81. 1997
    Since 1990 the WHO Global Tuberculosis Programme (GTB) has promoted the revision of national tuberculosis programmes to strengthen the focus on directly observed treatment, short-course (DOTS) and close monitoring of treatment outcomes...
  9. ncbi Transcriptional regulation of P450scc gene expression in neural and steroidogenic cells: implications for regulation of neurosteroidogenesis
    P Zhang
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco 94143, USA
    Mol Endocrinol 9:1571-82. 1995
    ..gene was assessed in mouse adrenocortical Y-1, mouse Leydig MA-10, rat C6 glioma, rat GC somatotrope, and mouse GT1-7 neurosecretory cell lines...
  10. ncbi Transcription factors Oct-1 and C/EBPbeta (CCAAT/enhancer-binding protein-beta) are involved in the glutamate/nitric oxide/cyclic-guanosine 5'-monophosphate-mediated repression of mediated repression of gonadotropin-releasing hormone gene expression
    D D Belsham
    Department of Reproductive Medicine, The Center for Molecular Genetics, University of Califonia, La Jolla 92093, USA
    Mol Endocrinol 14:212-28. 2000
    ..transduction pathway through cGMP-dependent protein kinase in the hypothalamic GnRH-secreting neuronal cell line GT1-7. This repression localized within a previously characterized 300-bp neuron-specific enhancer...
  11. ncbi Characterization of gonadotropin-releasing hormone gene transcripts in a mouse hypothalamic neuronal GT1 cell line
    T T Yeo
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res Mol Brain Res 42:255-62. 1996
    ..RNA transcripts derived from the gonadotropin releasing hormone (GnRH) gene in a mouse hypothalamic neuronal GT1 cell line...
  12. ncbi Structure-function analysis of the UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. Essential residues lie in a predicted active site cleft resembling a lactose repressor fold
    F K Hagen
    Center for Oral Biology, Rochester Institute of Biomedical Sciences, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 274:6797-803. 1999
    ..The 112-amino acid glycosyltransferase 1 (GT1) motif represents the first half of the catalytic unit and contains a short aspartate-any residue-histidine (DXH) ..
  13. ncbi Differences between two real-time PCR-based hepatitis C virus (HCV) assays (RealTime HCV and Cobas AmpliPrep/Cobas TaqMan) and one signal amplification assay (Versant HCV RNA 3.0) for RNA detection and quantification
    Johannes Vermehren
    Zentrum der Inneren Medizin, Medizinische Klinik 1, Klinikum der JW Goethe Universität, Frankfurt am Main, Germany
    J Clin Microbiol 46:3880-91. 2008
    ..Commercially available HCV RNA assays are calibrated to the HCV genotype 1 (gt1)-based WHO standard. Significant differences between assays have been reported...
  14. ncbi A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3
    R Almeida
    School of Dentistry, University of Copenhagen, Norre Alle 20, DK 2200 Copenhagen N, Denmark
    J Biol Chem 272:31979-91. 1997
    ..tags (ESTs) using the coding sequence of the human UDP-galactose:beta-N-acetylglucosamine beta1, 4-galactosyltransferase, designated beta4Gal-T1, revealed a large number of ESTs with identical as well as similar sequences...
  15. ncbi DNA barcoding identifies Eimeria species and contributes to the phylogenetics of coccidian parasites (Eimeriorina, Apicomplexa, Alveolata)
    Joseph D Ogedengbe
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Road, Guelph, Ontario, Canada N1G 2W1
    Int J Parasitol 41:843-50. 2011
    ..chickens as well as three additional sequences from cloned laboratory strains of Toxoplasma gondii (ME49 and GT1) and Neospora caninum (NC1) that were used as outgroup taxa for phylogenetic analyses...
  16. ncbi A novel mechanism for endocrine-disrupting effects of polychlorinated biphenyls: direct effects on gonadotropin-releasing hormone neurones
    A C Gore
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Brookdale Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neuroendocrinol 14:814-23. 2002
    ..The effects of two PCB mixtures, Aroclor 1221 and Aroclor 1254, were tested on the hypothalamic GT1-7 cells, which synthesize and secrete the key hypothalamic hormone, gonadotropin-releasing hormone (GnRH)...
  17. ncbi Specific gene targeting in Spiroplasma citri: improved vectors and production of unmarked mutations using site-specific recombination
    Sybille Duret
    UMR 1090 Génomique Développement et Pouvoir Pathogène, INRA, Universite de Bordeaux 2, Centre INRA de Bordeaux, Villenave D Ornon, France
    Microbiology 151:2793-803. 2005
    ..In contrast to the wild-type strain GII-3, the crr-disrupted mutant GII3-gt1 used neither glucose nor trehalose, indicating that in S...
  18. ncbi Transforming growth factor beta1 may directly influence gonadotropin-releasing hormone gene expression in the rat hypothalamus
    Sebastien Bouret
    Institut National de la Santé et de la Recherche Médicale Unité 422, Lille, France
    Endocrinology 145:1794-801. 2004
    In vitro studies using immortalized GT1 cells suggest that hypothalamic astrocytes employ TGFbeta(1) to directly regulate the secretion of GnRH, the neurohormone that controls sexual maturation and adult reproductive function...
  19. ncbi Neuropeptide-induced transactivation of a neuronal epidermal growth factor receptor is mediated by metalloprotease-dependent formation of heparin-binding epidermal growth factor
    Bukhtiar H Shah
    Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Biol Chem 279:414-20. 2004
    ..In immortalized hypothalamic neurons (GT1-7 cells), agonist binding to the gonadotropin-releasing hormone receptor (GnRH-R) causes phosphorylation of MAPKs ..
  20. ncbi Effects of glucose and insulin on glucokinase activity in rat hypothalamus
    Carmen Sanz
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, Madrid, Spain
    J Endocrinol 193:259-67. 2007
    ..and on the activity of this enzyme in the hypothalamus, we used two kinds of biological models: hypothalamic GT1-7 cells and rat hypothalamic slices...
  21. ncbi Potentiation, activation and blockade of GABAA receptors of clonal murine hypothalamic GT1-7 neurones by propofol
    S Adodra
    Department of Anesthesiology, UCLA Medical Center 90024, USA
    Br J Pharmacol 115:953-60. 1995
    ..and the intravenous general anaesthetic propofol (2,6-diisopropylphenol) on GABAA receptors of self-replicating GT1-7 hypothalamic neurones were investigated by the patch clamp technique. 2...
  22. ncbi Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis
    T Schwientek
    School of Dentistry, University of Copenhagen, Norre Alle 20, 2200 Copenhagen N, Denmark
    J Biol Chem 273:29331-40. 1998
    A novel putative member of the human UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, designated beta4Gal-T4, was identified by BLAST analysis of expressed sequence tags...
  23. ncbi Substrate specificity and inhibitor studies of a membrane-bound ganglioside sialidase isolated from human brain tissue
    Christian Oehler
    Institute of Pathochemistry and Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220 221, D 69120 Heidelberg, Germany
    Biol Chem 383:1735-42. 2002
    ..The sialidase removed terminal sialic acids from gangliosides GM3, GM4, GD3, GD2, GD1 a, GD1 b, GT1 b and GQ1 b, but was inactive toward gangliosides with sialic acid in a branching position (as in GM1 and GM2)...
  24. ncbi Promoter usage and estrogen regulation of prolactin receptor gene in the brain of the female rat
    Xiujun Pi
    Department of Molecular and Integrative Physiology, Kansas University Medical Center, Kansas City, Kansas 66160 7401, USA
    Neuroendocrinology 77:187-97. 2003
    ..The expression of PRL-R mRNA was up-regulated by estrogen treatment in the rat brain tissue and in the GT1-7 cell culture...
  25. ncbi Characterization of chloride efflux from GT1-7 neurons: lack of effect of ethanol on GABAA response
    M A Javors
    Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284, USA
    Brain Res 780:183-9. 1998
    The purpose of this study of GT1-7 neurons was to partially characterize basal Cl- transport and GABAA mediated Cl- efflux and to test the effect of ethanol on a GABAA receptor that lacks a gamma subunit...
  26. ncbi A glutamine transport gene, glnQ, is required for fibronectin adherence and virulence of group B streptococci
    Glen S Tamura
    Children s Hospital and Regional Medical Center and the University of Washington, Seattle, Washington 98105, USA
    Infect Immun 70:2877-85. 2002
    ..GBS adhere to fibronectin when it is attached to a solid phase. We isolated a Tn917 transposon mutant, COH1-GT1, which shows decreased adherence to fibronectin...
  27. ncbi Assignment of 12 loci to rat chromosome 5: evidence that this chromosome is homologous to mouse chromosome 4 and to human chromosomes 9 and 1 (1p arm)
    C Szpirer
    Universite Libre de Bruxelles, Departement de Biologie Moleculaire, Rhode St Genese, Belgium
    Genomics 6:679-84. 1990
    ..chromosome 5: aldolase B (ALDOB), atrial natriuretic factor (ANF = pronatriodilatin, PND), D4RP1, DSI1, galactosyltransferase (GGTB2), glucose transporter (GLUT1), interferon alpha 1 and related interferon alpha (INFA), interferon ..
  28. ncbi Concentration-dependent effects of muscimol to enhance pulsatile GnRH release from GT1-7 neurons in vitro
    T S King
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78284 7762, USA
    Brain Res 824:56-62. 1999
    Immortalized GT1-7 neurons were used to characterize the effect of muscimol, a GABAA receptor agonist, to enhance pulsatile gonadotropin-releasing hormone (GnRH) release...
  29. ncbi Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1
    Dong yu Wang
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario M5S 3E5, Canada
    Mol Endocrinol 18:402-11. 2004
    ..These results provide evidence that some estrogenic compounds differentially enhance the transcription of estrogen-regulated genes and suggest a role for EEIG1 in estrogen action...
  30. ncbi Scavenging of hydrogen peroxide and inhibition of ultraviolet light-induced oxidative DNA damage by aqueous extracts from green and black teas
    H Wei
    Department of Dermatology, Mount Sinai NYU Medical Center, New York, NY 10029, USA
    Free Radic Biol Med 26:1427-35. 1999
    ..been extracted by serial chloroform, ethyl acetate and n-butanol, and divided into four subfractions designated as GT1-4 for green tea and BT1-4 for black tea, respectively...
  31. ncbi Cross-talk signals in the CNS: role of neurotrophic and hormonal factors, adhesion molecules and intercellular signaling agents in luteinizing hormone-releasing hormone (LHRH)-astroglial interactive network
    B Marchetti
    Department of Pharmacology, Medical School, University of Catania, 95125 Catania, Italy
    Front Biosci 2:d88-125. 1997
    ..Different experimental paradigms such as co-culture and mixed culture models between the GT1-1 neurons and astroglial cells in primary culture, disclosed the presence of a bi-directional flow of informational ..
  32. ncbi Maternal and cord blood levels of aldrin and dieldrin in Delhi population
    Md Mustafa
    Environmental Biochemistry and Immunology Laboratory, Department of Biochemistry, University College of Medical Sciences and G T B Hospital, University of Delhi, Dilshad Garden, Delhi, 110 095, India
    Environ Monit Assess 171:633-8. 2010
    ..belonging to north Indian population undergoing normal delivery at Obstetrics and Gynecology department of UCMS and GTB hospital, Delhi...
  33. ncbi Crystal structures of the bovine beta4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose
    L N Gastinel
    Architecture et Fonction des Macromolécules Biologiques AFMB, CNRS, UPR 9039, 31 Chemin Joseph Aiguier 13402 Marseille Cedex 20, France
    EMBO J 18:3546-57. 1999
    beta1,4-galactosyltransferase T1 (beta4Gal-T1, EC 2.4.1...
  34. ncbi Pancreatic lipase activity as influenced by unconjugated bile acids and pH, measured in vitro and in vivo
    Ane Knarreborg
    Department of Animal Nutrition and Physiology, Danish Institute of Agricultural Sciences, Research Centre Foulum, 8830 Tjele, Denmark
    J Nutr Biochem 14:259-65. 2003
    ..in vitro using automatic titration, where the fatty acids liberated from the hydrolysis of glycerol tributyrate (GTB) were measured...
  35. ncbi Second messenger regulation of mouse gonadotropin-releasing hormone gene expression in immortalized mouse hypothalamic GT1-3 cells
    K L Yu
    Dr Arthur M Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029
    Mol Cell Endocrinol 102:85-92. 1994
    Using a transgenic mouse derived GnRH expressing neuronal cell line, GT1-3, we studied the effects of activation of cAMP, Ca2+ and protein kinase C pathways by forskolin, ionomycin and the phorbol ester phorbol 12-myristate 13-acetate (..
  36. ncbi Cetrorelix, a gonadotropin-releasing hormone antagonist, induces the expression of melatonin receptor 1a in the gonadotropin-releasing hormone neuronal cell line GT1-7
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, Tokyo, Japan
    Neuroendocrinology 90:251-9. 2009
    ..Using immortalized GnRH neurons (GT1-7 cells), the present study investigated the mechanism by which the expression of melatonin receptors is regulated ..
  37. ncbi Connexin 26 expression and extensive gap junctional coupling in cultures of GT1-7 cells secreting gonadotropin-releasing hormone
    L Hu
    Department of Obstetrics and Gynecology, Reproductive Endocrinology Center, San Francisco, Calif, USA
    Neuroendocrinology 70:221-7. 1999
    ..A previous study using GnRH-secreting GT1-7 cells reported that connexin 26 was the major GJ subunit present, and that about 20% of the cultured cells ..
  38. ncbi Contrasting strategies to cope with chilling stress among clones of a tropical tree, Hevea brasiliensis
    Jing Mai
    Clermont Universite, Universite Blaise Pascal, UMR PIAF, BP 10448, F 63000 Clermont Ferrand Cedex, France
    Tree Physiol 30:1391-402. 2010
    Eight Hevea brasiliensis Muell. Arg. clones (GT1, YUNYAN77-4, IRCA707, IRCA317, PB217, PB260, PR107 and RRIM600) were compared for their tolerance towards chilling stress...
  39. ncbi Precise cell patterning using cytophobic self-assembled monolayer deposited on top of semi-transparent gold
    Gaoshan Jing
    Sherman Fairchild Center, Department of Electrical and Computer Engineering, Lehigh University, Bethlehem, USA
    Biomed Microdevices 12:935-48. 2010
    ..the patterning of four different kinds of cells using this technique: immortalized mouse hypothalamic neurons (GT1-7), mouse osteoblast cells (MC3T3), mouse fibroblast cells (NIH3T3) and primary rat hippocampal neurons...
  40. ncbi Enzymatic synthesis of Gb3 and iGb3 ceramides
    Dietlind Adlercreutz
    Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK 2500 Valby, Denmark
    Carbohydr Res 345:1384-8. 2010
    ..In the current investigation we evaluated human blood group B galactosyltransferase (GTB) for its ability to catalyze the formation of iGb3 from lactosylceramide and UDP-Galp...
  41. ncbi Cytomegalovirus and rubella infection in children and pregnant mothers--a hospital based study
    Shukla Das
    Dept Of Microbiology University College of Medical Sciences and Guru Tegh Bahadur Hospital, Shahdara, Delhi 110095, India
    J Commun Dis 39:113-7. 2007
    ..study was to find the prevalence of CMV and rubella infection in the vulnerable section of our population attending GTB hospital...
  42. ncbi Roles of Src and epidermal growth factor receptor transactivation in transient and sustained ERK1/2 responses to gonadotropin-releasing hormone receptor activation
    Bukhtiar H Shah
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Biol Chem 278:19118-26. 2003
    ..is relatively sustained in alpha T3-1 pituitary gonadotropes and HEK293 cells but is transient in immortalized GT1-7 neurons...
  43. ncbi Identifying candidate genes affecting developmental time in Drosophila melanogaster: pervasive pleiotropy and gene-by-environment interaction
    Julián Mensch
    Departamento de Ecologia, Genetica y Evolucion, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
    BMC Dev Biol 8:78. 2008
    ..The present work is one of the first systematic studies of the genetic basis of developmental time, in which we also evaluate the impact of environmental variation on the expression of the trait...
  44. ncbi R-etodolac (SDX-101) and the related indole-pyran analogues SDX-308 and SDX-309 potentiate the antileukemic activity of standard cytotoxic agents in primary chronic lymphocytic leukaemia cells
    Elin Lindhagen
    Division of Clinical Pharmacology, Uppsala University, Uppsala, Sweden
    Cancer Chemother Pharmacol 60:545-53. 2007
    ..The current study was performed to investigate and quantify the cytotoxic potentiating effects resulting from a combination of either SDX-101, SDX-308 or SDX-309 with standard cytotoxic agents used in the CLL treatment today...
  45. ncbi Cloning, expression, and characterization of a thermostable PAP2L2, a new member of the type-2 phosphatidic acid phosphatase family from Geobacillus toebii T-85
    Yong Zhang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, PR China
    Biosci Biotechnol Biochem 72:3134-41. 2008
    ..Here we describe the cloning of a novel gene from Geobacillus toebii T-85, encoding a PAP2-like protein, Gtb PAP2L2, which contains 212 amino acids and shows a limited homology to other known PAP2s, especially at conserved ..
  46. ncbi Neuroprotective effects of nicergoline in immortalized neurons
    M A Sortino
    Institute of Pharmacology, University of Catania School of Medicine, Italy
    Eur J Pharmacol 368:285-90. 1999
    We studied the potential neuroprotective action of nicergoline in immortalized hypothalamic GT1-7 cells exposed to agents which deplete levels of reduced glutathione, thus causing oxidative stress and cell death...
  47. ncbi Regulation of GNRH production by estrogen and bone morphogenetic proteins in GT1-7 hypothalamic cells
    Hiroyuki Otani
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kitaku, Okayama City 700 8558, Japan
    J Endocrinol 203:87-97. 2009
    ..We here investigated the effects of BMPs on GNRH production controlled by estrogen using murine GT1-7 hypothalamic neuron cells...
  48. ncbi Structure and function of beta -1,4-galactosyltransferase
    Pradman K Qasba
    Structural Glycobiology Section, CCRNP, NCI Frederick, Building 469, Room 221, Frederick, Maryland 21702, USA
    Curr Drug Targets 9:292-309. 2008
    ....
  49. ncbi Depolarizing shift in the GABA-induced current reversal potential by lidocaine hydrochloride
    Yoshihisa Nakahata
    Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    Brain Res 1345:19-27. 2010
    ..Furthermore, LC-HCl caused a depolarizing shift of E(GABA) in cultured GT1-7 cells expressing KCC2 but failed to change E(GABA) in GT1-7 cells without expression of KCC2...
  50. ncbi Inhibitors of the mitogen-activated protein kinase kinase 1/2 signaling pathway clear prion-infected cells from PrPSc
    Elin K Nordström
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Neurosci 25:8451-6. 2005
    ..factor (BDNF), stimulates the formation of PrPSc in a gonadotropin-releasing hormone-secreting neuronal cell line (GT1-1 cells) infected with the Rocky Mountain Laboratory (RML) strain of scrapie as determined by Western blot analysis...
  51. ncbi Expression and signal transduction pathways of endothelin receptors in neuroendocrine cells
    S S Stojilkovic
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Front Neuroendocrinol 17:327-69. 1996
    ..parathyroid glands, pancreas, ovary, uterus, placenta, and prostate, while only ETA receptors are expressed in GT1 neurons, anterior pituitary cells, alpha T3-1 immortalized gonadotropes, parathyroid-derived cells, thyrocytes, ..
  52. ncbi [Effects of nitriles and amides on the growth and the nitrile hydratase activity of the Rhodococcus sp. strain gt1]
    A Iu Maksimov
    Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, ul Pushkina 1 57, Perm, 614081 Russia
    Prikl Biokhim Mikrobiol 39:63-8. 2003
    ..2.1.84) activity of the Rhodococcus sp. strain gt1 isolated from soil were studied...
  53. ncbi Gastro-oesophageal and bile reflux--simultaneous quantitative assessment with gastric and gallbladder emptying evaluation: clinical applicability of a new computerized gammagraphic method
    P M da Costa
    Cirurgia I Propedêutica Cirúrgica, Faculdade de Medicina de Lisboa, Portugal
    Nucl Med Commun 13:817-23. 1992
    ..001). Patients with oesophagitis have a tendency for slower gastric emptying patterns (gastric emptying T1/2, GT1/2 P < 0.05). The calculated specificity for gallbladder emptying parameters was 77...
  54. ncbi Determination of ganglioside composition and structure in human brain hemangioma by chip-based nanoelectrospray ionization tandem mass spectrometry
    Catalin Schiopu
    Mass Spectrometry Laboratory, National Institute for Research and Development in Electrochemistry and Condensed Matter, Str Plautius Andronescu Nr 1, 300224, Timisoara, Romania
    Anal Bioanal Chem 395:2465-77. 2009
    ..In HFC, only GT1 (d18:1/20:0), and GT3 (d18:1/25:1) polysialylated species were detected...
  55. ncbi Effect of Bcl-2 overexpression on mitochondrial structure and function
    Alicia J Kowaltowski
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, 05508 900, Brazil
    J Biol Chem 277:42802-7. 2002
    ..respiration, membrane potential, deltapH, and intramitochondrial [K+] in digitonin-permeabilized PC12 and GT1-7 neural cells that either do not express human Bcl-2 (control transfectants) or that were transfected with and ..
  56. ncbi Astrocyte protection of neurons: role of transforming growth factor-beta signaling via a c-Jun-AP-1 protective pathway
    Krishnan M Dhandapani
    Institute of Molecular Medicine and Genetics, Program in Neurobiology, and Department of Neurology, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 278:43329-39. 2003
    ..The results of the study show that soluble factors in astrocyte-conditioned media (ACM) protect murine GT1-7 neurons from serum deprivation-induced cell death and that this neuroprotection is correlated with enhanced ..
  57. ncbi Synteny conservation of the Z chromosome in 14 avian species (11 families) supports a role for Z dosage in avian sex determination
    I Nanda
    Institute of Human Genetics, University of Wurzburg, Wurzburg, Germany
    Cytogenet Genome Res 122:150-6. 2008
    ..We propose that the accumulation of male-specific genes on the Z chromosome confers selective pressure on the Z to conserve its synteny...
  58. ncbi An evolutionary view of functional diversity in family 1 glycosyltransferases
    Keiko Yonekura-Sakakibara
    RIKEN Plant Science Center, 1 7 22 Suehiro cho, Yokohama 230 0045, Japan
    Plant J 66:182-93. 2011
    ..These enzymes can be classified into at least 92 families, of which family 1 glycosyltransferases (GT1), often referred to as UDP glycosyltransferases (UGTs), is the largest in the plant kingdom...
  59. ncbi Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor
    S Petersenn
    IHF Institute for Hormone and Fertility Research, University of Hamburg, Germany
    Endocrinology 142:2649-59. 2001
    ..was detected in monkey kidney COS-7 cells, human endometrium Skut-1B cells, mouse hypothalamic LHRH neuronal GT1-7 cells, or mouse corticotroph pituitary AtT20 cells...
  60. ncbi Stimulation of luteinizing hormone-releasing hormone (LHRH) gene expression in GT1-7 cells by its metabolite, LHRH-(1-5)
    T J Wu
    Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Endocrinology 146:280-6. 2005
    ..The present study supports the hypothesis that the physiological metabolite of LHRH, LHRH-(1-5), is functionally capable of regulating the reproductive neuroendocrine system...
  61. ncbi Amino-acid substitution in the disordered loop of blood group B-glycosyltransferase enzyme causes weak B phenotype
    Mark H Yazer
    Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Transfusion 45:1178-82. 2005
    ..Another patient has been identified with a 556G>A B(w) allele and the kinetics of the resulting mutant glycosyltransferase were studied...
  62. ncbi Exonic splicing enhancer-dependent splicing of the gonadotropin-releasing hormone premessenger ribonucleic acid is mediated by tra2alpha, a 40-kilodalton serine/arginine-rich protein
    Jae Young Seong
    Hormone Research Center, Chonnam National University, Kwangju 500 757, Korea
    Mol Endocrinol 16:2426-38. 2002
    ..In the presence of an ESE in exon 4 (ESE4), an addition of GT1 NE further increased the excision rate of intron A, whereas the addition of KK1 (a non-GnRH-producing cell) NE ..
  63. ncbi Expression of MAP1a and MAP1b in the ganglionic eminence and the internal capsule of the human fetal brain
    N Ulfig
    Neuroembryonic Research Laboratory, Department of Anatomy, University of Rostock, Gertrudenstr 9, D 18055 Rostock, Germany
    Neurosci Res 38:397-405. 2000
    ..margin of the GE, in a moderate number of cells of the GE and its medial extension, the gangliothalamic body (GTB)...
  64. ncbi Leptin infusion and obesity in mouse cause alterations in the hypothalamic melanocortin system
    Johann Gout
    INSERM U855, Lyon, France
    Obesity (Silver Spring) 16:1763-9. 2008
    ..This hypothesis was reinforced after in vitro studies, using the mouse hypothalamic GT1-7 cell line, since both leptin and Norleucine(4), D-Phenylalanine(7)-alpha-MSH (NDP-alpha-MSH) treatments increased ..
  65. ncbi Complementary DNA cloning for galactosyltransferase associated with tumor and determination of antigenic epitopes recognized by specific monoclonal antibodies
    T Uejima
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    Cancer Res 52:6158-63. 1992
    The galactosyltransferase associated with tumor (GAT) was the name given to the isoenzyme that tends to polymerize resulting in slower moving in a nondenaturing polyacrylamide gel electrophoresis than normal (beta 1-4)..
  66. ncbi Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster
    Akihiko Yamamoto
    Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
    Proc Natl Acad Sci U S A 105:12393-8. 2008
    ..In a screen of 720 lines of D. melanogaster, carrying single P[GT1] transposon insertions, we found 267 lines that showed significant changes in startle-induced locomotor behavior...
  67. ncbi Beta 1-adrenergic and dopamine (D1)-receptors coupled to adenylyl cyclase activation in GT1 gonadotropin-releasing hormone neurosecretory cells
    P R Findell
    Institute of Immunology and Biological Sciences, Syntex Research, Palo Alto, California 94304
    Endocrinology 132:682-8. 1993
    ..dopamine (DA) receptor radioligand (+)-[125I]SCH 23982 were identified on immortalized hypothalamic GnRH neurons (GT1-7 cell lines)...
  68. ncbi Porcine beta1,4-galactosyltransferase-I sequence and expression
    E A Landers
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Reprod Domest Anim 44:228-34. 2009
    Beta1,4-galactosyltransferase-I (B4GALT1), one of seven beta1,4-galactosyltransferases, is an enzyme commonly found in the trans-Golgi complex that adds galactose to oligosaccharides...
  69. ncbi A high-throughput pH indicator assay for screening glycosyltransferase saturation mutagenesis libraries
    Mattias Persson
    Carlsberg Laboratory, Gamle Carlsberg Vej 10, 2500 Valby, Denmark
    Anal Biochem 378:1-7. 2008
    ..screening assay for glycosyltransferases that has been developed using the blood group alpha-(1-->3)-galactosyltransferase (GTB) as a model...
  70. ncbi Gastric GATA-6 DNA-binding protein: proteolysis induced by cAMP
    R Nakagawa
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Suita, Japan
    FEBS Lett 408:301-5. 1997
    The rat gastric GATA DNA-binding protein, GATA-6 (GATA-GT1), was stably expressed in CHO-K1 cells. The GATA-6 protein was localized in the nucleus but not in the cytoplasm...
  71. ncbi Antiprion properties of prion protein-derived cell-penetrating peptides
    Kajsa Löfgren
    Department of Biochemistry and Biophysics, The Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    FASEB J 22:2177-84. 2008
    ..Healthy (GT1-1) and scrapie-infected (ScGT1-1) mouse neuronal hypothalamic cells were treated with various CPPs, including the ..
  72. ncbi Pharmacological analysis of human D1 AND D2 dopamine receptor missense variants
    Munya A Al-Fulaij
    Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA
    J Mol Neurosci 34:211-23. 2008
    ..After expression in either HEK293 or neuronal GT1 cells, basal and ligand-induced signaling of each of these receptors was determined and compared to wild type...
  73. ncbi ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes
    Javier A Alfaro
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
    J Biol Chem 283:10097-108. 2008
    ..glycosyltransferases, an alpha-(1-->3)-N-acetylgalactosaminyltransferase (GTA) and an alpha-(1-->3)-galactosyltransferase (GTB). Of their 354 amino acid residues, GTA and GTB differ by only four "critical" residues...
  74. ncbi Gene expression profile of quinacrine-cured prion-infected mouse neuronal cells
    Carlo Fasano
    Unité de Trafic Membranaire et Pathogénèse, Institut Pasteur, Paris, France
    J Neurochem 105:239-50. 2008
    ..to avoid the complexities of shifting gene expression in a heterogeneous cell population, we used a single clone of GT1 cells that was de novo infected with mouse prion-infected brain homogenate and then treated with quinacrine to ..
  75. ncbi Retinoic acid- and phorbol ester-induced neuronal differentiation down-regulates caveolin expression in GnRH neurons
    Cristina D'Orlando
    Department of Experimental Medicine, University of Milano Bicocca, Monza, Italy
    J Neurochem 104:1577-87. 2008
    GN11 and GT1-7 are immortalized gonadotropin-releasing hormone-positive murine cell lines exhibiting the features of immature olfactory neurons and differentiated hypothalamic neurons, respectively...
  76. ncbi Estrogen regulates KiSS1 gene expression through estrogen receptor alpha and SP protein complexes
    Dali Li
    Institute of Biosciences and Technology, Texas A and M Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Endocrinology 148:4821-8. 2007
    ..gene was up-regulated with the administration of E(2) in estrogen receptor alpha (ERalpha)-positive hypothalamic GT1-7 cells...
  77. ncbi Oral immunization with transgenic rice seeds expressing VP2 protein of infectious bursal disease virus induces protective immune responses in chickens
    Jianxiang Wu
    State Key Laboratory of Rice Biology, Institute of Biotechnology, Zhejiang University, Hangzhou 31009, China
    Plant Biotechnol J 5:570-8. 2007
    ..The VP2 cDNA of IBDV strain ZJ2000 was cloned downstream of the Gt1 promoter of the rice glutelin GluA-2 gene in the binary expression vector, pCambia1301-Gt1...
  78. ncbi Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection
    Julian Schulze zur Wiesch
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Blood 110:1559-69. 2007
    ..Surprisingly, more HCV-specific CD4(+) T-cell responses were detected in patients with chronic non-GT1 infection compared with patients with chronic GT1 infection (P = .017)...
  79. ncbi In vitro evidence of glucose-induced toxicity in GnRH secreting neurons: high glucose concentrations influence GnRH secretion, impair cell viability, and induce apoptosis in the GT1-1 neuronal cell line
    Lubna Pal
    Department of Obstetrics, Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, New York, USA
    Fertil Steril 88:1143-9. 2007
    To evaluate for direct toxic effects of high glucose concentrations on cellular physiology in GnRH secreting immortalized GT1-1 neurons.
  80. ncbi A rapid accurate culture assay for infectivity in Transmissible Encephalopathies
    Ying Liu
    Section of Neuropathology, Yale Medical School, New Haven, CT 06510, USA
    J Neurovirol 14:352-61. 2008
    ..Because we found GT1 hypothalamic cells, unlike neuroblastoma N2a clones, were highly susceptible to a variety of TSE agents, and could ..
  81. ncbi Association of beta-1,3-N-acetylglucosaminyltransferase 1 and beta-1,4-galactosyltransferase 1, trans-Golgi enzymes involved in coupled poly-N-acetyllactosamine synthesis
    Peter L Lee
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Glycobiology 19:655-64. 2009
    ..of UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) and UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 1 (B4GALT1), respectively...
  82. ncbi Cell death mechanisms in GT1-7 GnRH cells exposed to polychlorinated biphenyls PCB74, PCB118, and PCB153
    Sarah M Dickerson
    Division of Pharmacology and Toxicology, University of Texas at Austin, Austin, TX 78712, USA
    Toxicol Appl Pharmacol 237:237-45. 2009
    ..We used an immortalized hypothalamic GT1-7 cell line, which synthesizes the neuroendocrine peptide gonadotropin-releasing hormone (GnRH), to examine the ..
  83. ncbi Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes
    G Hagen
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Germany
    Nucleic Acids Res 20:5519-25. 1992
    Previous analyses of the uteroglobin gene promoter revealed a GT1 box which is also found in the SV40 enhancer...
  84. ncbi Dynamic chromatin modifications control GnRH gene expression during neuronal differentiation and protein kinase C signal transduction
    Anita K Iyer
    Department of Reproductive Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0674, USA
    Mol Endocrinol 25:460-73. 2011
    ..Only in GT1-7 mature GnRH neuronal cells did GnRH regulatory elements display high sensitivity to DNase and enrichment of ..
  85. ncbi Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons
    Tadasuke Komori
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    J Biol Chem 285:37884-94. 2010
    ..reporter assays showed that NREBP repressed GHS-R promoter activity in a hypothalamic neuronal cell line, GT1-7, and its repressive activity was abolished by the replacement of negative regulatory element in GHS-R promoter...
  86. ncbi Glomerular tubular balance is suppressed in adenosine type 1 receptor-deficient mice
    Tracy D Bell
    Dept of Medicine, Georgetown University, 4000 Reservoir Rd, Washington, DC 20057, USA
    Am J Physiol Renal Physiol 299:F1158-63. 2010
    ..A(1)-AR(-/-): 38%; P < 0.001), suggesting reduced glomerular tubular balance (GTB). At higher perfusion rates, J(v) increased modestly in both strains, indicating less GTB at higher flow...
  87. ncbi Differential fibroblast growth factor 8 (FGF8)-mediated autoregulation of its cognate receptors, Fgfr1 and Fgfr3, in neuronal cell lines
    Natasha N Mott
    Department of Cell and Molecular Physiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States of America
    PLoS ONE 5:e10143. 2010
    ..HT-22 cells), and neuroendocrine cells derived from hypothalamic gonadotropin-releasing hormone (GnRH) neurons (GT1-7 cells)...
  88. ncbi Suprachiasmatic nucleus neurons display endogenous resistance to excitotoxicity
    Kathleen Bottum
    Department of Medicine, Division of Internal Medicine and Psychiatry, Southern Illinois School of Medicine, Springfield, IL 62794 9636, USA
    Exp Biol Med (Maywood) 235:237-46. 2010
    ..2 than in the control hypothalamic neurons (GT1-7)...
  89. ncbi Mouse neuronal cells expressing exogenous bovine PRNP and simultaneous downregulation of endogenous mouse PRNP using siRNAs
    Sang Gyun Kang
    Department of Infectious Diseases, College of Veterinary Medicine, KRF Zoonotic Disease Priority Research Institute and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    Prion 4:32-7. 2010
    ..To establish a BSE-specific in vitro cell culture model, N2a and GT1 mouse neuronal cell lines were generated to express the bovine prion protein by transfection of the bovine prion ..
  90. ncbi Expression of beta-1,4-galactosyltransferase-I affects cellular adhesion in human peripheral blood CD4+ T cells
    Yu Han
    Department of Microbiology and Immunology, Medical School of Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, PR China
    Cell Immunol 262:11-7. 2010
    beta-1,4-galactosyltransferase-I (beta-1,4-GalT-I) has two isoforms that differ only in the length of their cytoplasmic domains...
  91. ncbi Binding of an acceptor substrate analog enhances the enzymatic activity of human blood group B galactosyltransferase
    Nora Sindhuwinata
    Institute of Chemistry, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck Germany
    Glycobiology 20:718-23. 2010
    The hydrolysis of the donor substrate uridine diphosphate galactose (UDP-Gal) by human blood group B galactosyltransferase (GTB) has been followed by nuclear magnetic resonance in the presence and in the absence of an acceptor substrate ..
  92. ncbi Pertussis toxin-sensitive signaling of melanocortin-4 receptors in hypothalamic GT1-7 cells defines agouti-related protein as a biased agonist
    Thomas R H Büch
    Walther Straub Institut für Pharmakologie und Toxikologie, Ludwig Maximilians Universitat Munchen, 80336 Munchen
    J Biol Chem 284:26411-20. 2009
    ..Analyzing a hypothalamic cell line (GT1-7 cells), we observed activation of pertussis toxin-sensitive G proteins by the wild-type MC4R as well, reflecting ..
  93. ncbi Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism
    Daiane Beneduzzi
    Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Avenida Doutor Eneas de Carvalho Aguiar 155, 2 andar, Bloco 6, CEP 05403 900 São Paulo, Sao Paulo, Brazil
    Eur J Endocrinol 165:145-50. 2011
    ..In humans, necdin plays a potential role in the hypogonadotropic hypogonadism phenotype in patients with Prader-Willi syndrome...
  94. ncbi Enterostatin alters protein trafficking to inhibit insulin secretion in Beta-TC6 cells
    Miejung Park
    Center for Advanced Nutrition, Utah State University, 4715 Old Main Hill, Logan, UT 84322 4715, USA
    Peptides 30:1866-73. 2009
    ..of the genomic response of both a human hepatoma cell line (HepG2 cells) and a mouse hypothalamic cell line (GT1-7 cells) to enterostatin suggested that it might regulate protein trafficking...
  95. ncbi Intracellular oxidative stress and cytotoxicity in rat primary cortical neurons exposed to cholesterol secoaldehyde
    Achuthan C Raghavamenon
    Department of Environmental Toxicology, Southern University and A and M College, Baton Rouge, LA 70813, USA
    Biochem Biophys Res Commun 386:170-4. 2009
    ..ChSeco or 3beta-hydroxy-5-oxo-5,6-secocholestan-6-al) has been shown to induce Abeta aggregation and apoptosis in GT1-7 hypothalamic neurons...
  96. ncbi Underlying mechanism of actions of tefluthrin, a pyrethroid insecticide, on voltage-gated ion currents and on action currents in pituitary tumor (GH3) cells and GnRH-secreting (GT1-7) neurons
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan
    Toxicology 258:70-7. 2009
    ..Its effects on membrane ion currents in pituitary tumor (GH3) cells and in hypothalamic (GT1-7) neurons were investigated...
  97. ncbi Estrogen modulates potassium currents and expression of the Kv4.2 subunit in GT1-7 cells
    Imre Farkas
    Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, 1083 Budapest, Hungary
    Neurochem Int 50:619-27. 2007
    ..known modulators of firing rate, was therefore examined in our experiments using immortalized GnRH-producing GT1-7 neurons...
  98. ncbi Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line
    Wiweka Kaszubska
    Metabolic Disease Research, Global Pharmaceutical Products Division, Department 47R, Bldg AP10, 100 Abbott Park Road, Abott Park, IL 60064 6099, USA
    Mol Cell Endocrinol 195:109-18. 2002
    ..A mouse hypothalamic cell line, GT1-7, was established as a suitable cell model for the study of leptin signaling...
  99. ncbi Oligosaccharide preferences of beta1,4-galactosyltransferase-I: crystal structures of Met340His mutant of human beta1,4-galactosyltransferase-I with a pentasaccharide and trisaccharides of the N-glycan moiety
    Velavan Ramasamy
    Laboratory of Experimental and Computational Biology, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Mol Biol 353:53-67. 2005
    beta-1,4-Galactosyltransferase-I (beta4Gal-T1) transfers galactose from UDP-galactose to N-acetylglucosamine (GlcNAc) residues of the branched N-linked oligosaccharide chains of glycoproteins...
  100. ncbi Estrogen directly respresses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha)- and ERbeta-expressing GT1-7 GnRH neurons
    D Roy
    Institute for Medical Sciences, University of Toronto, Ontario, Canada
    Endocrinology 140:5045-53. 1999
    ..of GnRH messenger RNA (mRNA) levels using the well characterized, GnRH-secreting, hypothalamic cell line, GT1-7. Using RT-PCR, we first investigated estrogen receptor transcript expression in GT1-7 neurons...
  101. ncbi cAMP modulates the excitability of immortalized H=hypothalamic (GT1) neurons via a cyclic nucleotide gated channel
    A Charles
    Department of Neurology, University of California Los Angeles, School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Mol Endocrinol 15:997-1009. 2001
    b>GT1 cells are immortalized hypothalamic neurons that show spontaneous bursts of action potentials and oscillations in intracellular calcium concentration [Ca(2+)](i), as well as pulsatile release of GNRH: We investigated the role of ..

Research Grants73

  1. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    Pamela L Mellon; Fiscal Year: 2010
    ..We will utilize two major model systems: our immortalized GnRH-secreting hypothalamic cells (GT1) and genetically manipu- lated mice...
  2. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    PAMELA MELLON; Fiscal Year: 2007
    ..We will utilize two major model systems: our immortalized GnRH-secreting hypothalamic cells (GT1) and genetically manipulated mice...
  3. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    PAMELA MELLON; Fiscal Year: 1993
    ..We plan a systematic analysis of the responses to known modulatory agents in the GnRH neuronal cen line, GT1. Our second goal is to unravel the genetic control mechanisms which specify GnRH expression to an exclusive ..
  4. Circadian Regulation of Gonadotropin-Releasing Hormone
    Patrick E Chappell; Fiscal Year: 2010
    ..Studies in the previous funding period, using GnRH-secreting GT1-7 cell lines and transgenic mouse models, demonstrated that perturbations in GnRH-specific clocks can modulate ..
  5. AUTOREGULATION OF GLOMERULAR FILTRATION RATE
    Roland Blantz; Fiscal Year: 2000
    ..This coordination is largely mediated by the processes of glomerular tubular balance (GTB) which is the flow dependence of tubular reabsorption, and tubuloglomerular feedback (TGF), which is the negative ..
  6. B-Synuclein as a Treatment for Lewy Body Disease
    Eliezer Masliah; Fiscal Year: 2005
    ..To test this hypothesis, alpha-synuclein- overexpressing GT1-7 and B103 neuronal cells will be co- transfected with beta-synuclein GT1-7 cells will be evaluated for cell ..
  7. AUTOREGULATION OF GLOMERULAR FILTRATION RATE
    Roland Blantz; Fiscal Year: 2004
    ..This coordination is mediated by the combined processes of glomerulo-tubular balance (GTB), the flow dependence of tubular reabsorption, and tubuloglomerular feedback (TGF),the negative feedback regulation ..
  8. MOLECULAR MECHANISM OF PHOTORECEPTOR G PROTEIN SIGNALING
    Nikolai O Artemyev; Fiscal Year: 2010
    ..The properties and regulation of rod transducin Gt1 during phototransduction are understood to a far greater extent than those of cone transducin Gt2...
  9. AUTOREGULATION OF GLOMERULAR FILTRATION RATE
    Roland Blantz; Fiscal Year: 2009
    ..This is achieved through the coordinated actions of glomerulotubular balance (GTB) and the tubuloglomerular feedback (TGF) system...
  10. AUTOREGULATION OF GLOMERULAR FILTRATION RATE
    Roland Blantz; Fiscal Year: 2007
    ..This is achieved through the coordinated actions of glomerulotubular balance (GTB) and the tubuloglomerular feedback (TGF) system...
  11. AUTOREGULATION OF GLOMERULAR FILTRATION RATE
    Roland Blantz; Fiscal Year: 2009
    ..This is achieved through the coordinated actions of glomerulotubular balance (GTB) and the tubuloglomerular feedback (TGF) system...
  12. AUTOREGULATION OF GLOMERULAR FILTRATION RATE
    Roland C Blantz; Fiscal Year: 2010
    ..This is achieved through the coordinated actions of glomerulotubular balance (GTB) and the tubuloglomerular feedback (TGF) system...
  13. CELLULAR PROTEIN MATURATION AND DEGRADATION
    Daniel N Hebert; Fiscal Year: 2010
    ..The UDP-glucose: glycoprotein glucosyltransferase (GT1) is currently the only known protein that can modify the glycan structure dependent upon the properties of the ..
  14. Functional Characterization of Leishmania Transporters
    Scott M Landfear; Fiscal Year: 2010
    ..The second aim will investigate the specific functions of the 3 glucose transporter isoforms GT1, GT2, and GT3...
  15. CELLULAR PROTEIN MATURATION AND DEGRADATION
    Daniel Hebert; Fiscal Year: 2009
    ..The UDP-glucose: glycoprotein glucosyltransferase (GT1) is currently the only known protein that can modify the glycan structure dependent upon the properties of the ..
  16. Axial Flow Effects in Proximal Tubule
    TONG WANG WANG; Fiscal Year: 2010
    ..These studies will provide new information on mechanisms of glomerulotubular balance (GTB) and aspects of renal fluid and HCO3- transport in physiological and pathophysiological conditions...
  17. Axial Flow Effects in Proximal Tubule
    Tong Wang; Fiscal Year: 2009
    ..These studies will provide new information on mechanisms of glomerulotubular balance (GTB) and aspects of renal fluid and HCO3- transport in physiological and pathophysiological conditions...
  18. Functional Characterization of Leishmania Transporters
    Scott Landfear; Fiscal Year: 2007
    ..The second aim will investigate the specific functions of the 3 glucose transporter isoforms GT1, GT2, and GT3...
  19. ADENOSINE RECEPTORS IN THE KIDNEY
    William J Welch; Fiscal Year: 2010
    ..A1-ARs mediate an important intrarenal regulatory system in the proximal tubule (PT), glomerulotubular balance (GTB)...
  20. ADENOSINE RECEPTORS IN THE KIDNEY
    William Welch; Fiscal Year: 2007
    ..A1-ARs mediate an important intrarenal regulatory system in the proximal tubule (PT), glomerulotubular balance (GTB)...
  21. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    PAMELA MELLON; Fiscal Year: 2005
    ..We will utilize two model systems: our immortalized GnRH-secreting hypothalamic cell line (GT1) and genetically manipulated mice...
  22. ONTOGENY AND EXPRESSION OF THE CFTR IN BRAIN
    ANDREW MULBERG; Fiscal Year: 2003
    ..Control mechanisms of neurosecretion will be examined in the fetal brain, and GT1-7, a GnRH-expressing hypothalamic neuronal cell line...
  23. Multiple circadian oscillators: Regulation of a neuroendocrine rhythm
    Sandra J Legan; Fiscal Year: 2010
    ..Furthermore, immortalized GnRH neurons, GT1-7 cells, exhibit circadian rhythms of clock gene expression in vitro...
  24. Multiple circadian oscillators: Regulation of a neuroendocrine rhythm
    MARILYN DUNCAN; Fiscal Year: 2009
    ..Furthermore, immortalized GnRH neurons, GT1-7 cells, exhibit circadian rhythms of clock gene expression in vitro...
  25. Multiple circadian oscillators: Regulation of a neuroendocrine rhythm
    MARILYN J contact DUNCAN; Fiscal Year: 2011
    ..Furthermore, immortalized GnRH neurons, GT1-7 cells, exhibit circadian rhythms of clock gene expression in vitro...