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Genomes and Genes
| fibulin 2SummaryGene Symbol: fibulin 2 Description: fibulin 2 Alias: FIBL-2, fibulin-2 Species: human Top Publications
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Publications
Expression of ECM proteins fibulin-1 and -2 in acute and chronic liver disease and in cultured rat liver cellsFabio Piscaglia
Department of Internal Medicine and Gastroenterology, University of Gottingen, Gottingen, Germany
Cell Tissue Res 337:449-62. 2009..Thus, fibulin-1 and -2 respond differentially to single and repeated damaging noxae, and their expression is differently present in liver cells. Expression of the fibulin-2 gene is regulated by TGF-beta1 in liver myofibroblasts...- Association of extracellular matrix proteins fibulin-1 and fibulin-2 with fibronectin in bone marrow stromaY C Gu
Department of Cell and Molecular Biology, Lund University, Lund, Sweden
Br J Haematol 109:305-13. 2000.... - Binding of mouse and human fibulin-2 to extracellular matrix ligandsT Sasaki
Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
J Mol Biol 254:892-9. 1995..This indicated multifunctional binding properties for fibulin-2 and several alternative routes for its integration into basement membranes and other extracellular structures... - The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryoN Miosge
Abt Histologie, Universitat Gottingen, Germany
Histochem J 28:109-16. 1996..The early embryonic expression of both fibulins indicates specific roles during organ development and, in particular, involvements in the differentiation of heart, skeletal and neuronal structures... - Fibrillin-1 and fibulin-2 interact and are colocalized in some tissuesD P Reinhardt
Shriners Hospital for Crippled Children, Portland, Oregon 97201, USA
J Biol Chem 271:19489-96. 1996.... - Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium bindingT C Pan
Department of Biochemistry and Molecular Biology, Jefferson Institute of Molecular Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5541
J Cell Biol 123:1269-77. 1993..The latter studies also demonstrated an extracellular localization for fibulin-2 in basement membranes and other connective tissue compartments... - Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequencesA Utani
Laboratory of Developmental Biology, NIDR, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 272:2814-20. 1997..Together these results suggest that fibulin-2 functions to bridge laminin-1 and laminin-5 with other extracellular matrix proteins, providing a linkage between the cell surface and the basement membrane... - Identification of gene signatures for invasive colorectal tumor cellsAnja H Wiese
Institut für allgemeine Pathologie und pathologische Anatomie, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
Cancer Detect Prev 31:282-95. 2007..Gene signatures of sporadic colorectal carcinoma tissues and microdissected colorectal tumor cells were analyzed to identify stromal and tumor cell-specific markers, respectively... - Mouse embryo fibroblasts lacking the tumor suppressor menin show altered expression of extracellular matrix protein genesYoungmi Ji
Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA
Mol Cancer Res 5:1041-51. 2007..Specifically, transcripts for fibulin 2 (Fbln2), periostin (Postn), and versican [chondroitin sulfate proteoglycan (Cspg2)], genes critical for the .. - Fibulin-2 is dispensable for mouse development and elastic fiber formationFrancois Xavier Sicot
Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
Mol Cell Biol 28:1061-7. 2008..The results demonstrate that fibulin-2 is not required for mouse development and elastic fiber formation and suggest possible functional redundancy between fibulin-1 and fibulin-2... - Ciz, a transcription factor with a nucleocytoplasmic shuttling activity, interacts with C-propeptides of type I collagenTadayoshi Hayata
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3 10 Kanda Surugadai 2 Chome, Chiyoda ku, Tokyo 101 0062, Japan
Biochem Biophys Res Commun 368:205-10. 2008..In terms of intracellular localization, overexpressed C-propeptides of Col1 and Ciz were co-localized in nuclei. These results revealed that Ciz interacts with C-propeptides of type I collagen and this association takes place in nuclei... - Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in IndiaIndranil Chattopadhyay
Institute of Pathology, New Delhi 110029, India
Mutat Res 696:130-8. 2010..These unique copy number alteration profiles should be taken into consideration when developing biomarkers for the early detection of ESCC in high-risk areas of India in association with tobacco and betel quid use... - Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sitesRobert N Ono
Shriners Hospital for Children, Oregon Health and Science University, Portland, Oregon 97239, USA
J Biol Chem 284:16872-81. 2009..These studies also suggest that the fibulins may affect matrix sequestration of LTBPs, because in vitro interactions between these proteins are competitive... - Epigenetic analysis of childhood acute lymphoblastic leukemiaThomas L Dunwell
Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK
Epigenetics 4:185-93. 2009..Whilst FBLN2 (fibulin 2) and THRB (thyroid hormone receptor, beta) showed frequent methylation in B-ALL (58%; 56% respectively), but .. - Pathway analysis of differentially expressed genes in patients with acute aortic dissectionSalah A Mohamed
Department of Cardiac Surgery, University Clinic of Schleswig Holstein, Campus Luebeck, Luebeck, Germany
Biomark Insights 4:81-90. 2009..This study was conducted to gain a better understanding of the molecular mechanisms underlying AAD and to support the future development of a clinical test for monitoring patients at high risk... - New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiationGerrit J Bouma
The Jackson Laboratory, Bar Harbor, Maine, USA
Biol Reprod 82:380-9. 2010.... - Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injuryShelby L Chapman
Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9148
Arterioscler Thromb Vasc Biol 30:68-74. 2010..Here, we generated double knockout mice for Fbln5 and Fbln2 (termed DKO) and examined the role of fibulins-2 and -5 in development and injury response of the blood vessel wall... - Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) geneDessislava Markova
Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Am J Hum Genet 72:998-1004. 2003..The results demonstrate that a heterozygous mutation in fibulin-5 can cause cutis laxa and also suggest that fibulin-5 and elastin gene mutations are not the exclusive cause of the disease... - The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchorEva Bengtsson
Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, SE 221 84 Lund, Sweden
J Biol Chem 277:15061-8. 2002..Based on the location of PRELP and its interaction with perlecan heparan sulfate chains and collagen, we propose a function of PRELP as a molecule anchoring basement membranes to the underlying connective tissue... - Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteinsT Sasaki
Max Planck Institut fur Biochemie, Martinsried, D 82152, Germany
J Mol Biol 314:751-63. 2001..Immunological studies showed a similar partial processing in cell culture and tissues and the persistence of the released fragment in tissues. This indicated that both N-terminal regions of the gamma2 chain may have a function in vivo... - Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomesR Z Zhang
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
Genomics 22:425-30. 1994..The expression pattern differs from that of fibulin-1. The fibulin-2 gene was localized by in situ hybridization to the p24-p25 region of human chromosome 3 and to the band D-E of mouse chromosome 6... - Fibulin-2: genetic mapping and exclusion as a candidate gene in Marfan syndrome type 2G Collod
INSERM U383, Hopital Necker Enfants Malades, Universite Rene Descartes, Paris, France
Eur J Hum Genet 4:292-5. 1996..Furthermore, two-point lod scores were generated between these markers and anonymous markers arrayed on the genetic map of 3p and closely linked to MFS2. These analyses placed FBLN2 at marker D3S1585... - Dimer model for the microfibrillar protein fibulin-2 and identification of the connecting disulfide bridgeT Sasaki
Max Planck Institut fur Biochemie, Martinsried, Germany
EMBO J 16:3035-43. 1997..This was demonstrated by surface plasmon resonance assay which showed a distinct interaction between domains N and II with a Kd of approximately 0.7 microM... - The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycansJ C Brown
Max Planck Institut fur Biochemie, Martinsried, Germany
Eur J Biochem 250:39-46. 1997..05-0.2 microM and about 2 microM). Perlecan domain V therefore seems to participate in the supramolecular assembly and cell connections of basement membranes... - Confocal laser scanning analysis of the association of fibulin-2 with fibrillin-1 and fibronectin define different stages of skin regenerationM Raghunath
Department of Dermatology, University of Munster, Germany
J Invest Dermatol 112:97-101. 1999..This suggests interaction of fibulin-2 with both fibronectin fibrils and fibrillin microfibrils, and is consistent with in vitro binding data... - Fibulin-2 exhibits high degree of variability, but no structural changes concordant with abdominal aortic aneurysmsH Kuivaniemi
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI
Eur J Hum Genet 6:642-6. 1998..There was an excellent overall agreement between direct sequencing of PCR-products and conformation sensitive gel electrophoresis... - Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteinsT Sasaki
Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152, Martinsried, Germany
FEBS Lett 460:280-4. 1999..The colocalization of these proteins emphasizes the potential for in vivo interactions... - Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissuesJ F Talts
Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
J Biol Chem 275:35192-9. 2000..Immunogold staining demonstrated an association of the alpha4 chain primarily with microfibrillar regions rather than with basement membranes, while laminin alpha2 chains appear primarily associated with various basement membranes... - The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain bindingA I Olin
Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, BMC Plan C12, SE 221 84 Lund, Sweden
J Biol Chem 276:1253-61. 2001..Electron microscopy confirmed the mapping and demonstrated that hyaluronan-aggrecan complexes can be cross-linked by the fibulins... - Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecanM Hopf
Max Planck Institut fur Biochemie, Martinsried, D 82152, Germany
J Mol Biol 311:529-41. 2001..This implicates a complex cluster of heterotypic interaction sites apparently important for the supramolecular organization of perlecan in tissues... - Increased deposition of fibulin-2 in solar elastosis and its colocalization with elastic fibresN Hunzelmann
Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50924 Cologne, Germany
Br J Dermatol 145:217-22. 2001..Fibulin-2 is a 195-kDa protein belonging to a novel family of extracellular matrix proteins that might be involved in microfibril and elastic fibre organization... - Identification of 5 novel genes methylated in breast and other epithelial cancersVictoria K Hill
Department of Medical and Molecular Genetics, University of Birmingham, UK
Mol Cancer 9:51. 2010..We utilized one such recently developed approach, MIRA (methylated-CpG island recovery assay) combined with CpG island arrays to identify novel genes that are epigenetically inactivated in breast cancer...
Research Grants
- Somatic support cell function in gonad developmentGERRIT BOUMA; Fiscal Year: 2006..The proposed experiments will identify genes expressed in gonadal SSCs that play a role in gonadal XY sex reversal. ..
- The Role of Fibulin-5 in Cardiovascular RemodelingHiromi Yanagisawa; Fiscal Year: 2007..abstract_text> ..
- Protease regulation and integrity of connective tissues of the pelvic floorHIROMI contact YANAGISAWA; Fiscal Year: 2010....
- Loss of Matrix Regulation and Aortic Aneurysm Development in vivoHiromi Yanagisawa; Fiscal Year: 2011..We will study how this protein functions to prevent the development of aortic aneurysms. ..